                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       Benhar, Itai
       Vaks, Lilach
 
<120>  BISPECIFIC AND MONOSPECIFIC, ASYMMETRIC ANTIBODIES AND METHODS OF
GENERATING SAME

<130>  52585

<150>  US 61/453,591
<151>  2011-03-17

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
gaagcctttg accaggcacc acaggctgac ctggttcttg gtcatctcct cccggcatgg       60

gggcagggtg tacac                                                        75


<210>  2
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ggatgggggc agggtgcaca cctgtggttc tcgg                                   34


<210>  3
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
ggatagaagc ctttgaccgc gcagctcagg ctgacctggt tcttg                       45


<210>  4
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
gtccacggtg agcttgctaa cgaggaagaa ggagccgtc                              39


<210>  5
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
atatacatat ggacattgtg ctg                                               23


<210>  6
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
tatatacgta cgtttgattt ccagtttggt gccgcaaccg aacgtccgag g                51


<210>  7
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
tatatagaat tcttactctc ccctgttgaa gctctttgtg                             40


<210>  8
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
aaacagaggc ctggacagtg tctggaatgg attg                                   34


<210>  9
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
tatatagcta gcggaggaga ctgtgag                                           27


<210>  10
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
gcccaaatct gccgacaaaa ctcacacatg cccacc                                 36


<210>  11
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  11
tgtgtgagtt ttgtcggcag atttgggctc aactctcttg                             40


<210>  12
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  12
gaggagatga ccaagaacca ggt                                               23


<210>  13
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  13
atatacatat gcaggtcaaa ctgc                                              24


<210>  14
<211>  660
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Light chain T427 (wt IgG) coding sequence

<400>  14
atggacattg tgctgaccca atctccaact tctttggctg tgtctctagg gcagagggcc       60

accatatcct gcagagccag tgaaagtgtt gatagttatg gcaatagttt tatgcactgg      120

ttccagcaga aaccaggaca gccacccaaa ctcctcatct atcgtgcatc caacctagaa      180

tctgggatcc ctgccaggtt cagtggcagt gggtcttgga cagacttcac cctcaccatt      240

aatcctgtgg aggctgatga tgttgcaacc tattactgtc agcaaagtaa tgaggatcct      300

cggacgttcg gtggaggcac caaactggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttaa      660


<210>  15
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain T427 (wt IgG)

<400>  15

Met Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser 
            20                  25                  30          


Tyr Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Trp Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Asn Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  16
<211>  648
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Light chain FRP5 (wt IgG) coding sequence

<400>  16
atggacatcc agctgaccca gtctcacaaa ttcctgtcca cttcagtagg agacagggtc       60

agcatcacct gcaaggccag tcaggatgtg tataatgctg ttgcctggta tcaacagaaa      120

ccaggacaat ctcctaaact tctgatttac tcggcatcct cccggtacac tggagtccct      180

tctcgcttca ctggcagtgg ctctgggccg gatttcactt tcaccatcag cagtgtgcag      240

gctgaagacc tggcagttta tttctgtcag caacattttc gtactccatt cacgttcggc      300

tcggggacaa aattggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaa                   648


<210>  17
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain FRP5 (wt IgG)

<400>  17

Met Asp Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Thr Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr Ile Ser Ser Val Gln 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Phe Arg Thr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  18
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Light chain anti-Tac (wt IgG) coding sequence

<400>  18
atgcaaattg ttctcaccca gtctccagca atcatgtctg catctccagg ggagaaggtc       60

accataacct gcagtgccag ctcaagtata agttacatgc actggttcca gcagaagcca      120

ggcacttctc ccaaactctg gatttatacc acatccaacc tggcttctgg agtccctgct      180

cgcttcagtg gcagtggatc tgggacctct tactctctca caatcagccg aatggaggct      240

gaagatgctg ccacttatta ctgccatcaa aggagtactt acccactcac gttcggttct      300

gggaccaagc tggaaataaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttaa                      645


<210>  19
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain anti-Tac (wt IgG)

<400>  19

Met Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
1               5                   10                  15      


Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr 
            20                  25                  30          


Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile 
        35                  40                  45              


Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  20
<211>  657
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Light chain T427 A104C:Cys218del (Cys) coding sequence

<400>  20
atggacattg tgctgaccca atctccaact tctttggctg tgtctctagg gcagagggcc       60

accatatcct gcagagccag tgaaagtgtt gatagttatg gcaatagttt tatgcactgg      120

ttccagcaga aaccaggaca gccacccaaa ctcctcatct atcgtgcatc caacctagaa      180

tctgggatcc ctgccaggtt cagtggcagt gggtcttgga cagacttcac cctcaccatt      240

aatcctgtgg aggctgatga tgttgcaacc tattactgtc agcaaagtaa tgaggatcct      300

cggacgttcg gttgtggcac caaactggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtaa         657


<210>  21
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain T427 A104C:Cys218del (Cys)

<400>  21

Met Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser 
            20                  25                  30          


Tyr Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Trp Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Asn Glu Asp Pro Arg Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    210                 215             


<210>  22
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 (wt IgG human gamma 1) coding sequence

<400>  22
atgcaggtcc aactgcagca gccggggact gaactggtga ggcctggagc ttcagtgaag       60

ctgtcctgca aggcttctgg cttctccttc accagttact ggatgaactg ggtgaagcag      120

aggcctggac aaggccttga gtggattggc atgattcatc cttccgatag tgaaactagg      180

ttaaatcaga agttcaagga cagggccaca ttgactgtag acaaatcctc cagcacagcc      240

tacatgcaac tcagcagccc gacatctgag gactctgcgg tctattactg tgcaagtgag      300

atggattatt actttgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa tga                                  1353


<210>  23
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 (wt IgG human gamma 1)

<400>  23

Met Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Ser 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Glu Met Asp Tyr Tyr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  24
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain FRP5 (wt IgG human gamma 1) coding sequence

<400>  24
atgcaggtac aactgcagca gtctggacct gaactgaaga agcctggaga gacagtcaag       60

atctcctgca aggcctctgg gtatcctttc acaaactatg gaatgaactg ggtgaagcag      120

gctccaggac agggtttaaa gtggatgggc tggattaaca cctccactgg agagtcaaca      180

tttgctgatg acttcaaggg acggtttgac ttctctttgg aaacctctgc caacactgcc      240

tatttgcaga tcaacaacct caaaagtgaa gacatggcta catatttctg tgcaagatgg      300

gaggtttacc acggctacgt tccttactgg ggccaaggga ccacggtcac cgtttcctct      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa tga                                  1353


<210>  25
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain FRP5 (wt IgG human gamma 1)

<400>  25

Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
1               5                   10                  15      


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn 
            20                  25                  30          


Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp 
        35                  40                  45              


Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp 
    50                  55                  60                  


Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  26
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain anti-Tac (wt IgG human gamma 1) coding sequence

<400>  26
atgcaggtca aactgcagga gtctggggct gaactggcaa aacctggggc ctcagtgaag       60

atgtcctgca aggcttctgg ctacaccttt actagctaca ggatgcactg ggtaaaacag      120

aggcctggac agggtctgga atggattgga tatattaatc ctagcactgg gtatactgaa      180

tacaatcaga agttcaagga caaggccaca ttgactgcag acaaatcctc cagcacagcc      240

tacatgcaac tgagcagcct gacatttgag gactctgcag tctattactg tgcaagaggg      300

gggggggtct ttgactactg gggccaagga accactctca cagtctcctc cgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ccccgggtaa atga                                            1344


<210>  27
<211>  447
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain anti-Tac (wt IgG human gamma 1)

<400>  27

Met Gln Val Lys Leu Gln Glu Ser Gly Ala Glu Leu Ala Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Arg Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  28
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 T366W:S354C (knob) coding sequence

<400>  28
atgcaggtcc aactgcagca gccggggact gaactggtga ggcctggagc ttcagtgaag       60

ctgtcctgca aggcttctgg cttctccttc accagttact ggatgaactg ggtgaagcag      120

aggcctggac aaggccttga gtggattggc atgattcatc cttccgatag tgaaactagg      180

ttaaatcaga agttcaagga cagggccaca ttgactgtag acaaatcctc cagcacagcc      240

tacatgcaac tcagcagccc gacatctgag gactctgcgg tctattactg tgcaagtgag      300

atggattatt actttgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg ccgggaggag     1080

atgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa tga                                  1353


<210>  29
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 T366W:S354C (knob) coding sequence

<400>  29

Met Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Ser 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Glu Met Asp Tyr Tyr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Glu Pro 
                245                 250                 255     


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  30
<211>  1352
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 T366S:L368A:Y407V:Y349C (hole) coding sequence

<400>  30
atgcaggtcc aactgcagca gccggggact gaactggtga ggcctggagc ttcagtgaag       60

ctgtcctgca aggcttctgg cttctccttc accagttact ggatgaactg ggtgaagcag      120

aggcctggac aaggccttga gtggattggc atgattcatc cttccgatag tgaaactagg      180

ttaaatcaga agttcaagga cagggccaca ttgactgtag acaaatcctc cagcacagcc      240

tacatgcaac tcagcagccc gacatctgag gactctgcgg tctattactg tgcaagtgag      300

atggattatt actttgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact gaacaaggac      720

cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg      780

aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt      840

acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag cagtacaaca      900

gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg aatggcaagg      960

agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca     1020

aagccaaagg gcagccccga gaaccacagg tgtgcaccct gcccccatcc cgggaggaga     1080

tgaccaagaa ccaggtcagc ctgagctgcg cggtcaaagg cttctatccc agcgacatcg     1140

ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc     1200

tggactccga cggctccttc ttcctcgtta gcaagctcac cgtggacaag agcaggtggc     1260

agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc     1320

agaagagcct ctccctgtcc ccgggtaaat ga                                   1352


<210>  31
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 T366S:L368A:Y407V:Y349C (hole)

