                         SEQUENCE LISTING

<110>  Miltenyi Biotec GmbH
 
<120>  TCRalpha/beta-depletierte Zellseparationen

<130>  MIL017WO

<150>  DE102011001380.6
<151>  2011-03-17

<150>  EP11168949.3
<151>  2011-06-07

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  2
<211>  1965
<212>  DNA
<213>  homo sapiens

<400>  2
aggcccctgc ctgccccagc atcccctgcg cgaagctggg tgccccggag agtctgacca       60

ccatgccacc tcctcgcctc ctcttcttcc tcctcttcct cacccccatg gaagtcaggc      120

ccgaggaacc tctagtggtg aaggtggaag agggagataa cgctgtgctg cagtgcctca      180

aggggacctc agatggcccc actcagcagc tgacctggtc tcgggagtcc ccgcttaaac      240

ccttcttaaa actcagcctg gggctgccag gcctgggaat ccacatgagg cccctggcca      300

tctggctttt catcttcaac gtctctcaac agatgggggg cttctacctg tgccagccgg      360

ggcccccctc tgagaaggcc tggcagcctg gctggacagt caatgtggag ggcagcgggg      420

agctgttccg gtggaatgtt tcggacctag gtggcctggg ctgtggcctg aagaacaggt      480

cctcagaggg ccccagctcc ccttccggga agctcatgag ccccaagctg tatgtgtggg      540

ccaaagaccg ccctgagatc tgggagggag agcctccgtg tctcccaccg agggacagcc      600

tgaaccagag cctcagccag gacctcacca tggcccctgg ctccacactc tggctgtcct      660

gtggggtacc ccctgactct gtgtccaggg gccccctctc ctggacccat gtgcacccca      720

aggggcctaa gtcattgctg agcctagagc tgaaggacga tcgcccggcc agagatatgt      780

gggtaatgga gacgggtctg ttgttgcccc gggccacagc tcaagacgct ggaaagtatt      840

attgtcaccg tggcaacctg accatgtcat tccacctgga gatcactgct cggccagtac      900

tatggcactg gctgctgagg actggtggct ggaaggtctc agctgtgact ttggcttatc      960

tgatcttctg cctgtgttcc cttgtgggca ttcttcatct tcaaagagcc ctggtcctga     1020

ggaggaaaag aaagcgaatg actgacccca ccaggagatt cttcaaagtg acgcctcccc     1080

caggaagcgg gccccagaac cagtacggga acgtgctgtc tctccccaca cccacctcag     1140

gcctcggacg cgcccagcgt tgggccgcag gcctgggggg cactgccccg tcttatggaa     1200

acccgagcag cgacgtccag gcggatggag ccttggggtc ccggagcccg ccgggagtgg     1260

gcccagaaga agaggaaggg gagggctatg aggaacctga cagtgaggag gactccgagt     1320

tctatgagaa cgactccaac cttgggcagg accagctctc ccaggatggc agcggctacg     1380

agaaccctga ggatgagccc ctgggtcctg aggatgaaga ctccttctcc aacgctgagt     1440

cttatgagaa cgaggatgaa gagctgaccc agccggtcgc caggacaatg gacttcctga     1500

gccctcatgg gtcagcctgg gaccccagcc gggaagcaac ctccctgggg tcccagtcct     1560

atgaggatat gagaggaatc ctgtatgcag ccccccagct ccgctccatt cggggccagc     1620

ctggacccaa tcatgaggaa gatgcagact cttatgagaa catggataat cccgatgggc     1680

cagacccagc ctggggagga gggggccgca tgggcacctg gagcaccagg tgatcctcag     1740

gtggccagcc tggatctcct caagtcccca agattcacac ctgactctga aatctgaaga     1800

cctcgagcag atgatgccaa cctctggagc aatgttgctt aggatgtgtg catgtgtgta     1860

agtgtgtgtg tgtgtgtgtg tgtgtataca tgccagtgac acttccagtc ccctttgtat     1920

tccttaaata aactcaatga gctcttccaa tcctaaaaaa aaaaa                     1965


<210>  3
<211>  7828
<212>  DNA
<213>  Homo sapiens

<400>  3
accatgcccg gctaattttt tttttttttt ttgagaagga gtctatgtgc ccagcattgt       60

