                         SEQUENCE LISTING

<110>  ADAMED SP. Z O.O.
       Pieczykolan, Jerzy  Szczepan
       Pawlak, Sebastian  Dominik
       erek, Bartomiej  Maciej
       Rzga, Piotr  Kamil
       Szawowska, Urszula  Marta
 
<120>  Anticancer fusion protein

<130>  KP1

<150>  PL394618
<151>  2011-04-19

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  1

Leu Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile 
1               5                   10                  15      


Ile Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro 
            20                  25                  30          


Gly Arg Val Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
        35                  40                  45              


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
    50                  55                  60                  


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
65                  70                  75                  80  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
                85                  90                  95      


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
            100                 105                 110         


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
        115                 120                 125             


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
    130                 135                 140                 


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
145                 150                 155                 160 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
                165                 170                 175     


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
            180                 185                 190         


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
        195                 200             


<210>  2
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  2

Glu Met Thr Pro Val Asn Pro Gly Arg Val Val Arg Glu Arg Gly Pro 
1               5                   10                  15      


Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
            20                  25                  30          


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
        35                  40                  45              


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
    50                  55                  60                  


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
65                  70                  75                  80  


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
                85                  90                  95      


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
            100                 105                 110         


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
        115                 120                 125             


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
    130                 135                 140                 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
145                 150                 155                 160 


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
                165                 170                 175     


Val Gly 
        


<210>  3
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  3

Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
1               5                   10                  15      


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            20                  25                  30          


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        35                  40                  45              


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    50                  55                  60                  


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
65                  70                  75                  80  


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                85                  90                  95      


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            100                 105                 110         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        115                 120                 125             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    130                 135                 140                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
145                 150                 155                 160 


Gly Pro Leu Gly Leu Ala Gly Arg Val Val Arg Glu Met Thr Pro Val 
                165                 170                 175     


Asn Pro Gly 
            


<210>  4
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  4

Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
1               5                   10                  15      


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            20                  25                  30          


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        35                  40                  45              


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    50                  55                  60                  


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
65                  70                  75                  80  


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                85                  90                  95      


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            100                 105                 110         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        115                 120                 125             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    130                 135                 140                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
145                 150                 155                 160 


Gly Pro Leu Gly Leu Ala Gly Arg Val Val Arg Leu Ser Glu Asp Lys 
                165                 170                 175     


Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile Ile Gly His Leu 
            180                 185                 190         


Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
        195                 200                 


<210>  5
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  5

Leu Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile 
1               5                   10                  15      


Ile Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro 
            20                  25                  30          


Gly Arg Val Val Arg Pro Leu Gly Leu Ala Gly Thr Ser Glu Glu Thr 
        35                  40                  45              


Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg 
    50                  55                  60                  


Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
65                  70                  75                  80  


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
                85                  90                  95      


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
            100                 105                 110         


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
        115                 120                 125             


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
    130                 135                 140                 


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
145                 150                 155                 160 


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
                165                 170                 175     


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
            180                 185                 190         


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
        195                 200                 205             


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
    210                 215                 220                 


Gly Ala Phe Leu Val Gly 
225                 230 


<210>  6
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  6

Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
1               5                   10                  15      


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Cys Ala Ala Cys Ala 
            180                 185                 190         


Ala Ala Cys Pro Leu Gly Leu Ala Gly Arg Val Val Arg Leu Ser Glu 
        195                 200                 205             


Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile Ile Gly 
    210                 215                 220                 


His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
225                 230                 235             


<210>  7
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  7

Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
1               5                   10                  15      


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Cys Ala Ala Cys Ala 
            180                 185                 190         


Ala Ala Cys Pro Leu Gly Leu Ala Gly Arg Val Val Arg Glu Met Thr 
        195                 200                 205             


Pro Val Asn Pro Gly 
    210             


<210>  8
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  8

Lys Arg Arg Gln Thr Ser Ala Thr Asp Phe Tyr His Ser Lys Arg Arg 
1               5                   10                  15      


Leu Ile Phe Ser Lys Pro Arg Arg Pro Tyr Arg Val Val Arg Pro Leu 
            20                  25                  30          


Gly Leu Ala Gly Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Leu Val Gly 
        195         


<210>  9
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  9

Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
1               5                   10                  15      


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Cys Ala Ala Cys Ala 
            180                 185                 190         


Ala Ala Cys Pro Leu Gly Leu Ala Gly Arg Val Val Arg Lys Arg Arg 
        195                 200                 205             


Gln Thr Ser Ala Thr Asp Phe Tyr His Ser Lys Arg Arg Leu Ile Phe 
    210                 215                 220                 


Ser Lys Pro Arg Arg Pro Tyr 
225                 230     


<210>  10
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  10

Met Trp Tyr Arg Pro Asp Leu Asp Glu Arg Lys Gln Gln Lys Arg Glu 
1               5                   10                  15      


Arg Val Val Arg Pro Leu Gly Leu Ala Gly Gly Gly Cys Ala Ala Ala 
            20                  25                  30          


Cys Ala Ala Cys Gly Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr 
        35                  40                  45              


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
    50                  55                  60                  


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
65                  70                  75                  80  


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
                85                  90                  95      


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
            100                 105                 110         


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
        115                 120                 125             


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
    130                 135                 140                 


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
145                 150                 155                 160 


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
                165                 170                 175     


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
            180                 185                 190         


Phe Phe Gly Ala Phe Leu Val Gly 
        195                 200 


<210>  11
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  11

Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
1               5                   10                  15      


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Cys Ala Ala Cys Ala 
            180                 185                 190         


Ala Ala Cys Gly Gly Gly Pro Leu Gly Leu Ala Gly Arg Val Val Arg 
        195                 200                 205             


Arg Arg Arg Arg Arg Arg Arg Gly Gly Gly Phe Gln Leu Arg Gln Pro 
    210                 215                 220                 


Pro Leu Val Pro Ser Arg Lys Gly Glu 
225                 230             


<210>  12
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  12

Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
1               5                   10                  15      


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            20                  25                  30          


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        35                  40                  45              


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    50                  55                  60                  


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
65                  70                  75                  80  


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                85                  90                  95      


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            100                 105                 110         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        115                 120                 125             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    130                 135                 140                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Pro Leu Gly Leu Ala Gly Arg Val Val Arg Gly 
                165                 170                 175     


Gly Gly Ser Gly Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His 
            180                 185                 190         


Val Tyr Ser Glu Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro 
        195                 200                 205             


Gly Arg Glu Ile Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu 
    210                 215                 220                 


Phe Ser Ala Ile Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln 
225                 230                 235                 240 


Phe Val Ala Glu Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile 
                245                 250                 255     


Asp Leu Val Ala Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp 
            260                 265                 270         


Lys Leu Ile Glu Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu 
        275                 280                 285             


