                         SEQUENCE LISTING

<110>  Isis Innovation Limited
 
<120>  Composition

<130>  JA57156P.WOP

<150>  GB1106340.1
<151>  2011-04-11

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  485
<212>  PRT
<213>  Human immunodeficiency virus

<400>  1

Ser Pro Ser Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
1               5                   10                  15      


Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
            20                  25                  30          


Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
        35                  40                  45              


Pro Thr Asp Pro Asn Pro Gln Glu Val Glu Leu Glu Asn Val Thr Glu 
    50                  55                  60                  


Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
65                  70                  75                  80  


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
                85                  90                  95      


Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn 
            100                 105                 110         


Gly Asn Asp Thr Asn Thr Thr Ser Ser Ser Arg Glu Met Met Gly Gly 
        115                 120                 125             


Gly Glu Met Lys Asn Cys Ser Phe Lys Ile Thr Thr Asn Ile Arg Gly 
    130                 135                 140                 


Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Glu Leu Asp Ile Val Pro 
145                 150                 155                 160 


Ile Asp Asn Asn Ser Asn Asn Arg Tyr Arg Leu Ile Ser Cys Asn Thr 
                165                 170                 175     


Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro 
            180                 185                 190         


Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp 
        195                 200                 205             


Lys Lys Phe Asn Gly Lys Gly Pro Cys Ser Asn Val Ser Thr Val Gln 
    210                 215                 220                 


Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
225                 230                 235                 240 


Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Ala 
                245                 250                 255     


Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile 
            260                 265                 270         


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly 
        275                 280                 285             


Pro Gly Arg Ala Leu Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg 
    290                 295                 300                 


Gln Ala His Cys Asn Leu Ser Arg Ala Lys Trp Asn Asp Thr Leu Asn 
305                 310                 315                 320 


Lys Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val 
                325                 330                 335     


Phe Lys His Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe 
            340                 345                 350         


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn 
        355                 360                 365             


Ser Thr Trp Asn Val Thr Glu Glu Ser Asn Asn Thr Val Glu Asn Asn 
    370                 375                 380                 


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 


Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg 
                405                 410                 415     


Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Pro 
            420                 425                 430         


Glu Asp Asn Lys Thr Glu Val Phe Arg Pro Gly Gly Gly Asp Met Arg 
        435                 440                 445             


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
    450                 455                 460                 


Pro Leu Gly Val Ala Pro Thr Lys Ala Ile Ser Ser Val Val Lys His 
465                 470                 475                 480 


His His His His His 
                485 


<210>  2
<211>  485
<212>  PRT
<213>  Human immunodeficiency virus

<400>  2

Ser Pro Ser Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
1               5                   10                  15      


Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
            20                  25                  30          


Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
        35                  40                  45              


Pro Thr Asp Pro Asn Pro Gln Glu Val Glu Leu Glu Asn Val Thr Glu 
    50                  55                  60                  


Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
65                  70                  75                  80  


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
                85                  90                  95      


Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn 
            100                 105                 110         


Gly Asn Asp Thr Asn Thr Thr Ser Ser Ser Arg Glu Met Met Gly Gly 
        115                 120                 125             


Gly Glu Met Lys Asn Cys Ser Phe Lys Ile Thr Thr Asn Ile Arg Gly 
    130                 135                 140                 


Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Glu Leu Asp Ile Val Pro 
145                 150                 155                 160 


Ile Asp Asn Asn Ser Asn Asn Arg Tyr Arg Leu Ile Ser Cys Asn Thr 
                165                 170                 175     


Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro 
            180                 185                 190         


Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp 
        195                 200                 205             


Lys Lys Phe Asn Gly Lys Gly Pro Cys Ser Asn Val Ser Thr Val Gln 
    210                 215                 220                 


Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
225                 230                 235                 240 


Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Ala 
                245                 250                 255     


Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile 
            260                 265                 270         


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly 
        275                 280                 285             


Pro Gly Arg Ala Leu Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg 
    290                 295                 300                 


Gln Ala His Cys Asn Leu Ser Arg Ala Lys Trp Asn Asp Thr Leu Asn 
305                 310                 315                 320 


Lys Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val 
                325                 330                 335     


Phe Lys His Ser Ser Gly Gly Arg Pro Glu Ile Val Thr His Ser Phe 
            340                 345                 350         


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn 
        355                 360                 365             


Ser Thr Trp Asn Val Thr Glu Glu Ser Asn Asn Thr Val Glu Asn Asn 
    370                 375                 380                 


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 


Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg 
                405                 410                 415     


Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Pro 
            420                 425                 430         


Glu Asp Asn Lys Thr Glu Val Phe Arg Pro Gly Gly Gly Asp Met Arg 
        435                 440                 445             


