                         SEQUENCE LISTING

<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) 
       Paris
       INSTITUT PASTEUR DE LILLE
 
<120>  Utilisation de l'epigallocatechine gallate comme agent antiviral 
       contre les infections par le virus de l'hpatite C

<130>  BET 12P0431

<150>  FR 11 52536
<151>  2011-03-28

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  192
<212>  PRT
<213>  Hepatitis C virus Type 1a

<400>  1

Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys 
1               5                   10                  15      


Pro Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr 
            20                  25                  30          


Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp 
        35                  40                  45              


Val Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr 
    50                  55                  60                  


Thr Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu 
65                  70                  75                  80  


Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val 
                85                  90                  95      


Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp 
            100                 105                 110         


Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala 
        115                 120                 125             


Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala 
    130                 135                 140                 


Gln Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala Gly Ala 
145                 150                 155                 160 


His Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn 
                165                 170                 175     


Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala 
            180                 185                 190         


<210>  2
<211>  363
<212>  PRT
<213>  Hepatitis C virus Type 1a

<400>  2

Glu Thr His Val Thr Gly Gly Ser Ala Gly His Thr Thr Ala Gly Leu 
1               5                   10                  15      


Val Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Thr Thr Gly Trp Leu Ala Gly Leu Phe Tyr Arg His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr 
65                  70                  75                  80  


Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly 
                85                  90                  95      


Leu Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly 
            180                 185                 190         


Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys 
    210                 215                 220                 


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn 
225                 230                 235                 240 


Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln 
        275                 280                 285             


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu 
            340                 345                 350         


Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
        355                 360             


<210>  3
<211>  214
<212>  PRT
<213>  Hepatitis C virus Type 1b

<400>  3

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Ile Pro Ala Ser Ala Tyr Glu Val Arg Asn Val Ser Gly Val Tyr 
            20                  25                  30          


His Val Thr Asn Asp Cys Ser Asn Ala Ser Ile Val Tyr Glu Ala Ala 
        35                  40                  45              


Asp Met Ile Met His Thr Pro Gly Cys Val Pro Cys Val Arg Glu Asn 
    50                  55                  60                  


Asn Phe Ser Arg Cys Trp Val Ala Leu Thr Pro Thr Leu Ala Ala Arg 
65                  70                  75                  80  


Asn Thr Ser Val Pro Thr Thr Thr Ile Arg Arg His Val Asp Leu Leu 
                85                  90                  95      


Val Gly Ala Ala Ala Phe Cys Ser Ala Met Tyr Val Gly Asp Leu Cys 
            100                 105                 110         


Gly Ser Val Phe Leu Val Ser Gln Leu Phe Thr Phe Ser Pro Arg Arg 
        115                 120                 125             


His Glu Thr Val Gln Asp Cys Asn Cys Ser Ile Phe Pro Gly Pro Val 
    130                 135                 140                 


Thr Gly His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr 
145                 150                 155                 160 


Thr Ala Ile Val Val Ser Gln Leu Leu Arg Ile Pro Gln Ala Val Val 
                165                 170                 175     


Asp Met Val Ala Gly Ala His Trp Gly Val Leu Ala Gly Leu Ala Tyr 
            180                 185                 190         


Tyr Ser Met Val Gly Asn Trp Ala Lys Val Leu Ile Val Met Leu Leu 
        195                 200                 205             


Phe Ala Gly Val Asp Gly 
    210                 


<210>  4
<211>  363
<212>  PRT
<213>  Hepatitis C virus Type 1b

<400>  4

Glu Thr His Val Thr Gly Gly Lys Gln Ser Arg Asp Thr His Gly Phe 
1               5                   10                  15      


Val Ser Leu Phe Thr Leu Gly Pro Ser Gln Lys Ile Gln Leu Val Asn 
            20                  25                  30          


Ser Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Arg Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Arg Arg Ile Asp 
65                  70                  75                  80  


Ala Phe Ala Gln Gly Ser Gly Pro Ile Thr Tyr Thr Glu Pro Asp Ser 
                85                  90                  95      


Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Ser Lys Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Val Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Gly Gly Val Gly 
            180                 185                 190         


Asn Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
    210                 215                 220                 


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
225                 230                 235                 240 


