                         SEQUENCE LISTING

<110>  The Governing Council of the University of Toronto
 
<120>  Gluco-Oligosaccharide Oxidases from Acremonium Strictum and Uses 
       Thereof

<130>  31100037

<140>  PCT/CA2012.999171
<141>  2012-02-28

<150>  US 61/447,550
<151>  2011-02-28

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1425
<212>  DNA
<213>  Acremonium strictum

<400>  1
aactcaatca acgcctgtct cgccgccgcc gacgtcgagt tccacgagga agactccgag       60

ggctgggaga tggacggcac agccttcaac ctccgcgtcg actacgaccc ggtcgccatt      120

gccatccctc gctccaccga ggacatcgct gccgctgttc agtgcggtct tgatgctggt      180

gtgcagatct cggcaaaggg tggtggtcac agttatggtt cttatgggtt tggtggtgag      240

gatggtcatt tgatgttgga gttggatcgt atgtaccgtg tgtcggttga tgatgataat      300

gtcgcgacta ttcagggtgg tgctcgtctt ggatacactg ctcttgagct tcttgaccag      360

ggtaaccgtg ccctgactca cggtacctgc cctgctgtcg gtatcggtgg ccacgttctc      420

ggtggcggct acgggtttgc tacccacacc cacggtctga ctctcgactg gctcgtcggt      480

gccaccgtcg tcctggccga tgcctccatc gtgcacgtct ccaagaccga gaacgcagat      540

ctcttctggg ccctccgcgg tggcggcggt ggtttcgcca tcgtctccga gttcgagttc      600

aacaccttcg aggctccgga gatcatcacc acctaccagg tcaccaccac ctggaaccgg      660

aaacagcacg ttgccggtct caaggctctc caggactggg ctgagaacac catgcccagg      720

gagctcagca tgcgtcttga gatcaacgcc aatgccctca attgggaggg taactacttc      780

ggtaacgcca aggatttgaa gaaggttctt cagcctatca tgaagaaggc tggtggcaag      840

tctaccatct ctaagcttgt tgagaccgat tggtatggcc agatcaacac ctacttgtac      900

ggtgctgacc tcaacattac ctacaactac gacgtccacg agtacttcta cgccaacagc      960

ttgaccgccc cccgcctctc cgatgaagcc atctccgcct tcgtcgacta caaattcgac     1020

aactcctccg tccgccccgg ccgcggctgg tggatccaat gggacttcca cggcggcaag     1080

aactccgccc tcgcctccca ctccaacgac gagaccgcct acgcccaccg cgaccagctc     1140

tggctctggc agttctacga caacatctac gactacgaga acaacacctc tccctaccct     1200

gagagcgggt tcgagttcat gcagggtttt gtcgccacta ttgaagacac gcttcctgag     1260

gacaggaagg gcaagtactt caactatgct gatactacgc ttgataagga ggaggcgcag     1320

aagttgtact ggaggggtaa ccttgagaag ctgcaggcta tcaaggccaa gtatgaccct     1380

gaggatgtgt ttggtaatgt tgtctctgtt gagcccattg cctag                     1425


<210>  2
<211>  474
<212>  PRT
<213>  Acremonium strictum

<400>  2

Asn Ser Ile Asn Ala Cys Leu Ala Ala Ala Asp Val Glu Phe His Glu 
1               5                   10                  15      


Glu Asp Ser Glu Gly Trp Glu Met Asp Gly Thr Ala Phe Asn Leu Arg 
            20                  25                  30          


Val Asp Tyr Asp Pro Val Ala Ile Ala Ile Pro Arg Ser Thr Glu Asp 
        35                  40                  45              


Ile Ala Ala Ala Val Gln Cys Gly Leu Asp Ala Gly Val Gln Ile Ser 
    50                  55                  60                  


Ala Lys Gly Gly Gly His Ser Tyr Gly Ser Tyr Gly Phe Gly Gly Glu 
65                  70                  75                  80  


Asp Gly His Leu Met Leu Glu Leu Asp Arg Met Tyr Arg Val Ser Val 
                85                  90                  95      


Asp Asp Asp Asn Val Ala Thr Ile Gln Gly Gly Ala Arg Leu Gly Tyr 
            100                 105                 110         


