                         SEQUENCE LISTING

<110>  The UAB Research Foundation
       SONTHEIMER, Harald W.
       MONTANA PARPURA, Vedrana
 
<120>  Modulation of Cellular Migration

<130>  U2011-0048WO00

<150>  61/469,649
<151>  2011-03-30

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Pro Pro Gly Phe Ser Pro Phe Arg 
1               5                   


<210>  2
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Ser Pro Trp Lys Ile Ser Met Phe Leu Ser Val Arg Glu Asp 
1               5                   10                  15      


Ser Val Pro Thr Thr Ala Ser Phe Ser Ala Asp Met Leu Asn Val Thr 
            20                  25                  30          


Leu Gln Gly Pro Thr Leu Asn Gly Thr Phe Ala Gln Ser Lys Cys Pro 
        35                  40                  45              


Gln Val Glu Trp Leu Gly Trp Leu Asn Thr Ile Gln Pro Pro Phe Leu 
    50                  55                  60                  


Trp Val Leu Phe Val Leu Ala Thr Leu Glu Asn Ile Phe Val Leu Ser 
65                  70                  75                  80  


Val Phe Cys Leu His Lys Ser Ser Cys Thr Val Ala Glu Ile Tyr Leu 
                85                  90                  95      


Gly Asn Leu Ala Ala Ala Asp Leu Ile Leu Ala Cys Gly Leu Pro Phe 
            100                 105                 110         


Trp Ala Ile Thr Ile Ser Asn Asn Phe Asp Trp Leu Phe Gly Glu Thr 
        115                 120                 125             


Leu Cys Arg Val Val Asn Ala Ile Ile Ser Met Asn Leu Tyr Ser Ser 
    130                 135                 140                 


Ile Cys Phe Leu Met Leu Val Ser Ile Asp Arg Tyr Leu Ala Leu Val 
145                 150                 155                 160 


Lys Thr Met Ser Met Gly Arg Met Arg Gly Val Arg Trp Ala Lys Leu 
                165                 170                 175     


Tyr Ser Leu Val Ile Trp Gly Cys Thr Leu Leu Leu Ser Ser Pro Met 
            180                 185                 190         


Leu Val Phe Arg Thr Met Lys Glu Tyr Ser Asp Glu Gly His Asn Val 
        195                 200                 205             


Thr Ala Cys Val Ile Ser Tyr Pro Ser Leu Ile Trp Glu Val Phe Thr 
    210                 215                 220                 


Asn Met Leu Leu Asn Val Val Gly Phe Leu Leu Pro Leu Ser Val Ile 
225                 230                 235                 240 


Thr Phe Cys Thr Met Gln Ile Met Gln Val Leu Arg Asn Asn Glu Met 
                245                 250                 255     


Gln Lys Phe Lys Glu Ile Gln Thr Glu Arg Arg Ala Thr Val Leu Val 
            260                 265                 270         


Leu Val Val Leu Leu Leu Phe Ile Ile Cys Trp Leu Pro Phe Gln Ile 
        275                 280                 285             


Ser Thr Phe Leu Asp Thr Leu His Arg Leu Gly Ile Leu Ser Ser Cys 
    290                 295                 300                 


Gln Asp Glu Arg Ile Ile Asp Val Ile Thr Gln Ile Ala Ser Phe Met 
305                 310                 315                 320 


Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val Tyr Val Ile Val Gly 
                325                 330                 335     


Lys Arg Phe Arg Lys Lys Ser Trp Glu Val Tyr Gln Gly Val Cys Gln 
            340                 345                 350         


Lys Gly Gly Cys Arg Ser Glu Pro Ile Gln Met Glu Asn Ser Met Gly 
        355                 360                 365             


Thr Leu Arg Thr Ser Ile Ser Val Glu Arg Gln Ile His Lys Leu Gln 
    370                 375                 380                 


Asp Trp Ala Gly Ser Arg Gln 
385                 390     


<210>  3
<211>  391
<212>  PRT
<213>  Pan troglodytes

<400>  3

Met Phe Ser Pro Trp Lys Ile Pro Met Phe Leu Ser Val Arg Glu Asp 
1               5                   10                  15      


Ser Val Pro Thr Thr Ala Ser Phe Ser Thr Asp Met Leu Asn Val Thr 
            20                  25                  30          


Leu Gln Gly Pro Thr Leu Asn Gly Thr Phe Ala Gln Ser Lys Cys Pro 
        35                  40                  45              


Gln Val Glu Trp Leu Gly Trp Leu Asn Thr Ile Gln Pro Pro Phe Leu 
    50                  55                  60                  


Trp Val Leu Phe Val Leu Ala Thr Leu Glu Asn Ile Phe Val Leu Ser 
65                  70                  75                  80  


Val Phe Cys Leu His Lys Ser Ser Cys Thr Val Ala Glu Ile Tyr Leu 
                85                  90                  95      


Gly Asn Leu Ala Ala Ala Asp Leu Ile Leu Ala Cys Gly Leu Pro Phe 
            100                 105                 110         


Trp Ala Ile Thr Ile Ser Asn Asn Phe Asp Trp Leu Phe Gly Glu Thr 
        115                 120                 125             


Leu Cys Arg Val Val Asn Ala Ile Ile Ser Met Asn Leu Tyr Ser Ser 
    130                 135                 140                 


Ile Cys Phe Leu Met Leu Val Ser Ile Asp Arg Tyr Leu Ala Leu Val 
145                 150                 155                 160 


Lys Thr Met Ser Met Gly Arg Met Arg Gly Val Arg Trp Ala Lys Leu 
                165                 170                 175     


Tyr Ser Leu Val Ile Trp Gly Cys Thr Leu Leu Leu Ser Ser Pro Met 
            180                 185                 190         


Leu Val Phe Arg Thr Met Lys Glu Tyr Ser Asp Glu Gly His Asn Val 
        195                 200                 205             


Thr Ala Cys Val Ile Ser Tyr Pro Ser Leu Ile Trp Glu Val Phe Thr 
    210                 215                 220                 


Asn Met Leu Leu Asn Val Val Gly Phe Leu Leu Pro Leu Ser Val Ile 
225                 230                 235                 240 


