                         SEQUENCE LISTING

<110>  TRYGGVASON, KARL
       RODIN, SERGEY
 
<120>  ISOLATED LAMININ-421

<130>  LCTI 200005WO01

<150>  61/447818
<151>  2011-03-01

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1823
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser 
            260                 265                 270         


Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Ala Leu Arg Leu Ala Ala 
        275                 280                 285             


Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly 
    290                 295                 300                 


Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys 
                325                 330                 335     


Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp 
            340                 345                 350         


Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln 
        355                 360                 365             


Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu 
    370                 375                 380                 


Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn 
385                 390                 395                 400 


Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile 
                405                 410                 415     


Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser 
            420                 425                 430         


Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp 
        435                 440                 445             


Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His 
    450                 455                 460                 


Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp 
465                 470                 475                 480 


Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu 
                485                 490                 495     


Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg 
            500                 505                 510         


Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu 
        515                 520                 525             


Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro 
    530                 535                 540                 


Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly 
545                 550                 555                 560 


Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu 
                565                 570                 575     


Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp 
            580                 585                 590         


His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu 
        595                 600                 605             


His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser 
    610                 615                 620                 


Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr 
625                 630                 635                 640 


Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser 
                645                 650                 655     


Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu 
            660                 665                 670         


Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp 
        675                 680                 685             


Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg 
    690                 695                 700                 


Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln 
705                 710                 715                 720 


Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu 
                725                 730                 735     


Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr 
            740                 745                 750         


Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His 
        755                 760                 765             


Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala 
    770                 775                 780                 


Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg 
785                 790                 795                 800 


Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln 
                805                 810                 815     


Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile 
            820                 825                 830         


Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser 
        835                 840                 845             


Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr 
    850                 855                 860                 


Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln 
865                 870                 875                 880 


Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly 
                885                 890                 895     


Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr 
            900                 905                 910         


Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro 
        915                 920                 925             


Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys 
    930                 935                 940                 


Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe 
945                 950                 955                 960 


Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp 
                965                 970                 975     


Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys 
            980                 985                 990         


Leu Pro Thr Ser Leu Asn Leu Pro  Gly Phe Val Gly Cys  Leu Glu Leu 
        995                 1000                 1005             


Ala Thr  Leu Asn Asn Asp Val  Ile Ser Leu Tyr Asn  Phe Lys His 
    1010                 1015                 1020             


Ile Tyr  Asn Met Asp Pro Ser  Thr Ser Val Pro Cys  Ala Arg Asp 
    1025                 1030                 1035             


Lys Leu  Ala Phe Thr Gln Ser  Arg Ala Ala Ser Tyr  Phe Phe Asp 
    1040                 1045                 1050             


Gly Ser  Gly Tyr Ala Val Val  Arg Asp Ile Thr Arg  Arg Gly Lys 
    1055                 1060                 1065             


Phe Gly  Gln Val Thr Arg Phe  Asp Ile Glu Val Arg  Thr Pro Ala 
    1070                 1075                 1080             


Asp Asn  Gly Leu Ile Leu Leu  Met Val Asn Gly Ser  Met Phe Phe 
    1085                 1090                 1095             


Arg Leu  Glu Met Arg Asn Gly  Tyr Leu His Val Phe  Tyr Asp Phe 
    1100                 1105                 1110             


Gly Phe  Ser Gly Gly Pro Val  His Leu Glu Asp Thr  Leu Lys Lys 
    1115                 1120                 1125             


Ala Gln  Ile Asn Asp Ala Lys  Tyr His Glu Ile Ser  Ile Ile Tyr 
    1130                 1135                 1140             


His Asn  Asp Lys Lys Met Ile  Leu Val Val Asp Arg  Arg His Val 
    1145                 1150                 1155             


Lys Ser  Met Asp Asn Glu Lys  Met Lys Ile Pro Phe  Thr Asp Ile 
    1160                 1165                 1170             


Tyr Ile  Gly Gly Ala Pro Pro  Glu Ile Leu Gln Ser  Arg Ala Leu 
    1175                 1180                 1185             


Arg Ala  His Leu Pro Leu Asp  Ile Asn Phe Arg Gly  Cys Met Lys 
    1190                 1195                 1200             


Gly Phe  Gln Phe Gln Lys Lys  Asp Phe Asn Leu Leu  Glu Gln Thr 
    1205                 1210                 1215             


Glu Thr  Leu Gly Val Gly Tyr  Gly Cys Pro Glu Asp  Ser Leu Ile 
    1220                 1225                 1230             


Ser Arg  Arg Ala Tyr Phe Asn  Gly Gln Ser Phe Ile  Ala Ser Ile 
    1235                 1240                 1245             


Gln Lys  Ile Ser Phe Phe Asp  Gly Phe Glu Gly Gly  Phe Asn Phe 
    1250                 1255                 1260             


Arg Thr  Leu Gln Pro Asn Gly  Leu Leu Phe Tyr Tyr  Ala Ser Gly 
    1265                 1270                 1275             


Ser Asp  Val Phe Ser Ile Ser  Leu Asp Asn Gly Thr  Val Ile Met 
    1280                 1285                 1290             


Asp Val  Lys Gly Ile Lys Val  Gln Ser Val Asp Lys  Gln Tyr Asn 
    1295                 1300                 1305             


Asp Gly  Leu Ser His Phe Val  Ile Ser Ser Val Ser  Pro Thr Arg 
    1310                 1315                 1320             


Tyr Glu  Leu Ile Val Asp Lys  Ser Arg Val Gly Ser  Lys Asn Pro 
    1325                 1330                 1335             


Thr Lys  Gly Lys Ile Glu Gln  Thr Gln Ala Ser Glu  Lys Lys Phe 
    1340                 1345                 1350             


Tyr Phe  Gly Gly Ser Pro Ile  Ser Ala Gln Tyr Ala  Asn Phe Thr 
    1355                 1360                 1365             


Gly Cys  Ile Ser Asn Ala Tyr  Phe Thr Arg Val Asp  Arg Asp Val 
    1370                 1375                 1380             


Glu Val  Glu Asp Phe Gln Arg  Tyr Thr Glu Lys Val  His Thr Ser 
    1385                 1390                 1395             


Leu Tyr  Glu Cys Pro Ile Glu  Ser Ser Pro Leu Phe  Leu Leu His 
    1400                 1405                 1410             


Lys Lys  Gly Lys Asn Leu Ser  Lys Pro Lys Ala Ser  Gln Asn Lys 
    1415                 1420                 1425             


Lys Gly  Gly Lys Ser Lys Asp  Ala Pro Ser Trp Asp  Pro Val Ala 
    1430                 1435                 1440             


Leu Lys  Leu Pro Glu Arg Asn  Thr Pro Arg Asn Ser  His Cys His 
    1445                 1450                 1455             


Leu Ser  Asn Ser Pro Arg Ala  Ile Glu His Ala Tyr  Gln Tyr Gly 
    1460                 1465                 1470             


Gly Thr  Ala Asn Ser Arg Gln  Glu Phe Glu His Leu  Lys Gly Asp 
    1475                 1480                 1485             


Phe Gly  Ala Lys Ser Gln Phe  Ser Ile Arg Leu Arg  Thr Arg Ser 
    1490                 1495                 1500             


Ser His  Gly Met Ile Phe Tyr  Val Ser Asp Gln Glu  Glu Asn Asp 
    1505                 1510                 1515             


Phe Met  Thr Leu Phe Leu Ala  His Gly Arg Leu Val  Tyr Met Phe 
    1520                 1525                 1530             


Asn Val  Gly His Lys Lys Leu  Lys Ile Arg Ser Gln  Glu Lys Tyr 
    1535                 1540                 1545             


Asn Asp  Gly Leu Trp His Asp  Val Ile Phe Ile Arg  Glu Arg Ser 
    1550                 1555                 1560             


Ser Gly  Arg Leu Val Ile Asp  Gly Leu Arg Val Leu  Glu Glu Ser 
    1565                 1570                 1575             


Leu Pro  Pro Thr Glu Ala Thr  Trp Lys Ile Lys Gly  Pro Ile Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Val Ala Pro Gly  Lys Ala Val Lys Asn  Val Gln Ile 
    1595                 1600                 1605             


Asn Ser  Ile Tyr Ser Phe Ser  Gly Cys Leu Ser Asn  Leu Gln Leu 
    1610                 1615                 1620             