Thr Ala Leu Glu Leu Leu Asp Gln Gly Asn Arg Ala Leu Thr His Gly 
        115                 120                 125             


Thr Cys Pro Ala Val Gly Ile Gly Gly His Val Leu Gly Gly Gly Tyr 
    130                 135                 140                 


Gly Phe Ala Thr His Thr His Gly Leu Thr Leu Asp Trp Leu Val Gly 
145                 150                 155                 160 


Ala Thr Val Val Leu Ala Asp Ala Ser Ile Val His Val Ser Lys Thr 
                165                 170                 175     


Glu Asn Ala Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Gly Gly Phe 
            180                 185                 190         


Ala Ile Val Ser Glu Phe Glu Phe Asn Thr Phe Glu Ala Pro Glu Ile 
        195                 200                 205             


Ile Thr Thr Tyr Gln Val Thr Thr Thr Trp Asn Arg Lys Gln His Val 
    210                 215                 220                 


Ala Gly Leu Lys Ala Leu Gln Asp Trp Ala Glu Asn Thr Met Pro Arg 
225                 230                 235                 240 


Glu Leu Ser Met Arg Leu Glu Ile Asn Ala Asn Ala Leu Asn Trp Glu 
                245                 250                 255     


Gly Asn Tyr Phe Gly Asn Ala Lys Asp Leu Lys Lys Val Leu Gln Pro 
            260                 265                 270         


Ile Met Lys Lys Ala Gly Gly Lys Ser Thr Ile Ser Lys Leu Val Glu 
        275                 280                 285             


Thr Asp Trp Tyr Gly Gln Ile Asn Thr Tyr Leu Tyr Gly Ala Asp Leu 
    290                 295                 300                 


Asn Ile Thr Tyr Asn Tyr Asp Val His Glu Tyr Phe Tyr Ala Asn Ser 
305                 310                 315                 320 


Leu Thr Ala Pro Arg Leu Ser Asp Glu Ala Ile Ser Ala Phe Val Asp 
                325                 330                 335     


Tyr Lys Phe Asp Asn Ser Ser Val Arg Pro Gly Arg Gly Trp Trp Ile 
            340                 345                 350         


Gln Trp Asp Phe His Gly Gly Lys Asn Ser Ala Leu Ala Ser His Ser 
        355                 360                 365             


Asn Asp Glu Thr Ala Tyr Ala His Arg Asp Gln Leu Trp Leu Trp Gln 
    370                 375                 380                 


Phe Tyr Asp Asn Ile Tyr Asp Tyr Glu Asn Asn Thr Ser Pro Tyr Pro 
385                 390                 395                 400 


Glu Ser Gly Phe Glu Phe Met Gln Gly Phe Val Ala Thr Ile Glu Asp 
                405                 410                 415     


Thr Leu Pro Glu Asp Arg Lys Gly Lys Tyr Phe Asn Tyr Ala Asp Thr 
            420                 425                 430         


Thr Leu Asp Lys Glu Glu Ala Gln Lys Leu Tyr Trp Arg Gly Asn Leu 
        435                 440                 445             


Glu Lys Leu Gln Ala Ile Lys Ala Lys Tyr Asp Pro Glu Asp Val Phe 
    450                 455                 460                 


Gly Asn Val Val Ser Val Glu Pro Ile Ala 
465                 470                 


<210>  3
<211>  1425
<212>  DNA
<213>  Acremonium strictum

<400>  3
aactcaatca acgcctgtct cgccgccgcc gacgtcgagt tccacgagga agactccgag       60

