
                                SEQUENCE LISTING

<110> GLAXO GROUP LIMITED

      GERMASCHEWSKI, Fiona
      LARKIN, Jonathan
      LIU, Feng
      LOHR, Thomas


<120> Methods of Identifying a Patient Population
  

<130> PU64515

<140> Not Yet Assigned    
<141> 2012-02-24  

<150> 61/446,259          
<151> 2010-02-24  

<160> 159

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 1
Ala Arg Gly Ser Val Ile Leu
 1               5          


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 2
Asp Ala Trp Met Asp
 1               5  


<210> 3
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = Any Amino Acid

<400> 3
Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Xaa Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 4
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 4
Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp Val
 1               5                  10              


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 5
Pro Phe Ala Tyr
 1              


<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 6
Lys Ala Ser Gln Ser Val Gly Thr Thr Ile Val
 1               5                  10      


<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 7
Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala
 1               5                  10      


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 8
Asn Ala Lys Thr Leu Ala Glu
 1               5          


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Any Amino Acid

<400> 9
Ser Ala Ser Asn Arg Xaa Thr
 1               5          


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 10
Gln Gln Tyr Ser Ser Tyr Pro Phe Thr
 1               5                  


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 11
Gln His His Tyr Gly Thr Pro Trp Thr
 1               5                  


<210> 12
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 12
Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Ala Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 13
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 13
Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 14
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 14
Glu Ile Arg His Lys Ala Asn Asp Tyr Ala Ile Phe Tyr Asp Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 15
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 15
Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 16
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 16
Asp Ile Arg Asn Thr Ala Asn Asn His Ala Thr Phe Tyr Ala Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 17
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 17
Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 18
Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp Val
 1               5                  10              


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 19
Lys Ala Ser Gln Ser Val Gly Thr Thr Ile Val
 1               5                  10      


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 20
Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala
 1               5                  10      


<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 21
Lys Ala Ser Gln Asn Val Gly Thr Ala Val Val
 1               5                  10      


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 22
Asn Ala Lys Thr Leu Ala Glu
 1               5          


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 23
Ser Ala Ser Asn Arg His Thr
 1               5          


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 24
Ser Ala Ser Thr Arg Tyr Thr
 1               5          


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 25
Ser Ala Ser Asn Arg Tyr Thr
 1               5          


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 26
Gln Gln Tyr Ser Ser Tyr Pro Phe Thr
 1               5                  


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 27
Gln His His Tyr Gly Thr Pro Trp Thr
 1               5                  


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 28
Gln Gln Tyr Val Asn Tyr Pro Phe Thr
 1               5                  


<210> 29
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 29
Gln Gln Tyr Thr Ser Tyr Pro Phe Thr
 1               5                  


<210> 30
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<220> 
<221> VARIANT        
<222> 63
<223> Xaa = Any Amino Acid

<400> 30
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Xaa Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 31
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<220> 
<221> VARIANT        
<222> 55
<223> Xaa = Any Amino Acid

<400> 31
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Val Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg Xaa Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 32
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 32
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 33
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 33
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Gly Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 34
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 34
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asp Ile Arg Asn Thr Ala Asn Asn His Ala Thr Phe Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 35
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 35
Glu Val Lys Phe Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp Tyr Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 36
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 36
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 37
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 37
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 


<210> 38
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 38
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala
            20                  25                  30          
Val Val Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg Tyr Thr Arg Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Val Asn Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 39
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 39
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Val Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 40
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 40
Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Ser Val Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Thr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Gly Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 41
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 41
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Ser Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 42
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 42
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Val Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 43
<211> 930
<212> PRT
<213> Homo sapien

