                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Almagro, Juan Carlos
       Anderson, Glenn Mark
       Chi, Ellen
       Martinez, Christian
       Raghunathan,Gopalan
       Swanson, Ronald
       Teplyakov, Alexey
       Tse, Kam-Fai
       Wu, Sheng-Jiun
       Zhou, Hong Mimi
 
<120>  Human Tissue Factor Antibody and Uses Thereof

<130>  CEN5309WOPCT

<140>  Unknown
<141>  Herewith

<150>  61/452,674
<151>  2011-03-15

<160>  167   

<170>  PatentIn version 3.5

<210>  1
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
    210                 215                 220                 


Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
225                 230                 235                 240 


Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
                245                 250                 255     


Asn Ser Pro Leu Asn Val Ser 
            260             


<210>  2
<211>  220
<212>  PRT
<213>  Macaca fascicularis

<400>  2

Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Ile Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Ala Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly His Val Glu Ser Thr Gly Ser Thr Glu Glu Pro Pro Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Gln 
        115                 120                 125             


Asp Glu Trp Thr Leu Val Arg Arg Asn Asp Thr Phe Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Arg Thr Ala Asn Arg Lys Ser Thr Asp Ser Pro Val 
        195                 200                 205             


Glu Cys Met Gly His Glu Lys Gly Glu Ser Arg Glu 
    210                 215                 220 


<210>  3
<211>  266
<212>  PRT
<213>  Mus musculus

<400>  3

Ala Gly Ile Pro Glu Lys Ala Phe Asn Leu Thr Trp Ile Ser Thr Asp 
1               5                   10                  15      


Phe Lys Thr Ile Leu Glu Trp Gln Pro Lys Pro Thr Asn Tyr Thr Tyr 
            20                  25                  30          


Thr Val Gln Ile Ser Asp Arg Ser Arg Asn Trp Lys Asn Lys Cys Phe 
        35                  40                  45              


Ser Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp 
    50                  55                  60                  


Val Thr Trp Ala Tyr Glu Ala Lys Val Leu Ser Val Pro Arg Arg Asn 
65                  70                  75                  80  


Ser Val His Gly Asp Gly Asp Gln Leu Val Ile His Gly Glu Glu Pro 
                85                  90                  95      


Pro Phe Thr Asn Ala Pro Lys Phe Leu Pro Tyr Arg Asp Thr Asn Leu 
            100                 105                 110         


Gly Gln Pro Val Ile Gln Gln Phe Glu Gln Asp Gly Arg Lys Leu Asn 
        115                 120                 125             


Val Val Val Lys Asp Ser Leu Thr Leu Val Arg Lys Asn Gly Thr Phe 
    130                 135                 140                 


Leu Thr Leu Arg Gln Val Phe Gly Lys Asp Leu Gly Tyr Ile Ile Thr 
145                 150                 155                 160 


Tyr Arg Lys Gly Ser Ser Thr Gly Lys Lys Thr Asn Ile Thr Asn Thr 
                165                 170                 175     


Asn Glu Phe Ser Ile Asp Val Glu Glu Gly Val Ser Tyr Cys Phe Phe 
            180                 185                 190         


Val Gln Ala Met Ile Phe Ser Arg Lys Thr Asn Gln Asn Ser Pro Gly 
        195                 200                 205             


Ser Ser Thr Val Cys Thr Glu Gln Trp Lys Ser Phe Leu Gly Glu Thr 
    210                 215                 220                 


Leu Ile Ile Val Gly Ala Val Val Leu Leu Ala Thr Ile Phe Ile Ile 
225                 230                 235                 240 


Leu Leu Ser Ile Ser Leu Cys Lys Arg Arg Lys Asn Arg Ala Gly Gln 
                245                 250                 255     


Lys Gly Lys Asn Thr Pro Ser Arg Leu Ala 
            260                 265     


<210>  4
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Ser Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  5
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Ile Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  6
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Tyr Thr Phe Ile Thr Tyr Trp Ile Glu 
1               5                   10  


<210>  7
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
1               5                   10      


<210>  9
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  9

Lys Ser Ser Gln Ser Leu Leu Ser Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  10
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  10