Glu His Lys Val Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser 
    290                 295                 300                 


Arg Glu Leu Val Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu 
305                 310                 315                 320 


Gly Ile Glu Ala Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu 
                325                 330                 335     


Tyr Phe Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile 
            340                 345                 350         


His Tyr Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg 
        355                 360                 365             


Phe Val Phe Ser Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr 
    370                 375                 380                 


Asp Pro Ser Leu Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr 
385                 390                 395                 400 


Asn Asn Asp Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln 
                405                 410                 415     


Thr Val Thr Leu Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu 
            420                 425                 430         


Phe Lys Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met 
        435                 440                 445             


His Leu Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr 
    450                 455                 460                 


Ser Pro Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val 
465                 470                 475                 480 


Asn Gly Gly Ala Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu 
                485                 490                 495     


Gly Leu Leu Gln Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile 
            500                 505                 510         


Ala Gly Glu Gly Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe 
        515                 520                 525             


Asp Gly Thr Asn Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr 
    530                 535                 540                 


Ser Arg Asn Glu Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys 
545                 550                 555                 560 


Val Leu Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala 
                565                 570                 575     


Arg Cys Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
            580                 585                 590 


<210>  13
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  13

Phe Leu Asp Thr Leu Val Val Leu His Arg Lys Pro Arg Arg Pro Tyr 
1               5                   10                  15      


Arg Val Val Arg Pro Leu Gly Leu Ala Gly Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185         


<210>  14
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  14

Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
1               5                   10                  15      


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            20                  25                  30          


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        35                  40                  45              


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    50                  55                  60                  


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
65                  70                  75                  80  


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                85                  90                  95      


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            100                 105                 110         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        115                 120                 125             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    130                 135                 140                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
145                 150                 155                 160 


Gly Gly Ser Pro Leu Gly Leu Ala Gly Arg Val Val Arg Asp Arg Gln 
                165                 170                 175     


Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Gly Met 
            180                 185                 190         


Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn 
        195                 200             


<210>  15
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  15

Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
1               5                   10                  15      


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            20                  25                  30          


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        35                  40                  45              


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    50                  55                  60                  


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
65                  70                  75                  80  


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                85                  90                  95      


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            100                 105                 110         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        115                 120                 125             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    130                 135                 140                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
145                 150                 155                 160 


Gly Gly Ser Pro Leu Gly Leu Ala Gly Arg Val Val Arg Asp Arg Gln 
                165                 170                 175     


Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Ala Val 
            180                 185                 190         


Thr Asp His Pro Asp Arg Leu Trp Ala Trp Glu Lys Phe 
        195                 200                 205 


<210>  16
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  16

Phe Trp Leu Arg Phe Thr Lys Pro Arg Arg Pro Tyr Arg Val Val Arg 
1               5                   10                  15      


Pro Leu Gly Leu Ala Gly Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            20                  25                  30          


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        35                  40                  45              


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    50                  55                  60                  


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
65                  70                  75                  80  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                85                  90                  95      


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            100                 105                 110         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        115                 120                 125             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    130                 135                 140                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
145                 150                 155                 160 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                165                 170                 175     


Phe Gly Ala Phe Leu Val Gly 
            180             


<210>  17
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  17

Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Val Val Arg Pro Leu Gly Leu Ala Gly Arg Val Ala 
            20                  25                  30          


Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
        35                  40                  45              


Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
    50                  55                  60                  


Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
65                  70                  75                  80  


Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
                85                  90                  95      


Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
            100                 105                 110         


Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
        115                 120                 125             


Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
    130                 135                 140                 


Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
145                 150                 155                 160 


Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
                165                 170                 175     


Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185                 190 


<210>  18
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  18

Trp Cys Pro Thr Gly Phe Lys Val Gly Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Val Val Arg Pro Leu Gly Leu Ala Gly Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185         


<210>  19
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  19

Gly Ile Gly Ala Arg Leu Lys Val Leu Thr Thr Gly Leu Pro Arg Ile 
1               5                   10                  15      


Ser Trp Ile Lys Arg Lys Arg Gln Gln Arg Val Val Arg Pro Leu Gly 
            20                  25                  30          


Leu Ala Gly Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
        35                  40                  45              


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
    50                  55                  60                  


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
65                  70                  75                  80  


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
                85                  90                  95      


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
            100                 105                 110         


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
        115                 120                 125             


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
    130                 135                 140                 


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
145                 150                 155                 160 


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
                165                 170                 175     


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
            180                 185                 190         


Phe Leu Val Gly 
        195     


<210>  20
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  20

Ala Leu Tyr Leu Ala Ile Arg Arg Arg Arg Arg Arg Arg Arg Val Val 
1               5                   10                  15      


Arg Pro Leu Gly Leu Ala Gly Arg Val Ala Ala His Ile Thr Gly Thr 
            20                  25                  30          


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
        35                  40                  45              


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
    50                  55                  60                  


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
65                  70                  75                  80  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
                85                  90                  95      


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
            100                 105                 110         


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
        115                 120                 125             


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
    130                 135                 140                 


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
145                 150                 155                 160 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
                165                 170                 175     


Phe Phe Gly Ala Phe Leu Val Gly 
            180                 


<210>  21
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  21

Ala Pro Ser Gly His Tyr Lys Gly Arg Val Val Arg Pro Leu Gly Leu 
1               5                   10                  15      


Ala Gly Ala Pro Ser Gly His Tyr Lys Gly Gly Gly Arg Val Ala Ala 
            20                  25                  30          


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
        35                  40                  45              


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
    50                  55                  60                  


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
65                  70                  75                  80  


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
                85                  90                  95      


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
            100                 105                 110         


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
        115                 120                 125             


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
    130                 135                 140                 


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
145                 150                 155                 160 


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
                165                 170                 175     


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185                 


<210>  22
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  22

Val Asn Trp Lys Lys Val Leu Gly Lys Ile Ile Lys Val Ala Lys Arg 
1               5                   10                  15      


Val Val Arg Pro Leu Gly Leu Ala Gly Pro Gln Arg Val Ala Ala His 
            20                  25                  30          


Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser 
        35                  40                  45              


Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser 
    50                  55                  60                  


Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu 
65                  70                  75                  80  


Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr 
                85                  90                  95      


Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln 
            100                 105                 110         


Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu 
        115                 120                 125             


Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr 
    130                 135                 140                 


Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn 
145                 150                 155                 160 


Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp 
                165                 170                 175     


His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185             


<210>  23
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  23

Lys Trp Val Val Ser His Ala Arg Leu Met Tyr Ser Phe Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Val Val Arg Pro Leu Gly Leu Ala Gly Cys 
            20                  25                  30          


Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            180                 185                 190         


Gly 
    


<210>  24
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  24

Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
1               5                   10                  15      


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Cys Ala Ala Cys Ala 
            180                 185                 190         