<400> 43
Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro
 1               5                  10                  15      
Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly
            20                  25                  30          
Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly
        35                  40                  45              
Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu
    50                  55                  60                  
Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu
65                  70                  75                  80  
Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg
                85                  90                  95      
Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly
            100                 105                 110         
Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser
        115                 120                 125             
His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala
    130                 135                 140                 
Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His
145                 150                 155                 160 
Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu
                165                 170                 175     
Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val
            180                 185                 190         
Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser
        195                 200                 205             
Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala
    210                 215                 220                 
His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp
225                 230                 235                 240 
Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp
                245                 250                 255     
Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu
            260                 265                 270         
Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln
        275                 280                 285             
His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His
    290                 295                 300                 
Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val
305                 310                 315                 320 
Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr
                325                 330                 335     
Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly
            340                 345                 350         
Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu
        355                 360                 365             
Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val
    370                 375                 380                 
Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp
385                 390                 395                 400 
Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu
                405                 410                 415     
Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser
            420                 425                 430         
Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala
        435                 440                 445             
Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu
    450                 455                 460                 
Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile
465                 470                 475                 480 
Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln
                485                 490                 495     
Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp
            500                 505                 510         
Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val
        515                 520                 525             
Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys
    530                 535                 540                 
Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys
545                 550                 555                 560 
Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp
                565                 570                 575     
Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg
            580                 585                 590         
His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly
        595                 600                 605             
Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn
    610                 615                 620                 
Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln
625                 630                 635                 640 
Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr
                645                 650                 655     
Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys
            660                 665                 670         
Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr
        675                 680                 685             
Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val
    690                 695                 700                 
Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys
705                 710                 715                 720 
Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly
                725                 730                 735     
Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro
            740                 745                 750         
Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln
        755                 760                 765             
Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr
    770                 775                 780                 
Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp
785                 790                 795                 800 
Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp
                805                 810                 815     
Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val
            820                 825                 830         
Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser
        835                 840                 845             
Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser
    850                 855                 860                 
His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val
865                 870                 875                 880 
Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His
                885                 890                 895     
Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly
            900                 905                 910         
Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys
        915                 920                 925             
Lys Cys
    930 


<210> 44
<211> 837
<212> PRT
<213> Homo sapien

<400> 44
Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp
 1               5                  10                  15      
Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser
            20                  25                  30          
Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser
        35                  40                  45              
Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro
    50                  55                  60                  
Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg
65                  70                  75                  80  
Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu
                85                  90                  95      
Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu
            100                 105                 110         
Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu
        115                 120                 125             
Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp
    130                 135                 140                 
Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu
145                 150                 155                 160 
His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro
                165                 170                 175     
Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro
            180                 185                 190         
Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg
        195                 200                 205             
Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val
    210                 215                 220                 
Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg
225                 230                 235                 240 
Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro
                245                 250                 255     
Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu
            260                 265                 270         
Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr
        275                 280                 285             
Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp
    290                 295                 300                 
Ser Gly Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp
305                 310                 315                 320 
Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly
                325                 330                 335     
Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly
            340                 345                 350         
Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn
        355                 360                 365             
Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu
    370                 375                 380                 
Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro
385                 390                 395                 400 
Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu
                405                 410                 415     
Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu
            420                 425                 430         
His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln
        435                 440                 445             
Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro
    450                 455                 460                 
Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala
465                 470                 475                 480 
Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly
                485                 490                 495     
Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu
            500                 505                 510         
Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro
        515                 520                 525             
Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser
    530                 535                 540                 
Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu
545                 550                 555                 560 
Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr
                565                 570                 575     
Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His
            580                 585                 590         
Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro
        595                 600                 605             
Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln
    610                 615                 620                 
Ala Arg Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp
625                 630                 635                 640 
Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg
                645                 650                 655     
Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe
            660                 665                 670         
Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln
        675                 680                 685             
Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr
    690                 695                 700                 
Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro
705                 710                 715                 720 
Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr
                725                 730                 735     
Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val
            740                 745                 750         
Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser
        755                 760                 765             
Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln
    770                 775                 780                 
Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe
785                 790                 795                 800 
Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp
                805                 810                 815     
Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro
            820                 825                 830         
Trp Ala Gly Arg Lys
        835         


<210> 45
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Signal sequence

<400> 45
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcacagc    57

<210> 46
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Signal sequence

<400> 46
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 47
<211> 372
<212> DNA
<213> Murine

<400> 47
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc 60
tcttgtgctg cctctggatt cacttctagt gacgcctgga tggactgggt ccgccagtct 120
ccagaaaagg ggcttgagtg ggttgctgaa attagaaaca aagctaataa tcatgcaaga 180
cactatgctg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt 240
gtctacctgc aaatgaacag cttaagagct gaagactctg gcatttatta ctgtaccagg 300
acgtattatt acggtagcag ctacggatac tgcgatgtct ggggcacagg gaccacggtc 360
accgtctcct ca                                                     372

