                         SEQUENCE LISTING

<110>  University of Utah Research Foundation
       Hagemen, Gregory
       Haas, Pulina
       Fleckenstein, Monika
       Pappas, Christian  M.
       Silvestri, Giuliana
       Guymer, Robin
 
<120>  METHODS OF DIAGNOSING AND TREATING VASCULAR ASSOCIATED 
       MACULOPATHY AND SYMPTOMS THEREOF

<130>  21101.0226P1

<150>  61/452,944
<151>  2011-03-15

<150>  61/452,964
<151>  2011-03-15

<150>  61/452,950
<151>  2011-03-15

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  1

Glu Pro Ala Arg Ser Pro Pro Gln Pro Glu His Cys Glu Gly 
1               5                   10                  


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  2

Pro Ala Ser Ala Thr Val Arg Arg Arg Ala Gln Cys 
1               5                   10          


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  3

Ser Arg Arg Ser Glu Arg Leu His Arg Pro Pro Val Ile Cys 
1               5                   10                  


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  4

Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu 
1               5                   10      


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  5

Cys Gly Gln Gly Gln Glu Asp Pro Asn Ser Leu Arg His Lys 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  6

Ser His Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Cys 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  7

Cys Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn 
1               5                   10                  


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  8

Leu Asp Pro Gly Val Gly Gly Glu Gly Ala Ser Asp Lys Gln Arg Ser 
1               5                   10                  15      


Lys Cys 
        


<210>  9
<211>  1450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  9
atggtaccat atgcagattc cgcgtgcagc actgctgcca ctgttactgc tgctgctggc       60

cgcaccggcg agcgcgcaac tgtctcgtgc gggtcgtagc gcaccgctgg cagcgggttg      120

tccggatcgt tgcgaaccgg cgcgttgtcc gccgcagccg gaacattgcg aaggcggtcg      180

tgcgcgtgat gcgtgcggct gctgcgaagt ttgcggtgcg ccggaaggtg cggcgtgtgg      240

cctgcaagaa ggcccgtgcg gtgaaggtct gcaatgcgtg gtgccgtttg gtgttccggc      300

gtctgccacc gttcgtcgtc gtgcgcaggc gggtctgtgt gtgtgcgcga gcagcgaacc      360

ggtgtgcggc agcgatgcga acacctatgc gaacctgtgc caactgcgtg ctgcgagccg      420

tcgtagcgaa cgtctgcatc gtccgccggt gattgtgctg caacgtggcg cgtgtggtca      480

gggccaggaa gatccgaaca gcctgcgtca taaatataac tttatcgcgg atgtggtgga      540

aaaaattgca ccggcggtgg tgcatattga actgtttcgc aaactgccgt ttagcaaacg      600

tgaagtgccg gtggcgagcg gcagcggctt tattgtgagc gaagatggcc tgattgtgac      660

caacgcgcat gtggtgacca acaaacatcg tgtgaaagtg gaactgaaaa acggcgcgac      720

ctatgaagcg aaaatcaaag atgtggatga aaaagcggat attgcgctga tcaaaattga      780

tcatcagggc aaactgccgg ttctgttact gggccgttct agcgaactgc gtccgggcga      840

atttgtggtg gcgattggca gcccgtttag cctgcaaaac accgtgacca ccggcattgt      900

gagcaccacc cagcgtggcg gcaaagaact gggcctgcgt aacagcgata tggattacat      960

tcagaccgat gcgattatta actatggcaa cgcgggcggt ccgctggtga acctggatgg     1020

cgaagtgatt ggcattaaca ccctgaaagt gaccgcgggc attagcttcg cgattccgag     1080

cgataaaatc aaaaaattcc tgaccgaaag ccatgatcgt caggcgaaag gcaaagcgat     1140

caccaaaaaa aaatacatcg gcatccgtat gatgagcctg accagcagca aagcgaaaga     1200

actgaaagat cgtcatcgtg attttccgga tgtgattagc ggcgcgtata ttattgaagt     1260

gattccggat actccggcgg aagcgggcgg tctgaaagaa aacgatgtga tcattagcat     1320

taacggccag agcgtggtga gcgcgaacga tgtgagcgat gtgattaaac gtgaaagcac     1380

cctgaacatg gtggtgcgtc gtggcaacga agatattatg attaccgtga tcccggaaga     1440

aattgatccg                                                            1450


<210>  10
<211>  7083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  10
tacgtagagc agaaactcat ctctgaagag gatctgcatc accatcacca tcactagtga       60

