                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR 
       PREVENTION OF MALARIA

<130>  709937

<150>  US 61/474,583
<151>  2011-04-12

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  4254
<212>  DNA
<213>  Plasmodium falciparum

<400>  1
atggtttcat tttttaaaac tccaatcttt attttaatta tctttttata cttaaatgaa       60

aaggtaatat gttcaataaa tgaaaatcaa aatgaaaatg ataccattag tcaaaatgtc      120

aaccaacatg aaaatattaa tcaaaatgta aatgataatg acaatattga acaattaaaa      180

tccatgattg gaaatgatga actacataag aatttaacaa tattagaaaa attaatttta      240

gagtctttag aaaaagataa attaaaatat cctctcctta aacaaggaac tgaacaattg      300

atagatatat caaaatttaa taaaaaaaat attacagatg cggatgatga aacgtacatc      360

atacccaccg tccaatcaac gtttcacgat attgtgaaat acgaacatct tataaaagaa      420

caatcaatag aaatttacaa ttctgatata tcagataaaa ttaagaaaaa aatttttata      480

gtaagaacat tgaaaaccat aaaattaatg cttataccat taaactcgta caaacaaaat      540

aatgacttga aatctgcact cgaagaatta aataatgtat ttacaaacaa agaagctcaa      600

gaggaaagca gtccaatagg cgaccatggg acattcttta gaaaattgtt aacacatgtt      660

agaacaatta aagaaaatga agatatagaa aataaaggag aaacacttat attaggcgat      720

aataaaatag atgtaatgaa ttcaaacgat ttctttttta caaccaactc aaatgtaaaa      780

tttatggaaa atttagatga tataacaaat caatatggat taggtttgat taatcatcta      840

ggtcctcatt taatagcctt gggtcatttt accgtattaa aattagcact aaaaaattac      900

aaaaactatt ttgaagcaaa aagtattaaa ttttttagtt ggcaaaaaat tttagagttc      960

tccatgtctg atagatttaa agttcttgat atgatgtgtg accatgaatc tgtatactat     1020

tccgaaaaaa aacgtagaaa aacatattta aaagttgaca gatcaaatac atctatggaa     1080

tgtaatatat tggaatattt attacattat tttaataaat accaactaga aataattaaa     1140

actacacaag atactgattt tgacttacat ggtatgatgg aacataaata tataaaagat     1200

tatttctttt catttatgtg taatgatcct aaagaatgta ttatttatca tacgaatcaa     1260

tttaaaaaag aagccaacga agaaaacaca tttcctgaac aagaagaacc taaccgtcaa     1320

ataagtgcat ttaatttata tttaaattat tattatttca tgaaacgtta tagttcatat     1380

ggagtaaaaa agacattata tgttcattta ttaaatttaa ctggactttt aaattatgat     1440

acaagagcat acgtgacatc actttattta ccaggatatt acaacgctgt cgaaatgtct     1500

tttacggaag aaaaagagtt ttccaaactt tttgaaagct taatacaatg tattgaaaaa     1560

tgccattcag accaagcaag gcaaatatca aaagatagta atttacttaa taatataaca     1620

aaatgtgatt tgtgtaaagg agccttttta tatgctaata tgaaattcga tgaagttcct     1680

tcaatgttgc aaaaatttta cgtatattta actaaaggtc tcaaaataca aaaagtatca     1740

tcactaatca aaacgctaga tatatatcaa gattacagca attacttatc acatgatatt     1800

aattggtaca cattcctatt tttatttaga cttacaagtt ttaaagaaat tgcaaagaaa     1860

aatgttgctg aagcaatgta tttaaatata aaagatgaag acacattcaa caaaacggta     1920

gtaacaaact attggtaccc atctcctata aaaaaatatt atacattata tgttagaaaa     1980

catataccaa ataatttagt agatgaattg gagaaattaa tgaaaagtgg cactttagaa     2040

aaaatgaaaa aatctctcac ctttttagta catgtgaatt catttttaca attagatttt     2100

ttccatcaat taaatgaacc acctcttgga ttacctcgat catatccatt atcgttagtt     2160

ctcgaacata aatttaaaga atggatgaac agttcgccag caggtttcta tttttcaaat     2220

tatcaaaatc catatatcag aaaagatttg catgataaag ttttatcaca aaaatttgaa     2280

ccacctaaaa tgaatcagtg gaacaaagtt ttgaaatcat taattgaatg cgcatatgat     2340

atgtattttg aacagagaca tgttaaaaat ttatataaat atcataacat ttataatata     2400

aataacaaat taatgttaat gcgagattca atcgatttgt ataaaaacaa ttttgacgat     2460

gtgttatttt ttgcggatat atttaatatg agaaaatata tgacagctac accagtatat     2520

aaaaaagtaa aagacagagt gtaccataca ttgcatagta ttacaggaaa ttctgtcaat     2580

ttttataaat atggtattat atatggattt aaagtaaaca aagaaatatt aaaagaagtt     2640

gtcgatgaat tgtattccat ctataatttt aacaccgaca tatttacgga tacttccttt     2700

ttacaaaccg tttatttatt atttagaaga atagaagaaa cctataggac ccaaagaaga     2760

gatgataaaa ttagtgtgaa taacgttttt ttcatgaatg ttgctaataa ttattccaaa     2820

ttaaacaaag aagaaagaga aatcgaaata cataattcca tggcatcaag atattatgca     2880

aaaacgatgt ttgcagcatt tcaaatgtta ttttcaacaa tgttgagcaa caatgtagat     2940

aatcttgata aagcatatgg attaagtgaa aatatccaag tagcaacaag tacttccgct     3000

tttcttactt ttgcatatgt atataacgga agtataatgg atagtgtgac taacagttta     3060

ttgccaccat atgcgaagaa acctataaca caattaaaat atggaaaaac cttcgttttc     3120

tcaaactatt tcatgctagc atccaaaatg tatgatatgt taaattataa aaatttaagt     3180

cttttatgtg aatatcaggc tgtggcaagt gccaatttct actctgctaa aaaggtaggt     3240

cagtttcttg gaagaaaatt tttacccata actacatatt ttctagtaat gagaattagt     3300

tggacacatg cttttacaac tggacaacat ttgattagcg cttttggttc cccaagttct     3360

actgctaatg gtaaaagtaa tgctagtggt tataaatccc ctgaaagttt tttcttcact     3420

cacggacttg ctgctgaagc atccaaatat ttattttttt attttttcac aaatttatac     3480

cttgatgcct acaaatcttt tcctggagga tttggtcctg caataaaaga acaaactcaa     3540

catgttcaag aacaaaccta cgaacgcaaa ccgtcagttc atagttttaa tagaaatttt     3600

ttcatggaac tcgtaaatgg attcatgtat gccttttgtt tttttgcaat ttctcaaatg     3660

tatgcatatt ttgaaaatat taatttttat attacaagta atttccgttt cttggataga     3720

tattatggtg tattcaataa atattttata aactatgcca taattaaact taaagaaatt     3780

actagtgatc ttttaataaa atatgaacgt gaggcttatt taagtatgaa aaaatatggt     3840

tatttaggtg aagttattgc agctagactt tctccaaaag ataaaattat gaattatgtg     3900

cacgaaacta acgaagatat catgagtaat ttaagaagat atgatatgga aaatgctttc     3960

aaaaacaaaa tgtcaacata tgtagatgat tttgcttttt ttgatgattg cggaaaaaat     4020

gaacaatttt taaatgagag atgtgattat tgtcctgtaa ttgaagaggt cgaagaaaca     4080

caattattta ctaccactgg tgataaaaac actaataaga ccacggaaat aaaaaaacaa     4140

actagtacat atattgatac tgaaaaaatg aatgaagcgg attctgctga tagcgacgat     4200

gaaaaggatt ctgatactcc tgacgatgaa ttaatgatat cacgatttca ctaa           4254


<210>  2
<211>  1417
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Met Val Ser Phe Phe Lys Thr Pro Ile Phe Ile Leu Ile Ile Phe Leu 
1               5                   10                  15      


Tyr Leu Asn Glu Lys Val Ile Cys Ser Ile Asn Glu Asn Gln Asn Glu 
            20                  25                  30          


Asn Asp Thr Ile Ser Gln Asn Val Asn Gln His Glu Asn Ile Asn Gln 
        35                  40                  45              


Asn Val Asn Asp Asn Asp Asn Ile Glu Gln Leu Lys Ser Met Ile Gly 
    50                  55                  60                  


Asn Asp Glu Leu His Lys Asn Leu Thr Ile Leu Glu Lys Leu Ile Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Lys Asp Lys Leu Lys Tyr Pro Leu Leu Lys Gln Gly 
                85                  90                  95      


Thr Glu Gln Leu Ile Asp Ile Ser Lys Phe Asn Lys Lys Asn Ile Thr 
            100                 105                 110         


Asp Ala Asp Asp Glu Thr Tyr Ile Ile Pro Thr Val Gln Ser Thr Phe 
        115                 120                 125             


His Asp Ile Val Lys Tyr Glu His Leu Ile Lys Glu Gln Ser Ile Glu 
    130                 135                 140                 


Ile Tyr Asn Ser Asp Ile Ser Asp Lys Ile Lys Lys Lys Ile Phe Ile 
145                 150                 155                 160 


Val Arg Thr Leu Lys Thr Ile Lys Leu Met Leu Ile Pro Leu Asn Ser 
                165                 170                 175     


Tyr Lys Gln Asn Asn Asp Leu Lys Ser Ala Leu Glu Glu Leu Asn Asn 
            180                 185                 190         


Val Phe Thr Asn Lys Glu Ala Gln Glu Glu Ser Ser Pro Ile Gly Asp 
        195                 200                 205             


His Gly Thr Phe Phe Arg Lys Leu Leu Thr His Val Arg Thr Ile Lys 
    210                 215                 220                 


Glu Asn Glu Asp Ile Glu Asn Lys Gly Glu Thr Leu Ile Leu Gly Asp 
225                 230                 235                 240 


Asn Lys Ile Asp Val Met Asn Ser Asn Asp Phe Phe Phe Thr Thr Asn 
                245                 250                 255     


Ser Asn Val Lys Phe Met Glu Asn Leu Asp Asp Ile Thr Asn Gln Tyr 
            260                 265                 270         


Gly Leu Gly Leu Ile Asn His Leu Gly Pro His Leu Ile Ala Leu Gly 
        275                 280                 285             


His Phe Thr Val Leu Lys Leu Ala Leu Lys Asn Tyr Lys Asn Tyr Phe 
    290                 295                 300                 


Glu Ala Lys Ser Ile Lys Phe Phe Ser Trp Gln Lys Ile Leu Glu Phe 
305                 310                 315                 320 


Ser Met Ser Asp Arg Phe Lys Val Leu Asp Met Met Cys Asp His Glu 
                325                 330                 335     


Ser Val Tyr Tyr Ser Glu Lys Lys Arg Arg Lys Thr Tyr Leu Lys Val 
            340                 345                 350         


Asp Arg Ser Asn Thr Ser Met Glu Cys Asn Ile Leu Glu Tyr Leu Leu 
        355                 360                 365             


His Tyr Phe Asn Lys Tyr Gln Leu Glu Ile Ile Lys Thr Thr Gln Asp 
    370                 375                 380                 