tctagagcac ttgcaattag tggtgaacaa cacggtctct actccaaggg gctcacattc      120

ttgtgcagaa aacagaaatg aacaaataaa cacacaagat catttcccgt ggtagtgaga      180

gctgggatga aaataaaaca gcgtggcagg gaggaggcaa gtgttgtgag tctggagggt      240

tcctggagaa tggggcctga ggcgtgacca ccgccttcct ctctgggggg actgcctgcc      300

gcccccgcag acacccatgg ttgagtgccc tccaggcccc tgcctgcccc agcatcccct      360

gcgcgaagct gggtgccccg gagagtctga ccaccatgcc acctcctcgc ctcctcttct      420

tcctcctctt cctcaccccc atggaagtca ggcccgagga acctctagtg gtgaaggtgg      480

aaggtatgtc caaagggcag aaagggaagg gattgaggct ggaaacttga gttgtggctg      540

ggtgtccttg gctgagtaac ttaccctctc tgagcctcca ttttcttatt tgtaaaattc      600

aggaaagggt tggaaggact ctgccggctc ctccactccc agcttttgga gtcctctgct      660

ctataacctg gtgtgaggag tcggggggct tggaggtccc ccccacccat gcccacacct      720

ctctccctct ctctccacag agggagataa cgctgtgctg cagtgcctca aggggacctc      780

agatggcccc actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa      840

actcagcctg gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt      900

catcttcaac gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc      960

tgagaaggcc tggcagcctg gctggacagt caatgtggag ggcagcggtg agggccgggc     1020

tggggcaggg gcaggaggag agaagggagg ccaccatgga cagaagaggt ccgcggccac     1080

aatggagctg gagagagggg ctggagggat tgagggcgaa actcggagct aggtgggcag     1140

actcctgggg cttcgtggct tcagtatgag ctgcttcctg tccctctacc tctcactgtc     1200

ttctctctct ctgcgggtct ttgtctctat ttatctctgt ctttgagtct ctatctctct     1260

ccctctcctg ggtgtctctg catttggttc tgggtctctt cccaggggag ctgttccggt     1320

ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc tcagagggcc     1380

ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc aaagaccgcc     1440

ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg aaccagagcc     1500

tcagccaggg tatggtgatg actggggaga tgccgggaag cgggggtcca gagacagagg     1560

ggaggggaaa ctgaagaggt gaaaccctga ggatcaggct ttccttgtct tatctctccc     1620

tgtcccagac ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc     1680

tgactctgtg tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc     1740

attgctgagc ctagagctga aggacgatcg cccggccaga gatatgtggg taatggagac     1800

gggtctgttg ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg     1860

caacctgacc atgtcattcc acctggagat cactgctcgg ccaggtagag tttctctcaa     1920

ctgggaggca tctgtgtggg ggtactggga agaagtggaa gccagtcaat cttagattcc     1980

cccaacccga gggctactcc cagcctcacc ccaaacccca acttccacac agaacactga     2040

ctccaagtct ttcttttttt tgacagagtc tcgctctgtt gcctaggctg gagtgcagtg     2100

gtgccatctt gtcttggctc actgcaacct ccgcctccca ggttcaagtg attcccctgc     2160

ctcagcctcc tgagtagctg ggattacagg tgcccaccac cacgcctggc taattttttt     2220

