                         SEQUENCE LISTING

<110>  Yale University
       Weidhaas, Joanne B.
 
<120>  The KRAS Variant and Tumor Biology

<130>  34592-515001WO

<150>  61/454765
<151>  2011-03-21

<150>  61/454767
<151>  2011-03-21

<150>  61/454769
<151>  2011-03-21

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  1
gacaguggaa guuuuuuuuu ccucg                                             25


<210>  2
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  2
auuaguguca ucuugccuc                                                    19


<210>  3
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  3
aaugcccuac aucuuauuuu ccuca                                             25


<210>  4
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  4
gguucaagcg auucucgugc cucg                                              24


<210>  5
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  5
ggcugguccg aacuccugac cuca                                              24


<210>  6
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6
gauucaccca ccuuggccuc a                                                 21


<210>  7
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  7
ggguguuaag acuugacaca guaccucg                                          28


<210>  8
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  8
agugcuuaug aggggauauu uaggccuc                                          28


<210>  9
<211>  5436
<212>  DNA
<213>  Homo sapiens

<400>  9
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc       60

tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg      120

aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa      180

aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac      240

gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta      300

caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg      360

tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg      420

tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat      480

taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt      540

gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc      600

ttttattgaa acatcagcaa agacaagaca gagagtggag gatgcttttt atacattggt      660

gagggagatc cgacaataca gattgaaaaa aatcagcaaa gaagaaaaga ctcctggctg      720

tgtgaaaatt aaaaaatgca ttataatgta atctgggtgt tgatgatgcc ttctatacat      780

tagttcgaga aattcgaaaa cataaagaaa agatgagcaa agatggtaaa aagaagaaaa      840

agaagtcaaa gacaaagtgt gtaattatgt aaatacaatt tgtacttttt tcttaaggca      900

tactagtaca agtggtaatt tttgtacatt acactaaatt attagcattt gttttagcat      960

tacctaattt ttttcctgct ccatgcagac tgttagcttt taccttaaat gcttatttta     1020

aaatgacagt ggaagttttt ttttcctcta agtgccagta ttcccagagt tttggttttt     1080

gaactagcaa tgcctgtgaa aaagaaactg aatacctaag atttctgtct tggggttttt     1140

ggtgcatgca gttgattact tcttattttt cttaccaatt gtgaatgttg gtgtgaaaca     1200

aattaatgaa gcttttgaat catccctatt ctgtgtttta tctagtcaca taaatggatt     1260

aattactaat ttcagttgag accttctaat tggtttttac tgaaacattg agggaacaca     1320

aatttatggg cttcctgatg atgattcttc taggcatcat gtcctatagt ttgtcatccc     1380

tgatgaatgt aaagttacac tgttcacaaa ggttttgtct cctttccact gctattagtc     1440

atggtcactc tccccaaaat attatatttt ttctataaaa agaaaaaaat ggaaaaaaat     1500

tacaaggcaa tggaaactat tataaggcca tttccttttc acattagata aattactata     1560

aagactccta atagcttttc ctgttaaggc agacccagta tgaaatgggg attattatag     1620

caaccatttt ggggctatat ttacatgcta ctaaattttt ataataattg aaaagatttt     1680

aacaagtata aaaaattctc ataggaatta aatgtagtct ccctgtgtca gactgctctt     1740

tcatagtata actttaaatc ttttcttcaa cttgagtctt tgaagatagt tttaattctg     1800

cttgtgacat taaaagatta tttgggccag ttatagctta ttaggtgttg aagagaccaa     1860

ggttgcaagg ccaggccctg tgtgaacctt tgagctttca tagagagttt cacagcatgg     1920

actgtgtccc cacggtcatc cagtgttgtc atgcattggt tagtcaaaat ggggagggac     1980

