                         SEQUENCE LISTING

<110>  AlphaBeta AB
 
<120>  Amyloidosis target useful in methods of treatment and for 
       screening of compounds

<130>  PC-21056916

<150>  SE 1150299-4
<151>  2011-04-05

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Lys Val Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu Ala Lys 
1               5                   10                  15      


Lys Asp Glu Pro Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro Pro Asp 
            20                  25                  30          


Ala Val Ala Val Asp Cys Lys Asp Pro Asp Asp Val Val Pro Val Gly 
        35                  40                  45              


Gln Arg Arg Ala Trp Cys Trp Cys Met Cys Phe Gly Leu Ala Phe Met 
    50                  55                  60                  


Leu Ala Gly Val Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr Phe Ala 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Val Tyr Tyr Cys Gly Ile Lys Tyr Ile Lys Asp 
                85                  90                  95      


Asp Val Ile Leu Asn Glu Pro Ser Ala Asp Ala Pro Ala Ala Leu Tyr 
            100                 105                 110         


Gln Thr Ile Glu Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu Val Glu 
        115                 120                 125             


Phe Ile Ser Val Pro Val Pro Glu Phe Ala Asp Ser Asp Pro Ala Asn 
    130                 135                 140                 


Ile Val His Asp Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp Leu Asn 
145                 150                 155                 160 


Leu Asp Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro 
                165                 170                 175     


Pro Arg Asn Leu Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly Thr Tyr 
            180                 185                 190         


Leu Pro Gln Ser Tyr Leu Ile His Glu His Met Val Ile Thr Asp Arg 
        195                 200                 205             


Ile Glu Asn Ile Asp His Leu Gly Phe Phe Ile Tyr Arg Leu Cys His 
    210                 215                 220                 


Asp Lys Glu Thr Tyr Lys Leu Gln Arg Arg Glu Thr Ile Lys Gly Ile 
225                 230                 235                 240 


Gln Lys Arg Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn 
                245                 250                 255     


Lys Phe Ala Val Glu Thr Leu Ile Cys Ser 
            260                 265     


<210>  2
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Lys Tyr Ile Lys Asp Asp Val Ile Leu Asn Glu Pro Ser Ala 
1               5                   10                  15      


Asp Ala Pro Ala Ala Leu Tyr Gln Thr Ile Glu Glu Asn Ile Lys Ile 
            20                  25                  30          


Phe Glu Glu Glu Glu Val Glu Phe Ile Ser Val Pro Val Pro Glu Phe 
        35                  40                  45              


Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys Leu 
    50                  55                  60                  


Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro Leu 
65                  70                  75                  80  


Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu Ile 
                85                  90                  95      


Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His Glu 
            100                 105                 110         


His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly Phe 
        115                 120                 125             


Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu Gln Arg 
    130                 135                 140                 


Arg Glu Thr Ile Lys Gly Ile Gln Lys Arg 
145                 150                 


<210>  3
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys 
1               5                   10                  15      


Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro 
            20                  25                  30          


Leu Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu 
        35                  40                  45              


Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His 
    50                  55                  60                  


Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly 
65                  70                  75                  80  


Phe Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
                85                  90                  95  


<210>  4
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Lys Ile Ser Phe Gln Pro Ala Val Ala Gly Ile Lys Gly Asp 
1               5                   10                  15      


Lys Ala Asp Lys Ala Ser Ala Ser Ala Pro Ala Pro Ala Ser Ala Thr 
            20                  25                  30          


Glu Ile Leu Leu Thr Pro Ala Arg Glu Glu Gln Pro Pro Gln His Arg 
        35                  40                  45              


Ser Lys Arg Gly Gly Ser Val Gly Gly Val Cys Tyr Leu Ser Met Gly 
    50                  55                  60                  


Met Val Val Leu Leu Met Gly Leu Val Phe Ala Ser Val Tyr Ile Tyr 
65                  70                  75                  80  


Arg Tyr Phe Phe Leu Ala Gln Leu Ala Arg Asp Asn Phe Phe Arg Cys 
                85                  90                  95      


