                         SEQUENCE LISTING

<110>  The University of British Columbia
       Gleave, Martin
 
<120>  COMBINATION OF ANTI-CLUSTERIN OLIGONUCLEOTIDE WITH ANDROGEN 
       RECEPTOR ANTAGONIST FOR THE TREATMENT OF PROSTATE CANCER

<130>  2609/82682-A-PCT/JPW/GJG/REB

<150>  U.S. 61/452,583
<151>  2011-03-14

<150>  U.S. 61/453,309
<151>  2011-03-16

<150>  U.S. 61/453,885
<151>  2011-03-17

<150>  U.S. 61/493,336
<151>  2011-06-03

<160>  50    

<170>  PatentIn version 3.3

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1
gcacagcagg agaatcttca t                                               21


<210>  2
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2
tggagtcttt gcacgcctcg g                                               21


<210>  3
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3
cagcagcaga gtcttcatca t                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4
attgtctgag accgtctggt c                                               21


<210>  5
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5
ccttcagctt tgtctctgat t                                               21


<210>  6
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6
agcagggagt cgatgcggtc a                                               21


<210>  7
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7
atcaagctgc ggacgatgcg g                                               21


<210>  8
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  8
gcaggcagcc cgtggagttg t                                               21


<210>  9
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  9
ttcagctgct ccagcaagga g                                               21


<210>  10
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  10
aatttagggt tcttcctgga g                                               21


<210>  11
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  11
gctgggcgga gttgggggcc t                                               21


<210>  12
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  12
ggtgtagacg ccgcacg                                                    17


<210>  13
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  13
gcagcgcagc ccctgg                                                     16


<210>  14
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  14
gcagcagccg cagcccggct cc                                              22


<210>  15
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  15
agccgcagcc cggctcct                                                   18


<210>  16
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  16
cagcagccgc agcccggctc                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  17
cagcagccgc agcccggctc                                                 20


<210>  18
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  18
agcagccgca gcccggctcc                                                 20


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  19
ccagagcucg cccuucuact t                                               21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  20
guagaagggc gagcucuggt t                                               21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  21
gaugcucaac accuccucct t                                               21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  22
ggaggaggug uugagcauct t                                               21


<210>  23
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  23
uaauucaaca aaacugutt                                                  19


<210>  24
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  24
gacaguuuua uugaauuagt t                                               21


<210>  25
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  25
uaauucaaca aaacugutt                                                  19


<210>  26
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  26
acaguuuugu ugaauuatt                                                  19


<210>  27
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  27
augaugaaga cucugcugct t                                               21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  28
gcagcagagu cuucaucaut t                                               21


<210>  29
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  29
ugaaugaagg gacuaaccug tt                                              22


<210>  30
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  30
cagguuaguc ccuucauuca tt                                              22


<210>  31
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  31
cagaaauaga caaagugggg tt                                              22


<210>  32
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  32
ccccacuuug ucuauuucug tt                                              22


<210>  33
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  33
acagagacua agggaccaga tt                                              22


<210>  34
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  34
acagagacua agggaccaga tt                                              22


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  35
ccagagcucg cccuucuact t                                               21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  36
guagaagggc gagcucuggt t                                               21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  37
gucccgcauc guccgcagct t                                               21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  38
gcugcggacg augcgggact t                                               21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  39
cuaauucaau aaaacuguct t                                               21


<210>  40
<211>  21
<212>  DNA
<213>  RNAi for human clusterin

<400>  40
gacaguuuua uugaauuagt t                                               21


<210>  41
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  41
augaugaaga cucugcugc                                                  19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  RNAi for human clusterin

<400>  42
gcagcagagu cuucaucau                                                  19


<210>  43
<211>  2877
<212>  DNA
<213>  Homo sapiens

<400>  43
gctttccgcg gcattctttg ggcgtgagtc atgcaggttt gcagccagcc ccaaaggggg     60

