                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  STROMAL DERIVED FACTOR AS A TARGET AND TREATMENT FOR ANGIOGENESIS
        RELATED DISEASES

<130>  P11455-02

<150>  61/450,455
<151>  2011-03-08

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  1464
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1464)
<223>  Human collagen alpha-1(I) chain

<220>
<221>  SIGNAL
<222>  (1)..(22)
<223>  Signal Peptide

<220>
<221>  PROPEP
<222>  (23)..(161)
<223>  N-terminal propeptide

<220>
<221>  CHAIN
<222>  (162)..(1218)
<223>  Collagen alpha-1(I) chain

<220>
<221>  PROPEP
<222>  (1219)..(1464)
<223>  C-terminal propeptide (PICP)

<400>  1

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Thr  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  2
<211>  246
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PROPEP
<222>  (1)..(246)
<223>  Procollagen (I) c-terminal propeptide (PICP)

<400>  2

Asp Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr 
1               5                   10                  15      


Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly 
            20                  25                  30          


Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His 
        35                  40                  45              


Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys 
    50                  55                  60                  


Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr 
65                  70                  75                  80  


Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile 
                85                  90                  95      


Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met 
            100                 105                 110         


Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala 
        115                 120                 125             


Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala 
    130                 135                 140                 


Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp 
145                 150                 155                 160 


Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser Asn 
                165                 170                 175     


Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val 
            180                 185                 190         


Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val 
        195                 200                 205             


Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp Val 
    210                 215                 220                 


Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val 
225                 230                 235                 240 


Gly Pro Val Cys Phe Leu 
                245     


<210>  3
<211>  1466
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1466)
<223>  Human collagen alpha-1(III) chain

<220>
<221>  CHAIN
<222>  (1)..(23)
<223>  Signal peptide (potential)

<220>
<221>  PROPEP
<222>  (24)..(153)
<223>  N-terminal propeptide

<220>
<221>  CHAIN
<222>  (154)..(1221)
<223>  Collagen alpha-1(III) chain

<220>
<221>  PROPEP
<222>  (1222)..(1466)
<223>  C-terminal propeptide

<400>  3

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Thr Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Thr Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val His 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Ser  Lys Thr Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210>  4
<211>  245
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PROPEP
<222>  (1)..(245)
<223>  Procollagen (III) c-terminal propeptide (PIIICP)

<400>  4

Asp Glu Pro Met Asp Phe Lys Ile Asn Thr Asp Glu Ile Met Thr Ser 
1               5                   10                  15      


Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu Ile Ser Pro Asp Gly 
            20                  25                  30          


Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp Leu Lys Phe Cys His 
        35                  40                  45              


Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly Cys 
    50                  55                  60                  


Lys Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr 
65                  70                  75                  80  


Cys Ile Ser Ala Asn Pro Leu Asn Val Pro Arg Lys His Trp Trp Thr 
                85                  90                  95      


Asp Ser Ser Ala Glu Lys Lys His Val Trp Phe Gly Glu Ser Met Asp 
            100                 105                 110         


Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu Leu Pro Glu Asp Val 
        115                 120                 125             


Leu Asp Val His Leu Ala Phe Leu Arg Leu Leu Ser Ser Arg Ala Ser 
    130                 135                 140                 


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met Asp Gln 
145                 150                 155                 160 


Ala Ser Gly Asn Val Lys Lys Ala Leu Lys Leu Met Gly Ser Asn Glu 
                165                 170                 175     


Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe Thr Tyr Thr Val Leu 
            180                 185                 190         


Glu Asp Gly Cys Thr Lys His Thr Gly Glu Trp Ser Lys Thr Val Phe 
        195                 200                 205             


Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu Pro Ile Val Asp Ile Ala 
    210                 215                 220                 


Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu Phe Gly Val Asp Val Gly 
225                 230                 235                 240 


Pro Val Cys Phe Leu 
                245 


<210>  5
<211>  1838
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1838)
<223>  Human collagen alpha-1(V) chain

<220>
<221>  SIGNAL
<222>  (1)..(37)
<223>  Signal peptide (potential)

<220>
<221>  CHAIN
<222>  (38)..(1605)
<223>  Collagen alpha-1(V) chain

<220>
<221>  PROPEP
<222>  (1605)..(1838)
<223>  C-terminal propeptide

<400>  5

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  6
<211>  233
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PROPEP
<222>  (1)..(233)
<223>  Procollagen (V) c-terminal propeptide (PVCP)

<400>  6

Asp Gly Met Glu Glu Ile Phe Gly Ser Leu Asn Ser Leu Lys Leu Glu 
1               5                   10                  15      


Ile Glu Gln Met Lys Arg Pro Leu Gly Thr Gln Gln Asn Pro Ala Arg 
            20                  25                  30          


Thr Cys Lys Asp Leu Gln Leu Cys His Pro Asp Phe Pro Asp Gly Glu 
        35                  40                  45              


Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg Asp Ser Phe Lys Val 
    50                  55                  60                  


Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys Val Phe Pro Asp Lys 
65                  70                  75                  80  


Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro Lys Glu Asn Pro Gly 
                85                  90                  95      


Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu Leu Ser Tyr Val Asp 
            100                 105                 110         


Ala Glu Gly Asn Pro Val Gly Val Val Gln Met Thr Phe Leu Arg Leu 
        115                 120                 125             


Leu Ser Ala Ser Ala His Gln Asn Val Thr Tyr His Cys Tyr Gln Ser 
    130                 135                 140                 


Val Ala Trp Gln Asp Ala Ala Thr Gly Ser Tyr Asp Lys Ala Leu Arg 
145                 150                 155                 160 


Phe Leu Gly Ser Asn Asp Glu Glu Met Ser Tyr Asp Asn Asn Pro Tyr 
                165                 170                 175     


Ile Arg Ala Leu Val Asp Gly Cys Ala Thr Lys Lys Gly Tyr Gln Lys 
            180                 185                 190         


Thr Val Leu Glu Ile Asp Thr Pro Lys Val Glu Gln Val Pro Ile Val 
        195                 200                 205             


Asp Ile Met Phe Asn Asp Phe Gly Glu Ala Ser Gln Lys Phe Gly Phe 
    210                 215                 220                 


Glu Val Gly Pro Ala Cys Phe Met Gly 
225                 230             


<210>  7
<211>  1806
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1806)
<223>  Human collagen alpha-1(XI) chain

<220>
<221>  SIGNAL
<222>  (1)..(36)
<223>  Signal peptide (potential)

<220>
<221>  PROPEP
<222>  (37)..(511)
<223>  N-terminal propeptide

<220>
<221>  CHAIN
<222>  (512)..(1563)
<223>  Collagen alpha-1(XI) chain

<220>
<221>  PROPEP
<222>  (1564)..(1806)
<223>  C-terminal propeptide

<400>  7

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Ala Asn Ile Val Asp 
    290                 295                 300                 


Asp Phe Gln Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu 
305                 310                 315                 320 


Ala Pro Arg His Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu 
                325                 330                 335     


Ile Phe Thr Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg 
            340                 345                 350         


Lys Asn Ser Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg 
        355                 360                 365             