Gly Val Leu Tyr Glu Asp Ser Leu Ser Ser Gln Val Arg Thr Gln Met 
            100                 105                 110         


Glu Leu Glu Glu Asp Val Lys Ile Tyr Leu Asp Glu Asn Tyr Glu Arg 
        115                 120                 125             


Ile Asn Val Pro Val Pro Gln Phe Gly Gly Gly Asp Pro Ala Asp Ile 
    130                 135                 140                 


Ile His Asp Phe Gln Arg Gly Leu Thr Ala Tyr His Asp Ile Ser Leu 
145                 150                 155                 160 


Asp Lys Cys Tyr Val Ile Glu Leu Asn Thr Thr Ile Val Leu Pro Pro 
                165                 170                 175     


Arg Asn Phe Trp Glu Leu Leu Met Asn Val Lys Arg Gly Thr Tyr Leu 
            180                 185                 190         


Pro Gln Thr Tyr Ile Ile Gln Glu Glu Met Val Val Thr Glu His Val 
        195                 200                 205             


Ser Asp Lys Glu Ala Leu Gly Ser Phe Ile Tyr His Leu Cys Asn Gly 
    210                 215                 220                 


Lys Asp Thr Tyr Arg Leu Arg Arg Arg Ala Thr Arg Arg Arg Ile Asn 
225                 230                 235                 240 


Lys Arg Gly Ala Lys Asn Cys Asn Ala Ile Arg His Phe Glu Asn Thr 
                245                 250                 255     


Phe Val Val Glu Thr Leu Ile Cys Gly Val Val 
            260                 265         


<210>  5
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Val Leu Tyr Glu Asp Ser Leu Ser Ser Gln Val Arg Thr Gln Met 
1               5                   10                  15      


Glu Leu Glu Glu Asp Val Lys Ile Tyr Leu Asp Glu Asn Tyr Glu Arg 
            20                  25                  30          


Ile Asn Val Pro Val Pro Gln Phe Gly Gly Gly Asp Pro Ala Asp Ile 
        35                  40                  45              


Ile His Asp Phe Gln Arg Gly Leu Thr Ala Tyr His Asp Ile Ser Leu 
    50                  55                  60                  


Asp Lys Cys Tyr Val Ile Glu Leu Asn Thr Thr Ile Val Leu Pro Pro 
65                  70                  75                  80  


Arg Asn Phe Trp Glu Leu Leu Met Asn Val Lys Arg Gly Thr Tyr Leu 
                85                  90                  95      


Pro Gln Thr Tyr Ile Ile Gln Glu Glu Met Val Val Thr Glu His Val 
            100                 105                 110         


Ser Asp Lys Glu Ala Leu Gly Ser Phe Ile Tyr His Leu Cys Asn Gly 
        115                 120                 125             


Lys Asp Thr Tyr Arg Leu Arg Arg Arg Ala Thr Arg Arg Arg Ile Asn 
    130                 135                 140                 


Lys Arg 
145     


<210>  6
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Gly Gly Gly Asp Pro Ala Asp Ile Ile His Asp Phe Gln Arg Gly 
1               5                   10                  15      


Leu Thr Ala Tyr His Asp Ile Ser Leu Asp Lys Cys Tyr Val Ile Glu 
            20                  25                  30          


Leu Asn Thr Thr Ile Val Leu Pro Pro Arg Asn Phe Trp Glu Leu Leu 
        35                  40                  45              


Met Asn Val Lys Arg Gly Thr Tyr Leu Pro Gln Thr Tyr Ile Ile Gln 
    50                  55                  60                  


Glu Glu Met Val Val Thr Glu His Val Ser Asp Lys Glu Ala Leu Gly 
65                  70                  75                  80  


Ser Phe Ile Tyr His Leu Cys Asn Gly Lys Asp Thr Tyr Arg Leu 
                85                  90                  95  


<210>  7
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Val Gly Ser Lys Glu Val Leu Met Glu Ser Pro Pro Asp Tyr 
1               5                   10                  15      


