                         SEQUENCE LISTING

<110>  Neurim Pharmaceuticals (1991) Ltd.
       Pinner , Elhanan
       Zisapel, Nava
 
<120>  NEUROPROTECTIVE PEPTIDES

<130>  53555

<150>  US 61/466,966
<151>  2011-03-24

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  A pentapeptide derived from the human V6

<400>  1

Asn Arg Trp His Glu 
1               5   


<210>  2
<211>  39
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse V6 peptide

<400>  2

Pro Asn Ser Thr Ala Glu Ala Ala Ala Thr Gln Gln Glu Thr Trp Phe 
1               5                   10                  15      


Gln Asn Gly Trp Gln Gly Lys Asn Pro Pro Thr Pro Ser Glu Asp Ser 
            20                  25                  30          


His Val Thr Glu Gly Thr Thr 
        35                  


<210>  3
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse V6A peptide

<400>  3

Pro Asn Ser Thr Ala Glu Ala Ala Ala Thr Gln Gln Glu Thr Trp Phe 
1               5                   10                  15      


Gln Asn Gly Trp 
            20  


<210>  4
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse V6A1 peptide

<400>  4

Pro Asn Ser Thr Ala Glu Ala Ala Ala Thr Gln Gln Glu 
1               5                   10              


<210>  5
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse V6A2 peptide

<400>  5

Trp Phe Gln Asn Gly Trp 
1               5       


<210>  6
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse V6B peptide

<400>  6

Thr Pro Ser Glu Asp Ser His Val Thr Glu Gly Thr 
1               5                   10          


<210>  7
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse V6B1 peptide

<400>  7

Thr Pro Ser Glu Asp Ser His 
1               5           


<210>  8
<211>  61
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10 peptide

<400>  8

Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
1               5                   10                  15      


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
            20                  25                  30          


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
        35                  40                  45              


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly 
    50                  55                  60      


<210>  9
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10A peptide

<400>  9

Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
1               5                   10                  15      


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr 
            20                  25              


<210>  10
<211>  33
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10B peptide

<400>  10

Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn 
1               5                   10                  15      


Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly 
            20                  25                  30          


Gly 
    


<210>  11
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10A1 peptide

<400>  11

Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
1               5                   10                  15      


<210>  12
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10A2 peptide

<400>  12

Thr Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr 
1               5                   10                  15  


<210>  13
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10B1 peptide

<400>  13

Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn 
1               5                   10                  15      


Val Asn 
        


<210>  14
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10B2 peptide

<400>  14

Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
1               5                   10                  15      


Phe His Pro Ser Gly 
            20      


<210>  15
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human V10B3 peptide

<400>  15

Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly 
1               5                   10              


<210>  16
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V6B1 peptide

<400>  16

Thr Pro Lys Glu Asp Ser His 
1               5           


<210>  17
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V6B1_C4 peptide

<400>  17

Glu Asp Ser His 
1               


<210>  18
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A/B_L peptide

<400>  18

Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr 
1               5                   10                  15      


Val 
    


<210>  19
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A/B_S peptide

<400>  19

Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A2_C7 peptide

<400>  20

Pro Val Thr Ser Ala Lys Thr 
1               5           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A2_C10 peptide

<400>  21

Thr Phe Ile Pro Val Thr Ser Ala Lys Thr 
1               5                   10  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A1_N12 peptide

<400>  22

Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro 
1               5                   10          


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A1_N8 peptide

<400>  23

Thr Thr Leu Leu Glu Gly Tyr Thr 
1               5               


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A1_N6 peptide

<400>  24

Thr Thr Leu Leu Glu Gly 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A1_N+2_6 peptide

<400>  25

Leu Leu Glu Gly Tyr Thr 
1               5       


<210>  26
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A1_N+4 peptide (also referred to as P26)

<400>  26

Glu Gly Tyr Thr Ser His Tyr Pro 
1               5               


<210>  27
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10A1_EGYT peptide

<400>  27

Glu Gly Tyr Thr 
1               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B3_N7 peptide