tagggcagtt tggatagctc aacaagatac aatctcactc tgtggtggtc ctgctgacaa     2040

atcaagagca ttgcttttgt ttcttaagaa aacaaactct tttttaaaaa ttacttttaa     2100

atattaactc aaaagttgag attttggggt ggtggtgtgc caagacatta attttttttt     2160

taaacaatga agtgaaaaag ttttacaatc tctaggtttg gctagttctc ttaacactgg     2220

ttaaattaac attgcataaa cacttttcaa gtctgatcca tatttaataa tgctttaaaa     2280

taaaaataaa aacaatcctt ttgataaatt taaaatgtta cttattttaa aataaatgaa     2340

gtgagatggc atggtgaggt gaaagtatca ctggactagg aagaaggtga cttaggttct     2400

agataggtgt cttttaggac tctgattttg aggacatcac ttactatcca tttcttcatg     2460

ttaaaagaag tcatctcaaa ctcttagttt ttttttttta caactatgta atttatattc     2520

catttacata aggatacact tatttgtcaa gctcagcaca atctgtaaat ttttaaccta     2580

tgttacacca tcttcagtgc cagtcttggg caaaattgtg caagaggtga agtttatatt     2640

tgaatatcca ttctcgtttt aggactcttc ttccatatta gtgtcatctt gcctccctac     2700

cttccacatg ccccatgact tgatgcagtt ttaatacttg taattcccct aaccataaga     2760

tttactgctg ctgtggatat ctccatgaag ttttcccact gagtcacatc agaaatgccc     2820

tacatcttat ttcctcaggg ctcaagagaa tctgacagat accataaagg gatttgacct     2880

aatcactaat tttcaggtgg tggctgatgc tttgaacatc tctttgctgc ccaatccatt     2940

agcgacagta ggatttttca aacctggtat gaatagacag aaccctatcc agtggaagga     3000

gaatttaata aagatagtgc tgaaagaatt ccttaggtaa tctataacta ggactactcc     3060

tggtaacagt aatacattcc attgttttag taaccagaaa tcttcatgca atgaaaaata     3120

ctttaattca tgaagcttac tttttttttt tggtgtcaga gtctcgctct tgtcacccag     3180

gctggaatgc agtggcgcca tctcagctca ctgcaacctc catctcccag gttcaagcga     3240

ttctcgtgcc tcggcctcct gagtagctgg gattacaggc gtgtgccact acactcaact     3300

aatttttgta tttttaggag agacggggtt tcaccctgtt ggccaggctg gtctcgaact     3360

cctgacctca agtgattcac ccaccttggc ctcataaacc tgttttgcag aactcattta     3420

ttcagcaaat atttattgag tgcctaccag atgccagtca ccgcacaagg cactgggtat     3480

atggtatccc caaacaagag acataatccc ggtccttagg tagtgctagt gtggtctgta     3540

atatcttact aaggcctttg gtatacgacc cagagataac acgatgcgta ttttagtttt     3600

gcaaagaagg ggtttggtct ctgtgccagc tctataattg ttttgctacg attccactga     3660

aactcttcga tcaagctact ttatgtaaat cacttcattg ttttaaagga ataaacttga     3720

ttatattgtt tttttatttg gcataactgt gattctttta ggacaattac tgtacacatt     3780

aaggtgtatg tcagatattc atattgaccc aaatgtgtaa tattccagtt ttctctgcat     3840

aagtaattaa aatatactta aaaattaata gttttatctg ggtacaaata aacaggtgcc     3900

tgaactagtt cacagacaag gaaacttcta tgtaaaaatc actatgattt ctgaattgct     3960

atgtgaaact acagatcttt ggaacactgt ttaggtaggg tgttaagact tacacagtac     4020

ctcgtttcta cacagagaaa gaaatggcca tacttcagga actgcagtgc ttatgagggg     4080

atatttaggc ctcttgaatt tttgatgtag atgggcattt ttttaaggta gtggttaatt     4140

acctttatgt gaactttgaa tggtttaaca aaagatttgt ttttgtagag attttaaagg     4200

gggagaattc tagaaataaa tgttacctaa ttattacagc cttaaagaca aaaatccttg     4260

ttgaagtttt tttaaaaaaa gctaaattac atagacttag gcattaacat gtttgtggaa     4320

gaatatagca gacgtatatt gtatcatttg agtgaatgtt cccaagtagg cattctaggc     4380

tctatttaac tgagtcacac tgcataggaa tttagaacct aacttttata ggttatcaaa     4440

actgttgtca ccattgcaca attttgtcct aatatataca tagaaacttt gtggggcatg     4500

ttaagttaca gtttgcacaa gttcatctca tttgtattcc attgattttt tttttcttct     4560

aaacattttt tcttcaaaca gtatataact ttttttaggg gatttttttt tagacagcaa     4620

aaactatctg aagatttcca tttgtcaaaa agtaatgatt tcttgataat tgtgtagtaa     4680

tgttttttag aacccagcag ttaccttaaa gctgaattta tatttagtaa cttctgtgtt     4740

aatactggat agcatgaatt ctgcattgag aaactgaata gctgtcataa aatgaaactt     4800

tctttctaaa gaaagatact cacatgagtt cttgaagaat agtcataact agattaagat     4860

ctgtgtttta gtttaatagt ttgaagtgcc tgtttgggat aatgataggt aatttagatg     4920

aatttagggg aaaaaaaagt tatctgcaga tatgttgagg gcccatctct ccccccacac     4980

ccccacagag ctaactgggt tacagtgttt tatccgaaag tttccaattc cactgtcttg     5040

