                               SEQUENCE LISTING	

<110> AGRAWAL, SUDHIR
      KANDIMALLA, EKAMBAR
      PUTTA, MALLIKARJUNA
      LAN, TAO
      BHAGAT, LAKSHMI
      WANG, DAQING
      YU, DONG
 
<120> COMPOSITIONS FOR INHIBITING GENE EXPRESSION AND USES THEREOF

<130> IDR-062

<140> 12/869,185
<141> 2010-08-26

<150> 61/240,553
<151> 2009-09-08

<150> 61/275,252
<151> 2009-08-27

<160> 177   

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 1
acagacttca ggaacagcca                                                   20


<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 2
acagacttca ggaacagcca                                                   20


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 3
acagacttca ggaacagcca                                                   20


<210> 4
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 4
acagacuuca ggaacagcca                                                   20


<210> 5
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 5
acagacuuca ggaacagcca                                                   20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (17)..(20)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 6
acagacttca ggaacagcca                                                   20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 7
acagacttca ggaacagcca                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphodiester internucleotide linkage

<400> 8
acagacttca ggaacagcca                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 9
acagacttca ggaacagcca                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 10
acagacttca ggaacagcca                                                   20


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 11
acagacttca ggaacagcca                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 12
acagacttca ggaacagcca                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 13
acagacttca ggaacagcca                                                   20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(7)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 14
acagacutca ggaacagcca                                                   20


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 15
acagacttca ggaacagcca                                                   20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (8)..(13)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 16
acagactuca ggaacagcca                                                   20


<210> 17
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<400> 17
acagacuuca gga                                                          13


<210> 18
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 18
acagacuuca ggaac                                                        15


<210> 19
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 19
cuugagguug agaugccgca                                                   20


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 20
aatgcttgtc tgtgcagtcc                                                   20


<210> 21
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 21
aaugcuuguc ugugcagucc                                                   20


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 22
acuuugaccu uugugugcu                                                    19


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 23
ccuggaguuu guugauguu                                                    19


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 24
ccagcagctc tagcagcctg                                                   20


<210> 25
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 25
ccagcagcuc uagcagccug                                                   20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 26
aatgcttgtc tgtgcagtcc                                                   20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 27
aatgcttgtc tgtgcagtcc                                                   20


<210> 28
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 28
ccugacgugu cuguucguaa                                                   20


<210> 29
<211> 31
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (25)..(26)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (26)..(27)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (27)..(28)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (28)..(29)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (28)..(31)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (29)..(30)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (30)..(31)
<223> Phosphorothioate internucleotide linkage

<400> 29
cugucaaaug cuugucugug caguccacga u                                      31


<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 30
acagacttca ggaacagcc                                                    19


<210> 31
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 31
acagacttca ggaacagcc                                                    19


<210> 32
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 32
acagacttca ggaacagcc                                                    19


<210> 33
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 33
aatgcttgtc tgtgcagtc                                                    19


<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 34
aatgcttgtc tgtgcagtc                                                    19


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 35
aatgcttgtc tgtgcagtcc                                                   20


<210> 36
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 36
cgcttgtgtc tccagttgc                                                    19


<210> 37
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 37
cgcttgtgtc tccagttgc                                                    19


<210> 38
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 38
cgcttgtgtc tccagttgc                                                    19


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 39
cacccaagac agcagaaag                                                    19


<210> 40
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 40
cacccaagac agcagaaag                                                    19


<210> 41
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 41
cacccaagac agcagaaag                                                    19


<210> 42
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 42
acagacttca ggaac                                                        15


<210> 43
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 43
acagacttca ggaacag                                                      17


<210> 44
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 44
acagacttca ggaacagcc                                                    19


<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphodiester internucleotide linkage

<400> 45
acagacttca ggaacagcca a                                                 21


<210> 46
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 46
acagacttca ggaacagcca att                                               23


<210> 47
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 47
acagacttca ggaacagcca attgc                                             25


<210> 48
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (25)..(26)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (26)..(27)
<223> Phosphorothioate internucleotide linkage

<400> 48
acagacttca ggaacagcca attgcag                                           27


<210> 49
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 49
acagacuuca ggaacagcca g                                                 21


<210> 50
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 50
acagacuuca ggaacagcca gtt                                               23


<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphodiester internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphodiester internucleotide linkage

<400> 51
acagacttca ggaacagcc                                                    19


<210> 52
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 52
acagacttca ggaacagcc                                                    19


<210> 53
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 53
acagacttca ggaacagcc                                                    19


<210> 54
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 54
acagacttca ggaacagcc                                                    19


<210> 55
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 55
acagacttca ggaacagcc                                                    19


<210> 56
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (16)..(19)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 56
acagacttca ggaacagcc                                                    19