Ala Ala Cys Pro Leu Gly Leu Ala Gly Arg Val Val Arg Asp Ala Ala 
        195                 200                 205             


Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg Ala Gly Ala 
    210                 215                 220                 


Arg Val Val Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys 
225                 230                 235                 240 


Trp Lys Lys 
            


<210>  25
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  25

Met Trp Lys Trp Phe His Asn Val Leu Ser Trp Trp Trp Leu Leu Ala 
1               5                   10                  15      


Asp Lys Arg Pro Ala Arg Asp Tyr Asn Arg Lys Arg Val Val Arg Pro 
            20                  25                  30          


Leu Gly Leu Ala Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
        35                  40                  45              


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    50                  55                  60                  


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
65                  70                  75                  80  


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                85                  90                  95      


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            100                 105                 110         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        115                 120                 125             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    130                 135                 140                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
145                 150                 155                 160 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                165                 170                 175     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            180                 185                 190         


Phe Gly Ala Phe Leu Val Gly 
        195                 


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<300>
<301>  Kono K, Ueba T, Takahashi JA, Murai N, Hashimoto N, Myoumoto A, 
       Itoh N,Fukumoto M
<302>  In vitro growth suppression of human glioma cells by a 16-mer 
       oligopeptide: a potential new treatment modality for malignant 
       glioma.
<303>  . J Neurooncol
<304>  63
<305>  2
<306>  163-71
<307>  2003-07-30

<400>  26

Met Trp Tyr Arg Pro Asp Leu Asp Glu Arg Lys Gln Gln Lys Arg Glu 
1               5                   10                  15      


<210>  27
<211>  34
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/AAB58754.1
<309>  2008-10-16
<313>  (464)..(496)

<400>  27

Leu Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile 
1               5                   10                  15      


Ile Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro 
            20                  25                  30          


Gly Arg 
        


<210>  28
<211>  8
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/ AAB58754.1
<309>  2008-10-16
<313>  (489)..(496)

<400>  28

Glu Met Thr Pro Val Asn Pro Gly 
1               5               


<210>  29
<211>  20
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/ BAG70236.1
<309>  2008-08-02
<313>  (141)..(160)

<400>  29

Lys Arg Arg Gln Thr Ser Ala Thr Asp Phe Tyr His Ser Lys Arg Arg 
1               5                   10                  15      


Leu Ile Phe Ser 
            20  


<210>  30
<211>  18
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI/
<309>  2010-03-04
<313>  (417)..(431)

<400>  30

Gly Gly Gly Phe Gln Leu Arg Gln Pro Pro Leu Val Pro Ser Arg Lys 
1               5                   10                  15      


Gly Glu 
        


<210>  31
<211>  410
<212>  PRT
<213>  Mycoplasma arginini

<300>
<308>  GenBank/ CAA38080.1
<309>  2004-09-09
<313>  (1)..(410)

<400>  31

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/ ABS32187.1
<309>  2007-07-25
<313>  (40)..(49)

<400>  32

Phe Leu Asp Thr Leu Val Val Leu His Arg 
1               5                   10  


<210>  33
<211>  38
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI NP_001182061.1
<309>  2011-02-19
<313>  (84)..(103)

<400>  33

Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
1               5                   10                  15      


Ala Gly Ala Arg Val Val Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg 
            20                  25                  30          


Arg Met Lys Trp Lys Lys 
        35              


<210>  34
<211>  13
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI NP_002746.1
<309>  2010-04-19
<313>  (1)..(12)

<400>  34

Gly Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn 
1               5                   10              


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank/ AAH03574.1
<309>  2006-07-15
<313>  (10)..(24)

<400>  35

Ala Val Thr Asp His Pro Asp Arg Leu Trp Ala Trp Glu Lys Phe 
1               5                   10                  15  


<210>  36
<211>  6
<212>  PRT
<213>  Homo sapiens

<300>
<302>  Transcription factor E2F DNA-binding domain inhibitor peptides 
       and their use
<308>  USPTO
<309>  2003-01-16
<310>  US6841385
<311>  2001-07-26
<312>  2003-01-16

<400>  36

Phe Trp Leu Arg Phe Thr 
1               5       


<210>  37
<211>  13
<212>  PRT
<213>  Homo sapiens

<300>
<301>  Pieraccini, S., Salamino, G., Cappelletti, G., Cartelli, D., 
       Francescato, P., Speranza, G., Manisto, P., Sironi, M
<302>  In silico design of tubulin - targeted antimitotic peptides
<303>  Nature Chemistry
<304>  23
<306>  642 - 648 
<307>  2009-09-23

<400>  37

Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Arg 
1               5                   10              


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<300>
<301>  Pieraccini, S., Salamino, G., Cappelletti, G., Cartelli, D., 
       Francescato, P., Speranza, G., Manisto, P., Sironi, M.,
<302>  In silico design of tubulin - targeted antimitotic peptides,
<303>  Nature Chemistry
<304>  1
<306>  642 - 648 
<307>  2009-10-23

<400>  38

Trp Cys Pro Thr Gly Phe Lys Val Gly Arg 
1               5                   10  


<210>  39
<211>  25
<212>  PRT
<213>  Apis mellifera

<300>
<308>  GenBank/ AAU87881.1
<309>  2004-10-04
<313>  (1)..(25)

<400>  39

Gly Ile Gly Ala Arg Leu Lys Val Leu Thr Thr Gly Leu Pro Arg Ile 
1               5                   10                  15      


Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25  


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial

<300>
<301>  Iwasaki T, Ishibashi J, Kubo M, Taylor D, Yamakawa M.
<302>  Multiple functions of short synthetic enantiomeric peptides based
        on beetle defensins
<303>  Biosci Biotechnol Biochem
<304>  73
<305>  3
<306>  683-687
<307>  2009-03-23

<400>  40

Ala Leu Tyr Leu Ala Ile 
1               5       


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<300>
<301>  Kono K, Ueba T, Takahashi JA, Murai N, Hashimoto N, Myoumoto A, 
       Itoh N,Fukumoto M
<302>  In vitro growth suppression of human glioma cells by a 16-mer 
       oligopeptide: a potential new treatment modality for malignant 
       glioma.
<303>  J Neurooncol
<304>  63
<305>  2
<306>  163-171
<307>  2003-07-30

<400>  41

Ala Pro Ser Gly His Tyr Lys Gly 
1               5               


<210>  42
<211>  15
<212>  PRT
<213>  Lasioglossum laticeps

<300>
<301>  Cerovsk V, Budesnsk M, Hovorka O, Cvacka J, Voburka Z, 
       Slaninov J, Borovickov L, Fuck V, Bednrov L, Votruba I, 
       Straka
<302>   Lasioglossins/ three novel antimicrobial peptides from the venom
        of the eusocial bee Lasioglossum laticeps (Hymenoptera/ 
       Halictidae).
<303>  JChembiochem.
<304>  10
<305>  12
<306>  2089-2099
<307>  2009-08-17