Thr Phe Cys Thr Met Gln Ile Met Gln Val Leu Arg Asn Asn Glu Met 
                245                 250                 255     


Gln Lys Phe Lys Glu Ile Gln Thr Glu Arg Arg Ala Thr Val Leu Val 
            260                 265                 270         


Leu Val Val Leu Leu Leu Phe Ile Ile Cys Trp Leu Pro Phe Gln Ile 
        275                 280                 285             


Ser Thr Phe Leu Asp Thr Leu His Arg Leu Gly Ile Leu Ser Ser Cys 
    290                 295                 300                 


Gln Asp Glu Arg Ile Ile Asp Val Ile Thr Gln Ile Ala Ser Phe Met 
305                 310                 315                 320 


Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val Tyr Val Ile Val Gly 
                325                 330                 335     


Lys Arg Phe Arg Lys Lys Ser Trp Glu Val Tyr Gln Gly Val Cys Gln 
            340                 345                 350         


Lys Gly Gly Cys Arg Ser Glu Pro Ile Gln Met Glu Asn Ser Met Gly 
        355                 360                 365             


Thr Leu Arg Thr Ser Ile Ser Val Glu Arg Gln Ile His Lys Leu Gln 
    370                 375                 380                 


Asp Trp Ala Gly Ser Arg Gln 
385                 390     


<210>  4
<211>  392
<212>  PRT
<213>  Canis lupus

<400>  4

Met Phe Ser Ala Trp Lys Arg Pro Met Phe Leu Ser Phe His Glu Asp 
1               5                   10                  15      


Pro Val Pro Thr Thr Ala Ser Leu Ser Thr Glu Met Phe Asn Ser Thr 
            20                  25                  30          


Ser Gln Asp Leu Met Pro Thr Leu Asn Gly Thr Leu Pro Ser Pro Cys 
        35                  40                  45              


Val Tyr Pro Glu Trp Trp Asn Trp Leu Asn Thr Ile Gln Ala Pro Phe 
    50                  55                  60                  


Leu Trp Val Leu Phe Ile Leu Ala Ala Leu Glu Asn Leu Phe Val Leu 
65                  70                  75                  80  


Ser Ile Phe Cys Leu His Lys Ser Ser Cys Thr Val Ala Glu Ile Tyr 
                85                  90                  95      


Leu Gly Asn Leu Ala Leu Ala Asp Leu Ile Leu Ala Ser Gly Leu Pro 
            100                 105                 110         


Phe Trp Ala Ile Thr Ile Ala Asn Asn Phe Asp Trp Leu Phe Gly Glu 
        115                 120                 125             


Val Leu Cys Arg Val Val Asn Thr Met Leu Tyr Met Asn Leu Tyr Ser 
    130                 135                 140                 


Ser Ile Cys Phe Leu Met Leu Val Ser Ile Asp Arg Tyr Leu Ala Leu 
145                 150                 155                 160 


Val Lys Thr Met Ser Met Gly Arg Met Arg Gly Val Arg Trp Ala Lys 
                165                 170                 175     


Leu Tyr Ser Leu Val Ile Trp Gly Cys Thr Leu Leu Leu Ser Ser Pro 
            180                 185                 190         


Met Leu Ala Phe Arg Thr Met Lys Glu Tyr Arg Asp Glu Gly Tyr Asn 
        195                 200                 205             


Val Thr Ala Cys Val Ile Ile Tyr Pro Ser Arg Thr Trp Glu Val Phe 
    210                 215                 220                 


Thr Asn Val Leu Leu Asn Phe Val Gly Phe Leu Leu Pro Leu Thr Val 
225                 230                 235                 240 


Ile Thr Phe Cys Thr Val Gln Ile Met Gln Val Leu Arg Asn Asn Glu 
                245                 250                 255     


Met Gln Lys Phe Lys Glu Ile Gln Thr Glu Arg Lys Ala Thr Val Leu 
            260                 265                 270         


Val Leu Ala Val Leu Leu Leu Phe Val Ile Cys Trp Leu Pro Phe Gln 
        275                 280                 285             


Ile Ser Thr Phe Leu Asp Thr Leu Leu Arg Leu Asp Ile Leu Ser Gly 
    290                 295                 300                 


Cys Arg His Glu His Leu Val Asp Val Phe Thr Gln Ile Ala Ser Tyr 
305                 310                 315                 320 


Val Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val Tyr Val Ile Val 
                325                 330                 335     


Gly Lys Arg Phe Arg Lys Lys Ser Arg Glu Val Phe Arg Gly Leu Cys 
            340                 345                 350         


Gln Lys Gly Gly Cys Val Leu Glu Ser Asn Lys Met Asp Asn Ser Met 
        355                 360                 365             


Gly Thr Leu Arg Thr Ser Val Ser Val Glu Arg Gln Ile His Lys Leu 
    370                 375                 380                 


Pro Glu Trp Ala Glu Asn Ser Gln 
385                 390         


<210>  5
<211>  388
<212>  PRT
<213>  Bos taurus

<400>  5

Met Phe Ser Ala Trp Arg Arg Pro Met Phe Leu Ser Ile His Glu Asp 
1               5                   10                  15      


Thr Val Pro Thr Thr Ala Ser Phe Gly Ala Glu Met Phe Asn Leu Thr 
            20                  25                  30          


Ser Gln Val Leu Glu Pro Ala Leu Asn Gly Thr Leu Pro Glu Gly Ser 
        35                  40                  45              


Ser Cys Phe Gln Ser Asp Leu Trp Asn Trp Leu Asn Thr Ile Gln Pro 
    50                  55                  60                  


Pro Phe Leu Trp Ile Leu Phe Leu Leu Ala Ala Leu Glu Asn Thr Phe 
65                  70                  75                  80  


Val Leu Ser Val Phe Cys Leu His Lys Ser Ser Cys Thr Val Ala Glu 
                85                  90                  95      


Ile Tyr Leu Gly Asn Leu Ala Val Ala Asp Leu Ile Leu Ala Cys Gly 
            100                 105                 110         


Leu Pro Phe Trp Ala Ile Thr Ile Ala Asn Asn Phe Asp Trp Leu Phe 
        115                 120                 125             