Asn Gly  Ala Ser Ile Thr Ser  Ala Ser Gln Thr Phe  Ser Val Thr 
    1625                 1630                 1635             


Pro Cys  Phe Glu Gly Pro Met  Glu Thr Gly Thr Tyr  Phe Ser Thr 
    1640                 1645                 1650             


Glu Gly  Gly Tyr Val Val Leu  Asp Glu Ser Phe Asn  Ile Gly Leu 
    1655                 1660                 1665             


Lys Phe  Glu Ile Ala Phe Glu  Val Arg Pro Arg Ser  Ser Ser Gly 
    1670                 1675                 1680             


Thr Leu  Val His Gly His Ser  Val Asn Gly Glu Tyr  Leu Asn Val 
    1685                 1690                 1695             


His Met  Lys Asn Gly Gln Val  Ile Val Lys Val Asn  Asn Gly Ile 
    1700                 1705                 1710             


Arg Asp  Phe Ser Thr Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp 
    1715                 1720                 1725             


Gly Arg  Trp His Arg Ile Thr  Val Ile Arg Asp Ser  Asn Val Val 
    1730                 1735                 1740             


Gln Leu  Asp Val Asp Ser Glu  Val Asn His Val Val  Gly Pro Leu 
    1745                 1750                 1755             


Asn Pro  Lys Pro Ile Asp His  Arg Glu Pro Val Phe  Val Gly Gly 
    1760                 1765                 1770             


Val Pro  Glu Ser Leu Leu Thr  Pro Arg Leu Ala Pro  Ser Lys Pro 
    1775                 1780                 1785             


Phe Thr  Gly Cys Ile Arg His  Phe Val Ile Asp Gly  His Pro Val 
    1790                 1795                 1800             


Ser Phe  Ser Lys Ala Ala Leu  Val Ser Gly Ala Val  Ser Ile Asn 
    1805                 1810                 1815             


Ser Cys  Pro Ala Ala 
    1820             


<210>  2
<211>  1798
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Leu Thr Ser Arg Glu Arg Gly Arg Gly Gln Pro Leu Pro Trp 
1               5                   10                  15      


Glu Leu Arg Leu Gly Leu Leu Leu Ser Val Leu Ala Ala Thr Leu Ala 
            20                  25                  30          


Gln Ala Pro Ala Pro Asp Val Pro Gly Cys Ser Arg Gly Ser Cys Tyr 
        35                  40                  45              


Pro Ala Thr Gly Asp Leu Leu Val Gly Arg Ala Asp Arg Leu Thr Ala 
    50                  55                  60                  


Ser Ser Thr Cys Gly Leu Asn Gly Pro Gln Pro Tyr Cys Ile Val Ser 
65                  70                  75                  80  


His Leu Gln Asp Glu Lys Lys Cys Phe Leu Cys Asp Ser Arg Arg Pro 
                85                  90                  95      


Phe Ser Ala Arg Asp Asn Pro His Ser His Arg Ile Gln Asn Val Val 
            100                 105                 110         


Thr Ser Phe Ala Pro Gln Arg Arg Ala Ala Trp Trp Gln Ser Glu Asn 
        115                 120                 125             


Gly Ile Pro Ala Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His 
    130                 135                 140                 


Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met 
145                 150                 155                 160 


Leu Val Glu Arg Ser Ala Asp Phe Gly Arg Thr Trp His Val Tyr Arg 
                165                 170                 175     


Tyr Phe Ser Tyr Asp Cys Gly Ala Asp Phe Pro Gly Val Pro Leu Ala 
            180                 185                 190         


Pro Pro Arg His Trp Asp Asp Val Val Cys Glu Ser Arg Tyr Ser Glu 
        195                 200                 205             


Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Tyr Arg Val Leu Asp Pro 
    210                 215                 220                 


Ala Ile Pro Ile Pro Asp Pro Tyr Ser Ser Arg Ile Gln Asn Leu Leu 
225                 230                 235                 240 


Lys Ile Thr Asn Leu Arg Val Asn Leu Thr Arg Leu His Thr Leu Gly 
                245                 250                 255     


Asp Asn Leu Leu Asp Pro Arg Arg Glu Ile Arg Glu Lys Tyr Tyr Tyr 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His 
        275                 280                 285             


Ala Ser Glu Cys Ala Pro Ala Pro Gly Ala Pro Ala His Ala Glu Gly 
    290                 295                 300                 


Met Val His Gly Ala Cys Ile Cys Lys His Asn Thr Arg Gly Leu Asn 
305                 310                 315                 320 


Cys Glu Gln Cys Gln Asp Phe Tyr Arg Asp Leu Pro Trp Arg Pro Ala 
                325                 330                 335     


Glu Asp Gly His Ser His Ala Cys Arg Lys Cys Glu Cys His Gly His 
            340                 345                 350         


Thr His Ser Cys His Phe Asp Met Ala Val Tyr Leu Ala Ser Gly Asn 
        355                 360                 365             


Val Ser Gly Gly Val Cys Asp Gly Cys Gln His Asn Thr Ala Gly Arg 
    370                 375                 380                 


His Cys Glu Leu Cys Arg Pro Phe Phe Tyr Arg Asp Pro Thr Lys Asp 
385                 390                 395                 400 


Leu Arg Asp Pro Ala Val Cys Arg Ser Cys Asp Cys Asp Pro Met Gly 
                405                 410                 415     


Ser Gln Asp Gly Gly Arg Cys Asp Ser His Asp Asp Pro Ala Leu Gly 
            420                 425                 430         


Leu Val Ser Gly Gln Cys Arg Cys Lys Glu His Val Val Gly Thr Arg 
        435                 440                 445             


Cys Gln Gln Cys Arg Asp Gly Phe Phe Gly Leu Ser Ile Ser Asp Arg 
    450                 455                 460                 


Leu Gly Cys Arg Arg Cys Gln Cys Asn Ala Arg Gly Thr Val Pro Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asp Pro Asn Ser Gly Ser Cys Tyr Cys Lys Arg Leu 
                485                 490                 495     


Val Thr Gly Arg Gly Cys Asp Arg Cys Leu Pro Gly His Trp Gly Leu 
            500                 505                 510         


Ser His Asp Leu Leu Gly Cys Arg Pro Cys Asp Cys Asp Val Gly Gly 
        515                 520                 525             


Ala Leu Asp Pro Gln Cys Asp Glu Gly Thr Gly Gln Cys His Cys Arg 
    530                 535                 540                 


Gln His Met Val Gly Arg Arg Cys Glu Gln Val Gln Pro Gly Tyr Phe 
545                 550                 555                 560 


Arg Pro Phe Leu Asp His Leu Ile Trp Glu Ala Glu Asp Thr Arg Gly 
                565                 570                 575     


Gln Val Leu Asp Val Val Glu Arg Leu Val Thr Pro Gly Glu Thr Pro 
            580                 585                 590         


Ser Trp Thr Gly Ser Gly Phe Val Arg Leu Gln Glu Gly Gln Thr Leu 
        595                 600                 605             


Glu Phe Leu Val Ala Ser Val Pro Lys Ala Met Asp Tyr Asp Leu Leu 
    610                 615                 620                 


Leu Arg Leu Glu Pro Gln Val Pro Glu Gln Trp Ala Glu Leu Glu Leu 
625                 630                 635                 640 


Ile Val Gln Arg Pro Gly Pro Val Pro Ala His Ser Leu Cys Gly His 
                645                 650                 655     


Leu Val Pro Lys Asp Asp Arg Ile Gln Gly Thr Leu Gln Pro His Ala 
            660                 665                 670         


Arg Tyr Leu Ile Phe Pro Asn Pro Val Cys Leu Glu Pro Gly Ile Ser 
        675                 680                 685             


Tyr Lys Leu His Leu Lys Leu Val Arg Thr Gly Gly Ser Ala Gln Pro 
    690                 695                 700                 


Glu Thr Pro Tyr Ser Gly Pro Gly Leu Leu Ile Asp Ser Leu Val Leu 
705                 710                 715                 720 


Leu Pro Arg Val Leu Val Leu Glu Met Phe Ser Gly Gly Asp Ala Ala 
                725                 730                 735     


