                         SEQUENCE LISTING

<110>  The Brigham and Women's Hospital, Inc.
       Liu, Brian
       Caiazzo, Robert
       Ure, David
       Nelson, James
 
<120>  Protein Biomarkers for the Diagnosis of Prostate Cancer

<130>  7570/20450PC

<150>  61/453,951
<151>  2011-03-17

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  261
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(261)
<223>  Prostate-specific antigen

<400>  1

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  2
<211>  649
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(649)
<223>  Drebrin

<400>  2

Met Ala Gly Val Ser Phe Ser Gly His Arg Leu Glu Leu Leu Ala Ala 
1               5                   10                  15      


Tyr Glu Glu Val Ile Arg Glu Glu Ser Ala Ala Asp Trp Ala Leu Tyr 
            20                  25                  30          


Thr Tyr Glu Asp Gly Ser Asp Asp Leu Lys Leu Ala Ala Ser Gly Glu 
        35                  40                  45              


Gly Gly Leu Gln Glu Leu Ser Gly His Phe Glu Asn Gln Lys Val Met 
    50                  55                  60                  


Tyr Gly Phe Cys Ser Val Lys Asp Ser Gln Ala Ala Leu Pro Lys Tyr 
65                  70                  75                  80  


Val Leu Ile Asn Trp Val Gly Glu Asp Val Pro Asp Ala Arg Lys Cys 
                85                  90                  95      


Ala Cys Ala Ser His Val Ala Lys Val Ala Glu Phe Phe Gln Gly Val 
            100                 105                 110         


Asp Val Ile Val Asn Ala Ser Ser Val Glu Asp Ile Asp Ala Gly Ala 
        115                 120                 125             


Ile Gly Gln Arg Leu Ser Asn Gly Leu Ala Arg Leu Ser Ser Pro Val 
    130                 135                 140                 


Leu His Arg Leu Arg Leu Arg Glu Asp Glu Asn Ala Glu Pro Val Gly 
145                 150                 155                 160 


Thr Thr Tyr Gln Lys Thr Asp Ala Ala Val Glu Met Lys Arg Ile Asn 
                165                 170                 175     


Arg Glu Gln Phe Trp Glu Gln Ala Lys Lys Glu Glu Glu Leu Arg Lys 
            180                 185                 190         


Glu Glu Glu Arg Lys Lys Ala Leu Asp Glu Arg Leu Arg Phe Glu Gln 
        195                 200                 205             


Glu Arg Met Glu Gln Glu Arg Gln Glu Gln Glu Glu Arg Glu Arg Arg 
    210                 215                 220                 


Tyr Arg Glu Arg Glu Gln Gln Ile Glu Glu His Arg Arg Lys Gln Gln 
225                 230                 235                 240 


Thr Leu Glu Ala Glu Glu Ala Lys Arg Arg Leu Lys Glu Gln Ser Ile 
                245                 250                 255     


Phe Gly Asp His Arg Asp Glu Glu Glu Glu Thr His Met Lys Lys Ser 
            260                 265                 270         


Glu Ser Glu Val Glu Glu Ala Ala Ala Ile Ile Ala Gln Arg Pro Asp 
        275                 280                 285             


Asn Pro Arg Glu Phe Phe Lys Gln Gln Glu Arg Val Ala Ser Ala Ser 
    290                 295                 300                 


Ala Gly Ser Cys Asp Val Pro Ser Pro Phe Asn His Arg Pro Gly Ser 
305                 310                 315                 320 


His Leu Asp Ser His Arg Arg Met Ala Pro Thr Pro Ile Pro Thr Arg 
                325                 330                 335     


Ser Pro Ser Asp Ser Ser Thr Ala Ser Thr Pro Val Ala Glu Gln Ile 
            340                 345                 350         


Glu Arg Ala Leu Asp Glu Val Thr Ser Ser Gln Pro Pro Pro Leu Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Ala Gln Glu Thr Gln Glu Pro Ser Pro Ile Leu 
    370                 375                 380                 


Asp Ser Glu Glu Thr Arg Ala Ala Ala Pro Gln Ala Trp Ala Gly Pro 
385                 390                 395                 400 


Met Glu Glu Pro Pro Gln Ala Gln Ala Pro Pro Arg Gly Pro Gly Ser 
                405                 410                 415     


Pro Ala Glu Asp Leu Met Phe Met Glu Ser Ala Glu Gln Ala Val Leu 
            420                 425                 430         


Ala Ala Pro Val Glu Pro Ala Thr Ala Asp Ala Thr Glu Ile His Asp 
        435                 440                 445             


Ala Ala Asp Thr Ile Glu Thr Asp Thr Ala Thr Ala Asp Thr Thr Val 
    450                 455                 460                 


Ala Asn Asn Val Pro Pro Ala Ala Thr Ser Leu Ile Asp Leu Trp Pro 
465                 470                 475                 480 


Gly Asn Gly Glu Gly Ala Ser Thr Leu Gln Gly Glu Pro Arg Ala Pro 
                485                 490                 495     


Thr Pro Pro Ser Gly Thr Glu Val Thr Leu Ala Glu Val Pro Leu Leu 
            500                 505                 510         


Asp Glu Val Ala Pro Glu Pro Leu Leu Pro Ala Gly Glu Gly Cys Ala 
        515                 520                 525             


Thr Leu Leu Asn Phe Asp Glu Leu Pro Glu Pro Pro Ala Thr Phe Cys 
    530                 535                 540                 


Asp Pro Glu Glu Val Glu Gly Glu Ser Leu Ala Ala Pro Gln Thr Pro 
545                 550                 555                 560 


Thr Leu Pro Ser Ala Leu Glu Glu Leu Glu Gln Glu Gln Glu Pro Glu 
                565                 570                 575     


Pro His Leu Leu Thr Asn Gly Glu Thr Thr Gln Lys Glu Gly Thr Gln 
            580                 585                 590         


Ala Ser Glu Gly Tyr Phe Ser Gln Ser Gln Glu Glu Glu Phe Ala Gln 
        595                 600                 605             


Ser Glu Glu Leu Cys Ala Lys Ala Pro Pro Pro Val Phe Tyr Asn Lys 
    610                 615                 620                 


Pro Pro Glu Ile Asp Ile Thr Cys Trp Asp Ala Asp Pro Val Pro Glu 
625                 630                 635                 640 


Glu Glu Glu Gly Phe Glu Gly Gly Asp 
                645                 


<210>  3
<211>  393
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(393)
<223>  Cellular tumor antigen p53

<400>  3

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  4
<211>  1333
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1333)
<223>  Son of sevenless homolog 1

<400>  4

Met Gln Ala Gln Gln Leu Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ala 
1               5                   10                  15      


Pro Lys Trp Arg Gly Leu Leu Val Pro Ala Leu Lys Lys Val Gln Gly 
            20                  25                  30          


Gln Val His Pro Thr Leu Glu Ser Asn Asp Asp Ala Leu Gln Tyr Val 
        35                  40                  45              


Glu Glu Leu Ile Leu Gln Leu Leu Asn Met Leu Cys Gln Ala Gln Pro 
    50                  55                  60                  


Arg Ser Ala Ser Asp Val Glu Glu Arg Val Gln Lys Ser Phe Pro His 
65                  70                  75                  80  


Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys 
                85                  90                  95      


Arg Lys Arg Arg Asn Pro Leu Ser Leu Pro Val Glu Lys Ile His Pro 
            100                 105                 110         


Leu Leu Lys Glu Val Leu Gly Tyr Lys Ile Asp His Gln Val Ser Val 
        115                 120                 125             


Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu 
    130                 135                 140                 


Val Gly Asn Tyr Val Arg Asn Ile Arg His Tyr Glu Ile Thr Lys Gln 
145                 150                 155                 160 


Asp Ile Lys Val Ala Met Cys Ala Asp Lys Val Leu Met Asp Met Phe 
                165                 170                 175     


His Gln Asp Val Glu Asp Ile Asn Ile Leu Ser Leu Thr Asp Glu Glu 
            180                 185                 190         


Pro Ser Thr Ser Gly Glu Gln Thr Tyr Tyr Asp Leu Val Lys Ala Phe 
        195                 200                 205             


Met Ala Glu Ile Arg Gln Tyr Ile Arg Glu Leu Asn Leu Ile Ile Lys 
    210                 215                 220                 


Val Phe Arg Glu Pro Phe Val Ser Asn Ser Lys Leu Phe Ser Ala Asn 
225                 230                 235                 240 


Asp Val Glu Asn Ile Phe Ser Arg Ile Val Asp Ile His Glu Leu Ser 
                245                 250                 255     


Val Lys Leu Leu Gly His Ile Glu Asp Thr Val Glu Met Thr Asp Glu 
            260                 265                 270         


Gly Ser Pro His Pro Leu Val Gly Ser Cys Phe Glu Asp Leu Ala Glu 
        275                 280                 285             


Glu Leu Ala Phe Asp Pro Tyr Glu Ser Tyr Ala Arg Asp Ile Leu Arg 
    290                 295                 300                 


Pro Gly Phe His Asp Arg Phe Leu Ser Gln Leu Ser Lys Pro Gly Ala 
305                 310                 315                 320 


Ala Leu Tyr Leu Gln Ser Ile Gly Glu Gly Phe Lys Glu Ala Val Gln 
                325                 330                 335     


Tyr Val Leu Pro Arg Leu Leu Leu Ala Pro Val Tyr His Cys Leu His 
            340                 345                 350         


Tyr Phe Glu Leu Leu Lys Gln Leu Glu Glu Lys Ser Glu Asp Gln Glu 
        355                 360                 365             


Asp Lys Glu Cys Leu Lys Gln Ala Ile Thr Ala Leu Leu Asn Val Gln 
    370                 375                 380                 


Ser Gly Met Glu Lys Ile Cys Ser Lys Ser Leu Ala Lys Arg Arg Leu 
385                 390                 395                 400 


Ser Glu Ser Ala Cys Arg Phe Tyr Ser Gln Gln Met Lys Gly Lys Gln 
                405                 410                 415     


Leu Ala Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp 
            420                 425                 430         


Glu Gly Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly 
        435                 440                 445             


Thr Leu Thr Arg Val Gly Ala Lys His Glu Arg His Ile Phe Leu Phe 
    450                 455                 460                 


Asp Gly Leu Met Ile Cys Cys Lys Ser Asn His Gly Gln Pro Arg Leu 
465                 470                 475                 480 