ggctgggaga tggacggcac agccttcaac ctccgcgtcg actacgaccc ggtcgccatt      120

gccatccctc gctccaccga ggacatcgct gccgctgttc agtgcggtct tgatgctggt      180

gtgcagatct cggcaaaggg tggtggtcac agttatggtt cttatgggtt tggtggtgag      240

gatggtcatt tgatgttgga gttggatcgt atgtaccgtg tgtcggttga tgatgataat      300

gtcgcgacta ttcagggtgg tgctcgtctt ggatacactg ctcttgagct tcttgaccag      360

ggtaaccgtg ccctgactca cggtacctgc cctgctgtcg gtatcggtgg ccacgttctc      420

ggtggcggct acgggtttgc tacccacacc cacggtctga ctctcgactg gctcgtcggt      480

gccaccgtcg tcctggccga tgcctccatc gtgcacgtct ccaagaccga gaacgcagat      540

ctcttctggg ccctccgcgg tggcggcggt ggtttcgcca tcgtctccga gttcgagttc      600

aacaccttcg aggctccgga gatcatcacc acctaccagg tcaccaccac ctggaaccgg      660

aaacagcacg ttgccggtct caaggctctc caggactggg ctgagaacac catgcccagg      720

gagctcagca tgcgtcttga gatcaacgcc aatgccctca attgggaggg taactacttc      780

ggtaacgcca aggatttgaa gaaggttctt cagcctatca tgaagaaggc tggtggcaag      840

tctaccatct ctaagcttgt tgagaccgat tggtatggcc agatcaacac ctacttggcc      900

ggtgctgacc tcaacattac ctacaactac gacgtccacg agtacttcta cgccaacagc      960

ttgaccgccc cccgcctctc cgatgaagcc atctccgcct tcgtcgacta caaattcgac     1020

aactcctccg tccgccccgg ccgcggctgg tggatccaat gggacttcca cggcggcaag     1080

aactccgccc tcgcctccca ctccaacgac gagaccgcct acgcccaccg cgaccagctc     1140

tggctctggc agttctacga caacatctac gactacgaga acaacacctc tccctaccct     1200

gagagcgggt tcgagttcat gcagggtttt gtcgccacta ttgaagacac gcttcctgag     1260

gacaggaagg gcaagtactt caactatgct gatactacgc ttgataagga ggaggcgcag     1320

aagttgtact ggaggggtaa ccttgagaag ctgcaggcta tcaaggccaa gtatgaccct     1380

gaggatgtgt ttggtaatgt tgtctctgtt gagcccattg cctag                     1425


<210>  4
<211>  1425
<212>  DNA
<213>  Acremonium strictum

<400>  4
aactcaatca acgcctgtct cgccgccgcc gacgtcgagt tccacgagga agactccgag       60