<400>  42

Val Asn Trp Lys Lys Val Leu Gly Lys Ile Ile Lys Val Ala Lys 
1               5                   10                  15  


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial

<300>
<301>  Pamonsinlapatham P, Hadj-Slimane R, Raynaud F, Bickle M, 
       Corneloup C, Barthelaix A, Lepelletier Y, Mercier P, Schapira M, 
       Samson J, Mathieu AL, Hugo N, Moncorg O, Mikaelian I, Dufour S, 
       Garbay C, Colas P.
<302>  A RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction 
       and induces caspase-independent tumor cell death
<303>  PLoS One
<304>  3
<305>  8)/e2902
<306>  doi:10.1371/journal.pone.0002902
<307>  2008-08-06

<400>  43

Lys Trp Val Val Ser His Ala Arg Leu Met Tyr Ser Phe 
1               5                   10              


<210>  44
<211>  27
<212>  PRT
<213>  Streptococcus pneumoniae

<300>
<301>  Dong Gun Lee1 , Kyung-Soo Hahm2 , Yoonkyung Park2 , Hai-Young 
       Kim3 , Weontae Lee3 , Sung-Chul Lim4 , Youn-Kyung Seo5  and 
       Cheol-Hee Choi5
<302>  Functional and structural characteristics of anticancer peptide 
       Pep27 analogues
<303>  Cancer Cell International
<304>  5
<305>  21
<306>  doi:10.1186/1475-2867-5-21
<307>  2005-07-11

<400>  44

Met Trp Lys Trp Phe His Asn Val Leu Ser Trp Trp Trp Leu Leu Ala 
1               5                   10                  15      


Asp Lys Arg Pro Ala Arg Asp Tyr Asn Arg Lys 
            20                  25          


<210>  45
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  45

Pro Leu Gly Leu Ala Gly 
1               5       


<210>  46
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  46

Arg Val Val Arg 
1               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  47

Cys Ala Ala Cys Ala Ala Ala Cys 
1               5               


<210>  48
<211>  17
<212>  PRT
<213>  Drosophila melanogaster

<300>
<301>  Derossi D, Calvet S, Trembleau A, Brunissen A, Chassaing G, 
       Prochiantz A
<302>  Cell
<303>  J Biol Chem
<304>  271
<305>  30
<306>  18188-93
<307>  1996-07-26

<400>  48

Asp Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210>  49
<211>  6
<212>  PRT
<213>  Drosophila melanogaster

<300>
<301>  Derossi D, Calvet S, Trembleau A, Brunissen A, Chassaing G, 
       Prochiantz A.
<302>  Cell internalization of the third helix of the Antennapedia 
       homeodomain is
<303>  J Biol Chem
<304>  271
<305>  30
<306>  18188-93
<307>  1996-07-26

<400>  49

Lys Pro Arg Arg Pro Tyr 
1               5       


<210>  50
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  50
ctgtctgaag acaaactgct ggcatgcggc gaaggcgcgg cagacattat catcggccac       60

ctgtgcattc gtcatgaaat gacgccggtt aacccgggtc gtgttgttcg tgaacgtggt      120

ccgcaacgcg ttgcggcaca tattacgggt acccgtggcc gcagcaacac gctgagctct      180

ccgaattcga aaaatgaaaa agcactgggc cgcaaaatta actcgtggga aagcagtcgt      240

tctggtcaca gctttctgtc gaatctgcac ctgcgcaatg gtgaactggt gattcatgaa      300

aaaggctttt actatatcta ttctcagacg tattttcgtt ttcaggaaga aattaaagaa      360

aacaccaaaa atgacaaaca gatggtgcag tacatttaca aatacaccag ttacccggac      420

ccgattctgc tgatgaaaag cgcccgtaac tcatgctgga gcaaagacgc tgaatatggc      480

ctgtattcta tttatcaggg tggcatcttc gaactgaaag aaaacgatcg tatttttgtt      540

tcggtgacca acgaacacct gattgatatg gatcatgaag catcgttttt cggcgcgttt      600

ctggtcggc                                                              609


<210>  51
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  51
gaaatgacgc cggtgaatcc gggtcgtgtt gttcgtgaac gtggtccgca acgcgttgcg       60

gcacatatta cgggtacccg tggccgcagc aacacgctga gctctccgaa ttcgaaaaat      120

gaaaaagcac tgggccgcaa aattaactcg tgggaaagca gtcgttctgg tcacagcttt      180

ctgtcgaatc tgcacctgcg caatggtgaa ctggtgattc atgaaaaagg cttttactat      240

atctattctc agacgtattt tcgttttcag gaagaaatta aagaaaacac caaaaatgac      300

aaacagatgg tgcagtacat ttacaaatac accagttacc cggacccgat tctgctgatg      360

aaaagcgccc gtaactcatg ctggagcaaa gacgctgaat atggcctgta ttctatttat      420

cagggtggca tcttcgaact gaaagaaaac gatcgtattt ttgtttcggt gaccaacgaa      480

cacctgattg atatggatca tgaagcatcg tttttcggcg cgtttctggt cggc            534


<210>  52
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  52
cgtgttgcag cacatattac cggcacccgt ggtcgtagca ataccctgag cagcccgaat       60

agcaaaaatg aaaaagccct gggtcgcaaa attaatagct gggaaagcag ccgtagcggt      120

catagctttc tgagcaatct gcatctgcgt aatggtgaac tggtgattca tgaaaaaggc      180

ttttattata tttatagcca gacctatttt cgctttcagg aagaaattaa agaaaatacc      240

aaaaatgata aacaaatggt gcagtatatc tataaatata ccagctatcc ggatccgatt      300

ctgctgatga aaagcgcacg taatagctgt tggagcaaag atgcagaata tggcctgtat      360

agcatttatc agggtggcat ttttgaactg aaagaaaatg atcgcatttt tgtgagcgtg      420

accaatgaac atctgattga tatggatcat gaagccagct tttttggtgc atttctggtt      480

ggtccgctgg gtctggcagg tcgtgttgtt cgtgaaatga caccggttaa tccgggt         537


<210>  53
<211>  612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  53
cgtgttgcag cacatattac cggcacccgt ggtcgtagca ataccctgag cagcccgaat       60

