                         SEQUENCE LISTING

<110>  University College Cardiff Consultants Limited
       Harding, Keith
       Jiang, Wenguo
 
<120>  Molecular Targets for Healing or Treating Wounds

<130>  0050P/WO MYIP2010050

<150>  GB 1103898.1
<151>  2011-03-08

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  1
ctgcagagtg agttacacag cctgatgagt ccgtgagga                              39


<210>  2
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  2
actagtgaca aaaactgacc aggatttgta tttcgtcctc acggact                     47


<210>  3
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  3
ctgcaggatg ataggaccat cgccaatctg atgagtccgt gagga                       45


<210>  4
<211>  46
<212>  DNA
<213>  Homo sapiens

<400>  4
actagtgatc caactaaatg ccaactcgat ttcgtcctca cggact                      46


<210>  5
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  5
ctgcagtttg ctctttttta caattaatat ctgatgagtc cgtgagga                    48


<210>  6
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  6
actagttcat cctccttctc ctagttgttt cgtcctcacg gact                        44


<210>  7
<211>  74
<212>  DNA
<213>  Homo sapiens

<400>  7
ctgcagagtg agttacacag cctgatgagt ccgtgaggac gaaatacaaa tcctggtcag       60

tttttgttac tagt                                                         74


<210>  8
<211>  79
<212>  DNA
<213>  Homo sapiens

<400>  8
ctgcaggatg ataggaccat cgccaatctg atgagtccgt gaggacgaaa tcgagttggc       60

atttagttgg atcactagt                                                    79


<210>  9
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  9
ctgcagtttg ctctttttta caattaatat ctgatgagtc cgtgaggacg aaacaactag       60

gagaaggagg atgaactagt                                                   80


<210>  10
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  10
aattacaatt gatggggaga                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  11
ccacttttcc acctgaagta                                                   20


<210>  12
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  12
actgaacctg accgtacaca tattgtgtga cgatgaaagc                             40


<210>  13
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  13
gcgagtcaag ttatcaaacc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  14
tgtagctgtc cataagagca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  15
gcgagtcaag ttatcaaacc                                                   20


<210>  16
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  16
actgaacctg accgtacaca ctctttcagc catgtctagc                             40


<210>  17
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  17
taatacgact cactataggg                                                   20


<210>  18
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  18
tagaaggcac agtcgagg                                                     18


<210>  19
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  19
ctgatgagtc cgtgaggacg aa                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  20
ttcgtcctca cggactcatc ag                                                22


<210>  21
<211>  4320
<212>  DNA
<213>  Homo sapiens

<400>  21
atggatacga ctgcggcggc ggcgctgcct gcttttgtgg cgctcttgct cctctctcct       60