tgttttcatg ttgaaaatac ttttgcattt ttcctttgag tgccaatttc ttactagtac     5100

tatttcttaa tgtaacatgt ttacctggaa tgtattttaa ctatttttgt atagtgtaaa     5160

ctgaaacatg cacattttgt acattgtgct ttcttttgtg ggacatatgc agtgtgatcc     5220

agttgttttc catcatttgg ttgcgctgac ctaggaatgt tggtcatatc aaacattaaa     5280

aatgaccact cttttaattg aaattaactt ttaaatgttt ataggagtat gtgctgtgaa     5340

gtgatctaaa atttgtaata tttttgtcat gaactgtact actcctaatt attgtaatgt     5400

aataaaaata gttacagtga caaaaaaaaa aaaaaa                               5436


<210>  10
<211>  5312
<212>  DNA
<213>  Homo sapiens

<400>  10
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc       60

tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg      120

aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa      180

aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac      240

gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta      300

caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg      360

tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg      420

tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat      480

taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt      540

gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc      600

ttttattgaa acatcagcaa agacaagaca gggtgttgat gatgccttct atacattagt      660

tcgagaaatt cgaaaacata aagaaaagat gagcaaagat ggtaaaaaga agaaaaagaa      720

gtcaaagaca aagtgtgtaa ttatgtaaat acaatttgta cttttttctt aaggcatact      780

agtacaagtg gtaatttttg tacattacac taaattatta gcatttgttt tagcattacc      840

taattttttt cctgctccat gcagactgtt agcttttacc ttaaatgctt attttaaaat      900

gacagtggaa gttttttttt cctctaagtg ccagtattcc cagagttttg gtttttgaac      960

tagcaatgcc tgtgaaaaag aaactgaata cctaagattt ctgtcttggg gtttttggtg     1020

catgcagttg attacttctt atttttctta ccaattgtga atgttggtgt gaaacaaatt     1080

aatgaagctt ttgaatcatc cctattctgt gttttatcta gtcacataaa tggattaatt     1140

actaatttca gttgagacct tctaattggt ttttactgaa acattgaggg aacacaaatt     1200

tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt catccctgat     1260

gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta ttagtcatgg     1320

tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa aaaaattaca     1380

aggcaatgga aactattata aggccatttc cttttcacat tagataaatt actataaaga     1440

ctcctaatag cttttcctgt taaggcagac ccagtatgaa atggggatta ttatagcaac     1500

cattttgggg ctatatttac atgctactaa atttttataa taattgaaaa gattttaaca     1560

agtataaaaa attctcatag gaattaaatg tagtctccct gtgtcagact gctctttcat     1620

agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta attctgcttg     1680

tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga gaccaaggtt     1740

gcaaggccag gccctgtgtg aacctttgag ctttcataga gagtttcaca gcatggactg     1800

tgtccccacg gtcatccagt gttgtcatgc attggttagt caaaatgggg agggactagg     1860

gcagtttgga tagctcaaca agatacaatc tcactctgtg gtggtcctgc tgacaaatca     1920

agagcattgc ttttgtttct taagaaaaca aactcttttt taaaaattac ttttaaatat     1980

taactcaaaa gttgagattt tggggtggtg gtgtgccaag acattaattt tttttttaaa     2040

caatgaagtg aaaaagtttt acaatctcta ggtttggcta gttctcttaa cactggttaa     2100

attaacattg cataaacact tttcaagtct gatccatatt taataatgct ttaaaataaa     2160

aataaaaaca atccttttga taaatttaaa atgttactta ttttaaaata aatgaagtga     2220

gatggcatgg tgaggtgaaa gtatcactgg actaggaaga aggtgactta ggttctagat     2280

aggtgtcttt taggactctg attttgagga catcacttac tatccatttc ttcatgttaa     2340

aagaagtcat ctcaaactct tagttttttt tttttacaac tatgtaattt atattccatt     2400

tacataagga tacacttatt tgtcaagctc agcacaatct gtaaattttt aacctatgtt     2460

acaccatctt cagtgccagt cttgggcaaa attgtgcaag aggtgaagtt tatatttgaa     2520

tatccattct cgttttagga ctcttcttcc atattagtgt catcttgcct ccctaccttc     2580

cacatgcccc atgacttgat gcagttttaa tacttgtaat tcccctaacc ataagattta     2640