<400>  31

Met Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Ser 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Glu Met Asp Tyr Tyr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  32
<211>  2406
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain T427-PE38 coding sequence

<400>  32
atgcaggtcc aactgcagca gccggggact gaactggtga ggcctggagc ttcagtgaag       60

ctgtcctgca aggcttctgg cttctccttc accagttact ggatgaactg ggtgaagcag      120

aggcctggac aaggccttga gtggattggc atgattcatc cttccgatag tgaaactagg      180

ttaaatcaga agttcaagga cagggccaca ttgactgtag acaaatcctc cagcacagcc      240

tacatgcaac tcagcagccc gacatctgag gactctgcgg tctattactg tgcaagtgag      300

atggattatt actttgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa gcttccggag gtcccgaggg cggcagcctg     1380

gccgcgctga ccgcgcacca ggcttgccac ctgccgctgg agactttcac ccgtcatcgc     1440

cagccgcgcg gctgggaaca actggagcag tgcggctatc cggtgcagcg gctggtcgcc     1500

ctctacctgg cggcgcggct gtcgtggaac caggtcgacc aggtgatccg caacgccctg     1560

gccagccccg gcagcggcgg cgacctgggc gaagcgatcc gcgagcagcc ggagcaggcc     1620

cgtctggccc tgaccctggc cgccgccgag agcgagcgct tcgtccggca gggcaccggc     1680

aacgacgagg ccggcgcggc caacggcccg gcggacagcg gcgacgccct gctggagcgc     1740

aactatccca ctggcgcgga gttcctcggc gacggcggcg acgtcagctt cagcacccgc     1800

ggcacgcaga actggacggt ggagcggctg ctccaggcgc accgccaact ggaggagcgc     1860

ggctatgtgt tcgtcggcta ccacggcacc ttcctcgaag cggcgcaaag catcgtcttc     1920

ggcggggtgc gcgcgcgcag ccaggacctc gacgcgatct ggcgcggttt ctatatcgcc     1980

ggcgatccgg cgctggccta cggctacgcc caggaccagg aacccgacgc acgcggccgg     2040

atccgcaacg gtgccctgct gcgggtctat gtgccgcgct cgagcctgcc gggcttctac     2100

cgcaccagcc tgaccctggc cgcgccggag gcggcgggcg aggtcgaacg gctgatcggc     2160

catccgctgc cgctgcgcct ggacgccatc accggccccg aggaggaagg cgggcgcctg     2220

gagaccattc tcggctggcc gctggccgag cgcaccgtgg tgattccctc ggcgatcccc     2280

accgacccgc gcaacgtcgg cggcgacctc gacccgtcca gcatccccga caaggaacag     2340

gcgatcagcg ccctgccgga ctacgccagc cagcccggca aaccgccgcg cgaggacctg     2400

aagtaa                                                                2406


<210>  33
<211>  800
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain T427-PE38

<400>  33

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Glu Met Asp Tyr Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala 
    450                 455                 460                 


His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln 
465                 470                 475                 480 


Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg 
                485                 490                 495     


Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp 
            500                 505                 510         


Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu 
        515                 520                 525             


Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr 
    530                 535                 540                 


Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn 
545                 550                 555                 560 


Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu 
                565                 570                 575     


Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly 
            580                 585                 590         


Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg 
        595                 600                 605             


Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val 
    610                 615                 620                 


Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly 
625                 630                 635                 640 


Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe 
                645                 650                 655     


Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln 
            660                 665                 670         


Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val 
        675                 680                 685             


Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr 
    690                 695                 700                 


Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His 
705                 710                 715                 720 


Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly 
                725                 730                 735     


Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val 
            740                 745                 750         


Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp 
        755                 760                 765             


Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu 
    770                 775                 780                 


Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
785                 790                 795                 800 


<210>  34
<211>  2406
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain T427-PE38 T366S:L368A:Y407V:Y349C (hole) coding 
       sequence

<400>  34
atgcaggtcc aactgcagca gccggggact gaactggtga ggcctggagc ttcagtgaag       60

ctgtcctgca aggcttctgg cttctccttc accagttact ggatgaactg ggtgaagcag      120

aggcctggac aaggccttga gtggattggc atgattcatc cttccgatag tgaaactagg      180

ttaaatcaga agttcaagga cagggccaca ttgactgtag acaaatcctc cagcacagcc      240

tacatgcaac tcagcagccc gacatctgag gactctgcgg tctattactg tgcaagtgag      300

atggattatt actttgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtgcaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgagctgc gcggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtt agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa gcttccggag gtcccgaggg cggcagcctg     1380

gccgcgctga ccgcgcacca ggcttgccac ctgccgctgg agactttcac ccgtcatcgc     1440

cagccgcgcg gctgggaaca actggagcag tgcggctatc cggtgcagcg gctggtcgcc     1500

ctctacctgg cggcgcggct gtcgtggaac caggtcgacc aggtgatccg caacgccctg     1560

gccagccccg gcagcggcgg cgacctgggc gaagcgatcc gcgagcagcc ggagcaggcc     1620

cgtctggccc tgaccctggc cgccgccgag agcgagcgct tcgtccggca gggcaccggc     1680

aacgacgagg ccggcgcggc caacggcccg gcggacagcg gcgacgccct gctggagcgc     1740

aactatccca ctggcgcgga gttcctcggc gacggcggcg acgtcagctt cagcacccgc     1800

ggcacgcaga actggacggt ggagcggctg ctccaggcgc accgccaact ggaggagcgc     1860

ggctatgtgt tcgtcggcta ccacggcacc ttcctcgaag cggcgcaaag catcgtcttc     1920

ggcggggtgc gcgcgcgcag ccaggacctc gacgcgatct ggcgcggttt ctatatcgcc     1980

ggcgatccgg cgctggccta cggctacgcc caggaccagg aacccgacgc acgcggccgg     2040

atccgcaacg gtgccctgct gcgggtctat gtgccgcgct cgagcctgcc gggcttctac     2100

cgcaccagcc tgaccctggc cgcgccggag gcggcgggcg aggtcgaacg gctgatcggc     2160

catccgctgc cgctgcgcct ggacgccatc accggccccg aggaggaagg cgggcgcctg     2220

gagaccattc tcggctggcc gctggccgag cgcaccgtgg tgattccctc ggcgatcccc     2280

accgacccgc gcaacgtcgg cggcgacctc gacccgtcca gcatccccga caaggaacag     2340

gcgatcagcg ccctgccgga ctacgccagc cagcccggca aaccgccgcg cgaggacctg     2400

aagtaa                                                                2406


<210>  35
<211>  800
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain T427-PE38 T366S:L368A:Y407V:Y349C (hole)

<400>  35

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Glu Met Asp Tyr Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala 
    450                 455                 460                 


His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln 
465                 470                 475                 480 


Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg 
                485                 490                 495     


Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp 
            500                 505                 510         


Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu 
        515                 520                 525             


Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr 
    530                 535                 540                 


Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn 
545                 550                 555                 560 


Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu 
                565                 570                 575     


Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly 
            580                 585                 590         


Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg 
        595                 600                 605             


Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val 
    610                 615                 620                 


Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly 
625                 630                 635                 640 


Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe 
                645                 650                 655     


Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln 
            660                 665                 670         


Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val 
        675                 680                 685             


Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr 
    690                 695                 700                 


Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His 
705                 710                 715                 720 


Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly 
                725                 730                 735     


Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val 
            740                 745                 750         


Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp 
        755                 760                 765             


Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu 
    770                 775                 780                 


Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
785                 790                 795                 800 


<210>  36
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain FRP5 T366W:S354C (knob) coding sequence

<400>  36
atgcaggtac aactgcagca gtctggacct gaactgaaga agcctggaga gacagtcaag       60

atctcctgca aggcctctgg gtatcctttc acaaactatg gaatgaactg ggtgaagcag      120

gctccaggac agggtttaaa gtggatgggc tggattaaca cctccactgg agagtcaaca      180

tttgctgatg acttcaaggg acggtttgac ttctctttgg aaacctctgc caacactgcc      240

tatttgcaga tcaacaacct caaaagtgaa gacatggcta catatttctg tgcaagatgg      300

gaggtttacc acggctacgt tccttactgg ggccaaggga ccacggtcac cgtttcctct      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg ccgggaggag     1080

atgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa tga                                  1353


<210>  37
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain FRP5 T366W:S354C (knob)

<400>  37

Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
1               5                   10                  15      


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn 
            20                  25                  30          


Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp 
        35                  40                  45              


Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp 
    50                  55                  60                  


Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  38
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain FRP5 T366S:L368A:Y407V:Y349C (hole) coding sequence

<400>  38
atgcaggtac aactgcagca gtctggacct gaactgaaga agcctggaga gacagtcaag       60

atctcctgca aggcctctgg gtatcctttc acaaactatg gaatgaactg ggtgaagcag      120

gctccaggac agggtttaaa gtggatgggc tggattaaca cctccactgg agagtcaaca      180

tttgctgatg acttcaaggg acggtttgac ttctctttgg aaacctctgc caacactgcc      240

tatttgcaga tcaacaacct caaaagtgaa gacatggcta catatttctg tgcaagatgg      300

gaggtttacc acggctacgt tccttactgg ggccaaggga ccacggtcac cgtttcctct      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtgcaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgagctgc gcggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtt agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa tga                                  1353


<210>  39
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain FRP5 T366S:L368A:Y407V:Y349C (hole)

<400>  39

Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
1               5                   10                  15      


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn 
            20                  25                  30          


Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp 
        35                  40                  45              


Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp 
    50                  55                  60                  


Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  40
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 T366W:S354C (knob) and A44C:C222A (Cys) coding 
       sequence