tttttttttg agacggagtc ttgcactgtc acccaggctg gagtgcagtg gcacgatctc     2280

agctcactgc aacctccacc ttccaggttc aagtgattct cctgcctcag cctcccgagt     2340

agctgggatt aaagcctggc taattttttt tgtattttta gtagagatgg ggtttcatta     2400

tgttggccag gctggtctca aactcctgac ctcgtgatcc acccgcctcg gcctcccaaa     2460

gtgctgggat tacagacatg agccacaggg ccgggccaag cctaattttg tatttttagt     2520

agagatgggg tttctccctg ttggaccagg ctggtcttga actcctgact tcaggtgatc     2580

tgcctgcctt ggcctcccaa agtactggga ttacaggcat aagccaccgc acctggccta     2640

gacttcaagt ctttcttccc tcgcttccaa gacactactt ttctgggtct tcacctacca     2700

ttgcttgcgc ctgcccacca gcttgggtgg agtcttcctt cctccccaac tcctcactct     2760

tggagccctg ggccctcttc ttatccctgt ctgcacactt tcctatttga acttgactct     2820

caatggcttc ttgggtcacc atgccttggt gactctattc caggctccat actcagccat     2880

ctcctgtgcc atttgatatc ccatggacac ctcaggctca acagatacaa aatcaaactc     2940

aatgtcttcc ccaagtatag tcttcttggt ggcccagtgt aagcagaggg caccaccacc     3000

tgctccctcg cccaggctaa gaacctgggc atccttcttt ttcctcaccc cgtccaacaa     3060

actggtcaca gtgttctgcc aattctctct ccatgcaatc ctatcatgct atcctaactg     3120

caattcacaa acccaacccc aactttcact ccaaacttga tccaagcaat gtgctggatc     3180

ccaactgtaa ccttgcaaac tcaactctgc ccttcacttt gaccgtgact atccttaatt     3240

gcagcaggaa actgatcatt atgctcccct caatccacac attgcctctg agtacagcca     3300

tggtttgtcc acgatttgct caaagacact gccccatgtc ctgtgccagg gtctgtgaca     3360

atccctgacc tcctgggaca tggctcctta gagagaggag agcctttctc acagcttggg     3420

actttgagtc tgtgtctttt tttttttctt gagacggagt tttgctgtgg ttgcccaggc     3480

tggagtgcag tgatctcggc tcactgaaac ctccgcctcc cgggttcaaa cgattctcct     3540

gcctcagcct cccaagtagc tgggattaca ggcacccacc accatgccca gctaattttt     3600

ttgtattttt agtagagatg gggtttcacc atgttggcca ggctggtctc gaactcctga     3660

cctcaggtga tccacccgcc tttgcctccc aaagtgctgg gattacaggc gtcaaccacc     3720

gcgcccggcc gagtctgtgt cttgcctctg tgcctcagac ttgcggttcc ttgagatctc     3780

aggattggga cgtaagatgc cagcctgggg tcctcgtctc atagcccctt ccccctagta     3840

ctatggcact ggctgctgag gactggtggc tggaaggtct cagctgtgac tttggcttat     3900

ctgatcttct gcctgtgttc ccttgtgggc attcttcatc ttcaaagagg tgagtcatgt     3960

ccccagtggg tctgtccaaa ccctactcca tcttccccag gataagccgg ctctggccag     4020

tctgacaacc atctttcttt cctcccatcc ctcccttcaa gaccccagaa tcctgttctc     4080

cccagtcttc ctctagcctc cctcaaactt cccaagcctc ttgcaatttt tttttttttt     4140

ttgagacagg gtctcattct gtcaccccag ctggagtgca gtggcacaat ctgagctcac     4200

tgtaacctct gcctcccagg cttaagtgat tcttgtgctt cagcctcccg agtacctggg     4260

actacaagtg tatgccacca cacccggcca attttttata tttttagtag agacgaggtt     4320

tcaccatgtt ggccagactg gtctcgaact cttgacctca aatgatccgc ccacctcggc     4380

ctcccaaagt gctgggatta caggcacgag ccaccgcgcc cgtccgcctc gcaatttgaa     4440

