
                                SEQUENCE LISTING

<110> Omeros Corporation
      Leppard, John Benjamin
      Wood, Christi L.
      Cummings, W. Jason
      Yabuki, Munehisa
      Maizels, Nancy
      Allison, Daniel S.
      Tjoelker, Larry W.

<120> GENERATION OF ANTI-FN14 MONOCLONAL
  ANTIBODIES BY EX-VIVO ACCELERATED ANTIBODY EVOLUTION
  

<130> 980087.403PC

<140> PCT                  
<141> 2012-03-09

<150> US 61/512,236
<151> 2011-07-27

<150> US 61/451,477
<151> 2011-03-10

<160> 94

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 124
<212> PRT
<213> Gallus gallus

<400> 1
Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala
 1               5                  10                  15      
Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Asn Ala
            20                  25                  30          
Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
        35                  40                  45              
Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val Lys
    50                  55                  60                  
Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg Leu
65                  70                  75                  80  
Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Thr
                85                  90                  95      
Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp
            100                 105                 110         
Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 


<210> 2
<211> 124
<212> PRT
<213> Gallus gallus

<400> 2
Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala
 1               5                  10                  15      
Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp
            20                  25                  30          
Met Ala Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val Ala
        35                  40                  45              
Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
    50                  55                  60                  
Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg Leu
65                  70                  75                  80  
Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Thr
                85                  90                  95      
Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp
            100                 105                 110         
Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 


<210> 3
<211> 124
<212> PRT
<213> Gallus gallus

<400> 3
Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala
 1               5                  10                  15      
Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp
            20                  25                  30          
Met Ala Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val Ala
        35                  40                  45              
Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
    50                  55                  60                  
Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg Leu
65                  70                  75                  80  
Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Thr
                85                  90                  95      
Lys Cys Ala Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp
            100                 105                 110         
Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 


<210> 4
<211> 124
<212> PRT
<213> Gallus gallus

<400> 4
Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala
 1               5                  10                  15      
Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp
            20                  25                  30          
Met Ala Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val Ala
        35                  40                  45              
Gly Ile Asp Tyr Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
    50                  55                  60                  
Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg Leu
65                  70                  75                  80  
Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Thr
                85                  90                  95      
Lys Cys Gly Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp
            100                 105                 110         
Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 


<210> 5
<211> 124
<212> PRT
<213> Gallus gallus

<400> 5
Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly Ala
 1               5                  10                  15      
Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp
            20                  25                  30          
Met Phe Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val Ala
        35                  40                  45              
Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
    50                  55                  60                  
Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg Leu
65                  70                  75                  80  
Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys Thr
                85                  90                  95      
Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp
            100                 105                 110         
Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 


<210> 6
<211> 372
<212> DNA
<213> Gallus gallus

<400> 6
gtgacgttgg acgagtccgg gggcggcctc cagacgcccg ggggagcgct cagcctcgtc 60
tgcaaggcct ccgggttcac cttcagcagt aacgccatgg gttgggtgcg acaggcgccc 120
ggcaaggggc tggagtgggt cgctggtatt gatgatgatg gtagtggcac aagatacgcg 180
ccggcggtga agggccgtgc caccatctcg agggacaacg ggcagagcac actgaggctg 240
cagctgaaca acctcagggc tgaggacacc ggcacctact actgcacgaa atgtgcttac 300
agtagtggtt gtgattatga aggtggttat atcgacgcat ggggccacgg gaccgaagtc 360
atcgtctcct cc                                                     372

<210> 7
<211> 372
<212> DNA
<213> Gallus gallus

<400> 7
gtgacgttgg acgagtccgg gggcggcctc cagacgcccg ggggagcgct cagcctcgtc 60
tgcaaggcct ccgggttcac cttcagcagt tacgacatgg cctgggtgcg acaggagccc 120
ggcaaggggc tggagtgggt cgctggtatt gatgatgatg gtagtggcag aagatacgcg 180
ccggcggtga agggccgtgc caccatctcg agggacaacg ggcagagcac actgaggctg 240
cagctgaaca acctcagggc tgaggacacc ggcacctatt actgcacgaa atgtgcttac 300
agtagtggtt gtgattatga aggtggttat atcgacgcat ggggccacgg gaccgaagtc 360
atcgtctcct cc                                                     372