Pro Gly Ala Ser Asn Ala Glu Tyr Arg Leu Lys Glu Lys Phe Phe Met 
                485                 490                 495     


Arg Lys Val Gln Ile Asn Asp Lys Asp Asp Thr Asn Glu Tyr Lys His 
            500                 505                 510         


Ala Phe Glu Ile Ile Leu Lys Asp Glu Asn Ser Val Ile Phe Ser Ala 
        515                 520                 525             


Lys Ser Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu 
    530                 535                 540                 


Gln Tyr Arg Ser Thr Leu Glu Arg Met Leu Asp Val Thr Met Leu Gln 
545                 550                 555                 560 


Glu Glu Lys Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg 
                565                 570                 575     


Phe Ala Glu Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met 
            580                 585                 590         


Gln Pro Lys Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys 
        595                 600                 605             


Leu Ile Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val 
    610                 615                 620                 


Arg Thr Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu 
625                 630                 635                 640 


Leu Ser Leu Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr 
                645                 650                 655     


Glu Ala Asp Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala 
            660                 665                 670         


Glu Leu Lys Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg 
        675                 680                 685             


Val Leu Asn Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe 
    690                 695                 700                 


Glu Arg Asp Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr 
705                 710                 715                 720 


Val Arg Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile 
                725                 730                 735     


Ile Gln Arg Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile 
            740                 745                 750         


Thr Phe Gln Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro 
        755                 760                 765             


Gly His Ile Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile 
    770                 775                 780                 


Ala Arg Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln 
785                 790                 795                 800 


Pro Ser Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile 
                805                 810                 815     


Asn Ser Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr 
            820                 825                 830         


Leu Trp Phe Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg 
        835                 840                 845             


Val Ala Val Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu 
    850                 855                 860                 


Leu Asn Asn Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser 
865                 870                 875                 880 


Ser Pro Val Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg 
                885                 890                 895     


Gln Lys Lys Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr 
            900                 905                 910         


Lys Lys Tyr Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro 
        915                 920                 925             


Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn 
    930                 935                 940                 


Pro Glu Val Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys 
945                 950                 955                 960 


Arg Arg Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn 
                965                 970                 975     


Gln Pro Tyr Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu 
            980                 985                 990         


Asn Leu Asn Pro Met Gly Asn Ser  Met Glu Lys Glu Phe  Thr Asp Tyr 
        995                 1000                 1005             


Leu Phe  Asn Lys Ser Leu Glu  Ile Glu Pro Arg Asn  Pro Lys Pro 
    1010                 1015                 1020             


Leu Pro  Arg Phe Pro Lys Lys  Tyr Ser Tyr Pro Leu  Lys Ser Pro 
    1025                 1030                 1035             


Gly Val  Arg Pro Ser Asn Pro  Arg Pro Gly Thr Met  Arg His Pro 
    1040                 1045                 1050             


Thr Pro  Leu Gln Gln Glu Pro  Arg Lys Ile Ser Tyr  Ser Arg Ile 
    1055                 1060                 1065             


Pro Glu  Ser Glu Thr Glu Ser  Thr Ala Ser Ala Pro  Asn Ser Pro 
    1070                 1075                 1080             


Arg Thr  Pro Leu Thr Pro Pro  Pro Ala Ser Gly Ala  Ser Ser Thr 
    1085                 1090                 1095             


Thr Asp  Val Cys Ser Val Phe  Asp Ser Asp His Ser  Ser Pro Phe 
    1100                 1105                 1110             


His Ser  Ser Asn Asp Thr Val  Phe Ile Gln Val Thr  Leu Pro His 
    1115                 1120                 1125             


Gly Pro  Arg Ser Ala Ser Val  Ser Ser Ile Ser Leu  Thr Lys Gly 
    1130                 1135                 1140             


Thr Asp  Glu Val Pro Val Pro  Pro Pro Val Pro Pro  Arg Arg Arg 
    1145                 1150                 1155             


Pro Glu  Ser Ala Pro Ala Glu  Ser Ser Pro Ser Lys  Ile Met Ser 
    1160                 1165                 1170             


Lys His  Leu Asp Ser Pro Pro  Ala Ile Pro Pro Arg  Gln Pro Thr 
    1175                 1180                 1185             


Ser Lys  Ala Tyr Ser Pro Arg  Tyr Ser Ile Ser Asp  Arg Thr Ser 
    1190                 1195                 1200             


Ile Ser  Asp Pro Pro Glu Ser  Pro Pro Leu Leu Pro  Pro Arg Glu 
    1205                 1210                 1215             


Pro Val  Arg Thr Pro Asp Val  Phe Ser Ser Ser Pro  Leu His Leu 
    1220                 1225                 1230             


Gln Pro  Pro Pro Leu Gly Lys  Lys Ser Asp His Gly  Asn Ala Phe 
    1235                 1240                 1245             


Phe Pro  Asn Ser Pro Ser Pro  Phe Thr Pro Pro Pro  Pro Gln Thr 
    1250                 1255                 1260             


Pro Ser  Pro His Gly Thr Arg  Arg His Leu Pro Ser  Pro Pro Leu 
    1265                 1270                 1275             


Thr Gln  Glu Val Asp Leu His  Ser Ile Ala Gly Pro  Pro Val Pro 
    1280                 1285                 1290             


Pro Arg  Gln Ser Thr Ser Gln  His Ile Pro Lys Leu  Pro Pro Lys 
    1295                 1300                 1305             


Thr Tyr  Lys Arg Glu His Thr  His Pro Ser Met His  Arg Asp Gly 
    1310                 1315                 1320             


Pro Pro  Leu Leu Glu Asn Ala  His Ser Ser 
    1325                 1330             


<210>  5
<211>  408
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(408)
<223>  Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

<400>  5

Met Ser Lys Arg Asp Ile Val Leu Thr Asn Val Thr Val Val Gln Leu 
1               5                   10                  15      


Leu Arg Gln Pro Cys Pro Val Thr Arg Ala Pro Pro Pro Pro Glu Pro 
            20                  25                  30          


Lys Ala Glu Val Glu Pro Gln Pro Gln Pro Glu Pro Thr Pro Val Arg 
        35                  40                  45              


Glu Glu Ile Lys Pro Pro Pro Pro Pro Leu Pro Pro His Pro Ala Thr 
    50                  55                  60                  


Pro Pro Pro Lys Met Val Ser Val Ala Arg Glu Leu Thr Val Gly Ile 
65                  70                  75                  80  


Asn Gly Phe Gly Arg Ile Gly Arg Leu Val Leu Arg Ala Cys Met Glu 
                85                  90                  95      


Lys Gly Val Lys Val Val Ala Val Asn Asp Pro Phe Ile Asp Pro Glu 
            100                 105                 110         


Tyr Met Val Tyr Met Phe Lys Tyr Asp Ser Thr His Gly Arg Tyr Lys 
        115                 120                 125             


Gly Ser Val Glu Phe Arg Asn Gly Gln Leu Val Val Asp Asn His Glu 
    130                 135                 140                 


Ile Ser Val Tyr Gln Cys Lys Glu Pro Lys Gln Ile Pro Trp Arg Ala 
145                 150                 155                 160 


Val Gly Ser Pro Tyr Val Val Glu Ser Thr Gly Val Tyr Leu Ser Ile 
                165                 170                 175     


Gln Ala Ala Ser Asp His Ile Ser Ala Gly Ala Gln Arg Val Val Ile 
            180                 185                 190         


Ser Ala Pro Ser Pro Asp Ala Pro Met Phe Val Met Gly Val Asn Glu 
        195                 200                 205             


Asn Asp Tyr Asn Pro Gly Ser Met Asn Ile Val Ser Asn Ala Ser Cys 
    210                 215                 220                 


Thr Thr Asn Cys Leu Ala Pro Leu Ala Lys Val Ile His Glu Arg Phe 
225                 230                 235                 240 


Gly Ile Val Glu Gly Leu Met Thr Thr Val His Ser Tyr Thr Ala Thr 
                245                 250                 255     


Gln Lys Thr Val Asp Gly Pro Ser Arg Lys Ala Trp Arg Asp Gly Arg 
            260                 265                 270         


Gly Ala His Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala 
        275                 280                 285             


Val Thr Lys Val Ile Pro Glu Leu Lys Gly Lys Leu Thr Gly Met Ala 
    290                 295                 300                 


Phe Arg Val Pro Thr Pro Asp Val Ser Val Val Asp Leu Thr Cys Arg 
305                 310                 315                 320 


Leu Ala Gln Pro Ala Pro Tyr Ser Ala Ile Lys Glu Ala Val Lys Ala 
                325                 330                 335     


Ala Ala Lys Gly Pro Met Ala Gly Ile Leu Ala Tyr Thr Glu Asp Glu 
            340                 345                 350         


Val Val Ser Thr Asp Phe Leu Gly Asp Thr His Ser Ser Ile Phe Asp 
        355                 360                 365             


Ala Lys Ala Gly Ile Ala Leu Asn Asp Asn Phe Val Lys Leu Ile Ser 
    370                 375                 380                 


Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser His Arg Val Val Asp Leu Leu 
385                 390                 395                 400 


Arg Tyr Met Phe Ser Arg Asp Lys 
                405             


<210>  6
<211>  793
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(793)
<223>  Caldesmon

<400>  6

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val 
        195                 200                 205             


Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val 
    210                 215                 220                 


Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln 
225                 230                 235                 240 


Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys 
                245                 250                 255     


Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu 
            260                 265                 270         


Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile 
        275                 280                 285             


Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln 
    290                 295                 300                 


Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu 
305                 310                 315                 320 


Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys 
                325                 330                 335     


Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala 
            340                 345                 350         


Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu 
        355                 360                 365             


Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu 
    370                 375                 380                 


Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys Arg Ala Met Gln 
385                 390                 395                 400 


Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys 
                405                 410                 415     


Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val 
            420                 425                 430         


Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg 
        435                 440                 445             


Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys 
    450                 455                 460                 


Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser 
465                 470                 475                 480 


Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly 
                485                 490                 495     


Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg 
            500                 505                 510         


Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro 
        515                 520                 525             


Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly 
    530                 535                 540                 


Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu 
545                 550                 555                 560 


Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg 
                565                 570                 575     


Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp 
            580                 585                 590         


Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile 
        595                 600                 605             


Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu 
    610                 615                 620                 


Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys 
625                 630                 635                 640 


Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser 
                645                 650                 655     


Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val 
            660                 665                 670         


Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly 
        675                 680                 685             


Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val 
    690                 695                 700                 


Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn 
705                 710                 715                 720 


Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala 
                725                 730                 735     


Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys 
            740                 745                 750         


Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg 
        755                 760                 765             


Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val 
    770                 775                 780                 


Asp Lys Val Thr Ser Pro Thr Lys Val 
785                 790             


<210>  7
<211>  641
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(641)
<223>  Heat shock 70 kDa protein 1A/1B

<400>  7

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  8
<211>  295
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(295)
<223>  G1/S-specific cyclin-D1

<400>  8

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  9
<211>  445
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(445)
<223>  Tubulin beta-2A chain

<400>  9

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ala Gly Asn Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ser Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Ser Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ser Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Ile Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asp Glu 
            420                 425                 430         


Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp Glu Ala 
        435                 440                 445 


<210>  10
<211>  765
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(765)
<223>  DNA topoisomerase 1

<400>  10

Met Ser Gly Asp His Leu His Asn Asp Ser Gln Ile Glu Ala Asp Phe 
1               5                   10                  15      


Arg Leu Asn Asp Ser His Lys His Lys Asp Lys His Lys Asp Arg Glu 
            20                  25                  30          


His Arg His Lys Glu His Lys Lys Glu Lys Asp Arg Glu Lys Ser Lys 
        35                  40                  45              


His Ser Asn Ser Glu His Lys Asp Ser Glu Lys Lys His Lys Glu Lys 
    50                  55                  60                  


Glu Lys Thr Lys His Lys Asp Gly Ser Ser Glu Lys His Lys Asp Lys 
65                  70                  75                  80  


His Lys Asp Arg Asp Lys Glu Lys Arg Lys Glu Glu Lys Val Arg Ala 
                85                  90                  95      


Ser Gly Asp Ala Lys Ile Lys Lys Glu Lys Glu Asn Gly Phe Ser Ser 
            100                 105                 110         


Pro Pro Gln Ile Lys Asp Glu Pro Glu Asp Asp Gly Tyr Phe Val Pro 
        115                 120                 125             


Pro Lys Glu Asp Ile Lys Pro Leu Lys Arg Pro Arg Asp Glu Asp Asp 
    130                 135                 140                 


Ala Asp Tyr Lys Pro Lys Lys Ile Lys Thr Glu Asp Thr Lys Lys Glu 
145                 150                 155                 160 


Lys Lys Arg Lys Leu Glu Glu Glu Glu Asp Gly Lys Leu Lys Lys Pro 
                165                 170                 175     


Lys Asn Lys Asp Lys Asp Lys Lys Val Pro Glu Pro Asp Asn Lys Lys 
            180                 185                 190         


Lys Lys Pro Lys Lys Glu Glu Glu Gln Lys Trp Lys Trp Trp Glu Glu 
        195                 200                 205             


Glu Arg Tyr Pro Glu Gly Ile Lys Trp Lys Phe Leu Glu His Lys Gly 
    210                 215                 220                 


Pro Val Phe Ala Pro Pro Tyr Glu Pro Leu Pro Glu Asn Val Lys Phe 
225                 230                 235                 240 


Tyr Tyr Asp Gly Lys Val Met Lys Leu Ser Pro Lys Ala Glu Glu Val 
                245                 250                 255     


Ala Thr Phe Phe Ala Lys Met Leu Asp His Glu Tyr Thr Thr Lys Glu 
            260                 265                 270         


Ile Phe Arg Lys Asn Phe Phe Lys Asp Trp Arg Lys Glu Met Thr Asn 
        275                 280                 285             


Glu Glu Lys Asn Ile Ile Thr Asn Leu Ser Lys Cys Asp Phe Thr Gln 
    290                 295                 300                 


Met Ser Gln Tyr Phe Lys Ala Gln Thr Glu Ala Arg Lys Gln Met Ser 
305                 310                 315                 320 


Lys Glu Glu Lys Leu Lys Ile Lys Glu Glu Asn Glu Lys Leu Leu Lys 
                325                 330                 335     


Glu Tyr Gly Phe Cys Ile Met Asp Asn His Lys Glu Arg Ile Ala Asn 
            340                 345                 350         


Phe Lys Ile Glu Pro Pro Gly Leu Phe Arg Gly Arg Gly Asn His Pro 
        355                 360                 365             


Lys Met Gly Met Leu Lys Arg Arg Ile Met Pro Glu Asp Ile Ile Ile 
    370                 375                 380                 


Asn Cys Ser Lys Asp Ala Lys Val Pro Ser Pro Pro Pro Gly His Lys 
385                 390                 395                 400 


Trp Lys Glu Val Arg His Asp Asn Lys Val Thr Trp Leu Val Ser Trp 
                405                 410                 415     


Thr Glu Asn Ile Gln Gly Ser Ile Lys Tyr Ile Met Leu Asn Pro Ser 
            420                 425                 430         


Ser Arg Ile Lys Gly Glu Lys Asp Trp Gln Lys Tyr Glu Thr Ala Arg 
        435                 440                 445             


Arg Leu Lys Lys Cys Val Asp Lys Ile Arg Asn Gln Tyr Arg Glu Asp 
    450                 455                 460                 


Trp Lys Ser Lys Glu Met Lys Val Arg Gln Arg Ala Val Ala Leu Tyr 
465                 470                 475                 480 


Phe Ile Asp Lys Leu Ala Leu Arg Ala Gly Asn Glu Lys Glu Glu Gly 
                485                 490                 495     


Glu Thr Ala Asp Thr Val Gly Cys Cys Ser Leu Arg Val Glu His Ile 
            500                 505                 510         


Asn Leu His Pro Glu Leu Asp Gly Gln Glu Tyr Val Val Glu Phe Asp 
        515                 520                 525             


Phe Leu Gly Lys Asp Ser Ile Arg Tyr Tyr Asn Lys Val Pro Val Glu 
    530                 535                 540                 


Lys Arg Val Phe Lys Asn Leu Gln Leu Phe Met Glu Asn Lys Gln Pro 
545                 550                 555                 560 


Glu Asp Asp Leu Phe Asp Arg Leu Asn Thr Gly Ile Leu Asn Lys His 
                565                 570                 575     


Leu Gln Asp Leu Met Glu Gly Leu Thr Ala Lys Val Phe Arg Thr Tyr 
            580                 585                 590         


Asn Ala Ser Ile Thr Leu Gln Gln Gln Leu Lys Glu Leu Thr Ala Pro 
        595                 600                 605             


Asp Glu Asn Ile Pro Ala Lys Ile Leu Ser Tyr Asn Arg Ala Asn Arg 
    610                 615                 620                 


Ala Val Ala Ile Leu Cys Asn His Gln Arg Ala Pro Pro Lys Thr Phe 
625                 630                 635                 640 


Glu Lys Ser Met Met Asn Leu Gln Thr Lys Ile Asp Ala Lys Lys Glu 
                645                 650                 655     


Gln Leu Ala Asp Ala Arg Arg Asp Leu Lys Ser Ala Lys Ala Asp Ala 
            660                 665                 670         


Lys Val Met Lys Asp Ala Lys Thr Lys Lys Val Val Glu Ser Lys Lys 
        675                 680                 685             


Lys Ala Val Gln Arg Leu Glu Glu Gln Leu Met Lys Leu Glu Val Gln 
    690                 695                 700                 


Ala Thr Asp Arg Glu Glu Asn Lys Gln Ile Ala Leu Gly Thr Ser Lys 
705                 710                 715                 720 


Leu Asn Tyr Leu Asp Pro Arg Ile Thr Val Ala Trp Cys Lys Lys Trp 
                725                 730                 735     


Gly Val Pro Ile Glu Lys Ile Tyr Asn Lys Thr Gln Arg Glu Lys Phe 
            740                 745                 750         


Ala Trp Ala Ile Asp Met Ala Asp Glu Asp Tyr Glu Phe 
        755                 760                 765 


<210>  11
<211>  919
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(919)
<223>  Androgen receptor

<400>  11

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
65                  70                  75                  80  


Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln 
                85                  90                  95      


Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln 
            100                 105                 110         


Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu Arg Gly 
        115                 120                 125             


Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro 
    130                 135                 140                 


Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser 
                165                 170                 175     


Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu 
            180                 185                 190         


Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg 
        195                 200                 205             


Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu 
    210                 215                 220                 


Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys Lys Ala 
225                 230                 235                 240 


Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser 
                245                 250                 255     


Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly 
            260                 265                 270         


Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys 
        275                 280                 285             


Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr 
    290                 295                 300                 


Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly 
305                 310                 315                 320 


Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr 
                325                 330                 335     


Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp 
            340                 345                 350         


Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala 
        355                 360                 365             


Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg 
    370                 375                 380                 


Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly 
                405                 410                 415     


Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser 
            420                 425                 430         


Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro Tyr 
465                 470                 475                 480 


Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp Phe 
                485                 490                 495     


Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val Pro 
            500                 505                 510         


Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met Asp 
        515                 520                 525             


Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp 
    530                 535                 540                 


His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu 
545                 550                 555                 560 


Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys 
                565                 570                 575     


Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys 
            580                 585                 590         


Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg 
        595                 600                 605             


Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met 
    610                 615                 620                 


Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln 
625                 630                 635                 640 


Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr 
                645                 650                 655     


Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile 
            660                 665                 670         


Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly 
        675                 680                 685             


His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu 
    690                 695                 700                 


Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys 
705                 710                 715                 720 


Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val 
                725                 730                 735     


Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg 
            740                 745                 750         


Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu 
        755                 760                 765             


Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys 
    770                 775                 780                 


Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr 
785                 790                 795                 800 


Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile 
                805                 810                 815     


Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met 
            820                 825                 830         


Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn 
        835                 840                 845             


Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp 
    850                 855                 860                 


Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu 
865                 870                 875                 880 


Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala 
                885                 890                 895     


Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys 
            900                 905                 910         


Pro Ile Tyr Phe His Thr Gln 
        915                 


<210>  12
<211>  479
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(479)
<223>  Caspase-8

<400>  12

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile 
        195                 200                 205             


Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys 
    210                 215                 220                 


Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 
225                 230                 235                 240 


Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 
                245                 250                 255     


Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr 
            260                 265                 270         


Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Thr 
        275                 280                 285             


Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His 
    290                 295                 300                 


Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys 
305                 310                 315                 320 


Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu 
                325                 330                 335     


Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly 
        355                 360                 365             


Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp 
    370                 375                 380                 


Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu 
385                 390                 395                 400 


Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala 
                405                 410                 415     


Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg 
            420                 425                 430         


Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr 
        435                 440                 445             


Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro 
    450                 455                 460                 


Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
465                 470                 475                 