Gly Glu Ala Leu Cys Arg Val Val Asn Thr Ile Leu Tyr Met Asn Leu 
    130                 135                 140                 


Tyr Ser Ser Ile Tyr Phe Leu Met Leu Val Ser Ile Asp Arg Tyr Leu 
145                 150                 155                 160 


Ala Leu Val Lys Thr Met Ser Met Gly Arg Met Arg Gly Val Arg Trp 
                165                 170                 175     


Ala Lys Leu Tyr Ser Leu Val Ile Trp Gly Cys Ala Leu Leu Leu Ser 
            180                 185                 190         


Ser Pro Met Leu Ala Phe Arg Thr Met Gln Glu Tyr Asn Ala Glu Gly 
        195                 200                 205             


His Asn Val Thr Ala Cys Val Ile Asn Tyr Pro Ser His Ser Trp Glu 
    210                 215                 220                 


Val Phe Thr Asn Ile Leu Leu Asn Ser Val Gly Phe Leu Leu Pro Leu 
225                 230                 235                 240 


Ser Val Ile Thr Phe Cys Thr Val Gln Ile Met Gln Val Leu Arg Asn 
                245                 250                 255     


Asn Glu Met Gln Lys Phe Lys Glu Ile Gln Thr Glu Arg Lys Ala Thr 
            260                 265                 270         


Leu Leu Val Leu Ala Val Leu Leu Leu Phe Val Val Cys Trp Leu Pro 
        275                 280                 285             


Phe Gln Ile Ser Thr Phe Leu Asp Thr Leu Leu Arg Leu His Val Leu 
    290                 295                 300                 


Ser Gly Cys Trp Asp Glu Tyr Val Ile Asp Ile Phe Thr Gln Ile Ala 
305                 310                 315                 320 


Ser Phe Val Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val Tyr Val 
                325                 330                 335     


Ile Val Gly Lys Arg Phe Arg Lys Lys Ser Gln Glu Val Tyr Ala Arg 
            340                 345                 350         


Leu Cys Arg Pro Gly Gly Cys Gly Ser Ala Glu Pro Ser Gln Thr Glu 
        355                 360                 365             


Asn Ser Met Gly Thr Leu Arg Thr Ser Ile Ser Val Glu Arg Asn Ile 
    370                 375                 380                 


His Lys Leu Gln 
385             


<210>  6
<211>  366
<212>  PRT
<213>  Mus musculus

<400>  6

Met Phe Asn Val Thr Thr Gln Val Leu Gly Ser Ala Leu Asn Gly Thr 
1               5                   10                  15      


Leu Ser Lys Asp Asn Cys Pro Asp Thr Glu Trp Trp Ser Trp Leu Asn 
            20                  25                  30          


Ala Ile Gln Ala Pro Phe Leu Trp Val Leu Phe Leu Leu Ala Ala Leu 
        35                  40                  45              


Glu Asn Leu Phe Val Leu Ser Val Phe Phe Leu His Lys Asn Ser Cys 
    50                  55                  60                  


Thr Val Ala Glu Ile Tyr Leu Gly Asn Leu Ala Ala Ala Asp Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Gly Leu Pro Phe Trp Ala Ile Thr Ile Ala Asn Asn Phe 
                85                  90                  95      


Asp Trp Val Phe Gly Glu Val Leu Cys Arg Val Val Asn Thr Met Ile 
            100                 105                 110         


Tyr Met Asn Leu Tyr Ser Ser Ile Cys Phe Leu Met Leu Val Ser Ile 
        115                 120                 125             


Asp Arg Tyr Leu Ala Leu Val Lys Thr Met Ser Met Gly Arg Met Arg 
    130                 135                 140                 


Gly Val Arg Trp Ala Lys Leu Tyr Ser Leu Val Ile Trp Gly Cys Thr 
145                 150                 155                 160 


Leu Leu Leu Ser Ser Pro Met Leu Val Phe Arg Thr Met Arg Glu Tyr 
                165                 170                 175     


Ser Glu Glu Gly His Asn Val Thr Ala Cys Val Ile Val Tyr Pro Ser 
            180                 185                 190         


Arg Ser Trp Glu Val Phe Thr Asn Val Leu Leu Asn Leu Val Gly Phe 
        195                 200                 205             


Leu Leu Pro Leu Ser Val Ile Thr Phe Cys Thr Val Arg Ile Leu Gln 
    210                 215                 220                 


Val Leu Arg Asn Asn Glu Met Lys Lys Phe Lys Glu Val Gln Thr Glu 
225                 230                 235                 240 


Arg Lys Ala Thr Val Leu Val Leu Ala Val Leu Gly Leu Phe Val Leu 
                245                 250                 255     


Cys Trp Val Pro Phe Gln Ile Ser Thr Phe Leu Asp Thr Leu Leu Arg 
            260                 265                 270         


Leu Gly Val Leu Ser Gly Cys Trp Asp Glu His Ala Val Asp Val Ile 
        275                 280                 285             


Thr Gln Ile Ser Ser Tyr Val Ala Tyr Ser Asn Ser Gly Leu Asn Pro 
    290                 295                 300                 


Leu Val Tyr Val Ile Val Gly Lys Arg Phe Arg Lys Lys Ser Arg Glu 
305                 310                 315                 320 


Val Tyr Arg Val Leu Cys Gln Lys Gly Gly Cys Met Gly Glu Pro Val 
                325                 330                 335     


Gln Met Glu Asn Ser Met Gly Thr Leu Arg Thr Ser Ile Ser Val Glu 
            340                 345                 350         


Arg Gln Ile His Lys Leu Gln Asp Trp Ala Gly Lys Lys Gln 
        355                 360                 365     


<210>  7
<211>  366
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Phe Asn Ile Thr Thr Gln Ala Leu Gly Ser Ala His Asn Gly Thr 
1               5                   10                  15      


Phe Ser Glu Val Asn Cys Pro Asp Thr Glu Trp Trp Ser Trp Leu Asn 
            20                  25                  30          


Ala Ile Gln Ala Pro Phe Leu Trp Val Leu Phe Leu Leu Ala Ala Leu 
        35                  40                  45              


