                         SEQUENCE LISTING

<110>  Medizinische Hochschule Hannover
 
<120>  Immune suppressor and its use

<130>  3096-023-EP-1

<150>  ep11159203
<151>  2011-03-22

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  819
<212>  DNA
<213>  HCMV


<220>
<221>  CDS
<222>  (1)..(816)

<400>  1
atg ctg ttc agg tac atc acc ttt cat cgc gaa aag gta ctt tac cta         48
Met Leu Phe Arg Tyr Ile Thr Phe His Arg Glu Lys Val Leu Tyr Leu           
1               5                   10                  15                

acg gct gca tgc atc ttt ggt ggc tac atc agc ctc cac gat gcc tgc         96
Thr Ala Ala Cys Ile Phe Gly Gly Tyr Ile Ser Leu His Asp Ala Cys           
            20                  25                  30                    

ata ccg gtg gtt ggc aaa ata ggt acc aac gtc acg ttg aac gcg gta        144
Ile Pro Val Val Gly Lys Ile Gly Thr Asn Val Thr Leu Asn Ala Val           
        35                  40                  45                        

gat ttt cat ccc ggt gat cac gtt cgc tgg tct tac ggt ccc ggt ggg        192
Asp Phe His Pro Gly Asp His Val Arg Trp Ser Tyr Gly Pro Gly Gly           
    50                  55                  60                            

gca ggc tac atg cta tgt gtt tac act ggt agt tgg aca gaa tac aaa        240
Ala Gly Tyr Met Leu Cys Val Tyr Thr Gly Ser Trp Thr Glu Tyr Lys           
65                  70                  75                  80            

aag cca gac atc att ttt aag tgt tta tca aat aac agt ctt ctt tta        288
Lys Pro Asp Ile Ile Phe Lys Cys Leu Ser Asn Asn Ser Leu Leu Leu           
                85                  90                  95                

att aac gta act gta aat tat acc aac act tac cgt acc ttg aca tcg        336
Ile Asn Val Thr Val Asn Tyr Thr Asn Thr Tyr Arg Thr Leu Thr Ser           
            100                 105                 110                   

tta aac aat tgg gtt cac aat caa cat cac cat aaa ttt ccc gga tgg        384
Leu Asn Asn Trp Val His Asn Gln His His His Lys Phe Pro Gly Trp           
        115                 120                 125                       

aac ttg gac aca tgt tac agt ctc aca gtg aac gaa aac ggt aca ttc        432
Asn Leu Asp Thr Cys Tyr Ser Leu Thr Val Asn Glu Asn Gly Thr Phe           
    130                 135                 140                           

ccc act acc acc acc aaa aaa ccc act acg acc acg aga acg aca act        480
Pro Thr Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr Arg Thr Thr Thr           
145                 150                 155                 160           

acc acc aca aca aag aaa aca acc acc acg aga aca acc acc gcc gcc        528
Thr Thr Thr Thr Lys Lys Thr Thr Thr Thr Arg Thr Thr Thr Ala Ala           
                165                 170                 175               

aag aag acg acg ata agc act acc cat cat aaa cac tcc agt ccc aaa        576
Lys Lys Thr Thr Ile Ser Thr Thr His His Lys His Ser Ser Pro Lys           
            180                 185                 190                   

aaa tcc agc acc cct aac agt cac gta gaa cat cac gtt ggt ttt gaa        624
Lys Ser Ser Thr Pro Asn Ser His Val Glu His His Val Gly Phe Glu           
        195                 200                 205                       

gcc aca gca gcg gaa aca ccg tta caa cca agc cca cag cac caa cac        672
Ala Thr Ala Ala Glu Thr Pro Leu Gln Pro Ser Pro Gln His Gln His           
    210                 215                 220                           

gtg gct aca cac gcc ctc tgg gtt tta gcg gtc gta atc gtt att atc        720
Val Ala Thr His Ala Leu Trp Val Leu Ala Val Val Ile Val Ile Ile           
225                 230                 235                 240           

atc att atc att ttc tac ttt cga ata ccg caa aag ctg tgg ctg ctc        768
Ile Ile Ile Ile Phe Tyr Phe Arg Ile Pro Gln Lys Leu Trp Leu Leu           
                245                 250                 255               

tgg cag cat gac aag cac ggc atc gtg ctc atc cct caa acc gat ctg        816
Trp Gln His Asp Lys His Gly Ile Val Leu Ile Pro Gln Thr Asp Leu           
            260                 265                 270                   

tga                                                                    819


<210>  2
<211>  272
<212>  PRT
<213>  HCMV

<400>  2

Met Leu Phe Arg Tyr Ile Thr Phe His Arg Glu Lys Val Leu Tyr Leu 
1               5                   10                  15      