ctgctgctgt ggatatctcc atgaagtttt cccactgagt cacatcagaa atgccctaca     2700

tcttatttcc tcagggctca agagaatctg acagatacca taaagggatt tgacctaatc     2760

actaattttc aggtggtggc tgatgctttg aacatctctt tgctgcccaa tccattagcg     2820

acagtaggat ttttcaaacc tggtatgaat agacagaacc ctatccagtg gaaggagaat     2880

ttaataaaga tagtgctgaa agaattcctt aggtaatcta taactaggac tactcctggt     2940

aacagtaata cattccattg ttttagtaac cagaaatctt catgcaatga aaaatacttt     3000

aattcatgaa gcttactttt tttttttggt gtcagagtct cgctcttgtc acccaggctg     3060

gaatgcagtg gcgccatctc agctcactgc aacctccatc tcccaggttc aagcgattct     3120

cgtgcctcgg cctcctgagt agctgggatt acaggcgtgt gccactacac tcaactaatt     3180

tttgtatttt taggagagac ggggtttcac cctgttggcc aggctggtct cgaactcctg     3240

acctcaagtg attcacccac cttggcctca taaacctgtt ttgcagaact catttattca     3300

gcaaatattt attgagtgcc taccagatgc cagtcaccgc acaaggcact gggtatatgg     3360

tatccccaaa caagagacat aatcccggtc cttaggtagt gctagtgtgg tctgtaatat     3420

cttactaagg cctttggtat acgacccaga gataacacga tgcgtatttt agttttgcaa     3480

agaaggggtt tggtctctgt gccagctcta taattgtttt gctacgattc cactgaaact     3540

cttcgatcaa gctactttat gtaaatcact tcattgtttt aaaggaataa acttgattat     3600

attgtttttt tatttggcat aactgtgatt cttttaggac aattactgta cacattaagg     3660

tgtatgtcag atattcatat tgacccaaat gtgtaatatt ccagttttct ctgcataagt     3720

aattaaaata tacttaaaaa ttaatagttt tatctgggta caaataaaca ggtgcctgaa     3780

ctagttcaca gacaaggaaa cttctatgta aaaatcacta tgatttctga attgctatgt     3840

gaaactacag atctttggaa cactgtttag gtagggtgtt aagacttaca cagtacctcg     3900

tttctacaca gagaaagaaa tggccatact tcaggaactg cagtgcttat gaggggatat     3960

ttaggcctct tgaatttttg atgtagatgg gcattttttt aaggtagtgg ttaattacct     4020

ttatgtgaac tttgaatggt ttaacaaaag atttgttttt gtagagattt taaaggggga     4080

gaattctaga aataaatgtt acctaattat tacagcctta aagacaaaaa tccttgttga     4140

agttttttta aaaaaagcta aattacatag acttaggcat taacatgttt gtggaagaat     4200

atagcagacg tatattgtat catttgagtg aatgttccca agtaggcatt ctaggctcta     4260

tttaactgag tcacactgca taggaattta gaacctaact tttataggtt atcaaaactg     4320

ttgtcaccat tgcacaattt tgtcctaata tatacataga aactttgtgg ggcatgttaa     4380

gttacagttt gcacaagttc atctcatttg tattccattg attttttttt tcttctaaac     4440

attttttctt caaacagtat ataacttttt ttaggggatt tttttttaga cagcaaaaac     4500

tatctgaaga tttccatttg tcaaaaagta atgatttctt gataattgtg tagtaatgtt     4560

ttttagaacc cagcagttac cttaaagctg aatttatatt tagtaacttc tgtgttaata     4620

ctggatagca tgaattctgc attgagaaac tgaatagctg tcataaaatg aaactttctt     4680

tctaaagaaa gatactcaca tgagttcttg aagaatagtc ataactagat taagatctgt     4740

gttttagttt aatagtttga agtgcctgtt tgggataatg ataggtaatt tagatgaatt     4800

taggggaaaa aaaagttatc tgcagatatg ttgagggccc atctctcccc ccacaccccc     4860

acagagctaa ctgggttaca gtgttttatc cgaaagtttc caattccact gtcttgtgtt     4920

ttcatgttga aaatactttt gcatttttcc tttgagtgcc aatttcttac tagtactatt     4980

tcttaatgta acatgtttac ctggaatgta ttttaactat ttttgtatag tgtaaactga     5040

aacatgcaca ttttgtacat tgtgctttct tttgtgggac atatgcagtg tgatccagtt     5100

gttttccatc atttggttgc gctgacctag gaatgttggt catatcaaac attaaaaatg     5160

accactcttt taattgaaat taacttttaa atgtttatag gagtatgtgc tgtgaagtga     5220

tctaaaattt gtaatatttt tgtcatgaac tgtactactc ctaattattg taatgtaata     5280

aaaatagtta cagtgacaaa aaaaaaaaaa aa                                   5312


<210>  11
<211>  5436
<212>  DNA
<213>  Homo sapiens

<400>  11
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc       60

tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg      120

aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa      180

aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac      240

gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta      300

caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg      360

tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg      420

tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat      480

taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt      540

gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc      600

ttttattgaa acatcagcaa agacaagaca gagagtggag gatgcttttt atacattggt      660

gagggagatc cgacaataca gattgaaaaa aatcagcaaa gaagaaaaga ctcctggctg      720

tgtgaaaatt aaaaaatgca ttataatgta atctgggtgt tgatgatgcc ttctatacat      780

tagttcgaga aattcgaaaa cataaagaaa agatgagcaa agatggtaaa aagaagaaaa      840

agaagtcaaa gacaaagtgt gtaattatgt aaatacaatt tgtacttttt tcttaaggca      900

tactagtaca agtggtaatt tttgtacatt acactaaatt attagcattt gttttagcat      960

tacctaattt ttttcctgct ccatgcagac tgttagcttt taccttaaat gcttatttta     1020

aaatgacagt ggaagttttt ttttcctcta agtgccagta ttcccagagt tttggttttt     1080

gaactagcaa tgcctgtgaa aaagaaactg aatacctaag atttctgtct tggggttttt     1140

ggtgcatgca gttgattact tcttattttt cttaccaatt gtgaatgttg gtgtgaaaca     1200

aattaatgaa gcttttgaat catccctatt ctgtgtttta tctagtcaca taaatggatt     1260

aattactaat ttcagttgag accttctaat tggtttttac tgaaacattg agggaacaca     1320

aatttatggg cttcctgatg atgattcttc taggcatcat gtcctatagt ttgtcatccc     1380

tgatgaatgt aaagttacac tgttcacaaa ggttttgtct cctttccact gctattagtc     1440

atggtcactc tccccaaaat attatatttt ttctataaaa agaaaaaaat ggaaaaaaat     1500

tacaaggcaa tggaaactat tataaggcca tttccttttc acattagata aattactata     1560

aagactccta atagcttttc ctgttaaggc agacccagta tgaaatgggg attattatag     1620

caaccatttt ggggctatat ttacatgcta ctaaattttt ataataattg aaaagatttt     1680

aacaagtata aaaaattctc ataggaatta aatgtagtct ccctgtgtca gactgctctt     1740

tcatagtata actttaaatc ttttcttcaa cttgagtctt tgaagatagt tttaattctg     1800

cttgtgacat taaaagatta tttgggccag ttatagctta ttaggtgttg aagagaccaa     1860

ggttgcaagg ccaggccctg tgtgaacctt tgagctttca tagagagttt cacagcatgg     1920

actgtgtccc cacggtcatc cagtgttgtc atgcattggt tagtcaaaat ggggagggac     1980

tagggcagtt tggatagctc aacaagatac aatctcactc tgtggtggtc ctgctgacaa     2040

atcaagagca ttgcttttgt ttcttaagaa aacaaactct tttttaaaaa ttacttttaa     2100

atattaactc aaaagttgag attttggggt ggtggtgtgc caagacatta attttttttt     2160

taaacaatga agtgaaaaag ttttacaatc tctaggtttg gctagttctc ttaacactgg     2220

ttaaattaac attgcataaa cacttttcaa gtctgatcca tatttaataa tgctttaaaa     2280

taaaaataaa aacaatcctt ttgataaatt taaaatgtta cttattttaa aataaatgaa     2340

gtgagatggc atggtgaggt gaaagtatca ctggactagg aagaaggtga cttaggttct     2400

agataggtgt cttttaggac tctgattttg aggacatcac ttactatcca tttcttcatg     2460

ttaaaagaag tcatctcaaa ctcttagttt ttttttttta caactatgta atttatattc     2520

catttacata aggatacact tatttgtcaa gctcagcaca atctgtaaat ttttaaccta     2580

tgttacacca tcttcagtgc cagtcttggg caaaattgtg caagaggtga agtttatatt     2640

tgaatatcca ttctcgtttt aggactcttc ttccatatta gtgtcatctt gcctccctac     2700

cttccacatg ccccatgact tgatgcagtt ttaatacttg taattcccct aaccataaga     2760

tttactgctg ctgtggatat ctccatgaag ttttcccact gagtcacatc agaaatgccc     2820

tacatcttat ttcctcaggg ctcaagagaa tctgacagat accataaagg gatttgacct     2880

aatcactaat tttcaggtgg tggctgatgc tttgaacatc tctttgctgc ccaatccatt     2940

agcgacagta ggatttttca aacctggtat gaatagacag aaccctatcc agtggaagga     3000

gaatttaata aagatagtgc tgaaagaatt ccttaggtaa tctataacta ggactactcc     3060

tggtaacagt aatacattcc attgttttag taaccagaaa tcttcatgca atgaaaaata     3120

ctttaattca tgaagcttac tttttttttt tggtgtcaga gtctcgctct tgtcacccag     3180

gctggaatgc agtggcgcca tctcagctca ctgcaacctc catctcccag gttcaagcga     3240

ttctcgtgcc tcggcctcct gagtagctgg gattacaggc gtgtgccact acactcaact     3300

aatttttgta tttttaggag agacggggtt tcaccctgtt ggccaggctg gtctcgaact     3360

cctgacctca agtgatgcac ccaccttggc ctcataaacc tgttttgcag aactcattta     3420

ttcagcaaat atttattgag tgcctaccag atgccagtca ccgcacaagg cactgggtat     3480