tccgttcaac tagcagacca ttatcaacaa aatactccaa ttggcgatgg ccctgtcctt      120

ttaccagaca accattacct gtcgacacaa tctgcccttt ccaaagatcc caacgaaaag      180

cgtgaccaca tggtccttct tgagtttgta actgctgctg ggattacaca tggcatggat      240

gagctctaca aataatgaat taaacccgct gatcagcctc gactgtgcct tctagttgcc      300

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca      360

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta      420

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc      480

atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcta      540

gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      600

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      660

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      720

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      780

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      840

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      900

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      960

aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt gtggaaagtc     1020

cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccag     1080

gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta     1140

gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc     1200

cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc     1260

ctctgcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc taggcttttg     1320

caaaaagctc ccgggagctt gtatatccat tttcggatct gatcaagaga caggatgagg     1380

atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga     1440

gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt     1500

ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct     1560

gaatgaactg caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg     1620

cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt     1680

gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc     1740

tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc     1800

gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga     1860

tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg     1920

catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat     1980

ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg     2040

ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc     2100

tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta     2160

tcgccttctt gacgagttct tctgagcggg actctggggt tcgcgaaatg accgaccaag     2220

cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg     2280

gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc     2340

tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca     2400

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt     2460

ccaaactcat caatgtatct tatcatgtct gtataccgac gacctctagc tagagcttgg     2520

cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca     2580

acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca     2640

cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc     2700

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt     2760

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact     2820

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag     2880

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     2940

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     3000

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     3060

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     3120

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     3180

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     3240

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     3300

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     3360

gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     3420

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     3480

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     3540

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     3600

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     3660

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     3720

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa     3780

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac     3840

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa     3900

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag     3960

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg     4020

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag     4080

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg     4140

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc     4200

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat     4260

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata     4320

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa     4380

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca     4440

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc     4500

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc     4560

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg     4620

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac     4680

ctgacgacga cggatcggga gatctcccga tcccctatgg tgcactctca gtacaatctg     4740

ctctgatgcc gcatagttaa gccagtatct gctccctgct tgtgtgttgg aggtcgctga     4800

gtagtgcgcg agcaaaattt aagctacaac aaggcaaggc ttgaccgaca attgcatgaa     4860

gaatctgctt agggttaggc gttttgcgct gcttcgcgat gtacgggcca gatatacgcg     4920

ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag     4980

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc     5040

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg     5100

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca     5160

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc     5220

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt     5280

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata     5340

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt     5400

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca     5460

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctctct ggctaactag     5520

agaacccact gcttactggc ttatcgaaat taatacgact cactataggg agacccaagc     5580

tggctagtta agcttgatca aacaagtttg tacaaaaaag caggcttgga aggagttcga     5640

accatgcaga tcccgcgcgc cgctcttctc ccgctgctgc tgctgctgct ggcggcgccc     5700

gcctcggcgc agctgtcccg ggccggccgc tcggcgcctt tggccgccgg gtgcccagac     5760

cgctgcgagc cggcgcgctg cccgccgcag ccggagcact gcgagggcgg ccgggcccgg     5820

gacgcgtgcg gctgctgcga ggtgtgcggc gcgcccgagg gcgccgcgtg cggcctgcag     5880

gagggcccgt gcggcgaggg gctgcagtgc gtggtgccct tcggggtgcc agcctcggcc     5940

acggtgcggc ggcgcgcgca ggccggcctc tgtgtgtgcg ccagcagcga gccggtgtgc     6000

ggcagcgacg ccaacaccta cgccaacctg tgccagctgc gcgccgccag ccgccgctcc     6060

gagaggctgc accggccgcc ggtcatcgtc ctgcagcgcg gagcctgcgg ccaagggcag     6120

gaagatccca acagtttgcg ccataaatat aactttatcg cggacgtggt ggagaagatc     6180

gcccctgccg tggttcatat cgaattgttt cgcaagcttc cgttttctaa acgagaggtg     6240

ccggtggcta gtgggtctgg gtttattgtg tcggaagatg gactgatcgt gacaaatgcc     6300

cacgtggtga ccaacaagca ccgggtcaaa gttgagctga agaacggtgc cacttacgaa     6360

gccaaaatca aggatgtgga tgagaaagca gacatcgcac tcatcaaaat tgaccaccag     6420

ggcaagctgc ctgtcctgct gcttggccgc tcctcagagc tgcggccggg agagttcgtg     6480

gtcgccatcg gaagcccgtt ttcccttcaa aacacagtca ccaccgggat cgtgagcacc     6540

acccagcgag gcggcaaaga gctggggctc cgcaactcag acatggacta catccagacc     6600

gacgccatca tcaactatgg aaactcggga ggcccgttag taaacctgga cggtgaagtg     6660

attggaatta acactttgaa agtgacagct ggaatctcct ttgcaatccc atctgataag     6720

attaaaaagt tcctcacgga gtcccatgac cgacaggcca aaggaaaagc catcaccaag     6780

aagaagtata ttggtatccg aatgatgtca ctcacgtcca gcaaagccaa agagctgaag     6840

gaccggcacc gggacttccc agacgtgatc tcaggagcgt atataattga agtaattcct     6900

gataccccag cagaagctgg tggtctcaag gaaaacgacg tcataatcag catcaatgga     6960

cagtccgtgg tctccgccaa tgatgtcagc gacgtcatta aaagggaaag caccctgaac     7020

atggtggtcc gcaggggtaa tgaagatatc atgatcacag tgattcccga agaaattgac     7080

cca                                                                   7083


<210>  11
<211>  1195
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  11
ctsaatkgag caatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt       60