Phe Thr Ile Phe Lys Val Arg Met Tyr Leu Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys His Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu 
        275                 280                 285             


Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Ile Gly Ser Ala Val Val Ser Phe Val Ile Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu 
            340                 345                 350         


Trp Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
        355                 360             


<210>  5
<211>  189
<212>  PRT
<213>  Hepatitis C virus Type 2a

<400>  5

Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn His Cys Pro Asn 
1               5                   10                  15      


Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro Gly 
            20                  25                  30          


Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val Ala 
        35                  40                  45              


Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr Gln 
    50                  55                  60                  


Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys Ser 
65                  70                  75                  80  


Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly Gln 
                85                  90                  95      


Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn 
            100                 105                 110         


Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp 
        115                 120                 125             


Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln Leu 
    130                 135                 140                 


Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His Trp 
145                 150                 155                 160 


Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp Ala 
                165                 170                 175     


Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp 
            180                 185                 


<210>  6
<211>  344
<212>  PRT
<213>  Hepatitis C virus Type 2a

<400>  6

Tyr Val Thr Gly Gly Ala Ala Ala Lys Gly Ala Ser Thr Phe Ala Gly 
1               5                   10                  15      


Leu Phe Ala Pro Gly Ser Arg Gln Asn Ile Gln Leu Ile Asn Thr Asn 
            20                  25                  30          


Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser Leu 
        35                  40                  45              


Glu Thr Gly Trp Leu Val Gly Leu Phe Tyr Tyr Asn Lys Phe Asn Ser 
    50                  55                  60                  


Ser Gly Cys Thr Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp Phe 
65                  70                  75                  80  


Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Asn Gly Ser Gly Pro Glu 
                85                  90                  95      


His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile Val 
            100                 105                 110         


Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro 
        115                 120                 125             


Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn Trp 
    130                 135                 140                 


Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro Pro 
145                 150                 155                 160 


Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe Thr 
                165                 170                 175     


Lys Val Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly Asn Asn 
            180                 185                 190         


Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr 
        195                 200                 205             


Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu Val 
    210                 215                 220                 


Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Leu Asn Tyr Thr 
225                 230                 235                 240 


Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Gly 
                245                 250                 255     


Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp Arg 
            260                 265                 270         


Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp Gln 
        275                 280                 285             


Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly Leu 
    290                 295                 300                 


Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val 
305                 310                 315                 320 


Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile Leu 
                325                 330                 335     


Leu Phe Leu Leu Leu Ala Asp Ala 
            340                 


<210>  7
<211>  214
<212>  PRT
<213>  Hepatitis C virus Type 2b

<400>  7

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Val Pro Ala Ser Ala Val Glu Val Arg Asn Val Ser Ser Ser Tyr 
            20                  25                  30          


Tyr Ala Thr Asn Asp Cys Ser Asn Ser Ser Ile Thr Trp Gln Leu Asn 
        35                  40                  45              


Asn Ala Val Leu His Leu Pro Gly Cys Val Pro Cys Glu Asn Asp Asn 
    50                  55                  60                  


Gly Thr Leu His Cys Trp Ile Gln Val Thr Pro Asn Val Ala Val Lys 
65                  70                  75                  80  


His Arg Gly Ala Leu Thr His Asn Leu Arg Thr His Val Asp Met Ile 
                85                  90                  95      


Val Met Ala Ala Thr Val Cys Ser Ala Leu Tyr Val Gly Asp Met Cys 
            100                 105                 110         


Gly Ala Val Met Ile Val Ser Gln Ala Leu Ile Ile Ser Pro Glu Arg 
        115                 120                 125             


His Asn Phe Thr Gln Glu Cys Asn Cys Ser Ile Tyr Gln Gly His Ile 
    130                 135                 140                 


Thr Gly His Arg Met Ala Trp Asp Met Met Leu Asn Trp Ser Thr Thr 
145                 150                 155                 160 


Leu Thr Met Ile Leu Ala Tyr Ala Ala Arg Val Pro Glu Leu Val Leu 
                165                 170                 175     


Glu Val Val Phe Gly Gly His Trp Gly Val Val Phe Gly Leu Ala Tyr 
            180                 185                 190         


