                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  ANTIBODIES TO CEA

<130>  27344

<150>  EP 11156665.9
<151>  2011-03-02

<160>  281   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Kabat

<400>  1

Glu Phe Gly Met Asn 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Kabat

<400>  2

Glu Tyr Gly Met Asn 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Kabat

<400>  3

Glu Tyr Ser Met Asn 
1               5   


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable Region


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = Ser or Gly

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = Asn or ser

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa = Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa = Thr, Ser, or Asn

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa = Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa = Val or Met

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa = Phe or Ala

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa = Val, Phe, Ser, Tyr, or Ala

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa = Asp, His, Trp, Glu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa = Val, Phe, or Leu

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa = Glu, Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa = Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa = Met or Leu

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Xaa 
            20                  25                  30          


Xaa Met Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Xaa Ile Asn Thr Lys Xaa Gly Glu Ala Xaa Tyr Xaa Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Kabat

<400>  5

Glu Phe Gly Met Ser 
1               5   


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Chothia

<400>  6

Gly Tyr Thr Phe Thr Glu Phe 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Chothia

<400>  7

Gly Tyr Thr Phe Thr Glu Tyr 
1               5           


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 AbM

<400>  8

Gly Tyr Thr Phe Thr Glu Phe Gly Met Asn 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 AbM

<400>  9

Gly Tyr Thr Phe Thr Glu Tyr Gly Met Asn 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 AbM

<400>  10

Gly Tyr Thr Phe Thr Glu Tyr Ser Met Asn 
1               5                   10  


<210>  11
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain Variable Region


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Gln, Ala, Lys, or His

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Asn, Ala, Tyr, Ile, Lys, or Thr

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa = Val, Ala, Gly, or Met

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa = Gly, Ser, Thr, or Leu

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = Thr, Asn, Pro, or Ala

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = Asn or Tyr

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa = Pro or Leu

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa = Ser, Leu, or Trp

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa = Tyr, Asn, or His

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa = Arg, Leu, Pro, or His

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa = Tyr, Ser, Gln, Lys, Phe, Pro, or Glu

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa = Ser, Gly, Ile, or Arg

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Xaa Ala Ser Xaa Xaa Xaa Xaa Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 AbM

<400>  12

Gly Tyr Thr Phe Thr Glu Phe Gly Met Ser 
1               5                   10  


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Kabat

<400>  13

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Kabat

<400>  14

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Ile Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Kabat

<400>  15

Trp Ile Asn Thr Lys Ser Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Kabat

<400>  16

Tyr Ile Asn Thr Lys Asn Gly Glu Ala Asn Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Kabat

<400>  17

Trp Ile Asn Thr Lys Asn Gly Glu Ala Thr Tyr Ile Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Chothia

<400>  18

Asn Thr Lys Thr Gly Glu Ala Thr 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Chothia

<400>  19

Asn Thr Lys Ser Gly Glu Ala Thr 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Chothia

<400>  20

Asn Thr Lys Asn Gly Glu Ala Asn 
1               5               


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 AbM

<400>  21

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 AbM

<400>  22

Trp Ile Asn Thr Lys Ser Gly Glu Ala Thr 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 AbM

<400>  23

Tyr Ile Asn Thr Lys Asn Gly Glu Ala Asn 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 AbM

<400>  24

Trp Ile Asn Thr Lys Asn Gly Glu Ala Thr 
1               5                   10  


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  25

Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  26

Trp Asp Phe Tyr His Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  27

Trp Asp Phe Val Asp Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  28

Trp Asp Phe Tyr Trp Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  29

Trp Asp Ala Phe Glu Tyr Val Lys Ala Leu Asp Tyr 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  30

Trp Asp Phe Phe Glu Tyr Phe Lys Thr Met Asp Tyr 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  31

Trp Asp Phe Phe Tyr Tyr Val Gln Thr Met Asp Tyr 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  32

Trp Asp Phe Ser Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  33

Trp Asp Phe Ala His Tyr Phe Gln Thr Met Asp Tyr 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  34