Thr Asp Phe Asp Leu His Gly Met Met Glu His Lys Tyr Ile Lys Asp 
385                 390                 395                 400 


Tyr Phe Phe Ser Phe Met Cys Asn Asp Pro Lys Glu Cys Ile Ile Tyr 
                405                 410                 415     


His Thr Asn Gln Phe Lys Lys Glu Ala Asn Glu Glu Asn Thr Phe Pro 
            420                 425                 430         


Glu Gln Glu Glu Pro Asn Arg Gln Ile Ser Ala Phe Asn Leu Tyr Leu 
        435                 440                 445             


Asn Tyr Tyr Tyr Phe Met Lys Arg Tyr Ser Ser Tyr Gly Val Lys Lys 
    450                 455                 460                 


Thr Leu Tyr Val His Leu Leu Asn Leu Thr Gly Leu Leu Asn Tyr Asp 
465                 470                 475                 480 


Thr Arg Ala Tyr Val Thr Ser Leu Tyr Leu Pro Gly Tyr Tyr Asn Ala 
                485                 490                 495     


Val Glu Met Ser Phe Thr Glu Glu Lys Glu Phe Ser Lys Leu Phe Glu 
            500                 505                 510         


Ser Leu Ile Gln Cys Ile Glu Lys Cys His Ser Asp Gln Ala Arg Gln 
        515                 520                 525             


Ile Ser Lys Asp Ser Asn Leu Leu Asn Asn Ile Thr Lys Cys Asp Leu 
    530                 535                 540                 


Cys Lys Gly Ala Phe Leu Tyr Ala Asn Met Lys Phe Asp Glu Val Pro 
545                 550                 555                 560 


Ser Met Leu Gln Lys Phe Tyr Val Tyr Leu Thr Lys Gly Leu Lys Ile 
                565                 570                 575     


Gln Lys Val Ser Ser Leu Ile Lys Thr Leu Asp Ile Tyr Gln Asp Tyr 
            580                 585                 590         


Ser Asn Tyr Leu Ser His Asp Ile Asn Trp Tyr Thr Phe Leu Phe Leu 
        595                 600                 605             


Phe Arg Leu Thr Ser Phe Lys Glu Ile Ala Lys Lys Asn Val Ala Glu 
    610                 615                 620                 


Ala Met Tyr Leu Asn Ile Lys Asp Glu Asp Thr Phe Asn Lys Thr Val 
625                 630                 635                 640 


Val Thr Asn Tyr Trp Tyr Pro Ser Pro Ile Lys Lys Tyr Tyr Thr Leu 
                645                 650                 655     


Tyr Val Arg Lys His Ile Pro Asn Asn Leu Val Asp Glu Leu Glu Lys 
            660                 665                 670         


Leu Met Lys Ser Gly Thr Leu Glu Lys Met Lys Lys Ser Leu Thr Phe 
        675                 680                 685             


Leu Val His Val Asn Ser Phe Leu Gln Leu Asp Phe Phe His Gln Leu 
    690                 695                 700                 


Asn Glu Pro Pro Leu Gly Leu Pro Arg Ser Tyr Pro Leu Ser Leu Val 
705                 710                 715                 720 


Leu Glu His Lys Phe Lys Glu Trp Met Asn Ser Ser Pro Ala Gly Phe 
                725                 730                 735     


Tyr Phe Ser Asn Tyr Gln Asn Pro Tyr Ile Arg Lys Asp Leu His Asp 
            740                 745                 750         


Lys Val Leu Ser Gln Lys Phe Glu Pro Pro Lys Met Asn Gln Trp Asn 
        755                 760                 765             


Lys Val Leu Lys Ser Leu Ile Glu Cys Ala Tyr Asp Met Tyr Phe Glu 
    770                 775                 780                 


Gln Arg His Val Lys Asn Leu Tyr Lys Tyr His Asn Ile Tyr Asn Ile 
785                 790                 795                 800 


Asn Asn Lys Leu Met Leu Met Arg Asp Ser Ile Asp Leu Tyr Lys Asn 
                805                 810                 815     


Asn Phe Asp Asp Val Leu Phe Phe Ala Asp Ile Phe Asn Met Arg Lys 
            820                 825                 830         


Tyr Met Thr Ala Thr Pro Val Tyr Lys Lys Val Lys Asp Arg Val Tyr 
        835                 840                 845             


His Thr Leu His Ser Ile Thr Gly Asn Ser Val Asn Phe Tyr Lys Tyr 
    850                 855                 860                 


Gly Ile Ile Tyr Gly Phe Lys Val Asn Lys Glu Ile Leu Lys Glu Val 
865                 870                 875                 880 


Val Asp Glu Leu Tyr Ser Ile Tyr Asn Phe Asn Thr Asp Ile Phe Thr 
                885                 890                 895     


Asp Thr Ser Phe Leu Gln Thr Val Tyr Leu Leu Phe Arg Arg Ile Glu 
            900                 905                 910         


Glu Thr Tyr Arg Thr Gln Arg Arg Asp Asp Lys Ile Ser Val Asn Asn 
        915                 920                 925             


Val Phe Phe Met Asn Val Ala Asn Asn Tyr Ser Lys Leu Asn Lys Glu 
    930                 935                 940                 


Glu Arg Glu Ile Glu Ile His Asn Ser Met Ala Ser Arg Tyr Tyr Ala 
945                 950                 955                 960 


Lys Thr Met Phe Ala Ala Phe Gln Met Leu Phe Ser Thr Met Leu Ser 
                965                 970                 975     


Asn Asn Val Asp Asn Leu Asp Lys Ala Tyr Gly Leu Ser Glu Asn Ile 
            980                 985                 990         


Gln Val Ala Thr Ser Thr Ser Ala  Phe Leu Thr Phe Ala  Tyr Val Tyr 
        995                 1000                 1005             


Asn Gly  Ser Ile Met Asp Ser  Val Thr Asn Ser Leu  Leu Pro Pro 
    1010                 1015                 1020             


Tyr Ala  Lys Lys Pro Ile Thr  Gln Leu Lys Tyr Gly  Lys Thr Phe 
    1025                 1030                 1035             


Val Phe  Ser Asn Tyr Phe Met  Leu Ala Ser Lys Met  Tyr Asp Met 
    1040                 1045                 1050             


Leu Asn  Tyr Lys Asn Leu Ser  Leu Leu Cys Glu Tyr  Gln Ala Val 
    1055                 1060                 1065             


Ala Ser  Ala Asn Phe Tyr Ser  Ala Lys Lys Val Gly  Gln Phe Leu 
    1070                 1075                 1080             


Gly Arg  Lys Phe Leu Pro Ile  Thr Thr Tyr Phe Leu  Val Met Arg 
    1085                 1090                 1095             


Ile Ser  Trp Thr His Ala Phe  Thr Thr Gly Gln His  Leu Ile Ser 
    1100                 1105                 1110             


Ala Phe  Gly Ser Pro Ser Ser  Thr Ala Asn Gly Lys  Ser Asn Ala 
    1115                 1120                 1125             


Ser Gly  Tyr Lys Ser Pro Glu  Ser Phe Phe Phe Thr  His Gly Leu 
    1130                 1135                 1140             


Ala Ala  Glu Ala Ser Lys Tyr  Leu Phe Phe Tyr Phe  Phe Thr Asn 
    1145                 1150                 1155             


Leu Tyr  Leu Asp Ala Tyr Lys  Ser Phe Pro Gly Gly  Phe Gly Pro 
    1160                 1165                 1170             


Ala Ile  Lys Glu Gln Thr Gln  His Val Gln Glu Gln  Thr Tyr Glu 
    1175                 1180                 1185             


Arg Lys  Pro Ser Val His Ser  Phe Asn Arg Asn Phe  Phe Met Glu 
    1190                 1195                 1200             


Leu Val  Asn Gly Phe Met Tyr  Ala Phe Cys Phe Phe  Ala Ile Ser 
    1205                 1210                 1215             


Gln Met  Tyr Ala Tyr Phe Glu  Asn Ile Asn Phe Tyr  Ile Thr Ser 
    1220                 1225                 1230             


Asn Phe  Arg Phe Leu Asp Arg  Tyr Tyr Gly Val Phe  Asn Lys Tyr 
    1235                 1240                 1245             


Phe Ile  Asn Tyr Ala Ile Ile  Lys Leu Lys Glu Ile  Thr Ser Asp 
    1250                 1255                 1260             


Leu Leu  Ile Lys Tyr Glu Arg  Glu Ala Tyr Leu Ser  Met Lys Lys 
    1265                 1270                 1275             


Tyr Gly  Tyr Leu Gly Glu Val  Ile Ala Ala Arg Leu  Ser Pro Lys 
    1280                 1285                 1290             


Asp Lys  Ile Met Asn Tyr Val  His Glu Thr Asn Glu  Asp Ile Met 
    1295                 1300                 1305             


Ser Asn  Leu Arg Arg Tyr Asp  Met Glu Asn Ala Phe  Lys Asn Lys 
    1310                 1315                 1320             


Met Ser  Thr Tyr Val Asp Asp  Phe Ala Phe Phe Asp  Asp Cys Gly 
    1325                 1330                 1335             


Lys Asn  Glu Gln Phe Leu Asn  Glu Arg Cys Asp Tyr  Cys Pro Val 
    1340                 1345                 1350             


Ile Glu  Glu Val Glu Glu Thr  Gln Leu Phe Thr Thr  Thr Gly Asp 
    1355                 1360                 1365             


Lys Asn  Thr Asn Lys Thr Thr  Glu Ile Lys Lys Gln  Thr Ser Thr 
    1370                 1375                 1380             


Tyr Ile  Asp Thr Glu Lys Met  Asn Glu Ala Asp Ser  Ala Asp Ser 
    1385                 1390                 1395             


Asp Asp  Glu Lys Asp Ser Asp  Thr Pro Asp Asp Glu  Leu Met Ile 
    1400                 1405                 1410             