Phe Ser Met Gln Gly Ala Trp Ala Lys Val Ile Ala Ile Leu Leu Leu 
        195                 200                 205             


Val Ala Gly Val Asp Ala 
    210                 


<210>  8
<211>  367
<212>  PRT
<213>  Hepatitis C virus Type 2b

<400>  8

Glu Thr His Thr Thr Gly Ser Ala Ala Gly His Ala Ala Arg Gly Phe 
1               5                   10                  15      


Ala Asn Leu Leu Ser Pro Gly Ser Lys Gln Lys Ile Ser Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Val Asn Asn Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Arg Gly Leu Asp 
65                  70                  75                  80  


Asp Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr 
                85                  90                  95      


Asn Glu Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro 
            100                 105                 110         


Cys Gly Ile Ile Ser Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe 
        115                 120                 125             


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Glu Gln Gly Leu Pro 
    130                 135                 140                 


Thr Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser 
145                 150                 155                 160 


Thr Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly 
                165                 170                 175     


Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg 
            180                 185                 190         


Asp Phe Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg 
        195                 200                 205             


Lys His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu 
    210                 215                 220                 


Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
225                 230                 235                 240 


Cys Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly 
                245                 250                 255     


Val Glu His Arg Leu Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg 
            260                 265                 270         


Cys Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His 
        275                 280                 285             


Ser Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro 
    290                 295                 300                 


Ala Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val 
305                 310                 315                 320 


Gln Tyr Leu Tyr Gly Leu Thr Pro Ala Ile Thr Lys Tyr Ile Val Lys 
                325                 330                 335     


Trp Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
            340                 345                 350         


Cys Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
        355                 360                 365         


<210>  9
<211>  214
<212>  PRT
<213>  Hepatitis C virus Type 3a

<400>  9

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Phe Ser Cys Leu 
1               5                   10                  15      


Ile His Pro Ala Ala Ser Leu Glu Trp Arg Asn Thr Ser Gly Leu Tyr 
            20                  25                  30          


Ile Leu Thr Asn Asp Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp 
        35                  40                  45              


Asp Val Ile Leu His Thr Pro Gly Cys Ile Pro Cys Val Gln Asp Gly 
    50                  55                  60                  


Asn Thr Ser Thr Cys Trp Thr Ser Val Thr Pro Thr Val Ala Val Arg 
65                  70                  75                  80  


Tyr Val Gly Ala Thr Thr Ala Ser Ile Arg Ser His Val Asp Leu Leu 
                85                  90                  95      


Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr Val Gly Asp Ala Cys 
            100                 105                 110         


Gly Ala Val Phe Leu Val Gly Gln Ala Phe Thr Phe Arg Pro Arg Arg 
        115                 120                 125             


His Gln Thr Val Gln Thr Cys Asn Cys Ser Leu Tyr Pro Gly His Leu 
    130                 135                 140                 


Thr Gly His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Ala 
145                 150                 155                 160 


Val Gly Met Val Val Ala His Val Leu Arg Leu Pro Gln Thr Leu Phe 
                165                 170                 175     


Asp Ile Ile Ala Gly Ala His Trp Gly Ile Leu Ala Gly Leu Ala Tyr 
            180                 185                 190         


Tyr Ser Met Gln Gly Asn Trp Ala Lys Val Val Ile Ile Met Val Met 
        195                 200                 205             


Phe Ser Gly Val Asp Ala 
    210                 


<210>  10
<211>  369
<212>  PRT
<213>  Hepatitis C virus Type 3a

<400>  10

Ser Thr Tyr Thr Thr Gly Gly Gln Ala Ala Arg Gly Ala Arg Gly Ile 
1               5                   10                  15      


Ala Gly Leu Phe Asp Leu Gly Ala Arg Gln Asn Leu Gln Leu Val Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu 
        35                  40                  45              


Ser Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe 
    50                  55                  60                  


Asn Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr 
65                  70                  75                  80  


Ser Phe Arg Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly 
                85                  90                  95      


Ser Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys 
            100                 105                 110         


Glu Ser Val Pro Ala Ser Lys Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr 
    130                 135                 140                 


Tyr Thr Trp Gly Ala Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Leu 
145                 150                 155                 160 


Arg Pro Pro Lys Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly 
            180                 185                 190         