tggcctctcc tgggatcggc ccaaggccag ttctccgcag gtggctgtac ttttgatgat      120

ggtccagggg cctgtgatta ccaccaggat ctgtatgatg actttgaatg ggtgcatgtt      180

agtgctcaag agcctcatta tctaccaccc gagatgcccc aaggttccta tatgatagtg      240

gactcttcag atcacgaccc tggagaaaaa gccagacttc agctgcctac aatgaaggag      300

aacgacactc actgcattga tttcagttac ctattatata gccagaaagg actgaatcct      360

ggcactttga acatattagt tagggtgaat aaaggacctc ttgccaatcc aatttggaat      420

gtgactggat tcacgggtag agattggctt cgggctgagc tagcagtgag ctccttttgg      480

cccaatgaat atcaggtaat atttgaagct gaagtctcag gagggagaag tggttatatt      540

gccattgatg acatccaagt actgagttat ccttgtgata aatctcctca tttcctccgt      600

ctaggggatg tagaggtgaa tgcagggcaa aacgctacat ttcagtgcat tgccacaggg      660

agagatgctg tgcataacaa gttatggctc cagagacgaa atggagaaga tataccagta      720

gcccagacta agaacatcaa tcatagaagg tttgccgctt ccttcagatt gcaagaagtg      780

acaaaaactg accaggattt gtatcgctgt gtaactcagt cagaacgagg ttccggtgtg      840

tccaattttg ctcaacttat tgtgagagaa ccgccaagac ccattgctcc tcctcagctt      900

cttggtgttg ggcctacata tttgctgatc caactaaatg ccaactcgat cattggcgat      960

ggtcctatca tcctgaaaga agtagagtac cgaatgacat caggatcctg gacagaaacc     1020

catgcagtca atgctccaac ttacaaatta tggcatttag atccagatac cgaatatgag     1080

atccgagttc tacttacaag acctggtgaa ggtggaacgg ggctcccagg acctccacta     1140

atcaccagaa caaaatgtgc agaacctatg agaaccccaa agacattaaa gattgctgaa     1200

atacaggcaa gacggattgc tgtggactgg gaatccttgg gttacaacat tacgcgttgc     1260

cacactttta atgtcactat ctgctaccat tacttccgtg gtcacaacga gagcaaggca     1320

gactgtttgg acatggaccc caaagcccct cagcatgttg tgaaccatct gccaccttat     1380

acaaatgtca gcctcaagat gatcctaacc aatccagagg gaaggaagga gagtgaagag     1440

acaattattc aaactgatga agatgtgcct ggtcccgtac cagtaaaatc tcttcaagga     1500

acatcctttg aaaataagat cttcttgaac tggaaagaac ctttggatcc aaatggaatc     1560

atcactcaat atgagatcag ctatagcagt ataagatcat ttgatcctgc agtcccagtg     1620

gctggacctc cccagactgt atcaaattta tggaacagta cacaccatgt ctttatgcat     1680

ctccaccctg gaaccacgta ccagtttttc ataagagcca gcacggtcaa aggctttggt     1740

ccagccacag ccatcaatgt caccaccaat atctcagctc caactttacc tgactatgaa     1800

ggagttgatg cctctctcaa tgaaactgcc accacaataa ctgtattgtt gagaccagca     1860

caagccaaag gtgctcctat cagtgcttat cagattgttg tggaagaact gcacccacac     1920

cgaaccaaga gagaagccgg agccatggaa tgctaccagg ttcctgtcac ataccaaaat     1980

gccatgagtg ggggtgcacc gtattacttt gctgcagaac tacccccggg aaacctacct     2040

gagcctgccc cgttcactgt gggtgacaat cggacctacc aaggcttttg gaaccctcct     2100

ttggctccgc gcaaaggata caacatctat ttccaggcga tgagcagtgt ggagaaggaa     2160

actaaaaccc agtgcgtacg cattgctaca aaagcagcaa cagaagaacc agaagtgatc     2220

ccagatcccg ccaagcagac agacagagtg gtgaaaatag caggaattag tgctggaatt     2280

ttggtgttca tcctccttct cctagttgtc atattaattg taaaaaagag caaacttgct     2340

aaaaaacgca aagatgccat ggggaatacc cggcaggaga tgactcacat ggtgaatgca     2400

atggatcgaa gttatgctga tcagagcact ctgcatgcag aagatcctct ttccatcacc     2460

ttcatggacc aacataactt tagtccaaga tatgagaacc acagtgctac agcagagtcc     2520

agtcgccttc tagacgtacc tcgctacctc tgtgagggga cggaatcccc ttaccagaca     2580

ggacagctgc atccagccat cagggtagct gatttactgc agcacattaa tctcatgaag     2640

acatcagaca gctatgggtt caaagaggaa tatgagagct tttttgaagg acagtcagca     2700