agcaaaaatg aaaaagccct gggtcgcaaa attaatagct gggaaagcag ccgtagcggt      120

catagctttc tgagcaatct gcatctgcgt aatggtgaac tggtgattca tgaaaaaggc      180

ttttattata tttatagcca gacctatttt cgctttcagg aagaaattaa agaaaatacc      240

aaaaatgata aacaaatggt gcagtatatc tataaatata ccagctatcc ggatccgatt      300

ctgctgatga aaagcgcacg taatagctgt tggagcaaag atgcagaata tggcctgtat      360

agcatttatc agggtggcat ttttgaactg aaagaaaatg atcgcatttt tgtgagcgtg      420

accaatgaac atctgattga tatggatcat gaagccagct tttttggtgc atttctggtt      480

ggtccgctgg gtctggcagg tcgtgttgtt cgtctgagcg aagataaact gctggcatgt      540

ggtgaaggtg cagccgatat tattattggc catctgtgca ttcgtcatga aatgacaccg      600

gttaatccgg gt                                                          612


<210>  54
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  54
ctgagcgaag ataaactgct ggcatgtggt gaaggtgcag cagatattat tattggtcat       60

ctgtgcattc gccatgaaat gacaccggtt aatccgggtc gtgttgttcg tcctctgggt      120

ctggcaggca ccagcgaaga aaccattagc accgttcagg aaaaacagca gaatattagt      180

ccgctggttc gtgaacgtgg tccgcagcgt gttgcagcac atattaccgg cacccgtggt      240

cgtagcaata ccctgagcag cccgaatagc aaaaatgaaa aagcactggg tcgcaaaatt      300

aatagctggg aaagcagccg tagcggtcat agctttctga gcaatctgca tctgcgtaat      360

ggtgaactgg tgattcatga aaaaggcttt tattatattt atagccagac ctattttcgc      420

tttcaggaag aaattaaaga aaataccaaa aatgataaac aaatggtgca gtatatctat      480

aaatacacca gctatccgga tccgattctg ctgatgaaaa gcgcacgtaa tagctgttgg      540

agcaaagatg cagaatatgg tctgtatagc atttatcagg gtggcatttt tgaactgaaa      600

gaaaatgatc gcatttttgt gagcgtgacc aatgaacatc tgattgatat ggatcatgaa      660

gccagctttt ttggtgcatt tctggtgggt                                       690


<210>  55
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  55
accagcgaag aaaccattag caccgttcaa gaaaaacagc agaatattag tccgctggtt       60

cgtgaacgtg gtccgcagcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagcactgg gtcgcaaaat caatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ctactatatc tatagccaga cctatttccg cttccaagaa      300

gaaatcaaag aaaataccaa aaatgataaa caaatggtgc agtatattta caaatatacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcatct ttgagctgaa agaaaatgat      480

cgcatctttg ttagcgtgac caacgaacat ctgatcgata tggatcatga agccagcttt      540

tttggtgcat ttctggttgg ttgtgcagca tgtgcagccg catgtccgct gggtctggca      600

ggtcgtgttg ttcgtctgag cgaagataaa ctgctggcat gtggtgaagg tgcagcagat      660

attatcattg gtcatctgtg cattcgccat gaaatgacac cggttaatcc gggt            714


<210>  56
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  56
accagcgaag aaaccattag caccgttcaa gaaaaacagc agaatattag tccgctggtt       60

cgtgaacgtg gtccgcagcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagcactgg gtcgcaaaat caatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ctactatatc tatagccaga cctatttccg cttccaagaa      300

gaaatcaaag aaaataccaa aaatgataaa caaatggtgc agtatattta caaatatacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcatct ttgagctgaa agaaaatgat      480

cgcatctttg ttagcgtgac caacgaacat ctgatcgata tggatcatga agccagcttt      540

tttggtgcat ttctggttgg ttgtgcagca tgtgcagccg catgtccgct gggtctggca      600

ggtcgtgttg ttcgtgaaat gacaccggtt aatccgggt                             639


<210>  57
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  57
aaacgtcgtc agaccagcgc aaccgatttt tatcatagca aacgtcgcct gatttttagc       60

aaaccgcgtc gtccgtatcg tgttgttcgt ccgctgggtc tggcaggtcg tgttgcagca      120

catattaccg gcacccgtgg tcgtagcaat accctgagca gcccgaatag caaaaatgaa      180

aaagccctgg gtcgcaaaat taatagctgg gaaagcagcc gtagcggtca tagctttctg      240

agcaatctgc atctgcgtaa tggtgaactg gtgattcatg aaaaaggctt ttattatatt      300

tatagccaga cctattttcg ctttcaggaa gaaattaaag aaaataccaa aaatgataaa      360

caaatggtgc agtacattta taaatatacc agctatccgg atccgattct gctgatgaaa      420

agcgcacgta atagctgttg gagcaaagat gcagaatatg gcctgtatag catttatcag      480

ggtggcattt ttgaactgaa agaaaatgat cgcatttttg tgagcgtgac caatgaacat      540

ctgattgata tggatcatga agccagcttt tttggtgcat ttctggtggg c               591


<210>  58
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  58
accagcgaag aaaccattag caccgttcaa gaaaaacagc agaatattag tccgctggtt       60

cgtgaacgtg gtccgcagcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagcactgg gtcgcaaaat caatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ttattatatt tatagccaga cctattttcg ctttcaagaa      300

gagattaaag aaaataccaa aaatgataaa caaatggtgc agtatatcta taaatatacc      360

agctatccgg atccgatcct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcatct ttgagctgaa agaaaatgat      480

cgcatctttg ttagcgtgac caacgaacat ctgatcgata tggatcatga agccagcttt      540

tttggtgcat ttctggttgg ttgtgcagca tgtgcagccg catgtccgct gggtctggca      600

ggtcgtgttg ttcgtaaacg tcgtcagacc agcgcaaccg atttttatca tagcaaacgt      660

cgcctgatct ttagcaaacc gcgtcgtccg tat                                   693


<210>  59
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  59
atgtggtacc gtccggacct ggacgaacgt aaacagcaga aacgtgaacg tgttgttcgt       60

ccgctgggtc tggcgggtgg tggttgcgcg gcggcgtgcg cggcgtgcgg tggtcagcgt      120

gttgcggcgc acatcaccgg tacccgtggt cgttctaaca ccctgtcttc tccgaactct      180

aaaaacgaaa aagcgctggg tcgtaaaatc aactcttggg aatcttctcg ttctggtcac      240

tctttcctgt ctaacctgca cctgcgtaac ggtgaactgg ttatccacga aaaaggtttc      300

tactacatct actctcagac ctacttccgt ttccaggaag aaatcaaaga aaacaccaaa      360

aacgacaaac agatggttca gtacatctac aaatacacct cttacccgga cccgatcctg      420

ctgatgaaat ctgcgcgtaa ctcttgctgg tctaaagacg cggaatacgg tctgtactct      480

atctaccagg gtggtatctt cgaactgaaa gaaaacgacc gtatcttcgt ttctgttacc      540

aacgaacacc tgatcgacat ggaccacgaa gcgtctttct tcggtgcgtt cctggttggt      600


<210>  60
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  60
accagcgaag aaaccattag caccgttcaa gaaaaacagc agaatattag tccgctggtt       60