<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 57
acagacttca ggaacagcc                                                    19


<210> 58
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 58
acagacttca ggaacagcc                                                    19


<210> 59
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<400> 59
acagacttc                                                                9


<210> 60
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (2)..(5)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (16)..(19)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 60
acagacttca ggaacagcc                                                    19


<210> 61
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 61
acagacttca ggaacagcca gtt                                               23


<210> 62
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 62
acagacttca ggaacagcc                                                    19


<210> 63
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 63
aatgcttgtc tgtgcag                                                      17


<210> 64
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 64
aatgcttgtc tgtgcagtc                                                    19


<210> 65
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 65
aatgcttgtc tgtgcagtcc a                                                 21


<210> 66
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 66
ccagcagctc tagca                                                        15


<210> 67
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 67
ccagcagctc tagcagc                                                      17


<210> 68
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 68
ccagcagctc tagcagcct                                                    19


<210> 69
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 69
ccagcagctc tagcagcctg c                                                 21


<210> 70
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 70
ccagcagctc tagcagcctg ccg                                               23


<210> 71
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 71
ccagcagctc tagcagcctg ccgac                                             25


<210> 72
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 72
cgcttgtgtc tccag                                                        15


<210> 73
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 73
cgcttgtgtc tccagtt                                                      17


<210> 74
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 74
cgcttgtgtc tccagttgc                                                    19


<210> 75
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 75
cgcttgtgtc tccagttgcc g                                                 21


<210> 76
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 76
cgcttgtgtc tccagttgcc gga                                               23


<210> 77
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 77
cgcttgtgtc tccagttgcc ggatc                                             25


<210> 78
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (16)..(19)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 78
ccagcagctc tagcagccu                                                    19


<210> 79
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (16)..(19)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 79
cgcutgtgtc tccaguugc                                                    19


<210> 80
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 80
cgcttgtgtc tccagttgc                                                    19


<210> 81
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 81
cgcttgtgtc tccagttgc                                                    19


<210> 82
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 82
gcagttcttg gaggttc                                                      17


<210> 83
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 83
gcagttcttg gaggttctc                                                    19


<210> 84
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 84
gcagttcttg gaggttctcc a                                                 21


<210> 85
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 85
cttccatgtt aaggtgc                                                      17


<210> 86
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 86
cttccatgtt aaggtgctc                                                    19


<210> 87
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 87
cttccatgtt aaggtgctcc a                                                 21


<210> 88
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 88
cacccaagac agcagaaag                                                    19


<210> 89
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 89
gacacctgtt ctcac                                                        15


<210> 90
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 90
gacacctgtt ctcactc                                                      17


<210> 91
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 91
gacacctgtt ctcactcac                                                    19


<210> 92
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 92
gacacctgtt ctcactcaca g                                                 21


<210> 93
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 93
gacacctgtt ctcactcaca gat                                               23


<210> 94
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 94
gacacctgtt ctcactcac                                                    19


<210> 95
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<400> 95
gacacctgt                                                                9


<210> 96
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 96
gtacttcatc actatctcc                                                    19


<210> 97
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 97
cttggctctt tctctgtcc                                                    19


<210> 98
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 98
tatgatctgt cacagcttg                                                    19


<210> 99
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 99
gctaggtttc ctccctttc                                                    19


<210> 100
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 100
gtggatcagt ctctgcctc                                                    19


<210> 101
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 101
tacacctcca ccaggctgc                                                    19


<210> 102
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 102
gtggatcagt ctctgcctc                                                    19


<210> 103
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 103
cttgactttg cattccaga                                                    19


<210> 104
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<400> 104
tacacctcc                                                                9


<210> 105
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<400> 105
gtggatcag                                                                9


<210> 106
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<400> 106
cttgacttt                                                                9


<210> 107
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 107
actttgcatt ccaga                                                        15


<210> 108
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 108
tgactttgca ttccaga                                                      17


<210> 109
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 109
cttgactttg cattccaga                                                    19


<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 110
tccttgactt tgcattccag a                                                 21


<210> 111
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 111
gctccttgac tttgcattcc aga                                               23


<210> 112
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 112
atgctccttg actttgcatt ccaga                                             25


<210> 113
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 113
cctccaccag gctgc                                                        15


<210> 114
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 114
cacctccacc aggctgc                                                      17


<210> 115
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 115
tacacctcca ccaggctgc                                                    19


<210> 116
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 116
gatacacctc caccaggctg c                                                 21


<210> 117
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 117
gagatacacc tccaccaggc tgc                                               23


<210> 118
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 118
aggagataca cctccaccag gctgc                                             25


<210> 119
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 119
tgacctgctc tgaaggacc                                                    19


<210> 120
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 120
acagacuuca ggaacag                                                      17