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  11

Gln Asn Asp Tyr Thr Tyr Pro Leu Thr 
1               5                   


<210>  12
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  13
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  14
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  15
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  16
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  17
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  18
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  19
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  19

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  20
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  21
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  22
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr 
            100             


<210>  23
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  23

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr 
            100             


<210>  24
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr 
            100             


<210>  25
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  25

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr 
            100             


<210>  26
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  26

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Leu Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr 
            100             


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Asp Ile Leu Pro Gly Ser Gly Ser Thr Asn 
1               5                   10  


<210>  28
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser 
            20                  25  


<210>  29
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  30
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  31
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  32
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser 
            20                  25  


<210>  33
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  33

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  34
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  34

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  35
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  35

Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly 
1               5                   10                  


<210>  36
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  36

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val Ser 
1               5                   10                  


<210>  37
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  37

Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  38
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  38

His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  39
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  40
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  40

Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  41
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  41

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  42
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  43
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  43

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  44
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  45
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  45

Tyr Ser Pro Ser Phe Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser 
1               5                   10                  15      


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            20                  25                  30          


Ala Met Tyr Tyr Cys Ala Arg 
        35                  


<210>  46
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  46

Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  47
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  47

Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser 
1               5                   10                  15      


Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Thr 
        35                  


<210>  48
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  49
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  50
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  51
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  52
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  52

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  53
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  53

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  54

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  55

Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  56

Trp Leu Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  57
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  58
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  59
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  60
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  60

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  61
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  61

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  62

Gly Tyr Thr Phe Asp Ala His Trp Ile Glu 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  63

Gly Tyr Thr Phe Ile Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  64

Gly Tyr Thr Phe Leu Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  65

Gly Tyr Thr Phe Arg Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  66

Gly Tyr Thr Phe Asn Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  67

Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  68

Gly Tyr Thr Phe Thr Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  69

Gly Tyr Thr Phe Ser Ser His Trp Ile Glu 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  70

Gly Tyr Thr Phe Ser Pro Phe Trp Ile Glu 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  71

Gly Tyr Thr Phe Pro Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  72

Gly Tyr Thr Phe Tyr Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  73

Gly Tyr Thr Phe Pro Thr Tyr Trp Ile Glu 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  74

Gly Tyr Thr Phe Ser Pro His Trp Ile Glu 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  75

Gly Tyr Thr Phe Gly Thr Tyr Trp Ile Glu 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  76

Gly Tyr Thr Phe Ala Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  77

Gly Tyr Thr Phe Val Thr Tyr Trp Ile Glu 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  78

Gly Tyr Thr Phe Gly Pro Phe Trp Ile Glu 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  79

Gly Tyr Thr Phe Ile Pro His Trp Ile Glu 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  80

Gly Tyr Thr Phe Gly Pro His Trp Ile Glu 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  81

Gly Phe Thr Phe Ile Thr Tyr Trp Ile Ala 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  82

Gly Tyr Thr Phe Gly Pro Tyr Trp Ile Glu 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks


<220>
<221>  MUTAGEN
<222>  (5)..(5)
<223>  Xaa is selected from A, D, G, I, L, N, P, R, S, T, V, and Y

<220>
<221>  MUTAGEN
<222>  (6)..(6)
<223>  Xaa is selected from A, P, S, and T

<220>
<221>  MUTAGEN
<222>  (7)..(7)
<223>  Xaa is selected from F, H, and Y

<400>  83

Gly Tyr Thr Phe Xaa Xaa Xaa Trp Ile Glu 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  84

Asp Ile Leu Pro Gly Ser Gly Phe Thr Asp 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  85

Asp Ile Ile Pro Gly Thr Gly Tyr Thr Thr 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  86

Asp Ile Leu Pro Gly Ser Gly Phe Thr Thr 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  87

Asp Ile Ile Pro Gly Thr Gly Phe Thr Asn 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  88

Asp Ile Leu Pro Gly Ser Gly Tyr Thr Thr 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  89

Asp Ile Leu Pro Gly Thr Gly Tyr Thr Leu 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  90

Asp Ile Leu Pro Gly Thr Gly Ala Thr His 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  91