cgtgaacgtg gtccgcagcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagcactgg gtcgcaaaat caatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ctactatatc tatagccaga cctatttccg cttccaagaa      300

gaaatcaaag aaaataccaa aaatgataaa caaatggtgc agtatattta caaatatacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcatct ttgagctgaa agaaaatgat      480

cgcatctttg ttagcgtgac caacgaacat ctgatcgata tggatcatga agccagcttt      540

tttggtgcat ttctggttgg ttgtgcagca tgtgcagccg catgtggtgg tggtccgctg      600

ggtctggcag gtcgtgttgt tcgtcgtcgt cgccgtcgtc ggcgtggtgg tggttttcag      660

ctgcgtcagc ctccgctggt tccgagccgt aaaggtgaa                             699


<210>  61
<211>  1770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  61
cgtgttgcag cacatattac cggcacccgt ggtcgtagca ataccctgag cagcccgaat       60

agcaaaaatg aaaaagcact gggtcgcaaa atcaatagct gggaaagcag ccgtagcggt      120

catagctttc tgagcaatct gcatctgcgt aatggtgaac tggtgattca tgaaaaaggc      180

ttttattata tttatagcca gacctatttt cgctttcaag aagagattaa agaaaatacc      240

aaaaatgata aacaaatggt gcagtatatc tataaatata ccagctatcc ggacccgatt      300

ctgctgatga aaagcgcacg taatagctgt tggagcaaag atgcagaata tggtctgtat      360

agcatttatc agggtggcat ctttgagctg aaagaaaatg atcgcatctt tgttagcgtg      420

accaacgaac atctgatcga tatggatcat gaagccagct tttttggtgc atttctggtt      480

ggtggtggta gcggtccgct gggtctggca ggtcgtgttg ttcgtggtgg tggttcaggt      540

atgagcgttt ttgatagcaa attcaaaggc atccacgtgt atagcgaaat tggtgagctg      600

gaaagcgttc tggttcatga accgggtcgt gaaattgatt atattacacc ggcacgtctg      660

gatgaactgc tgtttagcgc aattctggaa agccatgatg cacgtaaaga acataaacag      720

tttgtggcag aactgaaagc caacgatatt aatgtggtgg aactgattga tctggttgca      780

gaaacctatg atctggcaag ccaagaagca aaagataaac tgatcgaaga atttctggaa      840

gatagcgaac cggttctgag cgaagaacat aaagttgttg tgcgcaattt tctgaaagcc      900

aaaaaaacca gccgtgaact ggtggaaatt atgatggcag gcatcaccaa atatgatctg      960

ggtattgaag ccgatcatga actgattgtt gatccgatgc cgaatctgta ttttacccgt     1020

gatccgtttg caagcgttgg taatggtgtt accattcatt acatgcgtta taaagtgcgt     1080

cagcgtgaaa ccctgtttag ccgttttgtt tttagcaatc acccgaaact gattaatacc     1140

ccgtggtatt atgatccgag cctgaaactg agcattgaag gtggtgatgt gttcatctat     1200

aacaatgata ccctggttgt tggtgttagc gaacgtaccg atctgcagac cgttaccctg     1260

ctggcaaaaa atattgtggc caataaagaa tgcgaattta aacgcattgt ggccattaat     1320

gttccgaaat ggaccaatct gatgcatctg gatacctggc tgaccatgct ggataaagac     1380

aaatttctgt atagcccgat tgccaacgac gtgtttaaat tttgggatta tgacctggtt     1440

aatggtggtg cagaaccgca gccggttgaa aatggtctgc cgctggaagg tctgctgcag     1500

agcattatta ataaaaaacc ggtgctgatt ccgattgccg gtgaaggtgc aagccagatg     1560

gaaattgaac gtgaaaccca ttttgatggc accaattatc tggcaattcg tccgggtgtt     1620

gttattggtt atagccgtaa tgagaaaacc aatgcagcac tggaagcagc aggtattaaa     1680

gttctgccgt ttcatggtaa tcagctgagc ctgggtatgg gtaatgcacg ttgtatgagc     1740

atgccgctga gccgtaaaga tgttaaatgg                                      1770


<210>  62
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  62
tttctggata ccctggttgt tctgcatcgt aaaccgcgtc gtccgtatcg tgttgttcgt       60

ccgctgggtc tggcaggtcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagcactgg gtcgcaaaat taatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ttattatatt tatagccaga cctattttcg ctttcaggaa      300

gaaattaaag aaaataccaa aaatgataaa caaatggtgc agtacattta caaatatacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcattt ttgaactgaa agaaaatgat      480

cgcatttttg tgagcgtgac caatgaacat ctgattgata tggatcatga agccagcttt      540

tttggtgcat ttctggttgg t                                                561


<210>  63
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  63
cgtgtggcag cacatattac cggcacccgt ggtcgtagca ataccctgag cagcccgaat       60

agcaaaaatg aaaaagcact gggtcgcaaa attaatagct gggaaagcag ccgtagcggt      120

catagctttc tgagcaatct gcatctgcgt aatggtgaac tggtgattca tgaaaaaggc      180

ttttattata tttatagcca gacctatttt cgctttcagg aagaaattaa agaaaatacc      240

aaaaatgata aacaaatggt gcagtatatc tataaatata ccagctatcc ggatccgatt      300

ctgctgatga aaagcgcacg taatagctgt tggagcaaag atgcagaata tggtctgtat      360

agcatttatc agggtggcat ttttgaactg aaagaaaatg atcgcatttt tgtgagcgtg      420

accaatgaac atctgattga tatggatcat gaagccagct tttttggtgc atttctggtt      480

ggtggtagtc cgctgggtct ggcaggtcgt gttgttcgtg atcgtcagat taaaatttgg      540

tttcagaatc gtcgcatgaa atggaaaaaa ggcatgccga aaaaaaaacc gaccccgatt      600

cagctgaat                                                              609


<210>  64
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  64
cgtgtggcag cacatattac cggcacccgt ggtcgtagca ataccctgag cagcccgaat       60