<210>  13
<211>  432
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(432)
<223>  Cyclin-A2

<400>  13

Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly Ser 
1               5                   10                  15      


Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu Asn 
            20                  25                  30          


Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr Arg Ala 
        35                  40                  45              


Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 
    50                  55                  60                  


Gln Arg Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 
65                  70                  75                  80  


Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 
                85                  90                  95      


Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 
            100                 105                 110         


Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 
        115                 120                 125             


Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 
    130                 135                 140                 


Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp Met 
145                 150                 155                 160 


Ser Ile Ile Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val Pro 
                165                 170                 175     


Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val Lys 
            180                 185                 190         


Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr Asn 
        195                 200                 205             


Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 
    210                 215                 220                 


Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile Asp 
225                 230                 235                 240 


Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 
                245                 250                 255     


Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 
            260                 265                 270         


Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys 
        275                 280                 285             


Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Thr Phe 
    290                 295                 300                 


Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe Leu 
305                 310                 315                 320 


His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 
                325                 330                 335     


Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 
            340                 345                 350         


Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val Thr 
        355                 360                 365             


Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr Leu 
    370                 375                 380                 


Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu Lys 
385                 390                 395                 400 


Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn Ser 
                405                 410                 415     


Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr Leu Asn Leu 
            420                 425                 430         


<210>  14
<211>  189
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(189)
<223>  Protein DJ-1

<400>  14

Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu 
1               5                   10                  15      


Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys 
            20                  25                  30          


Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg 
        35                  40                  45              


Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu 
    50                  55                  60                  


Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln 
65                  70                  75                  80  


Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu 
                85                  90                  95      


Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu 
            100                 105                 110         


Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu 
        115                 120                 125             


Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn 
    130                 135                 140                 


Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr 
145                 150                 155                 160 


Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu 
                165                 170                 175     


Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp 
            180                 185                 


<210>  15
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(326)
<223>  Peroxisome biogenesis factor 10

<400>  15

Met Ala Pro Ala Ala Ala Ser Pro Pro Glu Val Ile Arg Ala Ala Gln 
1               5                   10                  15      


Lys Asp Glu Tyr Tyr Arg Gly Gly Leu Arg Ser Ala Ala Gly Gly Ala 
            20                  25                  30          


Leu His Ser Leu Ala Gly Ala Arg Lys Trp Leu Glu Trp Arg Lys Glu 
        35                  40                  45              


Val Glu Leu Leu Ser Asp Val Ala Tyr Phe Gly Leu Thr Thr Leu Ala 
    50                  55                  60                  


Gly Tyr Gln Thr Leu Gly Glu Glu Tyr Val Ser Ile Ile Gln Val Asp 
65                  70                  75                  80  


Pro Ser Arg Ile His Val Pro Ser Ser Leu Arg Arg Gly Val Leu Val 
                85                  90                  95      


Thr Leu His Ala Val Leu Pro Tyr Leu Leu Asp Lys Ala Leu Leu Pro 
            100                 105                 110         


Leu Glu Gln Glu Leu Gln Ala Asp Pro Asp Ser Gly Arg Pro Leu Gln 
        115                 120                 125             


Gly Ser Leu Gly Pro Gly Gly Arg Gly Cys Ser Gly Ala Arg Arg Trp 
    130                 135                 140                 


Met Arg His His Thr Ala Thr Leu Thr Glu Gln Gln Arg Arg Ala Leu 
145                 150                 155                 160 


Leu Arg Ala Val Phe Val Leu Arg Gln Gly Leu Ala Cys Leu Gln Arg 
                165                 170                 175     


Leu His Val Ala Trp Phe Tyr Ile His Gly Val Phe Tyr His Leu Ala 
            180                 185                 190         


Lys Arg Leu Thr Gly Ile Thr Tyr Leu Arg Val Arg Ser Leu Pro Gly 
        195                 200                 205             


Glu Asp Leu Arg Ala Arg Val Ser Tyr Arg Leu Leu Gly Val Ile Ser 
    210                 215                 220                 


Leu Leu His Leu Val Leu Ser Met Gly Leu Gln Leu Tyr Gly Phe Arg 
225                 230                 235                 240 


Gln Arg Gln Arg Ala Arg Lys Glu Trp Arg Leu His Arg Gly Leu Ser 
                245                 250                 255     


His Arg Arg Ala Ser Leu Glu Glu Arg Ala Val Ser Arg Asn Pro Leu 
            260                 265                 270         


Cys Thr Leu Cys Leu Glu Glu Arg Arg His Pro Thr Ala Thr Pro Cys 
        275                 280                 285             


Gly His Leu Phe Cys Trp Glu Cys Ile Thr Ala Trp Cys Ser Ser Lys 
    290                 295                 300                 


Ala Glu Cys Pro Leu Cys Arg Glu Lys Phe Pro Pro Gln Lys Leu Ile 
305                 310                 315                 320 


Tyr Leu Arg His Tyr Arg 
                325     


<210>  16
<211>  530
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(530)
<223>  PC4 and SFRS1-interacting protein

<400>  16

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ala Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp His Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Val Asn Leu Lys Val 
                165                 170                 175     


Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys 
            180                 185                 190         


Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu Ser 
        195                 200                 205             


Asp Ile Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu Glu 
    210                 215                 220                 


Lys Gln Pro Lys Lys Gln Pro Lys Lys Asp Glu Glu Gly Gln Lys Glu 
225                 230                 235                 240 


Glu Asp Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu 
                245                 250                 255     


Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser Thr 
            260                 265                 270         


Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys Arg 
        275                 280                 285             


Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu Lys 
    290                 295                 300                 


Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Met Glu Thr Glu Gln Gln Asn Lys Asp Glu Gly Lys Lys Pro Glu 
                325                 330                 335     


Val Lys Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu 
            340                 345                 350         


Gln Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu 
        355                 360                 365             


Asp Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln 
    370                 375                 380                 


Val Thr Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr Leu 
385                 390                 395                 400 


Lys Lys Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser 
                405                 410                 415     


Thr Met Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu Gly 
            420                 425                 430         


Asp Ser Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Arg 
        435                 440                 445             


Gln His Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly Pro 
    450                 455                 460                 


Asn Lys Lys Leu Glu Lys Glu Gln Thr Gly Ser Lys Thr Leu Asn Gly 
465                 470                 475                 480 


Gly Ser Asp Ala Gln Asp Gly Asn Gln Pro Gln His Asn Gly Glu Ser 
                485                 490                 495     


Asn Glu Asp Ser Lys Asp Asn His Glu Ala Ser Thr Lys Lys Lys Pro 
            500                 505                 510         


Ser Ser Glu Glu Arg Glu Thr Glu Ile Ser Leu Lys Asp Ser Thr Leu 
        515                 520                 525             


Asp Asn 
    530 


<210>  17
<211>  403
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(403)
<223>  Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and 
       dual-specificity protein phosphatase PTEN

<400>  17

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  18
<211>  591
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(591)
<223>  Paxillin

<400>  18

Met Asp Asp Leu Asp Ala Leu Leu Ala Asp Leu Glu Ser Thr Thr Ser 
1               5                   10                  15      


His Ile Ser Lys Arg Pro Val Phe Leu Ser Glu Glu Thr Pro Tyr Ser 
            20                  25                  30          


Tyr Pro Thr Gly Asn His Thr Tyr Gln Glu Ile Ala Val Pro Pro Pro 
        35                  40                  45              


Val Pro Pro Pro Pro Ser Ser Glu Ala Leu Asn Gly Thr Ile Leu Asp 
    50                  55                  60                  


Pro Leu Asp Gln Trp Gln Pro Ser Ser Ser Arg Phe Ile His Gln Gln 
65                  70                  75                  80  


Pro Gln Ser Ser Ser Pro Val Tyr Gly Ser Ser Ala Lys Thr Ser Ser 
                85                  90                  95      


Val Ser Asn Pro Gln Asp Ser Val Gly Ser Pro Cys Ser Arg Val Gly 
            100                 105                 110         


Glu Glu Glu His Val Tyr Ser Phe Pro Asn Lys Gln Lys Ser Ala Glu 
        115                 120                 125             


Pro Ser Pro Thr Val Met Ser Thr Ser Leu Gly Ser Asn Leu Ser Glu 
    130                 135                 140                 


Leu Asp Arg Leu Leu Leu Glu Leu Asn Ala Val Gln His Asn Pro Pro 
145                 150                 155                 160 


Gly Phe Pro Ala Asp Glu Ala Asn Ser Ser Pro Pro Leu Pro Gly Ala 
                165                 170                 175     


Leu Ser Pro Leu Tyr Gly Val Pro Glu Thr Asn Ser Pro Leu Gly Gly 
            180                 185                 190         


Lys Ala Gly Pro Leu Thr Lys Glu Lys Pro Lys Arg Asn Gly Gly Arg 
        195                 200                 205             


Gly Leu Glu Asp Val Arg Pro Ser Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Glu Ser Ser Val Pro Ser Pro Val Pro Ala Ile Thr Val Asn Gln Gly 
225                 230                 235                 240 


Glu Met Ser Ser Pro Gln Arg Val Thr Ser Thr Gln Gln Gln Thr Arg 
                245                 250                 255     


Ile Ser Ala Ser Ser Ala Thr Arg Glu Leu Asp Glu Leu Met Ala Ser 
            260                 265                 270         


Leu Ser Asp Phe Lys Ile Gln Gly Leu Glu Gln Arg Ala Asp Gly Glu 
        275                 280                 285             


Arg Cys Trp Ala Ala Gly Trp Pro Arg Asp Gly Gly Arg Ser Ser Pro 
    290                 295                 300                 


Gly Gly Gln Asp Glu Gly Gly Phe Met Ala Gln Gly Lys Thr Gly Ser 
305                 310                 315                 320 


Ser Ser Pro Pro Gly Gly Pro Pro Lys Pro Gly Ser Gln Leu Asp Ser 
                325                 330                 335     


Met Leu Gly Ser Leu Gln Ser Asp Leu Asn Lys Leu Gly Val Ala Thr 
            340                 345                 350         


Val Ala Lys Gly Val Cys Gly Ala Cys Lys Lys Pro Ile Ala Gly Gln 
        355                 360                 365             


Val Val Thr Ala Met Gly Lys Thr Trp His Pro Glu His Phe Val Cys 
    370                 375                 380                 


Thr His Cys Gln Glu Glu Ile Gly Ser Arg Asn Phe Phe Glu Arg Asp 
385                 390                 395                 400 