Glu Asn Ile Phe Val Leu Ser Val Phe Cys Leu His Lys Thr Asn Cys 
    50                  55                  60                  


Thr Val Ala Glu Ile Tyr Leu Gly Asn Leu Ala Ala Ala Asp Leu Ile 
65                  70                  75                  80  


Leu Ala Cys Gly Leu Pro Phe Trp Ala Ile Thr Ile Ala Asn Asn Phe 
                85                  90                  95      


Asp Trp Leu Phe Gly Glu Val Leu Cys Arg Val Val Asn Thr Met Ile 
            100                 105                 110         


Tyr Met Asn Leu Tyr Ser Ser Ile Cys Phe Leu Met Leu Val Ser Ile 
        115                 120                 125             


Asp Arg Tyr Leu Ala Leu Val Lys Thr Met Ser Met Gly Arg Met Arg 
    130                 135                 140                 


Gly Val Arg Trp Ala Lys Leu Tyr Ser Leu Val Ile Trp Ser Cys Thr 
145                 150                 155                 160 


Leu Leu Leu Ser Ser Pro Met Leu Val Phe Arg Thr Met Lys Asp Tyr 
                165                 170                 175     


Arg Glu Glu Gly His Asn Val Thr Ala Cys Val Ile Val Tyr Pro Ser 
            180                 185                 190         


Arg Ser Trp Glu Val Phe Thr Asn Met Leu Leu Asn Leu Val Gly Phe 
        195                 200                 205             


Leu Leu Pro Leu Ser Ile Ile Thr Phe Cys Thr Val Arg Ile Met Gln 
    210                 215                 220                 


Val Leu Arg Asn Asn Glu Met Lys Lys Phe Lys Glu Val Gln Thr Glu 
225                 230                 235                 240 


Lys Lys Ala Thr Val Leu Val Leu Ala Val Leu Gly Leu Phe Val Leu 
                245                 250                 255     


Cys Trp Phe Pro Phe Gln Ile Ser Thr Phe Leu Asp Thr Leu Leu Arg 
            260                 265                 270         


Leu Gly Val Leu Ser Gly Cys Trp Asn Glu Arg Ala Val Asp Ile Val 
        275                 280                 285             


Thr Gln Ile Ser Ser Tyr Val Ala Tyr Ser Asn Ser Cys Leu Asn Pro 
    290                 295                 300                 


Leu Val Tyr Val Ile Val Gly Lys Arg Phe Arg Lys Lys Ser Arg Glu 
305                 310                 315                 320 


Val Tyr Gln Ala Ile Cys Arg Lys Gly Gly Cys Met Gly Glu Ser Val 
                325                 330                 335     


Gln Met Glu Asn Ser Met Gly Thr Leu Arg Thr Ser Ile Ser Val Asp 
            340                 345                 350         


Arg Gln Ile His Lys Leu Gln Asp Trp Ala Gly Asn Lys Gln 
        355                 360                 365     


<210>  8
<211>  381
<212>  PRT
<213>  Gallus gallus

<400>  8

Met Ile Thr Ile Thr Thr Glu Asn Val Thr Gln Leu Tyr Asn Val Thr 
1               5                   10                  15      


Ala Thr Gln Glu Phe Thr Ile Ser Pro Ala Glu Phe His Asn Asn Ser 
            20                  25                  30          


Ser Val His Gln Met Asp Glu Tyr Lys Cys Ile Asn Pro Asp Thr Trp 
        35                  40                  45              


Lys Trp Leu Gln Thr Phe Gln Pro Gly Phe Leu Trp Ile Ile Phe Ile 
    50                  55                  60                  


Leu Gly Thr Ile Glu Asn Ala Phe Val Leu Ile Val Leu Tyr Phe His 
65                  70                  75                  80  


Lys Ser Arg Cys Ser Val Ala Glu Ile Tyr Leu Ala Asn Met Ala Phe 
                85                  90                  95      


Ala Asp Leu Met Leu Val Cys Ser Leu Pro Phe Trp Ala Ile Asn Ile 
            100                 105                 110         


Ser Asn Gly Phe Gln Trp Pro Phe Gly Leu Phe Leu Cys Lys Ala Val 
        115                 120                 125             


Asn Thr Ile Asn Tyr Met Asn Ser Tyr Ser Ser Ile Tyr Phe Leu Thr 
    130                 135                 140                 


Leu Val Ser Ile Asp Arg Tyr Leu Ala Leu Val Lys Thr Met Ser Leu 
145                 150                 155                 160 


Gly Arg Met Arg Arg Thr Ala Cys Ala Lys Trp Asn Ser Leu Ile Ile 
                165                 170                 175     


Trp Met Cys Ala Leu Leu Ile Cys Ser Pro Thr Met Val Phe Arg Asn 
            180                 185                 190         


Leu Gln Tyr Phe Lys Glu Tyr Asn Ile Thr Ala Cys Ser Leu Asp Tyr 
        195                 200                 205             


Pro Thr Pro Tyr Trp His Pro Ala Asn Asn Cys Leu Leu Asn Ala Val 
    210                 215                 220                 


Gly Phe Met Ile Pro Leu Cys Ile Ile Thr Tyr Cys Thr Thr Gln Ile 
225                 230                 235                 240 


Ile Lys Ala Leu Gln Ser Asn Lys Ser Gln Lys Leu Lys Leu Ile Gln 
                245                 250                 255     


Thr Glu Arg Lys Ala Thr Leu Leu Val Leu Ala Val Leu Leu Leu Phe 
            260                 265                 270         


Val Ile Cys Trp Leu Pro Phe Gln Ile Ser Thr Leu Ile Asp Thr Val 
        275                 280                 285             


Cys Tyr Leu Ala Gly Asn Leu Lys Cys Leu Glu Asp Ile Asn Asp Ile 
    290                 295                 300                 


Val Thr Gln Met Ala Ile Tyr Cys Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Ile Leu Tyr Val Ile Val Gly Lys His Phe Gln Lys Lys Ala Val 
                325                 330                 335     