Asp Ser Asp Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr 
    370                 375                 380                 


Glu Tyr Lys Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu 
385                 390                 395                 400 


Phe Gly Pro Gly Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile 
                405                 410                 415     


Asn Gly His Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala 
            420                 425                 430         


Val Val Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly 
        435                 440                 445             


Pro Ala Gly Ile Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro 
    450                 455                 460                 


Pro Gly Asp Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro 
465                 470                 475                 480 


Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro 
                485                 490                 495     


Phe Arg Tyr Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln 
            500                 505                 510         


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg 
        515                 520                 525             


Gly Pro Pro Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly 
    530                 535                 540                 


Gly Pro Gly Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro 
545                 550                 555                 560 


Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro 
                565                 570                 575     


Gly Lys Arg Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly 
            580                 585                 590         


Glu Pro Gly Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
        595                 600                 605             


Pro Gly Asp Lys Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly 
625                 630                 635                 640 


Pro Arg Gly Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro 
                645                 650                 655     


Arg Gly Thr Pro Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp 
            660                 665                 670         


Gly Pro Pro Gly Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly 
        675                 680                 685             


Pro Pro Gly Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro 
    690                 695                 700                 


Gln Gly Pro Ile Gly Pro Pro Gly Glu Lys Gly Pro Gln Gly Lys Pro 
705                 710                 715                 720 


Gly Leu Ala Gly Leu Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly 
                725                 730                 735     


Lys Glu Gly Gln Ser Gly Glu Lys Gly Ala Leu Gly Pro Pro Gly Pro 
            740                 745                 750         


Gln Gly Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp 
        755                 760                 765             


Gly Val Arg Gly Leu Lys Gly Ser Lys Gly Glu Lys Gly Glu Asp Gly 
    770                 775                 780                 


Phe Pro Gly Phe Lys Gly Asp Met Gly Leu Lys Gly Asp Arg Gly Glu 
785                 790                 795                 800 


Val Gly Gln Ile Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys 
                805                 810                 815     


Gly Arg Ala Gly Pro Thr Gly Asp Pro Gly Pro Ser Gly Gln Ala Gly 
            820                 825                 830         


Glu Lys Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg 
        835                 840                 845             


Gln Gly Pro Lys Gly Ser Thr Gly Phe Pro Gly Phe Pro Gly Ala Asn 
    850                 855                 860                 


Gly Glu Lys Gly Ala Arg Gly Val Ala Gly Lys Pro Gly Pro Arg Gly 
865                 870                 875                 880 


Gln Arg Gly Pro Thr Gly Pro Arg Gly Ser Arg Gly Ala Arg Gly Pro 
                885                 890                 895     


Thr Gly Lys Pro Gly Pro Lys Gly Thr Ser Gly Gly Asp Gly Pro Pro 
            900                 905                 910         


Gly Pro Pro Gly Glu Arg Gly Pro Gln Gly Pro Gln Gly Pro Val Gly 
        915                 920                 925             


Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu 
    930                 935                 940                 


Pro Gly His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr 
945                 950                 955                 960 


Gly Pro Pro Gly Pro Gly Gly Val Val Gly Pro Gln Gly Pro Thr Gly 
                965                 970                 975     


Glu Thr Gly Pro Ile Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro 
            980                 985                 990         


Pro Gly Glu Gln Gly Leu Pro Gly  Ala Ala Gly Lys Glu  Gly Ala Lys 
        995                 1000                 1005             


Gly Asp  Pro Gly Pro Gln Gly  Ile Ser Gly Lys Asp  Gly Pro Ala 
    1010                 1015                 1020             


Gly Leu  Arg Gly Phe Pro Gly  Glu Arg Gly Leu Pro  Gly Ala Gln 
    1025                 1030                 1035             


Gly Ala  Pro Gly Leu Lys Gly  Gly Glu Gly Pro Gln  Gly Pro Pro 
    1040                 1045                 1050             


Gly Pro  Val Gly Ser Pro Gly  Glu Arg Gly Ser Ala  Gly Thr Ala 
    1055                 1060                 1065             


Gly Pro  Ile Gly Leu Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1085                 1090                 1095             


Gly Pro  Ala Gly Arg Asp Gly  Val Gln Gly Pro Val  Gly Leu Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Pro Ala Gly  Ser Pro Gly Glu Asp  Gly Asp Lys 
    1115                 1120                 1125             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1130                 1135                 1140             


Gly Glu  Asn Gly Pro Pro Gly  Pro Pro Gly Leu Gln  Gly Pro Val 
    1145                 1150                 1155             


Gly Ala  Pro Gly Ile Ala Gly  Gly Asp Gly Glu Pro  Gly Pro Arg 
    1160                 1165                 1170             


Gly Gln  Gln Gly Met Phe Gly  Gln Lys Gly Asp Glu  Gly Ala Arg 
    1175                 1180                 1185             


Gly Phe  Pro Gly Pro Pro Gly  Pro Ile Gly Leu Gln  Gly Leu Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Glu Lys Gly  Glu Asn Gly Asp Val  Gly Pro Met 
    1205                 1210                 1215             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Gln  Gly Pro Asn 
    1220                 1225                 1230             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Ser Val  Gly Ser Val 
    1235                 1240                 1245             


Gly Gly  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Asn Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Glu Ala Gly  Val Gly Gly Pro Lys  Gly Glu Arg 
    1265                 1270                 1275             


Gly Glu  Lys Gly Glu Ala Gly  Pro Pro Gly Ala Ala  Gly Pro Pro 
    1280                 1285                 1290             


Gly Ala  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Asn Pro 
    1295                 1300                 1305             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1310                 1315                 1320             


Gly Pro  Ala Gly Gln Asp Gly  Val Gly Gly Asp Lys  Gly Glu Asp 
    1325                 1330                 1335             


Gly Asp  Pro Gly Gln Pro Gly  Pro Pro Gly Pro Ser  Gly Glu Ala 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Ala Ala 
    1355                 1360                 1365             


Gly Ala  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1370                 1375                 1380             


Gly Ala  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Val  Gly Pro Gln 
    1385                 1390                 1395             


Gly Pro  Ala Gly Lys Pro Gly  Pro Glu Gly Leu Arg  Gly Ile Pro 
    1400                 1405                 1410             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ala Ala  Gly Gln Asp 
    1415                 1420                 1425             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1430                 1435                 1440             


Gly Asp  Pro Gly Ser Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1445                 1450                 1455             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1460                 1465                 1470             


Gly Leu  Pro Gly Thr Gln Gly  Ser Pro Gly Ala Lys  Gly Asp Gly 
    1475                 1480                 1485             


Gly Ile  Pro Gly Pro Ala Gly  Pro Leu Gly Pro Pro  Gly Pro Pro 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Pro Lys Gly Asn Lys  Gly Ser Thr 
    1505                 1510                 1515             


Gly Pro  Ala Gly Gln Lys Gly  Asp Ser Gly Leu Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Ser  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1535                 1540                 1545             


Leu Ser  Ser Lys Lys Thr Arg  Arg His Thr Glu Gly  Met Gln Ala 
    1550                 1555                 1560             