atggtatccc caaacaagag acataatccc ggtccttagg tagtgctagt gtggtctgta     3540

atatcttact aaggcctttg gtatacgacc cagagataac acgatgcgta ttttagtttt     3600

gcaaagaagg ggtttggtct ctgtgccagc tctataattg ttttgctacg attccactga     3660

aactcttcga tcaagctact ttatgtaaat cacttcattg ttttaaagga ataaacttga     3720

ttatattgtt tttttatttg gcataactgt gattctttta ggacaattac tgtacacatt     3780

aaggtgtatg tcagatattc atattgaccc aaatgtgtaa tattccagtt ttctctgcat     3840

aagtaattaa aatatactta aaaattaata gttttatctg ggtacaaata aacaggtgcc     3900

tgaactagtt cacagacaag gaaacttcta tgtaaaaatc actatgattt ctgaattgct     3960

atgtgaaact acagatcttt ggaacactgt ttaggtaggg tgttaagact tacacagtac     4020

ctcgtttcta cacagagaaa gaaatggcca tacttcagga actgcagtgc ttatgagggg     4080

atatttaggc ctcttgaatt tttgatgtag atgggcattt ttttaaggta gtggttaatt     4140

acctttatgt gaactttgaa tggtttaaca aaagatttgt ttttgtagag attttaaagg     4200

gggagaattc tagaaataaa tgttacctaa ttattacagc cttaaagaca aaaatccttg     4260

ttgaagtttt tttaaaaaaa gctaaattac atagacttag gcattaacat gtttgtggaa     4320

gaatatagca gacgtatatt gtatcatttg agtgaatgtt cccaagtagg cattctaggc     4380

tctatttaac tgagtcacac tgcataggaa tttagaacct aacttttata ggttatcaaa     4440

actgttgtca ccattgcaca attttgtcct aatatataca tagaaacttt gtggggcatg     4500

ttaagttaca gtttgcacaa gttcatctca tttgtattcc attgattttt tttttcttct     4560

aaacattttt tcttcaaaca gtatataact ttttttaggg gatttttttt tagacagcaa     4620

aaactatctg aagatttcca tttgtcaaaa agtaatgatt tcttgataat tgtgtagtaa     4680

tgttttttag aacccagcag ttaccttaaa gctgaattta tatttagtaa cttctgtgtt     4740

aatactggat agcatgaatt ctgcattgag aaactgaata gctgtcataa aatgaaactt     4800

tctttctaaa gaaagatact cacatgagtt cttgaagaat agtcataact agattaagat     4860

ctgtgtttta gtttaatagt ttgaagtgcc tgtttgggat aatgataggt aatttagatg     4920

aatttagggg aaaaaaaagt tatctgcaga tatgttgagg gcccatctct ccccccacac     4980

ccccacagag ctaactgggt tacagtgttt tatccgaaag tttccaattc cactgtcttg     5040

tgttttcatg ttgaaaatac ttttgcattt ttcctttgag tgccaatttc ttactagtac     5100

tatttcttaa tgtaacatgt ttacctggaa tgtattttaa ctatttttgt atagtgtaaa     5160

ctgaaacatg cacattttgt acattgtgct ttcttttgtg ggacatatgc agtgtgatcc     5220

agttgttttc catcatttgg ttgcgctgac ctaggaatgt tggtcatatc aaacattaaa     5280

aatgaccact cttttaattg aaattaactt ttaaatgttt ataggagtat gtgctgtgaa     5340

gtgatctaaa atttgtaata tttttgtcat gaactgtact actcctaatt attgtaatgt     5400

aataaaaata gttacagtga caaaaaaaaa aaaaaa                               5436


<210>  12
<211>  5312
<212>  DNA
<213>  Homo sapiens

<400>  12
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc       60

tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg      120

aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa      180

aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac      240

gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta      300

caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg      360

tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg      420

tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat      480

taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt      540

gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc      600

ttttattgaa acatcagcaa agacaagaca gggtgttgat gatgccttct atacattagt      660

tcgagaaatt cgaaaacata aagaaaagat gagcaaagat ggtaaaaaga agaaaaagaa      720

gtcaaagaca aagtgtgtaa ttatgtaaat acaatttgta cttttttctt aaggcatact      780

agtacaagtg gtaatttttg tacattacac taaattatta gcatttgttt tagcattacc      840

taattttttt cctgctccat gcagactgtt agcttttacc ttaaatgctt attttaaaat      900

gacagtggaa gttttttttt cctctaagtg ccagtattcc cagagttttg gtttttgaac      960

tagcaatgcc tgtgaaaaag aaactgaata cctaagattt ctgtcttggg gtttttggtg     1020

catgcagttg attacttctt atttttctta ccaattgtga atgttggtgt gaaacaaatt     1080