Asp Ile Leu Pro Gly Ser Gly Phe Thr His 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  92

Asp Ile Leu Pro Gly Thr Gly Tyr Thr Trp 
1               5                   10  


<210>  93
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  93

Asp Ile Ile Pro Gly Thr Gly Tyr Thr Asn 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  94

Asp Ile Leu Pro Gly Thr Gly Phe Thr Asn 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  95

Asp Ile Ile Pro Gly Thr Gly Trp Thr Asn 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  96

Asp Ile Leu Pro Gly Ser Gly Tyr Thr Ile 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  97

Asp Ile Leu Pro Gly Thr Gly His Thr Thr 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  98

Asp Ile Leu Pro Gly Thr Gly Phe Thr Thr 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  99

Asp Ile Leu Pro Gly Thr Gly Tyr Thr Val 
1               5                   10  


<210>  100
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  100

Asp Ile Ile Pro Gly Ser Gly Trp Thr Asn 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  101

Asp Ile Leu Pro Gly Ser Gly Tyr Thr Asn 
1               5                   10  


<210>  102
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  102

Asp Ile Leu Pro Gly Ser Gly Trp Thr Asn 
1               5                   10  


<210>  103
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  103

Asp Ile Leu Pro Gly Ser Gly His Thr Thr 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  104

Asp Ile Leu Pro Gly Thr Gly Tyr Thr Asn 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  105

Asp Ile Leu Pro Ala Ser Ser Ser Thr Asn 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  106

Asp Ile Leu Pro Gly Ser Gly His Thr Ile 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks


<220>
<221>  MUTAGEN
<222>  (3)..(3)
<223>  Xaa is selected from  I and L

<220>
<221>  MUTAGEN
<222>  (6)..(6)
<223>  Xaa is selected from S and T

<220>
<221>  MUTAGEN
<222>  (8)..(8)
<223>  Xaa is selected from A, F, H, and W

<220>
<221>  MUTAGEN
<222>  (10)..(10)
<223>  Xaa is selected from D, H, I, L, and N

<400>  107

Asp Ile Xaa Pro Gly Xaa Gly Xaa Thr Xaa 
1               5                   10  


<210>  108
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  108

Lys Ser Ser Gln Ser Leu Leu Trp Phe Val Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  109
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  109

Lys Ser Ser Gln Ser Leu Leu Tyr Val Tyr Gly Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  110
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  110

Lys Ser Ser Gln Ser Leu Leu Phe Arg Pro Thr Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  111
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  111

Lys Ser Ser Gln Ser Leu Leu Tyr Thr Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  112
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  112

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Gly Asn Gln Arg Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  113
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  113

Lys Ser Ser Gln Ser Leu Leu Pro Ser Trp Asn Gln Ser Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  114
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  114

Lys Ser Ser Gln Ser Leu Leu Phe Ser Ala Asn Gln Arg Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  115
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  115

Lys Ser Ser Gln Ser Leu Leu Thr Ser Tyr Asn Gln Arg Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  116
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks


<220>
<221>  MUTAGEN
<222>  (8)..(8)
<223>  Xaa is selected from F, P, S, T, W, and Y

<220>
<221>  MUTAGEN
<222>  (9)..(9)
<223>  Xaa is selected from F, S, T, R, and V

<220>
<221>  MUTAGEN
<222>  (10)..(10)
<223>  Xaa is selected from A, G, P, S, W, Y, and V

<220>
<221>  MUTAGEN
<222>  (11)..(11)
<223>  Xaa is selected from G, N, and T

<220>
<221>  MUTAGEN
<222>  (13)..(13)
<223>  Xaa is selected from K, R, and S

<400>  116

Lys Ser Ser Gln Ser Leu Leu Xaa Xaa Xaa Xaa Gln Xaa Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  117
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  117