<210> 8
<211> 372
<212> DNA
<213> Gallus gallus

<400> 8
gtgacgttgg acgagtccgg gggcggcctc cagacgcccg ggggagcgct cagcctcgtc 60
tgcaaggcct ccgggttcac cttcagcagt tacgacatgg cctgggtgcg acaggagccc 120
ggcaaggggc tggagtgggt cgctggtatt gatgatgatg gtagtggcag aagatacgcg 180
ccggcggtga agggccgtgc caccatctcg agggacaacg ggcagagcac actgaggctg 240
cagctgaaca acctcagggc tgaggacacc ggcacctatt actgcacgaa atgtgcttac 300
actggtggtt gtgattatga aggtggttat atcgacgcat ggggccacgg gaccgaagtc 360
atcgtctcct cc                                                     372

<210> 9
<211> 372
<212> DNA
<213> Gallus gallus

<400> 9
gtgacgttgg acgagtccgg gggcggcctc cagacgcccg ggggagcgct cagcctcgtc 60
tgcaaggcct ccgggttcac cttcagcagt tacgacatgg cctgggtgcg acaggagccc 120
ggcaaggggc tggagtgggt cgctggtatt gattatgatg gtagtggcag aagatacgcg 180
ccggcggtga agggccgtgc caccatctcg agggacaacg ggcagagcac actgaggctg 240
cagctgaaca acctcagggc tgaggacacc ggcacctatt actgcacgaa atgtggttac 300
actggtggtt gtgattatga aggtggttat atcgacgcat ggggccacgg gaccgaagtc 360
atcgtctcct cc                                                     372

<210> 10
<211> 372
<212> DNA
<213> Gallus gallus

<400> 10
gtgacgttgg acgagtccgg gggcggcctc cagacgcccg ggggagcgct cagcctcgtc 60
tgcaaggcct ccgggttcac cttcagcagt tacgacatgt tctgggtgcg acaggagccc 120
ggcaaggggc tggagtgggt cgctggtatt gatgatgatg gtagtggcag aagatacgcg 180
ccggcggtga agggccgtgc caccatctcg agggacaacg ggcagagcac actgaggctg 240
cagctgaaca acctcagggc tgaggacacc ggcacctatt actgcacgaa atgtgcttac 300
agtagtggtt gtgattatga aggtggttat atcgacgcat ggggccacgg gaccgaagtc 360
atcgtctcct cc                                                     372

<210> 11
<211> 6
<212> PRT
<213> Gallus gallus

<400> 11
Ser Ser Asn Ala Met Gly
 1               5      


<210> 12
<211> 16
<212> PRT
<213> Gallus gallus

<400> 12
Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val Lys
 1               5                  10                  15      


<210> 13
<211> 15
<212> PRT
<213> Gallus gallus

<400> 13
Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr
 1               5                  10                  15  


<210> 14
<211> 6
<212> PRT
<213> Gallus gallus

<400> 14
Ser Ser Tyr Asp Met Phe
 1               5      


<210> 15
<211> 11
<212> PRT
<213> Gallus gallus

<400> 15
Ser Ser Tyr Asp Met Phe Trp Val Arg Gln Glu
 1               5                  10      


<210> 16
<211> 6
<212> PRT
<213> Gallus gallus

<400> 16
Ser Ser Tyr Asp Met Ala
 1               5      


<210> 17
<211> 11
<212> PRT
<213> Gallus gallus

<400> 17
Ser Ser Tyr Asp Met Ala Trp Val Arg Gln Glu
 1               5                  10      


<210> 18
<211> 16
<212> PRT
<213> Gallus gallus

<400> 18
Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
 1               5                  10                  15      


<210> 19
<211> 16
<212> PRT
<213> Gallus gallus

<400> 19
Gly Ile Asp Tyr Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
 1               5                  10                  15      