Ser Arg  Phe His 
    1415         


<210>  3
<211>  4251
<212>  DNA
<213>  Plasmodium falciparum

<400>  3
atggtttcat tttttaagac tccgatcatt attttttttt tcctcttatg tttaaatgaa       60

aaggtattat gttcaataaa tgaaaatgaa aatttaggcg aaaataaaaa cgaaaatgca      120

aatgtaaaca cacctgaaaa tttaaataaa cttctaaatg agtatgacaa tattgaacaa      180

ttaaaatcca tgataggaaa tgatgaacta cataagaatt taacaatatt agaaaaatta      240

attttagagt ctctagaaaa agataaatta aaatatcctc tccttaaaca aggaactgaa      300

caattgatag atatatcaaa atttaataaa aaaaatatta cagatgcgga tgatgaaacg      360

tacatcatac ctaccgtcca atcaagcttt cacgatattg taaaatatga acatcttata      420

aaagaacaat caatagaaat ttataattct gatatatcag ataaaattaa gaaaaaaata      480

tttattgtaa gaacattgaa aacaataaaa ttaatgctta taccattaaa ttcatacaaa      540

caaaataatg atttgaaatc tgcgctcgaa gaattaaata atgtatttac aaacaaagaa      600

gctcaaaagg aaagcagtcc aataggcgac catgggacat tctttagaaa attgttaaca      660

catgttagaa caattaaaga aaatgaagat atagaaaata aaggagaaac acttatatta      720

ggcgataata aaatagatgt aatgaattca aacgatttct tttttacaac caactcaaat      780

gtaaaattta tggaaaattt agatgatata acaaatcaat atggattagg tttgattaat      840

catttgggtc ctcatttaat agccttggga cattttgttg tattaaaatt agcactaaaa      900

aattacaaaa attattttga agcaaaaaat ataaaatttt ttagttggca aaaaatttta      960

gagttctcca tgtctgatag atttaaggtt cttgatatga tgtgtaacca tgaatctgta     1020

tattattccg aaaaaaaacg tagaaagaca tatttaaaag tcgacagatc aagcacatct     1080

atggaatgta atatattgga atatttatta cattatttta ataaatacca actagaaata     1140

attaaaacta cacaagatac agatttcgat ttacatggta tgatggaaca taaatatata     1200

aaagattatt tcttttcatt tatgtgtaac gatcctaaag aatgtattat ttatcatacg     1260

aatcaattta aaaaagaagc taacgaagaa aacacttttc ctgaacaaga agaacctaac     1320

cgtcaaataa gtgcatttaa tttatattta aattattatt atttcatgaa acgttatagt     1380

tcatatggaa caaaaaaaac attatatgtt catttattaa atttaactgg acttttaaac     1440

catgatacaa gagcatacgt gacatccctt tatttaccag gatattacaa cgctgtcgaa     1500

atgtctttta cggacgataa agagttttcc acactttttg aaagcttaat acaatgtatt     1560

gaaaaatgcc attcagacca agcaaggcaa atatcaaaag atagtaattt acttaataat     1620

ataacaaaat gtgatttgtg taaaggagcc tttttatatg ctaatatgaa attcgatgaa     1680

gttccttcaa tgttgcaaaa attttacgta tatttaacta aaggtctcaa aatacaaaaa     1740

gtatcatcac taatcaaaac gctagatata tatcaagatt acagtaattt cttatcacat     1800

gatattaatt ggtacacatt cctattttta tttagactta caagttttaa agaaattgca     1860

aataaaaatg ttgctgaagc aatgtattta aatataaaag atgaagacac attcaacaaa     1920

acgatagtaa caaactattg gtacccatct cctataaaaa aatattatac attatatgtt     1980

agaaaacata taccaaataa tttagtagat gaattagaga aattaatgaa aagtggcact     2040

ttagaaaaaa tgaaaaaatc tctcaccttt ttagtacatg tgaattcatt tttacaatta     2100

gattttttcc atcaattaaa tgaaccacct cttggattac ctcgatcata tccattatcg     2160

ttagttctcg aacataaatt taaagaatgg atggacagtt cgccagcagg tttctatttt     2220

tcaaattatc aaaatccata tatcagaaaa gatttgcatg ataaagtttt atcacaaaaa     2280

tttgaaccac ctaaaatgaa tcagtggaac aaagttttga aatcattaat tgaatgcgca     2340

tatgatatgt attttgaaca gagacatgtt aaaaatttat ataaatatca taacatttat     2400

aatataaata acaaattaat gttaatgcga gattcaatcg atttgtataa aaacaatttt     2460

gacgatgtgt tattttttgc ggatatattt aatatgagaa aatatatgac agctacacca     2520

gtatataaaa aagtaaaaga ccgagtgtac catacattgc atagtattac aggaaattct     2580

gtcaattttt ataaatatgg tattatatat ggatttaaag taaacaaaga aatattaaaa     2640

gaagttgtcg atgaattgta ttccatctat aattttaaca ccgacatatt tacggatact     2700

tcctttttac aaaccgttta tttattattt agaagaatag aagaaaccta taggacccaa     2760

agaagagatg ataaaattag tgtgaataac gtttttttca tgaatgttgc taataattat     2820

tccaaattaa acaaagaaga aagagaaatc gaaatacata attccatggc atcaagatat     2880

tatgcaaaaa cgatgtttgc agcatttcaa atgttatttt caacaatgtt gagcaacaat     2940

gtagataatc ttgataaagc atatggatta agtgaaaata tccaagtagc aacaagtact     3000

tccgcttttc ttacttttgc atatgtatat aacggaagta taatggatag tgtgactaac     3060

agtttattgc caccatatgc gaagaaacct ataacacaat taaaatatgg aaaaaccttc     3120

gttttctcaa actatttcat gctagcatcc aaaatgtatg atatgttaaa ttataaaaat     3180

ttaagtcttt tatgtgaata tcaggctgtg gcaagtgcca atttctactc tgctaaaaag     3240

gtaggtcagt ttcttggaag aaaattttta cccataacta catattttct agtaatgaga     3300

attagttgga cacatgcttt tacaactgga caacatttga tttgcgcttt tgatcccaaa     3360

agatgtactc ctgattgtaa aaatagtact agttataaat ctcctcaaag ttttttttac     3420

ggttggcctc ctagttcaga aacatatttg ttcttttatt ttttcacaaa tttatacctt     3480

gatgcctata aatcttttcc tggaggattt ggtcctgcaa taaaagaaca aactcaacat     3540

gttcaagaac aaacctacga acgcaaaccg tcagttcata gttttaatag aaattttttc     3600

atggaactcg taaatggatt catgtatgcc ttttgttttt ttgcaatttc tcaaatgtat     3660

gcatattttg aaaatattaa tttttatatt acaagtaatt tccgtttctt ggatagatat     3720

tatggtgtat tcaataaata ttttataaac tatgccataa ttaaacttaa agaaattact     3780

agtgatcttt taataaaata tgaacgtgag gcttatttaa gtatgaaaaa atatggttat     3840

ttaggtgaag ttattgcagc tagactttct ccaaaagata aaattatgaa ttatgtgcac     3900

gaaactaacg aagatatcat gagtaattta agaagatatg atatggaaaa tgctttcaaa     3960

aacaaaatgg ttacttatgt ggatgacttt gctttttttg atgattgtgg caaaaatgaa     4020

caatttttaa atgaaagatg tgattattgc cctgtaattg aagaggtgga agaaacacaa     4080

ttatttacta ccactggtga taaaaatact aatgagacca cggaaataaa aaaacaaact     4140

agtacatata ttgatactga aaaaatgaat gaagcggatt ctgctgatag cgacgatgaa     4200

aaggattttg atactcctga caatgaatta atgatcgcac gatttcatta a              4251


<210>  4
<211>  1416
<212>  PRT
<213>  Plasmodium falciparum

<400>  4

Met Val Ser Phe Phe Lys Thr Pro Ile Ile Ile Phe Phe Phe Leu Leu 
1               5                   10                  15      


Cys Leu Asn Glu Lys Val Leu Cys Ser Ile Asn Glu Asn Glu Asn Leu 
            20                  25                  30          


Gly Glu Asn Lys Asn Glu Asn Ala Asn Val Asn Thr Pro Glu Asn Leu 
        35                  40                  45              


Asn Lys Leu Leu Asn Glu Tyr Asp Asn Ile Glu Gln Leu Lys Ser Met 
    50                  55                  60                  


Ile Gly Asn Asp Glu Leu His Lys Asn Leu Thr Ile Leu Glu Lys Leu 
65                  70                  75                  80  


Ile Leu Glu Ser Leu Glu Lys Asp Lys Leu Lys Tyr Pro Leu Leu Lys 
                85                  90                  95      


Gln Gly Thr Glu Gln Leu Ile Asp Ile Ser Lys Phe Asn Lys Lys Asn 
            100                 105                 110         


Ile Thr Asp Ala Asp Asp Glu Thr Tyr Ile Ile Pro Thr Val Gln Ser 
        115                 120                 125             


Ser Phe His Asp Ile Val Lys Tyr Glu His Leu Ile Lys Glu Gln Ser 
    130                 135                 140                 


Ile Glu Ile Tyr Asn Ser Asp Ile Ser Asp Lys Ile Lys Lys Lys Ile 
145                 150                 155                 160 


Phe Ile Val Arg Thr Leu Lys Thr Ile Lys Leu Met Leu Ile Pro Leu 
                165                 170                 175     


Asn Ser Tyr Lys Gln Asn Asn Asp Leu Lys Ser Ala Leu Glu Glu Leu 
            180                 185                 190         


Asn Asn Val Phe Thr Asn Lys Glu Ala Gln Lys Glu Ser Ser Pro Ile 
        195                 200                 205             


Gly Asp His Gly Thr Phe Phe Arg Lys Leu Leu Thr His Val Arg Thr 
    210                 215                 220                 


Ile Lys Glu Asn Glu Asp Ile Glu Asn Lys Gly Glu Thr Leu Ile Leu 
225                 230                 235                 240 


Gly Asp Asn Lys Ile Asp Val Met Asn Ser Asn Asp Phe Phe Phe Thr 
                245                 250                 255     


Thr Asn Ser Asn Val Lys Phe Met Glu Asn Leu Asp Asp Ile Thr Asn 
            260                 265                 270         


Gln Tyr Gly Leu Gly Leu Ile Asn His Leu Gly Pro His Leu Ile Ala 
        275                 280                 285             


Leu Gly His Phe Val Val Leu Lys Leu Ala Leu Lys Asn Tyr Lys Asn 
    290                 295                 300                 


Tyr Phe Glu Ala Lys Asn Ile Lys Phe Phe Ser Trp Gln Lys Ile Leu 
305                 310                 315                 320 


Glu Phe Ser Met Ser Asp Arg Phe Lys Val Leu Asp Met Met Cys Asn 
                325                 330                 335     


His Glu Ser Val Tyr Tyr Ser Glu Lys Lys Arg Arg Lys Thr Tyr Leu 
            340                 345                 350         


Lys Val Asp Arg Ser Ser Thr Ser Met Glu Cys Asn Ile Leu Glu Tyr 
        355                 360                 365             


Leu Leu His Tyr Phe Asn Lys Tyr Gln Leu Glu Ile Ile Lys Thr Thr 
    370                 375                 380                 


Gln Asp Thr Asp Phe Asp Leu His Gly Met Met Glu His Lys Tyr Ile 
385                 390                 395                 400 


Lys Asp Tyr Phe Phe Ser Phe Met Cys Asn Asp Pro Lys Glu Cys Ile 
                405                 410                 415     


Ile Tyr His Thr Asn Gln Phe Lys Lys Glu Ala Asn Glu Glu Asn Thr 
            420                 425                 430         


Phe Pro Glu Gln Glu Glu Pro Asn Arg Gln Ile Ser Ala Phe Asn Leu 
        435                 440                 445             


Tyr Leu Asn Tyr Tyr Tyr Phe Met Lys Arg Tyr Ser Ser Tyr Gly Thr 
    450                 455                 460                 


Lys Lys Thr Leu Tyr Val His Leu Leu Asn Leu Thr Gly Leu Leu Asn 
465                 470                 475                 480 


His Asp Thr Arg Ala Tyr Val Thr Ser Leu Tyr Leu Pro Gly Tyr Tyr 
                485                 490                 495     


Asn Ala Val Glu Met Ser Phe Thr Asp Asp Lys Glu Phe Ser Thr Leu 
            500                 505                 510         


Phe Glu Ser Leu Ile Gln Cys Ile Glu Lys Cys His Ser Asp Gln Ala 
        515                 520                 525             


Arg Gln Ile Ser Lys Asp Ser Asn Leu Leu Asn Asn Ile Thr Lys Cys 
    530                 535                 540                 