tcttgggatg tagctaaaaa agatcaaaat agagcaaaaa accgatatgg aaacattata     2760

gcatatgatc actccagagt gattttgcaa cccgtagagg atgatccttc ctcagattat     2820

attaatgcca actatattga tggctaccag agaccaagtc attacattgc aacccaaggt     2880

cccgttcatg aaacagtgta tgatttctgg aggatgattt ggcaagaaca atctgcttgc     2940

attgtgatgg ttacaaattt agttgaggtt ggccgggtta aatgctataa atattggcct     3000

gatgatactg aagtttatgg tgacttcaaa gtaacgtgtg tagaaatgga accacttgct     3060

gaatatgtag ttaggacatt caccctggaa aggagggggt acaatgaaat ccgtgaagtt     3120

aaacagttcc atttcacggg ctggcctgac catggagtgc cctaccatgc tacagggctg     3180

ctttccttta tccggcgagt caagttatca aaccctccca gtgctggccc catcgttgta     3240

cattgcagtg ctggtgctgg acgaactggc tgctacattg tgattgacat catgctagac     3300

atggctgaaa gagagggtgt tgttgatatt tacaattgtg tcaaagcctt aagatctcgg     3360

cgtattaata tggtccagac agaggaacag tacattttta ttcatgatgc cattttagaa     3420

gcctgcttat gtggagaaac tgccatacct gtctgtgaat ttaaagctgc atattttgat     3480

atgattagaa tagactccca gactaactct tcacatctca aggatgaatt tcagactctg     3540

aattcagtca cccctcgact acaagctgaa gactgcagta tagcgtgcct gccaaggaac     3600

catgacaaga accgtttcat ggacatgctg ccacctgaca gatgtctgcc ttttttaatt     3660

acaattgatg gggagagcag taactacatc aatgctgctc ttatggacag ctacaggcaa     3720

ccagctgctt tcatcgtcac acaataccct ctgccaaaca ctgtaaaaga cttctggaga     3780

ttagtgtatg attatggctg tacctccatt gtgatgttaa acgaagtcga cttgtcccag     3840

ggctgccctc agtactggcc agaggaaggg atgctacgat atggccccat ccaagtggaa     3900

tgtatgtctt gttcaatgga ctgtgatgtg atcaaccgga tttttaggat atgcaatcta     3960

acaagaccac aggaaggtta tctgatggtg caacagtttc agtacctagg atgggcttct     4020

catcgagaag tgcctggatc caaaaggtca ttcttgaaac tgatacttca ggtggaaaag     4080

tggcaggagg aatgcgagga aggggaaggc cggacgatta tccactgcct aaatggtggc     4140

gggcgaagtg gcatgttctg tgctataggc atcgttgttg aaatggtgaa acggcaaaat     4200

gttgtcgatg ttttccatgc agtaaagaca ctgaggaaca gcaagccaaa catggtggaa     4260

gccccggagc aataccgttt ctgctatgat gtagctttgg agtacctgga atcatcttag     4320


<210>  22
<211>  1428
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Thr Thr Ala Ala Ala Ala Leu Pro Ala Phe Val Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Pro Trp Pro Leu Leu Gly Ser Ala Gln Gly Gln Phe Ser 
            20                  25                  30          


Ala Gly Gly Cys Thr Phe Asp Asp Gly Pro Gly Ala Cys Asp Tyr His 
        35                  40                  45              


Gln Asp Leu Tyr Asp Asp Phe Glu Trp Val His Val Ser Ala Gln Glu 
    50                  55                  60                  


Pro His Tyr Leu Pro Pro Glu Met Pro Gln Gly Ser Tyr Met Ile Val 
65                  70                  75                  80  


Asp Ser Ser Asp His Asp Pro Gly Glu Lys Ala Arg Leu Gln Leu Pro 
                85                  90                  95      


Thr Met Lys Glu Asn Asp Thr His Cys Ile Asp Phe Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Ser Gln Lys Gly Leu Asn Pro Gly Thr Leu Asn Ile Leu Val Val 
        115                 120                 125             


Asn Lys Gly Pro Leu Ala Asn Pro Ile Trp Asn Val Thr Gly Phe Thr 
    130                 135                 140                 


Gly Arg Asp Trp Leu Arg Ala Glu Leu Ala Val Ser Ser Phe Trp Pro 
145                 150                 155                 160 