tgtgtgcgcg agcagagcgc tataaatacg gcgcctccca gtgcccacaa cgcggcgtcg    120

ccaggaggag cgcgcgggca cagggtgccg ctgaccgagg cgtgcaaaga ctccagaatt    180

ggaggcatga tgaagactct gctgctgttt gtggggctgc tgctgacctg ggagagtggg    240

caggtcctgg gggaccagac ggtctcagac aatgagctcc aggaaatgtc caatcaggga    300

agtaagtacg tcaataagga aattcaaaat gctgtcaacg gggtgaaaca gataaagact    360

ctcatagaaa aaacaaacga agagcgcaag acactgctca gcaacctaga agaagccaag    420

aagaagaaag aggatgccct aaatgagacc agggaatcag agacaaagct gaaggagctc    480

ccaggagtgt gcaatgagac catgatggcc ctctgggaag agtgtaagcc ctgcctgaaa    540

cagacctgca tgaagttcta cgcacgcgtc tgcagaagtg gctcaggcct ggttggccgc    600

cagcttgagg agttcctgaa ccagagctcg cccttctact tctggatgaa tggtgaccgc    660

atcgactccc tgctggagaa cgaccggcag cagacgcaca tgctggatgt catgcaggac    720

cacttcagcc gcgcgtccag catcatagac gagctcttcc aggacaggtt cttcacccgg    780

gagccccagg atacctacca ctacctgccc ttcagcctgc cccaccggag gcctcacttc    840

ttctttccca agtcccgcat cgtccgcagc ttgatgccct tctctccgta cgagcccctg    900

aacttccacg ccatgttcca gcccttcctt gagatgatac acgaggctca gcaggccatg    960

gacatccact tccatagccc ggccttccag cacccgccaa cagaattcat acgagaaggc   1020

gacgatgacc ggactgtgtg ccgggagatc cgccacaact ccacgggctg cctgcggatg   1080

aaggaccagt gtgacaagtg ccgggagatc ttgtctgtgg actgttccac caacaacccc   1140

tcccaggcta agctgcggcg ggagctcgac gaatccctcc aggtcgctga gaggttgacc   1200

aggaaataca acgagctgct aaagtcctac cagtggaaga tgctcaacac ctcctccttg   1260

ctggagcagc tgaacgagca gtttaactgg gtgtcccggc tggcaaacct cacgcaaggc   1320

gaagaccagt actatctgcg ggtcaccacg gtggcttccc acacttctga ctcggacgtt   1380

ccttccggtg tcactgaggt ggtcgtgaag ctctttgact ctgatcccat cactgtgacg   1440

gtccctgtag aagtctccag gaagaaccct aaatttatgg agaccgtggc ggagaaagcg   1500

ctgcaggaat accgcaaaaa gcaccgggag gagtgagatg tggatgttgc ttttgcacct   1560

acgggggcat ctgagtccag ctccccccaa gatgagctgc agccccccag agagagctct   1620

gcacgtcacc aagtaaccag gccccagcct ccaggccccc aactccgccc agcctctccc   1680

cgctctggat cctgcactct aacactcgac tctgctgctc atgggaagaa cagaattgct   1740

cctgcatgca actaattcaa taaaactgtc ttgtgagctg atcgcttgga gggtcctctt   1800

tttatgttga gttgctgctt cccggcatgc cttcattttg ctatgggggg caggcagggg   1860

ggatggaaaa taagtagaaa caaaaaagca gtggctaaga tggtataggg actgtcatac   1920

cagtgaagaa taaaagggtg aagaataaaa gggatatgat gacaaggttg atccacttca   1980

agaattgctt gctttcagga agagagatgt gtttcaacaa gccaactaaa atatattgct   2040

gcaaatggaa gcttttctgt tctattataa aactgtcgat gtattctgac caaggtgcga   2100

caatctccta aaggaataca ctgaaagtta aggagaagaa tcagtaagtg taaggtgtac   2160

ttggtattat aatgcataat tgatgttttc gttatgaaaa catttggtgc ccagaagtcc   2220

aaattatcag ttttatttgt aagagctatt gcttttgcag cggttttatt tgtaaaagct   2280

gttgatttcg agttgtaaga gctcagcatc ccaggggcat cttcttgact gtggcatttc   2340

ctgtccaccg ccggtttata tgatcttcat acctttccct ggaccacagg cgtttctcgg   2400

cttttagtct gaaccatagc tgggctgcag taccctacgc tgccagcagg tggccatgac   2460

tacccgtggt accaatctca gtcttaaagc tcaggctttt cgttcattaa cattctctga   2520

tagaattctg gtcatcagat gtactgcaat ggaacaaaac tcatctggct gcatcccagg   2580

tgtgtagcaa agtccacatg taaatttata gcttagaata ttcttaagtc actgtccctt   2640

gtctctcttt gaagttataa acaacaaact taaagcttag cttatgtcca aggtaagtat   2700

tttagcatgg ctgtcaagga aattcagagt aaagtcagtg tgattcactt aatgatatac   2760

attaattaga attatggggt cagaggtatt tgcttaagtg atcataattg taaagtatat   2820

gtcacattgt cacattaatg tcacactgtt tcaaaagtta aaaaaaaaaa aaaaaaa      2877


<210>  44
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Control antisense oligonucleotide sequence.

<400>  44
cagcgctgac aacagtttca t                                               21


<210>  45
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Target gene expression forward primer

<400>  45
taccagctca ccaagctcct                                                 20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Target gene expression reverse primer

<400>  46
gcttcactgg gtgtggaaat                                                 20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Target gene expression forward primer

<400>  47
cacagcctgt ttcatcctga                                                 20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Target gene expression reverse primer

<400>  48
aggtccatga ccttcacagc                                                 20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Target gene expression forward primer

<400>  49
aaatctggca ccacaccttc                                                 20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Target gene expression reverse primer

<400>  50
agcactgtgt tggcgtacag                                                 20