ggctgggaga tggacggcac agccttcaac ctccgcgtcg actacgaccc ggtcgccatt      120

gccatccctc gctccaccga ggacatcgct gccgctgttc agtgcggtct tgatgctggt      180

gtgcagatct cggcaaaggg tggtggtcac agttatggtt cttatgggtt tggtggtgag      240

gatggtcatt tgatgttgga gttggatcgt atgtaccgtg tgtcggttga tgatgataat      300

gtcgcgacta ttcagggtgg tgctcgtctt ggatacactg ctcttgagct tcttgaccag      360

ggtaaccgtg ccctgactca cggtacctgc cctgctgtcg gtatcggtgg ccacgttctc      420

ggtggcggct acgggtttgc tacccacacc cacggtctga ctctcgactg gctcgtcggt      480

gccaccgtcg tcctggccga tgcctccatc gtgcacgtct ccaagaccga gaacgcagat      540

ctcttctggg ccctccgcgg tggcggcggt ggtttcgcca tcgtctccga gttcgagttc      600

aacaccttcg aggctccgga gatcatcacc acctaccagg tcaccaccac ctggaaccgg      660

aaacagcacg ttgccggtct caaggctctc caggactggg ctgagaacac catgcccagg      720

gagctcagca tgcgtcttga gatcaacgcc aatgccctca attgggaggg taactacttc      780

ggtaacgcca aggatttgaa gaaggttctt cagcctatca tgaagaaggc tggtggcaag      840

tctaccatct ctaagcttgt tgagaccgat tggtatggcc agatcaacac ctacttgaac      900

ggtgctgacc tcaacattac ctacaactac gacgtccacg agtacttcta cgccaacagc      960

ttgaccgccc cccgcctctc cgatgaagcc atctccgcct tcgtcgacta caaattcgac     1020

aactcctccg tccgccccgg ccgcggctgg tggatccaat gggacttcca cggcggcaag     1080

aactccgccc tcgcctccca ctccaacgac gagaccgcct acgcccaccg cgaccagctc     1140

tggctctggc agttctacga caacatctac gactacgaga acaacacctc tccctaccct     1200

gagagcgggt tcgagttcat gcagggtttt gtcgccacta ttgaagacac gcttcctgag     1260

gacaggaagg gcaagtactt caactatgct gatactacgc ttgataagga ggaggcgcag     1320

aagttgtact ggaggggtaa ccttgagaag ctgcaggcta tcaaggccaa gtatgaccct     1380

gaggatgtgt ttggtaatgt tgtctctgtt gagcccattg cctag                     1425


<210>  5
<211>  1425
<212>  DNA
<213>  Acremonium strictum

<400>  5
aactcaatca acgcctgtct cgccgccgcc gacgtcgagt tccacgagga agactccgag       60

ggctgggaga tggacggcac agccttcaac ctccgcgtcg actacgaccc ggtcgccatt      120

gccatccctc gctccaccga ggacatcgct gccgctgttc agtgcggtct tgatgctggt      180

gtgcagatct cggcaaaggg tggtggtcac agttatggtt cttatgggtt tggtggtgag      240

gatggtcatt tgatgttgga gttggatcgt atgtaccgtg tgtcggttga tgatgataat      300

gtcgcgacta ttcagggtgg tgctcgtctt ggatacactg ctcttgagct tcttgaccag      360

ggtaaccgtg ccctgactca cggtacctgc cctgctgtcg gtatcggtgg ccacgttctc      420

ggtggcggct acgggtttgc tacccacacc cacggtctga ctctcgactg gctcgtcggt      480

gccaccgtcg tcctggccga tgcctccatc gtgcacgtct ccaagaccga gaacgcagat      540

ctcttctggg ccctccgcgg tggcggcggt ggtttcgcca tcgtctccga gttcgagttc      600

aacaccttcg aggctccgga gatcatcacc acctaccagg tcaccaccac ctggaaccgg      660

aaacagcacg ttgccggtct caaggctctc caggactggg ctgagaacac catgcccagg      720

gagctcagca tgcgtcttga gatcaacgcc aatgccctca attgggaggg taactacttc      780

ggtaacgcca aggatttgaa gaaggttctt cagcctatca tgaagaaggc tggtggcaag      840

tctaccatct ctaagcttgt tgagaccgat tggtatggcc agatcaacac ctacttgtac      900

ggtgctgacc tcaacattac ctacaactac gacgtccacg agtacttcta cgccaacagc      960

ttgaccgccc cccgcctctc cgatgaagcc atctccgcct tcgtcgacta caaattcgac     1020

aactcctccg tccgccccgg ccgcggctgg ttcatccaat gggacttcca cggcggcaag     1080

aactccgccc tcgcctccca ctccaacgac gagaccgcct acgcccaccg cgaccagctc     1140

tggctctggc agttctacga caacatctac gactacgaga acaacacctc tccctaccct     1200

gagagcgggt tcgagttcat gcagggtttt gtcgccacta ttgaagacac gcttcctgag     1260

gacaggaagg gcaagtactt caactatgct gatactacgc ttgataagga ggaggcgcag     1320

aagttgtact ggaggggtaa ccttgagaag ctgcaggcta tcaaggccaa gtatgaccct     1380

gaggatgtgt ttggtaatgt tgtctctgtt gagcccattg cctag                     1425


<210>  6
<211>  474
<212>  PRT
<213>  Acremonium strictum

<400>  6

Asn Ser Ile Asn Ala Cys Leu Ala Ala Ala Asp Val Glu Phe His Glu 
1               5                   10                  15      


Glu Asp Ser Glu Gly Trp Glu Met Asp Gly Thr Ala Phe Asn Leu Arg 
            20                  25                  30          


Val Asp Tyr Asp Pro Val Ala Ile Ala Ile Pro Arg Ser Thr Glu Asp 
        35                  40                  45              


Ile Ala Ala Ala Val Gln Cys Gly Leu Asp Ala Gly Val Gln Ile Ser 
    50                  55                  60                  


Ala Lys Gly Gly Gly His Ser Tyr Gly Ser Tyr Gly Phe Gly Gly Glu 
65                  70                  75                  80  