Glu Leu Phe Lys Asp Leu Ile Pro Gln Arg Cys Arg Lys Ser Glu Ser 
            340                 345                 350         


Val Lys Ile Glu Asn Ser Gln Asp Thr Leu Arg Thr Ser Ile Ser Ser 
        355                 360                 365             


Glu His Leu Arg Lys Lys Ser Val Leu Pro Leu Ser Gln 
    370                 375                 380     


<210>  9
<211>  356
<212>  PRT
<213>  Danio rerio

<400>  9

Met Asp Pro Glu Ile Gln Leu Thr Thr Ser Ser Ser Ile Leu Ser Thr 
1               5                   10                  15      


Ile Pro Ser Thr Asn Asn Leu Thr Asn Ala Thr Gln Cys Pro His Trp 
            20                  25                  30          


Glu Val Trp Asp Trp Leu Tyr Val Met Gln Pro Ala Tyr Met Phe Ile 
        35                  40                  45              


Ile Cys Val Leu Gly Ile Ile Gly Asn Ile Phe Val Leu Leu Val Phe 
    50                  55                  60                  


Ser Leu His Lys Lys Ala Cys Thr Val Ala Glu Ile Tyr Leu Gly Asn 
65                  70                  75                  80  


Leu Ala Ala Ala Asp Leu Leu Leu Val Ser Cys Leu Pro Phe Trp Ala 
                85                  90                  95      


Ile Asn Ile Ala Asn Glu Phe Asn Trp Glu Phe Gly Ser Ala Met Cys 
            100                 105                 110         


Arg Leu Val Asn Thr Gly Ile Lys Met Asn Met Leu Cys Ser Ile Tyr 
        115                 120                 125             


Phe Leu Val Leu Val Ser Thr Asp Arg Tyr Val Ala Leu Val His Ala 
    130                 135                 140                 


Leu Ser Arg Gly Arg Met Arg Arg Pro Arg Tyr Ala Lys Leu Asn Cys 
145                 150                 155                 160 


Ile Ala Val Trp Cys Phe Gly Leu Ile Leu Asn Ile Pro Thr Leu His 
                165                 170                 175     


Phe Arg Asp Ile Lys Phe Ile Pro Glu Leu Asn Ile Thr Ala Cys Ile 
            180                 185                 190         


Leu Asp Tyr Pro Asn Pro Asn Ile Gly Leu Ile Cys Asp Ile Leu Leu 
        195                 200                 205             


Met Ile Ile Gly Phe Ile Ile Pro Ile Leu Val Ile Ser Tyr Cys Thr 
    210                 215                 220                 


Leu Lys Ile Ile Arg Ala Leu His Glu Gln Val Val Asp Arg Phe Asn 
225                 230                 235                 240 


Ala Glu Asn Thr Glu Arg Lys Ala Thr Ile Leu Val Leu Val Val Leu 
                245                 250                 255     


Met Val Phe Leu Leu Cys Trp Val Pro Phe His Leu Val Thr Leu Met 
            260                 265                 270         


Asp Val Leu Met Arg Phe Gly Val Phe Ser Gly Cys Thr Phe Glu Ala 
        275                 280                 285             


Gly Leu Asp Ile Ser Asn Gln Ile Phe Thr Tyr Leu Ala Leu Ser Asn 
    290                 295                 300                 


Ser Val Leu Asn Pro Ile Leu Tyr Val Ile Val Gly Lys Asn Phe Arg 
305                 310                 315                 320 


Lys Lys Val Lys Glu Leu Met Lys Gln Leu Asn Glu Lys Lys Ala Asp 
                325                 330                 335     


Ser Thr Ser Gly Ser Thr Arg Ser Gln Leu Ser Ser Thr Leu Lys Thr 
            340                 345                 350         


Phe Thr Thr Tyr 
        355     


<210>  10
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210>  11
<211>  502
<212>  PRT
<213>  Pan troglodytes

<400>  11

Met Gln Glu Leu Ala Cys Leu Gly Ser Ser Ala Ser Gly His Ser Asp 
1               5                   10                  15      


Leu Ser Gly Val Arg Gly Ala Leu Pro Ile Ala Gly Leu Arg Pro Asn 
            20                  25                  30          


Pro Thr Pro Pro Gly Tyr Ala Arg Gly Phe Cys Gln Gly His Pro Gly 
        35                  40                  45              


Ile Ala Ser Pro Ala His Ser Phe Ile Lys Pro Ser His Pro Arg Ser 
    50                  55                  60                  


Glu Gln Ser Gln Ser Arg Met Glu Arg Arg Arg Ile Thr Ser Ala Ala 
65                  70                  75                  80  


Arg Arg Ser Tyr Val Ser Ser Gly Glu Met Met Val Gly Gly Leu Ala 
                85                  90                  95      


Pro Gly Arg Arg Leu Gly Pro Gly Thr Arg Leu Ser Leu Ala Arg Met 
            100                 105                 110         


Pro Pro Pro Leu Pro Thr Arg Val Asp Phe Ser Leu Ala Gly Ala Leu 
        115                 120                 125             


Asn Ala Gly Phe Lys Glu Thr Arg Ala Ser Glu Arg Ala Glu Met Met 
    130                 135                 140                 


Glu Leu Asn Asp Arg Phe Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu 
145                 150                 155                 160 


Glu Gln Gln Asn Lys Ala Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala 
                165                 170                 175     


Lys Glu Pro Thr Lys Leu Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu 
            180                 185                 190         


Leu Arg Leu Arg Leu Asp Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu 
        195                 200                 205             


Val Glu Arg Asp Asn Leu Ala Gln Asp Leu Ala Thr Val Arg Gln Lys 
    210                 215                 220                 


Leu Gln Asp Glu Thr Asn Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala 
225                 230                 235                 240 


Ala Tyr Arg Gln Glu Ala Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu 
                245                 250                 255     


Glu Arg Lys Ile Glu Ser Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys 
            260                 265                 270         


Ile His Glu Glu Glu Val Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln 
        275                 280                 285             


Gln Val His Val Glu Leu Asp Val Ala Lys Pro Asp Leu Thr Ala Ala 
    290                 295                 300                 