Trp Asp Phe Ala Tyr Tyr Phe Gln Thr Met Asp Tyr 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  35

Trp Asp Phe Ala Tyr Tyr Leu Glu Ala Met Asp Tyr 
1               5                   10          


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  36

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  37

Lys Ala Ser Ala Asn Val Gly Asn Asn Val Ala 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  38

Lys Ala Ser Lys Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  39

Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  40

Lys Ala Ser Gln Tyr Ala Ser Thr Asn Val Ala 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  41

Lys Ala Ser His Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  42

Lys Ala Ser Gln Ile Met Gly Pro Asn Val Ala 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  43

Lys Ala Ser Gln Ile Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  44

Lys Ala Ser Gln Lys Val Leu Thr Asn Val Ala 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  45

Lys Ala Ser Gln Thr Val Ser Ala Asn Val Ala 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  46

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  47

Tyr Leu Ala Ser Asn Leu Ser Gly 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  48

Tyr Leu Ala Ser Tyr Pro Gln Ile 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  49

Tyr Ser Ala Ser Tyr Arg Lys Arg 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  50

Tyr Trp Ala Ser Tyr Arg Tyr Ser 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  51

Tyr Ser Ala Ser His Arg Tyr Ser 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  52

Tyr Leu Ala Ser Tyr His Glu Ser 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  53

Tyr Ser Ala Ser His Arg Pro Ser 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  54

Tyr Leu Ala Ser Tyr Arg Tyr Ser 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  55

Tyr Leu Ala Ser Tyr Arg Tyr Arg 
1               5               


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3

<400>  56

His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  57
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1

<400>  57
ggatacacct tcactgagtt tggaatgaac                                        30


<210>  58
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1

<400>  58
ggatacacct tcactgagta tggtatgaac                                        30


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1

<400>  59
ggatacacct tcactgagta ttctatgaac                                        30


<210>  60

<400>  60
000

<210>  61
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1

<400>  61
ggatacacct tcactgagtt tggaatgagc                                        30


<210>  62
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2

<400>  62
tggataaaca ccaaaactgg agaggcaaca tatgttgaag agtttaaggg a                51


<210>  63
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2

<400>  63
tggataaaca ccaaaactgg agaggcaaca tatattgaag agtttaaggg a                51


<210>  64
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2

<400>  64
tggataaaca ccaaaagtgg agaggcaaca tatgttgaag agtttaaggg a                51


<210>  65
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2

<400>  65
tatataaaca ccaaaaatgg agaggcaaac tatgttgaag agtttaaggg a                51


<210>  66
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2

<400>  66
tggataaaca ccaaaaatgg agaggcaaca tatattgaag agtttaaggg a                51


<210>  67
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  67
tgggacttct atgattacgt ggaggctatg gactac                                 36


<210>  68
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  68
tgggacttct atcattacgt ggaggctatg gactac                                 36


<210>  69
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  69
tgggacttcg tggattacgt ggaggctatg gactac                                 36


<210>  70
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  70
tgggacttct attggtacgt ggaggctatg gactac                                 36


<210>  71
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  71
tgggacgcct ttgagtacgt gaaggcgctg gactac                                 36


<210>  72
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  72
tgggatttct ttgagtattt taagactatg gactac                                 36


<210>  73
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  73
tgggactttt tttattacgt gcagactatg gactac                                 36


<210>  74
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  74
tgggattttt cttattacgt tgaggcgatg gactac                                 36


<210>  75
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  75
tgggactttg ctcattactt tcagactatg gactac                                 36


<210>  76
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  76
tgggacttcg cttattactt tcagactatg gactac                                 36


<210>  77
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  77
tgggatttcg cgtattacct tgaggctatg gactac                                 36


<210>  78
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  78
aaggccagtc agaatgtggg tactaatgtt gcc                                    33


<210>  79
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  79
aaggccagtg ccaatgtggg taataatgtt gcc                                    33


<210>  80
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  80
aaggccagta agaatgtggg gactaatgtt gcg                                    33