Asp Gly His Leu Met Leu Glu Leu Asp Arg Met Tyr Arg Val Ser Val 
                85                  90                  95      


Asp Asp Asp Asn Val Ala Thr Ile Gln Gly Gly Ala Arg Leu Gly Tyr 
            100                 105                 110         


Thr Ala Leu Glu Leu Leu Asp Gln Gly Asn Arg Ala Leu Thr His Gly 
        115                 120                 125             


Thr Cys Pro Ala Val Gly Ile Gly Gly His Val Leu Gly Gly Gly Tyr 
    130                 135                 140                 


Gly Phe Ala Thr His Thr His Gly Leu Thr Leu Asp Trp Leu Val Gly 
145                 150                 155                 160 


Ala Thr Val Val Leu Ala Asp Ala Ser Ile Val His Val Ser Lys Thr 
                165                 170                 175     


Glu Asn Ala Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Gly Gly Phe 
            180                 185                 190         


Ala Ile Val Ser Glu Phe Glu Phe Asn Thr Phe Glu Ala Pro Glu Ile 
        195                 200                 205             


Ile Thr Thr Tyr Gln Val Thr Thr Thr Trp Asn Arg Lys Gln His Val 
    210                 215                 220                 


Ala Gly Leu Lys Ala Leu Gln Asp Trp Ala Glu Asn Thr Met Pro Arg 
225                 230                 235                 240 


Glu Leu Ser Met Arg Leu Glu Ile Asn Ala Asn Ala Leu Asn Trp Glu 
                245                 250                 255     


Gly Asn Tyr Phe Gly Asn Ala Lys Asp Leu Lys Lys Val Leu Gln Pro 
            260                 265                 270         


Ile Met Lys Lys Ala Gly Gly Lys Ser Thr Ile Ser Lys Leu Val Glu 
        275                 280                 285             


Thr Asp Trp Tyr Gly Gln Ile Asn Thr Tyr Leu Ala Gly Ala Asp Leu 
    290                 295                 300                 


Asn Ile Thr Tyr Asn Tyr Asp Val His Glu Tyr Phe Tyr Ala Asn Ser 
305                 310                 315                 320 


Leu Thr Ala Pro Arg Leu Ser Asp Glu Ala Ile Ser Ala Phe Val Asp 
                325                 330                 335     


Tyr Lys Phe Asp Asn Ser Ser Val Arg Pro Gly Arg Gly Trp Trp Ile 
            340                 345                 350         


Gln Trp Asp Phe His Gly Gly Lys Asn Ser Ala Leu Ala Ser His Ser 
        355                 360                 365             


Asn Asp Glu Thr Ala Tyr Ala His Arg Asp Gln Leu Trp Leu Trp Gln 
    370                 375                 380                 


Phe Tyr Asp Asn Ile Tyr Asp Tyr Glu Asn Asn Thr Ser Pro Tyr Pro 
385                 390                 395                 400 


Glu Ser Gly Phe Glu Phe Met Gln Gly Phe Val Ala Thr Ile Glu Asp 
                405                 410                 415     


Thr Leu Pro Glu Asp Arg Lys Gly Lys Tyr Phe Asn Tyr Ala Asp Thr 
            420                 425                 430         


Thr Leu Asp Lys Glu Glu Ala Gln Lys Leu Tyr Trp Arg Gly Asn Leu 
        435                 440                 445             


Glu Lys Leu Gln Ala Ile Lys Ala Lys Tyr Asp Pro Glu Asp Val Phe 
    450                 455                 460                 


Gly Asn Val Val Ser Val Glu Pro Ile Ala 
465                 470                 


<210>  7
<211>  474
<212>  PRT
<213>  Acremonium strictum

<400>  7

Asn Ser Ile Asn Ala Cys Leu Ala Ala Ala Asp Val Glu Phe His Glu 
1               5                   10                  15      


Glu Asp Ser Glu Gly Trp Glu Met Asp Gly Thr Ala Phe Asn Leu Arg 
            20                  25                  30          


Val Asp Tyr Asp Pro Val Ala Ile Ala Ile Pro Arg Ser Thr Glu Asp 
        35                  40                  45              