Asp Leu Cys Lys Gly Ala Phe Leu Tyr Ala Asn Met Lys Phe Asp Glu 
545                 550                 555                 560 


Val Pro Ser Met Leu Gln Lys Phe Tyr Val Tyr Leu Thr Lys Gly Leu 
                565                 570                 575     


Lys Ile Gln Lys Val Ser Ser Leu Ile Lys Thr Leu Asp Ile Tyr Gln 
            580                 585                 590         


Asp Tyr Ser Asn Phe Leu Ser His Asp Ile Asn Trp Tyr Thr Phe Leu 
        595                 600                 605             


Phe Leu Phe Arg Leu Thr Ser Phe Lys Glu Ile Ala Asn Lys Asn Val 
    610                 615                 620                 


Ala Glu Ala Met Tyr Leu Asn Ile Lys Asp Glu Asp Thr Phe Asn Lys 
625                 630                 635                 640 


Thr Ile Val Thr Asn Tyr Trp Tyr Pro Ser Pro Ile Lys Lys Tyr Tyr 
                645                 650                 655     


Thr Leu Tyr Val Arg Lys His Ile Pro Asn Asn Leu Val Asp Glu Leu 
            660                 665                 670         


Glu Lys Leu Met Lys Ser Gly Thr Leu Glu Lys Met Lys Lys Ser Leu 
        675                 680                 685             


Thr Phe Leu Val His Val Asn Ser Phe Leu Gln Leu Asp Phe Phe His 
    690                 695                 700                 


Gln Leu Asn Glu Pro Pro Leu Gly Leu Pro Arg Ser Tyr Pro Leu Ser 
705                 710                 715                 720 


Leu Val Leu Glu His Lys Phe Lys Glu Trp Met Asp Ser Ser Pro Ala 
                725                 730                 735     


Gly Phe Tyr Phe Ser Asn Tyr Gln Asn Pro Tyr Ile Arg Lys Asp Leu 
            740                 745                 750         


His Asp Lys Val Leu Ser Gln Lys Phe Glu Pro Pro Lys Met Asn Gln 
        755                 760                 765             


Trp Asn Lys Val Leu Lys Ser Leu Ile Glu Cys Ala Tyr Asp Met Tyr 
    770                 775                 780                 


Phe Glu Gln Arg His Val Lys Asn Leu Tyr Lys Tyr His Asn Ile Tyr 
785                 790                 795                 800 


Asn Ile Asn Asn Lys Leu Met Leu Met Arg Asp Ser Ile Asp Leu Tyr 
                805                 810                 815     


Lys Asn Asn Phe Asp Asp Val Leu Phe Phe Ala Asp Ile Phe Asn Met 
            820                 825                 830         


Arg Lys Tyr Met Thr Ala Thr Pro Val Tyr Lys Lys Val Lys Asp Arg 
        835                 840                 845             


Val Tyr His Thr Leu His Ser Ile Thr Gly Asn Ser Val Asn Phe Tyr 
    850                 855                 860                 


Lys Tyr Gly Ile Ile Tyr Gly Phe Lys Val Asn Lys Glu Ile Leu Lys 
865                 870                 875                 880 


Glu Val Val Asp Glu Leu Tyr Ser Ile Tyr Asn Phe Asn Thr Asp Ile 
                885                 890                 895     


Phe Thr Asp Thr Ser Phe Leu Gln Thr Val Tyr Leu Leu Phe Arg Arg 
            900                 905                 910         


Ile Glu Glu Thr Tyr Arg Thr Gln Arg Arg Asp Asp Lys Ile Ser Val 
        915                 920                 925             


Asn Asn Val Phe Phe Met Asn Val Ala Asn Asn Tyr Ser Lys Leu Asn 
    930                 935                 940                 


Lys Glu Glu Arg Glu Ile Glu Ile His Asn Ser Met Ala Ser Arg Tyr 
945                 950                 955                 960 


Tyr Ala Lys Thr Met Phe Ala Ala Phe Gln Met Leu Phe Ser Thr Met 
                965                 970                 975     


Leu Ser Asn Asn Val Asp Asn Leu Asp Lys Ala Tyr Gly Leu Ser Glu 
            980                 985                 990         


Asn Ile Gln Val Ala Thr Ser Thr  Ser Ala Phe Leu Thr  Phe Ala Tyr 
        995                 1000                 1005             


Val Tyr  Asn Gly Ser Ile Met  Asp Ser Val Thr Asn  Ser Leu Leu 
    1010                 1015                 1020             


Pro Pro  Tyr Ala Lys Lys Pro  Ile Thr Gln Leu Lys  Tyr Gly Lys 
    1025                 1030                 1035             


Thr Phe  Val Phe Ser Asn Tyr  Phe Met Leu Ala Ser  Lys Met Tyr 
    1040                 1045                 1050             


Asp Met  Leu Asn Tyr Lys Asn  Leu Ser Leu Leu Cys  Glu Tyr Gln 
    1055                 1060                 1065             


Ala Val  Ala Ser Ala Asn Phe  Tyr Ser Ala Lys Lys  Val Gly Gln 
    1070                 1075                 1080             


Phe Leu  Gly Arg Lys Phe Leu  Pro Ile Thr Thr Tyr  Phe Leu Val 
    1085                 1090                 1095             


Met Arg  Ile Ser Trp Thr His  Ala Phe Thr Thr Gly  Gln His Leu 
    1100                 1105                 1110             


Ile Cys  Ala Phe Asp Pro Lys  Arg Cys Thr Pro Asp  Cys Lys Asn 
    1115                 1120                 1125             


Ser Thr  Ser Tyr Lys Ser Pro  Gln Ser Phe Phe Tyr  Gly Trp Pro 
    1130                 1135                 1140             


Pro Ser  Ser Glu Thr Tyr Leu  Phe Phe Tyr Phe Phe  Thr Asn Leu 
    1145                 1150                 1155             


Tyr Leu  Asp Ala Tyr Lys Ser  Phe Pro Gly Gly Phe  Gly Pro Ala 
    1160                 1165                 1170             


Ile Lys  Glu Gln Thr Gln His  Val Gln Glu Gln Thr  Tyr Glu Arg 
    1175                 1180                 1185             


Lys Pro  Ser Val His Ser Phe  Asn Arg Asn Phe Phe  Met Glu Leu 
    1190                 1195                 1200             


Val Asn  Gly Phe Met Tyr Ala  Phe Cys Phe Phe Ala  Ile Ser Gln 
    1205                 1210                 1215             


Met Tyr  Ala Tyr Phe Glu Asn  Ile Asn Phe Tyr Ile  Thr Ser Asn 
    1220                 1225                 1230             


Phe Arg  Phe Leu Asp Arg Tyr  Tyr Gly Val Phe Asn  Lys Tyr Phe 
    1235                 1240                 1245             


Ile Asn  Tyr Ala Ile Ile Lys  Leu Lys Glu Ile Thr  Ser Asp Leu 
    1250                 1255                 1260             


Leu Ile  Lys Tyr Glu Arg Glu  Ala Tyr Leu Ser Met  Lys Lys Tyr 
    1265                 1270                 1275             


Gly Tyr  Leu Gly Glu Val Ile  Ala Ala Arg Leu Ser  Pro Lys Asp 
    1280                 1285                 1290             


Lys Ile  Met Asn Tyr Val His  Glu Thr Asn Glu Asp  Ile Met Ser 
    1295                 1300                 1305             


Asn Leu  Arg Arg Tyr Asp Met  Glu Asn Ala Phe Lys  Asn Lys Met 
    1310                 1315                 1320             


Val Thr  Tyr Val Asp Asp Phe  Ala Phe Phe Asp Asp  Cys Gly Lys 
    1325                 1330                 1335             


Asn Glu  Gln Phe Leu Asn Glu  Arg Cys Asp Tyr Cys  Pro Val Ile 
    1340                 1345                 1350             


Glu Glu  Val Glu Glu Thr Gln  Leu Phe Thr Thr Thr  Gly Asp Lys 
    1355                 1360                 1365             


Asn Thr  Asn Glu Thr Thr Glu  Ile Lys Lys Gln Thr  Ser Thr Tyr 
    1370                 1375                 1380             


Ile Asp  Thr Glu Lys Met Asn  Glu Ala Asp Ser Ala  Asp Ser Asp 
    1385                 1390                 1395             


Asp Glu  Lys Asp Phe Asp Thr  Pro Asp Asn Glu Leu  Met Ile Ala 
    1400                 1405                 1410             


Arg Phe  His 
    1415     


<210>  5
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
ataccgtcga cttgtcaatt tttatgtttg cataaacg                               38


<210>  6
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
aattaggtac cgtacaaata aatacaatat ttttcatagc aa                          42


<210>  7
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
tatccgtcga ctctatttac actcatgaag acagaggtaa                             40


<210>  8
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
aattaggtac ccttcattga aaattttaca agggtatc                               38


<210>  9
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ataccgtcga ctatgaatga ttgtactact tttgtaagaa t                           41


<210>  10
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
aatatggtac ctacacattg acatagggta tcatcatt                               38


<210>  11
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
ataccgtcga ccctttttac acgtatattc ggacaatc                               38


<210>  12
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
aattaggtac cgttaacacg aacaattttg cagtatg                                37


<210>  13
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
ataccgtcga ccaaaaaacc gaaatggcat ttc                                    33


<210>  14
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
aattaggtac catgaaatat gtaatacgtg ggttaaaag                              39


<210>  15
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
ataccgtcga cttccatgtt taaagtgaaa ttagaagata t                           41


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
aattaggtac ccgacattat gttatttcgg cga                                    33


<210>  17
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
ataccgtcga ccagtatata taatcaaatt gagcttaaaa ag                          42


<210>  18
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
aattaggtac cagtgtttta aggcaataat tatattgtat t                           41


<210>  19
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
tcgacctcga gcataaaatt gtgtgtttca ttaaaatcat                             40


<210>  20
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
acgtagggcc catgtataaa tgaaaaatga atgtgactct t                           41


<210>  21
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
attcagtcga caagaaaaag gtaatatttt agtacactca a                           41


<210>  22
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
tattcggtac ctttgtaata tacctttatg cgttgaca                               38


<210>  23
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
atgcagtcga catgcactca ttaataattt taaaccgt                               38


<210>  24
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
tcgatgggcc ccttttcaat taattttata ttcttttgtt c                           41


<210>  25
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
ataccgtcga ccctgacgat gaattaatga tatcacg                                37


<210>  26
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
tataaggtac ccaggttaat atagccaaaa taaattgaaa                             40


<210>  27
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
atagagtcga cggatattag ctgataaagc agcagc                                 36


<210>  28
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
gatttggtac ctttgttttc atgtcccatc ataattc                                37


<210>  29
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
ataccgtcga ctattctact taaagatgaa tagcacatat g                           41


<210>  30
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
acattgggcc cttcccctca catatcaatc ataaat                                 36


<210>  31
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
atacagtcga cgcatcctat tcccatcctt tcct                                   34


<210>  32
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
actgagggcc cgacaagaag cattacagag agcaa                                  35


<210>  33
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
ataccgtcga cattttgccc aagaatataa aataataaga t                           41


<210>  34
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
aattaggtac ccagagaaag aaaaatgtca atataaataa a                           41


