                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  METHOD, PROBE AND KIT FOR DNA IN SITU HYBRIDATION AND USE THEREOF

<130>  B9349_AD/AFL/CAL

<140>  Unkown
<141>  2012-03-16

<150>  EP 11290139.2
<151>  2011-03-17

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(99)
<223>  Sequence name: mREP sequence (HSmREP or HS), coordinates 446-544 
       on the sequence of the human mitochondrial genome (accession 
       number NC_012920.1, NCBI, GenBank or MITOMAP)

<220>
<221>  misc_feature
<222>  (1)..(99)
<223>  Polymorphism(s), e.g. nucleotide(s) substitution(s), may be 
       observed on positions 2, 5, 8, 10-11, 13-17, 19, 21, 23-24, 26, 
       30, 32, 35-37, 40, 42, 44-46, 48-50, 52-54, 56-57, 62-63, 66-80, 
       82-83, 85, 88-90, 93, 96-97, 99

<400>  1
acattatttt cccctcccac tcccatacta ctaatctcat caatacaacc cccgcccatc       60

ctacccagca cacacacacc gctgctaacc ccatacccc                              99


<210>  2
<211>  98
<212>  DNA
<213>  Pan troglodytes


<220>
<221>  misc_feature
<222>  (1)..(98)
<223>  Sequence name: Pt, coordinates 16424-16521 on the sequence 
       Nc_001643.1 (NCBI or GenBank accession number)

<400>  2
acatgccctc ccccctcaac tcccattcta ctagccccag caacgtaacc ccctactcac       60

cctactcaac acatataccg ctgctaaccc cataccct                               98


<210>  3
<211>  98
<212>  DNA
<213>  Pan paniscus


<220>
<221>  misc_feature
<222>  (1)..(98)
<223>  sequence name: Panp, coordinates 16433-16530 on the sequence 
       NC_001644.1 (NCBI or GenBank accession number)

<400>  3
acatgtcctc ccccctcaac tcccattcca ctagccccaa caacataacc ccctgcccac       60

cccactcagc acatataccg ctgctaaccc tataccct                               98


<210>  4
<211>  100
<212>  DNA
<213>  Gorilla gorilla


<220>
<221>  misc_feature
<222>  (1)..(100)
<223>  name: Grg, coordinates 16233-16332 on the sequence NC_001645.1 
       (NCBI or GenBank accession number)

<400>  4
gtatgcactt ttaacagtca cccctcaact aacatagtca gcccaccagt acaacccccg       60

cccgccctag caacacacac tgctgctgat cctatacccc                            100


<210>  5
<211>  111
<212>  DNA
<213>  Pongo pygmaeus


<220>
<221>  misc_feature
<222>  (1)..(111)
<223>  sequence name: Pp, coordinates 16247-16357 on the sequence 
       NC_001646.1 (NCBI or GenBank accession number)

<400>  5
atgtgcactt tcaacaggca cccctcaact aacacaaccc acttttaatt tccacctacc       60

aacccatcct gccctgcctt cccacaaaca ccactactac ccccacacct c               111


<210>  6
<211>  99
<212>  DNA
<213>  Hybolates lar


<220>
<221>  misc_feature
<222>  (1)..(99)
<223>  sequence name: H1, coordinates 16148-16246 on the sequence 
       NC_002082.1 (NCBI or GenBank accession number)

<400>  6
acattccata ttccagccga gcatccaatc cactaaaggt gctaattaat tcatgcttgt       60

tggacatagc aataaccaac caacgtaacc ccaaaccac                              99


<210>  7
<211>  99
<212>  DNA
<213>  Cebus albifrons


<220>
<221>  misc_feature
<222>  (1)..(99)
<223>  sequence name: Ca, coordinates 15946-16044 on the sequence 
       NC_002763.1 (NCBI or GenBank accession number)

<400>  7
gcatttggtt cctacctcag ggccatctca ctaagaccgt gtccacgttc ctcttaaata       60

agacatcacg atggtgtggc gctatcaccc tcttaaccg                              99


<210>  8
<211>  112
<212>  DNA
<213>  Capra hircus


<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  sequence name: Ch, coordinates 15519-15630 on the sequence 
       NC_005044.2 (NCBI or Genbank accession number)

<400>  8
acacaaactt cccactccac aagcttacag acatgccaac aacccacacg tataaaaaca       60

tcccaatcct aacccaactt agatacccac acaaacgcca acaccacaca at              112


<210>  9
<211>  104
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(104)
<223>  sequence name: Mm, coordinates 15654-15757 on the sequence 
       NC_005089.1 (NCBI or GenBank accession number)

<400>  9
atatgactat ccccttcccc atttggtcta ttaatctacc atcctccgtg aaaccaacaa       60

cccgcccacc aatgcccctc ttctcgctcc gggcccatta aact                       104


<210>  10
<211>  101
<212>  DNA
<213>  Oryctolagus cuniculus


<220>
<221>  misc_feature
<222>  (1)..(101)
<223>  sequence name: Oc, coordinates 15767-15867 on the sequence 
       NC_001913.1 (NCBI or GenBank accession number)