Asp Ala  Asp Asp Asn Ile Leu  Asp Tyr Ser Asp Gly  Met Glu Glu 
    1565                 1570                 1575             


Ile Phe  Gly Ser Leu Asn Ser  Leu Lys Gln Asp Ile  Glu His Met 
    1580                 1585                 1590             


Lys Phe  Pro Met Gly Thr Gln  Thr Asn Pro Ala Arg  Thr Cys Lys 
    1595                 1600                 1605             


Asp Leu  Gln Leu Ser His Pro  Asp Phe Pro Asp Gly  Glu Tyr Trp 
    1610                 1615                 1620             


Ile Asp  Pro Asn Gln Gly Cys  Ser Gly Asp Ser Phe  Lys Val Tyr 
    1625                 1630                 1635             


Cys Asn  Phe Thr Ser Gly Gly  Glu Thr Cys Ile Tyr  Pro Asp Lys 
    1640                 1645                 1650             


Lys Ser  Glu Gly Val Arg Ile  Ser Ser Trp Pro Lys  Glu Lys Pro 
    1655                 1660                 1665             


Gly Ser  Trp Phe Ser Glu Phe  Lys Arg Gly Lys Leu  Leu Ser Tyr 
    1670                 1675                 1680             


Leu Asp  Val Glu Gly Asn Ser  Ile Asn Met Val Gln  Met Thr Phe 
    1685                 1690                 1695             


Leu Lys  Leu Leu Thr Ala Ser  Ala Arg Gln Asn Phe  Thr Tyr His 
    1700                 1705                 1710             


Cys His  Gln Ser Ala Ala Trp  Tyr Asp Val Ser Ser  Gly Ser Tyr 
    1715                 1720                 1725             


Asp Lys  Ala Leu Arg Phe Leu  Gly Ser Asn Asp Glu  Glu Met Ser 
    1730                 1735                 1740             


Tyr Asp  Asn Asn Pro Phe Ile  Lys Thr Leu Tyr Asp  Gly Cys Ala 
    1745                 1750                 1755             


Ser Arg  Lys Gly Tyr Glu Lys  Thr Val Ile Glu Ile  Asn Thr Pro 
    1760                 1765                 1770             


Lys Ile  Asp Gln Val Pro Ile  Val Asp Val Met Ile  Asn Asp Phe 
    1775                 1780                 1785             


Gly Asp  Gln Asn Gln Lys Phe  Gly Phe Glu Val Gly  Pro Val Cys 
    1790                 1795                 1800             


Phe Leu  Gly 
    1805     


<210>  8
<211>  243
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(243)
<223>  Procollagen (XI) c-terminal propeptide (PXICP)

<400>  8

Asp Ala Asp Asp Asn Ile Leu Asp Tyr Ser Asp Gly Met Glu Glu Ile 
1               5                   10                  15      


Phe Gly Ser Leu Asn Ser Leu Lys Gln Asp Ile Glu His Met Lys Phe 
            20                  25                  30          


Pro Met Gly Thr Gln Thr Asn Pro Ala Arg Thr Cys Lys Asp Leu Gln 
        35                  40                  45              


Leu Ser His Pro Asp Phe Pro Asp Gly Glu Tyr Trp Ile Asp Pro Asn 
    50                  55                  60                  


Gln Gly Cys Ser Gly Asp Ser Phe Lys Val Tyr Cys Asn Phe Thr Ser 
65                  70                  75                  80  


Gly Gly Glu Thr Cys Ile Tyr Pro Asp Lys Lys Ser Glu Gly Val Arg 
                85                  90                  95      


Ile Ser Ser Trp Pro Lys Glu Lys Pro Gly Ser Trp Phe Ser Glu Phe 
            100                 105                 110         


Lys Arg Gly Lys Leu Leu Ser Tyr Leu Asp Val Glu Gly Asn Ser Ile 
        115                 120                 125             


Asn Met Val Gln Met Thr Phe Leu Lys Leu Leu Thr Ala Ser Ala Arg 
    130                 135                 140                 


Gln Asn Phe Thr Tyr His Cys His Gln Ser Ala Ala Trp Tyr Asp Val 
145                 150                 155                 160 


Ser Ser Gly Ser Tyr Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp 
                165                 170                 175     


Glu Glu Met Ser Tyr Asp Asn Asn Pro Phe Ile Lys Thr Leu Tyr Asp 
            180                 185                 190         


Gly Cys Ala Ser Arg Lys Gly Tyr Glu Lys Thr Val Ile Glu Ile Asn 
        195                 200                 205             


Thr Pro Lys Ile Asp Gln Val Pro Ile Val Asp Val Met Ile Asn Asp 
    210                 215                 220                 


Phe Gly Asp Gln Asn Gln Lys Phe Gly Phe Glu Val Gly Pro Val Cys 
225                 230                 235                 240 


Phe Leu Gly 
            


<210>  9
<211>  1860
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Collagen alpha-1(XXVII) chain

<220>
<221>  SIGNAL
<222>  (1)..(41)
<223>  Signal peptide (potential)

<220>
<221>  PROPEP
<222>  (42)..(624)
<223>  N-terminal propeptide

<220>
<221>  CHAIN
<222>  (625)..(1621)
<223>  Collagen alpha-1(XXVII) chain

<220>
<221>  PROPEP
<222>  (1622)..(1860)
<223>  C-terminal propeptide

<400>  9

Met Gly Ala Gly Ser Ala Arg Gly Ala Arg Gly Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Arg Gly Gly Gly Phe Leu Phe Ser Trp Ile Leu Val Ser Phe 
            20                  25                  30          


Ala Cys His Leu Ala Ser Thr Gln Gly Ala Pro Glu Asp Val Asp Ile 
        35                  40                  45              


Leu Gln Arg Leu Gly Leu Ser Trp Thr Lys Ala Gly Ser Pro Ala Pro 
    50                  55                  60                  


Pro Gly Val Ile Pro Phe Gln Ser Gly Phe Ile Phe Thr Gln Arg Ala 
65                  70                  75                  80  


Arg Leu Gln Ala Pro Thr Gly Thr Val Ile Pro Ala Ala Leu Gly Thr 
                85                  90                  95      


Glu Leu Ala Leu Val Leu Ser Leu Cys Ser His Arg Val Asn His Ala 
            100                 105                 110         


Phe Leu Phe Ala Val Arg Ser Gln Lys Arg Lys Leu Gln Leu Gly Leu 
        115                 120                 125             


Gln Phe Leu Pro Gly Lys Thr Val Val His Leu Gly Ser Arg Arg Ser 
    130                 135                 140                 


Val Ala Phe Asp Leu Asp Met His Asp Gly Arg Trp His His Leu Ala 
145                 150                 155                 160 


Leu Glu Leu Arg Gly Arg Thr Val Thr Leu Val Thr Ala Cys Gly Gln 
                165                 170                 175     


Arg Arg Val Pro Val Leu Leu Pro Phe His Arg Asp Pro Ala Leu Asp 
            180                 185                 190         


Pro Gly Gly Ser Phe Leu Phe Gly Lys Met Asn Pro His Ala Val Gln 
        195                 200                 205             