Gly Gln Pro Tyr Cys Glu Lys Asp Tyr His Asn Leu Phe Ser Pro Arg 
                405                 410                 415     


Cys Tyr Tyr Cys Asn Gly Pro Ile Leu Asp Lys Val Val Thr Ala Leu 
            420                 425                 430         


Asp Arg Thr Trp His Pro Glu His Phe Phe Cys Ala Gln Cys Gly Ala 
        435                 440                 445             


Phe Phe Gly Pro Glu Gly Phe His Glu Lys Asp Gly Lys Ala Tyr Cys 
    450                 455                 460                 


Arg Lys Asp Tyr Phe Asp Met Phe Ala Pro Lys Cys Gly Gly Cys Ala 
465                 470                 475                 480 


Arg Ala Ile Leu Glu Asn Tyr Ile Ser Ala Leu Asn Thr Leu Trp His 
                485                 490                 495     


Pro Glu Cys Phe Val Cys Arg Glu Cys Phe Thr Pro Phe Val Asn Gly 
            500                 505                 510         


Ser Phe Phe Glu His Asp Gly Gln Pro Tyr Cys Glu Val His Tyr His 
        515                 520                 525             


Glu Arg Arg Gly Ser Leu Cys Ser Gly Cys Gln Lys Pro Ile Thr Gly 
    530                 535                 540                 


Arg Cys Ile Thr Ala Met Ala Lys Lys Phe His Pro Glu His Phe Val 
545                 550                 555                 560 


Cys Ala Phe Cys Leu Lys Gln Leu Asn Lys Gly Thr Phe Lys Glu Gln 
                565                 570                 575     


Asn Asp Lys Pro Tyr Cys Gln Asn Cys Phe Leu Lys Leu Phe Cys 
            580                 585                 590     


<210>  19
<211>  414
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(414)
<223>  TAR DNA-binding protein 43

<400>  19

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  20
<211>  2541
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2541)
<223>  Talin-1

<400>  20

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Arg  Glu Gly Ile Ser Gln  Glu Ala Leu 
    1685                 1690                 1695             


His Thr  Gln Met Leu Thr Ala  Val Gln Glu Ile Ser  His Leu Ile 
    1700                 1705                 1710             


Glu Pro  Leu Ala Asn Ala Ala  Arg Ala Glu Ala Ser  Gln Leu Gly 
    1715                 1720                 1725             


His Lys  Val Ser Gln Met Ala  Gln Tyr Phe Glu Pro  Leu Thr Leu 
    1730                 1735                 1740             


Ala Ala  Val Gly Ala Ala Ser  Lys Thr Leu Ser His  Pro Gln Gln 
    1745                 1750                 1755             


Met Ala  Leu Leu Asp Gln Thr  Lys Thr Leu Ala Glu  Ser Ala Leu 
    1760                 1765                 1770             


Gln Leu  Leu Tyr Thr Ala Lys  Glu Ala Gly Gly Asn  Pro Lys Gln 
    1775                 1780                 1785             


Ala Ala  His Thr Gln Glu Ala  Leu Glu Glu Ala Val  Gln Met Met 
    1790                 1795                 1800             


Thr Glu  Ala Val Glu Asp Leu  Thr Thr Thr Leu Asn  Glu Ala Ala 
    1805                 1810                 1815             


Ser Ala  Ala Gly Val Val Gly  Gly Met Val Asp Ser  Ile Thr Gln 
    1820                 1825                 1830             


Ala Ile  Asn Gln Leu Asp Glu  Gly Pro Met Gly Glu  Pro Glu Gly 
    1835                 1840                 1845             


Ser Phe  Val Asp Tyr Gln Thr  Thr Met Val Arg Thr  Ala Lys Ala 
    1850                 1855                 1860             


Ile Ala  Val Thr Val Gln Glu  Met Val Thr Lys Ser  Asn Thr Ser 
    1865                 1870                 1875             


Pro Glu  Glu Leu Gly Pro Leu  Ala Asn Gln Leu Thr  Ser Asp Tyr 
    1880                 1885                 1890             


Gly Arg  Leu Ala Ser Glu Ala  Lys Pro Ala Ala Val  Ala Ala Glu 
    1895                 1900                 1905             


Asn Glu  Glu Ile Gly Ser His  Ile Lys His Arg Val  Gln Glu Leu 
    1910                 1915                 1920             


Gly His  Gly Cys Ala Ala Leu  Val Thr Lys Ala Gly  Ala Leu Gln 
    1925                 1930                 1935             


Cys Ser  Pro Ser Asp Ala Tyr  Thr Lys Lys Glu Leu  Ile Glu Cys 
    1940                 1945                 1950             


Ala Arg  Arg Val Ser Glu Lys  Val Ser His Val Leu  Ala Ala Leu 
    1955                 1960                 1965             


Gln Ala  Gly Asn Arg Gly Thr  Gln Ala Cys Ile Thr  Ala Ala Ser 
    1970                 1975                 1980             


Ala Val  Ser Gly Ile Ile Ala  Asp Leu Asp Thr Thr  Ile Met Phe 
    1985                 1990                 1995             


Ala Thr  Ala Gly Thr Leu Asn  Arg Glu Gly Thr Glu  Thr Phe Ala 
    2000                 2005                 2010             


Asp His  Arg Glu Gly Ile Leu  Lys Thr Ala Lys Val  Leu Val Glu 
    2015                 2020                 2025             


Asp Thr  Lys Val Leu Val Gln  Asn Ala Ala Gly Ser  Gln Glu Lys 
    2030                 2035                 2040             


Leu Ala  Gln Ala Ala Gln Ser  Ser Val Ala Thr Ile  Thr Arg Leu 
    2045                 2050                 2055             


Ala Asp  Val Val Lys Leu Gly  Ala Ala Ser Leu Gly  Ala Glu Asp 
    2060                 2065                 2070             


Pro Glu  Thr Gln Val Val Leu  Ile Asn Ala Val Lys  Asp Val Ala 
    2075                 2080                 2085             


Lys Ala  Leu Gly Asp Leu Ile  Ser Ala Thr Lys Ala  Ala Ala Gly 
    2090                 2095                 2100             


Lys Val  Gly Asp Asp Pro Ala  Val Trp Gln Leu Lys  Asn Ser Ala 
    2105                 2110                 2115             


Lys Val  Met Val Thr Asn Val  Thr Ser Leu Leu Lys  Thr Val Lys 
    2120                 2125                 2130             


Ala Val  Glu Asp Glu Ala Thr  Lys Gly Thr Arg Ala  Leu Glu Ala 
    2135                 2140                 2145             


Thr Thr  Glu His Ile Arg Gln  Glu Leu Ala Val Phe  Cys Ser Pro 
    2150                 2155                 2160             


Glu Pro  Pro Ala Lys Thr Ser  Thr Pro Glu Asp Phe  Ile Arg Met 
    2165                 2170                 2175             


Thr Lys  Gly Ile Thr Met Ala  Thr Ala Lys Ala Val  Ala Ala Gly 
    2180                 2185                 2190             


Asn Ser  Cys Arg Gln Glu Asp  Val Ile Ala Thr Ala  Asn Leu Ser 
    2195                 2200                 2205             


Arg Arg  Ala Ile Ala Asp Met  Leu Arg Ala Cys Lys  Glu Ala Ala 
    2210                 2215                 2220             


Tyr His  Pro Glu Val Ala Pro  Asp Val Arg Leu Arg  Ala Leu His 
    2225                 2230                 2235             


Tyr Gly  Arg Glu Cys Ala Asn  Gly Tyr Leu Glu Leu  Leu Asp His 
    2240                 2245                 2250             


Val Leu  Leu Thr Leu Gln Lys  Pro Ser Pro Glu Leu  Lys Gln Gln 
    2255                 2260                 2265             


Leu Thr  Gly His Ser Lys Arg  Val Ala Gly Ser Val  Thr Glu Leu 
    2270                 2275                 2280             


Ile Gln  Ala Ala Glu Ala Met  Lys Gly Thr Glu Trp  Val Asp Pro 
    2285                 2290                 2295             


Glu Asp  Pro Thr Val Ile Ala  Glu Asn Glu Leu Leu  Gly Ala Ala 
    2300                 2305                 2310             


Ala Ala  Ile Glu Ala Ala Ala  Lys Lys Leu Glu Gln  Leu Lys Pro 
    2315                 2320                 2325             


Arg Ala  Lys Pro Lys Glu Ala  Asp Glu Ser Leu Asn  Phe Glu Glu 
    2330                 2335                 2340             


Gln Ile  Leu Glu Ala Ala Lys  Ser Ile Ala Ala Ala  Thr Ser Ala 
    2345                 2350                 2355             


Leu Val  Lys Ala Ala Ser Ala  Ala Gln Arg Glu Leu  Val Ala Gln 
    2360                 2365                 2370             


Gly Lys  Val Gly Ala Ile Pro  Ala Asn Ala Leu Asp  Asp Gly Gln 
    2375                 2380                 2385             


Trp Ser  Gln Gly Leu Ile Ser  Ala Ala Arg Met Val  Ala Ala Ala 
    2390                 2395                 2400             


Thr Asn  Asn Leu Cys Glu Ala  Ala Asn Ala Ala Val  Gln Gly His 
    2405                 2410                 2415             


Ala Ser  Gln Glu Lys Leu Ile  Ser Ser Ala Lys Gln  Val Ala Ala 
    2420                 2425                 2430             


Ser Thr  Ala Gln Leu Leu Val  Ala Cys Lys Val Lys  Ala Asp Gln 
    2435                 2440                 2445             


Asp Ser  Glu Ala Met Lys Arg  Leu Gln Ala Ala Gly  Asn Ala Val 
    2450                 2455                 2460             


Lys Arg  Ala Ser Asp Asn Leu  Val Lys Ala Ala Gln  Lys Ala Ala 
    2465                 2470                 2475             


Ala Phe  Glu Glu Gln Glu Asn  Glu Thr Val Val Val  Lys Glu Lys 
    2480                 2485                 2490             


Met Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Arg  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Ser  Glu Leu Arg 
    2525                 2530                 2535             


Asp Glu  His 
    2540     


<210>  21
<211>  2000
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2000)
<223>  Chromodomain-helicase-DNA-binding protein 3

<400>  21

Met Lys Ala Ala Asp Thr Val Ile Leu Trp Ala Arg Ser Lys Asn Asp 
1               5                   10                  15      


Gln Leu Arg Ile Ser Phe Pro Pro Gly Leu Cys Trp Gly Asp Arg Met 
            20                  25                  30          