<210>  81
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  81
aaggccagtg cggctgtggg tacgtatgtt gcg                                    33


<210>  82
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  82
aaggccagtc agatagcgag tactaatgtt gcc                                    33


<210>  83
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  83
aaggccagtc acaatgtggg taccaacgtt gcg                                    33


<210>  84
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  84
aaggccagtc agattatggg tcctaatgtt gcg                                    33


<210>  85
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  85
aaggccagtc aaattgtggg tactaatgtt gcg                                    33


<210>  86
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  86
aaggccagtc agaaggtgct tactaatgtt gcg                                    33


<210>  87
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  87
aaggccagtc agactgtgag tgctaatgtt gcg                                    33


<210>  88
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  88
tattcggcat cctaccgcta cagt                                              24


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  89
tatttggcct ccaacctctc cggt                                              24


<210>  90
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  90
tacctggcat cctaccccca gatt                                              24


<210>  91
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  91
tattcggcat cctaccgcaa aagg                                              24


<210>  92
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  92
tattgggcat cctaccgcta tagt                                              24


<210>  93
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  93
tattcggcat cccaccggta cagt                                              24


<210>  94
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  94
tatttggcat cctaccacga aagt                                              24


<210>  95
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  95
tattcggcat cccaccgtcc cagt                                              24


<210>  96
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  96
tatttggcat cctaccgcta cagt                                              24


<210>  97
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  97
tatttggcat cctaccgcta caga                                              24


<210>  98
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3

<400>  98
caccaatatt acacctatcc tctattcacg                                        30


<210>  99
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 VH

<400>  99

Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Lys Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  100
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pEM1496 huPR1A3 VH

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  101
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A

<400>  101

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  102
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV7-4-1*02

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  103
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 VL

<400>  103

Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Met Lys Arg Thr 
            100                 105                 110 


<210>  104
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pEM1495 huPR1A3 VL

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  105
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL1A

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  106
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT_hVK_1_39

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  107
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7 rF9

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Ser Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  108
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLA1 rH11

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Thr Val Ser Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr Arg Tyr Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PR1A3 VH

<400>  111
caggtgaagc tgcagcagtc aggacctgag ttgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca gaattcggaa tgaactgggt gaagcaggct      120

cctggaaagg gtttaaagtg gatgggctgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgccttc tctttggaga cctctgccac cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctaaat atttctgtgc tcgatgggat      300

ttctatgact atgttgaagc tatggactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  112
<211>  362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEM1496

<400>  112
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagttggaat gaactgggtg cgacaggccc      120

ctggacaagg gcttgagtgg atgggatgga taaacaccaa aactggagag gcaacatatg      180

ttgaagagtt taagggacgg tttgtcttct ccttggacac ctctgtcagc acggcatatc      240

tgcagatcag cagcctaaag gctgacgaca ctgccgtgta ttactgtgcg agatgggact      300

tctatgatta cgtggaggct atggactact ggggccaagg gaccacggtc accgtctcct      360

ca                                                                     362


<210>  113
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A

<400>  113
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  114
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV7-4-1*02

<400>  114
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacacca acactgggaa cccaacgtat      180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaggac actgccgtgt attactgtgc gaga            294


<210>  115
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PR1A3 VL

<400>  115
gatatcgtga tgacccagtc tcaaagattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgttg cctggtatca acagaaacca      120

ggacaatccc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtacagtct      240

gaagacttgg cggagtattt ctgtcaccaa tattacacct atcctctatt cacgttcggc      300

tcggggacaa agttggaaat gaaacgtacg                                       330


<210>  116
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEM1495

<400>  116
gacatccaga tgactcagag cccaagcagc ctgagcgcca gcgtgggtga cagagtgacc       60

atcacctgta aggccagtca gaatgtgggt actaatgttg cctggtacca gcagaagcca      120

ggtaaggctc caaagctgct gatctactcg gcatcctacc ggtacagtgg tgtgccaagc      180

agattcagcg gtagcggtag cggtaccgac ttcaccttca ccatcagcag cctccagcca      240

gaggacatcg ccacctacta ctgccaccaa tattacacct atcctctatt cagcttcggc      300

caagggacca aggtggaaat caaacgt                                          327


<210>  117
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CL1A

<400>  117
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca gaatgtgggt actaatgttg cctggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gctacagtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caag                                             324