<210>  35
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
cataagcggc cgcgccattc agaccaagca agg                                    33


<210>  36
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ttaaactgca gcttttcaat taattttata ttcttttgtt c                           41


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Phe Leu Asn Cys Cys Pro Cys Cys Met Glu Pro Gly Ser Asp Tyr Lys 
1               5                   10                  15      


Asp Asp Asp Asp Lys 
            20      


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
gtggaattgt gagcggataa ca                                                22


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
tcatcgtcct tatagtcgga tcc                                               23


<210>  40
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
atgttttgta atttatggga tagcga                                            26


<210>  41
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
gttgagtacg cactaatatg tcaatttg                                          28


<210>  42
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
aaccataaca ttatcatata tgttaattac ac                                     32


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
atttccagag aatgaccaca ac                                                22


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
ttaagatggc ctgggtgatt c                                                 21


<210>  45
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
ctcttactac ttattatcta tctctca                                           27


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
ccaggcgtag gtcctttac                                                    19


<210>  47
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
acccataact acatattttc tagtaatg                                          28


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gacaagttcc agaagcatcc t                                                 21


<210>  49
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
acccataact acatattttc tagtaatg                                          28


<210>  50
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
agatttagtt acacttgaag aattagtatt                                        30


<210>  51
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
acccataact acatattttc tagtaatg                                          28


<210>  52
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
gatttataac taggagcact acattta                                           27


<210>  53
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
acccataact acatattttc tagtaatg                                          28


<210>  54
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
ttataaccat taggagcact actttc                                            26


<210>  55
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
acccataact acatattttc tagtaatg                                          28


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
gacaagttcc agaagcatcc t                                                 21


<210>  57
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
gttactacaa cattcctgat tcag                                              24


<210>  58
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
aatgaaaata taaaaatgct gggggat                                           27


<210>  59
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
taccattagt gttttataca cttaagg                                           27


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
ccaaaatatg gccaagtact tgc                                               23


<210>  61
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Met Gly Ser Ser His His His His His His Ser Ser Gly Gly Thr Lys 
1               5                   10                  15      


Lys Tyr Gly Tyr Leu Gly Glu Val Ile Ala Ala Arg Leu Ser Pro Lys 
            20                  25                  30          


Asp Lys Ile Met Asn Tyr Val His Glu Thr Asn Glu Asp Ile Met Ser 
        35                  40                  45              


Asn Leu Arg Arg Tyr Asp Met Glu Asn Ala Phe Lys Asn Lys Met Ser 
    50                  55                  60                  


Thr Tyr Val Asp Asp Phe Ala Phe Phe Asp Asp Cys Gly Lys Asn Glu 
65                  70                  75                  80  


Gln Phe Leu Asn Glu Arg Cys Asp Tyr Cys Pro Val Ile Glu Glu Val 
                85                  90                  95      


Glu Glu Thr Gln Leu Phe Thr Thr Thr Gly Asp Lys Asn Thr Asn Lys 
            100                 105                 110         


Thr Thr Glu Ile Lys Lys Gln Thr Ser Thr Tyr Ile Asp Thr Glu Lys 
        115                 120                 125             


Met Asn Glu Ala Asp Ser Ala Asp Ser Asp Asp Glu Lys Asp Ser Asp 
    130                 135                 140                 


Thr Pro Asp Asp Glu Leu Met Ile Ser Arg Phe His Asp Tyr Lys Asp 
145                 150                 155                 160 


Asp Asp Asp Lys 
                


<210>  62
<211>  146
<212>  PRT
<213>  Plasmodium falciparum

<400>  62

Cys Glu Tyr Gln Ala Val Ala Ser Ala Asn Phe Tyr Ser Ala Lys Lys 
1               5                   10                  15      


Val Gly Gln Phe Leu Gly Arg Lys Phe Leu Pro Ile Thr Thr Tyr Phe 
            20                  25                  30          


Leu Val Met Arg Ile Ser Trp Thr His Ala Phe Thr Thr Gly Gln His 
        35                  40                  45              


Leu Ile Ser Ala Phe Gly Ser Pro Ser Ser Thr Ala Asn Gly Lys Ser 
    50                  55                  60                  


Asn Ala Ser Gly Tyr Lys Ser Pro Glu Ser Phe Phe Phe Thr His Gly 
65                  70                  75                  80  


Leu Ala Ala Glu Ala Ser Lys Tyr Leu Phe Phe Tyr Phe Phe Thr Asn 
                85                  90                  95      


Leu Tyr Leu Asp Ala Tyr Lys Ser Phe Pro Gly Gly Phe Gly Pro Ala 
            100                 105                 110         


Ile Lys Glu Gln Thr Gln His Val Gln Glu Gln Thr Tyr Glu Arg Lys 
        115                 120                 125             


Pro Ser Val His Ser Phe Asn Arg Asn Phe Phe Met Glu Leu Val Asn 
    130                 135                 140                 


Gly Phe 
145     


<210>  63
<211>  438
<212>  DNA
<213>  Plasmodium falciparum

<400>  63
tgtgaatatc aggctgtggc aagtgccaat ttctactctg ctaaaaaggt aggtcagttt       60

cttggaagaa aatttttacc cataactaca tattttctag taatgagaat tagttggaca      120

catgctttta caactggaca acatttgatt agcgcttttg gttccccaag ttctactgct      180

aatggtaaaa gtaatgctag tggttataaa tcccctgaaa gttttttctt cactcacgga      240

cttgctgctg aagcatccaa atatttattt ttttattttt tcacaaattt ataccttgat      300

gcctacaaat cttttcctgg aggatttggt cctgcaataa aagaacaaac tcaacatgtt      360

caagaacaaa cctacgaacg caaaccgtca gttcatagtt ttaatagaaa ttttttcatg      420

gaactcgtaa atggattc                                                    438


<210>  64
<211>  186
<212>  PRT
<213>  Plasmodium falciparum

<400>  64

Thr Ser Asn Phe Arg Phe Leu Asp Arg Tyr Tyr Gly Val Phe Asn Lys 
1               5                   10                  15      


Tyr Phe Ile Asn Tyr Ala Ile Ile Lys Leu Lys Glu Ile Thr Ser Asp 
            20                  25                  30          


Leu Leu Ile Lys Tyr Glu Arg Glu Ala Tyr Leu Ser Met Lys Lys Tyr 
        35                  40                  45              


Gly Tyr Leu Gly Glu Val Ile Ala Ala Arg Leu Ser Pro Lys Asp Lys 
    50                  55                  60                  


Ile Met Asn Tyr Val His Glu Thr Asn Glu Asp Ile Met Ser Asn Leu 
65                  70                  75                  80  


Arg Arg Tyr Asp Met Glu Asn Ala Phe Lys Asn Lys Met Ser Thr Tyr 
                85                  90                  95      


Val Asp Asp Phe Ala Phe Phe Asp Asp Cys Gly Lys Asn Glu Gln Phe 
            100                 105                 110         


Leu Asn Glu Arg Cys Asp Tyr Cys Pro Val Ile Glu Glu Val Glu Glu 
        115                 120                 125             


Thr Gln Leu Phe Thr Thr Thr Gly Asp Lys Asn Thr Asn Lys Thr Thr 
    130                 135                 140                 


Glu Ile Lys Lys Gln Thr Ser Thr Tyr Ile Asp Thr Glu Lys Met Asn 
145                 150                 155                 160 


Glu Ala Asp Ser Ala Asp Ser Asp Asp Glu Lys Asp Ser Asp Thr Pro 
                165                 170                 175     


Asp Asp Glu Leu Met Ile Ser Arg Phe His 
            180                 185     


<210>  65
<211>  558
<212>  DNA
<213>  Plasmodium falciparum

<400>  65
acaagtaatt tccgtttctt ggatagatat tatggtgtat tcaataaata ttttataaac       60

tatgccataa ttaaacttaa agaaattact agtgatcttt taataaaata tgaacgtgag      120

gcttatttaa gtatgaaaaa atatggttat ttaggtgaag ttattgcagc tagactttct      180

ccaaaagata aaattatgaa ttatgtgcac gaaactaacg aagatatcat gagtaattta      240

agaagatatg atatggaaaa tgctttcaaa aacaaaatgt caacatatgt agatgatttt      300

gctttttttg atgattgcgg aaaaaatgaa caatttttaa atgagagatg tgattattgt      360

cctgtaattg aagaggtcga agaaacacaa ttatttacta ccactggtga taaaaacact      420

aataagacca cggaaataaa aaaacaaact agtacatata ttgatactga aaaaatgaat      480

gaagcggatt ctgctgatag cgacgatgaa aaggattctg atactcctga cgatgaatta      540

atgatatcac gatttcac                                                    558


<210>  66
<211>  308
<212>  PRT
<213>  Plasmodium falciparum

<400>  66

Ser Ile Asn Glu Asn Gln Asn Glu Asn Asp Thr Ile Ser Gln Asn Val 
1               5                   10                  15      


Asn Gln His Glu Asn Ile Asn Gln Asn Val Asn Asp Asn Asp Asn Ile 
            20                  25                  30          


Glu Gln Leu Lys Ser Met Ile Gly Asn Asp Glu Leu His Lys Asn Leu 
        35                  40                  45              


Thr Ile Leu Glu Lys Leu Ile Leu Glu Ser Leu Glu Lys Asp Lys Leu 
    50                  55                  60                  


Lys Tyr Pro Leu Leu Lys Gln Gly Thr Glu Gln Leu Ile Asp Ile Ser 
65                  70                  75                  80  


Lys Phe Asn Lys Lys Asn Ile Thr Asp Ala Asp Asp Glu Thr Tyr Ile 
                85                  90                  95      


Ile Pro Thr Val Gln Ser Thr Phe His Asp Ile Val Lys Tyr Glu His 
            100                 105                 110         


Leu Ile Lys Glu Gln Ser Ile Glu Ile Tyr Asn Ser Asp Ile Ser Asp 
        115                 120                 125             


Lys Ile Lys Lys Lys Ile Phe Ile Val Arg Thr Leu Lys Thr Ile Lys 
    130                 135                 140                 


Leu Met Leu Ile Pro Leu Asn Ser Tyr Lys Gln Asn Asn Asp Leu Lys 
145                 150                 155                 160 


Ser Ala Leu Glu Glu Leu Asn Asn Val Phe Thr Asn Lys Glu Ala Gln 
                165                 170                 175     


Glu Glu Ser Ser Pro Ile Gly Asp His Gly Thr Phe Phe Arg Lys Leu 
            180                 185                 190         


Leu Thr His Val Arg Thr Ile Lys Glu Asn Glu Asp Ile Glu Asn Lys 
        195                 200                 205             


Gly Glu Thr Leu Ile Leu Gly Asp Asn Lys Ile Asp Val Met Asn Ser 
    210                 215                 220                 


Asn Asp Phe Phe Phe Thr Thr Asn Ser Asn Val Lys Phe Met Glu Asn 
225                 230                 235                 240 


Leu Asp Asp Ile Thr Asn Gln Tyr Gly Leu Gly Leu Ile Asn His Leu 
                245                 250                 255     


Gly Pro His Leu Ile Ala Leu Gly His Phe Thr Val Leu Lys Leu Ala 
            260                 265                 270         


Leu Lys Asn Tyr Lys Asn Tyr Phe Glu Ala Lys Ser Ile Lys Phe Phe 
        275                 280                 285             