Thr Ala Ala Cys Ile Phe Gly Gly Tyr Ile Ser Leu His Asp Ala Cys 
            20                  25                  30          


Ile Pro Val Val Gly Lys Ile Gly Thr Asn Val Thr Leu Asn Ala Val 
        35                  40                  45              


Asp Phe His Pro Gly Asp His Val Arg Trp Ser Tyr Gly Pro Gly Gly 
    50                  55                  60                  


Ala Gly Tyr Met Leu Cys Val Tyr Thr Gly Ser Trp Thr Glu Tyr Lys 
65                  70                  75                  80  


Lys Pro Asp Ile Ile Phe Lys Cys Leu Ser Asn Asn Ser Leu Leu Leu 
                85                  90                  95      


Ile Asn Val Thr Val Asn Tyr Thr Asn Thr Tyr Arg Thr Leu Thr Ser 
            100                 105                 110         


Leu Asn Asn Trp Val His Asn Gln His His His Lys Phe Pro Gly Trp 
        115                 120                 125             


Asn Leu Asp Thr Cys Tyr Ser Leu Thr Val Asn Glu Asn Gly Thr Phe 
    130                 135                 140                 


Pro Thr Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr Arg Thr Thr Thr 
145                 150                 155                 160 


Thr Thr Thr Thr Lys Lys Thr Thr Thr Thr Arg Thr Thr Thr Ala Ala 
                165                 170                 175     


Lys Lys Thr Thr Ile Ser Thr Thr His His Lys His Ser Ser Pro Lys 
            180                 185                 190         


Lys Ser Ser Thr Pro Asn Ser His Val Glu His His Val Gly Phe Glu 
        195                 200                 205             


Ala Thr Ala Ala Glu Thr Pro Leu Gln Pro Ser Pro Gln His Gln His 
    210                 215                 220                 


Val Ala Thr His Ala Leu Trp Val Leu Ala Val Val Ile Val Ile Ile 
225                 230                 235                 240 


Ile Ile Ile Ile Phe Tyr Phe Arg Ile Pro Gln Lys Leu Trp Leu Leu 
                245                 250                 255     


Trp Gln His Asp Lys His Gly Ile Val Leu Ile Pro Gln Thr Asp Leu 
            260                 265                 270         


<210>  3
<211>  606
<212>  DNA
<213>  HCMV


<220>
<221>  CDS
<222>  (1)..(606)

<400>  3
atc agc ctc cac gat gcc tgc ata ccg gtg gtt ggc aaa ata ggt acc         48
Ile Ser Leu His Asp Ala Cys Ile Pro Val Val Gly Lys Ile Gly Thr           
1               5                   10                  15                

aac gtc acg ttg aac gcg gta gat ttt cat ccc ggt gat cac gtt cgc         96
Asn Val Thr Leu Asn Ala Val Asp Phe His Pro Gly Asp His Val Arg           
            20                  25                  30                    

tgg tct tac ggt ccc ggt ggg gca ggc tac atg cta tgt gtt tac act        144
Trp Ser Tyr Gly Pro Gly Gly Ala Gly Tyr Met Leu Cys Val Tyr Thr           
        35                  40                  45                        

ggt agt tgg aca gaa tac aaa aag cca gac atc att ttt aag tgt tta        192
Gly Ser Trp Thr Glu Tyr Lys Lys Pro Asp Ile Ile Phe Lys Cys Leu           
    50                  55                  60                            

tca aat aac agt ctt ctt tta att aac gta act gta aat tat acc aac        240
Ser Asn Asn Ser Leu Leu Leu Ile Asn Val Thr Val Asn Tyr Thr Asn           
65                  70                  75                  80            

act tac cgt acc ttg aca tcg tta aac aat tgg gtt cac aat caa cat        288
Thr Tyr Arg Thr Leu Thr Ser Leu Asn Asn Trp Val His Asn Gln His           
                85                  90                  95                

cac cat aaa ttt ccc gga tgg aac ttg gac aca tgt tac agt ctc aca        336
His His Lys Phe Pro Gly Trp Asn Leu Asp Thr Cys Tyr Ser Leu Thr           
            100                 105                 110                   

gtg aac gaa aac ggt aca ttc ccc act acc acc acc aaa aaa ccc act        384
Val Asn Glu Asn Gly Thr Phe Pro Thr Thr Thr Thr Lys Lys Pro Thr           
        115                 120                 125                       

acg acc acg aga acg aca act acc acc aca aca aag aaa aca acc acc        432
Thr Thr Thr Arg Thr Thr Thr Thr Thr Thr Thr Lys Lys Thr Thr Thr           
    130                 135                 140                           

acg aga aca acc acc gcc gcc aag aag acg acg ata agc act acc cat        480
Thr Arg Thr Thr Thr Ala Ala Lys Lys Thr Thr Ile Ser Thr Thr His           
145                 150                 155                 160           