Leu Lys Glu Ile Arg Thr Gln Tyr Glu Ala Met Ala Ser Ser Asn Met 
305                 310                 315                 320 


His Glu Ala Glu Glu Trp Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp 
                325                 330                 335     


Ala Ala Ala Arg Asn Ala Glu Leu Leu Arg Gln Ala Lys His Glu Ala 
            340                 345                 350         


Asn Asp Tyr Arg Arg Gln Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser 
        355                 360                 365             


Leu Arg Gly Thr Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Gln Glu 
    370                 375                 380                 


Glu Arg His Val Arg Glu Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg 
385                 390                 395                 400 


Leu Glu Glu Glu Gly Gln Ser Leu Lys Asp Glu Met Ala Arg His Leu 
                405                 410                 415     


Gln Glu Tyr Gln Asp Leu Leu Asn Val Lys Leu Ala Leu Asp Ile Glu 
            420                 425                 430         


Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr 
        435                 440                 445             


Ile Pro Val Gln Thr Phe Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu 
    450                 455                 460                 


Asp Thr Lys Ser Val Ser Glu Gly His Leu Lys Arg Asn Ile Val Val 
465                 470                 475                 480 


Lys Thr Val Glu Met Arg Asp Gly Glu Val Ile Lys Glu Ser Lys Gln 
                485                 490                 495     


Glu His Lys Asp Val Met 
            500         


<210>  12
<211>  433
<212>  PRT
<213>  Canis lupus

<400>  12

Met Glu Arg Arg Arg Val Ala Ser Ala Ala Arg Arg Ser Tyr Val Tyr 
1               5                   10                  15      


Val Ser Ser Trp Asp Met Ala Gly Gly Gly Pro Gly Ser Gly Arg Arg 
            20                  25                  30          


Leu Gly Pro Gly Pro Arg Pro Ser Val Ala Arg Met Pro Leu Pro Pro 
        35                  40                  45              


Thr Arg Val Asp Phe Ser Leu Ala Ala Ala Leu Asn Ala Gly Phe Lys 
    50                  55                  60                  


Glu Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg 
65                  70                  75                  80  


Phe Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys 
                85                  90                  95      


Ala Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys 
            100                 105                 110         


Leu Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu 
        115                 120                 125             


Asp Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn 
    130                 135                 140                 


Leu Ala Gln Asp Leu Gly Thr Leu Arg Gln Lys Phe Gln Asp Glu Thr 
145                 150                 155                 160 


Asn Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ser Tyr Arg Gln Glu 
                165                 170                 175     


Ala Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu 
            180                 185                 190         


Ser Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Asp Glu Glu 
        195                 200                 205             


Val Gln Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu 
    210                 215                 220                 


Leu Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Arg Glu Ile Arg 
225                 230                 235                 240 


Thr Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu 
                245                 250                 255     


Trp Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn 
            260                 265                 270         


Ala Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg 
        275                 280                 285             


Gln Leu Gln Thr Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn 
    290                 295                 300                 


Glu Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Ala Arg 
305                 310                 315                 320 


Glu Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly 
                325                 330                 335     


Gln Asn Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp 
            340                 345                 350         


Leu Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg 
        355                 360                 365             


Lys Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr 
    370                 375                 380                 


Phe Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val 
385                 390                 395                 400 


Ser Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met 
                405                 410                 415     


Arg Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Glu Val 
            420                 425                 430         


Met 
    


<210>  13
<211>  428
<212>  PRT
<213>  Bos taurus

<400>  13

Met Glu Arg Arg Arg Val Thr Ser Ala Thr Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Ser Glu Met Val Val Gly Gly Arg Arg Leu Gly Pro Gly Thr Arg 
            20                  25                  30          


Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Ala Arg Val Asp Phe 
        35                  40                  45              


Ser Leu Ala Gly Ala Leu Asn Ser Gly Phe Lys Glu Thr Arg Ala Ser 
    50                  55                  60                  


Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe Ala Ser Tyr Ile 
65                  70                  75                  80  


Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala Leu Ala Ala Glu 
                85                  90                  95      


Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu Ala Asp Val Tyr 
            100                 105                 110         


Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp Gln Leu Thr Ala 
        115                 120                 125             


Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu Ala Gln Asp Leu 
    130                 135                 140                 


Gly Thr Leu Arg Gln Lys Leu Gln Asp Glu Thr Asn Gln Arg Leu Glu 
145                 150                 155                 160 


Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala Asp Glu Ala Thr 
                165                 170                 175     


Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser Leu Glu Glu Glu 
            180                 185                 190         


Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val Arg Glu Leu Gln 
        195                 200                 205             


Glu Gln Leu Ala Gln Gln Gln Val His Val Glu Met Asp Val Ala Lys 
    210                 215                 220                 


Pro Asp Leu Thr Ala Ala Leu Arg Glu Ile Arg Thr Gln Tyr Glu Ala 
225                 230                 235                 240 


Val Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp Tyr Arg Ser Lys 
                245                 250                 255     


Phe Ala Asp Leu Asn Asp Ala Ala Ala Arg Asn Ala Glu Leu Leu Arg 
            260                 265                 270         


Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln Leu Gln Ala Leu 
        275                 280                 285             


Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu Ser Leu Glu Arg 
    290                 295                 300                 


Gln Met Arg Glu Gln Glu Glu Arg His Ala Arg Glu Ala Ala Ser Tyr 
305                 310                 315                 320 


Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln Ser Leu Lys Asp 
                325                 330                 335     


Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu Leu Asn Val Lys 
            340                 345                 350         


Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly 
        355                 360                 365             


Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe Ser Asn Leu Gln 
    370                 375                 380                 


Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser Glu Gly His Leu 
385                 390                 395                 400 


Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg Asp Gly Glu Val 
                405                 410                 415     


Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425             


<210>  14
<211>  430
<212>  PRT
<213>  Mus musculus

<400>  14

Met Glu Arg Arg Arg Ile Thr Ser Ala Arg Arg Ser Tyr Ala Ser Glu 
1               5                   10                  15      


Thr Val Val Arg Gly Leu Gly Pro Ser Arg Gln Leu Gly Thr Met Pro 
            20                  25                  30          


Arg Phe Ser Leu Ser Arg Met Thr Pro Pro Leu Pro Ala Arg Val Asp 
        35                  40                  45              


Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu Thr Arg Ala 
    50                  55                  60                  


Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe Ala Ser Tyr 
65                  70                  75                  80  


Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala Leu Ala Ala 
                85                  90                  95      


Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu Ala Asp Val 
            100                 105                 110         


Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp Gln Leu Thr 
        115                 120                 125             


Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Phe Ala Gln Asp 
    130                 135                 140                 


Leu Gly Thr Leu Arg Gln Lys Leu Gln Asp Glu Thr Asn Leu Arg Leu 
145                 150                 155                 160 


Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala Asp Glu Ala 
                165                 170                 175     


Thr Leu Ala Arg Val Asp Leu Glu Arg Lys Val Glu Ser Leu Glu Glu 
            180                 185                 190         


Glu Ile Gln Phe Leu Arg Lys Ile Tyr Glu Glu Glu Val Arg Glu Leu 
        195                 200                 205             


Arg Glu Gln Leu Ala Gln Gln Gln Val His Val Glu Met Asp Val Ala 
    210                 215                 220                 


Lys Pro Asp Leu Thr Ala Ala Leu Arg Glu Ile Arg Thr Gln Tyr Glu 
225                 230                 235                 240 


Ala Val Ala Thr Ser Asn Met Gln Glu Thr Glu Glu Trp Tyr Arg Ser 
                245                 250                 255     


Lys Phe Ala Asp Leu Thr Asp Ala Ala Ser Arg Asn Ala Glu Leu Leu 
            260                 265                 270         


Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln Leu Gln Ala 
        275                 280                 285             


Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu Ser Leu Glu 
    290                 295                 300                 


Arg Gln Met Arg Glu Gln Glu Glu Arg His Ala Arg Glu Ser Ala Ser 
305                 310                 315                 320 


Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln Ser Leu Lys 
                325                 330                 335     


Glu Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu Leu Asn Val 
            340                 345                 350         


Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu 
        355                 360                 365             


Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe Ser Asn Leu 
    370                 375                 380                 


Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser Glu Gly His 
385                 390                 395                 400 


Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg Asp Gly Glu 
                405                 410                 415     


Val Ile Lys Asp Ser Lys Gln Glu His Lys Asp Val Val Met 
            420                 425                 430 


<210>  15
<211>  430
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Met Glu Arg Arg Arg Ile Thr Ser Ala Arg Arg Ser Tyr Ala Ser Ser 
1               5                   10                  15      


Glu Thr Met Val Arg Gly His Gly Pro Thr Arg His Leu Gly Thr Ile 
            20                  25                  30          


Pro Arg Leu Ser Leu Ser Arg Met Thr Pro Pro Leu Pro Ala Arg Val 
        35                  40                  45              


Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu Thr Arg 
    50                  55                  60                  


Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe Ala Ser 
65                  70                  75                  80  


Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala Leu Ala 
                85                  90                  95      


Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu Ala Asp 
            100                 105                 110         


Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp Gln Leu 
        115                 120                 125             


Thr Thr Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu Thr Gln 
    130                 135                 140                 


Asp Leu Gly Thr Leu Arg Gln Lys Leu Gln Asp Glu Thr Asn Leu Arg 
145                 150                 155                 160 


Leu Glu Ala Glu Asn Asn Leu Ala Val Tyr Arg Gln Glu Ala Asp Glu 
                165                 170                 175     


Ala Thr Leu Ala Arg Val Asp Leu Glu Arg Lys Val Glu Ser Leu Glu 
            180                 185                 190         


Glu Glu Ile Gln Phe Leu Arg Lys Ile His Glu Glu Glu Val Arg Glu 
        195                 200                 205             


Leu Gln Glu Gln Leu Ala Gln Gln Gln Val His Val Glu Met Asp Val 
    210                 215                 220                 


Ala Lys Pro Asp Leu Thr Ala Ala Leu Arg Glu Ile Arg Thr Gln Tyr 
225                 230                 235                 240 


Glu Ala Val Ala Thr Ser Asn Met Gln Glu Thr Glu Glu Trp Tyr Arg 
                245                 250                 255     


Ser Lys Phe Ala Asp Leu Thr Asp Val Ala Ser Arg Asn Ala Glu Leu 
            260                 265                 270         


Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln Leu Gln 
        275                 280                 285             


Ala Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu Ser Leu 
    290                 295                 300                 


Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Ala Arg Glu Ser Ala 
305                 310                 315                 320 


Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln Ser Leu 
                325                 330                 335     


Lys Glu Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu Leu Asn 
            340                 345                 350         


Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu 
        355                 360                 365             


Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe Ser Asn 
    370                 375                 380                 


Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser Glu Gly 
385                 390                 395                 400 


His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg Asp Gly 
                405                 410                 415     


Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430 


<210>  16
<211>  422
<212>  PRT
<213>  Gallus gallus

<400>  16

Met Glu Ser Arg Arg Leu Ser Tyr Gly Arg Arg Phe Gly Pro Thr Gly 
1               5                   10                  15      


Ser Ala Trp Ser Pro Thr Glu Arg Pro Arg Pro Arg Gly Ala His Pro 
            20                  25                  30          


Ala Pro Arg Thr Ser Gly Arg Met Asp Phe Ser Leu Ala Asn Val Leu 
        35                  40                  45              


Asn Ser Glu Phe Arg Glu Thr Arg Thr Asn Glu Lys Val Glu Met Met 
    50                  55                  60                  


Glu Leu Asn Asp Arg Phe Ala Ser Tyr Ile Glu Lys Val Arg Leu Leu 
65                  70                  75                  80  


Glu Gln Arg Asn Lys Val Leu Val Leu Glu Leu Asn Arg Ala Arg Glu 
                85                  90                  95      


Gln Gln Pro Ser Arg Leu Gly Asp Val Tyr Gln Glu Glu Leu Arg Glu 
            100                 105                 110         


Leu Arg Arg Arg Val Glu Leu Leu Gly Thr Ala Lys Ala Arg Ala Glu 
        115                 120                 125             


Val Gln Arg Asp Gly Leu Ala Glu Glu Leu Gly Ser Leu Arg Glu Lys 
    130                 135                 140                 