Pro Asp Lys Asp Asp Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys 
        35                  40                  45              


Lys Arg Lys Arg Gly Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys 
    50                  55                  60                  


Pro Arg Lys Arg Lys Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu 
65                  70                  75                  80  


Arg Asp Glu Tyr Arg Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly 
                85                  90                  95      


Thr Gly Pro Gly Arg Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu 
            100                 105                 110         


Lys Lys Thr Lys Arg Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys 
        115                 120                 125             


Gln Val Glu Gln Lys Ser Ser Ala Thr Leu Leu Leu Thr Trp Gly Leu 
    130                 135                 140                 


Glu Asp Val Glu His Val Phe Ser Glu Glu Asp Tyr His Thr Leu Thr 
145                 150                 155                 160 


Asn Tyr Lys Ala Phe Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys 
                165                 170                 175     


Asn Pro Lys Ile Pro Met Ser Lys Met Met Thr Ile Leu Gly Ala Lys 
            180                 185                 190         


Trp Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val 
    210                 215                 220                 


Ser Ala Ala Val Ser Ser Ala Thr Pro Ile Ala Pro Ser Gly Pro Pro 
225                 230                 235                 240 


Ala Leu Pro Pro Pro Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg 
                245                 250                 255     


Arg Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser 
            260                 265                 270         


Lys Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys 
        275                 280                 285             


Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys 
    290                 295                 300                 


Lys Gly Gly Ser Tyr Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu 
305                 310                 315                 320 


Ala Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly 
                325                 330                 335     


Arg Pro Asp Gly Pro Val Arg Thr Lys Lys Leu Lys Arg Gly Arg Pro 
            340                 345                 350         


Gly Arg Lys Lys Lys Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu 
        355                 360                 365             


Glu Glu Val Asp Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val 
    370                 375                 380                 


Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala 
385                 390                 395                 400 


Tyr His Leu Val Cys Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly 
                405                 410                 415     


Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala 
            420                 425                 430         


Lys Glu Glu Glu Glu Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu 
        435                 440                 445             


Lys Glu Glu Glu Asp Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp 
    450                 455                 460                 


Gly Gly Glu Leu Leu Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile 
465                 470                 475                 480 


His Cys Leu Asn Pro Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu 
                485                 490                 495     


Cys Pro Arg Cys Thr Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile 
            500                 505                 510         


Leu His Trp Arg Trp Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln 
        515                 520                 525             


Gln Ala Asp Gly Asn Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly 
    530                 535                 540                 


Arg Ser Glu Arg Glu Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp 
545                 550                 555                 560 


His Cys Ser Trp Ala Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val 
                565                 570                 575     


Met Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro 
            580                 585                 590         


Leu Asp Tyr Gly Ser Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys 
        595                 600                 605             


Val Lys Asp Pro His Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe 
    610                 615                 620                 


Gly Ile Lys Pro Glu Trp Met Thr Val His Arg Ile Ile Asn His Ser 
625                 630                 635                 640 


Val Asp Lys Lys Gly Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu 
                645                 650                 655     


Pro Tyr Asp Gln Ser Thr Trp Glu Glu Asp Glu Met Asn Ile Pro Glu 
            660                 665                 670         


Tyr Glu Glu His Lys Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met 
        675                 680                 685             


Gly Glu Asp Pro Ala Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu 
    690                 695                 700                 


Leu Gln Gly Asp Gly Pro Pro Ser Ser Pro Thr Asn Asp Pro Thr Val 
705                 710                 715                 720 


Lys Tyr Glu Thr Gln Pro Arg Phe Ile Thr Ala Thr Gly Gly Thr Leu 
                725                 730                 735     


His Met Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala 
            740                 745                 750         


Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr 
        755                 760                 765             


Ile Gln Thr Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Thr 
    770                 775                 780                 


Lys Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp 
785                 790                 795                 800 


Glu Arg Glu Phe Gln Met Trp Ala Pro Lys Phe Tyr Val Val Thr Tyr 
                805                 810                 815     


Thr Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser 
            820                 825                 830         


Phe Glu Asp Asn Ala Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys 
        835                 840                 845             


Arg Glu Ala Gln Val Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu 
    850                 855                 860                 


Ile Thr Ile Asp Gln Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu 
865                 870                 875                 880 


Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe 
                885                 890                 895     


Arg Val Leu Asn Gly Tyr Lys Ile Asp His Lys Leu Leu Leu Thr Gly 
            900                 905                 910         


Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe 
        915                 920                 925             


Leu Thr Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe 
    930                 935                 940                 


Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu 
945                 950                 955                 960 


Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met 
                965                 970                 975     


Pro Ala Lys Thr Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln 
            980                 985                 990         


Lys Lys Tyr Tyr Lys Tyr Ile Leu  Thr Arg Asn Phe Glu  Ala Leu Asn 
        995                 1000                 1005             


Ser Arg  Gly Gly Gly Asn Gln  Val Ser Leu Leu Asn  Ile Met Met 
    1010                 1015                 1020             


Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr Leu Phe  Pro Val Ala 
    1025                 1030                 1035             


Ala Met  Glu Ser Pro Lys Leu  Pro Ser Gly Ala Tyr  Glu Gly Gly 
    1040                 1045                 1050             


Ala Leu  Ile Lys Ser Ser Gly  Lys Leu Met Leu Leu  Gln Lys Met 
    1055                 1060                 1065             


Leu Arg  Lys Leu Lys Glu Gln  Gly His Arg Val Leu  Ile Phe Ser 
    1070                 1075                 1080             


Gln Met  Thr Lys Met Leu Asp  Leu Leu Glu Asp Phe  Leu Asp Tyr 
    1085                 1090                 1095             


Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly Gly Ile  Thr Gly Ala 
    1100                 1105                 1110             


Leu Arg  Gln Glu Ala Ile Asp  Arg Phe Asn Ala Pro  Gly Ala Gln 
    1115                 1120                 1125             


Gln Phe  Cys Phe Leu Leu Ser  Thr Arg Ala Gly Gly  Leu Gly Ile 
    1130                 1135                 1140             


Asn Leu  Ala Thr Ala Asp Thr  Val Ile Ile Phe Asp  Ser Asp Trp 
    1145                 1150                 1155             


Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser Arg Ala  His Arg Ile 
    1160                 1165                 1170             


Gly Gln  Ala Asn Lys Val Met  Ile Tyr Arg Phe Val  Thr Arg Ala 
    1175                 1180                 1185             


Ser Val  Glu Glu Arg Ile Thr  Gln Val Ala Lys Arg  Lys Met Met 
    1190                 1195                 1200             


Leu Thr  His Leu Val Val Arg  Pro Gly Leu Gly Ser  Lys Ala Gly 
    1205                 1210                 1215             


Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile Leu Lys  Phe Gly Thr 
    1220                 1225                 1230             


Glu Glu  Leu Phe Lys Asp Glu  Asn Glu Gly Glu Asn  Lys Glu Glu 
    1235                 1240                 1245             


Asp Ser  Ser Val Ile His Tyr  Asp Asn Glu Ala Ile  Ala Arg Leu 
    1250                 1255                 1260             


Leu Asp  Arg Asn Gln Asp Ala  Thr Glu Asp Thr Asp  Val Gln Asn 
    1265                 1270                 1275             


Met Asn  Glu Tyr Leu Ser Ser  Phe Lys Val Ala Gln  Tyr Val Val 
    1280                 1285                 1290             


Arg Glu  Glu Asp Lys Ile Glu  Glu Ile Glu Arg Glu  Ile Ile Lys 
    1295                 1300                 1305             


Gln Glu  Glu Asn Val Asp Pro  Asp Tyr Trp Glu Lys  Leu Leu Arg 
    1310                 1315                 1320             


His His  Tyr Glu Gln Gln Gln  Glu Asp Leu Ala Arg  Asn Leu Gly 
    1325                 1330                 1335             


Lys Gly  Lys Arg Val Arg Lys  Gln Val Asn Tyr Asn  Asp Ala Ala 
    1340                 1345                 1350             


Gln Glu  Asp Gln Asp Asn Gln  Ser Glu Tyr Ser Val  Gly Ser Glu 
    1355                 1360                 1365             


Glu Glu  Asp Glu Asp Phe Asp  Glu Arg Pro Glu Gly  Arg Arg Gln 
    1370                 1375                 1380             


Ser Lys  Arg Gln Leu Arg Asn  Glu Lys Asp Lys Pro  Leu Pro Pro 
    1385                 1390                 1395             


Leu Leu  Ala Arg Val Gly Gly  Asn Ile Glu Val Leu  Gly Phe Asn 
    1400                 1405                 1410             


Thr Arg  Gln Arg Lys Ala Phe  Leu Asn Ala Val Met  Arg Trp Gly 
    1415                 1420                 1425             


Met Pro  Pro Gln Asp Ala Phe  Thr Thr Gln Trp Leu  Val Arg Asp 
    1430                 1435                 1440             


Leu Arg  Gly Lys Thr Glu Lys  Glu Phe Lys Ala Tyr  Val Ser Leu 
    1445                 1450                 1455             


Phe Met  Arg His Leu Cys Glu  Pro Gly Ala Asp Gly  Ser Glu Thr 
    1460                 1465                 1470             


Phe Ala  Asp Gly Val Pro Arg  Glu Gly Leu Ser Arg  Gln Gln Val 
    1475                 1480                 1485             


Leu Thr  Arg Ile Gly Val Met  Ser Leu Val Lys Lys  Lys Val Gln 
    1490                 1495                 1500             


Glu Phe  Glu His Ile Asn Gly  Arg Trp Ser Met Pro  Glu Leu Met 
    1505                 1510                 1515             


Pro Asp  Pro Ser Ala Asp Ser  Lys Arg Ser Ser Arg  Ala Ser Ser 
    1520                 1525                 1530             


Pro Thr  Lys Thr Ser Pro Thr  Thr Pro Glu Ala Ser  Ala Thr Asn 
    1535                 1540                 1545             


Ser Pro  Cys Thr Ser Lys Pro  Ala Thr Pro Ala Pro  Ser Glu Lys 
    1550                 1555                 1560             


Gly Glu  Gly Ile Arg Thr Pro  Leu Glu Lys Glu Glu  Ala Glu Asn 
    1565                 1570                 1575             


Gln Glu  Glu Lys Pro Glu Lys  Asn Ser Arg Ile Gly  Glu Lys Met 
    1580                 1585                 1590             


Glu Thr  Glu Ala Asp Ala Pro  Ser Pro Ala Pro Ser  Leu Gly Glu 
    1595                 1600                 1605             


