                         SEQUENCE LISTING

<110>  Max-Planck-Gesellschaft zur Frderung der Wissenschaften 
       e.V.
 
<120>  Kinases labeled in the C helix for the screening of inhibitors

<130>  T1082 PCT

<150>  EP 11 00 2746.3
<151>  2011-04-01

<150>  US 61/470,596
<151>  2011-04-01

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Gly Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys 
1               5                   10                  15      


Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu 
            20                  25                  30          


Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu 
        35                  40                  45              


Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Cys Ile Leu Asp Glu 
    50                  55                  60                  


Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu 
65                  70                  75                  80  


Gly Ile Ser Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro 
                85                  90                  95      


Phe Gly Ser Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly 
            100                 105                 110         


Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn 
        115                 120                 125             


Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
    130                 135                 140                 


Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly 
                165                 170                 175     


Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile 
            180                 185                 190         


Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu 
        195                 200                 205             


Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu 
    210                 215                 220                 


Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
225                 230                 235                 240 


Ser Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp 
                245                 250                 255     


Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys 
            260                 265                 270         


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg 
        275                 280                 285             


Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met 
    290                 295                 300                 


Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr 
305                 310                 315             


<210>  2
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210>  3
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  4
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  5
<211>  1146
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Leu Gly Thr Val Leu Leu Pro Pro Asn Ser Tyr Gly Arg Asp 
1               5                   10                  15      


Gln Asp Thr Ser Leu Cys Cys Leu Cys Thr Glu Ala Ser Glu Ser Ala 
            20                  25                  30          


Leu Pro Asp Leu Thr Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val 
        35                  40                  45              


Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn 
    50                  55                  60                  


Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr 
65                  70                  75                  80  


Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu 
                85                  90                  95      


Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val 
            100                 105                 110         


Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Thr Pro 
        115                 120                 125             


Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg 
    130                 135                 140                 


Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu 
145                 150                 155                 160 


Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg 
                165                 170                 175     


Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr Thr Ala Asp Gly 
            180                 185                 190         


Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr Leu Ala Glu Leu 
        195                 200                 205             


Val His His His Ser Thr Val Ala Asp Gly Leu Val Thr Thr Leu His 
    210                 215                 220                 


Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr Gly Val Ser Pro 
225                 230                 235                 240 


Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met Lys His 
                245                 250                 255     


Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys 
            260                 265                 270         


Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp Thr Met 
        275                 280                 285             


Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys 
    290                 295                 300                 


His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr Leu Glu Pro Pro 
305                 310                 315                 320 


Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr 
                325                 330                 335     


Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val Val Leu Leu Tyr 
            340                 345                 350         


Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn 
        355                 360                 365             


Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn 
    370                 375                 380                 


His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Thr Gly 
385                 390                 395                 400 


Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Thr 
                405                 410                 415     


Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile Lys Ser Asp Val 
            420                 425                 430         


Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly Met Ser 
        435                 440                 445             


Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys 
    450                 455                 460                 


Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu 
465                 470                 475                 480 


Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe 
                485                 490                 495     


Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His Asp Ser Ser Ile 
            500                 505                 510         


Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala Ser Ser Ser Ser 
        515                 520                 525             


Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro Ser Lys Thr Arg 
    530                 535                 540                 


Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile Glu Gly Ala Gln 
545                 550                 555                 560 


Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro Gly Phe Ile Arg 
                565                 570                 575     


Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro Arg Lys Gln Arg 
            580                 585                 590         


Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys Glu Thr Cys Phe 
        595                 600                 605             


Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe Met Lys Lys Arg 
    610                 615                 620                 


Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met Glu 
625                 630                 635                 640 


Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn Phe Ser Ser Val 
                645                 650                 655     


Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr Pro Ala Gln Gln 
            660                 665                 670         


Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly Ser Phe Ala Gln 
        675                 680                 685             


Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly Gly Ser Gly Thr 
    690                 695                 700                 


Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe Thr Pro Arg Leu 
705                 710                 715                 720 


Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro Thr Ala Ser Asp 
                725                 730                 735     


Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr Ser Ser Met Ser 
            740                 745                 750         


Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr Leu Pro Arg Asn 
        755                 760                 765             


Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val Ser Thr Ser Ser 
    770                 775                 780                 


Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys 
785                 790                 795                 800 


Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu 
                805                 810                 815     


Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr Pro Ser Gly Asp 
            820                 825                 830         


Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val 
        835                 840                 845             


Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly 
    850                 855                 860                 


Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro 
865                 870                 875                 880 


Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn His Lys Val Pro 
                885                 890                 895     


Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala Asp Val Gln Leu 
            900                 905                 910         


Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His 
        915                 920                 925             


Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro 
    930                 935                 940                 


Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro 
945                 950                 955                 960 


Ser Ile Cys Ser Asp Pro Thr Glu Glu Pro Thr Ala Leu Thr Ala Gly 
                965                 970                 975     


Gln Ser Thr Ser Glu Thr Gln Glu Gly Gly Lys Lys Ala Ala Leu Gly 
            980                 985                 990         


Ala Val Pro Ile Ser Gly Lys Ala  Gly Arg Pro Val Met  Pro Pro Pro 
        995                 1000                 1005             


Gln Val  Pro Leu Pro Thr Ser  Ser Ile Ser Pro Ala  Lys Met Ala 
    1010                 1015                 1020             


Asn Gly  Thr Ala Gly Thr Lys  Val Ala Leu Arg Lys  Thr Lys Gln 
    1025                 1030                 1035             


Ala Ala  Glu Lys Ile Ser Ala  Asp Lys Ile Ser Lys  Glu Ala Leu 
    1040                 1045                 1050             


Leu Glu  Cys Ala Asp Leu Leu  Ser Ser Ala Leu Thr  Glu Pro Val 
    1055                 1060                 1065             


Pro Asn  Ser Gln Leu Val Asp  Thr Gly His Gln Leu  Leu Asp Tyr 
    1070                 1075                 1080             


Cys Ser  Gly Tyr Val Asp Cys  Ile Pro Gln Thr Arg  Asn Lys Phe 
    1085                 1090                 1095             


Ala Phe  Arg Glu Ala Val Ser  Lys Leu Glu Leu Ser  Leu Gln Glu 
    1100                 1105                 1110             


Leu Gln  Val Ser Ser Ala Ala  Ala Gly Val Pro Gly  Thr Asn Pro 
    1115                 1120                 1125             


Val Leu  Asn Asn Leu Leu Ser  Cys Val Gln Glu Ile  Ser Asp Val 
    1130                 1135                 1140             


Val Gln  Arg 
    1145     


<210>  6
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Tyr Asp Phe Lys Ala Lys Leu Ala Ala Glu Arg Glu Arg Val 
1               5                   10                  15      


Glu Asp Leu Phe Glu Tyr Glu Gly Cys Lys Val Gly Arg Gly Thr Tyr 
            20                  25                  30          


Gly His Val Tyr Lys Ala Arg Arg Lys Asp Gly Lys Asp Glu Lys Glu 
        35                  40                  45              


Tyr Ala Leu Lys Gln Ile Glu Gly Thr Gly Ile Ser Met Ser Ala Cys 
    50                  55                  60                  


Arg Glu Ile Ala Leu Leu Arg Glu Leu Lys His Pro Asn Val Ile Ala 
65                  70                  75                  80  


Leu Gln Lys Val Phe Leu Ser His Ser Asp Arg Lys Val Trp Leu Leu 
                85                  90                  95      


Phe Asp Tyr Ala Glu His Asp Leu Trp His Ile Ile Lys Phe His Arg 
            100                 105                 110         


Ala Ser Lys Ala Asn Lys Lys Pro Met Gln Leu Pro Arg Ser Met Val 
        115                 120                 125             


Lys Ser Leu Leu Tyr Gln Ile Leu Asp Gly Ile His Tyr Leu His Ala 
    130                 135                 140                 


Asn Trp Val Leu His Arg Asp Leu Lys Pro Ala Asn Ile Leu Val Met 
145                 150                 155                 160 