<400>  40
atgcaggtcc aactgcagca gccggggact gaactggtga ggcctggagc ttcagtgaag       60

ctgtcctgca aggcttctgg cttctccttc accagttact ggatgaactg ggtgaagcag      120

aggcctggac aatgccttga gtggattggc atgattcatc cttccgatag tgaaactagg      180

ttaaatcaga agttcaagga cagggccaca ttgactgtag acaaatcctc cagcacagcc      240

tacatgcaac tcagcagccc gacatctgag gactctgcgg tctattactg tgcaagtgag      300

atggattatt actttgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatctgccg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg ccgggaggag     1080

atgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc cccgggtaaa tga                                  1353


<210>  41
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain T427 T366W:S354C (knob) and A44C:C222A (Cys)

<400>  41

Met Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Ser 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Glu Met Asp Tyr Tyr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Ala Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  42
<211>  216
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  42

Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
1               5                   10                  15      


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 
            20                  25                  30          


Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
        35                  40                  45              


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 
    50                  55                  60                  


Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
65                  70                  75                  80  


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile 
                85                  90                  95      


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 
            100                 105                 110         


Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
        115                 120                 125             


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 
    130                 135                 140                 


Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly 
145                 150                 155                 160 


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
                165                 170                 175     


Asp Pro Arg Asn Val Gly Gly Asp Leu Ala Pro Ser Ser Ile Pro Asp 
            180                 185                 190         


Gln Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
        195                 200                 205             


Lys Pro Ser Arg Glu Asp Leu Lys 
    210                 215     


<210>  43
<211>  536
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  43

Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn 
385                 390                 395                 400 


Thr Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly 
                405                 410                 415     


His Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly 
            420                 425                 430         


Val Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys 
        435                 440                 445             


Thr His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala 
    450                 455                 460                 


Ile Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val 
465                 470                 475                 480 


Gly Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser 
                485                 490                 495     


Ser Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val 
            500                 505                 510         


Leu Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu 
        515                 520                 525             


Ser Leu Phe Phe Glu Ile Lys Ser 
    530                 535     


<210>  44
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  interleukin 2

<400>  44

Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
1               5                   10                  15      


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
            20                  25                  30          


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
        35                  40                  45              


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
    50                  55                  60                  


Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile 
65                  70                  75                  80  


Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu 
            100                 105                 110         


Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
        115                 120                 125         


<210>  45
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  46
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr Ser Ser Cys Leu Val 
1               5                   10                  15      


Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu Val Thr Cys Pro Leu 
            20                  25                  30          


Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu 
        35                  40                  45              


Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val 
    50                  55                  60                  


Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr 
65                  70                  75                  80  


Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp 
                85                  90                  95      


Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile 
            100                 105                 110         


Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn 
        115                 120                 125             


Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp 
    130                 135                 140                 


Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile 
145                 150                 155                 160 


His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr 
                165                 170                 175     


Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp 
            180                 185                 190         


Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys 
        195                 200                 205             


Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile 
    210                 215                 220                 


Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 
225                 230                 235                 240 


Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala 
                245                 250                 255     


Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser 
            260                 265                 270         


Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln 
        275                 280                 285             


Asp Lys 
    290 


<210>  47
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  48
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  49
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  49

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  50
<211>  576
<212>  PRT
<213>  Ricinus communis

<400>  50

Met Lys Pro Gly Gly Asn Thr Ile Val Ile Trp Met Tyr Ala Val Ala 
1               5                   10                  15      


Thr Trp Leu Cys Phe Gly Ser Thr Ser Gly Trp Ser Phe Thr Leu Glu 
            20                  25                  30          


Asp Asn Asn Ile Phe Pro Lys Gln Tyr Pro Ile Ile Asn Phe Thr Thr 
        35                  40                  45              


Ala Gly Ala Thr Val Gln Ser Tyr Thr Asn Phe Ile Arg Ala Val Arg 
    50                  55                  60                  


Gly Arg Leu Thr Thr Gly Ala Asp Val Arg His Glu Ile Pro Val Leu 
65                  70                  75                  80  


Pro Asn Arg Val Gly Leu Pro Ile Asn Gln Arg Phe Ile Leu Val Glu 
                85                  90                  95      


Leu Ser Asn His Ala Glu Leu Ser Val Thr Leu Ala Leu Asp Val Thr 
            100                 105                 110         


Asn Ala Tyr Val Val Gly Tyr Arg Ala Gly Asn Ser Ala Tyr Phe Phe 
        115                 120                 125             


His Pro Asp Asn Gln Glu Asp Ala Glu Ala Ile Thr His Leu Phe Thr 
    130                 135                 140                 


Asp Val Gln Asn Arg Tyr Thr Phe Ala Phe Gly Gly Asn Tyr Asp Arg 
145                 150                 155                 160 


Leu Glu Gln Leu Ala Gly Asn Leu Arg Glu Asn Ile Glu Leu Gly Asn 
                165                 170                 175     


Gly Pro Leu Glu Glu Ala Ile Ser Ala Leu Tyr Tyr Tyr Ser Thr Gly 
            180                 185                 190         


Gly Thr Gln Leu Pro Thr Leu Ala Arg Ser Phe Ile Ile Cys Ile Gln 
        195                 200                 205             


Met Ile Ser Glu Ala Ala Arg Phe Gln Tyr Ile Glu Gly Glu Met Arg 
    210                 215                 220                 


Thr Arg Ile Arg Tyr Asn Arg Arg Ser Ala Pro Asp Pro Ser Val Ile 
225                 230                 235                 240 


Thr Leu Glu Asn Ser Trp Gly Arg Leu Ser Thr Ala Ile Gln Glu Ser 
                245                 250                 255     


Asn Gln Gly Ala Phe Ala Ser Pro Ile Gln Leu Gln Arg Arg Asn Gly 
            260                 265                 270         


Ser Lys Phe Ser Val Tyr Asp Val Ser Ile Leu Ile Pro Ile Ile Ala 
        275                 280                 285             


Leu Met Val Tyr Arg Cys Ala Pro Pro Pro Ser Ser Gln Phe Ser Leu 
    290                 295                 300                 


Leu Ile Arg Pro Val Val Pro Asn Phe Asn Ala Asp Val Cys Met Asp 
305                 310                 315                 320 


Pro Glu Pro Ile Val Arg Ile Val Gly Arg Asn Gly Leu Cys Val Asp 
                325                 330                 335     


Val Arg Asp Gly Arg Phe His Asn Gly Asn Ala Ile Gln Leu Trp Pro 
            340                 345                 350         


Cys Lys Ser Asn Thr Asp Ala Asn Gln Leu Trp Thr Leu Lys Arg Asp 
        355                 360                 365             


Asn Thr Ile Arg Ser Asn Gly Lys Cys Leu Thr Thr Tyr Gly Tyr Ser 
    370                 375                 380                 


Pro Gly Val Tyr Val Met Ile Tyr Asp Cys Asn Thr Ala Ala Thr Asp 
385                 390                 395                 400 


Ala Thr Arg Trp Gln Ile Trp Asp Asn Gly Thr Ile Ile Asn Pro Arg 
                405                 410                 415     


Ser Ser Leu Val Leu Ala Ala Thr Ser Gly Asn Ser Gly Thr Thr Leu 
            420                 425                 430         


Thr Val Gln Thr Asn Ile Tyr Ala Val Ser Gln Gly Trp Leu Pro Thr 
        435                 440                 445             


Asn Asn Thr Gln Pro Phe Val Thr Thr Ile Val Gly Leu Tyr Gly Leu 
    450                 455                 460                 


Cys Leu Gln Ala Asn Ser Gly Gln Val Trp Ile Glu Asp Cys Ser Ser 
465                 470                 475                 480 


Glu Lys Ala Glu Gln Gln Trp Ala Leu Tyr Ala Asp Gly Ser Ile Arg 
                485                 490                 495     


Pro Gln Gln Asn Arg Asp Asn Cys Leu Thr Ser Asp Ser Asn Ile Arg 
            500                 505                 510         


Glu Thr Val Val Lys Ile Leu Ser Cys Gly Pro Ala Ser Ser Gly Gln 
        515                 520                 525             


Arg Trp Met Phe Lys Asn Asp Gly Thr Ile Leu Asn Leu Tyr Ser Gly 
    530                 535                 540                 


Leu Val Leu Asp Val Arg Ala Ser Asp Pro Ser Leu Lys Gln Ile Ile 
545                 550                 555                 560 


Leu Tyr Pro Leu His Gly Asp Pro Asn Gln Ile Trp Leu Pro Leu Phe 
                565                 570                 575     