<400>  28

Ser Leu Ser Gly Asp Gln Asp Thr 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B3_N6 peptide

<400>  29

Ser Leu Ser Gly Asp Gln Asp 
1               5           


<210>  30
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B3_N5 peptide

<400>  30

Ser Leu Ser Gly Asp 
1               5   


<210>  31
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B2.5_6 peptide

<400>  31

Asn Val Asn Arg Ser Leu 
1               5       


<210>  32
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B2.5_9 peptide

<400>  32

Asn Val Asn Arg Ser Leu Ser Gly Asp 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B2_N10 peptide

<400>  33

Asp Ser Asn Ser Asn Val Asn Arg Ser Leu 
1               5                   10  


<210>  34
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B1_8 peptide (also referred to as P34)

<400>  34

Phe Gly Val Thr Ala Val Thr Val 
1               5               


<210>  35
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human V10B1_7 peptide

<400>  35

Phe Gly Val Thr Ala Val Thr 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-1 peptide

<400>  36

Glu Gly Tyr Thr Ser His Tyr 
1               5           


<210>  37
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-2 peptide

<400>  37

Glu Gly Tyr Thr Ser His 
1               5       


<210>  38
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-3 peptide

<400>  38

Glu Gly Tyr Thr Ser 
1               5   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-4 peptide

<400>  39

Gly Tyr Thr Ser His Tyr Pro 
1               5           


<210>  40
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-5 peptide

<400>  40

Tyr Thr Ser His Tyr Pro 
1               5       


<210>  41
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-6 peptide

<400>  41

Thr Ser His Tyr Pro 
1               5   


<210>  42
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-7 peptide

<400>  42

Gly Tyr Thr Ser His Tyr 
1               5       


<210>  43
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-8 peptide

<400>  43

Gln Gly Tyr Thr Ser His Tyr Pro 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-9 peptide

<400>  44

Glu Gly Tyr Thr Ser Ala Tyr Pro 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-RI peptide


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  D stereoisomer

<400>  45

Pro Tyr His Ser Thr Tyr Gly Glu 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 26-R peptide

<400>  46

Pro Tyr His Ser Thr Tyr Gly Glu 
1               5               


<210>  47
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  A minimal peptide sequence for mediating neuroprotection


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Can be D or L stereoisomer

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X can be  E or Q

<400>  47

Ser Thr Tyr Gly Xaa 
1               5   


<210>  48
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  A control peptide

<400>  48

Ala Val Ala Val Glu Ala Ala Gly 
1               5               


<210>  49
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  An amino acid sequence missing from the CD44V10

<400>  49

Asp Ser Thr Asp Arg Ile Pro Ala Thr Ile Arg Asn Asp Val Thr Gly 
1               5                   10                  15      


Gly Arg Arg 
            


<210>  50
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  An amino acid sequence missing from the CD44V10

<400>  50

Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His 
1               5                   10                  15      


Pro Ser Gly 
            


<210>  51
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  An amino acid sequence missing from the CD44 V6

<400>  51

Asp Ser Thr Asp Arg Ile Pro Ala Thr Ile Gln Ala Thr Pro Ser Ser 
1               5                   10                  15      


Thr Thr Glu 
            


<210>  52
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  An amino acid sequence missing from the CD44 V6

<400>  52

Asp Ser His Ser Thr Thr Gly Thr Ala Gly Asp Gln Asp Thr Phe His 
1               5                   10                  15      


Pro Ser Gly 
            


<210>  53
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  54
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIV TAT protein PTD derived cell penetrating peptide

<400>  54

Tyr Gly Arg Lys Lys Arg Arg 
1               5           


<210>  55
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIV TAT protein PTD derived cell penetrating peptide

<400>  55

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  56
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIV TAT protein PTD derived cell penetrating peptide

<400>  56

Arg Arg Gln Arg Arg 
1               5   


