                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.
 
<120> ANTI-FGFR4 ANTIBODIES AND METHODS OF USE

<130> P4524R1 WO

<140>
<141>

<150> 61/473,106
<151> 2011-04-07

<160> 39    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Asn His Trp Met Asn 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Met Ile Leu Pro Val Asp Ser Glu Thr Thr Leu Glu Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Gly Asp Ile Ser Leu Phe Asp Tyr 
1               5               


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Arg Thr Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Tyr Thr Ser Arg Leu His Ser 
1               5           


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Gln Gln Gly Asn Ala Leu Pro Tyr Thr 
1               5                   


<210> 7
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Met Ile Leu Pro Val Asp Ser Glu Thr Thr Leu Glu Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Ile Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 8
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Phe Lys Ile Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ala Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 9
<211> 23
<212> PRT
<213> Homo sapiens

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210> 10
<211> 15
<212> PRT
<213> Homo sapiens

<400> 10
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Phe Lys Ile Leu Ile Ser 
1               5                   10                  15  


<210> 11
<211> 32
<212> PRT
<213> Homo sapiens

<400> 11
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210> 12
<211> 10
<212> PRT
<213> Homo sapiens

<400> 12
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210> 13
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10              


<210> 15
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 17
<211> 39
<212> PRT
<213> Mus sp.

<400> 17
Asp Val Pro Ala Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Asp Ser 
1               5                   10                  15      


Glu Thr Arg Ile Ile Leu Gln Gly Ser Pro Val Val Gln Met Ala Glu 
            20                  25                  30          


Asp Ala Val Asp Gly Glu Arg 
        35                  


<210> 18
<211> 19
<212> PRT
<213> Mus sp.

<400> 18
Arg Gln Glu Ala Leu Glu Leu Ile Lys Lys Gly Tyr Thr Gln Gln Leu 
1               5                   10                  15      


Ala Phe Lys 
            


<210> 19
<211> 18
<212> PRT
<213> Mus sp.

<400> 19
Ala Ala Phe Asn Asn Arg Pro Pro Ser Thr Trp Leu Thr Ala Tyr Val 
1               5                   10                  15      


Val Lys 
        


<210> 20
<211> 17
<212> PRT
<213> Mus sp.

<400> 20
Ala Ala Asn Leu Ile Ala Ile Asp Ser His Val Leu Cys Gly Ala Val 
1               5                   10                  15      


Lys 
    


<210> 21
<211> 23
<212> PRT
<213> Mus sp.

<400> 21
Gln Lys Pro Asp Gly Val Phe Gln Glu Asp Gly Pro Val Ile His Gln 
1               5                   10                  15      


Glu Met Ile Gly Gly Phe Arg 
            20              


<210> 22
<211> 64
<212> PRT
<213> Mus sp.

<400> 22
Glu Ala Asp Val Ser Leu Thr Ala Phe Val Leu Ile Ala Leu Gln Glu 
1               5                   10                  15      


Ala Arg Asp Ile Cys Glu Gly Gln Val Asn Ser Leu Pro Gly Ser Ile 
            20                  25                  30          


Asn Lys Ala Gly Glu Tyr Ile Glu Ala Ser Tyr Met Asn Leu Gln Arg 
        35                  40                  45              


Pro Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu Ala Leu Met Asn Lys 
    50                  55                  60                  


<210> 23
<211> 16
<212> PRT
<213> Mus sp.

<400> 23
Trp Glu Glu Pro Asp Gln Gln Leu Tyr Asn Val Glu Ala Thr Ser Tyr 
1               5                   10                  15      


<210> 24
<211> 30
<212> PRT
<213> Mus sp.

<400> 24
Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
1               5                   10                  15      


Gln Ala Leu Ala Gln Tyr Gln Thr Asp Val Pro Asp His Lys 
            20                  25                  30  


<210> 25
<211> 12
<212> PRT
<213> Mus sp.