<210>  118
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IMGT_hVK_1_39

<400>  118
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccct                      285


<210>  119
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7 rF9

<400>  119
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtatggta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacga aatctggaga ggcaacctat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tcagctagc                                                              369


<210>  120
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLA1 rH11

<400>  120
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca gactgtgagt gctaatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctacttg gcatcctacc gctacagagg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  121
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1

<400>  121
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca       60

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagcaga gcccaaatct      300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      840

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      960

agcctctccc tgtctccggg taaatga                                          987


<210>  122
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1

<400>  122

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
1               5                   10                  15      


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            20                  25                  30          


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        35                  40                  45              


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
65                  70                  75                  80  


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala 
                85                  90                  95      


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            100                 105                 110         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
145                 150                 155                 160 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                165                 170                 175     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            180                 185                 190         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        195                 200                 205             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    210                 215                 220                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
225                 230                 235                 240 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                245                 250                 255     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            260                 265                 270         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        275                 280                 285             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    290                 295                 300                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
305                 310                 315                 320 


Ser Leu Ser Leu Ser Pro Gly Lys 
                325             


<210>  123
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer MS-43

<400>  123
ccagccggcc atggccgata tccagatgac ccagtctcca tc                          42


<210>  124
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer MS-52

<400>  124
gaagaccgat gggcctttgg tgctag                                            26


<210>  125
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer MS-55

<400>  125
gcaacatatg ttgaagagtt taagggacgg                                        30


<210>  126
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS-56

<400>  126
atgaactggg tgcgacaggc ccctg                                             25


<210>  127
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-679


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  w is a or t

<400>  127
caggggcctg tcgcacccag ttcatmnnaw actcagtgaa ggtgtatcca gaagcc           56


<210>  128
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-680

<400>  128
ccgtccctta aactcttcaa cataggttgc ctctccagtt ttggtgttta tccatcccat       60

ccactcaagc ccttgtccag g                                                 81


<210>  129
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-685

<400>  129
cagctatgac catgattacg ccaagcttgc atgcaaattc tatttcaagg                  50


<210>  130
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-686

<400>  130
gttgcgtggt atcagcagaa accaggg                                           27


<210>  131
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-687

<400>  131
gctctttgtg acgggcgagc tcaggccctg atgg                                   34


<210>  132
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer EAB-688

<400>  132
ggagtcccat caaggttcag tggcagtgga tctgg                                  35


<210>  133
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-681

<400>  133
cctggtttct gctgatacca cgcaacatta gtacccacat tctgactggc cttgcaagtg       60

atggtgactc                                                              70


<210>  134
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-682

<400>  134
ctgccactga accttgatgg gactccactg tagcggtagg atgccgaata gatcaggagc       60

ttaggtgctt tccctgg                                                      77


<210>  135
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC7


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<400>  135
ccagtagtcc atagcctcca cgtaatcata gaagtcmnnt ctcgcacagt aatacacggc       60

agtg                                                                    64


<210>  136
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC8


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<400>  136
ccagtagtcc atagcctcca cgtaatcata gaamnnccat ctcgcacagt aatacacggc       60

agtg                                                                    64


<210>  137
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC9


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<400>  137
ccagtagtcc atagcctcca cgtaatcata mnngtcccat ctcgcacagt aatacacggc       60

agtg                                                                    64


<210>  138
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC10


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  138
ccagtagtcc atagcctcca cgtaatcmnn gaagtcccat ctcgcacagt aatacacggc       60

agtg                                                                    64


<210>  139
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC11


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  139
ccagtagtcc atagcctcca cgtamnnata gaagtcccat ctcgcacagt aatacacggc       60