<210> 48
<211> 124
<212> PRT
<213> Murine

<400> 48
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 


<210> 49
<211> 327
<212> DNA
<213> Murine

<400> 49
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc 60
atcacatgtc gaacaagtga gaatatttac agttatttag catggtatca gcagaaacag 120
ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca 180
aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct 240
gaagattttg ggagttattc ctgtcaacat cattatggta ctccgtggac gttcggtgga 300
ggcaccaagc tggaaatcaa acgggct                                     327

<210> 50
<211> 109
<212> PRT
<213> Murine

<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Ser Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 51
<211> 345
<212> DNA
<213> Murine

<400> 51
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc 60
tcctgtactg cctccggatt cacttttagt gacgcctgga tggactgggt ccgccagtct 120
ccagagaagg gacttgagtg ggttgctgaa attagacaca aagctaatga tcatgcaata 180
ttttatgatg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaaatatt 240
gtctatctgc aaatgaacag tttaagacct gaggacaccg gcatttatta ttgtaccagt 300
ccttttgctt attggggcca agggactctg gtcactgtct ctgca                 345

<210> 52
<211> 115
<212> PRT
<213> Murine

<400> 52
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 53
<211> 327
<212> DNA
<213> Murine

<400> 53
gacattgtga tgacccagtc tcaaaaattc atgtccgtaa cagtgggaga cagggtcagc 60
atcacctgca aggccagtca gagtgtggga actactatag tctggtatca acagaaacca 120
ggacaatctc ctaaattact gatttactct gcatccaatc ggcacactgg ggtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcattctca ccattaacaa tgtgcagtct 240
gaggacctgg cagattattt ctgtcagcaa tatacctcct atccattcac gttcggctcg 300
gggacaaagt tggagataaa acgggct                                     327

<210> 54
<211> 109
<212> PRT
<213> Murine

<400> 54
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Val Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala
            100                 105                 


<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 55
Asp Ala Trp Met Asp
 1               5  


<210> 56
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 56
Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 57
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 57
Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp Val
 1               5                  10              


<210> 58
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 58
Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala
 1               5                  10      


<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 59
Asn Ala Lys Thr Leu Ala Glu
 1               5          


<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 60
Gln His His Tyr Gly Thr Pro Trp Thr
 1               5                  


<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 61
Asp Ala Trp Met Asp
 1               5  


<210> 62
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 62
Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 63
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 63
Pro Phe Ala Tyr
 1              


<210> 64
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 64
Lys Ala Ser Gln Ser Val Gly Thr Thr Ile Val
 1               5                  10      


<210> 65
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 65
Ser Ala Ser Asn Arg His Thr
 1               5          


<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 66
Gln Gln Tyr Thr Ser Tyr Pro Phe Thr
 1               5                  


<210> 67
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 67
gaggtgaagc tggaggaatc aggaggcgga ctggtgcagc ccggcggcag catgaaactg 60
agctgcgctg cctctggctt caccagctct gacgcctgga tggattgggt gaggcagagc 120
cccgagaagg gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa gggcaggttc accatcagca gggacgacag caagagctcc 240
gtgtacctgc agatgaacag cctccgggcc gaggacagcg gcatctacta ctgcaccagg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggaaccgg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 68
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 68
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Thr Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 69
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 69
gacatccaga tgacccagag ccccgccagc ctgagcgcaa gcgtgggcga gaccgtcacc 60
atcacctgca ggaccagcga gaacatctac agctacctgg cctggtatca gcagaagcag 120
ggcaagagcc cccagctgct ggtgtacaac gccaaaaccc tggccgaagg cgtgccctct 180
aggttcagcg gaagcggaag cggcacccag ttcagcctca agatcaactc cctgcagccc 240
gaggacttcg gcagctacag ctgccagcac cactacggca ctccctggac ctttggcggc 300
ggcaccaagc tggagattaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 70
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 70
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Ser Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 71
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 71
gaggtgaaac tggaggaaag cggcggcgga ctggtgcagc ccggcggctc aatgaagctg 60
agctgcaccg ccagcggctt caccttctct gacgcctgga tggactgggt gaggcagagc 120
cccgagaagg gcctggagtg ggtggctgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatcagca gggacgacag caagaacatc 240
gtgtacctcc agatgaacag cctgaggccc gaggataccg gcatctacta ctgcaccagc 300
ccctttgcct attggggcca gggcacacta gtgaccgtgt ccagcgccag caccaagggc 360
cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgccctg 420
ggctgcctgg tgaaggacta cttccccgaa ccggtgaccg tgtcctggaa cagcggagcc 480
ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg 540
agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgtaacgtg 600
aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgtgacaag 660
acccacacct gccccccctg ccctgccccc gagctgctgg gaggccccag cgtgttcctg 720
ttccccccca agcctaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg 780
gtggtggatg tgagccacga ggaccctgag gtgaagttca actggtacgt ggacggcgtg 840
gaggtgcaca atgccaagac caagcccagg gaggagcagt acaacagcac ctaccgggtg 900
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaggagta caagtgtaag 960
gtgtccaaca aggccctgcc tgcccctatc gagaaaacca tcagcaaggc caagggccag 1020
cccagagagc cccaggtgta caccctgccc cctagcagag atgagctgac caagaaccag 1080
gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgatggc 1200
agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg 1260
ttcagctgct ccgtgatgca cgaggccctg cacaatcact acacccagaa gagcctgagc 1320
ctgtcccctg gcaag                                                  1335