Ala Leu Glu Arg Gln Ala Thr Phe Glu Arg Tyr Gln Cys His Glu Glu 
            740                 745                 750         


Gly Leu Val Pro Ser Lys Thr Ser Pro Ser Glu Ala Cys Ala Pro Leu 
        755                 760                 765             


Leu Ile Ser Leu Ser Thr Leu Ile Tyr Asn Gly Ala Leu Pro Cys Gln 
    770                 775                 780                 


Cys Asn Pro Gln Gly Ser Leu Ser Ser Glu Cys Asn Pro His Gly Gly 
785                 790                 795                 800 


Gln Cys Leu Cys Lys Pro Gly Val Val Gly Arg Arg Cys Asp Leu Cys 
                805                 810                 815     


Ala Pro Gly Tyr Tyr Gly Phe Gly Pro Thr Gly Cys Gln Ala Cys Gln 
            820                 825                 830         


Cys Ser His Glu Gly Ala Leu Ser Ser Leu Cys Glu Lys Thr Ser Gly 
        835                 840                 845             


Gln Cys Leu Cys Arg Thr Gly Ala Phe Gly Leu Arg Cys Asp Arg Cys 
    850                 855                 860                 


Gln Arg Gly Gln Trp Gly Phe Pro Ser Cys Arg Pro Cys Val Cys Asn 
865                 870                 875                 880 


Gly His Ala Asp Glu Cys Asn Thr His Thr Gly Ala Cys Leu Gly Cys 
                885                 890                 895     


Arg Asp His Thr Gly Gly Glu His Cys Glu Arg Cys Ile Ala Gly Phe 
            900                 905                 910         


His Gly Asp Pro Arg Leu Pro Tyr Gly Gly Gln Cys Arg Pro Cys Pro 
        915                 920                 925             


Cys Pro Glu Gly Pro Gly Ser Gln Arg His Phe Ala Thr Ser Cys His 
    930                 935                 940                 


Gln Asp Glu Tyr Ser Gln Gln Ile Val Cys His Cys Arg Ala Gly Tyr 
945                 950                 955                 960 


Thr Gly Leu Arg Cys Glu Ala Cys Ala Pro Gly His Phe Gly Asp Pro 
                965                 970                 975     


Ser Arg Pro Gly Gly Arg Cys Gln Leu Cys Glu Cys Ser Gly Asn Ile 
            980                 985                 990         


Asp Pro Met Asp Pro Asp Ala Cys  Asp Pro His Thr Gly  Gln Cys Leu 
        995                 1000                 1005             


Arg Cys  Leu His His Thr Glu  Gly Pro His Cys Ala  His Cys Lys 
    1010                 1015                 1020             


Pro Gly  Phe His Gly Gln Ala  Ala Arg Gln Ser Cys  His Arg Cys 
    1025                 1030                 1035             


Thr Cys  Asn Leu Leu Gly Thr  Asn Pro Gln Gln Cys  Pro Ser Pro 
    1040                 1045                 1050             


Asp Gln  Cys His Cys Asp Pro  Ser Ser Gly Gln Cys  Pro Cys Leu 
    1055                 1060                 1065             


Pro Asn  Val Gln Gly Pro Ser  Cys Asp Arg Cys Ala  Pro Asn Phe 
    1070                 1075                 1080             


Trp Asn  Leu Thr Ser Gly His  Gly Cys Gln Pro Cys  Ala Cys His 
    1085                 1090                 1095             


Pro Ser  Arg Ala Arg Gly Pro  Thr Cys Asn Glu Phe  Thr Gly Gln 
    1100                 1105                 1110             


Cys His  Cys Arg Ala Gly Phe  Gly Gly Arg Thr Cys  Ser Glu Cys 
    1115                 1120                 1125             


Gln Glu  Leu His Trp Gly Asp  Pro Gly Leu Gln Cys  His Ala Cys 
    1130                 1135                 1140             


Asp Cys  Asp Ser Arg Gly Ile  Asp Thr Pro Gln Cys  His Arg Phe 
    1145                 1150                 1155             


Thr Gly  His Cys Ser Cys Arg  Pro Gly Val Ser Gly  Val Arg Cys 
    1160                 1165                 1170             


Asp Gln  Cys Ala Arg Gly Phe  Ser Gly Ile Phe Pro  Ala Cys His 
    1175                 1180                 1185             


Pro Cys  His Ala Cys Phe Gly  Asp Trp Asp Arg Val  Val Gln Asp 
    1190                 1195                 1200             


Leu Ala  Ala Arg Thr Gln Arg  Leu Glu Gln Arg Ala  Gln Glu Leu 
    1205                 1210                 1215             


Gln Gln  Thr Gly Val Leu Gly  Ala Phe Glu Ser Ser  Phe Trp His 
    1220                 1225                 1230             


Met Gln  Glu Lys Leu Gly Ile  Val Gln Gly Ile Val  Gly Ala Arg 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Ser Thr  Ala Gln Leu Val Glu  Ala Thr Glu 
    1250                 1255                 1260             


Glu Leu  Arg Arg Glu Ile Gly  Glu Ala Thr Glu His  Leu Thr Gln 
    1265                 1270                 1275             


Leu Glu  Ala Asp Leu Thr Asp  Val Gln Asp Glu Asn  Phe Asn Ala 
    1280                 1285                 1290             


Asn His  Ala Leu Ser Gly Leu  Glu Arg Asp Arg Leu  Ala Leu Asn 
    1295                 1300                 1305             


Leu Thr  Leu Arg Gln Leu Asp  Gln His Leu Asp Leu  Leu Lys His 
    1310                 1315                 1320             


Ser Asn  Phe Leu Gly Ala Tyr  Asp Ser Ile Arg His  Ala His Ser 
    1325                 1330                 1335             


Gln Ser  Ala Glu Ala Glu Arg  Arg Ala Asn Thr Ser  Ala Leu Ala 
    1340                 1345                 1350             


Val Pro  Ser Pro Val Ser Asn  Ser Ala Ser Ala Arg  His Arg Thr 
    1355                 1360                 1365             


Glu Ala  Leu Met Asp Ala Gln  Lys Glu Asp Phe Asn  Ser Lys His 
    1370                 1375                 1380             


Met Ala  Asn Gln Arg Ala Leu  Gly Lys Leu Ser Ala  His Thr His 
    1385                 1390                 1395             


Thr Leu  Ser Leu Thr Asp Ile  Asn Glu Leu Val Cys  Gly Ala Pro 
    1400                 1405                 1410             


Gly Asp  Ala Pro Cys Ala Thr  Ser Pro Cys Gly Gly  Ala Gly Cys 
    1415                 1420                 1425             


Arg Asp  Glu Asp Gly Gln Pro  Arg Cys Gly Gly Leu  Ser Cys Asn 
    1430                 1435                 1440             


Gly Ala  Ala Ala Thr Ala Asp  Leu Ala Leu Gly Arg  Ala Arg His 
    1445                 1450                 1455             


Thr Gln  Ala Glu Leu Gln Arg  Ala Leu Ala Glu Gly  Gly Ser Ile 
    1460                 1465                 1470             


Leu Ser  Arg Val Ala Glu Thr  Arg Arg Gln Ala Ser  Glu Ala Gln 
    1475                 1480                 1485             


Gln Arg  Ala Gln Ala Ala Leu  Asp Lys Ala Asn Ala  Ser Arg Gly 
    1490                 1495                 1500             


Gln Val  Glu Gln Ala Asn Gln  Glu Leu Gln Glu Leu  Ile Gln Ser 
    1505                 1510                 1515             


Val Lys  Asp Phe Leu Asn Gln  Glu Gly Ala Asp Pro  Asp Ser Ile 
    1520                 1525                 1530             


Glu Met  Val Ala Thr Arg Val  Leu Glu Leu Ser Ile  Pro Ala Ser 
    1535                 1540                 1545             


Ala Glu  Gln Ile Gln His Leu  Ala Gly Ala Ile Ala  Glu Arg Val 
    1550                 1555                 1560             


Arg Ser  Leu Ala Asp Val Asp  Ala Ile Leu Ala Arg  Thr Val Gly 
    1565                 1570                 1575             


Asp Val  Arg Arg Ala Glu Gln  Leu Leu Gln Asp Ala  Arg Arg Ala 
    1580                 1585                 1590             