<210> 121
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 121
acagacuuca ggaacagcc                                                    19


<210> 122
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 122
acagacuuca ggaacagcca a                                                 21


<210> 123
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 123
acagacuuca ggaacagcca auu                                               23


<210> 124
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 124
acagacuuca ggaacagcca auugc                                             25


<210> 125
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (25)..(26)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (26)..(27)
<223> Phosphorothioate internucleotide linkage

<400> 125
acagacuuca ggaacagcca auugcag                                           27


<210> 126
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 126
acagacuuca ggaacagcca g                                                 21


<210> 127
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 127
acagacuuca ggaacagcca guu                                               23


<210> 128
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 128
acagacuuca ggaacagcca guugc                                             25


<210> 129
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 129
acagacuuca ggaacagcca                                                   20


<210> 130
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 130
acagacuuca ggaacagcca                                                   20


<210> 131
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 131
acagacuuca ggaacagcca                                                   20


<210> 132
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 132
acagacuuca ggaacagcca                                                   20


<210> 133
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 133
acagacuuca ggaacagcca                                                   20


<210> 134
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 134
acagacuuca ggaacagcca                                                   20


<210> 135
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 135
acagacuuca ggaacagcca                                                   20


<210> 136
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 136
acagacuuca ggaacagcca                                                   20


<210> 137
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 137
acagacuuca ggaacagcca                                                   20


<210> 138
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(20)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<400> 138
acagacuuca ggaacagcca                                                   20


<210> 139
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe nucleotide 

<400> 139
acagacuuca ggaacagcca a                                                 21


<210> 140
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe nucleotide 

<400> 140
acagacuuca ggaacagcca a                                                 21


<210> 141
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-OMe nucleotide

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 141
acagacuuca ggaacagcca a                                                 21


<210> 142
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-OMe nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 142
acagacuuca ggaacagcca a                                                 21


<210> 143

<400> 143
000 


<210> 144
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 144
ccagcagcuc uagca                                                        15


<210> 145
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 145
ccagcagcuc uagcagc                                                      17


<210> 146
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 146
ccagcagcuc uagcagccu                                                    19


<210> 147
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 147
ccagcagcuc uagcagccug c                                                 21


<210> 148
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 148
ccagcagcuc uagcagccug ccg                                               23


<210> 149
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 149
ccagcagcuc uagcagccug ccgac                                             25


<210> 150
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 150
cgcuuguguc uccag                                                        15


<210> 151
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 151
cgcuuguguc uccaguu                                                      17


<210> 152
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 152
cgcuuguguc uccaguugc                                                    19


<210> 153
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 153
cgcuuguguc uccaguugcc g                                                 21


<210> 154
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 154
cgcuuguguc uccaguugcc gga                                               23


<210> 155
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 155
cgcuuguguc uccaguugcc ggauc                                             25


<210> 156
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<400> 156
aaugcuuguc ugugc                                                        15


<210> 157
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 157
aaugcuuguc ugugcag                                                      17


<210> 158
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 158
aaugcuuguc ugugcaguc                                                    19


<210> 159
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 159
aaugcuuguc ugugcagucc a                                                 21


<210> 160
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<400> 160
aaugcuuguc ugugcagucc acg                                               23


<210> 161
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (21)..(22)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (23)..(24)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (24)..(25)
<223> Phosphorothioate internucleotide linkage

<400> 161
aaugcuuguc ugugcagucc acgau                                             25


<210> 162

<400> 162
000


<210> 163
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 163
gcaguucuug gagguuc                                                      17


<210> 164
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 164
gcaguucuug gagguucuc                                                    19


<210> 165
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 165
gcaguucuug gagguucucc a                                                 21


<210> 166
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 166
gcucaauagc uugcugaac                                                    19


<210> 167
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 167
cuuccauguu aaggugc                                                      17


<210> 168
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 168
cuuccauguu aaggugcuc                                                    19


<210> 169
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 169
cuuccauguu aaggugcucc a                                                 21


<210> 170
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 170
guuggcuaug uuguuguug                                                    19


<210> 171
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<400> 171
ugacaccugu ucucacu                                                      17


<210> 172
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 172
ugacaccugu ucucacuca                                                    19


<210> 173
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate internucleotide linkage

<400> 173
ugacaccugu ucucacucac a                                                 21


<210> 174
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 174
gaucacuccc accuucagg                                                    19


<210> 175
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate internucleotide linkage

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate internucleotide linkage

<400> 175
gaaagacgac agaacccac                                                    19


<210> 176
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 176
augugaucgu ggacugcaca gacaagcauu ugacagaau                              39


<210> 177
<211> 40
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 177
aaugcuuguc ugugcagucc aaugcuuguc ugugcagucc                             40                                   