<210>  51
<211>  651
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  51
gcggagttcc tcggcgacgg cggcgacgtc agcttcagca cccgcggcac gcagaactgg       60

acggtggagc ggctgctcca ggcgcaccgc caactggagg agcgcggcta tgtgttcgtc      120

ggctaccacg gcaccttcct cgaagcggcg caaagcatcg tcttcggcgg ggtgcgcgcg      180

cgcagccagg accttgacgc gatctggcgc ggtttctata tcgccggcga tccggcgctg      240

gcctacggct acgcccagga ccaggaaccc gacgcgcgcg gccggatccg caacggtgcc      300

ctgctgcggg tctatgtgcc gcgctcgagt ctgccgggct tctaccgcac cggcctgacc      360

ctggccgcgc cggaggcggc gggcgaggtc gaacggctga tcggccatcc gctgccgctg      420

cgcctggacg ccatcaccgg ccccgaggag gaaggcgggc gcctggagac cattctcggc      480

tggccgctgg ccgagcgcac cgtggtgatt ccctcggcga tccccaccga cccacgcaac      540

gtcggcggcg acctcgcccc gtccagcatc cccgaccagg aacaggcgat cagcgccctg      600

ccggactacg ccagccagcc cggcaaaccg tcgcgcgagg acctgaagta a               651


<210>  52
<211>  1611
<212>  DNA
<213>  Corynebacterium diphtheriae

<400>  52
atgggcgctg atgatgttgt tgattcttct aaatcttttg tgatggaaaa cttttcttcg       60

taccacggga ctaaacctgg ttatgtagat tccattcaaa aaggtataca aaagccaaaa      120

tctggtacac aaggaaatta tgacgatgat tggaaagggt tttatagtac cgacaataaa      180

tacgacgctg cgggatactc tgtagataat gaaaacccgc tctctggaaa agctggaggc      240

gtggtcaaag tgacgtatcc aggactgacg aaggttctcg cactaaaagt ggataatgcc      300

gaaactatta agaaagagtt aggtttaagt ctcactgaac cgttgatgga gcaagtcgga      360

acggaagagt ttatcaaaag gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc      420

ttcgctgagg ggagttctag cgttgaatat attaataact gggaacaggc gaaagcgtta      480

agcgtagaac ttgagattaa ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat      540

gagtatatgg ctcaagcctg tgcaggaaat cgtgtcaggc gatcagtagg tagctcattg      600

tcatgcataa atcttgattg ggatgtcata agggataaaa ctaagacaaa gatagagtct      660

ttgaaagagc atggccctat caaaaataaa atgagcgaaa gtcccaataa aacagtatct      720

gaggaaaaag ctaaacaata cctagaagaa tttcatcaaa cggcattaga gcatcctgaa      780

ttgtcagaac ttaaaaccgt tactgggacc aatcctgtat tcgctggggc taactatgcg      840

gcgtgggcag taaacgttgc gcaagttatc gatagcgaaa cagctgataa tttggaaaag      900

acaactgctg ctctttcgat acttcctggt atcggtagcg taatgggcat tgcagacggt      960

gccgttcacc acaatacaga agagatagtg gcacaatcaa tagctttatc atctttaatg     1020

gttgctcaag ctattccatt ggtaggagag ctagttgata ttggtttcgc tgcatataat     1080

tttgtagaga gtattatcaa tttatttcaa gtagttcata attcgtataa tcgtcccgcg     1140

tattctccgg ggcataaaac gcaaccattt cttcatgacg ggtatgctgt cagttggaac     1200

actgttgaag attcgataat ccgaactggt tttcaagggg agagtgggca cgacataaaa     1260

attactgctg aaaatacccc gcttccaatc gcgggtgtcc tactaccgac tattcctgga     1320

aagctggacg ttaataagtc caagactcat atttccgtaa atggtcggaa aataaggatg     1380

cgttgcagag ctatagacgg tgatgtaact ttttgtcgcc ctaaatctcc tgtttatgtt     1440

ggtaatggtg tgcatgcgaa tcttcacgtg gcatttcaca gaagcagctc ggagaaaatt     1500

cattctaatg aaatttcatc ggattccata ggcgttcttg ggtaccagaa aacagtagat     1560

cacaccaagg ttaattctaa gctatcgcta ttttttgaaa tcaaaagctg a              1611


<210>  53
<211>  698
<212>  DNA
<213>  Artificial sequence

<220>
<223>  interleukin 2


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  53
gggnggggga caaagaaaac acagctacaa ctggagcatt tacttctgga tttacagatg       60

attttgaatg gaattaataa ttacaagaat cccaaactca ccaggatgct cacatttaag      120

ttttacatgc ccaagaaggc cacagaactg aaacatcttc agtgtctaga agaagaactc      180

aaacctctgg aggaagtgct aaatttagct caaagcaaaa actttcactt aagacccagg      240

gacttaatca gcaatatcaa cgtaatagtt ctggaactaa agggatctga aacaacattc      300

atgtgtgaat atgctgatga gacagcaacc attgtagaat ttctgaacag atggattacc      360

ttttgtcaaa gcatcatctc aacactgact tgataattaa gtgcttccca cttaaaacat      420

atcaggcctt ctatttattt aaatatttaa attttatatt tattgttgaa tgtatggttt      480

gctacctatt gtaactatta ttcttaatct taaaactata aatatggatc ttttatgatt      540

ctttttgtaa gccctagggg ctctaaaatg gtttcactta tttatcccaa aatatttatt      600

attatgttga atgttaaata tagtatctat gtagattggt tagtaaaact atttaataaa      660

tttgataaat ataaacaaaa aaaaaaaaac cccccccc                              698


<210>  54
<211>  1311
<212>  DNA
<213>  Homo sapiens

<400>  54
gtaagtctgc tggcctccgc catcttagta aagtaacagt cccatgaaac aaagatgcag       60

tcgggcactc actggagagt tctgggcctc tgcctcttat cagttggcgt ttgggggcaa      120

gatggtaatg aagaaatggg tggtattaca cagacaccat ataaagtctc catctctgga      180

accacagtaa tattgacatg ccctcagtat cctggatctg aaatactatg gcaacacaat      240

gataaaaaca taggcggtga tgaggatgat aaaaacatag gcagtgatga ggatcacctg      300

tcactgaagg aattttcaga attggagcaa agtggttatt atgtctgcta ccccagagga      360

agcaaaccag aagatgcgaa cttttatctc tacctgaggg caagagtgtg tgagaactgc      420

atggagatgg atgtgatgtc ggtggccaca attgtcatag tggacatctg catcactggg      480

ggcttgctgc tgctggttta ctactggagc aagaatagaa aggccaaggc caagcctgtg      540

acacgaggag cgggtgctgg cggcaggcaa aggggacaaa acaaggagag gccaccacct      600

gttcccaacc cagactatga gcccatccgg aaaggccagc gggacctgta ttctggcctg      660

aatcagagac gcatctgacc ctctggagaa cactgcctcc cgctggccca ggtctcctct      720

ccagtccccc tgcgactccc tgtttcctgg gctagtcttg gaccccacga gagagaatcg      780

ttcctcagcc tcatggtgaa ctcgcgccct ccagcctgat cccccgctcc ctcctccctg      840

ccttctctgc tggtacccag tcctaaaata ttgctgcttc ctcttccttt gaagcatcat      900

cagtagtcac accctcacag ctggcctgcc ctcttgccag gatatttatt tgtgctattc      960

actcccttcc ctttggatgt aacttctccg ttcagttccc tccttttctt gcatgtaagt     1020

tgtcccccat cccaaagtat tccatctact tttctatcgc cgtccccttt tgcagccctc     1080

tctggggatg gactgggtaa atgttgacag aggccctgcc ccgttcacag atcctggccc     1140

tgagccagcc ctgtgctcct ccctccccca acactcccta ccaaccccct aatcccctac     1200

tccctccaac cccccctccc actgtaggcc actggatggt catttggcat ctccgtatat     1260

gtgctctggc tcctcagctg agagagaaaa aaataaactg tatttggctg c              1311


<210>  55
<211>  2406
<212>  DNA
<213>  Homo sapiens

<400>  55
gattctgtgt gtgtcctcag atgctcagcc acagaccttt gagggagtaa agggggcaga       60

cccacccacc ttgcctccag gctctttcct tcctggtcct gttctatggt ggggctccct      120

tgccagactt cagactgaga agtcagatga agtttcaaga aaaggaaatt ggtgggtgac      180

agagatgggt ggaggggctg gggaaaggct gtttacttcc tcctgtctag tcggtttggt      240

ccctttaggg ctccggatat ctttggtgac ttgtccactc cagtgtggca tcatgtggca      300

gctgctcctc ccaactgctc tgctacttct agtttcagct ggcatgcgga ctgaagatct      360

cccaaaggct gtggtgttcc tggagcctca atggtacagg gtgctcgaga aggacagtgt      420

gactctgaag tgccagggag cctactcccc tgaggacaat tccacacagt ggtttcacaa      480

tgagagcctc atctcaagcc aggcctcgag ctacttcatt gacgctgcca cagtcgacga      540

cagtggagag tacaggtgcc agacaaacct ctccaccctc agtgacccgg tgcagctaga      600

agtccatatc ggctggctgt tgctccaggc ccctcggtgg gtgttcaagg aggaagaccc      660

tattcacctg aggtgtcaca gctggaagaa cactgctctg cataaggtca catatttaca      720

gaatggcaaa ggcaggaagt attttcatca taattctgac ttctacattc caaaagccac      780

actcaaagac agcggctcct acttctgcag ggggcttttt gggagtaaaa atgtgtcttc      840

agagactgtg aacatcacca tcactcaagg tttggcagtg tcaaccatct catcattctt      900

tccacctggg taccaagtct ctttctgctt ggtgatggta ctcctttttg cagtggacac      960

aggactatat ttctctgtga agacaaacat tcgaagctca acaagagact ggaaggacca     1020

taaatttaaa tggagaaagg accctcaaga caaatgaccc ccatcccatg ggggtaataa     1080

gagcagtagc agcagcatct ctgaacattt ctctggattt gcaaccccat catcctcagg     1140

cctctctaca agcagcagga aacatagaac tcagagccag atcccttatc caactctcga     1200

cttttccttg gtctccagtg gaagggaaaa gcccatgatc ttcaagcagg gaagccccag     1260

tgagtagctg cattcctaga aattgaagtt tcagagctac acaaacactt tttctgtccc     1320

aaccgttccc tcacagcaaa gcaacaatac aggctaggga tggtaatcct ttaaacatac     1380

aaaaattgct cgtgttataa attacccagt ttagagggga aaaaaaaaca attattccta     1440

aataaatgga taagtagaat taatggttga ggcaggacca tacagagtgt gggaactgct     1500

ggggatctag ggaattcagt gggaccaatg aaagcatggc tgagaaatag caggtagtcc     1560

aggatagtct aagggaggtg ttcccatctg agcccagaga taagggtgtc ttcctagaac     1620

attagccgta gtggaattaa caggaaatca tgagggtgac gtagaattga gtcttccagg     1680

ggactctatc agaactggac catctccaag tatataacga tgagtcctct taatgctagg     1740

agtagaaaat ggtcctagga aggggactga ggattgcggt ggggggtggg gtggaaaaga     1800

aagtacagaa caaaccctgt gtcactgtcc caagttgcta agtgaacaga actatctcag     1860

catcagaatg agaaagcctg agaagaaaga accaaccaca agcacacagg aaggaaagcg     1920

caggaggtga aaatgctttc ttggccaggg tagtaagaat tagaggttaa tgcagggact     1980

gtaaaaccac cttttctgct tcaatatcta attcctgtgt agctttgttc attgcattta     2040

ttaaacaaat gttgtataac caatactaaa tgtactactg agcttcgctg agttaagtta     2100

tgaaactttc aaatccttca tcatgtcagt tccaatgagg tggggatgga gaagacaatt     2160

gttgcttatg aaagaaagct ttagctgtct ctgttttgta agctttaagc gcaacatttc     2220

ttggttccaa taaagcattt tacaagatct tgcatgctac tcttagatag aagatgggaa     2280

aaccatggta ataaaatatg aatgataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2400