<210> 72
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 72
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 73
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 73
gacatcgtga tgacccagag ccagaaattc atgagcgtga ccgtgggcga cagggtgtcc 60
atcacttgca aggccagcca gagcgtgggc accactatcg tgtggtacca gcagaagccc 120
ggccagagcc ccaagctcct gatctacagc gccagcaaca ggcacaccgg agtgcccgac 180
aggtttactg gcagcggctc aggcaccgac ttcatcctga ccatcaacaa cgtgcagagc 240
gaggacctgg ccgattactt ctgccagcag tacaccagct accccttcac cttcggctca 300
gggaccaagc tggagattaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 74
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 74
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Val Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 75
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 75
gaggtgaagc tggaggaatc aggaggcgga ctggtgcagc ccggcggcag catgaaactg 60
agctgcgctg cctctggctt caccagctct gacgcctgga tggattgggt gaggcagagc 120
cccgagaagg gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa gggcaggttc accatcagca gggacgacag caagagctcc 240
gtgtacctgc agatgaacag cctccgggcc gaggacagcg gcatctacta ctgcaccagg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggaaccgg cacactagtc 360
accgtgagca gc                                                     372

<210> 76
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 76
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Thr Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 77
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 77
gacatccaga tgacccagag ccccgccagc ctgagcgcaa gcgtgggcga gaccgtcacc 60
atcacctgca ggaccagcga gaacatctac agctacctgg cctggtatca gcagaagcag 120
ggcaagagcc cccagctgct ggtgtacaac gccaaaaccc tggccgaagg cgtgccctct 180
aggttcagcg gaagcggaag cggcacccag ttcagcctca agatcaactc cctgcagccc 240
gaggacttcg gcagctacag ctgccagcac cactacggca ctccctggac ctttggcggc 300
ggcaccaagc tggagattaa gcgtacg                                     327

<210> 78
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 78
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Ser Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 79
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 79
gaggtgaaac tggaggaaag cggcggcgga ctggtgcagc ccggcggctc aatgaagctg 60
agctgcaccg ccagcggctt caccttctct gacgcctgga tggactgggt gaggcagagc 120
cccgagaagg gcctggagtg ggtggctgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatcagca gggacgacag caagaacatc 240
gtgtacctcc agatgaacag cctgaggccc gaggataccg gcatctacta ctgcaccagc 300
ccctttgcct attggggcca gggcacacta gtcaccgtgt ccagc                 345

<210> 80
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 80
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Gly Ile Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 81
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 81
gacatcgtga tgacccagag ccagaaattc atgagcgtga ccgtgggcga cagggtgtcc 60
atcacttgca aggccagcca gagcgtgggc accactatcg tgtggtacca gcagaagccc 120
ggccagagcc ccaagctcct gatctacagc gccagcaaca ggcacaccgg agtgcccgac 180
aggtttactg gcagcggctc aggcaccgac ttcatcctga ccatcaacaa cgtgcagagc 240
gaggacctgg ccgattactt ctgccagcag tacaccagct accccttcac cttcggctca 300
gggaccaagc tggagattaa gcgtacg                                     327