Ser Trp Gln Lys Ile Leu Glu Phe Ser Met Ser Asp Arg Phe Lys Val 
    290                 295                 300                 


Leu Asp Met Met 
305             


<210>  67
<211>  924
<212>  DNA
<213>  Plasmodium falciparum

<400>  67
tcaataaatg aaaatcaaaa tgaaaatgat accattagtc aaaatgtcaa ccaacatgaa       60

aatattaatc aaaatgtaaa tgataatgac aatattgaac aattaaaatc catgattgga      120

aatgatgaac tacataagaa tttaacaata ttagaaaaat taattttaga gtctttagaa      180

aaagataaat taaaatatcc tctccttaaa caaggaactg aacaattgat agatatatca      240

aaatttaata aaaaaaatat tacagatgcg gatgatgaaa cgtacatcat acccaccgtc      300

caatcaacgt ttcacgatat tgtgaaatac gaacatctta taaaagaaca atcaatagaa      360

atttacaatt ctgatatatc agataaaatt aagaaaaaaa tttttatagt aagaacattg      420

aaaaccataa aattaatgct tataccatta aactcgtaca aacaaaataa tgacttgaaa      480

tctgcactcg aagaattaaa taatgtattt acaaacaaag aagctcaaga ggaaagcagt      540

ccaataggcg accatgggac attctttaga aaattgttaa cacatgttag aacaattaaa      600

gaaaatgaag atatagaaaa taaaggagaa acacttatat taggcgataa taaaatagat      660

gtaatgaatt caaacgattt cttttttaca accaactcaa atgtaaaatt tatggaaaat      720

ttagatgata taacaaatca atatggatta ggtttgatta atcatctagg tcctcattta      780

atagccttgg gtcattttac cgtattaaaa ttagcactaa aaaattacaa aaactatttt      840

gaagcaaaaa gtattaaatt ttttagttgg caaaaaattt tagagttctc catgtctgat      900

agatttaaag ttcttgatat gatg                                             924


<210>  68
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
gtgcaatata tcaaagtgta catgca                                            26


<210>  69
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
aagaaaataa atgcaaaaca agttaga                                           27


<210>  70
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
atttacaaac aaagaagctc aagagga                                           27


<210>  71
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
ttttctatat cttcattttc tttaattgtt c                                      31


<210>  72
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Cys Glu Tyr Gln Ala Val Ala Ser Ala Asn Phe Tyr Ser Ala Lys Lys 
1               5                   10                  15      


Val Gly Gln Phe Ile Gly Arg Lys Phe Leu Pro Ile Thr Thr Tyr Phe 
            20                  25                  30          


Leu Val Met Arg Ile Ser Trp Thr His Ala Ile Thr Thr Gly Gln His 
        35                  40                  45              


Leu Ile Pro Gln Leu Thr Asp Pro Glu Tyr Gly Gln Thr Pro Lys Gly 
    50                  55                  60                  


Lys Asp Ala Ser Gly Thr Cys Pro Ser Ala Gly Leu Glu Lys Cys Thr 
65                  70                  75                  80  


Asn Tyr Arg Ala Pro Gly Ser Phe Phe Phe Thr His Gly Leu Ala Ala 
                85                  90                  95      


Glu Ala Ser Lys Tyr Leu Phe Phe Tyr Phe Phe Thr Asn Leu Tyr Leu 
            100                 105                 110         


Asp Ala Tyr Lys Ser Phe Pro Gly Gly Phe Gly Pro Ala Ile Lys Glu 
        115                 120                 125             


Gln Thr Gln His Val Gln Glu Gln Thr Tyr Glu Arg Lys Pro Ser Val 
    130                 135                 140                 


His Ser Phe Asn Arg Asn Phe Phe Met Glu Leu Ala Asn Gly Phe Met 
145                 150                 155                 160 


Tyr Ala Phe Cys Phe Phe Ala Ile Ser Gln Met Tyr Ala Tyr Phe Glu 
                165                 170                 175     


Asn Ile Asn Phe Tyr Ile 
            180         


<210>  73
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
tgtgaatatc aggcggtagc aagtgcaaat ttctactctg ctaaaaaggt agggcaattt       60

attggaagaa aatttttacc cataactaca tattttctag taatgagaat tagttggaca      120

cacgctatta caactggaca acatttaatt ccccaattaa cagatcctga atacggtcaa      180

actcctaagg gaaaggatgc ttctggaact tgtcctagtg cgggtttaga aaaatgtact      240

aactatagag ctcctggaag ttttttcttt actcacggac ttgctgctga agcatccaaa      300

tatttatttt tttatttttt cacaaattta taccttgatg cctacaaatc ttttcctgga      360

ggatttggtc ctgcaataaa agaacaaact caacatgttc aagaacaaac ctacgaacgc      420

aaaccgtcag ttcatagttt taatagaaat tttttcatgg aacttgcaaa tggtttcatg      480

tatgcttttt gtttttttgc tatttcacaa atgtatgcat attttgaaaa tattaatttt      540

tatatt                                                                 546


<210>  74
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Leu Tyr Leu Pro Gly Tyr Tyr Asn Ala Val Glu Met Ser Phe Thr Glu 
1               5                   10                  15      


Glu Lys Glu Phe Ser Lys Leu Phe Glu Ser Leu Ile Gln Cys Ile Glu 
            20                  25                  30          


Lys Cys His Ser Asp Gln Ala Arg Gln Ile Ser Lys Asp Ser Asn Leu 
        35                  40                  45              


Leu Asn Asn Ile Thr Lys Cys Asp Leu Cys Lys Gly Ala Phe Leu Tyr 
    50                  55                  60                  


Ala Asn Met Lys Phe Asp Glu Val Pro Ser Met Leu Gln Lys Phe Tyr 
65                  70                  75                  80  


Val Tyr Leu Thr Lys Gly Leu Lys Ile Gln Lys Val Ser Ser Leu Ile 
                85                  90                  95      


Lys Thr Leu Asp Ile Tyr Gln Asp Tyr Ser Asn Tyr Leu Ser His Asp 
            100                 105                 110         


Ile Asn Trp Tyr Thr Phe Leu Phe Leu Phe Arg Leu Thr Ser Phe Lys 
        115                 120                 125             


Glu Ile Ala Lys Lys Asn Val Ala Glu Ala Met Tyr Leu Asn Ile Lys 
    130                 135                 140                 


Asp Glu Asp Thr Phe Asn Lys Thr Val Val Thr Asn Tyr Trp Tyr Pro 
145                 150                 155                 160 


Ser Pro Ile Lys Lys Tyr Tyr Thr Leu Tyr Val Arg Lys His Ile Pro 
                165                 170                 175     


Asn Asn Leu Val Asp Glu Leu Glu Lys Leu Met Lys Ser Gly Thr Leu 
            180                 185                 190         


Glu Lys Met Lys Lys Ser Leu Thr Phe Leu Val His Val Asn Ser Phe 
        195                 200                 205             


Leu Gln Leu Asp Phe Phe His Gln Leu Asn Glu Pro Pro Leu Gly Leu 
    210                 215                 220                 


Pro Arg Ser Tyr Pro Leu Ser Leu Val Leu Glu His Lys Phe Lys Glu 
225                 230                 235                 240 


Trp Met Asn Ser Ser Pro Ala Gly Phe Tyr Phe Ser Asn Tyr Gln Asn 
                245                 250                 255     


Pro Tyr Ile Arg Lys Asp Leu His Asp Lys Val Leu Ser Gln Lys Phe 
            260                 265                 270         


Glu Pro Pro Lys Met Asn Gln Trp Asn Lys Val Leu Lys Ser Leu Ile 
        275                 280                 285             


Glu Cys Ala Tyr Asp Met Tyr Phe Glu Gln Arg His Val Lys Asn Leu 
    290                 295                 300                 


Tyr Lys Tyr His Asn Ile Tyr Asn Ile Asn Asn Lys Leu Met Leu Met 
305                 310                 315                 320 


Arg Asp Ser Ile Asp Leu Tyr Lys Asn Asn Phe Asp Asp Val Leu Phe 
                325                 330                 335     


Phe Ala Asp Ile Phe Asn Met Arg Lys Tyr Met Thr Ala Thr Pro Val 
            340                 345                 350         


Tyr Lys Lys Val Lys Asp Arg Val Tyr His Thr Leu His Ser Ile Thr 
        355                 360                 365             


Gly Asn Ser Val Asn Phe Tyr Lys Tyr Gly Ile Ile Tyr Gly Phe Lys 
    370                 375                 380                 


Val Asn Lys Glu Ile Leu Lys Glu Val Val Asp Glu Leu Tyr Ser Ile 
385                 390                 395                 400 


Tyr Asn Phe Asn Thr Asp Ile Phe Thr Asp Thr Ser Phe Leu Gln Thr 
                405                 410                 415     


Val Tyr Leu Leu 
            420 


<210>  75
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
ctttatttac caggatatta caacgctgtc gaaatgtctt ttacggaaga aaaagagttt       60

tccaaacttt ttgaaagctt aatacaatgt attgaaaaat gccattcaga ccaagcaagg      120

caaatatcaa aagatagtaa tttacttaat aatataacaa aatgtgattt gtgtaaagga      180

gcctttttat atgctaatat gaaattcgat gaagttcctt caatgttgca aaaattttac      240

gtatatttaa ctaaaggtct caaaatacaa aaagtatcat cactaatcaa aacgctagat      300

atatatcaag attacagcaa ttacttatca catgatatta attggtacac attcctattt      360

ttatttagac ttacaagttt taaagaaatt gcaaagaaaa atgttgctga agcaatgtat      420

ttaaatataa aagatgaaga cacattcaac aaaacggtag taacaaacta ttggtaccca      480

tctcctataa aaaaatatta tacattatat gttagaaaac atataccaaa taatttagta      540

gatgaattgg agaaattaat gaaaagtggc actttagaaa aaatgaaaaa atctctcacc      600

tttttagtac atgtgaattc atttttacaa ttagattttt tccatcaatt aaatgaacca      660

cctcttggat tacctcgatc atatccatta tcgttagttc tcgaacataa atttaaagaa      720

tggatgaaca gttcgccagc aggtttctat ttttcaaatt atcaaaatcc atatatcaga      780

aaagatttgc atgataaagt tttatcacaa aaatttgaac cacctaaaat gaatcagtgg      840

aacaaagttt tgaaatcatt aattgaatgc gcatatgata tgtattttga acagagacat      900

gttaaaaatt tatataaata tcataacatt tataatataa ataacaaatt aatgttaatg      960

cgagattcaa tcgatttgta taaaaacaat tttgacgatg tgttattttt tgcggatata     1020

tttaatatga gaaaatatat gacagctaca ccagtatata aaaaagtaaa agacagagtg     1080

taccatacat tgcatagtat tacaggaaat tctgtcaatt tttataaata tggtattata     1140

tatggattta aagtaaacaa agaaatatta aaagaagttg tcgatgaatt gtattccatc     1200

tataatttta acaccgacat atttacggat acttcctttt tacaaaccgt ttatttatta     1260


<210>  76
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Ser Val Asn Asn Val Phe Phe Met Asn Val Ala Asn Asn Tyr Ser Lys 
1               5                   10                  15      