Phe Glu Gly Ala Leu Cys Gln Phe Ser Ile Tyr Pro Val Thr Gln Val 
    210                 215                 220                 


Ala His Asn Tyr Cys Thr His Leu Arg Lys Gln Cys Gly Gln Ala Asp 
225                 230                 235                 240 


Thr Tyr Gln Ser Pro Leu Gly Pro Leu Phe Ser Gln Asp Ser Gly Arg 
                245                 250                 255     


Pro Phe Thr Phe Gln Ser Asp Leu Ala Leu Leu Gly Leu Glu Asn Leu 
            260                 265                 270         


Thr Thr Ala Thr Pro Ala Leu Gly Ser Leu Pro Ala Gly Arg Gly Pro 
        275                 280                 285             


Arg Gly Thr Val Ala Pro Ala Thr Pro Thr Lys Pro Gln Arg Thr Ser 
    290                 295                 300                 


Pro Thr Asn Pro His Gln His Met Ala Val Gly Gly Pro Ala Gln Thr 
305                 310                 315                 320 


Pro Leu Leu Pro Ala Lys Leu Ser Ala Ser Asn Ala Leu Asp Pro Met 
                325                 330                 335     


Leu Pro Ala Ser Val Gly Gly Ser Thr Arg Thr Pro Arg Pro Ala Ala 
            340                 345                 350         


Ala Gln Pro Ser Gln Lys Ile Thr Ala Thr Lys Ile Pro Lys Ser Leu 
        355                 360                 365             


Pro Thr Lys Pro Ser Ala Pro Ser Thr Ser Ile Val Pro Ile Lys Ser 
    370                 375                 380                 


Pro His Pro Thr Gln Lys Thr Ala Pro Ser Ser Phe Thr Lys Ser Ala 
385                 390                 395                 400 


Leu Pro Thr Gln Lys Gln Val Pro Pro Thr Ser Arg Pro Val Pro Ala 
                405                 410                 415     


Arg Val Ser Arg Pro Ala Glu Lys Pro Ile Gln Arg Asn Pro Gly Met 
            420                 425                 430         


Pro Arg Pro Pro Pro Pro Ser Thr Arg Pro Leu Pro Pro Thr Thr Ser 
        435                 440                 445             


Ser Ser Lys Lys Pro Ile Pro Thr Leu Ala Arg Thr Glu Ala Lys Ile 
    450                 455                 460                 


Thr Ser His Ala Ser Lys Pro Ala Ser Ala Arg Thr Ser Thr His Lys 
465                 470                 475                 480 


Pro Pro Pro Phe Thr Ala Leu Ser Ser Ser Pro Ala Pro Thr Pro Gly 
                485                 490                 495     


Ser Thr Arg Ser Thr Arg Pro Pro Ala Thr Met Val Pro Pro Thr Ser 
            500                 505                 510         


Gly Thr Ser Thr Pro Arg Thr Ala Pro Ala Val Pro Thr Pro Gly Ser 
        515                 520                 525             


Ala Pro Thr Gly Ser Lys Lys Pro Ile Gly Ser Glu Ala Ser Lys Lys 
    530                 535                 540                 


Ala Gly Pro Lys Ser Ser Pro Arg Lys Pro Val Pro Leu Arg Pro Gly 
545                 550                 555                 560 


Lys Ala Ala Arg Asp Val Pro Leu Ser Asp Leu Thr Thr Arg Pro Ser 
                565                 570                 575     


Pro Arg Gln Pro Gln Pro Ser Gln Gln Thr Thr Pro Ala Leu Val Leu 
            580                 585                 590         


Ala Pro Ala Gln Phe Leu Ser Ser Ser Pro Arg Pro Thr Ser Ser Gly 
        595                 600                 605             


Tyr Ser Ile Phe His Leu Ala Gly Ser Thr Pro Phe Pro Leu Leu Met 
    610                 615                 620                 


Gly Pro Pro Gly Pro Lys Gly Asp Cys Gly Leu Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Leu Pro Gly Leu Pro Gly Ile Pro Gly Ala Arg Gly Pro Arg Gly Pro 
                645                 650                 655     


Pro Gly Pro Tyr Gly Asn Pro Gly Leu Pro Gly Pro Pro Gly Ala Lys 
            660                 665                 670         


Gly Gln Lys Gly Asp Pro Gly Leu Ser Pro Gly Lys Ala His Asp Gly 
        675                 680                 685             


Ala Lys Gly Asp Met Gly Leu Pro Gly Leu Ser Gly Asn Pro Gly Pro 
    690                 695                 700                 


Pro Gly Arg Lys Gly His Lys Gly Tyr Pro Gly Pro Ala Gly His Pro 
705                 710                 715                 720 


Gly Glu Gln Gly Gln Pro Gly Pro Glu Gly Ser Pro Gly Ala Lys Gly 
                725                 730                 735     


Tyr Pro Gly Arg Gln Gly Leu Pro Gly Pro Val Gly Asp Pro Gly Pro 
            740                 745                 750         


Lys Gly Ser Arg Gly Tyr Ile Gly Leu Pro Gly Leu Phe Gly Leu Pro 
        755                 760                 765             


Gly Ser Asp Gly Glu Arg Gly Leu Pro Gly Val Pro Gly Lys Arg Gly 
    770                 775                 780                 


Lys Met Gly Met Pro Gly Phe Pro Gly Val Phe Gly Glu Arg Gly Pro 
785                 790                 795                 800 


Pro Gly Leu Asp Gly Asn Pro Gly Glu Leu Gly Leu Pro Gly Pro Pro 
                805                 810                 815     


Gly Val Pro Gly Leu Ile Gly Asp Leu Gly Val Leu Gly Pro Ile Gly 
            820                 825                 830         


Tyr Pro Gly Pro Lys Gly Met Lys Gly Leu Met Gly Ser Val Gly Glu 
        835                 840                 845             


Pro Gly Leu Lys Gly Asp Lys Gly Glu Gln Gly Val Pro Gly Val Ser 
    850                 855                 860                 


Gly Asp Pro Gly Phe Gln Gly Asp Lys Gly Ser Gln Gly Leu Pro Gly 
865                 870                 875                 880 


Phe Pro Gly Ala Arg Gly Lys Pro Gly Pro Leu Gly Lys Val Gly Asp 
                885                 890                 895     


Lys Gly Ser Ile Gly Phe Pro Gly Pro Pro Gly Pro Glu Gly Phe Pro 
            900                 905                 910         


Gly Asp Ile Gly Pro Pro Gly Asp Asn Gly Pro Glu Gly Met Lys Gly 
        915                 920                 925             


Lys Pro Gly Ala Arg Gly Leu Pro Gly Pro Arg Gly Gln Leu Gly Pro 
    930                 935                 940                 


Glu Gly Asp Glu Gly Pro Met Gly Pro Pro Gly Ala Pro Gly Leu Glu 
945                 950                 955                 960 


Gly Gln Pro Gly Arg Lys Gly Phe Pro Gly Arg Pro Gly Leu Asp Gly 
                965                 970                 975     