Gly Glu Gly Pro Glu Arg Gly Arg Val Lys Ile Ala Asp Met Gly Phe 
                165                 170                 175     


Ala Arg Leu Phe Asn Ser Pro Leu Lys Pro Leu Ala Asp Leu Asp Pro 
            180                 185                 190         


Val Val Val Thr Phe Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly Ala 
        195                 200                 205             


Arg His Tyr Thr Lys Ala Ile Asp Ile Trp Ala Ile Gly Cys Ile Phe 
    210                 215                 220                 


Ala Glu Leu Leu Thr Ser Glu Pro Ile Phe His Cys Arg Gln Glu Asp 
225                 230                 235                 240 


Ile Lys Thr Ser Asn Pro Phe His His Asp Gln Leu Asp Arg Ile Phe 
                245                 250                 255     


Ser Val Met Gly Phe Pro Ala Asp Lys Asp Trp Glu Asp Ile Arg Lys 
            260                 265                 270         


Met Pro Glu Tyr Pro Thr Leu Gln Lys Asp Phe Arg Arg Thr Thr Tyr 
        275                 280                 285             


Ala Asn Ser Ser Leu Ile Lys Tyr Met Glu Lys His Lys Val Lys Pro 
    290                 295                 300                 


Asp Ser Lys Val Phe Leu Leu Leu Gln Lys Leu Leu Thr Met Asp Pro 
305                 310                 315                 320 


Thr Lys Arg Ile Thr Ser Glu Gln Ala Leu Gln Asp Pro Tyr Phe Gln 
                325                 330                 335     


Glu Asp Pro Leu Pro Thr Leu Asp Val Phe Ala Gly Cys Gln Ile Pro 
            340                 345                 350         


Tyr Pro Lys Arg Glu Phe Leu Asn Glu Asp Asp Pro Glu Glu Lys Gly 
        355                 360                 365             


Asp Lys Asn Gln Gln Gln Gln Gln Asn Gln His Gln Gln Pro Thr Ala 
    370                 375                 380                 


Pro Pro Gln Gln Ala Ala Ala Pro Pro Gln Ala Pro Pro Pro Gln Gln 
385                 390                 395                 400 


Asn Ser Thr Gln Thr Asn Gly Thr Ala Gly Gly Ala Gly Ala Gly Val 
                405                 410                 415     


Gly Gly Thr Gly Ala Gly Leu Gln His Ser Gln Asp Ser Ser Leu Asn 
            420                 425                 430         


Gln Val Pro Pro Asn Lys Lys Pro Arg Leu Gly Pro Ser Gly Ala Asn 
        435                 440                 445             


Ser Gly Gly Pro Val Met Pro Ser Asp Tyr Gln His Ser Ser Ser Arg 
    450                 455                 460                 


Leu Asn Tyr Gln Ser Ser Val Gln Gly Ser Ser Gln Ser Gln Ser Thr 
465                 470                 475                 480 


Leu Gly Tyr Ser Ser Ser Ser Gln Gln Ser Ser Gln Tyr His Pro Ser 
                485                 490                 495     


His Gln 
        


<210>  7
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Thr Glu Thr Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 
    50                  55                  60                  


Lys Leu Leu Asp Val Ile His Thr Glu Asn Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 
                85                  90                  95      


Thr Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Thr Glu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Thr Tyr Thr 
145                 150                 155                 160 


His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Cys Lys Tyr Tyr Ser Thr Ala Val Asp Ile Trp Ser Leu Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Thr Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Thr Leu Gly Thr Pro Asp Glu 
    210                 215                 220                 


Val Val Trp Pro Gly Val Thr Ser Met Pro Asp Tyr Lys Pro Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp 
                245                 250                 255     


Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn 
            260                 265                 270         


Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp 
        275                 280                 285             


Val Thr Lys Pro Val Pro His Leu Arg Leu 
    290                 295             


<210>  8
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Met Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Lys Asn Arg Glu Thr Gly Gln Leu Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Leu Glu Met Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Lys His Pro Asn Ile Val 
    50                  55                  60                  