<400> 25
Gly Thr Leu Ser Val Val Ala Val Tyr His Ala Lys 
1               5                   10          


<210> 26
<211> 11
<212> PRT
<213> Mus sp.

<400> 26
Asp Leu Glu Leu Leu Ala Ser Gly Val Asp Arg 
1               5                   10      


<210> 27
<211> 9
<212> PRT
<213> Mus sp.

<400> 27
Asn Thr Leu Ile Ile Tyr Leu Glu Lys 
1               5                   


<210> 28
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210> 29
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 30
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210> 31
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210> 32
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Ala Val Leu Leu Leu Leu Ala Gly Leu Tyr Arg Gly Lys Met Lys Ser 
1               5                   10                  15      


Gly 
    


<210> 33
<211> 81
<212> PRT
<213> Homo sapiens

<400> 33
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            20                  25                  30          


Pro Lys Leu Leu Ile Tyr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    50                  55                  60                  


Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


Arg 
    


<210> 34
<211> 108
<212> PRT
<213> Mus sp.

<400> 34
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Ile Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Thr Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ala Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu Arg 
            100                 105             


<210> 35
<211> 82
<212> PRT
<213> Homo sapiens

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
        35                  40                  45              


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
65                  70                  75                  80  


Ser Ser 
        


<210> 36
<211> 117
<212> PRT
<213> Mus sp.

<400> 36
Glu Val Gln Leu Gln Gln Pro Gly Ala Val Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Thr Leu Asp Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Arg Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Ile Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 37
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Thr Leu Asp Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Ile Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 38
<211> 1663
<212> PRT
<213> Mus sp.

<400> 38
Met Gly Pro Ala Ser Gly Ser Gln Leu Leu Val Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ser Pro Leu Ala Leu Gly Ile Pro Met Tyr Ser Ile Ile Thr 
            20                  25                  30          


Pro Asn Val Leu Arg Leu Glu Ser Glu Glu Thr Ile Val Leu Glu Ala 
        35                  40                  45              


His Asp Ala Gln Gly Asp Ile Pro Val Thr Val Thr Val Gln Asp Phe 
    50                  55                  60                  


Leu Lys Arg Gln Val Leu Thr Ser Glu Lys Thr Val Leu Thr Gly Ala 
65                  70                  75                  80  


Ser Gly His Leu Arg Ser Val Ser Ile Lys Ile Pro Ala Ser Lys Glu 
                85                  90                  95      


Phe Asn Ser Asp Lys Glu Gly His Lys Tyr Val Thr Val Val Ala Asn 
            100                 105                 110         


Phe Gly Glu Thr Val Val Glu Lys Ala Val Met Val Ser Phe Gln Ser 
        115                 120                 125             


Gly Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser 
    130                 135                 140                 


Thr Val Leu Tyr Arg Ile Phe Thr Val Asp Asn Asn Leu Leu Pro Val 
145                 150                 155                 160 


Gly Lys Thr Val Val Ile Leu Ile Glu Thr Pro Asp Gly Ile Pro Val 
                165                 170                 175     


Lys Arg Asp Ile Leu Ser Ser Asn Asn Gln His Gly Ile Leu Pro Leu 
            180                 185                 190         


Ser Trp Asn Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg 
        195                 200                 205             


Ala Phe Tyr Glu His Ala Pro Lys Gln Ile Phe Ser Ala Glu Phe Glu 
    210                 215                 220                 


Val Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Arg Val Glu Pro Thr 
225                 230                 235                 240 


Glu Thr Phe Tyr Tyr Ile Asp Asp Pro Asn Gly Leu Glu Val Ser Ile 
                245                 250                 255     


Ile Ala Lys Phe Leu Tyr Gly Lys Asn Val Asp Gly Thr Ala Phe Val 
            260                 265                 270         


Ile Phe Gly Val Gln Asp Gly Asp Lys Lys Ile Ser Leu Ala His Ser 
        275                 280                 285             


Leu Thr Arg Val Val Ile Glu Asp Gly Val Gly Asp Ala Val Leu Thr 
    290                 295                 300                 