Arg Ser  Trp Ala Glu Asp Glu  Lys Gln Lys Ala Glu  Thr Val Gln 
    1595                 1600                 1605             


Ala Ala  Leu Glu Glu Ala Gln  Arg Ala Gln Gly Ile  Ala Gln Gly 
    1610                 1615                 1620             


Ala Ile  Arg Gly Ala Val Ala  Asp Thr Arg Asp Thr  Glu Gln Thr 
    1625                 1630                 1635             


Leu Tyr  Gln Val Gln Glu Arg  Met Ala Gly Ala Glu  Arg Ala Leu 
    1640                 1645                 1650             


Ser Ser  Ala Gly Glu Arg Ala  Arg Gln Leu Asp Ala  Leu Leu Glu 
    1655                 1660                 1665             


Ala Leu  Lys Leu Lys Arg Ala  Gly Asn Ser Leu Ala  Ala Ser Thr 
    1670                 1675                 1680             


Ala Glu  Glu Thr Ala Gly Ser  Ala Gln Gly Arg Ala  Gln Glu Ala 
    1685                 1690                 1695             


Glu Gln  Leu Leu Arg Gly Pro  Leu Gly Asp Gln Tyr  Gln Thr Val 
    1700                 1705                 1710             


Lys Ala  Leu Ala Glu Arg Lys  Ala Gln Gly Val Leu  Ala Ala Gln 
    1715                 1720                 1725             


Ala Arg  Ala Glu Gln Leu Arg  Asp Glu Ala Arg Asp  Leu Leu Gln 
    1730                 1735                 1740             


Ala Ala  Gln Asp Lys Leu Gln  Arg Leu Gln Glu Leu  Glu Gly Thr 
    1745                 1750                 1755             


Tyr Glu  Glu Asn Glu Arg Ala  Leu Glu Ser Lys Ala  Ala Gln Leu 
    1760                 1765                 1770             


Asp Gly  Leu Glu Ala Arg Met  Arg Ser Val Leu Gln  Ala Ile Asn 
    1775                 1780                 1785             


Leu Gln  Val Gln Ile Tyr Asn  Thr Cys Gln 
    1790                 1795             


<210>  3
<211>  1609
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  4
<211>  7287
<212>  DNA
<213>  Homo sapiens

<400>  4
agcttagagt gggagggcct gggagtagaa ggtaaaaagg gagtggtgag aatgaatgtg       60