Arg Leu Leu Asp Val Val His Asn Glu Arg Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Gln Asp Leu Lys Lys Tyr Met Asp Ser Thr Pro Gly 
                85                  90                  95      


Ser Glu Leu Pro Leu His Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Val Ser Phe Cys His Ser His Arg Val Ile His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Glu Leu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Leu Arg Thr Tyr Thr 
145                 150                 155                 160 


His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Ser Lys Phe Tyr Thr Thr Ala Val Asp Ile Trp Ser Ile Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Thr Arg Lys Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Met Leu Gly Thr Pro Ser Glu 
    210                 215                 220                 


Asp Thr Trp Pro Gly Val Thr Gln Leu Pro Asp Tyr Lys Gly Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Thr Arg Lys Gly Leu Glu Glu Ile Val Pro Asn Leu Glu 
                245                 250                 255     


Pro Glu Gly Arg Asp Leu Leu Met Gln Leu Leu Gln Tyr Asp Pro Ser 
            260                 265                 270         


Gln Arg Ile Thr Ala Lys Thr Ala Leu Ala His Pro Tyr Phe Ser Ser 
        275                 280                 285             


Pro Glu Pro Ser Pro Ala Ala Arg Gln Tyr Val Leu Gln Arg Phe Arg 
    290                 295                 300                 


His 
305 


<210>  9
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Ser Phe Leu Phe Gln Leu Leu Lys 
            100                 105                 110         


Gly Leu Gly Phe Cys His Ser Arg Asn Val Leu His Arg Asp Leu Lys 
        115                 120                 125             


Pro Gln Asn Leu Leu Ile Asn Arg Asn Gly Glu Leu Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
145                 150                 155                 160 


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
                165                 170                 175     


Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
            180                 185                 190         


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
        195                 200                 205             


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu 
    210                 215                 220                 


Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
225                 230                 235                 240 


Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn 
                245                 250                 255     


Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
            260                 265                 270         


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
        275                 280                 285             


Phe Cys Pro Pro 
    290         


<210>  10
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  11
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Cys Lys Val Gly Arg Gly Thr Tyr Gly His Val Tyr Lys Ala Lys 
1               5                   10                  15      


Arg Lys Asp Gly Lys Asp Asp Lys Asp Tyr Ala Leu Lys Gln Ile Glu 
            20                  25                  30          


Gly Thr Gly Ile Ser Met Ser Ala Cys Arg Glu Ile Ala Leu Leu Arg 
        35                  40                  45              


Glu Leu Lys His Pro Asn Val Ile Ser Leu Gln Lys Val Phe Leu Ser 
    50                  55                  60                  


His Ala Asp Arg Lys Val Trp Leu Leu Phe Asp Tyr Ala Glu His Asp 
65                  70                  75                  80  


Leu Trp His Ile Ile Lys Phe His Arg Ala Ser Lys Ala Asn Lys Lys 
                85                  90                  95      


Pro Val Gln Leu Pro Arg Gly Met Val Lys Ser Leu Leu Tyr Gln Ile 
            100                 105                 110         


Leu Asp Gly Ile His Tyr Leu His Ala Asn Trp Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Ala Asn Ile Leu Val Met Gly Glu Gly Pro Glu Arg Gly 
    130                 135                 140                 


Arg Val Lys Ile Ala Asp Met Gly Phe Ala Arg Leu Phe Asn Ser Pro 
145                 150                 155                 160 


Leu Lys Pro Leu Ala Asp Leu Asp Pro Val Val Val Thr Phe Trp Tyr 
                165                 170                 175     


Arg Ala Pro Glu Leu Leu Leu Gly Ala Arg His Tyr Thr Lys Ala Ile 
            180                 185                 190         


Asp Ile Trp Ala Ile Gly Cys Ile Phe Ala Glu Leu Leu Thr Ser Glu 
        195                 200                 205             


Pro Ile Phe His Cys Arg Gln Glu Asp Ile Lys Thr Ser Asn Pro Tyr 
    210                 215                 220                 