ctcctgtctc ctttgttgaa ccaagtgacc tccccagcac ctggccccac aaatcctcac     4500

cctgccaagc agcccctcct ctgatcacgc cctttaactc ccaccagccc tggtcctgag     4560

gaggaaaaga aagcgaatga ctgaccccac caggaggtaa tgcaaccagt gcaccccgcg     4620

gtaacaccct ccaccttcac tttatgcctt gcacttactg tttcctctgc ccaggggttc     4680

tttgctccgt ctctactgtt tcaaatactg cccaacctca aagcccagct ccaaagctac     4740

ctcctctgtg aagaactcct tggaaatgat catctcagac tcctctattg gctgtcccag     4800

cacaagtgat cacgtttaac ttctgaaggc ctggacagaa tcttgagtgg gtccgccatt     4860

ccattccaag tcggccctca ccgtgcactt cctcttctcc cgccagattc ttcaaagtga     4920

cgcctccccc aggaagcggg ccccagaacc agtacgggaa cgtgctgtct ctccccacac     4980

ccacctcagg cctcggtaag aggcaccgcc cctccagcct atagctccgc cccagatccg     5040

gggctccacc cccactctcc tcatccctcc aatccgctgt gcgccaagcc ttctggagct     5100

cggaactccg cccccggggc ggggagtccc gcccagctat gagccccgcc tctagaacca     5160

gaccccgcct ccagggctca gagccacgcc cccaggaccc agagcctgaa gtcgtaatca     5220

agagcagaac ttcgccccag aactgaaggc ctcggcccta gatttagatt ccgccccagg     5280

gttcaaggcc gggttcctag acccagagtc cattcgcaga gcccaaaaca tcctcttccc     5340

gtgccccgcc gcgcggaccc ttagccttga ccgcccccat ctcttctgac cccgtcttac     5400

aatgcccctc tcaccaggac gcgcccagcg ttgggccgca ggcctggggg gcactgcccc     5460

gtcttatgga aacccgagca gcgacgtcca ggcggatgga gccttggggt cccggagccc     5520

gccgggagtg ggtgaatgac tgggagaggg aagggtcgtt ccccacatgg agggggttgg     5580

agcggtctgt ggcccgaata gtggactggg ccctggagga gagggggcat gactcggttc     5640

cccatcccca tccccaaacc cccaggccca gaagaagagg aaggggaggg ctatgaggaa     5700

cctgacagtg aggaggactc cgagttctat gagaacgact ccaaccttgg gcaggaccag     5760

ctctcccagg gtaaggctgc cctcccccgt ggccccccac ctctgcggtg gcctgtggac     5820

tcccatggac acccctcctt ctccaccaga tggcagcggc tacgagaacc ctgaggatga     5880

gcccctgggt cctgaggatg aagactcctt ctccaacggt aacttggggc ctttgtggga     5940

cctcagagac ttaggtgtaa ttgcagcgct gtgacactcc tagaaggggt ccctggagtt     6000

ctctctcttc tgccacagct gagtcttatg agaacgagga tgaagagctg acccagccgg     6060

tcgccaggac aatgggtgtg tgtgaggatg gcaacagtcc aggggggagg cggaggacac     6120

ctggaggcca ggaggaatag taacctccct cttccctttc cagacttcct gagccctcat     6180

gggtcagcct gggaccccag ccgggaagca acctccctgg gtgagagatg ctttcaatca     6240

gactgccttg cccagcttgg gtgacctggc ctcagctctg acaccagatc caactttgac     6300

ctgaccctga ccccaaaccc gaacccaatc ctgtgactcc tctcacctca acactgagcc     6360

ccatccccca tcctgagccc catcccccat cctgaccccc aatatttacc ccctccctaa     6420

ctgtgaatat caacaccgat cccaatgcag tatcagcctg gacttgatct ccacctcacc     6480

tcagccccag tgcagacctc aacttggacc ccagcttact ctgcagcttc ttcatgactc     6540

tgactccgac tccctccagt ttcttctttt tctttttctt ttttttgaga cggagtctcc     6600