Gly Gly Asn Ser Lys Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys 
        195                 200                 205             


Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro 
    210                 215                 220                 


Trp Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His 
225                 230                 235                 240 


Tyr Pro Cys Thr Val Asn Phe Thr Leu Phe Gln Val Arg Met Phe Val 
                245                 250                 255     


Gly Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly 
            260                 265                 270         


Glu Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu 
        275                 280                 285             


Leu His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro 
    290                 295                 300                 


Met Pro Ala Trp Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val 
305                 310                 315                 320 


Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala 
                325                 330                 335     


Leu Lys Trp Glu Phe Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala 
            340                 345                 350         


Arg Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu 
        355                 360                 365             


Ala 
    


<210>  11
<211>  214
<212>  PRT
<213>  Hepatitis C virus Type 4

<400>  11

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Val Pro Ala Ser Ala Ile Asn Tyr Arg Asn Val Ser Gly Ile Tyr 
            20                  25                  30          


His Val Thr Asn Asp Cys Pro Asn Ser Ser Ile Val Tyr Glu Thr Glu 
        35                  40                  45              


His His Ile Leu His Ile Pro Gly Cys Val Pro Cys Val Arg Val Gly 
    50                  55                  60                  


Asn Gln Ser Ser Cys Trp Val Ala Leu Thr Pro Thr Val Ala Thr Pro 
65                  70                  75                  80  


Tyr Ile Gly Ala Pro Leu Glu Ser Leu Arg Ser His Val Asp Leu Met 
                85                  90                  95      


Val Gly Ala Ala Thr Ala Cys Ser Ala Leu Tyr Ile Gly Asp Leu Cys 
            100                 105                 110         


Gly Gly Val Phe Leu Val Gly Gln Met Phe Ser Phe Arg Pro Arg Arg 
        115                 120                 125             


His Trp Thr Thr Gln Asp Cys Asn Cys Ser Ile Tyr Thr Gly His Ile 
    130                 135                 140                 


Thr Gly His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr 
145                 150                 155                 160 


Ala Thr Leu Val Leu Ala Gln Leu Met Arg Ile Pro Gly Ala Leu Val 
                165                 170                 175     


Asp Leu Leu Ala Gly Gly His Trp Gly Val Leu Val Gly Val Ala Tyr 
            180                 185                 190         


Phe Cys Met Gln Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe Leu 
        195                 200                 205             


Phe Ala Gly Val Asp Ala 
    210                 


<210>  12
<211>  363
<212>  PRT
<213>  Hepatitis C virus Type 4

<400>  12

Gln Thr Arg Leu Thr Gly Gly Thr Pro Ala His Gly Ala Gln Ser Ile 
1               5                   10                  15      


Ala Lys Leu Phe Ser Ala Gly Pro Arg Gln Asn Val Gln Leu Ile Asn 
            20                  25                  30          


Ser Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Phe Leu Thr Gly Leu Phe Tyr Val Ser Arg Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Lys Ser Leu Asp 
65                  70                  75                  80  


Ser Phe Asn Gln Gly Trp Gly Pro Leu Gly Ala Ala Asn Ile Ser Gly 
                85                  90                  95      


Pro Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys 
            100                 105                 110         


Gly Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr 
    130                 135                 140                 


Tyr Thr Trp Gly Asp Asn Glu Ser Asp Val Phe Leu Leu Asn Ala Thr 
145                 150                 155                 160 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Val Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Glu Val Lys Thr Asn 
            180                 185                 190         


Asn Gly Thr Trp Ser Cys Pro Thr Asp Cys Phe Arg Lys His Pro Ala 
        195                 200                 205             


Thr Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys 
    210                 215                 220                 


Leu Val His Tyr Pro Tyr Arg Leu Trp His Phe Pro Cys Thr Leu Asn 
225                 230                 235                 240 


Phe Thr Ile Phe Lys Val Arg Thr Tyr Ile Gly Gly Ile Glu His Arg 
                245                 250                 255     


Met Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Val Cys Gly Leu Glu 
            260                 265                 270         


His Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Thr 
        275                 280                 285             


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Ser Ala Cys Leu 
            340                 345                 350         