aatgaagctt ttgaatcatc cctattctgt gttttatcta gtcacataaa tggattaatt     1140

actaatttca gttgagacct tctaattggt ttttactgaa acattgaggg aacacaaatt     1200

tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt catccctgat     1260

gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta ttagtcatgg     1320

tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa aaaaattaca     1380

aggcaatgga aactattata aggccatttc cttttcacat tagataaatt actataaaga     1440

ctcctaatag cttttcctgt taaggcagac ccagtatgaa atggggatta ttatagcaac     1500

cattttgggg ctatatttac atgctactaa atttttataa taattgaaaa gattttaaca     1560

agtataaaaa attctcatag gaattaaatg tagtctccct gtgtcagact gctctttcat     1620

agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta attctgcttg     1680

tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga gaccaaggtt     1740

gcaaggccag gccctgtgtg aacctttgag ctttcataga gagtttcaca gcatggactg     1800

tgtccccacg gtcatccagt gttgtcatgc attggttagt caaaatgggg agggactagg     1860

gcagtttgga tagctcaaca agatacaatc tcactctgtg gtggtcctgc tgacaaatca     1920

agagcattgc ttttgtttct taagaaaaca aactcttttt taaaaattac ttttaaatat     1980

taactcaaaa gttgagattt tggggtggtg gtgtgccaag acattaattt tttttttaaa     2040

caatgaagtg aaaaagtttt acaatctcta ggtttggcta gttctcttaa cactggttaa     2100

attaacattg cataaacact tttcaagtct gatccatatt taataatgct ttaaaataaa     2160

aataaaaaca atccttttga taaatttaaa atgttactta ttttaaaata aatgaagtga     2220

gatggcatgg tgaggtgaaa gtatcactgg actaggaaga aggtgactta ggttctagat     2280

aggtgtcttt taggactctg attttgagga catcacttac tatccatttc ttcatgttaa     2340

aagaagtcat ctcaaactct tagttttttt tttttacaac tatgtaattt atattccatt     2400

tacataagga tacacttatt tgtcaagctc agcacaatct gtaaattttt aacctatgtt     2460

acaccatctt cagtgccagt cttgggcaaa attgtgcaag aggtgaagtt tatatttgaa     2520

tatccattct cgttttagga ctcttcttcc atattagtgt catcttgcct ccctaccttc     2580

cacatgcccc atgacttgat gcagttttaa tacttgtaat tcccctaacc ataagattta     2640

ctgctgctgt ggatatctcc atgaagtttt cccactgagt cacatcagaa atgccctaca     2700

tcttatttcc tcagggctca agagaatctg acagatacca taaagggatt tgacctaatc     2760

actaattttc aggtggtggc tgatgctttg aacatctctt tgctgcccaa tccattagcg     2820

acagtaggat ttttcaaacc tggtatgaat agacagaacc ctatccagtg gaaggagaat     2880

ttaataaaga tagtgctgaa agaattcctt aggtaatcta taactaggac tactcctggt     2940

aacagtaata cattccattg ttttagtaac cagaaatctt catgcaatga aaaatacttt     3000

aattcatgaa gcttactttt tttttttggt gtcagagtct cgctcttgtc acccaggctg     3060

gaatgcagtg gcgccatctc agctcactgc aacctccatc tcccaggttc aagcgattct     3120

cgtgcctcgg cctcctgagt agctgggatt acaggcgtgt gccactacac tcaactaatt     3180

tttgtatttt taggagagac ggggtttcac cctgttggcc aggctggtct cgaactcctg     3240

acctcaagtg atgcacccac cttggcctca taaacctgtt ttgcagaact catttattca     3300

gcaaatattt attgagtgcc taccagatgc cagtcaccgc acaaggcact gggtatatgg     3360

tatccccaaa caagagacat aatcccggtc cttaggtagt gctagtgtgg tctgtaatat     3420

cttactaagg cctttggtat acgacccaga gataacacga tgcgtatttt agttttgcaa     3480

agaaggggtt tggtctctgt gccagctcta taattgtttt gctacgattc cactgaaact     3540

cttcgatcaa gctactttat gtaaatcact tcattgtttt aaaggaataa acttgattat     3600

attgtttttt tatttggcat aactgtgatt cttttaggac aattactgta cacattaagg     3660

tgtatgtcag atattcatat tgacccaaat gtgtaatatt ccagttttct ctgcataagt     3720

aattaaaata tacttaaaaa ttaatagttt tatctgggta caaataaaca ggtgcctgaa     3780

ctagttcaca gacaaggaaa cttctatgta aaaatcacta tgatttctga attgctatgt     3840

gaaactacag atctttggaa cactgtttag gtagggtgtt aagacttaca cagtacctcg     3900

tttctacaca gagaaagaaa tggccatact tcaggaactg cagtgcttat gaggggatat     3960

ttaggcctct tgaatttttg atgtagatgg gcattttttt aaggtagtgg ttaattacct     4020

ttatgtgaac tttgaatggt ttaacaaaag atttgttttt gtagagattt taaaggggga     4080

gaattctaga aataaatgtt acctaattat tacagcctta aagacaaaaa tccttgttga     4140