agtg                                                                    64


<210>  140
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC12


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<400>  140
cgtggtccct tggccccagt agtccatagc ctccacmnna tcatagaagt cccatctcgc       60

acag                                                                    64


<210>  141
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC13


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<400>  141
cgtggtccct tggccccagt agtccatagc ctcmnngtaa tcatagaagt cccatctcgc       60

acag                                                                    64


<210>  142
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC14


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<400>  142
cgtggtccct tggccccagt agtccatagc mnncacgtaa tcatagaagt cccatctcgc       60

acag                                                                    64


<210>  143
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC15


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  143
cgtggtccct tggccccagt agtccatmnn ctccacgtaa tcatagaagt cccatctcgc       60

acag                                                                    64


<210>  144
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC16


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  144
cgtggtccct tggccccagt agtcmnnagc ctccacgtaa tcatagaagt cccatctcgc       60

acag                                                                    64


<210>  145
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC17

<400>  145
cgtggtccct tggccccagt agtccatagc ctccacgtaa tcatagaagt cccatctcgc       60

acagtaatac acggcag                                                      77


<210>  146
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-749

<400>  146
ccatcagggc ctgagctcgc ccgtc                                             25


<210>  147
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-750

<400>  147
cgtggaggct atggactact ggggccaagg                                        30


<210>  148
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-751

<400>  148
gactactggg gccaagggac cacggtcac                                         29


<210>  149
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-752

<400>  149
ggtcagggcg cctgagttcc acg                                               23


<210>  150
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC1


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<400>  150
ggtgccctgg ccaaacgtga atagaggata ggtgtamnnt tggtgacagt agtaagttgc       60


<210>  151
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC2


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<400>  151
ggtgccctgg ccaaacgtga atagaggata ggtmnnatat tggtgacagt agtaagttgc       60


<210>  152
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC3


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<400>  152
ggtgccctgg ccaaacgtga atagaggata mnngtaatat tggtgacagt agtaagttgc       60


<210>  153
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC4


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  153
ggtgccctgg ccaaacgtga atagaggmnn ggtgtaatat tggtgacagt agtaagttgc       60


<210>  154
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer AC5


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  154
ggtgccctgg ccaaacgtga amnnaggata ggtgtaatat tggtgacagt agtaagttgc       60


<210>  155
<211>  60
<212>  DNA
<213>  Artificial Sequences

<220>
<223>  Primer AC6

<400>  155
ggtgccctgg ccaaacgtga atagaggata ggtgtaatat tggtgacagt agtaagttgc       60


<210>  156
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer EAB-746

<400>  156
cgcttgatct cgagcttggt gccctggcca aacgtg                                 36


<210>  157

<400>  157
000

<210>  158
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pETR6592

<400>  158

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Met Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile Asn 
225                 230                 235                 240 


Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys Ile Thr 
                245                 250                 255     


Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr 
            260                 265                 270         


Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Ile Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Leu Ile Asn Val Asp Leu Glu Val Leu Phe Gln 
385                 390                 395                 400 


Gly Pro Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
                405                 410                 415     


Trp His Glu Ala Arg Ala His His His His His His 
            420                 425             


<210>  159
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PMS22

<400>  159
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  160
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1C8

<400>  160
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatcatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  161
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3E1

<400>  161
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttcgtggatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  162
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D7

<400>  162
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctattggt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  163
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affinity Matured Heavy Chain

<400>  163
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

tttgctcatt actttcagac tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  164
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affinity Matured Heavy Chain

<400>  164
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttcgcttatt actttcagac tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  165
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affinity Matured Heavy Chain

<400>  165
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggat      300

ttcgcgtatt accttgaggc tatggactac tggggccaag ggaccacgat caccgtctcc      360

tca                                                                    363


<210>  166
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 19

<400>  166
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgctgtgt attactgtgc gagatgggac      300

gcctttgagt acgtgaaggc gctggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  167
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 8

<400>  167
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggat      300

ttctttgagt attttaagac tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  168
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 28

<400>  168
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

tttttttatt acgtgcagac tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  169
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 27