<210> 82
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 82
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Val Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 83
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 83
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcgcccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 84
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 84
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 85
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 85
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 86
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 86
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 87
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 87
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcgcccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 88
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 88
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 89
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 89
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 90
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 90
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 91
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 91
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacgacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 92
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 93
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 93
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
gtctacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 94
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 94
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 95
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 95
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacgacgc caagaacagc 240
gtctacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gcgccagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag 420
agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgaaccg 480
gtgaccgtgt cctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg 540
ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg 600
ggcacccaga cctacatctg taacgtgaac cacaagccca gcaacaccaa ggtggacaag 660
aaggtggagc ccaagagctg tgacaagacc cacacctgcc ccccctgccc tgcccccgag 720
ctgctgggag gccccagcgt gttcctgttc ccccccaagc ctaaggacac cctgatgatc 780
agcagaaccc ccgaggtgac ctgtgtggtg gtggatgtga gccacgagga ccctgaggtg 840
aagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag 900
gagcagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggattgg 960
ctgaacggca aggagtacaa gtgtaaggtg tccaacaagg ccctgcctgc ccctatcgag 1020
aaaaccatca gcaaggccaa gggccagccc agagagcccc aggtgtacac cctgccccct 1080
agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac 1140
cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200
accccccctg tgctggacag cgatggcagc ttcttcctgt acagcaagct gaccgtggac 1260
aagagcagat ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1320
aatcactaca cccagaagag cctgagcctg tcccctggca ag                    1362

<210> 96
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 96
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 97
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 97
gacatccaga tgacccagag ccccagcagc ctgagcgcta gcgtgggcga cagggtgacc 60
atcacctgca ggacctccga gaacatctac agctacctgg cctggtatca gcagaaaccc 120
ggcaaggccc ccaagctcct gatctacaac gccaagacac tggccgaggg cgtgcccagc 180
aggttctcag gcagcggctc tgggaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggaa ccccctggac cttcggccag 300
ggcaccaagc tggagattaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 98
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 98
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 99
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 99
gacatccaga tgacccagag ccccagcagc ctgagcgcta gcgtgggcga cagggtgacc 60
atcacctgca ggacctccga gaacatctac agctacctgg cctggtatca gcagaaaccc 120
ggcaaggccc ccaagctcct ggtgtacaac gccaagacac tggccgaggg cgtgcccagc 180
aggttctcag gcagcggctc tgggaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggaa ccccctggac cttcggccag 300
ggcaccaagc tggagattaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 100
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 100
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 101
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 101
gacatccaga tgacccagag ccccagcagc ctgagcgcta gcgtgggcga cagggtgacc 60
atcacctgca ggacctccga gaacatctac agctacctgg cctggtatca gcagaaaccc 120
ggcaaggccc cccagctcct ggtgtacaac gccaagacac tggccgaggg cgtgcccagc 180
aggttctcag gcagcggctc tgggaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggaa ccccctggac cttcggccag 300
ggcaccaagc tggagattaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 102
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 102
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 103
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 103
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcagcgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacaacag caagaacacc 240
ctgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcgccaag 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagcgccag caccaagggc 360
cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgccctg 420
ggctgcctgg tgaaggacta cttccccgaa ccggtgaccg tgtcctggaa cagcggagcc 480
ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg 540
agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgtaacgtg 600
aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgtgacaag 660
acccacacct gccccccctg ccctgccccc gagctgctgg gaggccccag cgtgttcctg 720
ttccccccca agcctaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg 780
gtggtggatg tgagccacga ggaccctgag gtgaagttca actggtacgt ggacggcgtg 840
gaggtgcaca atgccaagac caagcccagg gaggagcagt acaacagcac ctaccgggtg 900
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaggagta caagtgtaag 960
gtgtccaaca aggccctgcc tgcccctatc gagaaaacca tcagcaaggc caagggccag 1020
cccagagagc cccaggtgta caccctgccc cctagcagag atgagctgac caagaaccag 1080
gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgatggc 1200
agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg 1260
ttcagctgct ccgtgatgca cgaggccctg cacaatcact acacccagaa gagcctgagc 1320
ctgtcccctg gcaag                                                  1335