Arg Leu  Glu Pro Arg Lys Ile  Pro Leu Glu Asp Glu  Val Pro Gly 
    1610                 1615                 1620             


Val Pro  Gly Glu Met Glu Pro  Glu Pro Gly Tyr Arg  Gly Asp Arg 
    1625                 1630                 1635             


Glu Lys  Ser Ala Thr Glu Ser  Thr Pro Gly Glu Arg  Gly Glu Glu 
    1640                 1645                 1650             


Lys Pro  Leu Asp Gly Gln Glu  His Arg Glu Arg Pro  Glu Gly Glu 
    1655                 1660                 1665             


Thr Gly  Asp Leu Gly Lys Arg  Glu Asp Val Lys Gly  Asp Arg Glu 
    1670                 1675                 1680             


Leu Arg  Pro Gly Pro Arg Asp  Glu Pro Arg Ser Asn  Gly Arg Arg 
    1685                 1690                 1695             


Glu Glu  Lys Thr Glu Lys Pro  Arg Phe Met Phe Asn  Ile Ala Asp 
    1700                 1705                 1710             


Gly Gly  Phe Thr Glu Leu His  Thr Leu Trp Gln Asn  Glu Glu Arg 
    1715                 1720                 1725             


Ala Ala  Ile Ser Ser Gly Lys  Leu Asn Glu Ile Trp  His Arg Arg 
    1730                 1735                 1740             


His Asp  Tyr Trp Leu Leu Ala  Gly Ile Val Leu His  Gly Tyr Ala 
    1745                 1750                 1755             


Arg Trp  Gln Asp Ile Gln Asn  Asp Ala Gln Phe Ala  Ile Ile Asn 
    1760                 1765                 1770             


Glu Pro  Phe Lys Thr Glu Ala  Asn Lys Gly Asn Phe  Leu Glu Met 
    1775                 1780                 1785             


Lys Asn  Lys Phe Leu Ala Arg  Arg Phe Lys Leu Leu  Glu Gln Ala 
    1790                 1795                 1800             


Leu Val  Ile Glu Glu Gln Leu  Arg Arg Ala Ala Tyr  Leu Asn Leu 
    1805                 1810                 1815             


Ser Gln  Glu Pro Ala His Pro  Ala Met Ala Leu His  Ala Arg Phe 
    1820                 1825                 1830             


Ala Glu  Ala Glu Cys Leu Ala  Glu Ser His Gln His  Leu Ser Lys 
    1835                 1840                 1845             


Glu Ser  Leu Ala Gly Asn Lys  Pro Ala Asn Ala Val  Leu His Lys 
    1850                 1855                 1860             


Val Leu  Asn Gln Leu Glu Glu  Leu Leu Ser Asp Met  Lys Ala Asp 
    1865                 1870                 1875             


Val Thr  Arg Leu Pro Ala Thr  Leu Ser Arg Ile Pro  Pro Ile Ala 
    1880                 1885                 1890             


Ala Arg  Leu Gln Met Ser Glu  Arg Ser Ile Leu Ser  Arg Leu Ala 
    1895                 1900                 1905             


Ser Lys  Gly Thr Glu Pro His  Pro Thr Pro Ala Tyr  Pro Pro Gly 
    1910                 1915                 1920             


Pro Tyr  Ala Thr Pro Pro Gly  Tyr Gly Ala Ala Phe  Ser Ala Ala 
    1925                 1930                 1935             


Pro Val  Gly Ala Leu Ala Ala  Ala Gly Ala Asn Tyr  Ser Gln Met 
    1940                 1945                 1950             


Pro Ala  Gly Ser Phe Ile Thr  Ala Ala Thr Asn Gly  Pro Pro Val 
    1955                 1960                 1965             


Leu Val  Lys Lys Glu Lys Glu  Met Val Gly Ala Leu  Val Ser Asp 
    1970                 1975                 1980             


Gly Leu  Asp Arg Lys Glu Pro  Arg Ala Gly Glu Val  Ile Cys Ile 
    1985                 1990                 1995             


Asp Asp  
    2000 


<210>  22
<211>  925
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(925)
<223>  Nuclear factor of activated T-cells, cytoplasmic 2

<400>  22

Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 
385                 390                 395                 400 


Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 
                405                 410                 415     


Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 
            420                 425                 430         


Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 
        435                 440                 445             


Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 
    450                 455                 460                 


Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 
465                 470                 475                 480 


Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 
                485                 490                 495     


Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 
            500                 505                 510         


Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 
        515                 520                 525             


Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 
    530                 535                 540                 


Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 
545                 550                 555                 560 


Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 
                565                 570                 575     


Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 
            580                 585                 590         


Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 
        595                 600                 605             


Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 
    610                 615                 620                 


Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 
625                 630                 635                 640 


Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 
                645                 650                 655     


Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 
            660                 665                 670         


Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 
        675                 680                 685             


Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 
    690                 695                 700                 


Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 
705                 710                 715                 720 


Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 
                725                 730                 735     


Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 
            740                 745                 750         


Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 
        755                 760                 765             


Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 
    770                 775                 780                 


Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 
785                 790                 795                 800 


Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 
                805                 810                 815     


Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 
            820                 825                 830         


Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 
        835                 840                 845             


Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 
    850                 855                 860                 


Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 
865                 870                 875                 880 


Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 
                885                 890                 895     


Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Val Asn Glu Ile Ile 
            900                 905                 910         


Arg Lys Glu Phe Ser Gly Pro Pro Ala Arg Asn Gln Thr 
        915                 920                 925 


<210>  23
<211>  255
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(255)
<223>  Syntaxin-6

<400>  23

Met Ser Met Glu Asp Pro Phe Phe Val Val Lys Gly Glu Val Gln Lys 
1               5                   10                  15      


Ala Val Asn Thr Ala Gln Gly Leu Phe Gln Arg Trp Thr Glu Leu Leu 
            20                  25                  30          


Gln Asp Pro Ser Thr Ala Thr Arg Glu Glu Ile Asp Trp Thr Thr Asn 
        35                  40                  45              


Glu Leu Arg Asn Asn Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu 
    50                  55                  60                  


Asp Glu Thr Ile Ser Ile Val Glu Ala Asn Pro Arg Lys Phe Asn Leu 
65                  70                  75                  80  


Asp Ala Thr Glu Leu Ser Ile Arg Lys Ala Phe Ile Thr Ser Thr Arg 
                85                  90                  95      


Gln Val Val Arg Asp Met Lys Asp Gln Met Ser Thr Ser Ser Val Gln 
            100                 105                 110         


Ala Leu Ala Glu Arg Lys Asn Arg Gln Ala Leu Leu Gly Asp Ser Gly 
        115                 120                 125             


Ser Gln Asn Trp Ser Thr Gly Thr Thr Asp Lys Tyr Gly Arg Leu Asp 
    130                 135                 140                 


Arg Glu Leu Gln Arg Ala Asn Ser His Phe Ile Glu Glu Gln Gln Ala 
145                 150                 155                 160 


Gln Gln Gln Leu Ile Val Glu Gln Gln Asp Glu Gln Leu Glu Leu Val 
                165                 170                 175     


Ser Gly Ser Ile Gly Val Leu Lys Asn Met Ser Gln Arg Ile Gly Gly 
            180                 185                 190         


Glu Leu Glu Glu Gln Ala Val Met Leu Glu Asp Phe Ser His Glu Leu 
        195                 200                 205             


Glu Ser Thr Gln Ser Arg Leu Asp Asn Val Met Lys Lys Leu Ala Lys 
    210                 215                 220                 


Val Ser His Met Thr Ser Asp Arg Arg Gln Trp Cys Ala Ile Ala Ile 
225                 230                 235                 240 


Leu Phe Ala Val Leu Leu Val Val Leu Ile Leu Phe Leu Val Leu 
                245                 250                 255 


<210>  24
<211>  636
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(636)
<223>  Tumor protein p73

<400>  24

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Ser 
385                 390                 395                 400 


His Leu Gln Pro Pro Ser Tyr Gly Pro Val Leu Ser Pro Met Asn Lys 
                405                 410                 415     


Val His Gly Gly Met Asn Lys Leu Pro Ser Val Asn Gln Leu Val Gly 
            420                 425                 430         


Gln Pro Pro Pro His Ser Ser Ala Ala Thr Pro Asn Leu Gly Pro Val 
        435                 440                 445             


Gly Pro Gly Met Leu Asn Asn His Gly His Ala Val Pro Ala Asn Gly 
    450                 455                 460                 


Glu Met Ser Ser Ser His Ser Ala Gln Ser Met Val Ser Gly Ser His 
465                 470                 475                 480 


Cys Thr Pro Pro Pro Pro Tyr His Ala Asp Pro Ser Leu Val Ser Phe 
                485                 490                 495     


Leu Thr Gly Leu Gly Cys Pro Asn Cys Ile Glu Tyr Phe Thr Ser Gln 
            500                 505                 510         


Gly Leu Gln Ser Ile Tyr His Leu Gln Asn Leu Thr Ile Glu Asp Leu 
        515                 520                 525             


Gly Ala Leu Lys Ile Pro Glu Gln Tyr Arg Met Thr Ile Trp Arg Gly 
    530                 535                 540                 


Leu Gln Asp Leu Lys Gln Gly His Asp Tyr Ser Thr Ala Gln Gln Leu 
545                 550                 555                 560 


Leu Arg Ser Ser Asn Ala Ala Thr Ile Ser Ile Gly Gly Ser Gly Glu 
                565                 570                 575     


Leu Gln Arg Gln Arg Val Met Glu Ala Val His Phe Arg Val Arg His 
            580                 585                 590         


Thr Ile Thr Ile Pro Asn Arg Gly Gly Pro Gly Gly Gly Pro Asp Glu 
        595                 600                 605             


Trp Ala Asp Phe Gly Phe Asp Leu Pro Asp Cys Lys Ala Arg Lys Gln 
    610                 615                 620                 


Pro Ile Lys Glu Glu Phe Thr Glu Ala Glu Ile His 
625                 630                 635     


<210>  25
<211>  492
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(492)
<223>  Heat shock factor protein 4

<400>  25

Met Gln Glu Ala Pro Ala Ala Leu Pro Thr Glu Pro Gly Pro Ser Pro 
1               5                   10                  15      


Val Pro Ala Phe Leu Gly Lys Leu Trp Ala Leu Val Gly Asp Pro Gly 
            20                  25                  30          