Val Lys Gly Glu Pro Gly Asp Pro Gly Arg Pro Gly Pro Val Gly Glu 
            980                 985                 990         


Gln Gly Phe Met Gly Phe Ile Gly  Leu Val Gly Glu Pro  Gly Ile Val 
        995                 1000                 1005             


Gly Glu  Lys Gly Asp Arg Gly  Met Met Gly Pro Pro  Gly Val Pro 
    1010                 1015                 1020             


Gly Pro  Lys Gly Ser Met Gly  His Pro Gly Met Pro  Gly Gly Met 
    1025                 1030                 1035             


Gly Thr  Pro Gly Glu Pro Gly  Pro Gln Gly Pro Pro  Gly Ser Arg 
    1040                 1045                 1050             


Gly Pro  Pro Gly Met Arg Gly  Ala Lys Gly Arg Arg  Gly Pro Arg 
    1055                 1060                 1065             


Gly Pro  Asp Gly Pro Ala Gly  Glu Gln Gly Ser Arg  Gly Leu Lys 
    1070                 1075                 1080             


Gly Pro  Pro Gly Pro Gln Gly  Arg Pro Gly Arg Pro  Gly Gln Gln 
    1085                 1090                 1095             


Gly Val  Ala Gly Glu Arg Gly  His Leu Gly Ser Arg  Gly Phe Pro 
    1100                 1105                 1110             


Gly Ile  Pro Gly Pro Ser Gly  Pro Pro Gly Thr Lys  Gly Leu Pro 
    1115                 1120                 1125             


Gly Glu  Pro Gly Pro Gln Gly  Pro Gln Gly Pro Ile  Gly Pro Pro 
    1130                 1135                 1140             


Gly Glu  Met Gly Pro Lys Gly  Pro Pro Gly Ala Val  Gly Glu Pro 
    1145                 1150                 1155             


Gly Leu  Pro Gly Glu Ala Gly  Met Lys Gly Asp Leu  Gly Pro Leu 
    1160                 1165                 1170             


Gly Thr  Pro Gly Glu Gln Gly  Leu Ile Gly Gln Arg  Gly Glu Pro 
    1175                 1180                 1185             


Gly Leu  Glu Gly Asp Ser Gly  Pro Met Gly Pro Asp  Gly Leu Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Asp Pro Gly  Pro Asp Gly Glu His  Gly Glu Lys 
    1205                 1210                 1215             


Gly Gln  Glu Gly Leu Met Gly  Glu Asp Gly Pro Pro  Gly Pro Pro 
    1220                 1225                 1230             


Gly Val  Thr Gly Val Arg Gly  Pro Glu Gly Lys Ser  Gly Lys Gln 
    1235                 1240                 1245             


Gly Glu  Lys Gly Arg Thr Gly  Ala Lys Gly Ala Lys  Gly Tyr Gln 
    1250                 1255                 1260             


Gly Gln  Leu Gly Glu Met Gly  Val Pro Gly Asp Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Thr  Pro Gly Pro Lys Gly  Ser Arg Gly Ser Leu  Gly Pro Thr 
    1280                 1285                 1290             


Gly Ala  Pro Gly Arg Met Gly  Ala Gln Gly Glu Pro  Gly Leu Ala 
    1295                 1300                 1305             


Gly Tyr  Asp Gly His Lys Gly  Ile Val Gly Pro Leu  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Glu Lys Gly  Glu Gln Gly Glu Asp  Gly Lys Ala 
    1325                 1330                 1335             


Glu Gly  Pro Pro Gly Pro Pro  Gly Asp Arg Gly Pro  Val Gly Asp 
    1340                 1345                 1350             


Arg Gly  Asp Arg Gly Glu Pro  Gly Asp Pro Gly Tyr  Pro Gly Gln 
    1355                 1360                 1365             


Glu Gly  Val Gln Gly Leu Arg  Gly Lys Pro Gly Gln  Gln Gly Gln 
    1370                 1375                 1380             


Pro Gly  His Pro Gly Pro Arg  Gly Trp Pro Gly Pro  Lys Gly Ser 
    1385                 1390                 1395             


Lys Gly  Ala Glu Gly Pro Lys  Gly Lys Gln Gly Lys  Ala Gly Ala 
    1400                 1405                 1410             


Pro Gly  Arg Arg Gly Val Gln  Gly Leu Gln Gly Leu  Pro Gly Pro 
    1415                 1420                 1425             


Arg Gly  Val Val Gly Arg Gln  Gly Leu Glu Gly Ile  Ala Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Pro Gly Arg Asp  Gly Gln Ala Gly Gln  Gln Gly Glu 
    1445                 1450                 1455             


Gln Gly  Asp Asp Gly Asp Pro  Gly Pro Met Gly Pro  Ala Gly Lys 
    1460                 1465                 1470             


Arg Gly  Asn Pro Gly Val Ala  Gly Leu Pro Gly Ala  Gln Gly Pro 
    1475                 1480                 1485             


Pro Gly  Phe Lys Gly Glu Ser  Gly Leu Pro Gly Gln  Leu Gly Pro 
    1490                 1495                 1500             


Pro Gly  Lys Arg Gly Thr Glu  Gly Arg Thr Gly Leu  Pro Gly Asn 
    1505                 1510                 1515             


Gln Gly  Glu Pro Gly Ser Lys  Gly Gln Pro Gly Asp  Ser Gly Glu 
    1520                 1525                 1530             


Met Gly  Phe Pro Gly Met Ala  Gly Leu Phe Gly Pro  Lys Gly Pro 
    1535                 1540                 1545             


Pro Gly  Asp Ile Gly Phe Lys  Gly Ile Gln Gly Pro  Arg Gly Pro 
    1550                 1555                 1560             


Pro Gly  Leu Met Gly Lys Glu  Gly Ile Val Gly Pro  Leu Gly Ile 
    1565                 1570                 1575             


Leu Gly  Pro Ser Gly Leu Pro  Gly Pro Lys Gly Asp  Lys Gly Ser 
    1580                 1585                 1590             


Arg Gly  Asp Trp Gly Leu Gln  Gly Pro Arg Gly Pro  Pro Gly Pro 
    1595                 1600                 1605             


Arg Gly  Arg Pro Gly Pro Pro  Gly Pro Pro Gly Gly  Pro Ile Gln 
    1610                 1615                 1620             


Leu Gln  Gln Asp Asp Leu Gly  Ala Ala Phe Gln Thr  Trp Met Asp 
    1625                 1630                 1635             


Thr Ser  Gly Ala Leu Arg Pro  Glu Ser Tyr Ser Tyr  Pro Asp Arg 
    1640                 1645                 1650             


Leu Val  Leu Asp Gln Gly Gly  Glu Ile Phe Lys Thr  Leu His Tyr 
    1655                 1660                 1665             


Leu Ser  Asn Leu Ile Gln Ser  Ile Lys Thr Pro Leu  Gly Thr Lys 
    1670                 1675                 1680             


Glu Asn  Pro Ala Arg Val Cys  Arg Asp Leu Met Asp  Cys Glu Gln 
    1685                 1690                 1695             