ttagtgaacc gtcagaattt tgtaatacga ctcactatag ggcggccgcg aattcgtccc      120

tgtaccctac atgctgcgcc tatacccagg accgatggta actgaggcgg aggggaaagg      180

agggcctgag atggcaagtc tgtcctcctc ggtggttcct gtgtccttca tttccactct      240

gcgagagtct gtgctggacc ctggagttgg tggagaagga gccagtgaca agcagaggag      300

caaactgtct ttatcacact ccatgatccc agctgctaaa atccacactg agctctgctt      360

accagccttc ttctctcctg ctggaaccca gaggaggttc cagcagcctc agcaccacct      420

gacactgtct atcatccaca ctgcagcaag gtgactcgac tctagattgc ggccgcggtc      480

atagctgttt cctgaacaga tcccgggtgg catccctgtg acccctcccc agtgcctctc      540

ctggccctgg aagttgccac tccagtgccc accagccttg tcctaataaa attaagttgc      600

atcattttgt ctgactaggt gtccttctat aatattatgg ggtggagggg ggtggtatgg      660

agcaaggggc aagttgggaa gacaacctgt agggcctgcg gggtctattg ggaaccaagc      720

tggagtgcag tggcacaatc ttggctcact gcaatctccg cctcctgggt tcaagcgatt      780

ctcctgcctc agcctcccga gttgttggga ttccaggcat gcatgaccag gctcagctaa      840

tttttgtttt tttggtagag acggggtttc accatattgg ccaggctggt ctccaactcc      900

taatctcagt gatctaccca ccttggcctc caaattgctg ggattacagg cgtgaaccac      960

tgctccttcc tgtccttctg atttaaaata actatacagc agagacgtca gacaagcata     1020

gctactgtca tgcccacggt gggamattgg tgctgctgca ctgtcctctc atgcgttggg     1080

tccactcata atgctgtgga tgggtaccgg cagcttggct gtgcatgkgt cagtagggtg     1140

gtagtccaag tcgacagcag atgcagcatg gmtttcatta gtcagcaaca gttga          1195


<210>  12
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  12
atgcagatcc cgcgcgccgc tcttctcccg ctgctgctgc tgctgctggc ggcgcccgcc       60

tcggcgcagc tgtcccgggc cggccgctcg gcgcctttgg ccgccgggtg cccagaccgc      120

tgcgagccgg cgcgctgccc gccgcagccg gagcactgcg agggcggccg ggcccgggac      180

gcgtgcggct gctgcgaggt gtgcggcgcg cccgagggcg ccgcgtgcgg cctgcaggag      240

ggcccgtgcg gcgaggggct gcagtgcgtg gtgcccttcg gggtgccagc ctcggccacg      300

gtgcggcggc gcgcgcaggc cggcctctgt gtgtgcgcca gcagcgagcc ggtgtgcggc      360

agcgacgcca acacctacgc caacctgtgc cagctgcgcg ccgccagccg ccgctccgag      420

aggctgcacc ggccgccggt catcgtcctg cagcgcggag cctgcggcca agggcaggaa      480

gatcccaaca gtttgcgcca taaatataac tttatcgcgg acgtggtgga gaagatcgcc      540

cctgccgtgg ttcatatcga attgtttcgc aagcttccgt tttctaaacg agaggtgccg      600

gtggctagtg ggtctgggtt tattgtgtcg gaagatggac tgatcgtgac aaatgcccac      660

gtggtgacca acaagcaccg ggtcaaagtt gagctgaaga acggtgccac ttacgaagcc      720

aaaatcaagg atgtggatga gaaagcagac atcgcactca tcaaaattga ccaccagggc      780

aagctgcctg tcctgctgct tggccgctcc tcagagctgc ggccgggaga gttcgtggtc      840

gccatcggaa gcccgttttc ccttcaaaac acagtcacca ccgggatcgt gagcaccacc      900

cagcgaggcg gcaaagagct ggggctccgc aactcagaca tggactacat ccagaccgac      960

gccatcatca actatggaaa ctcgggaggc ccgttagtaa acctggacgg tgaagtgatt     1020

ggaattaaca ctttgaaagt gacagctgga atctcctttg caatcccatc tgataagatt     1080

aaaaagttcc tcacggagtc ccatgaccga caggccaaag gaaaagccat caccaagaag     1140

aagtatattg gtatccgaat gatgtcactc acgtccagca aagccaaaga gctgaaggac     1200

cggcaccggg acttcccaga cgtgatctca ggagcgtata taattgaagt aattcctgat     1260

accccagcag aagctggtgg tctcaaggaa aacgacgtca taatcagcat caatggacag     1320

tccgtggtct ccgccaatga tgtcagcgac gtcattaaaa gggaaagcac cctgaacatg     1380

gtggtccgca ggggtaatga agatatcatg atcacagtga ttcccgaaga aattgaccca     1440

gctcgaggtc acccattcga acaaaaactc atctcagaag aggatctgaa tatgcatacc     1500

ggtcatcatc accatcacca ttga                                            1524


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = Synthetic Construct

<400>  13

Asp Pro Met Phe Lys Leu 
1               5       