Leu Asn Lys Glu Glu Arg Glu Ile Glu Ile His Asn Ser Met Ala Ser 
            20                  25                  30          


Arg Tyr Tyr Ala Lys Thr Met Phe Ala Ala Phe Gln Met Leu Phe Ser 
        35                  40                  45              


Thr Met Leu Ser Asn Asn Val Asp Asn Leu Asp Lys Ala Tyr Gly Leu 
    50                  55                  60                  


Ser Glu Asn Ile Gln Val Ala Thr Ser Thr Ser Ala Phe Leu Thr Phe 
65                  70                  75                  80  


Ala Tyr Val Tyr Asn Gly Ser Ile Met Asp Ser Val Thr Asn Ser Leu 
                85                  90                  95      


Leu Pro Pro Tyr Ala Lys Lys Pro Ile Thr Gln Leu Lys Tyr Gly Lys 
            100                 105                 110         


Thr Phe Val Phe Ser Asn Tyr Phe 
        115                 120 


<210>  77
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
agtgtgaata acgttttttt catgaatgtt gctaataatt attccaaatt aaacaaagaa       60

gaaagagaaa tcgaaataca taattccatg gcatcaagat attatgcaaa aacgatgttt      120

gcagcatttc aaatgttatt ttcaacaatg ttgagcaaca atgtagataa tcttgataaa      180

gcatatggat taagtgaaaa tatccaagta gcaacaagta cttccgcttt tcttactttt      240

gcatatgtat ataacggaag tataatggat agtgtgacta acagtttatt gccaccatat      300

gcgaagaaac ctataacaca attaaaatat ggaaaaacct tcgttttctc aaactatttc      360


<210>  78
<211>  1417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Met Val Ser Phe Phe Lys Thr Pro Ile Phe Ile Leu Ile Ile Phe Leu 
1               5                   10                  15      


Tyr Leu Asn Glu Lys Val Ile Cys Ser Ile Asn Glu Asn Gln Asn Glu 
            20                  25                  30          


Asn Asp Thr Ile Ser Gln Asn Val Asn Gln His Glu Asn Ile Asn Gln 
        35                  40                  45              


Asn Val Asn Asp Asn Asp Asn Ile Glu Gln Leu Lys Ser Met Ile Gly 
    50                  55                  60                  


Asn Asp Glu Leu His Lys Asn Leu Thr Ile Leu Glu Lys Leu Ile Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Lys Asp Lys Leu Lys Tyr Pro Leu Leu Lys Gln Gly 
                85                  90                  95      


Thr Glu Gln Leu Ile Asp Ile Ser Lys Phe Asn Lys Lys Asn Ile Thr 
            100                 105                 110         


Asp Ala Asp Asp Glu Thr Tyr Ile Ile Pro Thr Val Gln Ser Thr Phe 
        115                 120                 125             


His Asp Ile Val Lys Tyr Glu His Leu Ile Lys Glu Gln Ser Ile Glu 
    130                 135                 140                 


Ile Tyr Asn Ser Asp Ile Ser Asp Lys Ile Lys Lys Lys Ile Phe Ile 
145                 150                 155                 160 


Val Arg Thr Leu Lys Thr Ile Lys Leu Met Leu Ile Pro Leu Asn Ser 
                165                 170                 175     


Tyr Lys Gln Asn Asn Asp Leu Lys Ser Ala Leu Glu Glu Leu Asn Asn 
            180                 185                 190         


Val Phe Thr Asn Lys Glu Ala Gln Glu Glu Ser Ser Pro Ile Gly Asp 
        195                 200                 205             


His Gly Thr Phe Phe Arg Lys Leu Leu Thr His Val Arg Thr Ile Lys 
    210                 215                 220                 


Glu Asn Glu Asp Ile Glu Asn Lys Gly Glu Thr Leu Ile Leu Gly Asp 
225                 230                 235                 240 


Asn Lys Ile Asp Val Met Asn Ser Asn Asp Phe Phe Phe Thr Thr Asn 
                245                 250                 255     


Ser Asn Val Lys Phe Met Glu Asn Leu Asp Asp Ile Thr Asn Gln Tyr 
            260                 265                 270         


Gly Leu Gly Leu Ile Asn His Leu Gly Pro His Leu Ile Ala Leu Gly 
        275                 280                 285             


His Phe Thr Val Leu Lys Leu Ala Leu Lys Asn Tyr Lys Asn Tyr Phe 
    290                 295                 300                 


Glu Ala Lys Ser Ile Lys Phe Phe Ser Trp Gln Lys Ile Leu Glu Phe 
305                 310                 315                 320 


Ser Met Ser Asp Arg Phe Lys Val Leu Asp Met Met Cys Asn His Glu 
                325                 330                 335     


Ser Val Tyr Tyr Ser Glu Lys Lys Arg Arg Lys Thr Tyr Leu Lys Val 
            340                 345                 350         


Asp Arg Ser Ser Thr Ser Met Glu Cys Asn Ile Leu Glu Tyr Leu Leu 
        355                 360                 365             


His Tyr Phe Asn Lys Tyr Gln Leu Glu Ile Ile Lys Thr Thr Gln Asp 
    370                 375                 380                 


Thr Asp Phe Asp Leu His Gly Met Met Glu His Lys Tyr Ile Lys Asp 
385                 390                 395                 400 


Tyr Phe Phe Ser Phe Met Cys Asn Asp Pro Lys Glu Cys Ile Ile Tyr 
                405                 410                 415     


His Thr Asn Gln Phe Lys Lys Glu Ala Asn Glu Glu Asn Thr Phe Pro 
            420                 425                 430         


Glu Gln Glu Glu Pro Asn Arg Glu Ile Ser Ala Tyr Asn Leu Tyr Leu 
        435                 440                 445             


Asn Tyr Tyr Tyr Phe Met Lys Arg Tyr Ser Ser Tyr Gly Val Lys Lys 
    450                 455                 460                 


Thr Leu Tyr Val His Leu Leu Asn Leu Thr Gly Leu Leu Asn Tyr Asp 
465                 470                 475                 480 


Thr Arg Ser Tyr Val Thr Ser Leu Tyr Leu Pro Gly Tyr Tyr Asn Ala 
                485                 490                 495     


Val Glu Met Ser Phe Thr Glu Glu Lys Glu Phe Ser Lys Leu Phe Glu 
            500                 505                 510         


Ser Leu Ile Gln Cys Ile Glu Lys Cys His Ser Asp Gln Ala Arg Gln 
        515                 520                 525             


Ile Ser Lys Asp Ser Asn Leu Leu Asn Asp Ile Thr Lys Cys Asp Leu 
    530                 535                 540                 


Cys Lys Gly Ala Phe Leu Tyr Ser Asn Met Lys Phe Asp Glu Val Pro 
545                 550                 555                 560 


Ser Met Leu Gln Lys Phe Tyr Leu Tyr Leu Thr Lys Gly Leu Lys Ile 
                565                 570                 575     


Gln Lys Val Ser Ser Leu Ile Lys Thr Leu Asp Ile Tyr Gln Asp Tyr 
            580                 585                 590         


Ser Asn Phe Leu Ser His Asp Ile Asn Trp Tyr Thr Phe Leu Phe Leu 
        595                 600                 605             


Phe Arg Leu Thr Ser Phe Lys Glu Ile Ser Lys Lys Asn Val Ala Glu 
    610                 615                 620                 


Ala Met Tyr Leu Asn Ile Lys Asp Glu Asp Thr Phe Asn Lys Thr Ile 
625                 630                 635                 640 


Val Thr Asn Tyr Trp Tyr Pro Ser Pro Ile Lys Lys Tyr Tyr Thr Leu 
                645                 650                 655     


Tyr Val Arg Lys His Ile Pro Asn Asn Leu Val Asp Glu Leu Glu Lys 
            660                 665                 670         


Leu Met Lys Ser Gly Thr Leu Glu Lys Met Lys Lys Ser Leu Thr Phe 
        675                 680                 685             


Leu Val His Val Asn Ser Phe Leu Gln Leu Asp Phe Phe His Gln Leu 
    690                 695                 700                 


Asn Glu Pro Pro Leu Gly Leu Pro Arg Ser Tyr Pro Leu Ser Leu Val 
705                 710                 715                 720 


Leu Glu His Lys Phe Lys Glu Trp Met Asp Ser Ser Pro Ala Gly Phe 
                725                 730                 735     


Tyr Phe Ser Asn Tyr Gln Asn Pro Tyr Ile Arg Lys Asp Leu His Asp 
            740                 745                 750         


Lys Val Leu Ser Gln Lys Phe Glu Pro Pro Lys Met Asn Gln Trp Asn 
        755                 760                 765             


Lys Val Leu Lys Ser Leu Ile Glu Cys Ala Tyr Asp Met Tyr Phe Glu 
    770                 775                 780                 


Gln Arg His Val Lys Asn Leu Tyr Lys Tyr His Asn Ile Tyr Asn Ile 
785                 790                 795                 800 


Asn Asn Lys Leu Met Leu Met Arg Asp Ser Ile Asp Leu Tyr Lys Thr 
                805                 810                 815     


His Phe Asp Asp Val Leu Phe Phe Ala Asp Ile Phe Asn Met Arg Lys 
            820                 825                 830         


Tyr Met Thr Ala Thr Pro Val Tyr Lys Lys Val Lys Asp Arg Val Tyr 
        835                 840                 845             


His Thr Leu His Ser Ile Thr Gly Asn Ser Val Asn Phe Tyr Lys Tyr 
    850                 855                 860                 


Gly Ile Ile Tyr Gly Phe Lys Val Asn Lys Glu Ile Leu Lys Glu Val 
865                 870                 875                 880 


Val Asp Glu Leu Tyr Ser Ile Tyr Asn Phe Asn Thr Asp Ile Phe Thr 
                885                 890                 895     


Asp Thr Ser Phe Leu Gln Thr Val Tyr Leu Leu Phe Arg Arg Ile Glu 
            900                 905                 910         


Glu Thr Tyr Arg Thr Gln Arg Arg Asp Asp Lys Ile Ser Val Asn Asn 
        915                 920                 925             


Val Phe Phe Met Asn Val Ala Asn Asn Tyr Ser Lys Leu Asn Lys Glu 
    930                 935                 940                 


Glu Arg Glu Ile Glu Ile His Asn Ser Met Ala Ser Arg Tyr Tyr Ala 
945                 950                 955                 960 


Lys Thr Met Phe Ala Ala Phe Gln Met Leu Phe Ser Thr Met Leu Ser 
                965                 970                 975     


Asn Asn Val Asp Asn Leu Asp Lys Ala Tyr Gly Leu Ser Glu Asn Ile 
            980                 985                 990         


Gln Val Ala Thr Ser Thr Ser Ala  Phe Leu Thr Phe Ala  Tyr Val Tyr 
        995                 1000                 1005             


Asn Gly  Ser Ile Met Asp Ser  Val Thr Asn Ser Leu  Leu Pro Pro 
    1010                 1015                 1020             


Tyr Ala  Lys Lys Pro Ile Thr  Gln Leu Lys Tyr Gly  Lys Thr Phe 
    1025                 1030                 1035             


Val Phe  Ser Asn Tyr Phe Met  Leu Ala Ser Lys Met  Tyr Asp Met 
    1040                 1045                 1050             