<400>  169
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggat      300

ttttcttatt acgttgaggc gatggactac tggggccaag ggaccacagt caccgtctcc      360

tca                                                                    363


<210>  170
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H4E9 Heavy Chain

<400>  170
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaatacca aaactggaga ggcaacttat      180

attgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  171
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC14 (B9)

<400>  171
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaagtggaga ggcaacctat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  172
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC15 (F9)

<400>  172
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtatggta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacga aatctggaga ggcaacctat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  173
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 2

<400>  173
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtattcta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatac ataaacacca aaaatggaga ggcaaactat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  174
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 11

<400>  174
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtatggta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaaatggaga ggcaacctat      180

attgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  175
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 13

<400>  175
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ataaacacca aaaatggaga ggcaaactat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggacg cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  176
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 14

<400>  176
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtatggta tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ataaacacca aaaatggaga ggcaaactat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  177
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 19

<400>  177
caggtgcaat tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgctgtgt attactgtgc gagatgggac      300

gcctttgagt acgtgaaggc gctggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  178
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC21 (3A1)

<400>  178
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc caatgtgggt aataatgttg cctggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctatttg gcctccaacc gctccggtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  179
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC19 (2C6)

<400>  179
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtaa gaatgtgggg actaatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagcccct gatctacctg gcatcctacc cccagattgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcccctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  180
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC18 (2F1)

<400>  180
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  181
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC23 (2F11)

<400>  181
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca gatagcgagt actaatgttg cctggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattgg gcatcctacc gctatagtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  182
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H4E9 light chain

<400>  182
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca gaatgtgggt actaatgttg cctggtatca gcagaaacca      120

gggaaagcac ctaagcccct gatctattcg gcatcctacc gctacagtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  183
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L2D2

<400>  183
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca caatgtgggt accaacgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcccacc ggtacagtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  184
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC6 (C1)

<400>  184
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca gattatgggt cctaatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctatttg gcatcctacc acgaaagtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  185
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC7 (E10)

<400>  185
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca aattgtgggt actaatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcccacc gtcccagtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  186
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC12 (H7)

<400>  186
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca gaaggtgctt actaatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctatttg gcatcctacc gctacagtgg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  187
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAC13 (H11)

<400>  187
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtca gactgtgagt gctaatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctacttg gcatcctacc gctacagagg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg                                       330


<210>  188
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PMS22

<400>  188

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  189
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C8

<400>  189

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr His Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  190
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E1

<400>  190

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Val Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  191
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D7

<400>  191

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Trp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  192
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured Heavy Chain

<400>  192

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala His Tyr Phe Gln Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  193
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured Heavy Chain

<400>  193

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Phe Gln Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  194
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured Heavy Chain

<400>  194

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Leu Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Ile Thr Val Ser Ser 
        115                 120     


<210>  195
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 19

<400>  195

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Ala Phe Glu Tyr Val Lys Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  196
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 8

<400>  196

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Phe Glu Tyr Phe Lys Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  197
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 28

<400>  197

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Phe Tyr Tyr Val Gln Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  198
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 27

<400>  198

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ser Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  199
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4E9 Heavy Chain

<400>  199

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Ile Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  200
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC14 (B9)

<400>  200

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Ser Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  201
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC15 (F9)

<400>  201

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Ser Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  202
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 2

<400>  202

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Lys Asn Gly Glu Ala Asn Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  203
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 11

<400>  203

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Asn Gly Glu Ala Thr Tyr Ile Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  204
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 13

<400>  204

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Lys Asn Gly Glu Ala Asn Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Ala Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  205
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1/H2 (5) 14

<400>  205

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Lys Asn Gly Glu Ala Asn Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  206
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 Full (5) 19

<400>  206

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Ala Phe Glu Tyr Val Lys Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  207
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC21 (3A1)

<400>  207

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg Ser Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  208
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC19 (2C6)

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Lys Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr Pro Gln Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  209
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC18 (2F1)

<400>  209

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  210
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC23 (2F11)