<210> 20
<211> 15
<212> PRT
<213> Gallus gallus

<400> 20
Thr Lys Cys Ala Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr
 1               5                  10                  15  


<210> 21
<211> 15
<212> PRT
<213> Gallus gallus

<400> 21
Thr Lys Cys Gly Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr
 1               5                  10                  15  


<210> 22
<211> 107
<212> PRT
<213> Gallus gallus

<400> 22
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Leu Gly Gly Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr
            20                  25                  30          
Gly Trp Tyr Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile
        35                  40                  45              
Tyr Asp Asn Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala
65                  70                  75                  80  
Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala
                85                  90                  95      
Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105         


<210> 23
<211> 109
<212> PRT
<213> Gallus gallus

<400> 23
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Leu Val Thr
        35                  40                  45              
Leu Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val
65                  70                  75                  80  
Arg Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser
                85                  90                  95      
Gly Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105                 


<210> 24
<211> 109
<212> PRT
<213> Gallus gallus

<400> 24
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr
        35                  40                  45              
Leu Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val
65                  70                  75                  80  
Arg Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ile Asp Asn Ser
                85                  90                  95      
Gly Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105                 


<210> 25
<211> 109
<212> PRT
<213> Gallus gallus

<400> 25
Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr
        35                  40                  45              
Leu Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val
65                  70                  75                  80  
Arg Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ile Asp Asn Ser
                85                  90                  95      
Gly Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105                 


<210> 26
<211> 109
<212> PRT
<213> Gallus gallus

<400> 26
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr
        35                  40                  45              
Val Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val
65                  70                  75                  80  
Arg Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ile Asp Asn Ser
                85                  90                  95      
Gly Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105                 


<210> 27
<211> 109
<212> PRT
<213> Gallus gallus

<400> 27
Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr
        35                  40                  45              
Leu Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val
65                  70                  75                  80  
Arg Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ile Asp Asn Ser
                85                  90                  95      
Gly Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105                 


<210> 28
<211> 322
<212> DNA
<213> Gallus gallus

<400> 28
gcgctgactc agccggcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc 60
tccgggggtg gcagctatgc tggaagttac tattatggct ggtaccagca gaagtctcct 120
ggcagtgccc ctgtcactgt gatctatgac aacgacaaga gaccctcgga catcccttca 180
cgattctccg gttccctatc cggctccaca aacacattaa ccatcactgg ggtccgagcc 240
gatgacgagg ctgtctattt ctgtgggagt gcagacaaca gtggtgctgc atttggggcc 300
gggacaaccc tgaccgtcct ag                                          322

<210> 29
<211> 328
<212> DNA
<213> Gallus gallus

<400> 29
gcgctgactc agccggcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccgggggtg gtagcagcta ctatgctgga agttactatt atggctggta ccagcagaag 120
gcacctggca gtgcccttgt cactctgatc tattacaaca acaagagacc ctcggacatc 180
ccttcacgat tctccggttc cctatccggc tccacaaaca cattaaccat cactggggtc 240
cgagccgatg acgaggctgt ctatttctgt gggagtgcag acaacagtgg tgctgcattt 300
ggggccggga caaccctgac cgtcctag                                    328

<210> 30
<211> 328
<212> DNA
<213> Gallus gallus

<400> 30
gcgctgactc agccggcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccgggggtg gtagcagcta ctatgctgga agttactatt atggctggta ccagcagaag 120
gcacctggca gtgcccctgt cactctgatc tattacaaca acaagagacc ctcggacatc 180
ccttcacgat tctccggttc cctatccggc tccacaaaca cattaaccat cactggggtc 240
cgagccgatg acgaggctgt ctatttctgt gggagcatag acaacagtgg tgctgcattt 300
ggggccggga caaccctgac cgtcctag                                    328