<400>  10
agaccatcaa atctacacac accactcaac tcttacccat acgactatcc ctctccccca       60

gtcctctcac aacttaccat cctccgtgaa accaacaacc c                          101


<210>  11
<211>  100
<212>  DNA
<213>  Canis lupus


<220>
<221>  misc_feature
<222>  (1)..(100)
<223>  sequence name Cl, coordinates 16456-16555 ono the sequence 
       NC_008092.1 (NCBI or GenBank accession number)

<400>  11
acttatacaa acccccctta ccccccgtaa actcatgtca tctattatac acttatttat       60

gtcccgccaa accccaaaaa caggactaag tgcatacaat                            100


<210>  12
<211>  102
<212>  DNA
<213>  Rattus sordidus


<220>
<221>  misc_feature
<222>  (1)..(102)
<223>  Sequence name: Rs, coordinates 15643-15744 on the sequence 
       NC_014871.1 (NCBI or GenBank accession number)

<400>  12
tcataaacct ttctcttcca tatgactatc cctgacccca attggtctat atttctacca       60

tcctccgtga aatcaacaac ccgcccacta gtccccctct cc                         102


<210>  13
<211>  106
<212>  DNA
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(106)
<223>  Sequence name: Fc, coordinates 759-864 on the sequence 
       NC_001700.1 (NCBI or GenBank accession number)

<400>  13
atactaaatc ataactctgt tcgcagttat ctatagatat accgacctga ctctaattcg       60

tccctatcga acaacatttt acatgtctac gttagcccca catccc                     106


<210>  14
<211>  102
<212>  DNA
<213>  Castor canadensis


<220>
<221>  misc_feature
<222>  (1)..(102)
<223>  Sequence name Cc, coordinates 15766-15866 on the sequence 
       NC_015108.1 (NCBI or GenBank accession number)

<400>  14
acagtctctt aatctaccat cctccgtgaa accagcaacc cgctcgggga atgtcccctc       60

ttctcgctcc gggcccatac aacttggggg tttctattct ga                         102


<210>  15
<211>  100
<212>  DNA
<213>  Gallus gallus


<220>
<221>  misc_feature
<222>  (1)..(100)
<223>  Sequence name: Gg, coordinates 473-571 on the sequence 
       NC_001323.1 (NCBI or GenBank accession number)

<400>  15
ccattctttc cccctacacc cctcgcccta cttgccttcc accgtacctc tggttcctcg       60

gtcaggcaca tcccatgcat aactcctgaa ctttctcact                            100


<210>  16
<211>  99
<212>  DNA
<213>  Danio rerio


<220>
<221>  misc_feature
<222>  (1)..(99)
<223>  Sequence name: Dr, coordinates 682-782 on the sequence 
       NC_002333.2 (NCBI or GenBank accession number)

<400>  16
actatatatt attatctccc ccttttggta tacgcgcgac aaaccccctt acccccttac       60

gtccagcgat tcctgttatc cttgtcaaac ccctaaacc                              99


<210>  17
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(201)
<223>  sequence of the PL-OH probe (position 225-425) according to the 
       reference human mitochondrial sequence NC_012920, GenBank

<400>  17
gtaggacata ataataacaa ttgaatgtct gcacagccac tttccacaca gacatcataa       60

caaaaaattt ccaccaaacc ccccctcccc cgcttctggc cacagcactt aaacacatct      120

ctgccaaacc ccaaaaacaa agaaccctaa caccagccta accagatttc aaattttatc      180

ttttggcggt atgcactttt a                                                201


<210>  18
<211>  202
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(202)
<223>  sequence of the 7S probe (position 16366-16566) according to the 
       reference human mitochondrial sequence NC_012920, GenBank

<400>  18
catggatgac ccccctcaga taggggtccc ttgaccacca tcctccgtga aatcaatatc       60

ccgcacaaga gtgctactct cctcgctccg ggcccataac acttgggggt agctaaagtg      120

aactgtatcc gacatctggt tcctacttca gggtcataaa gcctaaatag cccacacgtt      180

ccccttaaat aagacatcac ga                                               202


<210>  19
<211>  991
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(991)
<223>  mt DNA fragment between coordinates 16024 and 445 of the circular
       human mt gDNA: concatenation of fragment 16024 -16568 and 
       fragment 1-445 H strand numerotation), from Genbank sequence 
       reference NC_012920.1