aaaaaa                                                                2406


<210>  56
<211>  921
<212>  DNA
<213>  Homo sapiens

<400>  56
ttctatgcaa agcaaaaagc cagcagcagc cccaagctga taagattaat ctaaagagca       60

aattatggtg taatttccta tgctgaaact ttgtagttaa ttttttaaaa aggtttcatt      120

ttcctattgg tctgatttca caggaacatt ttacctgttt gtgaggcatt ttttctcctg      180

gaagagaggt gctgattggc cccaagtgac tgacaatctg gtgtaacgaa aatttccaat      240

gtaaactcat tttccctcgg tttcagcaat tttaaatcta tatatagaga tatctttgtc      300

agcattgcat cgttagcttc tcctgataaa ctaattgcct cacattgtca ctgcaaatcg      360

acacctatta atgggtctca cctcccaact gcttccccct ctgttcttcc tgctagcatg      420

tgccggcaac tttgtccacg gacacaagtg cgatatcacc ttacaggaga tcatcaaaac      480

tttgaacagc ctcacagagc agaagactct gtgcaccgag ttgaccgtaa cagacatctt      540

tgctgcctcc aagaacacaa ctgagaagga aaccttctgc agggctgcga ctgtgctccg      600

gcagttctac agccaccatg agaaggacac tcgctgcctg ggtgcgactg cacagcagtt      660

ccacaggcac aagcagctga tccgattcct gaaacggctc gacaggaacc tctggggcct      720

ggcgggcttg aattcctgtc ctgtgaagga agccaaccag agtacgttgg aaaacttctt      780

ggaaaggcta aagacgatca tgagagagaa atattcaaag tgttcgagct gaatatttta      840

atttatgagt ttttgatagc tttatttttt aagtatttat atatttataa ctcatcataa      900

aataaagtat atatagaatc t                                                921


<210>  57
<211>  4000
<212>  DNA
<213>  Homo sapiens

<400>  57
aagcttactc tctggcacca aactccatgg gatgattttt ccttcctaga agagtccagg       60