Lys Met  Val Asp Gly Thr Tyr  Trp Val Asp Pro Asn  Leu Gly Cys 
    1700                 1705                 1710             


Ser Ser  Asp Thr Ile Glu Val  Ser Cys Asn Phe Thr  His Gly Gly 
    1715                 1720                 1725             


Gln Thr  Cys Leu Lys Pro Ile  Thr Ala Ser Lys Val  Glu Phe Ala 
    1730                 1735                 1740             


Ile Ser  Arg Val Gln Met Asn  Phe Leu His Leu Leu  Ser Ser Glu 
    1745                 1750                 1755             


Val Thr  Gln His Ile Thr Ile  His Cys Leu Asn Met  Thr Val Trp 
    1760                 1765                 1770             


Gln Glu  Gly Thr Gly Gln Thr  Pro Ala Lys Gln Ala  Val Arg Phe 
    1775                 1780                 1785             


Arg Ala  Trp Asn Gly Gln Ile  Phe Glu Ala Gly Gly  Gln Phe Arg 
    1790                 1795                 1800             


Pro Glu  Val Ser Met Asp Gly  Cys Lys Val Gln Asp  Gly Arg Trp 
    1805                 1810                 1815             


His Gln  Thr Leu Phe Thr Phe  Arg Thr Gln Asp Pro  Gln Gln Leu 
    1820                 1825                 1830             


Pro Ile  Ile Ser Val Asp Asn  Leu Pro Pro Ala Ser  Ser Gly Lys 
    1835                 1840                 1845             


Gln Tyr  Arg Leu Glu Val Gly  Pro Ala Cys Phe Leu  
    1850                 1855                 1860 


<210>  10
<211>  239
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(239)
<223>  Procollagen (XXVII) c-terminal propeptide (PXXVIICP)

<400>  10

Ile Gln Leu Gln Gln Asp Asp Leu Gly Ala Ala Phe Gln Thr Trp Met 
1               5                   10                  15      


Asp Thr Ser Gly Ala Leu Arg Pro Glu Ser Tyr Ser Tyr Pro Asp Arg 
            20                  25                  30          


Leu Val Leu Asp Gln Gly Gly Glu Ile Phe Lys Thr Leu His Tyr Leu 
        35                  40                  45              


Ser Asn Leu Ile Gln Ser Ile Lys Thr Pro Leu Gly Thr Lys Glu Asn 
    50                  55                  60                  


Pro Ala Arg Val Cys Arg Asp Leu Met Asp Cys Glu Gln Lys Met Val 
65                  70                  75                  80  


Asp Gly Thr Tyr Trp Val Asp Pro Asn Leu Gly Cys Ser Ser Asp Thr 
                85                  90                  95      


Ile Glu Val Ser Cys Asn Phe Thr His Gly Gly Gln Thr Cys Leu Lys 
            100                 105                 110         


Pro Ile Thr Ala Ser Lys Val Glu Phe Ala Ile Ser Arg Val Gln Met 
        115                 120                 125             


Asn Phe Leu His Leu Leu Ser Ser Glu Val Thr Gln His Ile Thr Ile 
    130                 135                 140                 


His Cys Leu Asn Met Thr Val Trp Gln Glu Gly Thr Gly Gln Thr Pro 
145                 150                 155                 160 


Ala Lys Gln Ala Val Arg Phe Arg Ala Trp Asn Gly Gln Ile Phe Glu 
                165                 170                 175     


Ala Gly Gly Gln Phe Arg Pro Glu Val Ser Met Asp Gly Cys Lys Val 
            180                 185                 190         


Gln Asp Gly Arg Trp His Gln Thr Leu Phe Thr Phe Arg Thr Gln Asp 
        195                 200                 205             


Pro Gln Gln Leu Pro Ile Ile Ser Val Asp Asn Leu Pro Pro Ala Ser 
    210                 215                 220                 


Ser Gly Lys Gln Tyr Arg Leu Glu Val Gly Pro Ala Cys Phe Leu 
225                 230                 235                 


<210>  11
<211>  1487
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1487)
<223>  Human collagen alpha-1(II) chain

<400>  11

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210>  12
<211>  1714
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1714)
<223>  Human collagen alpha-1(XXIV) chain

<400>  12

Met His Leu Arg Ala His Arg Thr Arg Arg Gly Lys Val Ser Pro Thr 
1               5                   10                  15      


Ala Lys Thr Lys Ser Leu Leu His Phe Ile Val Leu Cys Val Ala Gly 
            20                  25                  30          


Val Val Val His Ala Gln Glu Gln Gly Ile Asp Ile Leu His Gln Leu 
        35                  40                  45              


Gly Leu Gly Gly Lys Asp Val Arg His Ser Ser Pro Ala Thr Ala Val 
    50                  55                  60                  


Pro Ser Ala Ser Thr Pro Leu Pro Gln Gly Val His Leu Thr Glu Ser 
65                  70                  75                  80  


Gly Val Ile Phe Lys Asn Asp Ala Tyr Ile Glu Thr Pro Phe Val Lys 
                85                  90                  95      


Ile Leu Pro Val Asn Leu Gly Gln Pro Phe Thr Ile Leu Thr Gly Leu 
            100                 105                 110         


Gln Ser His Arg Val Asn Asn Ala Phe Leu Phe Ser Ile Arg Asn Lys 
        115                 120                 125             


Asn Arg Leu Gln Leu Gly Val Gln Leu Leu Pro Lys Lys Leu Val Val 
    130                 135                 140                 


His Ile Arg Gly Lys Gln Pro Ala Val Phe Asn Tyr Ser Val His Asp 
145                 150                 155                 160 


Glu Gln Trp His Ser Phe Ala Ile Thr Ile Arg Asn Gln Ser Val Ser 
                165                 170                 175     


Met Phe Val Glu Cys Gly Lys Lys Tyr Phe Ser Thr Glu Thr Ile Pro 
            180                 185                 190         


Glu Val Gln Thr Phe Asp Ser Asn Ser Val Phe Thr Leu Gly Ser Met 
        195                 200                 205             


Asn Asn Asn Ser Ile His Phe Glu Gly Ile Val Cys Gln Leu Asp Ile 
    210                 215                 220                 


Ile Pro Ser Ala Glu Ala Ser Ala Asp Tyr Cys Arg Tyr Val Lys Gln 
225                 230                 235                 240 


Gln Cys Arg Gln Ala Asp Lys Tyr Gln Pro Glu Thr Ser Ile Pro Cys 
                245                 250                 255     


Thr Thr Leu Ile Pro Thr Lys Ile Pro Glu His Ser Pro Pro Pro Lys 
            260                 265                 270         


Leu Phe Ala Glu Lys Val Leu Ser Glu Asp Thr Phe Thr Glu Gly Lys 
        275                 280                 285             


Ser Ile Pro Asn Ile Ile Lys Asn Asp Ser Glu Thr Val Tyr Lys Arg 
    290                 295                 300                 


Gln Glu His Gln Ile Ser Arg Ser Gln Leu Ser Ser Leu Gln Ser Gly 
305                 310                 315                 320 