cat aaa cac tcc agt ccc aaa aaa tcc agc acc cct aac agt cac gta        528
His Lys His Ser Ser Pro Lys Lys Ser Ser Thr Pro Asn Ser His Val           
                165                 170                 175               

gaa cat cac gtt ggt ttt gaa gcc aca gca gcg gaa aca ccg tta caa        576
Glu His His Val Gly Phe Glu Ala Thr Ala Ala Glu Thr Pro Leu Gln           
            180                 185                 190                   

cca agc cca cag cac caa cac gtg gct aca                                606
Pro Ser Pro Gln His Gln His Val Ala Thr                                   
        195                 200                                           


<210>  4
<211>  202
<212>  PRT
<213>  HCMV

<400>  4

Ile Ser Leu His Asp Ala Cys Ile Pro Val Val Gly Lys Ile Gly Thr 
1               5                   10                  15      


Asn Val Thr Leu Asn Ala Val Asp Phe His Pro Gly Asp His Val Arg 
            20                  25                  30          


Trp Ser Tyr Gly Pro Gly Gly Ala Gly Tyr Met Leu Cys Val Tyr Thr 
        35                  40                  45              


Gly Ser Trp Thr Glu Tyr Lys Lys Pro Asp Ile Ile Phe Lys Cys Leu 
    50                  55                  60                  


Ser Asn Asn Ser Leu Leu Leu Ile Asn Val Thr Val Asn Tyr Thr Asn 
65                  70                  75                  80  


Thr Tyr Arg Thr Leu Thr Ser Leu Asn Asn Trp Val His Asn Gln His 
                85                  90                  95      


His His Lys Phe Pro Gly Trp Asn Leu Asp Thr Cys Tyr Ser Leu Thr 
            100                 105                 110         


Val Asn Glu Asn Gly Thr Phe Pro Thr Thr Thr Thr Lys Lys Pro Thr 
        115                 120                 125             


Thr Thr Thr Arg Thr Thr Thr Thr Thr Thr Thr Lys Lys Thr Thr Thr 
    130                 135                 140                 


Thr Arg Thr Thr Thr Ala Ala Lys Lys Thr Thr Ile Ser Thr Thr His 
145                 150                 155                 160 


His Lys His Ser Ser Pro Lys Lys Ser Ser Thr Pro Asn Ser His Val 
                165                 170                 175     


Glu His His Val Gly Phe Glu Ala Thr Ala Ala Glu Thr Pro Leu Gln 
            180                 185                 190         


Pro Ser Pro Gln His Gln His Val Ala Thr 
        195                 200         


<210>  5
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  peptide

<400>  5

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  6
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  6
agtcggatcc aattacctgt ggtagaatgc                                        30


<210>  7
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  7
ggccggatcc ttacgtagaa tcaagaccta                                        30


<210>  8
<211>  56
<212>  DNA
<213>  artificial

<220>
<223>  olionulceotide

<400>  8
aagacaccgg gaccgatcca gcctggatcc gccaccatgc tgttcaggta catcac           56


<210>  9
<211>  50
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide

<400>  9
tatagagtat acaatagtga cgtgggatcc tcacttgtac agctcatcca                  50


<210>  10
<211>  72
<212>  DNA
<213>  artificial

<220>
<223>  olionucleotide

<400>  10
aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg       60

gaccgatcca gc                                                           72


<210>  11
<211>  74
<212>  DNA
<213>  artificial

<220>
<223>  olionucleotide

<400>  11
ggcgtgacac gtttattgag taggattaca gagtataaca tagagtataa tatagagtat       60

acaatagtga cgtg                                                         74


<210>  12
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide

<400>  12
aagacaccgg gaccgatcca gcctggatcc gcccctctcc ctccc                       45


<210>  13
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  13
cgggatccat cagcctccac gatgcctg                                          28


<210>  14
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  14
ccggtcgact gtagccacgt gttggtgc                                          28


<210>  15
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  15
cggcggccgc gccaccatga acttcgggtt c                                      31


<210>  16
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  16
cggaattctc atttacccgg agacaggg                                          28


<210>  17
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
cggcggccgc gccaccatga acttcgggtt c                                      31


<210>  18
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
cggaattctc atttacccgg agacaggg                                          28


<210>  19
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
cgggatccca tgctaagata aacgggtgg                                         29


<210>  20
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
ccggtcgacg aatgccaagt tagttatgtt c                                      31


<210>  21
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
aagacaccgg gaccgatcca gcctggatcc gccaccatga acttcgggtt c                51


<210>  22
<211>  54
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
tatagagtat acaatagtga cgtgggatcc tcatttaccc ggagacaggg agag             54