Arg Lys Val Leu Met Glu Gly Val Arg Pro Ser Asn Ala Asp Ala Leu 
305                 310                 315                 320 


Val Gly Lys Ser Leu Tyr Val Ser Val Thr Val Ile Leu His Ser Gly 
                325                 330                 335     


Ser Asp Met Val Glu Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser 
            340                 345                 350         


Pro Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Phe Phe Lys Pro Ala 
        355                 360                 365             


Met Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro 
    370                 375                 380                 


Ala Ser Lys Val Leu Val Val Thr Gln Gly Ser Asn Ala Lys Ala Leu 
385                 390                 395                 400 


Thr Gln Asp Asp Gly Val Ala Lys Leu Ser Ile Asn Thr Pro Asn Ser 
                405                 410                 415     


Arg Gln Pro Leu Thr Ile Thr Val Arg Thr Lys Lys Asp Thr Leu Pro 
            420                 425                 430         


Glu Ser Arg Gln Ala Thr Lys Thr Met Glu Ala His Pro Tyr Ser Thr 
        435                 440                 445             


Met His Asn Ser Asn Asn Tyr Leu His Leu Ser Val Ser Arg Met Glu 
    450                 455                 460                 


Leu Lys Pro Gly Asp Asn Leu Asn Val Asn Phe His Leu Arg Thr Asp 
465                 470                 475                 480 


Pro Gly His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Val Met Asn 
                485                 490                 495     


Lys Gly Lys Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Ser Leu Pro Ile Thr Pro Glu Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Ile 
545                 550                 555                 560 


Gly Thr Leu Val Val Lys Gly Asp Pro Arg Asp Asn His Leu Ala Pro 
                565                 570                 575     


Gly Gln Gln Thr Thr Leu Arg Ile Glu Gly Asn Gln Gly Ala Arg Val 
            580                 585                 590         


Gly Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn 
        595                 600                 605             


Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile 
    610                 615                 620                 


Gly Cys Thr Pro Gly Ser Gly Lys Asn Tyr Ala Gly Val Phe Met Asp 
625                 630                 635                 640 


Ala Gly Leu Ala Phe Lys Thr Ser Gln Gly Leu Gln Thr Glu Gln Arg 
                645                 650                 655     


Ala Asp Leu Glu Cys Thr Lys Pro Ala Ala Arg Arg Arg Arg Ser Val 
            660                 665                 670         


Gln Leu Met Glu Arg Arg Met Asp Lys Ala Gly Gln Tyr Thr Asp Lys 
        675                 680                 685             


Gly Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Asp Ile Pro Met Arg 
    690                 695                 700                 


Tyr Ser Cys Gln Arg Arg Ala Arg Leu Ile Thr Gln Gly Glu Asn Cys 
705                 710                 715                 720 


Ile Lys Ala Phe Ile Asp Cys Cys Asn His Ile Thr Lys Leu Arg Glu 
                725                 730                 735     


Gln His Arg Arg Asp His Val Leu Gly Leu Ala Arg Ser Glu Leu Glu 
            740                 745                 750         


Glu Asp Ile Ile Pro Glu Glu Asp Ile Ile Ser Arg Ser His Phe Pro 
        755                 760                 765             


Gln Ser Trp Leu Trp Thr Ile Glu Glu Leu Lys Glu Pro Glu Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Val Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Leu Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Tyr Glu Ile Arg Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Phe Asn Tyr Arg Glu Gln Glu Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Met Ala Thr Ala Lys Asn 
865                 870                 875                 880 


Arg Tyr Phe Gln Thr Ile Lys Ile Pro Pro Lys Ser Ser Val Ala Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Ile Gly Gln Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Phe Asn His Phe Ile Ser Asp Gly Val Lys Lys Thr 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Met Arg Ile Asn Lys Thr Val Ala Ile 
    930                 935                 940                 


His Thr Leu Asp Pro Glu Lys Leu Gly Gln Gly Gly Val Gln Lys Val 
945                 950                 955                 960 