agaaggaagc caggacagcg cagtccccag tcccgaacgg ccagggagag gaggtggcct      120

agcgctggcg gggctcaccc caatccgtct gccttttgat gccgtactct gctggttgcg      180

cagccacctc gggatactgc acacggagag gagggaaaat aagcgaggca ccgccgcacc      240

acgcgggaga cctacggaga cccacagcgc ccgagccctg gaagagcact actggatgtc      300

agcggagaaa tggctttgag ctcagcctgg cgctcggttc tgcctctgtg gctcctctgg      360

agcgctgcct gctcccgcgc cgcgtccggg gacgacaacg cttttccttt tgacattgaa      420

gggagctcag cggttggcag gcaagacccg cctgagacga gcgaaccccg cgtggctctg      480

ggacgcctgc cgcctgcggc cgagaaatgc aatgctggat tctttcacac cctgtcggga      540

gaatgtgtgc cctgcgactg taatggcaat tccaacgagt gtttggacgg ctcaggatac      600

tgtgtgcact gccagcggaa cacaacagga gagcactgtg aaaagtgtct ggatggttat      660

atcggagatt ccatcagggg agcaccccaa ttctgccagc cgtgcccctg tcccctgccc      720

cacttggcca attttgcaga atcctgctat aggaaaaatg gagctgttcg gtgcatttgt      780

aacgaaaatt atgctggacc taactgtgaa agatgtgctc ccggttacta tggaaacccc      840

ttactcattg gaagcacctg taagaaatgt gactgcagtg gaaattcaga tcccaacctg      900

atctttgaag attgtgatga agtcactggc cagtgtagga attgcttacg caacaccacc      960

ggattcaagt gtgaacgttg cgctcctggc tactatgggg acgccaggat agccaagaac     1020

tgtgcagtgt gcaactgcgg gggaggccca tgtgacagtg taaccggaga atgcttggaa     1080

gaaggttttg aaccccctac aggcatggac tgcccaacca taagctgtga taagtgcgtc     1140

tgggacctga ctgatgcact gcggttagca gcgctctcca tcgaggaagg caaatccggg     1200

gtgctgagcg tatcctctgg ggccgccgct cataggcacg tgaatgaaat caacgccacc     1260

atctacctcc tcaaaacaaa attgtcagaa agagaaaacc aatacgccct aagaaagata     1320

caaatcaaca atgctgagaa cacgatgaaa agccttctgt ctgacgtaga ggaattagtt     1380

gaaaaggaaa atcaagcctc cagaaaagga caacttgttc agaaggaaag catggacacc     1440

attaaccacg caagtcagct ggtagagcaa gcccatgata tgagggataa aatccaagag     1500

atcaacaaca agatgctcta ttatggggaa gagcatgaac ttagccccaa ggaaatctct     1560

gagaagctgg tgttggccca gaagatgctt gaagagatta gaagccgtca accatttttc     1620

acccaacggg agctcgtgga tgaggaggca gatgaggctt acgaactact gagccaggct     1680

gagagctggc agcggctgca caatgagacc cgcactctgt ttcctgtcgt cctggagcag     1740

ctggatgact acaatgctaa gttgtcagat ctccaggaag cacttgacca ggcccttaac     1800

tatgtcaggg atgccgaaga catgaacagg gccacagcag ccaggcagcg ggaccatgag     1860

aaacaacagg aaagagtgag ggaacaaatg gaagtggtga acatgtctct gagcacatct     1920

gcggactctc tgacaacacc tcgtctaact ctttcagaac ttgatgatat aataaagaat     1980

gcgtcaggga tttatgcaga aatagatgga gccaaaagtg aactacaagt aaaactatct     2040

aacctaagta acctcagcca tgatttagtc caagaagcta ttgaccatgc acaggacctt     2100

caacaagaag ctaatgaatt gagcaggaag ttgcacagtt cagatatgaa cgggctggta     2160

cagaaggctt tggatgcatc aaatgtctat gaaaatattg ttaattatgt tagtgaagcc     2220

aatgaaacag cagaatttgc tttgaacacc actgaccgaa tttatgatgc ggtgagtggg     2280

attgatactc aaatcattta ccataaagat gaaagtgaga acctcctcaa tcaagccaga     2340

gaactgcaag caaaggcaga gtctagcagt gatgaagcag tggctgacac tagcaggcgt     2400

gtgggtggag ccctagcaag gaaaagtgcc cttaaaacca gactcagtga tgccgttaag     2460

caactacaag cagcagagag aggggatgcc cagcagcgcc tggggcagtc tagactgatc     2520

accgaggaag ccaacaggac gacgatggag gtgcagcagg ccactgcccc catggccaac     2580

aatctaacca actggtcaca gaatcttcaa cattttgact cttctgctta caacactgca     2640

gtgaactctg ctagggatgc agtaagaaat ctgaccgagg ttgtccctca gctcctggat     2700

cagcttcgta cggttgagca gaagcgacct gcaagcaacg tttctgccag catccagagg     2760

atccgagagc tcattgctca gaccagaagt gttgccagca agatccaagt ctccatgatg     2820

tttgatggcc agtcagctgt ggaagtgcac tcgagaacca gtatggatga cttaaaggcc     2880

ttcacgtctc tgagcctgta catgaaaccc cctgtgaagc ggccggaact gaccgagact     2940

gcagatcagt ttatcctgta cctcggaagc aaaaacgcca aaaaagagta tatgggtctt     3000

gcaatcaaaa atgataatct ggtatacgtc tataatttgg gaactaaaga tgtggagatt     3060

cccctggact ccaagcccgt cagttcctgg cctgcttact tcagcattgt caagattgaa     3120

agggtgggaa aacatggaaa ggtgttttta acagtcccga gtctaagtag cacagcagag     3180

gaaaagttca ttaaaaaggg ggaattttcg ggagatgact ctctgctgga cctggaccct     3240

gaggacacag tgttttatgt tggtggagtg ccttccaact tcaagctccc taccagctta     3300

aacctgcctg gctttgttgg ctgcctggaa ctggccactt tgaataatga tgtgatcagc     3360

ttgtacaact ttaagcacat ctataatatg gacccctcca catcagtgcc atgtgcccga     3420

gataagctgg ccttcactca gagtcgggct gccagttact tcttcgatgg ctccggttat     3480

gccgtggtga gagacatcac aaggagaggg aaatttggtc aggtgactcg ctttgacata     3540

gaagttcgaa caccagctga caacggcctt attctcctga tggtcaatgg aagtatgttt     3600

ttcagactgg aaatgcgcaa tggttaccta catgtgttct atgattttgg attcagcggt     3660

ggccctgtgc atcttgaaga tacgttaaag aaagctcaaa ttaatgatgc aaaataccat     3720

gagatctcaa tcatttacca caatgataag aaaatgatct tggtagttga cagaaggcat     3780

gtcaagagca tggataatga aaagatgaaa atacctttta cagatatata cattggagga     3840

gctcctccag aaatcttaca atccagggcc ctcagagcac accttcccct agatatcaac     3900

ttcagaggat gcatgaaggg cttccagttc caaaagaagg acttcaattt actggagcag     3960

acagaaaccc tgggagttgg ttatggatgc ccagaagact cacttatatc tcgcagagca     4020

tatttcaatg gacagagctt cattgcttca attcagaaaa tatctttctt tgatggcttt     4080

gaaggaggtt ttaatttccg aacattacaa ccaaatgggt tactattcta ttatgcttca     4140

gggtcagacg tgttctccat ctcactggat aatggtactg tcatcatgga tgtaaaggga     4200

atcaaagttc agtcagtaga taagcagtac aatgatgggc tgtcccactt cgtcattagc     4260

tctgtctcac ccacaagata tgaactgata gtagataaaa gcagagttgg gagtaagaat     4320

cctaccaaag ggaaaataga acagacacaa gcaagtgaaa agaagtttta cttcggtggc     4380

tcaccaatca gtgctcagta tgctaatttc actggctgca taagtaatgc ctactttacc     4440

agggtggata gagatgtgga ggttgaagat ttccaacggt atactgaaaa ggtccacact     4500

tctctttatg agtgtcccat tgagtcttca ccattgtttc tcctccataa aaaaggaaaa     4560

aatttatcca agcctaaagc aagtcagaat aaaaagggag ggaaaagtaa agatgcacct     4620

tcatgggatc ctgttgctct gaaactccca gagcggaata ctccaagaaa ctctcattgc     4680

cacctttcca acagccctag agcaatagag cacgcctatc aatatggagg aacagccaac     4740

agccgccaag agtttgaaca cttaaaagga gattttggtg ccaaatctca gttttccatt     4800

cgtctgagaa ctcgttcctc ccatggcatg atcttctatg tctcagatca agaagagaat     4860

gacttcatga ctctattttt ggcccatggc cgcttggttt acatgtttaa tgttggtcac     4920

aaaaaactga agattagaag ccaggagaaa tacaatgatg gcctgtggca tgatgtgata     4980

tttattcgag aaaggagcag tggccgactg gtaattgatg gtctccgagt cctagaagaa     5040

agtcttcctc ctactgaagc tacctggaaa atcaagggtc ccatttattt gggaggtgtg     5100

gctcctggaa aggctgtgaa aaatgttcag attaactcca tctacagttt tagtggctgt     5160

ctcagcaatc tccagctcaa tggggcctcc atcacctctg cttctcagac attcagtgtg     5220

accccttgct ttgaaggccc catggaaaca ggaacttact tttcaacaga aggaggatac     5280

gtggttctag atgaatcttt caatattgga ttgaagtttg aaattgcatt tgaagtccgt     5340

cccagaagca gttccggaac cctggtccac ggccacagtg tcaatgggga gtacctaaat     5400

gttcacatga aaaatggaca ggtcatagtg aaagtcaata atggcatcag agatttttcc     5460

acctcagtta cacccaagca gagtctctgt gatggcagat ggcacagaat tacagttatt     5520

agagattcta atgtggttca gttggatgtg gactctgaag tgaaccatgt ggttggaccc     5580

ctgaatccaa aaccaattga tcacagggag cctgtgtttg ttggaggtgt tccagaatct     5640

ctactgacac cacgcttggc ccccagcaaa cccttcacag gctgcatacg ccactttgtg     5700

attgatggac acccagtgag cttcagtaaa gcagccctgg tcagcggcgc cgtaagcatc     5760

aactcctgtc cagcagcctg acatgacaga gcacagctgc ccaaatacaa agttctttag     5820

agcactgaaa gaaacacaaa gccagccagg aggaacagta actcttcctt cgggtggaag     5880

ctttcatcga gttgaacagg acttaaacga atcatcaggg accggatatt tcttatttct     5940

catttggatt cttaaccttg aatccaaagt gtctgcaatg gacaacaatt gaaggagtgg     6000

caaacttact tgtattgaga gcacacgcaa ttcctactgg tgaaattact gtttctgttt     6060

ctaataaaat agaagggatt ccaaataaac acttgcacac atttttgaag tgcggctaga     6120

ttctcagatt cacctttctt ccagggaaga taactttcaa tctatataaa aatctctgtc     6180

ctaaaactac ctttctttat tttgaagaga cttactaact tacatataat ctaaattaga     6240

tgatagattt gtttttagcc cttttgtttg gtctatcagt ataagaagaa tattttaggt     6300

ttatagctga agttatcaag gtttaataaa gtaaatttct aacagaatac tagaaaaatg     6360

cagtataatt taattttttc taaataagaa acacaggaaa tcaactactt tttccccttc     6420

cttatctcct taaaagaaaa ataaaattgt acatgagagg aggcttctgt aggttattat     6480

taccattatt gtgtgttcta tgggaatcat tgaggatatc acagcaaaaa cagtaggaca     6540

aaatcataaa attcaattta agagtacaca agtcctttta ttaaaagttt gctcctagcc     6600

tgggcaacat aatgagatcc catctctgca aaaaaatttg tacatgggca tacacctgta     6660

gtcccagcta cttgggaggc tgagacggga ggatcgctta agctcaggag ttcaaggctg     6720

cagtgagcta tgactgctga ctgtacctgc actccagcct gggcaacaga gtgagatcct     6780

gtctcaaaaa caaagtgtgc tctccacata cctgcaacac aactagtctt atttctaaaa     6840

tgttataatc ttttttccaa gtagctacat taatatagtc tagaaaaaaa tggacttgaa     6900

tagctggtag aatattaaaa tatagaaatg aaataaaaga attatatcta aaaacctcaa     6960

ctcagaagac agaaaaagag aaaataggcc ctgatatcaa cagaattaac aatacataaa     7020

aggagtaact tttgagggga gaggatataa aatattttga ggaattacca aggggaataa     7080

aacaatgtta ccttgaaatg attatatata tattacatat tggtatatat gtccatacct     7140

acctatatcc cctgctaccc ttctgtctga aatatacaaa taatgataat gttgaagata     7200

tcgataaaca tagctaatgt ctgttcatag aggacttact aagtgccagc caccatgata     7260

agctaaagtt aattatttta tttgttc                                         7287


<210>  5
<211>  5817
<212>  DNA
<213>  Homo sapiens

<400>  5
gaaggcagtt tccggaggga aggggtaggg ttggggtggg ggcgctctcc gcccggtgtt       60