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ile Ala Ser Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  211
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4E9 light chain

<400>  211

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  212
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2D2

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser His Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser His Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  213
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC6 (C1)

<400>  213

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ile Met Gly Pro Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr His Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  214
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC7 (E10)

<400>  214

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ile Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser His Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  215
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC12 (H7)

<400>  215

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Lys Val Leu Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  216
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAC13 (H11)

<400>  216

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Thr Val Ser Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr Arg Tyr Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  217
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (Y98A) Heavy Chain CDR3

<400>  217

Trp Asp Phe Ala Asp Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  218
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (D99Y) Heavy Chain CDR3

<400>  218

Trp Asp Phe Tyr Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  219
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (D99H) Heavy Chain CDR3

<400>  219

Trp Asp Phe Tyr His Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  220
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (V101F) Heavy Chain CDR3

<400>  220

Trp Asp Phe Tyr Asp Tyr Phe Glu Ala Met Asp Tyr 
1               5                   10          


<210>  221
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (E101aQ) Heavy Chain CDR3

<400>  221

Trp Asp Phe Tyr Asp Tyr Val Gln Ala Met Asp Tyr 
1               5                   10          


<210>  222
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (A103T) Heavy Chain CDR3

<400>  222

Trp Asp Phe Tyr Asp Tyr Val Glu Thr Met Asp Tyr 
1               5                   10          


<210>  223
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (Y98A / D99Y) Heavy Chain CDR3

<400>  223

Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  224
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3 (W95Y) Heavy Chain CDR3

<400>  224

Tyr Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  225
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (Y98A) Heavy Chain Construct

<400>  225

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  226
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (D99Y) Heavy Chain Construct

<400>  226

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  227
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (D99H) Heavy Chain Construct

<400>  227

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr His Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  228
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (V101F) Heavy Chain Construct

<400>  228

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Phe Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  229
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (E102Q) Heavy Chain Construct

<400>  229

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Gln Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  230
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (A103T) Heavy Chain Construct

<400>  230

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  231
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (Y98A / D99Y) Heavy Chain Construct

<400>  231

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  232
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH7A (W95Y) Heavy Chain Construct

<400>  232

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  233
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CH1A1A  (Y98A)

<400>  233

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  234
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A  (D99Y)

<400>  234

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  235
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CH1A1A (D99H)

<400>  235

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr His Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  236
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CH1A1A  (V101F)

<400>  236

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Phe Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  237
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CH1A1A  (E102Q)

<400>  237

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Gln Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  238
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CH1A1A  (A103T)

<400>  238

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  239
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CH1A1A  (Y98A / D99Y)

<400>  239

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  240
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CH1A1A  (W95Y)

<400>  240

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  241
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (Y98A)

<400>  241

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  242
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (D99Y)

<400>  242

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  243
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (D99H)

<400>  243

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr His Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  244
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (V101F)

<400>  244

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Phe Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  245
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (E102Q)

<400>  245

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Gln Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  246
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (A103T)

<400>  246

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  247
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (Y98A / D99Y)

<400>  247

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  248
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B (W95Y)

<400>  248

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  249
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (Y98A) Heavy Chain Construct

<400>  249
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttcgctgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  250
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (D99Y) Heavy Chain Construct

<400>  250
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctattatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  251
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (D99H) Heavy Chain Construct

<400>  251
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatcatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  252
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (V101F) Heavy Chain Construct

<400>  252
ccaggtgcag ctggtgcaat ctgggtctga gttgaagaag cctggggcct cagtgaaggt       60

ttcctgcaag gcttctggat acaccttcac tgagtttgga atgaactggg tgcgacaggc      120

ccctggacaa gggcttgagt ggatgggatg gataaacacc aaaactggag aggcaacata      180

tgttgaagag tttaagggac ggtttgtctt ctccttggac acctctgtca gcacggcata      240

tctgcagatc agcagcctaa aggctgaaga cactgccgtg tattactgtg cgagatggga      300

cttctatgat tacttcgagg ctatggacta ctggggccaa gggaccacgg tcaccgtctc      360

ctca                                                                   364


<210>  253
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (E102Q) Heavy Chain Construct