Trp Met Met Phe Met Val Ser Gln Val Glu Ala 
        355                 360             


<210>  13
<211>  214
<212>  PRT
<213>  Hepatitis C virus Type 5

<400>  13

Met Gly Cys Ser Phe Ser Ile Phe Ile Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Val Pro Ala Ser Ala Val Pro Tyr Arg Asn Ala Ser Gly Ile Tyr 
            20                  25                  30          


His Val Thr Asn Asp Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp 
        35                  40                  45              


Asn Leu Ile Leu His Ala Pro Gly Cys Val Pro Cys Val Arg Glu Gly 
    50                  55                  60                  


Asn Val Ser Arg Cys Trp Val Gln Ile Thr Pro Thr Leu Ser Ala Pro 
65                  70                  75                  80  


Asn Leu Gly Ala Val Thr Ala Pro Leu Arg Arg Ala Val Asp Tyr Leu 
                85                  90                  95      


Ala Gly Gly Ala Ala Leu Cys Ser Ala Leu Tyr Val Gly Asp Ala Cys 
            100                 105                 110         


Gly Ala Val Phe Leu Val Gly Gln Met Phe Thr Tyr Arg Pro Arg Gln 
        115                 120                 125             


His Thr Thr Val Gln Asp Cys Asn Cys Ser Ile Tyr Ser Gly His Val 
    130                 135                 140                 


Ser Gly His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr 
145                 150                 155                 160 


Ser Ala Leu Leu Val Ala Gln Met Leu Arg Ile Pro Gln Val Val Met 
                165                 170                 175     


Asp Ile Ile Ala Gly Gly His Trp Gly Val Leu Phe Ala Ala Ala Tyr 
            180                 185                 190         


Phe Ala Ser Ala Ala Asn Trp Ala Lys Val Val Leu Val Leu Phe Leu 
        195                 200                 205             


Phe Ala Gly Val Asp Gly 
    210                 


<210>  14
<211>  364
<212>  PRT
<213>  Hepatitis C virus Type 5

<400>  14

Asn Thr Gln Thr Val Gly Gly Ser Ala Ala Tyr Ser Thr Ser Gly Leu 
1               5                   10                  15      


Ala Ser Leu Phe Ser Pro Gly Pro Lys Gln Asn Leu Gln Leu Ile Gln 
            20                  25                  30          


Asn Gly Ser Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Lys Thr Gly Phe Ile Ala Gly Leu Met Tyr Val Tyr Lys Phe 
    50                  55                  60                  


Asn Ser Thr Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Thr 
65                  70                  75                  80  


Ala Phe Asp Gln Gly Trp Gly Thr Ile Ser Tyr Ala Asn Ile Ser Gly 
                85                  90                  95      


Pro Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
            100                 105                 110         


Gly Val Val Pro Ala Arg Glu Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Lys Gly Tyr Pro Thr 
    130                 135                 140                 


Tyr Asn Trp Gly Glu Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr 
145                 150                 155                 160 


Arg Pro Pro Thr Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ala Ser 
                165                 170                 175     


Gly Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Ile Leu Gly Pro Thr 
            180                 185                 190         


Gly Asn Asn Ser Leu Lys Cys Pro Thr Asp Cys Phe Arg Lys His Pro 
        195                 200                 205             


Asp Ala Thr Tyr Thr Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg 
    210                 215                 220                 


Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val 
225                 230                 235                 240 


Asn Tyr Thr Ile Phe Lys Val Arg Met Phe Ile Gly Gly Leu Glu His 
                245                 250                 255     


Arg Phe Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu 
            260                 265                 270         


Asp Asp Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu His Thr Thr Thr 
        275                 280                 285             


Gln Trp Ala Ile Leu Pro Cys Ser Phe Thr Pro Thr Pro Ala Leu Ser 
    290                 295                 300                 


Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Thr Gln Tyr Leu 
305                 310                 315                 320 


Tyr Gly Leu Ser Ser Ser Ile Val Ser Trp Ala Val Lys Trp Glu Tyr 
                325                 330                 335     


Ile Val Leu Ala Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Thr Cys 
            340                 345                 350         


Leu Trp Ile Met Leu Leu Val Cys Gln Ala Glu Ala 
        355                 360                 


<210>  15
<211>  214
<212>  PRT
<213>  Hepatitis C virus Type 6

<400>  15

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Thr Pro Ala Ser Ala Leu Thr Tyr Gly Asn Ser Ser Gly Leu Tyr 
            20                  25                  30          