tggacaggta aggagtggga gtcagggagt ccagttccag ggacagagat tacgggataa      120

aaagtgaaag gagagggacg gggcccatgc cgagggtttc tcccttgttt ctcagacagc      180

tcttgggcca agactcaggg agacattgag acagagcgct tggcacagaa gcagaggggt      240

cagggcgaag tccagggccc caggcgttgg ctctcagggt ctcaggcccc gaaggcggtg      300

tatggattgg ggagtcccag ccttggggat tccccaactc cgcagtttct tttctccctc      360

tcccaaccta tgtagggtcc ttcttcctgg atactcacga cgcggaccca gttctcactc      420

ccattgggtg tcgggtttcc agagaagcca atcagtgtcg tcgcggtcgc ggttctaaag      480

tccgcacgca cccaccggga ctcagattct ccccagacgc cgaggatggc cgtcatggcg      540

ccccgaaccc tcgtcctgct actctcgggg gctctggccc tgacccagac ctgggcgggt      600

gagtgcgggg tcgggaggga aacggcctct gtggggagaa gcaacgggcc gcctggcggg      660

ggcgcaggac ccgggaagcc gcgccgggag gagggtcggg cgggtctcag ccactcctcg      720

tccccaggct ctcactccat gaggtatttc ttcacatccg tgtcccggcc cggccgcggg      780

gagccccgct tcatcgcagt gggctacgtg gacgacacgc agttcgtgcg gttcgacagc      840

gacgccgcga gccagaggat ggagccgcgg gcgccgtgga tagagcagga gggtccggag      900

tattgggacg gggagacacg gaaagtgaag gcccactcac agactcaccg agtggacctg      960

gggaccctgc gcggctacta caaccagagc gaggccggtg agtgaccccg gcccggggcg     1020

caggtcacga cctctcatcc cccacggacg ggccaggtcg cccacagtct ccgggtccga     1080

gatccgcccc gaagccgcgg gaccccgaga cccttgcccc gggagaggcc caggcgcctt     1140

tacccggttt cattttcagt ttaggccaaa aatcccccca ggttggtcgg ggcggggcgg     1200

ggctcggggg accgggctga ccgcggggtc cgggccaggt tctcacaccg tccagaggat     1260

gtatggctgc gacgtggggt cggactggcg cttcctccgc gggtaccacc agtacgccta     1320

cgacggcaag gattacatcg ccctgaaaga ggacctgcgc tcttggaccg cggcggacat     1380

ggcagctcag accaccaagc acaagtggga ggcggcccat gtggcggagc agttgagagc     1440

ctacctggag ggcacgtgcg tggagtggct ccgcagatac ctggagaacg ggaaggagac     1500

gctgcagcgc acgggtacca ggggccacgg ggcgcctccc tgatcgcctg tagatctccc     1560

gggctggcct cccacaagga ggggagacaa ttgggaccaa cactagaata tcgccctccc     1620

tctggtcctg agggagagga atcctcctgg gtttccagat cctgtaccag agagtgactc     1680

tgaggttccg ccctgctctc tgacacaatt aagggataaa atctctgaag gaatgacggg     1740

aagacgatcc ctcgaatact gatgagtggt tccctttgac acacacaggc agcagccttg     1800

ggcccgtgac ttttcctctc aggccttgtt ctctgcttca cactcaatgt gtgtgggggt     1860

ctgagtccag cacttctgag tccttcagcc tccactcagg tcaggaccag aagtcgctgt     1920

tccctcttca gggactagaa tttccacgga ataggagatt atcccaggtg cctgtgtcca     1980

ggctggtgtc tgggttctgt gctcccttcc ccatcccagg tgtcctgtcc attctcaaga     2040

tagccacatg tgtgctggag gagtgtccca tgacagatcg aaaatgcctg aatgatctga     2100

ctcttcctga cagacgcccc caaaacgcat atgactcacc acgctgtctc tgaccatgaa     2160

gccaccctga ggtgctgggc cctgagcttc taccctgcgg agatcacact gacctggcag     2220

cgggatgggg aggaccagac ccaggacacg gagctcgtgg agaccaggcc tgcaggggat     2280

ggaaccttcc agaagtgggc ggctgtggtg gtgccttctg gacaggagca gagatacacc     2340

tgccatgtgc agcatgaggg tttgcccaag cccctcaccc tgagatgggg taaggaggga     2400

gacgggggtg tcatgtcttt tagggaaagc aggagcctct ctgaccttta gcagggtcag     2460

ggcccctcac cttcccctct tttcccagag ccgtcttccc agcccaccat ccccatcgtg     2520

ggcatcattg ctggcctggt tctctttgga gctgtgatca ctggagctgt ggtcgctgct     2580

gtgatgtgga ggaggaagag ctcaggtggg gaaggggtga agggtgggtc tgagatttct     2640

tgtctcactg agggttccaa gacccaggta gaagtgtgcc ctgcctcgtt actgggaagc     2700

accacccaca attatgggcc tacccagcct gggccctgtg tgccagcact tactcttttg     2760

taaagcacct gttaaaatga aggacagatt tatcaccttg attacagcgg tgatgggacc     2820

tgatcccagc agtcacaagt cacaggggaa ggtccctgag gaccttcagg agggcggttg     2880

gtccaggacc cacacctgct ttcttcatgt ttcctgatcc cgccctgggt ctgcagtcac     2940

acatttctgg aaacttctct gaggtccaag acttggaggt tcctctagga ccttaaggcc     3000

ctgactcttt tctggtatct cacaggacat tttcttccca cagatagaaa aggagggagc     3060

tactctcagg ctgcaagtaa gtatgaagga ggctgatgcc tgaggtcctt gggatattgt     3120

gtttgggagc ccatggggga gctcacccac cccacaattc ctcctctagc cacatcttct     3180

gtgggatctg accaggttct gtttttgttc taccccaggc agtgacagtg cccagggctc     3240

tgatgtgtct ctcacagctt gtaaaggtga gagcctggag ggcctgatgt gtgttgggtg     3300

ttgggcggaa cagtggacac agctgtgcta tggggtttct ttccattgga tgtattgagc     3360

atgcgatggg ctgtttaaag tgtgacccct cactgtgaca gatacgaatt tgttcatgaa     3420

tatttttttc tatagtgtga gacagctgcc ttgtgtggga ctgagaggca agagttgttc     3480

ctgcccttcc ctttgtgact tgaagaaccc tgactttgtt tctgcaaagg cacctgcatg     3540

tgtctgtgtt cgtgtaggca taatgtgagg aggtggggag accaccccac ccccatgtcc     3600

accatgaccc tcttcccacg ctgacctgtg ctccctcccc aatcatcttt cctgttccag     3660

agaggtgggg ctgaggtgtc tccatctctg tctcaacttc atggtgcact gagctgtaac     3720

ttcttccttc cctattaaaa ttagaacctg agtataaatt tactttctca aattcttgcc     3780

atgagaggtt gatgagttaa ttaaaggaga agattcctaa aatttgagag acaaaataaa     3840

tggaacacat gagaaccttc cagagtccac gtgttgctta tgctgatttg ttgcagggga     3900

ggagagtaga tggggctgtg cccagtttct gttccggcca ctatgggctt tatgtggtca     3960

ctgcttggct gggtcatctt tgctgctcca ttgtccttgg                           4000


<210>  58
<211>  1601
<212>  DNA
<213>  Homo sapiens

<400>  58
aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg       60

gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc      120

acccacttcc caggcaacct gcctaacatg cttcgagatc tccgagatgc cttcagcaga      180

gtgaagactt tctttcaaat gaaggatcag ctggacaact tgttgttaaa ggagtccttg      240

ctggaggact ttaagggtta cctgggttgc caagccttgt ctgagatgat ccagttttac      300

ctggaggagg tgatgcccca agctgagaac caagacccag acatcaaggc gcatgtgaac      360

tccctggggg agaacctgaa gaccctcagg ctgaggctac ggcgctgtca tcgatttctt      420

ccctgtgaaa acaagagcaa ggccgtggag caggtgaaga atgcctttaa taagctccaa      480

gagaaaggca tctacaaagc catgagtgag tttgacatct tcatcaacta catagaagcc      540

tacatgacaa tgaagatacg aaactgagac atcagggtgg cgactctata gactctagga      600

cataaattag aggtctccaa aatcggatct ggggctctgg gatagctgac ccagcccctt      660

gagaaacctt attgtacctc tcttatagaa tatttattac ctctgatacc tcaaccccca      720

tttctattta tttactgagc ttctctgtga acgatttaga aagaagccca atattataat      780

ttttttcaat atttattatt ttcacctgtt tttaagctgt ttccataggg tgacacacta      840

tggtatttga gtgttttaag ataaattata agttacataa gggaggaaaa aaaatgttct      900

ttggggagcc aacagaagct tccattccaa gcctgaccac gctttctagc tgttgagctg      960

ttttccctga cctccctcta atttatcttg tctctgggct tggggcttcc taactgctac     1020

aaatactctt aggaagagaa accagggagc ccctttgatg attaattcac cttccagtgt     1080

ctcggaggga ttcccctaac ctcattcccc aaccacttca ttcttgaaag ctgtggccag     1140

cttgttattt ataacaacct aaatttggtt ctaggccggg cgcggtggct cacgcctgta     1200

atcccagcac tttgggaggc tgaggcgggt ggatcacttg aggtcaggag ttcctaacca     1260

gcctggtcaa catggtgaaa ccccgtctct actaaaaata caaaaattag ccgggcatgg     1320

tggcgcgcac ctgtaatccc agctacttgg gaggctgagg caagagaatt gcttgaaccc     1380

aggagatgga agttgcagtg agctgatatc atgcccctgt actccagcct gggtgacaga     1440

gcaagactct gtctcaaaaa aataaaaata aaaataaatt tggttctaat agaactcagt     1500

tttaactaga atttattcaa ttcctctggg aatgttacat tgtttgtctg tcttcatagc     1560

agattttaat tttgaataaa taaatgtatc ttattcacat c                         1601


<210>  59
<211>  12150
<212>  DNA
<213>  Ricinus communis

<400>  59
atatttcacg aactgataca atatagcaag agattgaaaa aactcaaatt cttacaaaac       60