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
    450                 455                 460                 


Pro Leu Gly Val Ala Pro Thr Lys Ala Ile Ser Ser Val Val Lys His 
465                 470                 475                 480 


His His His His His 
                485 


<210>  3
<211>  501
<212>  PRT
<213>  Human immunodeficiency virus

<400>  3

Ser Pro Ser Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
1               5                   10                  15      


Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
            20                  25                  30          


Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
        35                  40                  45              


Pro Thr Asp Pro Asn Pro Gln Glu Val Glu Leu Glu Asn Val Thr Glu 
    50                  55                  60                  


Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
65                  70                  75                  80  


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
                85                  90                  95      


Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn 
            100                 105                 110         


Gly Asn Asp Thr Asn Thr Thr Ser Ser Ser Arg Glu Met Met Gly Gly 
        115                 120                 125             


Gly Glu Met Lys Asn Cys Ser Phe Lys Ile Thr Thr Asn Ile Arg Gly 
    130                 135                 140                 


Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Glu Leu Asp Ile Val Pro 
145                 150                 155                 160 


Ile Asp Asn Asn Ser Asn Asn Arg Tyr Arg Leu Ile Ser Cys Asn Thr 
                165                 170                 175     


Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro 
            180                 185                 190         


Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp 
        195                 200                 205             


Lys Lys Phe Asn Gly Lys Gly Pro Cys Ser Asn Val Ser Thr Val Gln 
    210                 215                 220                 


Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
225                 230                 235                 240 


Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Ala 
                245                 250                 255     


Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile 
            260                 265                 270         


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly 
        275                 280                 285             


Pro Gly Arg Ala Leu Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg 
    290                 295                 300                 


Gln Ala His Cys Asn Leu Ser Arg Ala Lys Trp Asn Asp Thr Leu Asn 
305                 310                 315                 320 


Lys Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val 
                325                 330                 335     


Phe Lys His Ser Ser Gly Gly Arg Pro Glu Ile Val Thr His Ser Phe 
            340                 345                 350         


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn 
        355                 360                 365             


Ser Thr Trp Asn Val Thr Glu Glu Ser Asn Asn Thr Val Glu Asn Asn 
    370                 375                 380                 


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 


Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg 
                405                 410                 415     


Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Pro 
            420                 425                 430         


Glu Asp Asn Lys Thr Glu Val Phe Arg Pro Gly Gly Gly Asp Met Arg 
        435                 440                 445             


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
    450                 455                 460                 


Pro Leu Gly Val Ala Pro Thr Lys Ala Ile Ser Ser Val Val Gly Leu 
465                 470                 475                 480 


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Lys His 
                485                 490                 495     


His His His His His 
            500     


<210>  4
<211>  529
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  4

His His His His His His Gly Asp Pro Ser Lys Asp Ser Lys Ala Gln 
1               5                   10                  15      


Val Ser Ala Ala Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu 
            20                  25                  30          


Gly Ser Thr Phe Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly 
        35                  40                  45              


Thr Tyr Glu Ser Ala Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr 
    50                  55                  60                  


Gly Arg Tyr Asp Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu 
65                  70                  75                  80  


Gly Trp Thr Val Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala 
                85                  90                  95      


Thr Thr Trp Ser Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn 
            100                 105                 110         


Thr Gln Trp Leu Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys 
        115                 120                 125             


Ser Thr Leu Val Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala 
    130                 135                 140                 


Ala Ser Ile Asp Ala Ala Lys Lys Ala Gly Val Asn Asn Gly Asn Pro 
145                 150                 155                 160 


Leu Asp Ala Val Gln Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
            180                 185                 190         


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
        195                 200                 205             


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
    210                 215                 220                 


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
225                 230                 235                 240 


Asp Gln Val Ile Ala Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
                245                 250                 255     


Leu Gly Glu Ala Ile Arg Glu Ser Pro Glu Gln Ala Arg Leu Ala Leu 
            260                 265                 270         


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
        275                 280                 285             


Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala 
    290                 295                 300                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
305                 310                 315                 320 


Gly Ala Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
                325                 330                 335     


Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Gly Gly Tyr Val Phe 
            340                 345                 350         


Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe 
        355                 360                 365             


Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Ala Gly 
    370                 375                 380                 


Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp 
385                 390                 395                 400 


Gln Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg 
                405                 410                 415     


Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Ala Thr Ser Leu 
            420                 425                 430         


Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly 
        435                 440                 445             


His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Ser 
    450                 455                 460                 


Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr 
465                 470                 475                 480 


Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly 
                485                 490                 495     


Asp Leu Asp Pro Ser Ser Ile Pro Asp Ser Glu Ala Ala Ile Ser Ala 
            500                 505                 510         


Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu 
        515                 520                 525             


Lys 
    