<210> 31
<211> 328
<212> DNA
<213> Gallus gallus

<400> 31
gcgctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccgggggtg gtagcagcta ctatgctgga agttactatt atggctggta ccagcagaag 120
gcacctggca gtgcccctgt cactctgatc tattacaaca acaagagacc ctcggacatc 180
ccttcacgat tctccggttc cctatccggc tccacaaaca cattaaccat cactggggtc 240
cgagccgatg acgaggctgt ctatttctgt gggagcatag acaacagtgg tgctgcattt 300
ggggccggga caaccctgac cgtcctag                                    328

<210> 32
<211> 328
<212> DNA
<213> Gallus gallus

<400> 32
gcgctgactc agccggcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccgggggtg gtagcagcta ctatgctgga agttactatt atggctggta tcagcagaag 120
tcacctggca gtgcccctgt cactgtgatc tattacaaca acaagagacc ctcggacatc 180
ccttcacgat tctccggttc cctatccggc tccacaaaca cattaaccat cactggggtc 240
cgagccgatg acgaggctgt ctatttctgt gggagcatag acaacagtgg tgctgcattt 300
ggggccggga caaccctgac cgtcctag                                    328

<210> 33
<211> 328
<212> DNA
<213> Gallus gallus

<400> 33
gcgctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccgggggtg gtagcagcta ctatgctgga agttactatt atggctggta ccagcagaag 120
gcacctggca gtgcccctgt cactctgatc tattacaaca acaagagacc ctcggacatc 180
ccttcacgat tctccggttc cctatccggc tccacaaaca cattaaccat cactggggtc 240
cgagccgatg acgaggctgt ctatttctgt gggagcatag acaacagtgg tgctgcattt 300
ggggccggga caaccctgac cgtcctag                                    328

<210> 34
<211> 12
<212> PRT
<213> Gallus gallus

<400> 34
Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr Gly
 1               5                  10          


<210> 35
<211> 7
<212> PRT
<213> Gallus gallus

<400> 35
Asp Asn Asp Lys Arg Pro Ser
 1               5          


<210> 36
<211> 9
<212> PRT
<213> Gallus gallus

<400> 36
Gly Ser Ala Asp Asn Ser Gly Ala Ala
 1               5                  


<210> 37
<211> 14
<212> PRT
<213> Gallus gallus

<400> 37
Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr Tyr Tyr Gly
 1               5                  10                  


<210> 38
<211> 24
<212> PRT
<213> Gallus gallus

<400> 38
Pro Gly Glu Thr Val Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr
 1               5                  10                  15      
Tyr Ala Gly Ser Tyr Tyr Tyr Gly
            20                  


<210> 39
<211> 7
<212> PRT
<213> Gallus gallus

<400> 39
Tyr Asn Asn Lys Arg Pro Ser
 1               5          


<210> 40
<211> 18
<212> PRT
<213> Gallus gallus

<400> 40
Ala Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Tyr Asn Asn Lys Arg
 1               5                  10                  15      
Pro Ser
        


<210> 41
<211> 9
<212> PRT
<213> Gallus gallus

<400> 41
Gly Ser Ile Asp Asn Ser Gly Ala Ala
 1               5                  


<210> 42
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized PS4 light chain sequence

<400> 42
Ala Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val
        35                  40                  45              
Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
    50                  55                  60                  
Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Ser Gly Val Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ile Asp Asn Ser Gly
                85                  90                  95      
Ala Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val
        195                 200                 205             
Ala Pro Thr Glu Cys Ser
    210                 


<210> 43
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for humanized PS4 light chain

<400> 43
atggcctgga ttcctctact tctccccctc ctcactctct gcacaggatc cgaggccgcc 60
ctcacgcagc ccccttccgt atcagtgtcg ccgggtcaga ccgcgaggat cacatgctcg 120
ggtggagggt cgagctatta cgccgggtcc tattactatg ggtggtacca gcaaaaaccc 180
ggacaggcgc cagtgactgt catctactat aacaacaagc gccccagcgg gattccggaa 240
agattctcgg gaagcctttc cggatcgacg aataccctga ctatttcggg ggtacaggcc 300
gaagatgagg ctgactacta ttgtggctca atcgacaatt ccggagcggc atttggaggc 360
ggtacaaagt tgacggtcct tggtcagccc aaggctgccc cctcggtcac cctgttcccg 420
ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc 480
tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg 540
gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc 600
ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg 660
agcaccgtgg agaagacagt ggcccctaca gaatgttcat ag                    702