agcaaaaatg aaaaagcact gggtcgcaaa attaatagct gggaaagcag ccgtagcggt      120

catagctttc tgagcaatct gcatctgcgt aatggtgaac tggtgattca tgaaaaaggc      180

ttttattata tttatagcca gacctatttt cgctttcagg aagaaattaa agaaaatacc      240

aaaaatgata aacaaatggt gcagtatatc tataaatata ccagctatcc ggatccgatt      300

ctgctgatga aaagcgcacg taatagctgt tggagcaaag atgcagaata tggtctgtat      360

agcatttatc agggtggcat ttttgaactg aaagaaaatg atcgcatttt tgtgagcgtg      420

accaatgaac atctgattga tatggatcat gaagccagct tttttggtgc atttctggtt      480

ggtggtagtc cgctgggtct ggcaggtcgt gttgttcgtg atcgtcagat taaaatttgg      540

tttcagaatc gtcgcatgaa atggaaaaaa gcagttaccg atcatccgga tcgtctgtgg      600

gcatgggaaa aattt                                                       615


<210>  65
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  65
ttttggctgc gttttaccaa accgcgtcgt ccgtatcgtg ttgttcgtcc gctgggtctg       60

gcaggtcgtg ttgcagcaca tattaccggc acccgtggtc gtagcaatac cctgagcagc      120

ccgaatagca aaaatgaaaa agcactgggt cgcaaaatta atagctggga aagcagccgt      180

agcggtcata gctttctgag caatctgcat ctgcgtaatg gtgaactggt gattcatgaa      240

aaaggctttt attatattta tagccagacc tattttcgct ttcaggaaga aattaaagaa      300

aataccaaaa atgataaaca aatggtgcag tacatttaca aatataccag ctatccggat      360

ccgattctgc tgatgaaaag cgcacgtaat agctgttgga gcaaagatgc agaatatggt      420

ctgtatagca tttatcaggg tggcattttt gaactgaaag aaaatgatcg catttttgtg      480

agcgtgacca atgaacatct gattgatatg gatcatgaag ccagcttttt tggtgcattt      540

ctggttggt                                                              549


<210>  66
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  66
tttcgtcgta aagcatttct gcattggtat accggtcgtc gtcgccgtcg ccgtcgtcgt       60

gttgttcgtc ctctgggtct ggcaggtcgt gttgcagcac atattaccgg cacccgtggt      120

cgtagcaata ccctgagcag cccgaatagc aaaaatgaga aagcactggg tcgcaaaatc      180

aatagctggg aaagcagccg tagcggtcat agctttctga gcaatctgca tctgcgtaat      240

ggtgaactgg tgattcacga gaaaggcttc tattacatct atagccagac ctatttccgc      300

ttccaagagg aaattaaaga gaacaccaaa aacgacaaac aaatggtgca gtatatctat      360

aaatatacca gctatccgga tccgattctg ctgatgaaaa gcgcacgtaa tagctgttgg      420

agcaaagatg cagaatatgg tctgtatagc atttatcagg gtggcatttt tgaactgaaa      480

gaaaatgatc gcatttttgt gagcgtgacc aatgaacatc tgattgatat ggatcatgaa      540

gccagctttt ttggtgcatt tctggtgggt                                       570


<210>  67
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  67
tggtgtccga ccggttttaa agttggacgc cgtcgtcgtc gccgtcgtcg tgttgttcgt       60

cctctgggtc tggcaggtcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgag aaagcactgg gtcgcaaaat taacagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg agaaaggctt ctattatatc tatagccaga cctattttcg ctttcaagag      300

gaaattaaag agaataccaa aaacgataaa caaatggtgc agtacatcta taaatacacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcattt ttgaactgaa agaaaatgat      480

cgcatttttg tgagcgtgac caatgaacat ctgattgata tggatcatga agccagcttt      540

tttggtgcat ttctggtggg t                                                561


<210>  68
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  68
ggcattggtg cacgtctgaa agttctgacc accggtctgc ctcgtattag ctggattaaa       60

cgtaaacgtc agcagcgtgt tgttcgtccg ctgggtctgg caggtcgtgt tgcagcacat      120

attaccggca cccgtggtcg tagcaatacc ctgagcagcc cgaatagcaa aaatgaaaaa      180

gcactgggtc gcaaaattaa tagctgggaa agcagccgta gcggtcatag ctttctgagc      240

aatctgcatc tgcgtaatgg tgaactggtg attcatgaaa aaggctttta ttatatttat      300

agccagacct attttcgctt tcaggaagaa attaaagaaa ataccaaaaa tgataaacaa      360

atggtgcagt acatttacaa atataccagc tatccggatc cgattctgct gatgaaaagc      420

gcacgtaata gctgttggag caaagatgca gaatatggtc tgtatagcat ttatcagggt      480

ggcatttttg aactgaaaga aaatgatcgc atttttgtga gcgtgaccaa tgaacatctg      540

attgatatgg atcatgaagc cagctttttt ggtgcatttc tggttggt                   588


<210>  69
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  69
gcactgtatc tggcaattcg tcgtcgtcgt cgccgtcgtc gtgttgttcg tccgctgggt       60

ctggcaggtc gtgttgcagc acatattacc ggcacccgtg gtcgtagcaa taccctgagc      120

agcccgaata gcaaaaatga aaaagcactg ggtcgcaaaa ttaatagctg ggaaagcagc      180

cgtagcggtc atagctttct gagcaatctg catctgcgta atggtgaact ggtgattcat      240

gaaaaaggct tttattatat ttatagccag acctattttc gctttcaaga agaaattaaa      300

gagaatacca aaaacgataa gcagatggtg cagtacattt ataaatatac cagctatccg      360

gatccgattc tgctgatgaa aagcgcacgt aatagctgtt ggagcaaaga tgcagaatat      420

ggtctgtata gcatttatca gggtggcatt tttgaactga aagaaaatga tcgcattttt      480

gtgagcgtga ccaatgaaca tctgattgat atggatcatg aagccagctt ttttggtgca      540

tttctggtgg gt                                                          552


<210>  70
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  70
gcccccagtg gacattataa gggaagggtc gtcaggcccc taggactagc cggagccccc       60

agtggacatt ataagggagg aggaagggtc gccgcccata taacaggaac aaggggaagg      120

agtaatacac taagtagtcc caatagtaag aatgagaagg ccctaggaag gaagataaat      180

agttgggaga gtagtaggag tggacatagt tttctaagta atctacatct aaggaatgga      240

gagctagtca tacatgagaa gggattttat tatatatata gtcaaacata ttttaggttt      300

caagaggaga taaaggagaa tacaaagaat gataagcaaa tggtccaata tatatataag      360

tatacaagtt atcccgatcc catactacta atgaagagtg ccaggaatag ttgttggagt      420

aaggatgccg agtatggact atatagtata tatcaaggag gaatatttga gctaaaggag      480

aatgatagga tatttgtcag tgtcacaaat gagcatctaa tagatatgga tcatgaggcc      540

agtttttttg gagcctttct agtcgga                                          567


<210>  71
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  71
gtgaattgga aaaaagtgct gggcaaaatt attaaagtgg ccaaacgtgt tgttcgtccg       60