Leu Asn  Tyr Lys Asn Leu Ser  Leu Leu Cys Glu Tyr  Gln Ala Val 
    1055                 1060                 1065             


Ala Ser  Ala Asn Phe Tyr Ser  Ala Lys Lys Val Gly  Gln Phe Ile 
    1070                 1075                 1080             


Gly Arg  Lys Phe Leu Pro Ile  Thr Thr Tyr Phe Leu  Val Met Arg 
    1085                 1090                 1095             


Ile Ser  Trp Thr His Ala Phe  Thr Thr Gly Gln His  Leu Ile Ala 
    1100                 1105                 1110             


Ala Phe  Asn Pro Pro Thr Ser  Thr Thr Asp Gly Lys  Cys Ser Ala 
    1115                 1120                 1125             


Pro Ser  Tyr Lys Ser Pro Glu  Ser Phe Phe Phe Thr  His Gly Leu 
    1130                 1135                 1140             


Ala Ala  Glu Ala Ser Lys Tyr  Leu Phe Phe Tyr Phe  Phe Thr Asn 
    1145                 1150                 1155             


Leu Tyr  Leu Asp Ala Tyr Lys  Ser Phe Pro Gly Gly  Phe Gly Pro 
    1160                 1165                 1170             


Ala Ile  Lys Glu Gln Thr Gln  His Val Gln Glu Gln  Thr Tyr Glu 
    1175                 1180                 1185             


Arg Lys  Pro Ser Val His Ser  Phe Asn Arg Asn Phe  Phe Met Glu 
    1190                 1195                 1200             


Leu Val  Asn Gly Phe Met Tyr  Ala Phe Cys Phe Phe  Ala Ile Ser 
    1205                 1210                 1215             


Gln Met  Tyr Ala Tyr Phe Glu  Asn Ile Asn Phe Tyr  Ile Thr Ser 
    1220                 1225                 1230             


Asn Phe  Arg Phe Leu Asp Arg  Tyr Tyr Gly Val Phe  Asn Lys Tyr 
    1235                 1240                 1245             


Phe Ile  Asn Tyr Ala Ile Ile  Lys Leu Lys Glu Ile  Thr Ser Asp 
    1250                 1255                 1260             


Leu Leu  Ile Lys Tyr Glu Arg  Glu Ala Tyr Leu Asn  Met Lys Lys 
    1265                 1270                 1275             


Tyr Gly  Tyr Leu Gly Glu Val  Ile Ala Ala Arg Leu  Ser Pro Lys 
    1280                 1285                 1290             


Asp Lys  Ile Met Asn Tyr Leu  His Glu Thr Asn Asp  Asp Val Met 
    1295                 1300                 1305             


Ser Asn  Leu Arg Arg Tyr Asp  Met Glu Asn Ala Phe  Lys Asn Lys 
    1310                 1315                 1320             


Met Val  Thr Tyr Val Asp Asp  Phe Ala Phe Phe Asp  Asp Cys Gly 
    1325                 1330                 1335             


Lys Asn  Glu Gln Phe Leu Asn  Glu Arg Cys Asp Tyr  Cys Pro Val 
    1340                 1345                 1350             


Ile Glu  Glu Val Glu Glu Thr  Glu Leu Phe Thr Thr  Thr Gly Asp 
    1355                 1360                 1365             


Lys Asn  Thr Asn Glu Thr Thr  Glu Ile Lys Lys Gln  Thr Ser Thr 
    1370                 1375                 1380             


Tyr Ile  Asp Thr Glu Lys Met  Asn Glu Ala Asp Ser  Ala Asp Ser 
    1385                 1390                 1395             


Asp Asp  Glu Lys Asp Phe Asp  Thr Pro Asp Asn Glu  Leu Met Ile 
    1400                 1405                 1410             


Ala Arg  Phe His 
    1415         


<210>  79
<211>  4251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
atggtttcat tttttaaaac tccaatcttt attttaatta tctttttata cttaaatgaa       60

aaggtaatat gttcaataaa tgaaaatcaa aatgaaaatg ataccattag tcaaaatgtc      120

aaccaacatg aaaatattaa tcaaaatgta aatgataatg acaatattga acaattaaaa      180

tccatgattg gaaatgatga actacataag aatttaacaa tattagaaaa attaatttta      240

gagtctttag aaaaagataa attaaaatat cctctcctta aacaaggaac tgaacaattg      300

atagatatat caaaatttaa taaaaaaaat attacagatg cggatgatga aacgtacatc      360

atacccaccg tccaatcaac gtttcacgat attgtgaaat acgaacatct tataaaagaa      420

caatcaatag aaatttacaa ttctgatata tcagataaaa ttaagaaaaa aatttttata      480

gtaagaacat tgaaaaccat aaaattaatg cttataccat taaactcgta caaacaaaat      540

aatgacttga aatctgcact cgaagaatta aataatgtat ttacaaacaa agaagctcaa      600

gaggaaagca gtccaatagg cgaccatggg acattcttta gaaaattgtt aacacatgtt      660

agaacaatta aagaaaatga agatatagaa aataaaggag aaacacttat attaggcgat      720

aataaaatag atgtaatgaa ttcaaacgat ttctttttta caaccaactc aaatgtaaaa      780

tttatggaaa atttagatga tataacaaat caatatggat taggtttgat taatcatcta      840

ggtcctcatt taatagcatt gggtcatttt accgtattaa aattagcact aaaaaattac      900

aaaaactatt ttgaagcaaa aagtattaaa ttttttagtt ggcaaaaaat tttagagttc      960

tccatgtccg atagatttaa ggttcttgat atgatgtgta accatgaatc tgtatattat     1020

tccgaaaaaa aacgtagaaa aacatattta aaagttgaca gatcaagcac atcgatggaa     1080

tgtaatatat tggaatattt attacattat tttaataaat accaactaga aataattaaa     1140

actacacaag atactgattt tgacttacat ggtatgatgg aacataaata tataaaagat     1200

tatttctttt catttatgtg taatgatcct aaggaatgta ttatttatca tacgaatcaa     1260

tttaaaaaag aagccaacga agaaaacaca tttcctgaac aagaagaacc taatcgtgaa     1320

ataagtgcat ataatttata tttaaattat tactatttca tgaaacgtta tagttcatat     1380

ggagtaaaaa aaacattata tgttcattta ttaaatttaa ctggactttt aaattatgat     1440

acaagatctt atgtgacatc actttattta ccaggatatt acaacgctgt cgaaatgtct     1500

tttacggaag aaaaagagtt ttccaaactt tttgaaagct taatacaatg tattgaaaaa     1560

tgccattcag accaagcaag gcaaatatca aaagatagta atttacttaa tgatataaca     1620

aaatgtgatt tgtgtaaagg agcattctta tattctaaca tgaaattcga tgaagttcct     1680

tcaatgttgc aaaaatttta cttatattta actaaaggtc tcaaaataca aaaagtatca     1740

tcactaatca aaacgctaga tatatatcaa gattacagta attttttatc acatgatatt     1800

aattggtaca cattcctatt tttatttaga cttacaagtt ttaaagaaat ttcaaagaaa     1860

aatgttgctg aagcaatgta tttaaatata aaagatgaag atacgttcaa caaaacgata     1920

gtaacaaact attggtaccc atctcctata aaaaaatatt atacattata cgttagaaaa     1980

cacataccaa ataatttagt agatgaattg gagaaattaa tgaaaagtgg cactttagaa     2040

aaaatgaaaa aatctctcac ctttttagta catgtgaatt catttttaca attagatttt     2100

tttcatcaac ttaatgaacc acctcttgga ttacctcgat catatccttt atccttagtt     2160

cttgaacata aatttaaaga atggatggac agttcgcccg ccggatttta tttttcaaat     2220

tatcaaaatc catatatcag aaaagatttg catgataaag ttttatcaca aaaatttgaa     2280

ccacctaaaa tgaatcagtg gaacaaagtt ttgaagtcat taattgaatg cgcatatgat     2340

atgtattttg aacagagaca tgttaaaaat ttatataaat atcataacat ttataatata     2400

aataacaaat taatgttaat gagagattca attgatttat ataaaaccca ttttgacgac     2460

gtattatttt ttgcggatat atttaatatg agaaaatata tgacagctac accagtatat     2520

aaaaaagtaa aagacagagt gtaccataca ttgcatagta ttacaggaaa ttctgtcaat     2580

ttttataaat atggtattat atatggattt aaagtaaaca aagaaatatt aaaagaagtt     2640

gtcgatgaat tgtattccat ctataatttt aacaccgaca tatttacgga tacttccttt     2700

ttacaaaccg tttatttatt atttagaaga atagaagaaa cttataggac ccaaagaaga     2760

gatgacaaaa taagtgtgaa taacgttttt ttcatgaatg ttgctaataa ttattccaaa     2820

ttaaacaaag aagaaagaga aatcgaaata cataattcca tggcatcaag atattatgca     2880

aaaacgatgt ttgcagcatt tcaaatgtta ttttcaacaa tgttgagcaa caatgtagat     2940

aatcttgata aagcatatgg attaagtgaa aatatccaag tagcaacaag tacttccgct     3000

tttcttactt ttgcatatgt atataacgga agtataatgg atagtgtgac taacagttta     3060

ttgccaccat atgcgaagaa acctataaca caattaaaat atggaaaaac cttcgttttc     3120

tcaaactatt tcatgctagc atccaaaatg tatgatatgt taaattataa aaatttaagt     3180

cttttatgtg aatatcaggc tgtggcaagt gccaatttct actctgctaa aaaggtaggt     3240

cagtttattg gaagaaaatt tttacccata actacatatt ttctagtaat gagaattagt     3300

tggacacatg cttttacaac tggacaacat ttgattgccg cttttaatcc cccaacttct     3360

actactgatg gtaaatgtag tgctcctagt tataaatccc ctgaaagttt tttctttact     3420

cacggacttg ctgctgaagc atccaaatat ttattttttt attttttcac aaatttatac     3480

cttgatgcct acaaatcttt tcctggagga tttggtcctg caataaaaga acaaactcaa     3540

catgttcaag aacaaacgta tgaacgcaaa ccatcagttc atagttttaa tagaaatttt     3600

ttcatggaac tcgtaaatgg attcatgtat gccttttgtt tttttgctat ttcacaaatg     3660

tatgcatatt ttgaaaatat taatttttat attacaagta atttccgttt cttggataga     3720

tattatggtg tattcaataa atattttata aactatgcca taattaaact taaagaaatt     3780

actagtgatc ttttaataaa atatgaacgt gaggcttatt taaatatgaa aaaatatggt     3840

tatttaggtg aagttattgc agctagactt tctcctaaag ataaaattat gaattatttg     3900

cacgaaacta acgacgatgt catgagtaat ttaagaagat atgatatgga aaatgctttc     3960

aaaaacaaaa tggttactta tgtggatgac tttgcttttt ttgatgattg tggcaaaaat     4020

gaacaatttt taaatgaaag atgtgattat tgtcctgtaa ttgaagaggt ggaagaaaca     4080

gaattattta ctaccactgg tgataaaaac actaatgaga ccacggaaat aaaaaaacaa     4140

actagtacat atattgatac tgaaaaaatg aatgaggcgg attccgctga tagcgacgat     4200

gaaaaggatt ttgatactcc tgacaatgaa ttaatgatcg cacgatttca t              4251