Ser Ala Ala Pro Arg Gly Arg Phe Gly Ile Pro Cys Cys Pro Val His 
            20                  25                  30          


Leu Lys Arg Leu Leu Ile Val Val Val Val Val Val Leu Ile Val Val 
        35                  40                  45              


Val Ile Val Gly Ala Leu Leu Met Gly Leu His Met Ser Gln Lys His 
    50                  55                  60                  


Thr Glu Met Val Leu Glu Met Ser Ile Gly Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Arg Leu Ala Leu Ser Glu His Leu Val Thr Thr Ala Thr Phe Ser Ile 
                85                  90                  95      


Gly Ser Thr Gly Leu Val Val Tyr Asp Tyr Gln Gln Leu Leu Ile Ala 
            100                 105                 110         


Tyr Lys Pro Ala Pro Gly Thr Cys Cys Tyr Ile Met Lys Ile Ala Pro 
        115                 120                 125             


Glu Ser Ile Pro Ser Leu Glu Ala Leu Asn Arg Lys Val His Asn Phe 
    130                 135                 140                 


Gln Met Glu Cys Ser Leu Gln Ala Lys Pro Ala Val Pro Thr Ser Lys 
145                 150                 155                 160 


Leu Gly Gln Ala Glu Gly Arg Asp Ala Gly Ser Ala Pro Ser Gly Gly 
                165                 170                 175     


Asp Pro Ala Phe Leu Gly Met Ala Val Asn Thr Leu Cys Gly Glu Val 
            180                 185                 190         


Pro Leu Tyr Tyr Ile 
        195         


<210>  8
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  8

His Met Ser Gln Lys His Thr Glu Met Val Leu Glu Met Ser Ile Gly 
1               5                   10                  15      


Ala Pro Glu Ala Gln Gln Arg Leu Ala Leu Ser Glu His Leu Val Thr 
            20                  25                  30          


Thr Ala Thr Phe Ser Ile Gly Ser Thr Gly Leu Val Val Tyr Asp Tyr 
        35                  40                  45              


Gln Gln Leu Leu Ile Ala Tyr Lys Pro Ala Pro Gly Thr Cys Cys Tyr 
    50                  55                  60                  


Ile Met Lys Ile Ala Pro Glu Ser Ile Pro Ser Leu Glu Ala Leu Asn 
65                  70                  75                  80  


Arg Lys Val His Asn Phe Gln Met Glu Cys Ser Leu Gln Ala Lys Pro 
                85                  90                  95      


Ala Val Pro Thr Ser Lys Leu Gly Gln Ala Glu Gly Arg Asp Ala Gly 
            100                 105                 110         


Ser Ala Pro Ser Gly Gly Asp Pro Ala Phe Leu Gly Met Ala Val Asn 
        115                 120                 125             


Thr Leu Cys Gly Glu Val Pro Leu Tyr Tyr Ile 
    130                 135                 


<210>  9
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  9

Thr Thr Ala Thr Phe Ser Ile Gly Ser Thr Gly Leu Val Val Tyr Asp 
1               5                   10                  15      


Tyr Gln Gln Leu Leu Ile Ala Tyr Lys Pro Ala Pro Gly Thr Cys Cys 
            20                  25                  30          


Tyr Ile Met Lys Ile Ala Pro Glu Ser Ile Pro Ser Leu Glu Ala Leu 
        35                  40                  45              


Asn Arg Lys Val His Asn Phe Gln Met Glu Cys Ser Leu Gln Ala Lys 
    50                  55                  60                  


Pro Ala Val Pro Thr Ser Lys Leu Gly Gln Ala Glu Gly Arg Asp Ala 
65                  70                  75                  80  


Gly Ser Ala Pro Ser Gly Gly Asp Pro Ala Phe Leu Gly Met Ala Val 
                85                  90                  95      


Asn Thr Leu Cys Gly Glu Val Pro Leu Tyr Tyr Ile 
            100                 105             


<210>  10
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  11
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