ctgggtctgg caggtccgca gcgtgttgca gcacatatta ccggcacccg tggtcgtagc      120

aataccctga gcagcccgaa tagcaaaaat gaaaaagcac tgggtcgcaa aatcaatagc      180

tgggaaagca gccgtagcgg tcatagcttt ctgagcaatc tgcatctgcg taatggtgaa      240

ctggtgattc atgaaaaagg cttttattat atttatagcc agacctattt tcgctttcaa      300

gaagagatta aagaaaatac caaaaatgac aaacaaatgg tgcaatatat ctacaaatat      360

accagctatc cggacccgat tctgctgatg aaaagcgcac gtaatagctg ttggagcaaa      420

gatgcagaat atggtctgta tagcatttat cagggtggca tctttgagct gaaagaaaat      480

gatcgcatct ttgttagcgt gaccaacgaa catctgatcg atatggatca tgaagccagc      540

ttttttggtg catttctggt gggt                                             564


<210>  72
<211>  579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  72
aaatgggttg ttagccatgc acgtctgatg tatagctttc gtcgtcgtcg ccgtcggcgt       60

cgtcgtgttg ttcgtccgct gggtctggca ggttgtcgtg ttgcagcaca tattaccggc      120

acccgtggtc gtagcaatac cctgagcagc ccgaatagca aaaatgaaaa agcactgggt      180

cgcaaaatca atagctggga aagcagccgt agcggtcata gctttctgag caatctgcat      240

ctgcgtaatg gtgaactggt gattcatgaa aaaggctttt attatattta tagccagacc      300

tattttcgct ttcaagaaga gattaaagaa aataccaaaa atgacaaaca aatggtgcaa      360

tatatctaca aatataccag ctatccggac ccgattctgc tgatgaaaag cgcacgtaat      420

agctgttgga gcaaagatgc agaatatggt ctgtatagca tttatcaggg tggcatcttt      480

gagctgaaag aaaatgatcg catctttgtt agcgtgacca acgaacatct gatcgatatg      540

gatcatgaag ccagcttttt tggtgcattt ctggtgggt                             579


<210>  73
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  73
accagcgaag aaaccattag caccgttcaa gaaaaacagc agaatattag tccgctggtt       60

cgtgaacgtg gtccgcagcg tgttgcagca catattaccg gcacccgtgg tcgtagcaat      120

accctgagca gcccgaatag caaaaatgaa aaagcactgg gtcgcaaaat caatagctgg      180

gaaagcagcc gtagcggtca tagctttctg agcaatctgc atctgcgtaa tggtgaactg      240

gtgattcatg aaaaaggctt ctactatatc tatagccaga cctatttccg cttccaagaa      300

gaaatcaaag aaaataccaa aaatgataaa caaatggtgc agtatattta caaatatacc      360

agctatccgg atccgattct gctgatgaaa agcgcacgta atagctgttg gagcaaagat      420

gcagaatatg gtctgtatag catttatcag ggtggcatct ttgagctgaa agaaaatgat      480

cgcatctttg ttagcgtgac caacgaacat ctgatcgata tggatcatga agccagcttt      540

tttggtgcat ttctggttgg ttgtgcagca tgtgcagccg catgtccgct gggtctggca      600

ggtcgtgttg ttcgtgatgc agcacgtgaa ggttttctgg ataccctggt tgttctgcat      660

cgtgccggtg cacgtgttgt gcgtcagatt aaaatctggt ttcagaatcg tcgcatgaaa      720

tggaaaaag                                                              729


<210>  74
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  74
atgtggaaat ggtttcataa tgttctgagc tggtggtggc tgctggcaga taaacgtccg       60

gcacgtgatt ataatcgtaa acgtgttgtt cgtccgctgg gtctggcagg tcagcgtgtt      120

gcagcacata ttaccggtac ccgtggtcgt agcaataccc tgagcagccc gaatagcaaa      180

aatgaaaaag cactgggtcg taaaattaat agctgggaaa gcagccgtag cggtcatagc      240

tttctgagca atctgcatct gcgtaatggt gaactggtta ttcatgaaaa aggtttttat      300

tatatttata gccagaccta ttttcgtttt caggaagaaa ttaaagaaaa taccaaaaat      360

gataaacaga tggttcagta tatttataaa tataccagct atccggatcc gattctgctg      420

atgaaaagcg cacgtaatag ctgttggagc aaagatgcag aatatggtct gtatagcatt      480

tatcagggtg gtatttttga actgaaagaa aatgatcgta tttttgttag cgttaccaat      540

gaacatctga ttgatatgga tcatgaagca agcttttttg gtgcatttct ggttggt         597


<210>  75
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  75

Lys Arg Arg Gln Thr Ser Ala Thr Asp Phe Tyr His Ser Lys Arg Arg 
1               5                   10                  15      


Leu Ile Phe Ser Lys Pro Arg Arg Pro Tyr Arg Val Val Arg Pro Leu 
            20                  25                  30          


Gly Leu Ala Gly Gly Gly Gly Cys Ala Ala Ala Cys Ala Ala Cys Gly 
        35                  40                  45              


Ser Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
    50                  55                  60                  


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
65                  70                  75                  80  


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
                85                  90                  95      


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
        115                 120                 125             


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
    130                 135                 140                 


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
145                 150                 155                 160 


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
                165                 170                 175     


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
            180                 185                 190         


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
        195                 200                 205             


Phe Leu Val Gly 
    210         


<210>  76
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  76
aaacgtcgtc agaccagcgc aaccgatttt tatcatagca aacgtcgcct gatttttagc       60

aaaccgcgtc gtccgtatcg tgttgttcgt ccgctgggta ttgccggtgg tggtggttgt      120

gcagcagcat gtgcagcctg tggtagcggt cagcgtgttg cagcacatat taccggcacc      180

cgtggtcgta gcaataccct gagcagcccg aatagcaaaa atgaaaaagc actgggtcgc      240

aaaattaaca gctgggaaag cagccgtagt ggtcatagct ttctgagcaa tctgcatctg      300

cgtaatggtg aactggtgat tcatgaaaaa ggcttctact atatctacag ccagacctat      360

tttcgcttcc aagaagagat taaagaaaac accaaaaacg ataaacaaat ggtgcagtac      420

atctataaat acaccagcta tccggatccg attctgctga tgaaaagcgc acgtaatagc      480

tgttggagca aagatgcaga atatggcctg tatagcattt atcagggtgg catctttgaa      540

ctgaaagaaa acgatcgtat tttcgtgagc gtgaccaatg aacatctgat cgatatggat      600

catgaagcca gcttttttgg tgcatttctg gtgggt                                636


<210>  77
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  77

Gly Gly Gly Cys Ala Ala Ala Cys Ala Ala Cys Gly Ser Gly 
1               5                   10                  


<210>  78
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