tgaactgaaa taaaacaaga gatgcataat aaaaaaatac aaatcttgat acttattaca      120

actggaatat gcgactaagc tgaaataaac tgacattaaa gacatgacag aaatacatgt      180

tttggtctat aacaacctaa gtagaaatcg cagcctgttg atgcacagat acatgtattc      240

ttatatattt gtattaatat tttaatttat gtacatatcg agatgaatga aaataagcta      300

atatttgtca tttagaaatt attccaaaac tgaatcatct tacttgagtt atttaattaa      360

taaaattaaa tatatttcat taaacaatgc attttctctt taaaacaatc catttgaatc      420

ttactttata ggaagacctt gatagataaa caatgtattg gatatacgtt ttttttagat      480

gctctaaaga ttgcattaga atgaaataaa actttttact tttaagattt ttgctcttta      540

aaataaaaag tacaaacttt gataagtttt atataaccta aaaagaaatt gtaacatgtg      600

agtttgagat gtcttatata atctacaaag atatttaaag agtataaaca gtaaagcaat      660

aatacttagg tgatgaaaat acctcactta gtactaatac aacaaagcaa gatatcgaac      720

aaatcttaaa tctttgcaaa actgaactga agtaaaacaa gaaatgcata ataataagac      780

aaatcttgga acttattata gctggaatat gccagtaagc tgaaataaat tgatactaag      840

gacacaacag aaacacatgc gtctgcaacc taagaagaag ttgcaacctg tcgatgcata      900

aatatacata tgcgacgtat attgctatgt atgaaaataa gcgaatactt atcatttgga      960

atttattcca aaattggatc atcttgctga gttattcaat taataataat gaatatattt     1020

tattaagaaa taaaaaattt accttttcct ctttaaaacg atttatttga atattacttt     1080

atgagaagac tttttataat cagaaaactt gatatataaa gaatgtattt gataatgttt     1140

ctttagagat gctctaaaga ttgtattgca cttaaataaa accttttact cttaatagtt     1200

tagtatttct caaaattatt actctttaaa gtaaatagct caaactttga gaagtcttat     1260

gtaaactaaa caaaaattgt aacctacgag tttgagatgt cttatacaac ctaaaataaa     1320

atttaaagaa tataaacttt aagatgtctt tttctatata atcaatttta ttttgaaaaa     1380

ccaccaaagc aaaaaaaatt taggtgatgg aaatatccta cctagaacta ataaaatata     1440

gcaaaagatt aaacaaatct caaattctta taaaattgaa ctgaagtaaa acaagagatg     1500

tataataaca aattttggta cttaatacaa aaatatgtca ttaagctaaa gtaaagtgat     1560

aataaggaca caatataaac acatgctttg gcctccagca atctaataag aaattgcaac     1620

ctatcgatgc acaaatacac gtatctttat atgcttatat aagtatttta atttgtgtac     1680

gtgtattcaa atgactgaaa ataaactaaa acttgtcata taaaattttt tcaaaattaa     1740

atgatcttgc taagttattc actaataata ataaatatat ttcattaaaa ataaaaattt     1800

gtcctttctc tataaaagag tccattagaa tcttactata tatgaaggct ttttataatt     1860

aaaaaacttg atatataaag aatgtattgg aggtgcattt tttttttgag atgttctgaa     1920

gattgcattg gactacaata aaagttttta cttttacttc ttagaattct tgctctttaa     1980

aataataagc acaaactttg agatgtcttg tagaacctaa gaaaaaaatt acaatttgtg     2040

atttttagat gttttataca atctaaaaag agatttgaag agtataaatt ttaagatgtt     2100

ttatacaacc taaaacaaat tgtaatctgt cgacgcacag acacgtattt ttatatattt     2160

ataaagatca ttttaattta tgtacttata tttagataaa taaaaataag ctaatatttg     2220

tcatatataa attatttcat aactgaattg tctgatttgt tagtgttatt aaattaataa     2280

taatagttat attttattaa ataataaaag atttaccttt tctctataaa aaggggaaga     2340

aatgtggtta ctaaaaccat ctcatattcc tccgctttct tcctcagctg ctcactttgt     2400

aagtattacg actttctcaa acttcctact tgttttcaat taatgttatt ctacctgact     2460

tcatatatat ctcttttctt ttgggatcat tattactgct actgtaatga tcgagaaaaa     2520

tctcttcttc ttatcattat gacttcatat attatcatct tctatcactt catataatgt     2580

ttttgatttt atgattcaat atatttataa ttaagttcta tctttaaacg agagcaacca     2640

attaaagaaa caagagtaaa tatatataaa ttgtaaggta ttatttgttt gatttaaatc     2700

attaaatagc tagatcttct ttttcttttc tttttttctt tctcatccaa agtttttatg     2760

aattgcaggc tattagtaat atagatggta gaaagaaaat taaaattaaa acttcttcaa     2820

tcatcacaaa tgagagtacc aactaaacta tgtgattttg gtaaaaaatg caaaacaagt     2880

acttatatat atatatatat atatatatat atatatatat atatatatat tcttttataa     2940

atcagtatat acattttact ctgattacca taatattata gattttacta aggtgacact     3000

aatgttatat attttggtta gaatggtagt gttttctttt cttaaagatg ctctagagga     3060

ttcttaacaa aagaatataa tatataaata atatattaaa gatgccctag aaaatgcatt     3120

tactgtactt aaataacctg ttttgctctt aatattttat tatttttatt tctataataa     3180

aaaatatttt aagaaatatt taagtataaa aaataaagta ttttattgat gtccactgta     3240

ctttttatat tttatttctt attttacttt tgtttccaag ggcatcaata tcttcttctt     3300

ttttctgttt aatttttatt aataaaaaaa ataattacaa atattaatta atcaaataca     3360

tagaaattta tttttataaa aaaaatcctt caaattcttt taaaatgtca ttttgaccct     3420

aaatttcttt taatagttag tgttctaata aaaaaaattt acccaataat ttttctaata     3480

tttcattatt cttttataag acaaactctt agcctctaga attattttaa ggatatatat     3540

aatttgtctc tctttctctt taacatagcc ttagtttcca ataaataaat aatgaaatat     3600

atttcactct tcatttcttt aaacttctta catttttttt tgtagcattc tttgtaagtg     3660

gaatgacaaa accgttaatg atgttctttt aaaagtgaaa gatgtttata tattgcagta     3720

cagataatga tatatctact gcactacata aaacaattta aatctccctg tttattttaa     3780

gaagttatat tttctttctt tctcatccta agaaagttaa attactgtaa tcgacattat     3840

atgaatttta actaattccg tttctaattt ataattattt cgttaaacca atcaattccc     3900

tttaaacact gcttatgcat attctgtctc aatttatata tggcatgcat cttccgtatt     3960

aatttataag ttcattttta ttgatcaagt atttgtggtt ttctttatat aaaaaaatgt     4020

attagtgttt ttctgtatta attttataag ttcatcttta tgagaatgct aatgtatttg     4080

gacagccaat aaaattccaa gaattgctgc aatcaaagat gaaaccggga ggaaatacta     4140

ttgtaatatg gatgtatgca gtggcaacat ggctttgttt tggatccacc tcagggtggt     4200

ctttcacatt agaggataac aacatattcc ccaaacaata cccaattata aactttacca     4260

cagcgggtgc cactgtgcaa agctacacaa actttatcag agctgttcgc ggtcgtttaa     4320

caactggagc tgatgtgaga catgaaatac cagtgttgcc aaacagagtt ggtttgccta     4380

taaaccaacg gtttatttta gttgaactct caaatcatgc agagctttct gttacattag     4440

cgctggatgt caccaatgca tatgtggtcg gctaccgtgc tggaaatagc gcatatttct     4500

ttcatcctga caatcaggaa gatgcagaag caatcactca tcttttcact gatgttcaaa     4560

atcgatatac attcgccttt ggtggtaatt atgatagact tgaacaactt gctggtaatc     4620

tgagagaaaa tatcgagttg ggaaatggtc cactagagga ggctatctca gcgctttatt     4680

attacagtac tggtggcact cagcttccaa ctctggctcg ttcctttata atttgcatcc     4740

aaatgatttc agaagcagca agattccaat atattgaggg agaaatgcgc acgagaatta     4800

ggtacaaccg gagatctgca ccagatccta gcgtaattac acttgagaat agttggggga     4860

gactttccac tgcaattcaa gagtctaacc aaggagcctt tgctagtcca attcaactgc     4920

aaagacgtaa tggttccaaa ttcagtgtgt acgatgtgag tatattaatc cctatcatag     4980

ctctcatggt gtatagatgc gcacctccac catcgtcaca gttttctttg cttataaggc     5040

cagtggtacc aaattttaat gctgatgttt gtatggatcc tgagcccata gtgcgtatcg     5100

taggtcgaaa tggtctatgt gttgatgtta gggatggaag attccacaac ggaaacgcaa     5160

tacagttgtg gccatgcaag tctaatacag atgcaaatca gctctggact ttgaaaagag     5220

acaatactat tcgatctaat ggaaagtgtt taactactta cgggtacagt ccgggagtct     5280

atgtgatgat ctatgattgc aatactgctg caactgatgc cacccgctgg caaatatggg     5340

ataatggaac catcataaat cccagatcta gtctagtttt agcagcgaca tcagggaaca     5400

gtggtaccac acttacagtg caaaccaaca tttatgccgt tagtcaaggt tggcttccta     5460

ctaataatac acaacctttt gtgacaacca ttgttgggct atatggtctg tgcttgcaag     5520

caaatagtgg acaagtatgg atagaggact gtagcagtga aaaggctgaa caacagtggg     5580

ctctttatgc agatggttca atacgtcctc agcaaaaccg agataattgc cttacaagtg     5640

attctaatat acgggaaaca gttgtcaaga tcctctcttg tggccctgca tcctctggcc     5700

aacgatggat gttcaagaat gatggaacca ttttaaattt gtatagtggg ttggtgttag     5760

atgtgagggc atcggatccg agccttaaac aaatcattct ttaccctctc catggtgacc     5820

caaaccaaat atggttacca ttattttgat agacagatta ctctcttgca gtgtgtatgt     5880

cctgccatga aaatagatgg cttaaataaa aaggacattg taaattttgt aactgaaagg     5940

acagcaagtt attgcagtcc agtatctaat aagagcacaa ctattgtctt gtgcattcta     6000

aatttatgga tgaattgtat gaattaagct aattattttg gtcatcagac ttgatatctt     6060

tttgaataaa ataaataata tgttttttca aacttataaa actatgaatg atatgaatat     6120

aatgcggaga ctagtcaatc ttttatgtaa ttctatgatg ataaaagctt gtctcttaac     6180

ttagtgaatt tgtatccaag taaaaaacag cctactaagt catggattcc ttcaaattta     6240

cgctcttatt ataagcttaa ttttcatcca cgatcatccc tattcatgtg atgcacaaga     6300

acttaaggta tatagatttg aagtaattcc ttaattataa tttttaagtt tatcactttc     6360

tttactttct aatttctttt tctcaaattg tactaattaa ctcattgaag aatttaacaa     6420

cttgttcatc agttccatag taattctcaa taaatttatg gtctcacaac tcaagcatcc     6480

atgggttcat aagttgtgat aatcaggcag cttcatatat attgaaatta acataaggag     6540

taaagtgggt tgagcaatgc caggtggtac atccaggtgg tacatccata tatacttctt     6600

cctccaaatc accatgtaaa aaagtatttt ttacatcaaa ttgtcttaat gcccatcctt     6660

tagttgctgc aatagaaatc agtattcaaa tcgtaccaag tttcgccaca ggtgcaaacg     6720

tttcctggta gtcaattcca tacttctgag taaatccttt cgctaccagt ctcgcttttc     6780

gcctgtctag actcccatct gccttaagct tcactgtata gatccattta cagccaatcg     6840

tattcttccc ctctggtaat ttcacaaact cccatgttgc attcttctct agggctttca     6900

cctcttcctc catcgcctct tttcatttca agtcttgcat tgcctcctgc acactattag     6960

gaatcgcaat cccggataat tcactagtgc taagtgcata ataatctgtt aaatgattat     7020

gtcgaatacc attcttagtt aaaaaattac ttaaatgact atccataaat tcctttgcat     7080

tatcagtttg ccaaactaaa acccatgtac gatattgatt tctaataaaa tttcaaaaat     7140

cacaaaaagc tttacttacc tcacttttgt tccgaagtaa ggttatccaa gtcatacgag     7200

tacattcgtc tataaaagtt ccgaaatatc tagcacctga taatgaagga atttttgcag     7260

gaccccaaac atcagaatgt ataacagcaa atggttcagt acttttatta aaactaggca     7320

aataagtagc acggtggctc ttaccaagtt cacacacatc acaattaaac acggaatcat     7380

ccaaattaac aaacaattca ggttttaatt ttttcaaata actaaatgac aaatgtccaa     7440

ggcgtcgatg ccatagccaa attctttcca ttgtattact taagctttca gtcgtgtaaa     7500

cctcacttat tttcttctct cctatctcag tcaagtctag ataataaagt ttgcctcgtt     7560

taacaccata accaagagtc tcccgagtca ggatgtcctg aaaaacacaa tatgaaggcc     7620

agaaagttac agtacagtta agagacgagg ttatttgtcc aaccgagagt aagttacaag     7680

acagtgtaag aacaatcaat acagatttta aattcagatt ttttgaaaga gtaatggatc     7740

cttctccact aacaatacat ttggatccat ttgttattga cacggtaaaa tgagaggatg     7800

gaatgaaaga ataaattcga tcagaattgc ataccatatg atcagatgca ccagggtcta     7860

ttgtccacaa tgttcacaca gcaagttaca tttttttcca gctccatttt tcctgttttt     7920

tccataattc tggcaaacct gaaatacagt aggctccaca gttgcatttg ttcctcccat     7980

tgtcttacat tgttgatctt ctcttcgaac ataagcatat gtttgttcta aatcaagttt     8040

agggtctttg cgcaaaatct cacctcggac ttgatcaaag tttgaatcaa gcccactgag     8100

gaagatatgc atgcgtagcc ttgccatggc agaatgcaac gctactactc catccactgt     8160

accttcatgt gactgagtac gatgatctat ctcttgaaag atttccatca actcagagta     8220

atacgtaggc aatggtctgc cctcttgttt gattgcgaaa gacttctgat tcaattcgaa     8280

taacctcgtt tcatcagttc catcataaaa tgtttttgct gctgcctccc aaacatcttt     8340

ggcagtagga agtctgatga aatgttgcat cagtgaaggt atcatcgaat caatcagcca     8400

gctctttacc ttttgattct cagttatcca ggtagagtat ctcgtatctg tagttgcagg     8460

cttcacttcc gatccggtta aatacccagt tttatttcgt gctccaatac gcatctccat     8520

gagctgtgac catagagaat aattcgattc atccagtata acactggtag ggaatgatac     8580

attatcttgt tgaatgataa tttgattcga agacggattc atgatttgag tatgaggtgg     8640