His Leu Thr Asn Asp Cys Pro Asn Ser Ser Ile Val Leu Glu Ala Asp 
        35                  40                  45              


Ala Met Ile Leu His Leu Pro Gly Cys Leu Pro Cys Val Arg Val Asp 
    50                  55                  60                  


Asn Arg Ser Thr Cys Trp His Ala Val Ser Pro Thr Leu Ala Ile Pro 
65                  70                  75                  80  


Asn Ala Ser Thr Pro Ala Thr Gly Phe Arg Arg His Val Asp Leu Leu 
                85                  90                  95      


Ala Gly Ala Ala Val Val Cys Ser Ser Leu Tyr Ile Gly Asp Leu Cys 
            100                 105                 110         


Gly Ser Leu Phe Leu Ala Gly Gln Leu Phe Thr Phe Gln Pro Arg Arg 
        115                 120                 125             


His Trp Thr Val Gln Asp Cys Asn Cys Ser Ile Tyr Thr Gly His Val 
    130                 135                 140                 


Thr Gly His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr 
145                 150                 155                 160 


Thr Thr Leu Val Leu Ser Ser Ile Leu Arg Val Pro Glu Ile Cys Ala 
                165                 170                 175     


Ser Val Ile Leu Gly Gly His Trp Gly Ile Leu Leu Ala Val Ala Tyr 
            180                 185                 190         


Phe Gly Met Ala Gly Asn Trp Leu Lys Val Leu Ala Val Leu Phe Leu 
        195                 200                 205             


Phe Ala Gly Val Glu Ala 
    210                 


<210>  16
<211>  368
<212>  PRT
<213>  Hepatitis C virus Type 6

<400>  16

Thr Thr Thr Thr Ala His Glu Ala Ala Arg Ala Thr Ala Gly Phe Val 
1               5                   10                  15      


Gly Leu Phe Thr Ser Gly Ala Arg Gln Lys Leu Gln Leu Ile Asn Thr 
            20                  25                  30          


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
        35                  40                  45              


Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Phe Asn Lys Phe Asn 
    50                  55                  60                  


Ser Ser Gly Cys Pro Glu Arg Met Ala Ala Cys Lys Pro Leu Ala Asp 
65                  70                  75                  80  


Phe Arg Gln Gly Trp Gly Gln Ile Thr Tyr Lys Val Asn Ile Ser Gly 
                85                  90                  95      


Pro Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Ser Cys 
            100                 105                 110         


Asp Val Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Asn Pro Thr 
    130                 135                 140                 


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Met Leu Glu Ser Leu 
145                 150                 155                 160 


Arg Pro Pro Thr Gly Gly Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Gln Ile Val Pro Gly 
            180                 185                 190         


Asp Tyr Asn Ser Ser Ala Asn Glu Leu Leu Cys Pro Thr Asp Cys Phe 
        195                 200                 205             


Arg Lys His Pro Glu Ala Thr Tyr Gln Arg Cys Gly Ser Gly Pro Trp 
    210                 215                 220                 


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
225                 230                 235                 240 


Pro Cys Thr Val Asn Phe Thr Val His Lys Val Arg Met Phe Val Gly 
                245                 250                 255     


Gly Ile Glu His Arg Phe Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu 
            260                 265                 270         


Arg Cys Glu Leu His Asp Arg Asp Arg Ile Glu Met Ser Pro Leu Leu 
        275                 280                 285             


Phe Ser Thr Thr Gln Leu Ala Ile Leu Pro Cys Ser Phe Ser Thr Met 
    290                 295                 300                 


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
305                 310                 315                 320 


Val Gln Tyr Leu Tyr Gly Val Ser Ser Ser Val Thr Ser Trp Val Val 
                325                 330                 335     


Lys Trp Glu Tyr Ile Val Leu Met Phe Leu Val Leu Ala Asp Ala Arg 
            340                 345                 350         


Ile Cys Thr Cys Leu Trp Leu Met Leu Leu Ile Thr Asn Val Glu Ala 
        355                 360                 365             


