                         SEQUENCE LISTING

<110>  Sloan Kettering Institute for Cancer Research
 
<120>  PARATHYROID HORMONE ANALOGS, COMPOSITIONS AND USES THEREOF

<130>  2003080-0394

<140>  61/448,064
<141>  2011-03-01

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser 
        35                  40                  45              


Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu 
    50                  55                  60                  


Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys 
65                  70                  75                  80  


Ala Lys Ser Gln 
                


<210>  2
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (41)..(43)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (45)..(48)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (58)..(64)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<400>  2

Xaa Val Ser Glu Ile Gln Xaa Xaa His Asn Leu Gly Lys His Leu Xaa 
1               5                   10                  15      


Ser Xaa Glu Arg Xaa Xaa Trp Leu Arg Xaa Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa Xaa Leu Gly Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa 
        35                  40                  45              


Gln Arg Pro Xaa Lys Lys Glu Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Lys Ser Leu Gly Glu Xaa Asp Lys Ala Xaa Val Xaa Val Leu Xaa Lys 
65                  70                  75                  80  


Xaa Lys Xaa Gln 
                


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<400>  3

Xaa His Asn Leu Gly Lys His Leu 
1               5               


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
1               5                   10          


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<400>  5

Xaa His Asn Leu Gly Lys His Leu Xaa Ser Xaa 
1               5                   10      


<210>  6
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<400>  6

Xaa Val Ser Glu Ile Gln Xaa Met His Asn Leu Gly Lys His Leu Xaa 
1               5                   10                  15      


Ser Met Glu Arg Xaa Xaa Trp Leu Arg Xaa Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  7
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<400>  7

Xaa Val Ser Glu Ile Gln Xaa Xaa His Asn Leu Gly Lys His Leu Xaa 
1               5                   10                  15      


Ser Xaa Glu Arg Xaa Xaa Trp Leu Arg Xaa Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  8
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys Pro 
        35                  40                  45              


Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp Glu 
    50                  55                  60                  


Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu 
65                  70                  75                  80  


Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys 
                85                  90                  95      


Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu 
            100                 105                 110         


Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp 
        115                 120                 125             


Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg Arg His 
    130                 135                 140     


<210>  9
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(26)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(32)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(56)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(77)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (85)..(86)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (112)..(113)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (115)..(129)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (131)..(140)
<223>  Xaa can be any naturally occurring or synthetic amino acid

<400>  9

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Xaa Phe Leu Xaa Xaa Leu Ile Xaa Xaa Xaa Xaa 
            20                  25                  30          


Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Xaa Lys Pro 
        35                  40                  45              


Xaa Xaa Asn Thr Lys Asn Xaa Xaa Val Arg Phe Gly Ser Xaa Asp Glu 
    50                  55                  60                  


Gly Xaa Tyr Leu Thr Gln Glu Thr Asn Lys Xaa Xaa Xaa Tyr Lys Glu 
65                  70                  75                  80  


Gln Pro Leu Lys Xaa Xaa Gly Lys Lys Lys Lys Xaa Lys Pro Gly Lys 
                85                  90                  95      


Arg Xaa Glu Gln Glu Lys Lys Lys Arg Arg Xaa Arg Ser Ala Trp Xaa 
            100                 105                 110         


Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His 
    130                 135                 140     


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln Asp Leu Arg Arg 
1               5                   10                  15      


Arg 
    


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn 
1               5                   10              


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Tyr Leu Thr Gln Glu Thr Asn Lys 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Glu Gln Glu Lys Lys Lys Arg Arg 
1               5               


<210>  14
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  15
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu 
        35          


<210>  16
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys Pro 
        35                  40                  45              


Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp Glu 
    50                  55                  60                  


Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu 
65                  70                  75                  80  


Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys 
                85                  90                  95      


Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu 
            100                 105                 110         


Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp 
        115                 120                 125             


Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg 
    130                 135                 


<210>  17
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys Pro 
        35                  40                  45              


Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp Glu 
    50                  55                  60                  


Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu 
65                  70                  75                  80  


Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys 
                85                  90                  95      


Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu 
            100                 105                 110         


Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp 
        115                 120                 125             


Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg Thr Ala Leu Leu Trp 
    130                 135                 140                 


Gly Leu Lys Lys Lys Lys Glu Asn Asn Arg Arg Thr His His Met Gln 
145                 150                 155                 160 


Leu Met Ile Ser Leu Phe Lys Ser Pro Leu Leu Leu Leu 
                165                 170             


<210>  18
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly Ala 
        35                  