ctctgttgcc caggctggag tgcagttgcc acctctgcct cctaggttca agcgattctc     6660

atgcctcagc ctcctgagta gctgggatta tagacgtttg ccaccacacc tggctaattt     6720

ttgtattttc agtagagaca gggtttcgcc atgttggcca gactggtctc caactcctgg     6780

cctctagtga tctgcccgcc ttggcttccc aaagtgctgg gattacaggc atgagccacc     6840

acgcccagcc cagttctgtt cttgacccct tccttagcca taatctaacc catatctaac     6900

cctgacccta cagctaactg gggccccaaa ctcaatgcta accaaatcac cccttcccag     6960

cacagcatgg gtaatgctcc tcaccttcct ctgcccctca gtcttcctcc ttaccgtagg     7020

ctgtacttcc catgccctag cctccaattc tccatccccc gcccaagcag ggtcccagtc     7080

ctatgaggat atgagaggaa tcctgtatgc agccccccag ctccgctcca ttcggggcca     7140

gcctggaccc aatcatgagg aaggtgggtg cttctgccgc tgtcccctgc tgtcccctgg     7200

gctgactttg ccttccagcc tacttccagt gccacccatg ttctcctcct ccctggtcct     7260

atccagatgc agactcttat gagaacatgg ataatcccga tgggccagac ccagcctggg     7320

gaggaggggg ccgcatgggc acctggagca ccaggtgatc ctcaggtggc caggtgagct     7380

gggactgccc ctagggaaag cggggaggga gggagatagg cacggatggc agtggctgct     7440

ggctttcagg gagggagagg gaacagggtt cctagggcct ggtgggcagg gggaggactg     7500

ctggacccct ccccatcacc gtttcttctg catagcctgg atctcctcaa gtccccaaga     7560

ttcacacctg actctgaaat ctgaagacct cgagcagatg atgccaacct ctggagcaat     7620

gttgcttagg atgtgtgcat gtgtgtaagt gtgtgtgtgt gtgtgtgtgt gtatacatgc     7680

cagtgacact tccagtcccc tttgtattcc ttaaataaac tcaatgagct cttccaatcc     7740

tatgaagtag tgccattgtg tgggaaggaa gggaaggaaa ggaaaggaag gaaagggaag     7800

ggaaggaaag gaagggaagg aaaggcgt                                        7828


<210>  4
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         


<210>  5
<211>  426
<212>  DNA
<213>  Homo sapiens

<400>  5
ccaaatatcc agaaccctga ccctgccgtg taccagctga gagactctaa atccagtgac       60

aagtctgtct gcctattcac cgattttgat tctcaaacaa atgtgtcaca aagtaaggat      120

tctgatgtgt atatcacaga caaaactgtg ctagacatga ggtctatgga cttcaagagc      180

aacagtgctg tggcctggag caacaaatct gactttgcat gtgcaaacgc cttcaacaac      240

agcattattc cagaagacac cttcttcccc agcccagaaa gttcctgtga tgtcaagctg      300

gtcgagaaaa gctttgaaac agatacgaac ctaaactttc aaaacctgtc agtgattggg      360

ttccgaatcc tcctcctgaa agtggccggg tttaatctgc tcatgacgct gcggctgtgg      420

tccagc                                                                 426


<210>  6
<211>  3430
<212>  DNA
<213>  Homo sapiens

<400>  6
ttcccgtata aagcatgaga ccgtgacttg ccagccccac agagccccgc ccttgtccat       60

cactggcatc tggactccag cctgggttgg ggcaaagagg gaaatgagat catgtcctaa      120

ccctgatcct cttgtcccac agatatccag aaccctgacc ctgccgtgta ccagctgaga      180

gactctaaat ccagtgacaa gtctgtctgc ctattcaccg attttgattc tcaaacaaat      240

gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca aaactgtgct agacatgagg      300