gcgctccttc ccagaatccg ctccggcctt tccttcctgc cgcgattccc aactttgctc      120

aaagtcgctg gactctaagc tgtcggaggg accgctggac agacctggga actgacagag      180

ggcctggagg gaaacaggcc aaagacccac aggcagagtt gacacggaac cccaaagcaa      240

ggaggagggc tcgggcccga gaccgttcac ctccccttat ccctgttccc ctcttcagga      300

tggagctgac ctcaagggaa agagggaggg gacagcctct gccctgggaa cttcgactgg      360

gcctactgct aagcgtgctg gctgccacac tggcacaggc ccctgccccg gatgtgcctg      420

gctgttccag gggaagctgc taccccgcca cgggcgacct gctggtgggc cgagctgaca      480

gactgactgc ctcatccact tgtggcctga atggccccca gccctactgc atcgtcagtc      540

acctgcagga cgaaaagaag tgcttccttt gtgactcccg gcgccccttc tctgctagag      600

acaacccaca cagccatcgc atccagaatg tagtcaccag ctttgcacca cagcggcggg      660

cagcctggtg gcagtcagag aatggtatcc ctgcggtcac catccagctg gacctggagg      720

ctgagtttca tttcacacac ctcattatga ccttcaagac atttcgccct gctgccatgc      780

tggtggaacg ctcagcagac tttggccgca cctggcatgt gtaccgatat ttctcctatg      840

actgtggggc tgacttccca ggagtcccac tagcaccccc acggcactgg gatgatgtag      900

tctgtgagtc ccgctactca gagattgagc catccactga aggcgaggtc atctatcgtg      960

tgctggaccc tgccatccct atcccagacc cctacagctc acggattcag aacctgttga     1020

agatcaccaa cctacgggtg aacctgactc gtctacacac gttgggagac aacctactcg     1080

acccacggag ggagatccga gagaagtact actatgccct ctatgagctg gttgtacgtg     1140

gcaactgctt ctgctacgga cacgcctcag agtgtgcacc cgccccaggg gcaccagccc     1200

atgctgaggg catggtgcac ggagcttgca tctgcaaaca caacacacgt ggcctcaact     1260

gcgagcagtg tcaggatttc tatcgtgacc tgccctggcg tccggctgag gacggccata     1320

gtcatgcctg taggaagtgt gagtgccatg ggcacaccca cagctgccac ttcgacatgg     1380

ccgtatacct ggcatctggc aatgtgagtg gaggtgtgtg tgatggatgt cagcataaca     1440

cagctgggcg ccactgtgag ctctgtcggc ccttcttcta ccgtgaccca accaaggacc     1500

tgcgggatcc ggctgtgtgc cgctcctgtg attgtgaccc catgggttct caagacggtg     1560

gtcgctgtga ttcccatgat gaccctgcac tgggactggt ctccggccag tgtcgctgca     1620

aagaacatgt ggtgggcact cgctgccagc aatgccgtga tggcttcttt gggctcagca     1680

tcagtgaccg tctgggctgc cggcgatgtc aatgtaatgc acggggcaca gtgcctggga     1740

gcactccttg tgaccccaac agtggatcct gttactgcaa acgtctagtg actggacgtg     1800

gatgtgaccg ctgcctgcct ggccactggg gcctgagcca cgacctgctc ggctgccgcc     1860

cctgtgactg cgacgtgggt ggtgctttgg atccccagtg tgatgagggc acaggtcaat     1920

gccactgccg ccagcacatg gttgggcgac gctgtgagca ggtgcaacct ggctacttcc     1980

ggcccttcct ggaccaccta atttgggagg ctgaggacac ccgagggcag gtgctcgatg     2040

tggtggagcg cctggtgacc cccggggaaa ctccatcctg gactggctca ggcttcgtgc     2100

ggctacagga aggtcagacc ctggagttcc tggtggcctc tgtgccgaag gctatggact     2160

atgacctgct gctgcgctta gagccccagg tccctgagca atgggcagag ttggaactga     2220

ttgtgcagcg tccagggcct gtgcctgccc acagcctgtg tgggcatttg gtgcccaagg     2280

atgatcgcat ccaagggact ctgcaaccac atgccaggta cttgatattt cctaatcctg     2340

tctgccttga gcctggtatc tcctacaagc tgcatctgaa gctggtacgg acagggggaa     2400

gtgcccagcc tgagactccc tactctggac ctggcctgct cattgactcg ctggtgctgc     2460

tgccccgtgt cctggtgcta gagatgttta gtgggggtga tgctgctgcc ctggagcgcc     2520

aggccacctt tgaacgctac caatgccatg aggagggtct ggtgcccagc aagacttctc     2580

cctctgaggc ctgcgcaccc ctcctcatca gcctgtccac cctcatctac aatggtgccc     2640

tgccatgtca gtgcaaccct caaggttcac tgagttctga gtgcaaccct catggtggtc     2700

agtgcctgtg caagcctgga gtggttgggc gccgctgtga cctctgtgcc cctggctact     2760

atggctttgg ccccacaggc tgtcaagcct gccagtgcag ccacgagggg gcactcagca     2820

gtctctgtga aaagaccagt gggcaatgtc tctgtcgaac tggtgccttt gggcttcgct     2880

gtgaccgctg ccagcgtggc cagtggggat tccctagctg ccggccatgt gtctgcaatg     2940

ggcatgcaga tgagtgcaac acccacacag gcgcttgcct gggctgccgt gatcacacag     3000

ggggtgagca ctgtgaaagg tgcattgctg gtttccacgg ggacccacgg ctgccatatg     3060

ggggccagtg ccggccctgt ccctgtcctg aaggccctgg gagccaacgg cactttgcta     3120

cttcttgcca ccaggatgaa tattcccagc agattgtgtg ccactgccgg gcaggctata     3180

cggggctgcg atgtgaagct tgtgcccctg ggcactttgg ggacccatca aggccaggtg     3240

gccggtgcca actgtgtgag tgcagtggga acattgaccc aatggatcct gatgcctgtg     3300

acccccacac ggggcaatgc ctgcgctgtt tacaccacac agagggtcca cactgtgccc     3360

actgcaagcc tggcttccat gggcaggctg cccgacagag ctgtcaccgc tgcacatgca     3420

acctgctggg cacaaatccg cagcagtgcc catctcctga ccagtgccac tgtgatccaa     3480

gcagtgggca gtgcccatgc ctccccaatg tccagggccc tagctgtgac cgctgtgccc     3540

ccaacttctg gaacctcacc agtggccatg gttgccagcc ttgtgcctgc cacccaagcc     3600

gggccagagg ccccacctgc aacgagttca cagggcagtg ccactgccgt gccggctttg     3660

gagggcggac ttgttctgag tgccaagagc tccactgggg agaccctggg ttgcagtgcc     3720

atgcctgtga ttgtgactct cgtggaatag atacacctca gtgtcaccgc ttcacaggtc     3780

actgcagctg ccgcccaggg gtgtctggtg tgcgctgtga ccagtgtgcc cgtggcttct     3840

caggaatctt tcctgcctgc catccctgcc atgcatgctt cggggattgg gaccgagtgg     3900

tgcaggactt ggcagcccgt acacagcgcc tagagcagcg ggcgcaggag ttgcaacaga     3960

cgggtgtgct gggtgccttt gagagcagct tctggcacat gcaggagaag ctgggcattg     4020

tgcagggcat cgtaggtgcc cgcaacacct cagccgcctc cactgcacag cttgtggagg     4080

ccacagagga gctgcggcgt gaaattgggg aggccactga gcacctgact cagctcgagg     4140

cagacctgac agatgtgcaa gatgagaact tcaatgccaa ccatgcacta agtggtctgg     4200

agcgagatag gcttgcactt aatctcacac tgcggcagct cgaccagcat cttgacttgc     4260

tcaaacattc aaacttcctg ggtgcctatg acagcatccg gcatgcccat agccagtctg     4320

cagaggcaga acgtcgtgcc aatacctcag ccctggcagt acctagccct gtgagcaact     4380

cggcaagtgc tcggcatcgg acagaggcac tgatggatgc tcagaaggag gacttcaaca     4440

gcaaacacat ggccaaccag cgggcacttg gcaagctctc tgcccatacc cacaccctga     4500

gcctgacaga cataaatgag ctggtgtgtg gggcaccagg ggatgcaccc tgtgctacaa     4560

gcccttgtgg gggtgccggc tgtcgagatg aggatgggca gccgcgctgt gggggcctca     4620

gctgcaatgg ggcagcggct acagcagacc tagcactggg ccgggcccgg cacacacagg     4680

cagagctgca gcgggcactg gcagaaggtg gtagcatcct cagcagagtg gctgagactc     4740

gtcggcaggc aagcgaggca cagcagcggg cccaggcagc cctggacaag gctaatgctt     4800

ccaggggaca ggtggaacag gccaaccagg aacttcaaga acttatccag agtgtgaagg     4860

acttcctcaa ccaggagggg gctgatcctg atagcattga aatggtggcc acacgggtgc     4920

tagagctctc catcccagct tcagctgagc agatccagca cctggcgggt gcgattgcag     4980

agcgagtccg gagcctggca gatgtggatg cgatcctggc acgtactgta ggagatgtgc     5040

gtcgtgccga gcagctactg caggatgcac ggcgggcaag gagctgggct gaggatgaga     5100

aacagaaggc agagacagta caggcagcac tggaggaggc ccagcgggca cagggtattg     5160

cccagggtgc catccggggg gcagtggctg acacacggga cacagagcag accctgtacc     5220

aggtacagga gaggatggca ggtgcagagc gggcactgag ctctgcaggt gaaagggctc     5280

ggcagttgga tgctctcctg gaggctctga aattgaaacg ggcaggaaat agtctggcag     5340

cctctacagc agaagaaacg gcaggcagtg cccagggtcg tgcccaggag gctgagcagc     5400

tgctacgcgg tcctctgggt gatcagtacc agacggtgaa ggccctagct gagcgcaagg     5460

cccaaggtgt gctggctgca caggcaaggg cagaacaact gcgggatgag gctcgggacc     5520

tgttgcaagc cgctcaggac aagctgcagc ggctacagga attggaaggc acctatgagg     5580

aaaatgagcg ggcactggag agtaaggcag cccagttgga cgggttggag gccaggatgc     5640

gcagcgtgct tcaagccatc aacttgcagg tgcagatcta caacacctgc cagtgacccc     5700

tgcccaaggc ctaccccagt tcctagcact gccccacatg catgtctgcc tatgcactga     5760

agagctcttg gcccggcagg gcccccaata aaccagtgtg aacccccaaa aaaaaaa        5817


<210>  6
<211>  7889
<212>  DNA
<213>  Homo sapiens

<400>  6
gtgcaggctg ctcccggggt aggtgaggga agcgcggagg cggcgcgcgg gggcagtggt       60