Asn Val Ser Ala Val Asp Leu Thr Asn His Gly Ile Gln Ala Lys Glu 
                325                 330                 335     


Met Ile Thr Glu Glu Asp Thr Gln Thr Asn Phe Ser Leu Ser Val Thr 
            340                 345                 350         


Thr His Arg Ile Ser Glu Ala Lys Met Asn Thr Lys Glu Lys Phe Ser 
        355                 360                 365             


Ser Leu Leu Asn Met Ser Asp Asn Ile Thr Gln His Asp Asp Arg Val 
    370                 375                 380                 


Thr Gly Leu Ser Leu Phe Lys Lys Met Pro Ser Ile Leu Pro Gln Ile 
385                 390                 395                 400 


Lys Gln Asp Thr Ile Thr Asn Leu Lys Lys Ala Ile Thr Ala Asn Leu 
                405                 410                 415     


His Thr Asn Glu Leu Met Glu Met Gln Pro Ile Leu Asn Thr Ser Leu 
            420                 425                 430         


His Arg Val Thr Asn Glu Pro Ser Val Asp Asn His Leu Asp Leu Arg 
        435                 440                 445             


Lys Glu Gly Glu Phe Tyr Pro Asp Ala Thr Tyr Pro Ile Glu Asn Ser 
    450                 455                 460                 


Tyr Glu Thr Glu Leu Tyr Asp Tyr Tyr Tyr Tyr Glu Asp Leu Asn Thr 
465                 470                 475                 480 


Met Leu Glu Met Glu Tyr Leu Arg Gly Pro Lys Gly Asp Thr Gly Pro 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Ala Gly Ile Pro Gly Pro Ser Gly Lys Arg 
            500                 505                 510         


Gly Pro Arg Gly Ile Pro Gly Pro His Gly Asn Pro Gly Leu Pro Gly 
        515                 520                 525             


Leu Pro Gly Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe Ser Pro Gly 
    530                 535                 540                 


Gln Pro Val Pro Gly Glu Lys Gly Asp Gln Gly Leu Ser Gly Leu Met 
545                 550                 555                 560 


Gly Pro Pro Gly Met Gln Gly Asp Lys Gly Leu Lys Gly His Pro Gly 
                565                 570                 575     


Leu Pro Gly Leu Pro Gly Glu Gln Gly Ile Pro Gly Phe Ala Gly Asn 
            580                 585                 590         


Ile Gly Ser Pro Gly Tyr Pro Gly Arg Gln Gly Leu Ala Gly Pro Glu 
        595                 600                 605             


Gly Asn Pro Gly Pro Lys Gly Ala Gln Gly Phe Ile Gly Ser Pro Gly 
    610                 615                 620                 


Glu Ala Gly Gln Leu Gly Pro Glu Gly Glu Arg Gly Ile Pro Gly Ile 
625                 630                 635                 640 


Arg Gly Lys Lys Gly Phe Lys Gly Arg Gln Gly Phe Pro Gly Asp Phe 
                645                 650                 655     


Gly Asp Arg Gly Pro Ala Gly Leu Asp Gly Ser Pro Gly Leu Val Gly 
            660                 665                 670         


Gly Thr Gly Pro Pro Gly Phe Pro Gly Leu Arg Gly Ser Val Gly Pro 
        675                 680                 685             


Val Gly Pro Ile Gly Pro Ala Gly Ile Pro Gly Pro Met Gly Leu Ser 
    690                 695                 700                 


Gly Asn Lys Gly Leu Pro Gly Ile Lys Gly Asp Lys Gly Glu Gln Gly 
705                 710                 715                 720 


Thr Ala Gly Glu Leu Gly Glu Pro Gly Tyr Pro Gly Asp Lys Gly Ala 
                725                 730                 735     


Val Gly Leu Pro Gly Pro Pro Gly Met Arg Gly Lys Ser Gly Pro Ser 
            740                 745                 750         


Gly Gln Thr Gly Asp Pro Gly Leu Gln Gly Pro Ser Gly Pro Pro Gly 
        755                 760                 765             


Pro Glu Gly Phe Pro Gly Asp Ile Gly Ile Pro Gly Gln Asn Gly Pro 
    770                 775                 780                 


Glu Gly Pro Lys Gly Leu Leu Gly Asn Arg Gly Pro Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Leu Lys Gly Thr Gln Gly Glu Glu Gly Pro Ile Gly Ala Phe Gly 
                805                 810                 815     


Glu Leu Gly Pro Arg Gly Lys Pro Gly Gln Lys Gly Tyr Ala Gly Glu 
            820                 825                 830         


Pro Gly Pro Glu Gly Leu Lys Gly Glu Val Gly Asp Gln Gly Asn Ile 
        835                 840                 845             


Gly Lys Ile Gly Glu Thr Gly Pro Val Gly Leu Pro Gly Glu Val Gly 
    850                 855                 860                 


Met Thr Gly Ser Ile Gly Glu Lys Gly Glu Arg Gly Ser Pro Gly Pro 
865                 870                 875                 880 


Leu Gly Pro Gln Gly Glu Lys Gly Val Met Gly Tyr Pro Gly Pro Pro 
                885                 890                 895     


Gly Val Pro Gly Pro Ile Gly Pro Leu Gly Leu Pro Gly His Val Gly 
            900                 905                 910         


Ala Arg Gly Pro Pro Gly Ser Gln Gly Pro Lys Gly Gln Arg Gly Ser 
        915                 920                 925             


Arg Gly Pro Asp Gly Leu Leu Gly Glu Gln Gly Ile Gln Gly Ala Lys 
    930                 935                 940                 


Gly Glu Lys Gly Asp Gln Gly Lys Arg Gly Pro His Gly Leu Ile Gly 
945                 950                 955                 960 


Lys Thr Gly Asn Pro Gly Glu Arg Gly Phe Gln Gly Lys Pro Gly Leu 
                965                 970                 975     


Gln Gly Leu Pro Gly Ser Thr Gly Asp Arg Gly Leu Pro Gly Glu Pro 
            980                 985                 990         


Gly Leu Arg Gly Leu Gln Gly Asp  Val Gly Pro Pro Gly  Glu Met Gly 
        995                 1000                 1005             


Met Glu  Gly Pro Pro Gly Thr  Glu Gly Glu Ser Gly  Leu Gln Gly 
    1010                 1015                 1020             


Glu Pro  Gly Ala Lys Gly Asp  Val Gly Thr Ala Gly  Ser Val Gly 
    1025                 1030                 1035             


Gly Thr  Gly Glu Pro Gly Leu  Arg Gly Glu Pro Gly  Ala Pro Gly 
    1040                 1045                 1050             


Glu Glu  Gly Leu Gln Gly Lys  Asp Gly Leu Lys Gly  Val Pro Gly 
    1055                 1060                 1065             


Gly Arg  Gly Leu Pro Gly Glu  Asp Gly Glu Lys Gly  Glu Met Gly 
    1070                 1075                 1080             