tctatggact tcaagagcaa cagtgctgtg gcctggagca acaaatctga ctttgcatgt      360

gcaaacgcct tcaacaacag cattattcca gaagacacct tcttccccag cccaggtaag      420

ggcagctttg gtgccttcgc aggctgtttc cttgcttcag gaatggccag gttctgccca      480

gagctctggt caatgatgtc taaaactcct ctgattggtg gtctcggcct tatccattgc      540

caccaaaacc ctctttttac taagaaacag tgagccttgt tctggcagtc cagagaatga      600

cacgggaaaa aagcagatga agagaaggtg gcaggagagg gcacgtggcc cagcctcagt      660

ctctccaact gagttcctgc ctgcctgcct ttgctcagac tgtttgcccc ttactgctct      720

tctaggcctc attctaagcc ccttctccaa gttgcctctc cttatttctc cctgtctgcc      780

aaaaaatctt tcccagctca ctaagtcagt ctcacgcagt cactcattaa cccaccaatc      840

actgattgtg ccggcacatg aatgcaccag gtgttgaagt ggaggaatta aaaagtcaga      900

tgaggggtgt gcccagagga agcaccattc tagttggggg agcccatctg tcagctggga      960

aaagtccaaa taacttcaga ttggaatgtg ttttaactca gggttgagaa aacagccacc     1020

ttcaggacaa aagtcaggga agggctctct gaagaaatgc tacttgaaga taccagccct     1080

accaagggca gggagaggac cctatagagg cctgggacag gagctcaatg agaaaggaga     1140

agagcagcag gcatgagttg aatgaaggag gcagggccgg gtcacagggc cttctaggcc     1200

atgagagggt agacagtatt ctaagtacgc cagaaagctg ttgatcggct tcaagcaggg     1260

aagggacacc taatttgctt ttcttttctt tttttttttt tttttttttt tttttttgag     1320

atggagtttt gctcttgttg cccaggctgg agtgcaatgg tgcatcttgg ctcactacaa     1380

gcctctgcct cccaggttca agtgattctc ctgcctcagc ctcccaagta gctgggatta     1440

caggcaccca ccaccatgcc cggctaattt tttgtatttt tagtagagac agggtttcac     1500

tatgttggcc aggctggtct cgaactcctg acctcaggtg atccacccgc ttcagcctcc     1560

caaagtgctg ggattacagg cgtgagccac cacacccggc ctgcttttct taaagatcaa     1620

tctgagtgct gtacggagag tgggttgtaa gccaagagta gaagcagaaa gggagcagtt     1680

gcagcagaga gatgatggag gcctgggcac ggtggtggca gggaggtaac caacaccatt     1740

caggtttcaa aggtagaacc atgcagggat gagaaagcaa agaggggatc aaggaaggca     1800

gctggatttt ggcctgagca gctgagtcaa tgatagtgcc gtttactaag aagaaaccaa     1860

ggaaaaaatt tggggtgcag ggatcaaaac tttttggaac atatgaaagt acgtgtttat     1920

actctttatg gcccttgtca ctatgtatgc ctcgctgcct cattggactc tagaatgaag     1980

ccaggcagag cagggtctat gtgtgatggc acatgtggcc agggtcatgc agacatgtac     2040

tttgtacaaa cagtgtatat tgagtaaata gaaatggtgt ccaggagccg aggtatcgtc     2100

ctgccagggc caggggctct ccctagcagg tgctcatatg ctgtaagttc cctccagatc     2160

tctccacaag gaggcatgga aaggctgtag ttgttcacct gcccaagaac taggaggtct     2220

ggggtgggag agtcagcctg ctctggatgc tgaaagaatg tctgtttttc cttttagaaa     2280

gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac aggtaagaca ggggtctagc     2340

ctgggtttgc acaggattgc cgaagtgatg aacccgcaat aaccctgcct ggatgaggga     2400

gtgggaagaa attagtagat gtgggaatga atgatgagga atggaaacag cggttcaaga     2460

cctgcccaga gctgggtggg gtctctcctg aatccctctc accgtctctg actttccgtt     2520

ctaagcactt tgaggatgag tttctagctt caatagacca aggactctct cctaggcctc     2580

tgtattcctt tcaacagctc cactgtcaag agagccagag agagcttctg ggtggcccag     2640

ctgtgaaatt tctgagtccc ttagggatag ccctaaacga accagatcat cctgaggaca     2700

gccaagaggt tttgccttct ttcaagacaa gcaacagtac tcacataggc tgtgggcaat     2760

ggtcctgtct ctcaagaatc ccctgccact cctcacaccc accctgggcc catattcatt     2820

tccatttgag ttgttcttat tgagtcatcc ttcctgtggc agcggaactc actaaggggc     2880

ccatctggac ccgaggtatt gtgaagataa attctgagca cctaccccat ccccagaagg     2940

gctcagaaat aaaataagag ccaagtctag tcggtgtttc ctgtcttgaa acacaatact     3000

gttggccctg gaagaatgca cagaatctgt ttgtaagggg atatgcacag aagctgcaag     3060

ggacaggagg tgcaggagct gcaggcctcc cccacccagc ctgctctgcc ttggggaaaa     3120

ccgtgggtgt gtcctgcagg ccatgcaggc ctgggacatg caagcccata accgctgtgg     3180

cctcttggtt ttacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga     3240

atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc     3300

tgaggtgagg ggccttgaag ctgggagtgg ggtttaggga cgcgggtctc tgcgtgcatc     3360

ctaagctctg agagcaaacc tccctgcagg gtcttgcttt taagtccaaa gcctgagccc     3420

accaaactct                                                            3430


<210>  7
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  8
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  8
gaggacctga acaaggtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag       60

atctcccaca cccaaaaggc cacactggtg tgcctggcca caggcttctt ccccgaccac      120

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtcag cacagacccg      180

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg      240

agggtctcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc      300

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc      360

gtcagcgccg aggcctgggg tagagcagac tgtggcttta cctcggtgtc ctaccagcaa      420

ggggtcctgt ctgccaccat cctctatgag atcctgctag ggaaggccac cctgtatgct      480

gtgctggtca gcgcccttgt gttgatggcc atggtcaaga gaaaggattt c               531


<210>  9
<211>  2042
<212>  DNA
<213>  Homo sapiens

<400>  9
tgcatcctag ggacagcata gaaaggaggg gcaaagtgga gagagagcaa cagacactgg       60

