                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       UNIVERSITE PARIS-SUD 11
 
<120>  NEW CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM 
       THE CD4 RECEPTOR COUPLED TO A POLYANIONIC POLYPEPTIDE FOR 
       THE TREATMENT OF AIDS

<130>  D29525

<150>  EP 11305309.4
<151>  2011-03-18

<150>  US 61/590,992
<151>  2012-01-26

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  CD4 derived peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  TPA-Asn

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa represents a Bi-phenylalanine

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Val-NH2

<400>  1

Asn Leu His Lys Cys Gln Leu Arg Cys Ser Ser Leu Gly Leu Leu Gly 
1               5                   10                  15      

Arg Cys Ala Gly Ser Xaa Cys Ala Cys Val 
            20                  25      


<210>  2
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  CD4 derived peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  TPA-Asn

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa represents a Bi-phenylalanine

<400>  2

Asn Leu His Lys Cys Gln Leu Arg Cys Ser Ser Leu Gly Leu Leu Gly 
1               5                   10                  15      

Arg Cys Ala Gly Ser Xaa Cys Ala Cys Val 
            20                  25      


<210>  3
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide

<400>  3

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa represents a sulfo tyrosine

<400>  4

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser 
1               5                   10              


<210>  5
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a tyrosine sulfonate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a tyrosine sulfonate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a tyrosine sulfonate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a tyrosine sulfonate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a tyrosine sulfonate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa represents a tyrosine sulfonate

<400>  5

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa represents a p-Carboxymethyl Phe

<400>  6

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser 
1               5                   10              


<210>  7
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa represents a Aminosuberic acid

<400>  7

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Phe Xaa Phe Asp Xaa Ser 
1               5                   10                  


<210>  8
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide

<400>  8

Ser Tyr Asp Tyr Ser Tyr Asp Tyr Ser Tyr Asp Tyr Ser 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide

<400>  9

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Xaa represents a sulfo tyrosine

<400>  10

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Xaa represents a tyrosine sulfonate

<400>  11

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Xaa represents a Aminosuberic acid

<400>  12

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Xaa represents a p-Carboxymethyl Phe

<400>  13

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  NH2-(CH2)3-CO-Ser

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa represents a sulfo tyrosine

<400>  14

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  NH2-(CH2)3-CO-Ser

<400>  15

Ser Tyr Asp Tyr Ser Tyr Asp Tyr Ser Tyr Asp Tyr Ser 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  NH2-(CH2)3-CO-Ser

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a p-Carboxymethyl Phe

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa represents a p-Carboxymethyl Phe

<400>  16

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser 
1               5                   10              


<210>  17
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  NH2-(CH2)3-CO-Ser

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a Aminosuberic acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa represents a Aminosuberic acid

<400>  17

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Phe Xaa Phe Asp Xaa Ser 
1               5                   10                  


<210>  18
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  NH2-(CH2)3-CO-Glu

<400>  18

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is selected from the group consisting of: tyrosine, 
       sulfotyrosine, tyrosine sulfonate , aminosuberic acid, and 
       p-carboxymethyl phenylalanine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is selected from the group consisting of: tyrosine, 
       sulfotyrosine, tyrosine sulfonate , aminosuberic acid, and 
       p-carboxymethyl phenylalanine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is selected from the group consisting of: tyrosine, 
       sulfotyrosine, tyrosine sulfonate , aminosuberic acid, and 
       p-carboxymethyl phenylalanine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is selected from the group consisting of: tyrosine, 
       sulfotyrosine, tyrosine sulfonate , aminosuberic acid, and 
       p-carboxymethyl phenylalanine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is selected from the group consisting of: tyrosine, 
       sulfotyrosine, tyrosine sulfonate , aminosuberic acid, and 
       p-carboxymethyl phenylalanine

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is selected from the group consisting of: tyrosine, 
       sulfotyrosine, tyrosine sulfonate , aminosuberic acid, and 
       p-carboxymethyl phenylalanine

<400>  19

Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser Xaa Asp Xaa Ser 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anionic polypeptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa represents a sulfo tyrosine

<400>  20

Ser Xaa Asp Xaa Ser Xaa Asp Tyr Ser Tyr Asp Tyr Ser 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anionic polypeptide


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa represents a sulfo tyrosine

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa represents a sulfo tyrosine

<400>  21

Ser Tyr Asp Tyr Ser Tyr Asp Xaa Ser Xaa Asp Xaa Ser 
1               5                   10              