atcttctgta ctcataattc tgtttaggga ttcagttttg atttgaaaaa aatttgtttt     8700

cagtatggtg agcggctgtt gtgataccat gtgagtaatg aaactctaat aattgattaa     8760

ttttcatcct ttttctctat tcattcaacc tgaatatata caaaagtttg ttacaaggat     8820

aacttctaac tacttatgta acaagcaacc ttatcaaaaa tacaattaga ataacatcta     8880

actactacag cttatacata cttatctcta tactaacaaa ttaactaaat atagttaaca     8940

agttctgaat catagtaatt ttagtctcta taatattaac aaatgaggga ctaaaatact     9000

tttcttttct taaatatgat tctattttaa aaagcgggag atagaaaaat ttatataatt     9060

tcttactaaa aaaaagtaag gataatttta tttaattcta agaaacaaag caaaggaaaa     9120

tgggaaagtt tataatttga tctaatttct ttgcatgata gacaggtaac tgattctcaa     9180

tacgattcta agatgatcca atataaatta tttgtgggaa ataggttcac gaaaaagcca     9240

tttgttgggg attcaatgtt tattgatttg ttttgtgtag tatgttttgc atcaattaat     9300

tagatcagct agtcatttac atattcttgc aaatttgtgc catttacaaa tgaattatct     9360

gaatttagtg taatttgatt aatttaatta gacgggtttt ccttcttcag taatcaacat     9420

acacaaagtg aaaggcaaac gagttctagc aatttaattg attaggttca agttaattaa     9480

ttaatttgat aatttatggt tcagtccgtt actgaaaatt taaaaagaag tagcatgcat     9540

ctttagattc tttctctatt ttatgcatgc cattttctga ttaattgtat atgttcgttc     9600

ttcttgatta agtatttata tttatttttt atttgattag tgagctatat atatttttaa     9660

gagaatcttg atgtatttgg acaactaaaa aaattccaag aattgctaca attggagatg     9720

aaactgaaag gaaacactat ggtgtggata tacgcagtgg caacgtggct ctgcttggga     9780

tcagccttgg ggtggtaatt caatgccact gtaagctaca cattcccaac tgtaagcttt     9840

accactgttg atgccacgga gcaaatgtac agagagtgtt gtagaaaata agaataagta     9900

tatatactta tcggcttagt agccaagaag tcttttggta acctacaact cttaaacatc     9960

atatacttaa tacataagtt acacgcttaa tgaatatata tgtaacttac atatttaata    10020

ggtgactctt taatttcata acttaagcat taaaaactat acataatgat tattaaatta    10080

aatttagttt ttcaacactc cttaaattta atttcagatc aaaccgagtc ttgctcttaa    10140

tctggcaaaa tcttcaaact ttaatgcctt cgtcaaaata tcagcaagtt gatcttgcga    10200

cttgacatac ttcagctcta tttccttctt acggatactt tctctgatga aatgatatct    10260

tctattaatg tatttactct taacatgtaa aataggattc ttgctcaatg ctatagacga    10320

tttattatca ataaaaatat caattggttc ttcgtttgaa accaatagca cctctaacac    10380

ctttcttaac catgtggcat gacaaacaca agcagcagca acaacatact taacttcaca    10440

agttgaaaga attacaatag attacttctt tgaactccat gtaaaagcag tctctccaat    10500

agaaaacaca aaacccattg tactctttcg atcatcaata tcacctcctc aatcactatc    10560

actatagcct actagactga aactttttga aggtgagtaa aacaaaccat aatctaaagt    10620

tccttcgaca tatctcaaaa ttcttttacc agccttcatg tgcgaatctg ttggtgcctc    10680

catgtagcga ctaataagtc ctactccata aagaatatca ggtctagtac aagtcaagta    10740

cctcaagttt ccaacaaatc tttgaaacaa aattggattc accttctcag tattatcata    10800

tcttgacagc tttactccac attcaactag tgtgctgaca agctgacatt gctccatgcc    10860

aaactccttt aagatctttc ttacatagct cttgtgagaa ataaaaatgc catcattagt    10920

ttgtttcact ttgattccca gataataaga catcaaccct atatctgtca tctcaaattc    10980

agcagccatc tcctttttga attattcaat cattgctgaa ttatttttct gtaaagatca    11040

aatcatcaac atacaagcac accacaagaa catcaccatt ctctttcttc ttagaataaa    11100

gagaatattc atgaggatat ttcagaaaat ttttcttttt gaaataatca tcaatcctgt    11160

tgtaccatgc ccttagtact tgcttcaatc catacaaagg taccttcagt tttaaaactt    11220

tgttttcttc ccctctaaca acatatctga aaggttgttt tagatatcct tcttcttcta    11280

agtatccatt caagaacgcc gatttcacgt ccatttgaaa aattcttcat ctcttttgtg    11340

cagctaaagc aatgattaaa caaattattt ccaatcgagc aactactaca aagacttcat    11400

catagtcaat tccatgttgt tggctaaacc cttttgcaac aagtcgagcc ttgtatttct    11460

cgacatctcc gttttcattc tttttaactt tttataaatc catttcacac caacaacttg    11520

cttgccttag gaaagattgc taattcccaa gtgtcattct tttgaattga ttttatttcg    11580

tcatctatgg ctactctcca tttttcattt ttcatcgctt cttcaaaatt cattggttca    11640

gtatctgcag aaatacaata atgaacaaaa tctaaaactt catcaatgtt agcatatatg    11700

tcctacagat ttctcatctt tgtaggtttt tcagatgatc ttgaacgact tgaatctcct    11760

tgaatacttg ctggagttct tggaagtgtc aagttctgta catcaaaatt aaaatgttga    11820

acatcttgat ctgaataatc aaaaattgga aaaaaattat aattttctga ttgattctcc    11880

caatttcatc catcagcttc ctcaaacttg acatctcgac tcaggataat ctttttgctt    11940

gtcggattgt acaacttgta gactttagac tttgcatcat atccaacaaa aatgaatttt    12000

ccacttttat catccagctt aattctggtt tcatctgcaa catgaacata agcaacataa    12060

ccaaaaactc taagatgaga aagagttggc tttcttccac tccatgcttc ctgtggtata    12120

gacttctgca aactctttat aggacatatg                                     12150


<210>  60
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  60
tcctcagcta gcaccaaggg accatcggtc ttccccctg                              39


<210>  61
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  61
gcagggtgta cacctgtggt tc                                                22


<210>  62
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  62
actgaacctt ggagtcaggt accacattga ttattgagta gttattaata g                51


<210>  63
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  63
gggcccctgt ggagagaaag gcaaagtgga tg                                     32


<210>  64
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  64
ctttgccttt ctctccacag gggcccactc cgacattgtg ctgacccaat c                51


<210>  65
<211>  67
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  65
cggtttaaaa aacgggacct ctggagcggc cgcttattaa cactctcccc tgttgaagct       60

ctttgtg                                                                 67


<210>  66
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  66
tccagaggtc ccgtttttta aaccggtttt ttaaaccgct gatcagcctc g                51


<210>  67
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  67
tagctcgatc cgtcgagaga attcccccag catgcctgct attg                        44


<210>  68
<211>  657
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Light chain of anti-streptavidin (anti-SA)

<400>  68
atggatatcg tgctgactca gccaccctca gcgtctggga cccccgggca gagggtcacc       60

ctctcttgta ctggaagcag ctccaacatc ggaagttatt ctgtaagctg gtaccagcag      120

cttccaggaa cggctcccaa actcctcatc tatgacaata ataagcgacc ctcaggggtc      180

tctgaccggt tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgc cagtcctatg acagcagcct gactggttcc      300

gtggtattcg gcggaggcac ccagctcacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggcct ggaaggcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctgcagaatg ttcttaa         657


<210>  69
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain of anti-streptavidin (anti-SA)

<400>  69

Met Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Leu Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser 
            20                  25                  30          


Tyr Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Thr Gly Ser Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
    210                 215             


<210>  70
<211>  657
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Light chain of anti-PE clone B11

<400>  70
atggatatcg tgctgactca gccaccctca gcgtctggga cccccgggca gagggtcacc       60

atctcttgct ctggaaccag cagtgatgtt gggaattcta accttgtctc ttggtaccag      120

cagctcccag gaacggctcc caaactcctc atttatggga acagcaatcg gccctcaggg      180

gtccctgacc ggttctctgg ctccaagtct ggcacctcag cctccctggc catcagtggg      240

ctgcggtccg aggatgaggc tgattattac tgctgctcat atgcaggtac tggctcccct      300

gatgtcttcg gaactggcac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggcct ggaaggcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctgcagaatg ttcttaa         657


<210>  71
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain of anti-PE clone B11

<400>  71

Met Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Ile Ser Cys Ser Gly Thr Ser Ser Asp Val Gly Asn 
            20                  25                  30          


Ser Asn Leu Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
65                  70                  75                  80  


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly 
                85                  90                  95      


Thr Gly Ser Pro Asp Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
    210                 215             


<210>  72
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain of anti-streptavidin (anti-SA)

<400>  72
atggaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga       60

ctctcctgtg cagcctctgg attcaccttc agtggctact ggatgcactg ggtccgccag      120

gctccaggca aggggctgga gtgggtttca gaaattagtg gtagtggtga tagcacacac      180

tacggagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg      240

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcaagagga      300

cggaacggat ccctcgacta ctggggccag ggcaccctgg tcacagtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gagaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtgc accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgag ctgcgcggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct cgttagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtccccggg taaatga                                         1347


<210>  73
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain of anti-streptavidin (anti-SA)

<400>  73

Met Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly 
            20                  25                  30          


Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Glu Ile Ser Gly Ser Gly Asp Ser Thr His Tyr Gly Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Asn Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Arg Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  74
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain of anti-PE clone B11

<400>  74
atggaggtgc agctgttgga gactggggga ggcttggtac agcctggggg gtccctgaga       60

ctctcctgtg cagcctctgg attcaccttt gacaactatg ccataaactg ggtccgccag      120

gctccaggca aggggctgga gtgggtctca ggtattagtt ggaatagtgg tagcataggc      180

tatgcggact ctgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg      240

tatctgcaaa tgaacagcct gagagccgag gacacggccg tatattactg tgcgagaggg      300

gccccccact acggtgggag gggggagttt gacttctggg gccagggcac cctggtcacg      360

gtctcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggagac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtgcaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgagctgcg cggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctcgtta gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtcc ccgggtaaat ga                        1362


<210>  75
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain of anti-PE clone B11

<400>  75

Met Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn 
            20                  25                  30          


Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ala Pro His Tyr Gly Gly Arg Gly Glu Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Arg Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