gatggtgacc ccaaaacaat gagggcctag aatgacatag ttgtgcttca ttacggccca      120

ttcccagggc tctctctcac acacacagag cccctaccag aaccagacag ctctcagagc      180

aaccctggct ccaacccctc ttccctttcc agaggacctg aacaaggtgt tcccacccga      240

ggtcgctgtg tttgagccat cagaagcaga gatctcccac acccaaaagg ccacactggt      300

gtgcctggcc acaggcttct tccccgacca cgtggagctg agctggtggg tgaatgggaa      360

ggaggtgcac agtggggtca gcacggaccc gcagcccctc aaggagcagc ccgccctcaa      420

tgactccaga tactgcctga gcagccgcct gagggtctcg gccaccttct ggcagaaccc      480

ccgcaaccac ttccgctgtc aagtccagtt ctacgggctc tcggagaatg acgagtggac      540

ccaggatagg gccaaacccg tcacccagat cgtcagcgcc gaggcctggg gtagagcagg      600

tgagtggggc ctggggagat gcctggagga gattaggtga gaccagctac cagggaaaat      660

ggaaagatcc aggtagcaga caagactaga tccaaaaaga aaggaaccag cgcacaccat      720

gaaggagaat tgggcacctg tggttcattc ttctcccaga ttctcagccc aacagagcca      780

agcagctggg tcccctttct atgtggcctg tgtaactctc atctgggtgg tgccccccat      840

ccccctcagt gctgccacat gccatggatt gcaaggacaa tgtggctgac atctgcatgg      900

cagaagaaag gaggtgctgg gctgtcagag gaagctggtc tgggcctggg agtctgtgcc      960

aactgcaaat ctgactttac ttttaattgc ctatgaaaat aaggtctctc atttattttc     1020

ctctccctgc tttctttcag actgtggctt tacctcgggt aagtaagccc ttccttttcc     1080

tctccctctc tcatggttct tgacctagaa ccaaggcatg aagaactcac agacactgga     1140

gggtggaggg tgggagagac cagagctacc tgtgcacagg tacccacctg tccttcctcc     1200

gtgccaacag tgtcctacca gcaaggggtc ctgtctgcca ccatcctcta tgagatcctg     1260

ctagggaagg ccaccctgta tgctgtgctg gtcagcgccc ttgtgttgat ggccatggta     1320

agcaggaggg caggatgggg ccagcaggct ggaggtgaca cactgacacc aagcacccag     1380

aagtatagag tccctgccag gattggagct gggcagtagg gagggaagag atttcattca     1440

ggtgcctcag aagataactt gcacctctgt aggatcacag tggaagggtc atgctgggaa     1500

ggagaagctg gagtcaccag aaaacccaat ggatgttgtg atgagcctta ctatttgtgt     1560

ggtcaatggg ccctactact ttctctcaat cctcacaact cctggctctt aataaccccc     1620

aaaactttct cttctgcagg tcaagagaaa ggatttctga aggcagccct ggaagtggag     1680

ttaggagctt ctaacccgtc atggtttcaa tacacattct tcttttgcca gcgcttctga     1740

agagctgctc tcacctctct gcatcccaat agatatcccc ctatgtgcat gcacacctgc     1800

acactcacgg ctgaaatctc cctaacccag ggggacctta gcatgcctaa gtgactaaac     1860

caataaaaat gttctggtct ggcctgactc tgacttgtga atgtctggat agctccttgg     1920

ctgtctctga actccctgtg actctcccca ttcagtcagg atagaaacaa gaggtattca     1980

aggaaaatgc agactcttca cgtaagaggg atgaggggcc caccttgaga tcaatagcag     2040

aa                                                                    2042


<210>  10
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Ser Arg Gly 
            


<210>  11
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
                165                 170                 175     