Ile Ala Ala Ala Val Gln Cys Gly Leu Asp Ala Gly Val Gln Ile Ser 
    50                  55                  60                  


Ala Lys Gly Gly Gly His Ser Tyr Gly Ser Tyr Gly Phe Gly Gly Glu 
65                  70                  75                  80  


Asp Gly His Leu Met Leu Glu Leu Asp Arg Met Tyr Arg Val Ser Val 
                85                  90                  95      


Asp Asp Asp Asn Val Ala Thr Ile Gln Gly Gly Ala Arg Leu Gly Tyr 
            100                 105                 110         


Thr Ala Leu Glu Leu Leu Asp Gln Gly Asn Arg Ala Leu Thr His Gly 
        115                 120                 125             


Thr Cys Pro Ala Val Gly Ile Gly Gly His Val Leu Gly Gly Gly Tyr 
    130                 135                 140                 


Gly Phe Ala Thr His Thr His Gly Leu Thr Leu Asp Trp Leu Val Gly 
145                 150                 155                 160 


Ala Thr Val Val Leu Ala Asp Ala Ser Ile Val His Val Ser Lys Thr 
                165                 170                 175     


Glu Asn Ala Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Gly Gly Phe 
            180                 185                 190         


Ala Ile Val Ser Glu Phe Glu Phe Asn Thr Phe Glu Ala Pro Glu Ile 
        195                 200                 205             


Ile Thr Thr Tyr Gln Val Thr Thr Thr Trp Asn Arg Lys Gln His Val 
    210                 215                 220                 


Ala Gly Leu Lys Ala Leu Gln Asp Trp Ala Glu Asn Thr Met Pro Arg 
225                 230                 235                 240 


Glu Leu Ser Met Arg Leu Glu Ile Asn Ala Asn Ala Leu Asn Trp Glu 
                245                 250                 255     


Gly Asn Tyr Phe Gly Asn Ala Lys Asp Leu Lys Lys Val Leu Gln Pro 
            260                 265                 270         


Ile Met Lys Lys Ala Gly Gly Lys Ser Thr Ile Ser Lys Leu Val Glu 
        275                 280                 285             


Thr Asp Trp Tyr Gly Gln Ile Asn Thr Tyr Leu Asn Gly Ala Asp Leu 
    290                 295                 300                 


Asn Ile Thr Tyr Asn Tyr Asp Val His Glu Tyr Phe Tyr Ala Asn Ser 
305                 310                 315                 320 


Leu Thr Ala Pro Arg Leu Ser Asp Glu Ala Ile Ser Ala Phe Val Asp 
                325                 330                 335     


Tyr Lys Phe Asp Asn Ser Ser Val Arg Pro Gly Arg Gly Trp Trp Ile 
            340                 345                 350         


Gln Trp Asp Phe His Gly Gly Lys Asn Ser Ala Leu Ala Ser His Ser 
        355                 360                 365             


Asn Asp Glu Thr Ala Tyr Ala His Arg Asp Gln Leu Trp Leu Trp Gln 
    370                 375                 380                 


Phe Tyr Asp Asn Ile Tyr Asp Tyr Glu Asn Asn Thr Ser Pro Tyr Pro 
385                 390                 395                 400 


Glu Ser Gly Phe Glu Phe Met Gln Gly Phe Val Ala Thr Ile Glu Asp 
                405                 410                 415     


Thr Leu Pro Glu Asp Arg Lys Gly Lys Tyr Phe Asn Tyr Ala Asp Thr 
            420                 425                 430         


Thr Leu Asp Lys Glu Glu Ala Gln Lys Leu Tyr Trp Arg Gly Asn Leu 
        435                 440                 445             


Glu Lys Leu Gln Ala Ile Lys Ala Lys Tyr Asp Pro Glu Asp Val Phe 
    450                 455                 460                 


Gly Asn Val Val Ser Val Glu Pro Ile Ala 
465                 470                 


<210>  8
<211>  474
<212>  PRT
<213>  Acremonium strictum

<400>  8

Asn Ser Ile Asn Ala Cys Leu Ala Ala Ala Asp Val Glu Phe His Glu 
1               5                   10                  15      