<210> 44
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized PS4 light chain sequence

<400> 44
Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val
        35                  40                  45              
Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
    50                  55                  60                  
Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Ser Gly Val Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ile Asp Asn Ser Gly
                85                  90                  95      
Ala Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val
        195                 200                 205             
Ala Pro Thr Glu Cys Ser
    210                 


<210> 45
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for humanized PS4 light chain
      

<400> 45
atggcctgga ttcctctact tctccccctc ctcactctct gcacaggatc cgaggccgag 60
ctcacgcagc ccccttccgt atcagtgtcg ccgggtcaga ccgcgaggat cacatgctcg 120
ggtggagggt cgagctatta cgccgggtcc tattactatg ggtggtacca gcaaaaaccc 180
ggacaggcgc cagtgactgt catctactat aacaacaagc gccccagcgg gattccggaa 240
agattctcgg gaagcctttc cggatcgacg aataccctga ctatttcggg ggtacaggcc 300
gaagatgagg ctgactacta ttgtggctca atcgacaatt ccggagcggc atttggaggc 360
ggtacaaagt tgacggtcct tggtcagccc aaggctgccc cctcggtcac cctgttcccg 420
ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc 480
tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg 540
gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc 600
ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg 660
agcaccgtgg agaagacagt ggcccctaca gaatgttcat ag                    702

<210> 46
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized PS4 heavy chain sequence
      

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 47
<211> 1425
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for humanized PS4 heavy chain
      

<400> 47
atggagttcg gcctgagctg gctgttcctg gtggccatcc ttaagggcgt gcagtgcgag 60
gtccagcttg tagaatcagg aggaggtttg gtgcaacccg gagggtcact gcgcctctcg 120
tgcgcggcat cagggtttac gttctcctcg tatgatatgt tctgggtgag gcaggcccct 180
ggcaaagggc tggagtgggt ggcgggtatt gatgacgacg gatcgggcag acggtacgca 240
ccggccgtca agggacgagc gaccatcagc cgcgataaca gcaagaacac gttgtatctc 300
cagatgaatt cccttcgggc tgaggacacc gcggtctact attgtacaaa atgtgcgtat 360
tcgagcggat gcgattacga agggggttac atcgacgcat ggggacaggg gacgctggtc 420
actgtgtcgt ccgctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag 480
agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg 540
gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc 600
ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg 660
ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag 720
aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa 780
ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc 840
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc 900
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag 960
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg 1020
ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag 1080
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca 1140
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat 1200
cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc 1260
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac 1320
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac 1380
aaccactaca cacagaagag cctctccctg tctccgggta aatga                 1425

<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine-serine polymer linker peptide
      

<400> 48
Gly Ser Gly Gly Ser
 1               5  


<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine-serine polymer linker peptide
      

<400> 49
Gly Gly Gly Gly Ser
 1               5  


<210> 50
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine-serine polymer linker peptide
      

<400> 50
Gly Gly Gly Ser
 1              


<210> 51
<211> 993
<212> DNA
<213> Homo sapiens

<400> 51
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 900
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca 960
cagaagagcc tctccctgtc tccgggtaaa tga                              993

<210> 52
<211> 330
<212> PRT
<213> Homo sapiens

<400> 52
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 53
<211> 321
<212> DNA
<213> Homo sapiens

<400> 53
ggtcagccca aggctgcccc ctcggtcacc ctgttcccgc cctcctctga ggagcttcaa 60
gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg 120
gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa 180
caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag 240
tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg 300
gcccctacag aatgttcata g                                           321

<210> 54
<211> 106
<212> PRT
<213> Homo sapiens

<400> 54
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105     


<210> 55
<211> 18
<212> PRT
<213> Gallus gallus

<400> 55
Ala Pro Gly Ser Ala Leu Val Thr Leu Ile Tyr Tyr Asn Asn Lys Arg
 1               5                  10                  15      
Pro Ser
        