cggcgagcag cgcggtcctc gctaggggcg cccacccgtc agtctctccg gcgcgagccg      120

ccgccaccgc ccgcgccgga gtcaggcccc tgggccccca ggctcaagca gcgaagcggc      180

ctccggggga cgccgctagg cgagaggaac gcgccggtgc ccttgccttc gccgtgaccc      240

agcgtgcggg cggcgggatg agagggagcc atcgggccgc gccggccctg cggccccggg      300

ggcggctctg gcccgtgctg gccgtgctgg cggcggccgc cgcggcgggc tgtgcccagg      360

cagccatgga cgagtgcacg gacgagggcg ggcggccgca gcgctgcatg cccgagttcg      420

tcaacgccgc cttcaacgtg actgtggtgg ccaccaacac gtgtgggact ccgcccgagg      480

aatactgtgt gcagaccggg gtgaccgggg tcaccaagtc ctgtcacctg tgcgacgccg      540

ggcagcccca cctgcagcac ggggcagcct tcctgaccga ctacaacaac caggccgaca      600

ccacctggtg gcaaagccag accatgctgg ccggggtgca gtaccccagc tccatcaacc      660

tcacgctgca cctgggaaaa gcttttgaca tcacctatgt gcgtctcaag ttccacacca      720

gccgcccgga gagctttgcc atttacaagc gcacacggga agacgggccc tggattcctt      780

accagtacta cagtggttcc tgtgagaaca cctactccaa ggcaaaccgc ggcttcatca      840

ggacaggagg ggacgagcag caggccttgt gtactgatga attcagtgac atttctcccc      900

tcactggggg caacgtggcc ttttctaccc tggaaggaag gcccagcgcc tataactttg      960

acaatagccc tgtgctgcag gaatgggtaa ctgccactga catcagagta actcttaatc     1020

gcctgaacac ttttggagat gaagtgttta acgatcccaa agttctcaag tcctattatt     1080

atgccatctc tgattttgct gtaggtggca gatgtaaatg taatggacac gcaagcgagt     1140

gtatgaagaa cgaatttgat aagctggtgt gtaattgcaa acataacaca tatggagtag     1200

actgtgaaaa gtgtcttcct ttcttcaatg accggccgtg gaggagggca actgcggaaa     1260

gtgccagtga atgcctgccc tgtgattgca atggtcgatc ccaggaatgc tacttcgacc     1320

ctgaactcta tcgttccact ggccatgggg gccactgtac caactgccag gataacacag     1380

atggcgccca ctgtgagagg tgccgagaga acttcttccg ccttggcaac aatgaagcct     1440

gctcttcatg ccactgtagt cctgtgggct ctctaagcac acagtgtgat agttacggca     1500

gatgcagctg taagccagga gtgatggggg acaaatgtga ccgttgccag cctggattcc     1560

attctctcac tgaagcagga tgcaggccat gctcttgtga tccctctggc agcatagatg     1620

aatgtaatat tgaaacagga agatgtgttt gcaaagacaa tgtcgaaggc ttcaattgtg     1680

aaagatgcaa acctggattt tttaatctgg aatcatctaa tcctcggggt tgcacaccct     1740

gcttctgctt tgggcattct tctgtctgta caaacgctgt tggctacagt gtttattcta     1800

tctcctctac ctttcagatt gatgaggatg ggtggcgtgc ggaacagaga gatggctctg     1860

aagcatctct cgagtggtcc tctgagaggc aagatatcgc cgtgatctca gacagctact     1920

ttcctcggta cttcattgct cctgcaaagt tcttgggcaa gcaggtgttg agttatggtc     1980

agaacctctc cttctccttt cgagtggaca ggcgagatac tcgcctctct gcagaagacc     2040

ttgtgcttga gggagctggc ttaagagtat ctgtaccctt gatcgctcag ggcaattcct     2100

atccaagtga gaccactgtg aagtatgtct tcaggctcca tgaagcaaca gattaccctt     2160

ggaggcctgc tcttacccct tttgaatttc agaagctcct aaacaacttg acctctatca     2220

agatacgtgg gacatacagt gagagaagtg ctggatattt ggatgatgtc accctggcaa     2280

gtgctcgtcc tgggcctgga gtccctgcaa cttgggtgga gtcctgcacc tgtcctgtgg     2340

gatatggagg gcagttttgt gagatgtgcc tctcaggtta cagaagagaa actcctaatc     2400

ttggaccata cagtccatgt gtgctttgcg cctgcaatgg acacagcgag acctgtgatc     2460

ctgagacagg tgtttgtaac tgcagagaca atacggctgg cccgcactgt gagaagtgca     2520

gtgatgggta ctatggagat tcaactgcag gcacctcctc cgattgccaa ccctgtccgt     2580

gtcctggagg ttcaagttgt gctgttgttc ccaagacaaa ggaggtggtg tgcaccaact     2640

gtcctactgg caccactggt aagagatgtg agctctgtga tgatggctac tttggagacc     2700

ccctgggtag aaacggccct gtgagacttt gccgcctgtg ccagtgcagt gacaacatcg     2760

atcccaatgc agttggaaat tgcaatcgct tgacgggaga atgcctgaag tgcatctata     2820

acactgctgg cttctattgt gaccggtgca aagacggatt ttttggaaat cccctggctc     2880

ccaatccagc agacaaatgc aaagcctgca attgcaatct gtatgggacc atgaagcagc     2940

agagcagctg taaccccgtg acggggcagt gtgaatgttt gcctcacgtg actggccagg     3000

actgtggtgc ttgtgaccct ggattctaca atctgcagag tgggcaaggc tgtgagaggt     3060

gtgactgcca tgccttgggc tccaccaatg ggcagtgtga catccgcacc ggccagtgtg     3120

agtgccagcc cggcatcact ggtcagcact gtgagcgctg tgaggtcaac cactttgggt     3180

ttggacctga aggctgcaaa ccctgtgact gtcatcctga gggatctctt tcacttcagt     3240

gcaaagatga tggtcgctgt gaatgcagag aaggctttgt gggaaatcgc tgtgaccagt     3300

gtgaagaaaa ctatttctac aatcggtctt ggcctggctg ccaggaatgt ccagcttgtt     3360

accggctggt aaaggataag gttgctgatc atagagtgaa gctccaggaa ttagagagtc     3420

tcatagcaaa ccttggaact ggggatgaga tggtgacaga tcaagccttc gaggatagac     3480

taaaggaagc agagagggaa gttatggacc tccttcgtga ggcccaggat gtcaaagatg     3540

ttgaccagaa tttgatggat cgcctacaga gagtgaataa cactctgtcc agccaaatta     3600

gccgtttaca gaatatccgg aataccattg aagagactgg aaacttggct gaacaagcgc     3660

gtgcccatgt agagaacaca gagcggttga ttgaaatcgc atccagagaa cttgagaaag     3720

caaaagtcgc tgctgccaat gtgtcagtca ctcagccaga atctacaggg gacccaaaca     3780

acatgactct tttggcagaa gaggctcgaa agcttgctga acgtcataaa caggaagctg     3840

atgacattgt tcgagtggca aagacagcca atgatacgtc aactgaggca tacaacctgc     3900

ttctgaggac actggcagga gaaaatcaaa cagcatttga gattgaagag cttaatagga     3960

agtatgaaca agcgaagaac atctcacagg atctggaaaa acaagctgcc cgagtacatg     4020

aggaggccaa aagggccggt gacaaagctg tggagatcta tgccagcgtg gctcagctga     4080

gccctttgga ctctgagaca ctggagaatg aagcaaataa cataaagatg gaagctgaga     4140

