                               SEQUENCE LISTING

<110> THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 
 
<120> MUTATION MIMICKING COMPOUNDS THAT BIND TO THE KINASE DOMAIN OF 
      EGFR 

<130> UPN-5735 (X-5864) 

<140>
<141>

<150> 61,454,083
<151> 2011-03-18

<150> 61/453,626
<151> 2011-03-17

<160> 3     

<170> PatentIn version 3.5

<210> 1
<211> 984
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(984)

<400> 1
agt gga gaa gct ccc aac caa gct ctc ttg agg atc ttg aag gaa act         48
Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr           
1               5                   10                  15                

gaa ttc aaa aag atc aaa gtg ctg ggc tcc ggt gcg ttc ggc acg gtg         96
Glu Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val           
            20                  25                  30                    

tat aag gga ctc tgg atc cca gaa ggt gag aaa gtt aaa att ccc gtc        144
Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val           
        35                  40                  45                        

gct atc aag gaa tta aga gaa gca aca tct ccg aaa gcc aac aag gaa        192
Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu           
    50                  55                  60                            

atc ctc gat gaa gcc tac gtg atg gcc agc gtg gac aac ccc cac gtg        240
Ile Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val           
65                  70                  75                  80            

tgc cgc ctg ctg ggc atc tgc ctc acc tcc acc gtg cag ctc atc acg        288
Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr           
                85                  90                  95                

cag ctc atg ccc ttc ggc tgc ctc ctg gac tat gtc cgg gaa cac aaa        336
Gln Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys           
            100                 105                 110                   

gac aat att ggc tcc cag tac ctg ctc aac tgg tgt gtg cag atc gca        384
Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala           
        115                 120                 125                       

aag ggc atg aac tac ttg gag gac cgt cgc ttg gtg cac cgc gac ctg        432
Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu           
    130                 135                 140                           

gca gcc agg aac gta ctg gtg aaa aca ccg cag cat gtc aag atc aca        480
Ala Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr           
145                 150                 155                 160           

gat ttt ggg ctg gcc aaa ctg ctg ggt gcg gaa gag aaa gaa tac cat        528
Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His           
                165                 170                 175               

gca gaa gga ggc aaa gtg cct atc aag tgg atg gca ttg gaa tca att        576
Ala Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile           
            180                 185                 190                   

tta cac aga atc tat acc cac cag agt gat gtc tgg agc tac ggg gtg        624
Leu His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val           
        195                 200                 205                       

acc gtt tgg gag ttg atg acc ttt gga tcc aag cca tat gac gga atc        672
Thr Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile           
    210                 215                 220                           

cct gcc agc gag atc tcc tcc atc ctg gag aaa gga gaa cgc ctc cct        720
Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro           
225                 230                 235                 240           

cag cca ccc ata tgt acc atc gat gtc tac atg atc atg gtc aag tgc        768
Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys           
                245                 250                 255               

tgg atg ata gac gca gat agt cgc cca aag ttc cgt gag ttg atc atc        816
Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile           
            260                 265                 270                   

gaa ttc tcc aaa atg gcc cga gac ccc cag cgc tac ctt gtc att cag        864
Glu Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln           
        275                 280                 285                       

ggg gat gaa aga atg cat ttg cca agt cct aca gac tcc aac ttc tac        912
Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr           
    290                 295                 300                           

cgt gcc ctg atg gat gaa gaa gac atg gac gac gtg gtg gat gcc gac        960
Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp           
305                 310                 315                 320           

gag tac ctc atc cca cag cag ggc                                        984
Glu Tyr Leu Ile Pro Gln Gln Gly                                           
                325                                                       


<210> 2
<211> 328
<212> PRT
<213> Homo sapiens

<400> 2
Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr 
1               5                   10                  15      


Glu Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
            20                  25                  30          


Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val 
        35                  40                  45              


Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu 
    50                  55                  60                  


Ile Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val 
65                  70                  75                  80  


Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr 
                85                  90                  95      


Gln Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys 
            100                 105                 110         


Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala 
        115                 120                 125             


Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu 
    130                 135                 140                 


Ala Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr 
145                 150                 155                 160 


Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His 
                165                 170                 175     


Ala Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
            180                 185                 190         


Leu His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
        195                 200                 205             


Thr Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile 
    210                 215                 220                 


Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro 
225                 230                 235                 240 


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
                245                 250                 255     


Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile 
            260                 265                 270         


Glu Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln 
        275                 280                 285             


Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr 
    290                 295                 300                 


Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp 
305                 310                 315                 320 


Glu Tyr Leu Ile Pro Gln Gln Gly 
                325             


<210> 3
<211> 328
<212> PRT
<213> Homo sapiens

<400> 3
Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr 
1               5                   10                  15      


Glu Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
            20                  25                  30          


Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val 
        35                  40                  45              


Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu 
    50                  55                  60                  


Ile Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val 
65                  70                  75                  80  


Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr 
                85                  90                  95      


Gln Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys 
            100                 105                 110         


Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala 
        115                 120                 125             


Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu 
    130                 135                 140                 


Ala Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr 
145                 150                 155                 160 


Asp Phe Gly Arg Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His 
                165                 170                 175     


Ala Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
            180                 185                 190         


Leu His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
        195                 200                 205             


Thr Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile 
    210                 215                 220                 


Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro 
225                 230                 235                 240 


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
                245                 250                 255     


Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile 
            260                 265                 270         


Glu Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln 
        275                 280                 285             


Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr 
    290                 295                 300                 


Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp 
305                 310                 315                 320 


Glu Tyr Leu Ile Pro Gln Gln Gly 
                325             