<210> 56
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized PS4 light chain sequence

<400> 56
Ala Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val
        35                  40                  45              
Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
    50                  55                  60                  
Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Ser Gly Val Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ile Asp Asn Ser Gly
                85                  90                  95      
Ala Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 57
<211> 110
<212> PRT
<213> Homo sapiens

<400> 57
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly
            20                  25                  30          
Ser Tyr Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val
        35                  40                  45              
Leu Val Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg
    50                  55                  60                  
Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly
65                  70                  75                  80  
Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ile Asp Asn
                85                  90                  95      
Ser Gly Ala Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 58
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized PS4 heavy chain sequence

<400> 58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 59
<211> 125
<212> PRT
<213> Homo sapiens

<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 60
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized FS24 light chain with human lambda light
      chain constant region

<400> 60
Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Leu
        35                  40                  45              
Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
    50                  55                  60                  
Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Ser Gly Val Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ile Asp Asn Ser Gly
                85                  90                  95      
Ala Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val
        195                 200                 205             
Ala Pro Thr Glu Cys Ser
    210                 


<210> 61
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for humanized FS24 light chain

<400> 61
atggcctgga ttcctctact tctccccctc ctcactctct gcacaggatc cgaggccgag 60
ctcacgcagc ccccttccgt atcagtgtcg ccgggtcaga ccgcgaggat cacatgctcg 120
ggtggagggt cgagctatta cgccgggtcc tattactatg ggtggtacca gcaaaaaccc 180
ggacaggcgc cagtgactct gatctactat aacaacaagc gccccagcgg gattccggaa 240
agattctcgg gaagcctttc cggatcgacg aataccctga ctatttcggg ggtacaggcc 300
gaagatgagg ctgactacta ttgtggctca atcgacaatt ccggagcggc atttggaggc 360
ggtacaaagt tgacggtcct tggtcagccc aaggctgccc cctcggtcac cctgttcccg 420
ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc 480
tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg 540
gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc 600
ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg 660
agcaccgtgg agaagacagt ggcccctaca gaatgttcat ag                    702

<210> 62
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized FS24 heavy chain with human IgG1
      constant region

<400> 62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Tyr Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Gly Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 63
<211> 1425
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for humanized FS24 heavy chain

<400> 63
atggagttcg gcctgagctg gctgttcctg gtggccatcc ttaagggcgt gcagtgcgag 60
gtccagttgg tcgaatccgg agggggattg gtgcagcccg gtgggtcgct ccggctgtcg 120
tgcgccgcaa gcggttttac tttctcgtcg tatgatatgg cctgggtgcg ccaagcaccg 180
gggaaagggc ttgagtgggt agcggggatc gactacgacg gatcaggacg gcgctatgcg 240
ccagcagtga agggccgagc gacgatttca agagataact cgaaaaacac actgtacctc 300
caaatgaata gcttgagggc tgaagatacc gccgtctact attgtacgaa gtgcgggtac 360
acgggaggct gtgactatga gggaggctac atcgacgcgt ggggtcaggg gactcttgta 420
acagtgtcct cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag 480
agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg 540
gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc 600
ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg 660
ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag 720
aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa 780
ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc 840
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc 900
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag 960
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg 1020
ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag 1080
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca 1140
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat 1200
cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc 1260
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac 1320
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac 1380
aaccactaca cacagaagag cctctccctg tctccgggta aatga                 1425

<210> 64
<211> 125
<212> PRT
<213> Gallus gallus

<400> 64
Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly
 1               5                  10                  15      
Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 125 


<210> 65
<211> 125
<212> PRT
<213> Gallus gallus

<400> 65
Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly
 1               5                  10                  15      
Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Ala Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 125 


<210> 66
<211> 125
<212> PRT
<213> Gallus gallus

<400> 66
Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly
 1               5                  10                  15      
Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Ala Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Ala Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 125 