Asn Glu Tyr Gln Val Ile Phe Glu Ala Glu Val Ser Gly Gly Arg Ser 
                165                 170                 175     


Gly Tyr Ile Ala Ile Asp Asp Ile Gln Val Leu Ser Tyr Pro Cys Asp 
            180                 185                 190         


Lys Ser Pro His Phe Leu Arg Leu Gly Asp Val Glu Val Asn Ala Gly 
        195                 200                 205             


Gln Asn Ala Thr Phe Gln Cys Ile Ala Thr Gly Arg Asp Ala Val His 
    210                 215                 220                 


Asn Lys Leu Trp Leu Gln Arg Arg Asn Gly Glu Asp Ile Pro Val Ala 
225                 230                 235                 240 


Gln Thr Lys Asn Ile Asn His Arg Arg Phe Ala Ala Ser Phe Leu Gln 
                245                 250                 255     


Glu Val Thr Lys Thr Asp Gln Asp Leu Tyr Arg Cys Val Thr Gln Ser 
            260                 265                 270         


Glu Arg Gly Ser Gly Val Ser Asn Phe Ala Gln Leu Ile Val Arg Glu 
        275                 280                 285             


Pro Pro Arg Pro Ile Ala Pro Pro Gln Leu Leu Gly Val Gly Pro Thr 
    290                 295                 300                 


Tyr Leu Leu Ile Gln Leu Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro 
305                 310                 315                 320 


Ile Ile Leu Lys Glu Val Glu Tyr Arg Met Thr Ser Gly Ser Trp Thr 
                325                 330                 335     


Glu Thr His Ala Val Asn Ala Pro Thr Tyr Lys Leu Trp His Leu Asp 
            340                 345                 350         


Pro Asp Thr Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu 
        355                 360                 365             


Gly Gly Thr Gly Leu Pro Gly Pro Pro Leu Ile Thr Arg Lys Cys Ala 
    370                 375                 380                 


Glu Pro Met Arg Thr Pro Lys Thr Leu Lys Ile Ala Glu Ile Gln Ala 
385                 390                 395                 400 


Arg Arg Ile Ala Val Asp Trp Glu Ser Leu Gly Tyr Asn Ile Thr Arg 
                405                 410                 415     


Cys His Thr Phe Asn Val Thr Ile Cys Tyr His Tyr Phe Arg Gly His 
            420                 425                 430         


Asn Glu Ser Lys Ala Asp Cys Leu Asp Met Asp Pro Lys Ala Pro Gln 
        435                 440                 445             


His Val Val Asn His Leu Pro Pro Tyr Thr Asn Val Ser Leu Lys Met 
    450                 455                 460                 


Ile Leu Thr Asn Pro Glu Gly Arg Lys Glu Ser Glu Glu Thr Ile Ile 
465                 470                 475                 480 


Gln Thr Asp Glu Asp Val Pro Gly Pro Val Pro Val Lys Ser Leu Gln 
                485                 490                 495     


Gly Thr Ser Phe Glu Asn Lys Ile Phe Leu Asn Trp Glu Pro Leu Asp 
            500                 505                 510         


Pro Asn Gly Ile Ile Thr Gln Tyr Glu Ile Ser Tyr Ser Ser Ile Arg 
        515                 520                 525             


Ser Phe Asp Pro Ala Val Pro Val Ala Gly Pro Pro Gln Thr Val Ser 
    530                 535                 540                 


Asn Leu Trp Asn Ser Thr His His Val Phe Met His Leu His Pro Gly 
545                 550                 555                 560 


Thr Thr Tyr Gln Phe Phe Ile Arg Ala Ser Thr Val Lys Gly Phe Gly 
                565                 570                 575     


Pro Ala Thr Ala Ile Asn Val Thr Thr Asn Ile Ser Ala Pro Thr Leu 
            580                 585                 590         


Pro Asp Tyr Glu Gly Val Asp Ala Ser Leu Asn Glu Thr Ala Thr Thr 
        595                 600                 605             