<220>
<221>  misc_feature
<222>  (546)..(546)
<223>  position 16568

<220>
<221>  misc_feature
<222>  (547)..(547)
<223>  position 1

<400>  19
ttctttcatg gggaagcaga tttgggtacc acccaagtat tgactcaccc atcaacaacc       60

gctatgtatt tcgtacatta ctgccagcca ccatgaatat tgtacggtac cataaatact      120

tgaccacctg tagtacataa aaacccaatc cacatcaaaa ccccctcccc atgcttacaa      180

gcaagtacag caatcaaccc tcaactatca cacatcaact gcaactccaa agccacccct      240

cacccactag gataccaaca aacctaccca cccttaacag tacatagtac ataaagccat      300

ttaccgtaca tagcacatta cagtcaaatc ccttctcgtc cccatggatg acccccctca      360

gataggggtc ccttgaccac catcctccgt gaaatcaata tcccgcacaa gagtgctact      420

ctcctcgctc cgggcccata acacttgggg gtagctaaag tgaactgtat ccgacatctg      480

gttcctactt cagggtcata aagcctaaat agcccacacg ttccccttaa ataagacatc      540

acgatggatc acaggtctat caccctatta accactcacg ggagctctcc atgcatttgg      600

tattttcgtc tggggggtat gcacgcgata gcattgcgag acgctggagc cggagcaccc      660

tatgtcgcag tatctgtctt tgattcctgc ctcatcctat tatttatcgc acctacgttc      720

aatattacag gcgaacatac ttactaaagt gtgttaatta attaatgctt gtaggacata      780

ataataacaa ttgaatgtct gcacagccac tttccacaca gacatcataa caaaaaattt      840

ccaccaaacc ccccctcccc cgcttctggc cacagcactt aaacacatct ctgccaaacc      900

ccaaaaacaa agaaccctaa caccagccta accagatttc aaattttatc ttttggcggt      960

atgcactttt aacagtcacc ccccaactaa c                                     991


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe TBP

<400>  20
ctcacaggtc aaaggtttac                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe TBP

<400>  21
gctgaggttg caggaattga                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe 12S (1)

<400>  22
ctgctcgcca gaacactacg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe 12S (1)

<400>  23
tgagcaagag gtggtgaggt                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe 12S (2)

<400>  24
aaactgctcg ccagaacact                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe 12S (2)

<400>  25
catgggctac accttgacct                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe 16S (1)

<400>  26
gtatgaatgg ctccacgagg                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe 16S (1)

<400>  27
ggtcttctcg tcttgctgtg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe 16S (2)

<400>  28
gctaaaccta gccccaaacc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe 16S (2)

<400>  29
ttggctctcc ttgcaaagtt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ND1

<400>  30
tggccaacct cctactcctc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe  ND1

<400>  31
atggcgtcag cgaagggttg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ND2

<400>  32
actgcgctaa gctcgcactg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ND2

<400>  33
attatggatg cggttgcttg                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe COI

<400>  34
accctagacc aaacctacgc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe COI

<400>  35
taggccgaga aagtgttgtg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe COII

<400>  36
acagatgcaa ttcccggacg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe COII

<400>  37
ggcatgaaac tgtggtttgc                                                   20


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ATP8

<400>  38
atgccccaac taaatact                                                     18


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ATP8

<400>  39
ttgtgggggc aatgaatg                                                     18


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ATP6

<400>  40
cccacttctt accacaaggc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ATP6

<400>  41
gtaggtggcc tgcagtaatg                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe COIII

<400>  42
acttccactc cataacgctc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe COIII

<400>  43
tggccttggt atgtgctttc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ND3

<400>  44
ctaccatgag ccctacaaac                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ND3

<400>  45
actcataggc cagacttagg                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ND4L

<400>  46
tatcgctcac acctcatatc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ND4L

<400>  47
aggcggcaaa gactagtatg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ND4

<400>  48
acaagctcca tctgcctacg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ND4

<400>  49
ttatgagaat gactgcgccg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ND5

<400>  50
ggtttcatcc tcgccttagc                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ND5

<400>  51
acctaattgg gctgatttgc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe CYTB

<400>  52
ctcccgtgag gccaaatatc                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe CYTB

<400>  53
gaatcgtgtg agggtgggac                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe ND6

<400>  54
attggtgctg tgggtgaaag                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe ND6

<400>  55
ggatcctccc gaatcaaccc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe NRF1

<400>  56
ggagtgatgt ccgcacagaa                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe NRF1

<400>  57
cgctgttaag cgccatagtg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe POLG

<400>  58
gagaaggccc agcagatgta                                                   20


<210>  59
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe POLG

<400>  59
atccgacagc cgatacca                                                     18


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe TFAM

<400>  60
gacttctgcc agcataatac                                                   20


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe TFAM

<400>  61
gagttctgcc tgctttatg                                                    19


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe 18S

<400>  62
gagaaacggc taccacatcc                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe 18S

<400>  63
gcctcgaaag agtcctgtat                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe 12S

<400>  64
gctcgccaga acactacgag                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer  - probe 12S

<400>  65
cagggtttgc tgaagatggc                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer - probe A

<400>  66
gtggctttgg agttgcagtt                                                   20


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe B1

<400>  67
cagccaccat gaatattgta c                                                 21


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer - probe B2

<400>  68
gaagcagatt tgggtaccac                                                   20