<210> 67
<211> 125
<212> PRT
<213> Gallus gallus

<400> 67
Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly
 1               5                  10                  15      
Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Ala Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Tyr Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Gly Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 125 


<210> 68
<211> 125
<212> PRT
<213> Gallus gallus

<400> 68
Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly
 1               5                  10                  15      
Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Phe Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 125 


<210> 69
<211> 375
<212> DNA
<213> Gallus Gallus

<400> 69
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccgggggagc gctcagcctc 60
gtctgcaagg cctccgggtt caccttcagc agtaacgcca tgggttgggt gcgacaggcg 120
cccggcaagg ggctggagtg ggtcgctggt attgatgatg atggtagtgg cacaagatac 180
gcgccggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgagg 240
ctgcagctga acaacctcag ggctgaggac accggcacct actactgcac gaaatgtgct 300
tacagtagtg gttgtgatta tgaaggtggt tatatcgacg catggggcca cgggaccgaa 360
gtcatcgtct cctcc                                                  375

<210> 70
<211> 375
<212> DNA
<213> Gallus gallus

<400> 70
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccgggggagc gctcagcctc 60
gtctgcaagg cctccgggtt caccttcagc agttacgaca tggcctgggt gcgacaggag 120
cccggcaagg ggctggagtg ggtcgctggt attgatgatg atggtagtgg cagaagatac 180
gcgccggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgagg 240
ctgcagctga acaacctcag ggctgaggac accggcacct attactgcac gaaatgtgct 300
tacagtagtg gttgtgatta tgaaggtggt tatatcgacg catggggcca cgggaccgaa 360
gtcatcgtct cctcc                                                  375

<210> 71
<211> 375
<212> DNA
<213> Gallus gallus

<400> 71
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccgggggagc gctcagcctc 60
gtctgcaagg cctccgggtt caccttcagc agttacgaca tggcctgggt gcgacaggag 120
cccggcaagg ggctggagtg ggtcgctggt attgatgatg atggtagtgg cagaagatac 180
gcgccggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgagg 240
ctgcagctga acaacctcag ggctgaggac accggcacct attactgcac gaaatgtgct 300
tacactggtg gttgtgatta tgaaggtggt tatatcgacg catggggcca cgggaccgaa 360
gtcatcgtct cctcc                                                  375

<210> 72
<211> 375
<212> DNA
<213> Gallus gallus

<400> 72
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccgggggagc gctcagcctc 60
gtctgcaagg cctccgggtt caccttcagc agttacgaca tggcctgggt gcgacaggag 120
cccggcaagg ggctggagtg ggtcgctggt attgattatg atggtagtgg cagaagatac 180
gcgccggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgagg 240
ctgcagctga acaacctcag ggctgaggac accggcacct attactgcac gaaatgtggt 300
tacactggtg gttgtgatta tgaaggtggt tatatcgacg catggggcca cgggaccgaa 360
gtcatcgtct cctcc                                                  375

<210> 73
<211> 375
<212> DNA
<213> Gallus gallus

<400> 73
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccgggggagc gctcagcctc 60
gtctgcaagg cctccgggtt caccttcagc agttacgaca tgttctgggt gcgacaggag 120
cccggcaagg ggctggagtg ggtcgctggt attgatgatg atggtagtgg cagaagatac 180
gcgccggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgagg 240
ctgcagctga acaacctcag ggctgaggac accggcacct attactgcac gaaatgtgct 300
tacagtagtg gttgtgatta tgaaggtggt tatatcgacg catggggcca cgggaccgaa 360
gtcatcgtct cctcc                                                  375

<210> 74
<211> 5
<212> PRT
<213> Gallus gallus

<400> 74
Ser Asn Ala Met Gly
 1               5  


<210> 75
<211> 17
<212> PRT
<213> Gallus gallus

<400> 75
Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val Lys
 1               5                  10                  15      
Gly
    


<210> 76
<211> 16
<212> PRT
<213> Gallus gallus

<400> 76
Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp Ala
 1               5                  10                  15      