Arg Gly 
        


<210>  12
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  12
gaggacctga aaaacgtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag       60

atctcccaca cccaaaaggc cacactggtg tgcctggcca caggcttcta ccccgaccac      120

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtcag cacagacccg      180

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg      240

agggtctcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc      300

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacctgt cacccagatc      360

gtcagcgccg aggcctgggg tagagcagac tgtggcttca cctccgagtc ttaccagcaa      420

ggggtcctgt ctgccaccat cctctatgag atcttgctag ggaaggccac cttgtatgcc      480

gtgctggtca gtgccctcgt gctgatggcc atggtcaaga gaaaggattc cagaggc         537


<210>  13
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  13
gacctgaaaa acgtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc       60

tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttctaccc cgaccacgtg      120

gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtcagcac agacccgcag      180

cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg      240

gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac      300

gggctctcgg agaatgacga gtggacccag gatagggcca aacctgtcac ccagatcgtc      360

agcgccgagg cctggggtag agcagactgt ggcttcacct ccgagtctta ccagcaaggg      420

gtcctgtctg ccaccatcct ctatgagatc ttgctaggga aggccacctt gtatgccgtg      480

ctggtcagtg ccctcgtgct gatggccatg gtcaagagaa aggattccag aggc            534


<210>  14
<211>  2008
<212>  DNA
<213>  Homo sapiens

<400>  14
atggcgtagt ccccaaagaa cgaggaccta gtaacataat tgtgcttcat tatggtcctt       60

tcccggcctt ctctctcaca catacacaga gcccctacca ggaccagaca gctctcagag      120

caaccctagc cccattacct cttccctttc cagaggacct gaaaaacgtg ttcccacccg      180

aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag gccacactgg      240

tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg gtgaatggga      300

aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag cccgccctca      360

atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc tggcagaacc      420

cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat gacgagtgga      480

cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg ggtagagcag      540

gtgagtgggg cctggggaga tgcctggagg agattaggtg agaccagcta ccagggaaaa      600

tggaaagatc caggtagcgg acaagactag atccagaaga aagccagagt ggacaaggtg      660

ggatgatcaa ggttcacagg gtcagcaaag cacggtgtgc acttccccca ccaagaagca      720

tagaggctga atggagcacc tcaagctcat tcttccttca gatcctgaca ccttagagct      780

aagctttcaa gtctccctga ggaccagcca tacagctcag catctgagtg gtgtgcatcc      840

cattctcttc tggggtcctg gtttcctaag atcatagtga ccacttcgct ggcactggag      900

cagcatgagg gagacagaac cagggctatc aaaggaggct gactttgtac tatctgatat      960

gcatgtgttt gtggcctgtg agtctgtgat gtaaggctca atgtccttac aaagcagcat     1020

tctctcatcc atttttcttc ccctgttttc tttcagactg tggcttcacc tccggtaagt     1080

gagtctctcc tttttctctc tatctttcgc cgtctctgct ctcgaaccag ggcatggaga     1140

atccacggac acaggggcgt gagggaggcc agagccacct gtgcacaggt acctacatgc     1200

tctgttcttg tcaacagagt cttaccagca aggggtcctg tctgccacca tcctctatga     1260

gatcttgcta gggaaggcca ccttgtatgc cgtgctggtc agtgccctcg tgctgatggc     1320

catggtaagg aggagggtgg gatagggcag atgatggggg caggggatgg aacatcacac     1380

atgggcataa aggaatctca gagccagagc acagcctaat atatcctatc acctcaatga     1440

aaccataatg aagccagact ggggagaaaa tgcagggaat atcacagaat gcatcatggg     1500

aggatggaga caaccagcga gccctactca aattaggcct cagagcccgc ctcccctgcc     1560

ctactcctgc tgtgccatag cccctgaaac cctgaaaatg ttctctcttc cacaggtcaa     1620

gagaaaggat tccagaggct agctccaaaa ccatcccagg tcattcttca tcctcaccca     1680

ggattctcct gtacctgctc ccaatctgtg ttcctaaaag tgattctcac tctgcttctc     1740

atctcctact tacatgaata cttctctctt ttttctgttt ccctgaagat tgagctccca     1800

acccccaagt acgaaatagg ctaaaccaat aaaaaattgt gtgttgggcc tggttgcatt     1860

tcaggagtgt ctgtggagtt ctgctcatca ctgacctatc ttctgattta gggaaagcag     1920

cattcgcttg gacatctgaa gtgacagccc tctttctctc cacccaatgc tgctttctcc     1980

tgttcatcct gatggaagtc tcaacaca                                        2008