<400>  253
ccaggtgcag ctggtgcaat ctgggtctga gttgaagaag cctggggcct cagtgaaggt       60

ttcctgcaag gcttctggat acaccttcac tgagtttgga atgaactggg tgcgacaggc      120

ccctggacaa gggcttgagt ggatgggatg gataaacacc aaaactggag aggcaacata      180

tgttgaagag tttaagggac ggtttgtctt ctccttggac acctctgtca gcacggcata      240

tctgcagatc agcagcctaa aggctgaaga cactgccgtg tattactgtg cgagatggga      300

cttctatgat tacgtgcagg ctatggacta ctggggccaa gggaccacgg tcaccgtctc      360

ctca                                                                   364


<210>  254
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (A103T) Heavy Chain Construct

<400>  254
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttctatgatt acgtggagac tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  255
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (Y98A / D99Y) Heavy Chain Construct

<400>  255
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttcgcttatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  256
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH7A (W95Y) Heavy Chain Construct

<400>  256
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatacgac      300

ttctatgatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  257
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1

<400>  257

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  258
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A2

<400>  258

Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  259
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A3

<400>  259

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  260
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A4

<400>  260

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Lys Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  261
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A

<400>  261

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  262
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1B

<400>  262

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  263
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1C

<400>  263

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  264
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1D

<400>  264

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  265
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1E

<400>  265

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  266
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1F

<400>  266

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  267
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1G

<400>  267

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  268
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1

<400>  268
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accctggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  269
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A2

<400>  269
caggtcaaac tgcagcagag cggccctgag ctgaagaaac ccggcgagac agtgaagatc       60

agctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggca      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccatg accaccgaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  270
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A3

<400>  270
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt caagcaggcc      120

cctggcaagg gcctgaagtg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccatg accaccgaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  271
<211>  362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A4

<400>  271
aggtgcagct ggtgcagtct ggcgccgaag tgaagaaacc tggcgccagc gtgaaggtgt       60

cctgcaaggc cagcggctac accttcaccg agttcggcat gaactgggtc cgacaggcac      120

caggccaggg cctcgaatgg atgggctgga tcaacaccaa gaccggcgag gccacctacg      180

tggaagagtt caagggcaga ttcgccttca gcctggaaac cagcgccacc accgcctacc      240

tgcagatcaa caacctgaag aacgaggata ccgccaagta cttctgcgcc agatgggact      300

tctacgatta cgtggaagcc atggactact ggggccaggg caccaccgtg accgtgtcta      360

gc                                                                     362


<210>  272
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A

<400>  272
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  273
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1B

<400>  273
caggtgaagc tgcagcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccatg accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  274
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1C

<400>  274
caggtgcagc tggtgcagtc tggccccgaa ctgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccatg accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  275
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1D

<400>  275
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagagac tgtgaagatc       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccatg accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  276
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1E

<400>  276
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag attcaccatg accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  277
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1F

<400>  277
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccatg accacggaca ccagcaccag caccgcctac      240

ctggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  278
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1G

<400>  278
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccatg accacggaca ccagcaccag caccgcctac      240

atggaaatcc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttctacgatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  279
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A

<400>  279

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  280
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A

<400>  280
caggtgcagc tggtgcagtc tggcgctgag gtgaagaagc ctggcgcctc ggtgaaggtc       60

tcctgcaagg cctctggtta cacatttacg gaattcggga tgaattgggt cagacaagca      120

cctgggcaag ggctcgagtg gatgggatgg ataaacacga agacaggcga ggccacctac      180

gtagaagagt tcaaaggaag ggtcacgatg accacagata cttctacctc tactgcgtat      240

atggaactac ggagcttgcg tagcgatgac acagcggtgt actattgtgc tcgatgggat      300

ttctatgact atgttgaagc tatggactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  281
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR1A3

<400>  281

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Tyr Asp Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


