
SEQUENCE LISTING

<110> OPTION PHARMACEUTICALS, LLC
      LAUERMAN, Tod

<120> TARGETED CYTOKINE FOR TREATMENT OF MUSCULOSKELETAL DISEASES

<130> 655162000440

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> US 61/466,877       
<151> 2011-03-23  

<160> 5

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature         
<222> (1)...(112)
<223> coding sequence of human TGF-beta 1

<400> 1
Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys
 1               5                  10                  15      
Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp
            20                  25                  30          
Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys
        35                  40                  45              
Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu
    50                  55                  60                  
Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro
65                  70                  75                  80  
Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro
                85                  90                  95      
Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser
            100                 105                 110         


<210> 2
<211> 206
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature  
<222> (1)...(206)
<223> immunoglobulin IgG1 Fc region GenBank AAC82527.1

<400> 2
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
 1               5                  10                  15      
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
            20                  25                  30          
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        35                  40                  45              
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
    50                  55                  60                  
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
65                  70                  75                  80  
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                85                  90                  95      
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            100                 105                 110         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        115                 120                 125             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    130                 135                 140                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
145                 150                 155                 160 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                165                 170                 175     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            180                 185                 190         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        195                 200                 205     


<210> 3
<211> 210
<212> PRT
<213> Canis familiaris

<220> 
<221> misc_feature   
<222> (1)...(210)
<223> immunoglobulin IgG1 Fc region GenBank AF354264.1

<400> 3
Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr
 1               5                  10                  15      
Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu
            20                  25                  30          
Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys
        35                  40                  45              
Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser
    50                  55                  60                  
Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys
65                  70                  75                  80  
Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile
                85                  90                  95      
Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro
            100                 105                 110         
Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys
        115                 120                 125             
Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser
    130                 135                 140                 
Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln
145                 150                 155                 160 
Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp
                165                 170                 175     
Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val Met His
            180                 185                 190         
Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro
        195                 200                 205             
Gly Lys
    210 


<210> 4
<211> 196
<212> PRT
<213> Equus caballus

<220> 
<221> misc_feature   
<222> (1)...(196)
<223> immunoglobulin IgG1 Fc region GenBank AAG01011.1

<400> 4
Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Lys Ile Ser Arg Lys
 1               5                  10                  15      
Pro Glu Val Thr Cys Val Val Val Asp Leu Gly His Asp Asp Pro Asp
            20                  25                  30          
Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu Thr His Thr Ala Thr
        35                  40                  45              
Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    50                  55                  60                  
Val Leu Pro Ile Gln His Gln Asp Trp Leu Phe Gly Lys Glu Phe Lys
65                  70                  75                  80  
Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro Val Glu Arg Thr Thr
                85                  90                  95      
Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln Val Tyr Val Leu Ala
            100                 105                 110         
Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val Ser Val Thr Cys Leu
        115                 120                 125             
Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn
    130                 135                 140                 
Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr Thr Pro Ala Gln Leu
145                 150                 155                 160 
Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Glu Thr
                165                 170                 175     
Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys Gly Val Met His Glu
            180                 185                 190         
Ala Leu His Asn
        195     


<210> 5
<211> 209
<212> PRT
<213> Felis catus

<220> 
<221> misc_feature    
<222> (1)...(209)
<223> immunoglobulin IgG1 Fc region GenBank AB016710.1

<400> 5
Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr
 1               5                  10                  15      
Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp
            20                  25                  30          
Val Gln Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys
        35                  40                  45              
Thr Ser Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    50                  55                  60                  
Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys
65                  70                  75                  80  
Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile
                85                  90                  95      
Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro
            100                 105                 110         
Pro Ala Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu
        115                 120                 125             
Ile Lys Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr
    130                 135                 140                 
Gly Gln Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu
145                 150                 155                 160 
Asp Ser Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg
                165                 170                 175     
Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu
            180                 185                 190         
Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly
        195                 200                 205             
Lys
    