agttttttta aaaaaagcta aattacatag acttaggcat taacatgttt gtggaagaat     4200

atagcagacg tatattgtat catttgagtg aatgttccca agtaggcatt ctaggctcta     4260

tttaactgag tcacactgca taggaattta gaacctaact tttataggtt atcaaaactg     4320

ttgtcaccat tgcacaattt tgtcctaata tatacataga aactttgtgg ggcatgttaa     4380

gttacagttt gcacaagttc atctcatttg tattccattg attttttttt tcttctaaac     4440

attttttctt caaacagtat ataacttttt ttaggggatt tttttttaga cagcaaaaac     4500

tatctgaaga tttccatttg tcaaaaagta atgatttctt gataattgtg tagtaatgtt     4560

ttttagaacc cagcagttac cttaaagctg aatttatatt tagtaacttc tgtgttaata     4620

ctggatagca tgaattctgc attgagaaac tgaatagctg tcataaaatg aaactttctt     4680

tctaaagaaa gatactcaca tgagttcttg aagaatagtc ataactagat taagatctgt     4740

gttttagttt aatagtttga agtgcctgtt tgggataatg ataggtaatt tagatgaatt     4800

taggggaaaa aaaagttatc tgcagatatg ttgagggccc atctctcccc ccacaccccc     4860

acagagctaa ctgggttaca gtgttttatc cgaaagtttc caattccact gtcttgtgtt     4920

ttcatgttga aaatactttt gcatttttcc tttgagtgcc aatttcttac tagtactatt     4980

tcttaatgta acatgtttac ctggaatgta ttttaactat ttttgtatag tgtaaactga     5040

aacatgcaca ttttgtacat tgtgctttct tttgtgggac atatgcagtg tgatccagtt     5100

gttttccatc atttggttgc gctgacctag gaatgttggt catatcaaac attaaaaatg     5160

accactcttt taattgaaat taacttttaa atgtttatag gagtatgtgc tgtgaagtga     5220

tctaaaattt gtaatatttt tgtcatgaac tgtactactc ctaattattg taatgtaata     5280

aaaatagtta cagtgacaaa aaaaaaaaaa aa                                   5312


<210>  13
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  13
gaugcaccca ccuuggccuc a                                                 21


<210>  14
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  14
uugauauguu ggaugaugga gu                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  15
uugguguguu ggaugaugga gu                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  16
uugguauguu ggaugaugga gu                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  17
ugauacguug gaugauggag a                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  18
uauauguugg aggauggagu                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  19
uugauauguu agaugaugga gu                                                22


<210>  20
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  20
gacauguuug augauggagu                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  21
ugucguguuu guugauggag u                                                 21


<210>  22
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  22
gtctcgaact cctgacctca agtgatgcac ccaccttggc ctcataaacc tg               52


<210>  23
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  23
ugcaucacuu gaggucagga g                                                 21


<210>  24
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  24
ccugaccuca agugaugcac c                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  25
tgcatcacuu gaggucagga g                                                 21


<210>  26
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  26
ucaucacuug aggucaggag u                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  27
uccugaccuc aagugaugca c                                                 21


<210>  28
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  28
gccaggctgg tctcgaa                                                      17


<210>  29
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  29
ctgaataaat gagttctgca aaacaggtt                                         29


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  30
ctcaagtgat tcacccac                                                     18


<210>  31
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  31
caagtgattc acccac                                                       16