Thr Asp His Leu Ile Arg Trp Ser Pro Ser Gly Thr Ser Phe Leu Val 
        35                  40                  45              


Ser Asp Gln Ser Arg Phe Ala Lys Glu Val Leu Pro Gln Tyr Phe Lys 
    50                  55                  60                  


His Ser Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe 
65                  70                  75                  80  


Arg Lys Val Val Ser Ile Glu Gln Gly Gly Leu Leu Arg Pro Glu Arg 
                85                  90                  95      


Asp His Val Glu Phe Gln His Pro Ser Phe Val Arg Gly Arg Glu Gln 
            100                 105                 110         


Leu Leu Glu Arg Val Arg Arg Lys Val Pro Ala Leu Arg Gly Asp Asp 
        115                 120                 125             


Gly Arg Trp Arg Pro Glu Asp Leu Gly Arg Leu Leu Gly Glu Val Gln 
    130                 135                 140                 


Ala Leu Arg Gly Val Gln Glu Ser Thr Glu Ala Arg Leu Arg Glu Leu 
145                 150                 155                 160 


Arg Gln Gln Asn Glu Ile Leu Trp Arg Glu Val Val Thr Leu Arg Gln 
                165                 170                 175     


Ser His Gly Gln Gln His Arg Val Ile Gly Lys Leu Ile Gln Cys Leu 
            180                 185                 190         


Phe Gly Pro Leu Gln Ala Gly Pro Ser Asn Ala Gly Gly Lys Arg Lys 
        195                 200                 205             


Leu Ser Leu Met Leu Asp Glu Gly Ser Ser Cys Pro Thr Pro Ala Lys 
    210                 215                 220                 


Phe Asn Thr Cys Pro Leu Pro Gly Ala Leu Leu Gln Asp Pro Tyr Phe 
225                 230                 235                 240 


Ile Gln Ser Pro Leu Pro Glu Thr Asn Leu Gly Leu Ser Pro His Arg 
                245                 250                 255     


Ala Arg Gly Pro Ile Ile Ser Asp Ile Pro Glu Asp Ser Pro Ser Pro 
            260                 265                 270         


Glu Gly Thr Arg Leu Ser Pro Ser Ser Asp Gly Arg Arg Glu Lys Gly 
        275                 280                 285             


Leu Ala Leu Leu Lys Glu Glu Pro Ala Ser Pro Gly Gly Asp Gly Glu 
    290                 295                 300                 


Ala Gly Leu Ala Leu Ala Pro Asn Glu Cys Asp Phe Cys Val Thr Ala 
305                 310                 315                 320 


Pro Pro Pro Leu Pro Val Ala Val Val Gln Ala Ile Leu Glu Gly Lys 
                325                 330                 335     


Gly Ser Phe Ser Pro Glu Gly Pro Arg Asn Ala Gln Gln Pro Glu Pro 
            340                 345                 350         


Gly Asp Pro Arg Glu Ile Pro Asp Arg Gly Pro Leu Gly Leu Glu Ser 
        355                 360                 365             


Gly Asp Arg Ser Pro Glu Ser Leu Leu Pro Pro Met Leu Leu Gln Pro 
    370                 375                 380                 


Pro Gln Glu Ser Val Glu Pro Ala Gly Pro Leu Asp Val Leu Gly Pro 
385                 390                 395                 400 


Ser Leu Gln Gly Arg Glu Trp Thr Leu Met Asp Leu Asp Met Glu Leu 
                405                 410                 415     


Ser Leu Met Gln Pro Leu Val Pro Glu Arg Gly Glu Pro Glu Leu Ala 
            420                 425                 430         


Val Lys Gly Leu Asn Ser Pro Ser Pro Gly Lys Asp Pro Thr Leu Gly 
        435                 440                 445             


Ala Pro Leu Leu Leu Asp Val Gln Ala Ala Leu Gly Gly Pro Ala Leu 
    450                 455                 460                 


Gly Leu Pro Gly Ala Leu Thr Ile Tyr Ser Thr Pro Glu Ser Arg Thr 
465                 470                 475                 480 


Ala Ser Tyr Leu Gly Pro Glu Ala Ser Pro Ser Pro 
                485                 490         


<210>  26
<211>  851
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(851)
<223>  Signal transducer and activator of transcription 2

<400>  26

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro 
                85                  90                  95      


Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu 
            100                 105                 110         


Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu 
        115                 120                 125             


Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu 
    130                 135                 140                 


Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val 
145                 150                 155                 160 


Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg 
                165                 170                 175     


Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln 
            180                 185                 190         


Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys 
        195                 200                 205             


Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu 
    210                 215                 220                 


Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala 
225                 230                 235                 240 


Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu 
                245                 250                 255     


Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu 
            260                 265                 270         


Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr 
        275                 280                 285             


Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val 
    290                 295                 300                 


Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr 
305                 310                 315                 320 


Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr 
                325                 330                 335     


Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu 
            340                 345                 350         


Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro 
        355                 360                 365             


Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys 
    370                 375                 380                 


Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe 
385                 390                 395                 400 


Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly 
                405                 410                 415     


Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser 
            420                 425                 430         


Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Thr 
        435                 440                 445             


Asp Thr Leu Pro Val Val Ile Ile Ser Asn Met Asn Gln Leu Ser Ile 
    450                 455                 460                 


Ala Trp Ala Ser Val Leu Trp Phe Asn Leu Leu Ser Pro Asn Leu Gln 
465                 470                 475                 480 


Asn Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu 
                485                 490                 495     


Gly Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu 
            500                 505                 510         


Asn Ser Asp Gln Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn 
        515                 520                 525             


Cys Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg 
    530                 535                 540                 


Glu Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile 
545                 550                 555                 560 


Leu Glu Leu Val His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg 
                565                 570                 575     


Ile Met Gly Phe Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys 
            580                 585                 590         


Thr Met Ser Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly 
        595                 600                 605             


Gly Ile Thr Cys Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu 
    610                 615                 620                 


Ile Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro 
625                 630                 635                 640 


Leu Thr Glu Ile Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile 
                645                 650                 655     


Pro Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu 
            660                 665                 670         


Ala Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg 
        675                 680                 685             


Lys Tyr Leu Lys His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp 
    690                 695                 700                 


Glu Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser 
705                 710                 715                 720 


Leu Glu Leu Glu Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp 
                725                 730                 735     


Leu Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu 
            740                 745                 750         


Ser Val Leu Glu Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys 
        755                 760                 765             


Met Val Ser Gln Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln 
    770                 775                 780                 


Pro Val Pro Glu Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr 
785                 790                 795                 800 


Glu Pro Met Glu Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met 
                805                 810                 815     


Pro Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val 
            820                 825                 830         


Tyr Val Ser Arg Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro 
        835                 840                 845             


Ser Asp Phe 
    850     


<210>  27
<211>  416
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(416)
<223>  Prostate tumor-overexpressed gene 1 protein

<400>  27

Met Val Arg Pro Arg Arg Ala Pro Tyr Arg Ser Gly Ala Gly Gly Pro 
1               5                   10                  15      


Leu Gly Gly Arg Gly Arg Pro Pro Arg Pro Leu Val Val Arg Ala Val 
            20                  25                  30          


Arg Ser Arg Ser Trp Pro Ala Ser Pro Arg Gly Pro Gln Pro Pro Arg 
        35                  40                  45              


Ile Arg Ala Arg Ser Ala Pro Pro Met Glu Gly Ala Arg Val Phe Gly 
    50                  55                  60                  


Ala Leu Gly Pro Ile Gly Pro Ser Ser Pro Gly Leu Thr Leu Gly Gly 
65                  70                  75                  80  


Leu Ala Val Ser Glu His Arg Leu Ser Asn Lys Leu Leu Ala Trp Ser 
                85                  90                  95      


Gly Val Leu Glu Trp Gln Glu Lys Arg Arg Pro Tyr Ser Asp Ser Thr 
            100                 105                 110         


Ala Lys Leu Lys Arg Thr Leu Pro Cys Gln Ala Tyr Val Asn Gln Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Asp Gln Trp Pro Gln Lys Leu Ile Met Gln Leu 
    130                 135                 140                 


Ile Pro Gln Gln Leu Leu Thr Thr Leu Gly Pro Leu Phe Arg Asn Ser 
145                 150                 155                 160 


Gln Leu Ala Gln Phe His Phe Thr Asn Arg Asp Cys Asp Ser Leu Lys 
                165                 170                 175     


Gly Leu Cys Arg Ile Met Gly Asn Gly Phe Ala Gly Cys Met Leu Phe 
            180                 185                 190         


Pro His Ile Ser Pro Cys Glu Val Arg Val Leu Met Leu Leu Tyr Ser 
        195                 200                 205             


Ser Lys Lys Lys Ile Phe Met Gly Leu Ile Pro Tyr Asp Gln Ser Gly 
    210                 215                 220                 


Phe Val Ser Ala Ile Arg Gln Val Ile Thr Thr Arg Lys Gln Ala Val 
225                 230                 235                 240 


Gly Pro Gly Gly Val Asn Ser Gly Pro Val Gln Ile Val Asn Asn Lys 
                245                 250                 255     


Phe Leu Ala Trp Ser Gly Val Met Glu Trp Gln Glu Pro Arg Pro Glu 
            260                 265                 270         


Pro Asn Ser Arg Ser Lys Arg Trp Leu Pro Ser His Val Tyr Val Asn 
        275                 280                 285             


Gln Gly Glu Ile Leu Arg Thr Glu Gln Trp Pro Arg Lys Leu Tyr Met 
    290                 295                 300                 


Gln Leu Ile Pro Gln Gln Leu Leu Thr Thr Leu Val Pro Leu Phe Arg 
305                 310                 315                 320 


Asn Ser Arg Leu Val Gln Phe His Phe Thr Lys Asp Leu Glu Thr Leu 
                325                 330                 335     


Lys Ser Leu Cys Arg Ile Met Asp Asn Gly Phe Ala Gly Cys Val His 
            340                 345                 350         


Phe Ser Tyr Lys Ala Ser Cys Glu Ile Arg Val Leu Met Leu Leu Tyr 
        355                 360                 365             


Ser Ser Glu Lys Lys Ile Phe Ile Gly Leu Ile Pro His Asp Gln Gly 
    370                 375                 380                 


Asn Phe Val Asn Gly Ile Arg Arg Val Ile Ala Asn Gln Gln Gln Val 
385                 390                 395                 400 


Leu Gln Arg Asn Leu Glu Gln Glu Gln Gln Gln Arg Gly Met Gly Gly 
                405                 410                 415     