His His Asp Gln Leu Asp Arg Ile Phe Asn Val Met Gly Phe Pro Ala 
225                 230                 235                 240 


Asp Lys Asp Trp Glu Asp Ile Lys Lys Met Pro Glu His Ser Thr Leu 
                245                 250                 255     


Met Lys Asp Phe Arg Arg Asn Thr Tyr Thr Asn Cys Ser Leu Ile Lys 
            260                 265                 270         


Tyr Met Glu Lys His Lys Val Lys Pro Asp Ser Lys Ala Phe His Leu 
        275                 280                 285             


Leu Gln Lys Leu Leu Thr Met Asp Pro Ile Lys Arg Ile Thr Ser Glu 
    290                 295                 300                 


Gln Ala Met Gln Asp Pro Tyr Phe 
305                 310         


<210>  12
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Lys Gln Tyr Asp Ser Val Glu Cys Pro Phe Cys Asp Glu Val 
1               5                   10                  15      


Ser Lys Tyr Glu Lys Leu Ala Lys Ile Gly Gln Gly Thr Phe Gly Glu 
            20                  25                  30          


Val Phe Lys Ala Arg His Arg Lys Thr Gly Gln Lys Val Ala Leu Lys 
        35                  40                  45              


Lys Val Leu Met Glu Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Leu 
    50                  55                  60                  


Arg Glu Ile Lys Ile Leu Gln Leu Leu Lys His Glu Asn Val Val Asn 
65                  70                  75                  80  


Leu Ile Glu Ile Cys Arg Thr Lys Ala Ser Pro Tyr Asn Arg Cys Lys 
                85                  90                  95      


Gly Ser Ile Tyr Leu Val Phe Asp Phe Cys Glu His Asp Leu Ala Gly 
            100                 105                 110         


Leu Leu Ser Asn Val Leu Val Lys Phe Thr Leu Ser Glu Ile Lys Arg 
        115                 120                 125             


Val Met Gln Met Leu Leu Asn Gly Leu Tyr Tyr Ile His Arg Asn Lys 
    130                 135                 140                 


Ile Leu His Arg Asp Met Lys Ala Ala Asn Val Leu Ile Thr Arg Asp 
145                 150                 155                 160 


Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Phe Ser Leu 
                165                 170                 175     


Ala Lys Asn Ser Gln Pro Asn Arg Tyr Thr Asn Arg Val Val Thr Leu 
            180                 185                 190         


Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Arg Asp Tyr Gly Pro 
        195                 200                 205             


Pro Ile Asp Leu Trp Gly Ala Gly Cys Ile Met Ala Glu Met Trp Thr 
    210                 215                 220                 


Arg Ser Pro Ile Met Gln Gly Asn Thr Glu Gln His Gln Leu Ala Leu 
225                 230                 235                 240 


Ile Ser Gln Leu Cys Gly Ser Ile Thr Pro Glu Val Trp Pro Asn Val 
                245                 250                 255     


Asp Asn Tyr Glu Leu Tyr Glu Lys Leu Glu Leu Val Lys Gly Gln Lys 
            260                 265                 270         


Arg Lys Val Lys Asp Arg Leu Lys Ala Tyr Val Arg Asp Pro Tyr Ala 
        275                 280                 285             


Leu Asp Leu Ile Asp Lys Leu Leu Val Leu Asp Pro Ala Gln Arg Ile 
    290                 295                 300                 


Asp Ser Asp Asp Ala Leu Asn His Asp Phe Phe Trp Ser Asp Pro Met 
305                 310                 315                 320 


Pro Ser Asp Leu Lys Gly Met Leu Ser Thr His Leu Thr Ser Met Phe 
                325                 330                 335     


Glu Tyr Leu Ala Pro Pro Arg Arg Lys Gly Ser Gln Ile Thr Gln Gln 
            340                 345                 350         


Ser Thr Asn Gln Ser Arg Asn Pro Ala Thr Thr Asn Gln Thr Glu Phe 
        355                 360                 365             


Glu Arg Val Phe 
    370         