Leu Pro  Gly Ile Ile Gly Pro  Leu Gly Arg Ser Gly  Gln Thr Gly 
    1085                 1090                 1095             


Leu Pro  Gly Pro Glu Gly Ile  Val Gly Ile Pro Gly  Gln Arg Gly 
    1100                 1105                 1110             


Arg Pro  Gly Lys Lys Gly Asp  Lys Gly Gln Ile Gly  Pro Thr Gly 
    1115                 1120                 1125             


Glu Val  Gly Ser Arg Gly Pro  Pro Gly Lys Ile Gly  Lys Ser Gly 
    1130                 1135                 1140             


Pro Lys  Gly Ala Arg Gly Thr  Arg Gly Ala Val Gly  His Leu Gly 
    1145                 1150                 1155             


Leu Met  Gly Pro Asp Gly Glu  Pro Gly Ile Pro Gly  Tyr Arg Gly 
    1160                 1165                 1170             


His Gln  Gly Gln Pro Gly Pro  Ser Gly Leu Pro Gly  Pro Lys Gly 
    1175                 1180                 1185             


Glu Lys  Gly Tyr Pro Gly Glu  Asp Ser Thr Val Leu  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Arg Gly Glu Pro Gly  Pro Val Gly Asp Gln  Gly Glu Arg 
    1205                 1210                 1215             


Gly Glu  Pro Gly Ala Glu Gly  Tyr Lys Gly His Val  Gly Val Pro 
    1220                 1225                 1230             


Gly Leu  Arg Gly Ala Thr Gly  Gln Gln Gly Pro Pro  Gly Glu Pro 
    1235                 1240                 1245             


Gly Asp  Gln Gly Glu Gln Gly  Leu Lys Gly Glu Arg  Gly Ser Glu 
    1250                 1255                 1260             


Gly Asn  Lys Gly Lys Lys Gly  Ala Pro Gly Pro Ser  Gly Lys Pro 
    1265                 1270                 1275             


Gly Ile  Pro Gly Leu Gln Gly  Leu Leu Gly Pro Lys  Gly Ile Gln 
    1280                 1285                 1290             


Gly Tyr  His Gly Ala Asp Gly  Ile Ser Gly Asn Pro  Gly Lys Ile 
    1295                 1300                 1305             


Gly Pro  Pro Gly Lys Gln Gly  Leu Pro Gly Ile Arg  Gly Gly Pro 
    1310                 1315                 1320             


Gly Arg  Thr Gly Leu Ala Gly  Ala Pro Gly Pro Pro  Gly Val Lys 
    1325                 1330                 1335             


Gly Ser  Ser Gly Leu Pro Gly  Ser Pro Gly Ile Gln  Gly Pro Lys 
    1340                 1345                 1350             


Gly Glu  Gln Gly Leu Pro Gly  Gln Pro Gly Ile Gln  Gly Lys Arg 
    1355                 1360                 1365             


Gly His  Arg Gly Ala Gln Gly  Asp Gln Gly Pro Cys  Gly Asp Pro 
    1370                 1375                 1380             


Gly Leu  Lys Gly Gln Pro Gly  Glu Tyr Gly Val Gln  Gly Leu Thr 
    1385                 1390                 1395             


Gly Phe  Gln Gly Phe Pro Gly  Pro Lys Gly Pro Glu  Gly Asp Ala 
    1400                 1405                 1410             


Gly Ile  Val Gly Ile Ser Gly  Pro Lys Gly Pro Ile  Gly His Arg 
    1415                 1420                 1425             


Gly Asn  Thr Gly Pro Leu Gly  Arg Glu Gly Ile Ile  Gly Pro Thr 
    1430                 1435                 1440             


Gly Arg  Thr Gly Pro Arg Gly  Glu Lys Gly Phe Arg  Gly Glu Thr 
    1445                 1450                 1455             


Gly Pro  Gln Gly Pro Arg Gly  Gln Pro Gly Pro Pro  Gly Pro Pro 
    1460                 1465                 1470             


Gly Ala  Pro Gly Pro Arg Lys  Gln Met Asp Ile Asn  Ala Ala Ile 
    1475                 1480                 1485             


Gln Ala  Leu Ile Glu Ser Asn  Thr Ala Leu Gln Met  Glu Ser Tyr 
    1490                 1495                 1500             


Gln Asn  Thr Glu Val Thr Leu  Ile Asp His Ser Glu  Glu Ile Phe 
    1505                 1510                 1515             


Lys Thr  Leu Asn Tyr Leu Ser  Asn Leu Leu His Ser  Ile Lys Asn 
    1520                 1525                 1530             


Pro Leu  Gly Thr Arg Asp Asn  Pro Ala Arg Ile Cys  Lys Asp Leu 
    1535                 1540                 1545             


Leu Asn  Cys Glu Gln Lys Val  Ser Asp Gly Lys Tyr  Trp Ile Asp 
    1550                 1555                 1560             


Pro Asn  Leu Gly Cys Pro Ser  Asp Ala Ile Glu Val  Phe Cys Asn 
    1565                 1570                 1575             


Phe Ser  Ala Gly Gly Gln Thr  Cys Leu Pro Pro Val  Ser Val Thr 
    1580                 1585                 1590             


Lys Leu  Glu Phe Gly Val Gly  Lys Val Gln Met Asn  Phe Leu His 
    1595                 1600                 1605             


Leu Leu  Ser Ser Glu Ala Thr  His Ile Ile Thr Ile  His Cys Leu 
    1610                 1615                 1620             


Asn Thr  Pro Arg Trp Thr Ser  Thr Gln Thr Ser Gly  Pro Gly Leu 
    1625                 1630                 1635             


Pro Ile  Gly Phe Lys Gly Trp  Asn Gly Gln Ile Phe  Lys Val Asn 
    1640                 1645                 1650             


Thr Leu  Leu Glu Pro Lys Val  Leu Ser Asp Asp Cys  Lys Ile Gln 
    1655                 1660                 1665             


Asp Gly  Ser Trp His Lys Ala  Thr Phe Leu Phe His  Thr Gln Glu 
    1670                 1675                 1680             


Pro Asn  Gln Leu Pro Val Ile  Glu Val Gln Lys Leu  Pro His Leu 
    1685                 1690                 1695             


Lys Thr  Glu Arg Lys Tyr Tyr  Ile Asp Ser Ser Ser  Val Cys Phe 
    1700                 1705                 1710             


Leu 
    


<210>  13
<211>  51
<212>  DNA
<213>  Gaussia princeps


<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  Signal peptide of gaussia luciferase

<400>  13
atgggagtga aagttctttt tgcccttatt tgtattgctg tggccgaggc c                51


<210>  14
<211>  45
<212>  DNA
<213>  Unknown

<220>
<223>  Forward primer for mutagenesis of N1365A of PICP

<400>  14
atgtccaccg aggcctccca ggccatcacc taccactgca agaac                       45


<210>  15
<211>  45
<212>  DNA
<213>  Unknown

<220>
<223>  Reverse primer for mutagenesis of N1365A of PICP

<400>  15
gttcttgcag tggtaggtga tggcctggga ggcctcggtg gacat                       45