Asp Val Pro Ala Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Asp Ser 
                965                 970                 975     


Glu Thr Arg Ile Ile Leu Gln Gly Ser Pro Val Val Gln Met Ala Glu 
            980                 985                 990         


Asp Ala Val Asp Gly Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ala 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Gln  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Ile Glu  Lys Arg Gln Glu Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Lys  Gln Pro Ser Ser Ala  Tyr Ala Ala 
    1055                 1060                 1065             


Phe Asn  Asn Arg Pro Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Ala  Asn Leu Ile Ala Ile  Asp Ser His 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Gly Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Phe Arg Asn  Ala Lys Glu Ala Asp  Val Ser Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ala  Leu Gln Glu Ala Arg  Asp Ile Cys 
    1145                 1150                 1155             


Glu Gly  Gln Val Asn Ser Leu  Pro Gly Ser Ile Asn  Lys Ala Gly 
    1160                 1165                 1170             


Glu Tyr  Ile Glu Ala Ser Tyr  Met Asn Leu Gln Arg  Pro Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Leu Met Asn  Lys Leu Glu 
    1190                 1195                 1200             


Glu Pro  Tyr Leu Gly Lys Phe  Leu Asn Thr Ala Lys  Asp Arg Asn 
    1205                 1210                 1215             


Arg Trp  Glu Glu Pro Asp Gln  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Leu Leu Lys Asp  Phe Asp Ser 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Thr Asp  Val Pro Asp His Lys  Asp Leu Asn 
    1280                 1285                 1290             


Met Asp  Val Ser Phe His Leu  Pro Ser Arg Ser Ser  Ala Thr Thr 
    1295                 1300                 1305             


Phe Arg  Leu Leu Trp Glu Asn  Gly Asn Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Gln Asn Glu Ala Phe  Ser Leu Thr Ala Lys  Gly Lys Gly 
    1325                 1330                 1335             


Arg Gly  Thr Leu Ser Val Val  Ala Val Tyr His Ala  Lys Leu Lys 
    1340                 1345                 1350             


Ser Lys  Val Thr Cys Lys Lys  Phe Asp Leu Arg Val  Ser Ile Arg 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Ala Lys  Lys Pro Glu Glu Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Phe  Leu Glu Ile Cys Thr  Lys Tyr Leu Gly Asp  Val Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Lys Asp Leu Glu Leu  Leu Ala Ser Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Met Asn  Lys Ala Phe Ser Asn  Lys Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Glu Lys  Ile Ser His Thr Glu  Glu Asp Cys 
    1445                 1450                 1455             


Leu Thr  Phe Lys Val His Gln  Tyr Phe Asn Val Gly  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ser Val Lys Val Tyr  Ser Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Asp Asp Gly  Met Leu Ser 
    1490                 1495                 1500             


Lys Leu  Cys His Ser Glu Met  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Met  Gln Gln Ser Gln Glu  Lys Ile Asn Leu Asn  Val Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Glu 
    1535                 1540                 1545             


Leu Thr  Asn Ile Lys Leu Leu  Asp Asp Phe Asp Glu  Tyr Thr Met 
    1550                 1555                 1560             


Thr Ile  Gln Gln Val Ile Lys  Ser Gly Ser Asp Glu  Val Gln Ala 
    1565                 1570                 1575             


Gly Gln  Gln Arg Lys Phe Ile  Ser His Ile Lys Cys  Arg Asn Ala 
    1580                 1585                 1590             


Leu Lys  Leu Gln Lys Gly Lys  Lys Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Leu Trp Gly Glu Lys  Pro Asn Thr Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Ala Glu  Glu Cys Gln 
    1625                 1630                 1635             


Asp Gln  Lys Tyr Gln Lys Gln  Cys Glu Glu Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Tyr Gly  Cys Pro Asn 
    1655                 1660             


<210> 39
<211> 805
<212> PRT
<213> Homo sapiens

<400> 39
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr Glu Phe Thr 
                805 