Leu Gln Gln Glu Val Asn Leu Arg Leu Glu Ala Glu Ser Thr Leu Ala 
145                 150                 155                 160 


Ala Tyr Arg Gln Asp Val Asp Ala Ala Ala Leu Ala Arg Leu Asp Leu 
                165                 170                 175     


Glu Arg Arg Val Gly Ser Leu Gln Asp Glu Val Ala Phe Leu Gln Lys 
            180                 185                 190         


Val His Glu Glu Glu Leu Arg Glu Leu Gln Glu Gln Leu Ala Gln His 
        195                 200                 205             


Gln Val His Val Glu Val Asp Ala Ser Lys Pro Asp Leu Thr Ala Ala 
    210                 215                 220                 


Leu Arg Asp Ile Arg Thr Gln Tyr Glu Ala Met Ala Ala Ser Asn Met 
225                 230                 235                 240 


Gln Glu Thr Glu Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Thr Asp 
                245                 250                 255     


Ala Ala Ala Arg His Ala Glu Ala Leu Arg Ala Ala Lys His Glu Ala 
            260                 265                 270         


Asn Glu Tyr Arg Arg Gln Leu Gln Ala Leu Thr Cys Asp Leu Glu Ala 
        275                 280                 285             


Leu Arg Gly Ser Asn Glu Ser Leu Glu Arg Gln Leu Arg Glu Leu Glu 
    290                 295                 300                 


Glu Arg Tyr Ala Leu Glu Thr Ser Ala Tyr Gln Asp Thr Val Gly Arg 
305                 310                 315                 320 


Leu Glu Glu Asp Ile His Ser Leu Lys Glu Glu Met Gly Arg His Leu 
                325                 330                 335     


Gln Glu Tyr Gln Asp Leu Leu Asn Val Lys Leu Ala Leu Asp Ile Glu 
            340                 345                 350         


Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Thr 
        355                 360                 365             


Val Pro Val Gln Ser Phe Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu 
    370                 375                 380                 


Asp Thr Lys Ser Val Ser Glu Ala His Val Lys Arg Ser Ile Val Val 
385                 390                 395                 400 


Lys Thr Val Glu Thr Arg Asp Gly Glu Val Ile Lys Glu Ser Lys Gln 
                405                 410                 415     


Glu His Lys Glu Val Val 
            420         


<210>  17
<211>  444
<212>  PRT
<213>  Danio rerio

<400>  17

Met Glu Ser Gln Arg Ser Phe Ser Ser Tyr Arg Lys Arg Phe Gly Thr 
1               5                   10                  15      


Pro Gly Gly Ser Pro Ser Val Gly Val Thr Ser Arg His Ser Thr Gly 
            20                  25                  30          


Arg Leu Ser Leu His Ser Ser Pro Arg His Leu Thr Ser Ser Pro Leu 
        35                  40                  45              


Thr Leu Ser Thr Ser Arg Leu Ser Leu Gly Gly Glu Arg Leu Asp Phe 
    50                  55                  60                  


Ser Ala Asp Ser Leu Leu Lys Ala Gln Tyr Arg Glu Thr Arg Thr Asn 
65                  70                  75                  80  


Glu Lys Val Glu Met Met Gly Leu Asn Asp Arg Phe Ala Ser Tyr Ile 
                85                  90                  95      


Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Met Leu Val Ala Glu 
            100                 105                 110         


Leu Asn Gln Leu Arg Gly Lys Glu Pro Ser Arg Leu Gly Asp Ile Tyr 
        115                 120                 125             


Gln Glu Glu Leu Arg Glu Leu Arg Arg Gln Val Asp Gly Leu Asn Ala 
    130                 135                 140                 


Gly Lys Ala Arg Leu Glu Ile Glu Arg Asp Asn Leu Ala Ser Asp Leu 
145                 150                 155                 160 


Gly Thr Leu Lys Gln Arg Leu Gln Asp Glu Thr Ala Leu Arg Gln Glu 
                165                 170                 175     


Ala Glu Asn Asn Leu Asn Thr Phe Arg Gln Asp Val Asp Glu Ala Ala 
            180                 185                 190         


Leu Asn Arg Val Gln Leu Glu Arg Lys Ile Glu Ala Leu Gln Asp Glu 
        195                 200                 205             


Ile Asn Phe Leu Lys Lys Val His Glu Glu Glu Met Arg Glu Leu His 
    210                 215                 220                 


Glu Gln Leu Met Ala Gln Gln Val His Val Asp Leu Asp Val Ser Lys 
225                 230                 235                 240 


Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Ala Gln Phe Glu Ala 
                245                 250                 255     


Met Ala Asn Ser Asn Met Gln Glu Thr Glu Glu Trp Tyr Arg Ser Lys 
            260                 265                 270         


Phe Ala Asp Leu Thr Asp Ala Ala Asn Arg Asn Gly Glu Ala Leu Arg 
        275                 280                 285             


Gln Ala Lys Gln Glu Ala Asn Asp Tyr Arg Arg Gln Ile Gln Gly Leu 
    290                 295                 300                 


Thr Cys Asp Leu Glu Ser Leu Arg Gly Ser Asn Glu Ser Leu Glu Arg 
305                 310                 315                 320 


Gln Leu Lys Glu Met Glu Glu Arg Phe Ala Ile Glu Thr Ala Gly Tyr 
                325                 330                 335     


Gln Asp Thr Val Ala Arg Leu Glu Asp Glu Ile Gln Met Leu Lys Glu 
            340                 345                 350         


Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu Leu Asn Val Lys 
        355                 360                 365             


Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly 
    370                 375                 380                 


Glu Glu Ser Arg Ile Thr Val Pro Val Gln Asn Phe Thr Asn Leu Gln 
385                 390                 395                 400 


Phe Arg Asp Thr Ser Met Asp Thr Lys Leu Thr Pro Glu Ala His Val 
                405                 410                 415     


Lys Arg Ser Ile Val Val Arg Thr Val Glu Thr Arg Asp Gly Glu Ile 
            420                 425                 430         


Ile Lys Glu Ser Thr Thr Glu Arg Lys Asp Leu Pro 
        435                 440                 