Ile Thr Val Leu Leu Arg Pro Ala Gln Ala Lys Gly Ala Pro Ile Ser 
    610                 615                 620                 


Ala Tyr Gln Ile Val Val Glu Glu Leu His Pro Arg Thr Lys Arg Glu 
625                 630                 635                 640 


Ala Gly Ala Met Glu Cys Tyr Gln Val Pro Val Thr Tyr Gln Asn Ala 
                645                 650                 655     


Met Ser Gly Gly Ala Pro Tyr Tyr Phe Ala Ala Glu Leu Pro Pro Gly 
            660                 665                 670         


Asn Leu Pro Glu Pro Ala Pro Phe Thr Val Gly Asp Asn Arg Thr Tyr 
        675                 680                 685             


Gln Gly Phe Trp Asn Pro Pro Leu Ala Pro Arg Lys Gly Tyr Asn Ile 
    690                 695                 700                 


Tyr Phe Gln Ala Met Ser Ser Val Glu Lys Glu Thr Lys Thr Gln Cys 
705                 710                 715                 720 


Val Arg Ile Ala Thr Lys Ala Ala Thr Glu Glu Pro Glu Val Ile Pro 
                725                 730                 735     


Asp Pro Ala Lys Gln Thr Asp Arg Val Val Lys Ile Ala Gly Ile Ser 
            740                 745                 750         


Ala Gly Ile Leu Val Phe Ile Leu Leu Leu Val Val Ile Leu Ile Val 
        755                 760                 765             


Lys Lys Ser Lys Leu Ala Lys Lys Arg Lys Asp Ala Met Gly Asn Thr 
    770                 775                 780                 


Arg Gln Glu Met Thr His Met Val Asn Ala Met Asp Arg Ser Tyr Ala 
785                 790                 795                 800 


Asp Gln Ser Thr Leu His Ala Glu Asp Pro Leu Ser Ile Thr Phe Met 
                805                 810                 815     


Asp Gln His Asn Phe Ser Pro Arg Tyr Glu Asn His Ser Ala Thr Ala 
            820                 825                 830         


Glu Ser Ser Arg Leu Leu Asp Val Pro Arg Tyr Leu Cys Glu Gly Thr 
        835                 840                 845             


Glu Ser Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile Arg Val Ala 
    850                 855                 860                 


Asp Leu Leu Gln His Ile Asn Leu Met Lys Thr Ser Asp Ser Tyr Gly 
865                 870                 875                 880 


Phe Lys Glu Glu Tyr Glu Ser Phe Phe Gly Gln Ser Ala Ser Trp Asp 
                885                 890                 895     


Val Ala Lys Lys Asp Gln Asn Arg Ala Lys Asn Arg Tyr Gly Asn Ile 
            900                 905                 910         


Ile Ala Tyr Asp His Ser Arg Val Ile Leu Gln Pro Val Glu Asp Asp 
        915                 920                 925             


Pro Ser Ser Asp Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr Gln Arg 
    930                 935                 940                 


Pro Ser His Tyr Ile Ala Thr Gln Gly Pro Val His Glu Thr Val Tyr 
945                 950                 955                 960 


Asp Phe Trp Arg Met Ile Trp Gln Glu Gln Ser Ala Cys Ile Val Met 
                965                 970                 975     


Val Thr Asn Leu Val Glu Val Gly Arg Val Lys Cys Tyr Lys Tyr Trp 
            980                 985                 990         


Pro Asp Asp Thr Glu Val Tyr Gly  Asp Phe Lys Val Thr  Cys Val Glu 
        995                 1000                 1005             


Met Glu  Pro Leu Ala Glu Tyr  Val Arg Thr Phe Thr  Leu Glu Arg 
    1010                 1015                 1020             


Arg Gly  Tyr Asn Glu Ile Arg  Glu Val Lys Gln Phe  His Phe Thr 
    1025                 1030                 1035             