atctggaaca actgattgac cagaaattaa aagattatga ggacctcaga gaagatatga     4200

gagggaagga acttgaagtc aagaaccttc tggagaaagg caagactgaa cagcagaccg     4260

cagaccaact cctagcccga gctgatgctg ccaaggccct cgctgaagaa gctgcaaaga     4320

agggacggga taccttacaa gaagctaatg acattctcaa caacctgaaa gattttgata     4380

ggcgtgtgaa cgataacaag acggccgcag aggaggcact aaggaagatt cctgccatca     4440

accagaccat cactgaagcc aatgaaaaga ccagagaagc ccagcaggcc ctgggcagtg     4500

ctgcggcgga tgccacagag gccaagaaca aggcccatga ggcggagagg atcgcgagcg     4560

ctgtccaaaa gaatgccacc agcaccaagg cagaagctga aagaactttt gcagaagtta     4620

cagatctgga taatgaggtg aacaatatgt tgaagcaact gcaggaagca gaaaaagagc     4680

taaagagaaa acaagatgac gctgaccagg acatgatgat ggcagggatg gcttcacagg     4740

ctgctcaaga agccgagatc aatgccagaa aagccaaaaa ctctgttact agcctcctca     4800

gcattattaa tgacctcttg gagcagctgg ggcagctgga tacagtggac ctgaataagc     4860

taaacgagat tgaaggcacc ctaaacaaag ccaaagatga aatgaaggtc agcgatcttg     4920

ataggaaagt gtctgacctg gagaatgaag ccaagaagca ggaggctgcc atcatggact     4980

ataaccgaga tatcgaggag atcatgaagg acattcgcaa tctggaggac atcaggaaga     5040

ccttaccatc tggctgcttc aacaccccgt ccattgaaaa gccctagtgt ctttagggct     5100

ggaaggcagc atccctctga caggggggca gttgtgaggc cacagagtgc cttgacacaa     5160

agattacatt tttcagaccc ccactcctct gctgctgtcc atgactgtcc ttttgaacca     5220

ggaaaagtca cagagtttaa agagaagcaa attaaacatc ctgaatcggg aacaaagggt     5280

tttatctaat aaagtgtctc ttccattcac gttgctacct tacccacact ttcccttctg     5340

atttgcgtga ggacgtggca tcctacgtta ctgtacagtg gcataagcac atcgtgtgag     5400

cccatgtatg ctggggtaga gcaagtagcc ctcccctgtc tcatcgatac cagcagaacc     5460

tcctcagtct cagtactctt gtttctatga aggaaaagtt tggctactaa cagtagcatt     5520

gtgatggcca gtatatccag tccatggata aagaaaatgc atctgcatct cctacccctc     5580

ttccttctaa gcaaaaggaa ataaacatcc tgtgccaaag gtattggtca tttagaatgt     5640

cggtagccat ccatcagtgc ttttagttat tatgagtgta ggacactgag ccatccgtgg     5700

gtcaggatgc aattatttat aaaagtctcc aggtgaacat ggctgaagat ttttctagta     5760

tattaataat tgactaggaa gatgaacttt ttttcagatc tttgggcagc tgataattta     5820

aatctggatg ggcagcttgc actcaccaat agaccaaaag acatcttttg atattcttat     5880

aaatggaact tacacagaag aaatagggat atgataacca ctaaaatttt gttttcaaaa     5940

tcaaactaat tcttacagct tttttattag ttagtcttgg aactagtgtt aagtatctgg     6000

cagagaacag ttaatcccta aggtcttgac aaaacagaag aaaaacaagc ctcctcgtcc     6060

tagtcttttc tagcaaaggg ataaaactta gatggcagct tgtactgtca gaatcccgtg     6120

tatccatttg ttcttctgtt ggagagatga gacatttgac ccttagctcc agttttcttc     6180

tgatgtttcc atcttccaga atccctcaaa aaacattgtt tgccaaatcc tggtggcaaa     6240

tacttgcact cagtatttca cacagctgcc aacgctatcg agttcctgca ctttgtgatt     6300

taaatccact ctaaaccttc cctctaagtg tagagggaag acccttacgt ggagtttcct     6360

agtgggcttc tcaacttttg atcctcagct ctgtggtttt aagaccacag tgtgacagtt     6420

ccctgccaca cacccccttc ctcctaccaa cccacctttg agattcatat atagccttta     6480

acactatgca actttgtact ttgcgtagca ggggcggggt ggggggaaag aaactattat     6540

ctgacacact ggtgctatta attatttcaa atttatattt ttgtgtgaat gttttgtgtt     6600

ttgtttatca tgattataga ataaggaatt tatgtaaata tacttagtcc tatttctaga     6660

atgacactct gttcactttg ctcaattttt cctcttcact ggcacaatgt atctgaatac     6720

ctccttccct cccttctaga attctttgga ttgtactcca aagaattgtg ccttgtgttt     6780

gcagcatctc cattctctaa aattaatata attgctttcc tccacaccca gccactgtaa     6840

agaggtaact tgggtcctct tccattgcag tcctgatgat cctaacctgc agcacggtgg     6900

ttttacaatg ttccagagca ggaacgccag gttgacaagc tatggtagga ttaggaaagt     6960

ttgctgaaga ggatctttga cgccacagtg ggactagcca ggaatgaggg agaaatgccc     7020

tttctggcaa ttgttggagc tggataggta agttttataa gggagtacat tttgactgag     7080

cacttagggc atcaggaaca gtgctactta ctgatgggta gactgggaga ggtggtgtaa     7140

cttagttctt gatgatccca cttcctgttt ccatctgctt gggatatacc agagtttacc     7200

acaagtgttt tgacgatata ctcctgagct ttcactctgc tgcttctccc aggcctcttc     7260

tactatggca ggagatgtgg cgtgctgttg caaagttttc acgtcattgt ttcctggcta     7320

gttcatttca ttaagtggct acatcctaac atatgcattt ggtcaaggtt gcagaagagg     7380

actgaagatt gactgccaag ctagtttggg tgaagttcac tccagcaagt ctcaggccac     7440

aatggggtgg tttggtttgg tttcctttta actttctttt tgttatttgc ttttctcctc     7500

cacctgtgtg gtatattttt taagcagaat tttatttttt aaaataaaag gttctttaca     7560

agatgatacc ttaattacac tcccgcaaca cagccattat tttattgtct agctccagtt     7620

atctgtattt tatgtaatgt aattgacagg atggctgctg cagaatgctg gttgacacag     7680

ggattattat actgctattt ttccctgaat ttttttcctt tgaattccaa ctgtggacct     7740

tttatatgtg ccttcacttt agctgtttgc cttaatctct acagccttgc tctccggggt     7800

ggttaataaa atgcaacact tggcattttt atgttttaag aaaaacagta ttttatttat     7860

aataaaatct gaatatttgt aacccttta                                       7889


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA primer sequence

<400>  7
gtggtaccca caggcagagt tgac                                              24


<210>  8
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA primer sequence

<400>  8
gctctagagc tcttcagtgc ataggc                                            26