His Ala Ser Thr Arg Glu Ser 
1               5           


<210>  118
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  118

Trp Ala Ser Thr Arg Ser Ser 
1               5           


<210>  119
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  119

Trp Ala Ser Thr Arg Asp Ser 
1               5           


<210>  120
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks


<220>
<221>  MUTAGEN
<222>  (1)..(1)
<223>  Xaa is selected from H and W

<220>
<221>  MUTAGEN
<222>  (6)..(6)
<223>  Xaa is selected from D, E, and S

<400>  120

Xaa Ala Ser Thr Arg Xaa Ser 
1               5           


<210>  121
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  121

Gln Asn Asp Phe Ser Trp Pro Leu Thr 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  122

Gln Asn Asp Asp Ser Tyr Pro Leu Thr 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  123

Gln Asn Asp Asp Tyr Trp Pro Leu Thr 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  124

Gln Asn Asp Asp Thr Tyr Pro Met Thr 
1               5                   


<210>  125
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  125

Gln Asn Asp Phe Thr Tyr Pro Leu Thr 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  126

Gln Asn Asp Asp Thr Tyr Pro Leu Thr 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  127

Gln Asn Asp Leu Thr Tyr Pro Leu Thr 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks


<220>
<221>  MUTAGEN
<222>  (4)..(4)
<223>  Xaa is selected from D, F, and L

<220>
<221>  MUTAGEN
<222>  (5)..(5)
<223>  Xaa is selected from S, T, and Y

<220>
<221>  MUTAGEN
<222>  (6)..(6)
<223>  Xaa is selected from W and Y

<220>
<221>  MUTAGEN
<222>  (8)..(8)
<223>  Xaa is selected from L and M

<400>  128

Gln Asn Asp Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  129
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  129

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Gly Ser Gly Trp Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  130
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  130

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Val Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Val Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  131
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  131

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Pro Phe 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Gly Thr Gly Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  132
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  132

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Pro Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Gly Thr Gly Trp Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  133
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  133

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ile Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Phe Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  134
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  134

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Pro Phe 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  135
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  135

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Pro His 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  136
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  136

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Leu Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Gly Thr Gly Phe Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  137
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  137

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Arg Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Gly Thr Gly Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  138
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  138

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Pro His 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Tyr Thr Ile Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  139
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  139

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ala Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Phe Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  140
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  140

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Pro Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Val Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  141
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  141

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Tyr Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Phe Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  142
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  142

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly His Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  143
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  143

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Ala Thr His Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  144
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  144

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Val Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  145
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  145

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Leu Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  146
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  146

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Val Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  147
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  147

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Asp Ala His 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Phe Thr Asp Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  148
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  148

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ala Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Trp Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  149
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  149

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly His Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  150
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  150

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ile Pro His 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Trp Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  151
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  151

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Phe Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Ala Ser Ser Ser Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  152
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  152

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly His Thr Ile Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  153
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  153

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ala Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Gly Thr Gly Tyr Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  154
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  154

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Gly Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Tyr Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  155
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  155

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Asn Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  156
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  156

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Ser His 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Ser Gly Phe Thr His Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Lys Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr 
            100                 105                 


<210>  157
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  157

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Trp Phe 
            20                  25                  30          


Val Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr His Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Asp Ser Tyr Pro Leu Thr 
            100             


<210>  158
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  158

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Gly Asn Gln Arg Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Ser Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Asp Thr Tyr Pro Met Thr 
            100             


<210>  159
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  159

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Pro Ser 
            20                  25                  30          


Trp Asn Gln Ser Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Phe Thr Tyr Pro Leu Thr 
            100             


<210>  160
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  160

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser 
            20                  25                  30          


Ala Asn Gln Arg Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Asp Thr Tyr Pro Leu Thr 
            100             


<210>  161
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  161

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Thr Ser 
            20                  25                  30          


Tyr Asn Gln Arg Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Leu Thr Tyr Pro Leu Thr 
            100             


<210>  162
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  162

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Val 
            20                  25                  30          


Tyr Gly Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Phe Ser Trp Pro Leu Thr 
            100             


<210>  163
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  163

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Arg 
            20                  25                  30          


Pro Thr Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Asp Ser Tyr Pro Leu Thr 
            100             


<210>  164
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  164

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Asp Tyr Trp Pro Leu Thr 
            100             


<210>  165
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  165

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  166
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  166

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ala Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Phe Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  167
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CDR or mutagens thereof in Human IgG variable domain 
       frameworks

<400>  167

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ala Pro Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Thr Gly Phe Thr Thr Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asn Ser Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