Gly Trp  Pro Asp His Gly Val  Pro Tyr His Ala Thr  Gly Leu Leu 
    1040                 1045                 1050             


Ser Phe  Ile Arg Arg Val Lys  Leu Ser Asn Pro Pro  Ser Ala Gly 
    1055                 1060                 1065             


Pro Ile  Val Val His Cys Ser  Ala Gly Ala Gly Arg  Thr Gly Cys 
    1070                 1075                 1080             


Tyr Ile  Val Ile Asp Ile Met  Leu Asp Met Ala Glu  Arg Glu Gly 
    1085                 1090                 1095             


Val Val  Asp Ile Tyr Asn Cys  Val Lys Ala Leu Arg  Ser Arg Arg 
    1100                 1105                 1110             


Ile Asn  Met Val Gln Thr Glu  Glu Gln Tyr Ile Phe  Ile His Asp 
    1115                 1120                 1125             


Ala Ile  Leu Glu Ala Cys Leu  Cys Gly Glu Thr Ala  Ile Pro Val 
    1130                 1135                 1140             


Glu Phe  Lys Ala Ala Tyr Phe  Asp Met Ile Arg Ile  Asp Ser Gln 
    1145                 1150                 1155             


Thr Asn  Ser Ser His Leu Lys  Asp Glu Phe Gln Thr  Leu Asn Ser 
    1160                 1165                 1170             


Val Thr  Pro Arg Leu Gln Ala  Glu Asp Cys Ser Ile  Ala Cys Leu 
    1175                 1180                 1185             


Pro Arg  Asn His Asp Lys Asn  Arg Phe Met Asp Met  Leu Pro Pro 
    1190                 1195                 1200             


Asp Arg  Cys Leu Pro Phe Leu  Ile Thr Ile Asp Gly  Glu Ser Ser 
    1205                 1210                 1215             


Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser Tyr Arg  Gln Pro Ala 
    1220                 1225                 1230             


Ala Phe  Ile Val Thr Gln Tyr  Pro Leu Pro Asn Thr  Val Lys Asp 
    1235                 1240                 1245             


Phe Trp  Arg Leu Val Tyr Asp  Tyr Gly Cys Thr Ser  Ile Val Met 
    1250                 1255                 1260             


Leu Asn  Glu Val Asp Leu Ser  Gly Cys Pro Gln Tyr  Trp Pro Glu 
    1265                 1270                 1275             


Glu Gly  Met Leu Arg Tyr Gly  Pro Ile Gln Val Glu  Cys Met Ser 
    1280                 1285                 1290             


Cys Ser  Met Asp Cys Asp Val  Ile Asn Arg Ile Phe  Arg Ile Cys 
    1295                 1300                 1305             


Asn Leu  Thr Arg Pro Gln Glu  Gly Tyr Leu Met Val  Gln Gln Phe 
    1310                 1315                 1320             


Gln Tyr  Leu Gly Trp Ala Ser  His Arg Glu Val Pro  Gly Ser Lys 
    1325                 1330                 1335             


Arg Ser  Phe Leu Lys Leu Ile  Leu Gln Val Glu Lys  Trp Gln Glu 
    1340                 1345                 1350             


Glu Cys  Glu Glu Gly Glu Gly  Arg Thr Ile Ile His  Cys Leu Asn 
    1355                 1360                 1365             


Gly Gly  Gly Arg Ser Gly Met  Phe Cys Ala Ile Gly  Ile Val Val 
    1370                 1375                 1380             


Glu Met  Val Lys Arg Gln Asn  Val Val Asp Val Phe  His Ala Lys 
    1385                 1390                 1395             


Thr Leu  Arg Asn Ser Lys Pro  Asn Met Val Glu Ala  Pro Glu Gln 
    1400                 1405                 1410             


Tyr Arg  Phe Cys Tyr Asp Val  Ala Leu Glu Tyr Leu  Glu Ser Ser 
    1415                 1420                 1425             