Glu Asp Ser Glu Gly Trp Glu Met Asp Gly Thr Ala Phe Asn Leu Arg 
            20                  25                  30          


Val Asp Tyr Asp Pro Val Ala Ile Ala Ile Pro Arg Ser Thr Glu Asp 
        35                  40                  45              


Ile Ala Ala Ala Val Gln Cys Gly Leu Asp Ala Gly Val Gln Ile Ser 
    50                  55                  60                  


Ala Lys Gly Gly Gly His Ser Tyr Gly Ser Tyr Gly Phe Gly Gly Glu 
65                  70                  75                  80  


Asp Gly His Leu Met Leu Glu Leu Asp Arg Met Tyr Arg Val Ser Val 
                85                  90                  95      


Asp Asp Asp Asn Val Ala Thr Ile Gln Gly Gly Ala Arg Leu Gly Tyr 
            100                 105                 110         


Thr Ala Leu Glu Leu Leu Asp Gln Gly Asn Arg Ala Leu Thr His Gly 
        115                 120                 125             


Thr Cys Pro Ala Val Gly Ile Gly Gly His Val Leu Gly Gly Gly Tyr 
    130                 135                 140                 


Gly Phe Ala Thr His Thr His Gly Leu Thr Leu Asp Trp Leu Val Gly 
145                 150                 155                 160 


Ala Thr Val Val Leu Ala Asp Ala Ser Ile Val His Val Ser Lys Thr 
                165                 170                 175     


Glu Asn Ala Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Gly Gly Phe 
            180                 185                 190         


Ala Ile Val Ser Glu Phe Glu Phe Asn Thr Phe Glu Ala Pro Glu Ile 
        195                 200                 205             


Ile Thr Thr Tyr Gln Val Thr Thr Thr Trp Asn Arg Lys Gln His Val 
    210                 215                 220                 


Ala Gly Leu Lys Ala Leu Gln Asp Trp Ala Glu Asn Thr Met Pro Arg 
225                 230                 235                 240 


Glu Leu Ser Met Arg Leu Glu Ile Asn Ala Asn Ala Leu Asn Trp Glu 
                245                 250                 255     


Gly Asn Tyr Phe Gly Asn Ala Lys Asp Leu Lys Lys Val Leu Gln Pro 
            260                 265                 270         


Ile Met Lys Lys Ala Gly Gly Lys Ser Thr Ile Ser Lys Leu Val Glu 
        275                 280                 285             


Thr Asp Trp Tyr Gly Gln Ile Asn Thr Tyr Leu Tyr Gly Ala Asp Leu 
    290                 295                 300                 


Asn Ile Thr Tyr Asn Tyr Asp Val His Glu Tyr Phe Tyr Ala Asn Ser 
305                 310                 315                 320 


Leu Thr Ala Pro Arg Leu Ser Asp Glu Ala Ile Ser Ala Phe Val Asp 
                325                 330                 335     


Tyr Lys Phe Asp Asn Ser Ser Val Arg Pro Gly Arg Gly Trp Phe Ile 
            340                 345                 350         


Gln Trp Asp Phe His Gly Gly Lys Asn Ser Ala Leu Ala Ser His Ser 
        355                 360                 365             


Asn Asp Glu Thr Ala Tyr Ala His Arg Asp Gln Leu Trp Leu Trp Gln 
    370                 375                 380                 


Phe Tyr Asp Asn Ile Tyr Asp Tyr Glu Asn Asn Thr Ser Pro Tyr Pro 
385                 390                 395                 400 


Glu Ser Gly Phe Glu Phe Met Gln Gly Phe Val Ala Thr Ile Glu Asp 
                405                 410                 415     


Thr Leu Pro Glu Asp Arg Lys Gly Lys Tyr Phe Asn Tyr Ala Asp Thr 
            420                 425                 430         


Thr Leu Asp Lys Glu Glu Ala Gln Lys Leu Tyr Trp Arg Gly Asn Leu 
        435                 440                 445             


Glu Lys Leu Gln Ala Ile Lys Ala Lys Tyr Asp Pro Glu Asp Val Phe 
    450                 455                 460                 


Gly Asn Val Val Ser Val Glu Pro Ile Ala 
465                 470                 