<210> 77
<211> 5
<212> PRT
<213> Gallus gallus

<400> 77
Ser Tyr Asp Met Phe
 1               5  


<210> 78
<211> 10
<212> PRT
<213> Gallus gallus

<400> 78
Ser Tyr Asp Met Phe Trp Val Arg Gln Glu
 1               5                  10  


<210> 79
<211> 5
<212> PRT
<213> Gallus gallus

<400> 79
Ser Tyr Asp Met Ala
 1               5  


<210> 80
<211> 10
<212> PRT
<213> Gallus gallus

<400> 80
Ser Tyr Asp Met Ala Trp Val Arg Gln Glu
 1               5                  10  


<210> 81
<211> 17
<212> PRT
<213> Gallus gallus

<400> 81
Gly Ile Asp Asp Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
 1               5                  10                  15      
Gly
    


<210> 82
<211> 17
<212> PRT
<213> Gallus gallus

<400> 82
Gly Ile Asp Tyr Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
 1               5                  10                  15      
Gly
    


<210> 83
<211> 16
<212> PRT
<213> Gallus gallus

<400> 83
Cys Ala Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp Ala
 1               5                  10                  15      


<210> 84
<211> 16
<212> PRT
<213> Gallus gallus

<400> 84
Cys Gly Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp Ala
 1               5                  10                  15      


<210> 85
<211> 13
<212> PRT
<213> Gallus gallus

<400> 85
Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr Gly
 1               5                  10              


<210> 86
<211> 15
<212> PRT
<213> Gallus gallus

<400> 86
Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr Tyr Tyr Gly
 1               5                  10                  15  


<210> 87
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> human V lamda subgroup III consensus sequence

<220> 
<221> VARIANT        
<222> 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,
53, 54, 55, 56, 57, 58, 59, 92, 93, 94, 95, 96, 97, 98,
99, 100
<223> Xaa = Any Amino Acid

<400> 87
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val
        35                  40                  45              
Leu Val Ile Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ile Pro Glu Arg
    50                  55                  60                  
Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly
65                  70                  75                  80  
Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Xaa Xaa Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 88
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> human VH subgroup III consensus sequence

<220> 
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 99, 100, 101, 102, 103, 104,
105, 106, 107, 108, 109, 110, 111, 112, 113, 114
<223> Xaa = Any Amino Acid

<400> 88
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 89
<211> 129
<212> PRT
<213> Homo sapiens

<400> 89
Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly
 1               5                  10                  15      
Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly
            20                  25                  30          
Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys
        35                  40                  45              
Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys
    50                  55                  60                  
Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro
65                  70                  75                  80  
Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser
                85                  90                  95      
Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr
            100                 105                 110         
Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile
        115                 120                 125             
Gln
    


<210> 90
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized FS24 heavy chain variable region

<400> 90
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Tyr Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Gly Tyr Thr Gly Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 91
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized FS24 light chain variable region

<400> 91
Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Ser Gly Gly Gly Ser Ser Tyr Tyr Ala Gly Ser Tyr
            20                  25                  30          
Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Leu
        35                  40                  45              
Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
    50                  55                  60                  
Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Ser Gly Val Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ile Asp Asn Ser Gly
                85                  90                  95      
Ala Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 92
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus VHCDR2 of FS24, FS17 and FS10

<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Asp or Tyr


<400> 92
Gly Ile Asp Xaa Asp Gly Ser Gly Arg Arg Tyr Ala Pro Ala Val Lys
 1               5                  10                  15
Gly


<210> 93
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus VHCDR3 of FS24, FS17, and and FS10

<220>
<221>  VARIANT        
<222>  (2)...(2)
<223>  Xaa =  Ala or Gly

<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Ser or Thr

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ser or Gly


<400> 93
Cys Xaa Tyr Xaa Xaa Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp Ala
 1               5                  10                  15

<210> 94
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus VLCDR3 of FS24, FS17 and FS10

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Ala or Ile


<400> 94
Gly Ser Xaa Asp Asn Ser Gly Ala Ala
 1               5