<210> 104
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 104
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 105
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 105
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcagcgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacaacag caagaacacc 240
ctgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagcgccag caccaagggc 360
cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgccctg 420
ggctgcctgg tgaaggacta cttccccgaa ccggtgaccg tgtcctggaa cagcggagcc 480
ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg 540
agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgtaacgtg 600
aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgtgacaag 660
acccacacct gccccccctg ccctgccccc gagctgctgg gaggccccag cgtgttcctg 720
ttccccccca agcctaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg 780
gtggtggatg tgagccacga ggaccctgag gtgaagttca actggtacgt ggacggcgtg 840
gaggtgcaca atgccaagac caagcccagg gaggagcagt acaacagcac ctaccgggtg 900
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaggagta caagtgtaag 960
gtgtccaaca aggccctgcc tgcccctatc gagaaaacca tcagcaaggc caagggccag 1020
cccagagagc cccaggtgta caccctgccc cctagcagag atgagctgac caagaaccag 1080
gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgatggc 1200
agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg 1260
ttcagctgct ccgtgatgca cgaggccctg cacaatcact acacccagaa gagcctgagc 1320
ctgtcccctg gcaag                                                  1335

<210> 106
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 106
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 107
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 107
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcagcgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacgacag caagaacacc 240
ctgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagcgccag caccaagggc 360
cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgccctg 420
ggctgcctgg tgaaggacta cttccccgaa ccggtgaccg tgtcctggaa cagcggagcc 480
ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg 540
agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgtaacgtg 600
aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgtgacaag 660
acccacacct gccccccctg ccctgccccc gagctgctgg gaggccccag cgtgttcctg 720
ttccccccca agcctaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg 780
gtggtggatg tgagccacga ggaccctgag gtgaagttca actggtacgt ggacggcgtg 840
gaggtgcaca atgccaagac caagcccagg gaggagcagt acaacagcac ctaccgggtg 900
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaggagta caagtgtaag 960
gtgtccaaca aggccctgcc tgcccctatc gagaaaacca tcagcaaggc caagggccag 1020
cccagagagc cccaggtgta caccctgccc cctagcagag atgagctgac caagaaccag 1080
gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgatggc 1200
agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg 1260
ttcagctgct ccgtgatgca cgaggccctg cacaatcact acacccagaa gagcctgagc 1320
ctgtcccctg gcaag                                                  1335

<210> 108
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 108
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 109
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 109
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcgccgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacaacag caagaacacc 240
gtgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagcgccag caccaagggc 360
cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgccctg 420
ggctgcctgg tgaaggacta cttccccgaa ccggtgaccg tgtcctggaa cagcggagcc 480
ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg 540
agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgtaacgtg 600
aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgtgacaag 660
acccacacct gccccccctg ccctgccccc gagctgctgg gaggccccag cgtgttcctg 720
ttccccccca agcctaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg 780
gtggtggatg tgagccacga ggaccctgag gtgaagttca actggtacgt ggacggcgtg 840
gaggtgcaca atgccaagac caagcccagg gaggagcagt acaacagcac ctaccgggtg 900
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaggagta caagtgtaag 960
gtgtccaaca aggccctgcc tgcccctatc gagaaaacca tcagcaaggc caagggccag 1020
cccagagagc cccaggtgta caccctgccc cctagcagag atgagctgac caagaaccag 1080
gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgatggc 1200
agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg 1260
ttcagctgct ccgtgatgca cgaggccctg cacaatcact acacccagaa gagcctgagc 1320
ctgtcccctg gcaag                                                  1335

<210> 110
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 110
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 111
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 111
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcgccgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacgacag caagaacacc 240
gtgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagcgccag caccaagggc 360
cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgccctg 420
ggctgcctgg tgaaggacta cttccccgaa ccggtgaccg tgtcctggaa cagcggagcc 480
ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg 540
agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgtaacgtg 600
aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgtgacaag 660
acccacacct gccccccctg ccctgccccc gagctgctgg gaggccccag cgtgttcctg 720
ttccccccca agcctaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg 780
gtggtggatg tgagccacga ggaccctgag gtgaagttca actggtacgt ggacggcgtg 840
gaggtgcaca atgccaagac caagcccagg gaggagcagt acaacagcac ctaccgggtg 900
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaggagta caagtgtaag 960
gtgtccaaca aggccctgcc tgcccctatc gagaaaacca tcagcaaggc caagggccag 1020
cccagagagc cccaggtgta caccctgccc cctagcagag atgagctgac caagaaccag 1080
gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgatggc 1200
agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg 1260
ttcagctgct ccgtgatgca cgaggccctg cacaatcact acacccagaa gagcctgagc 1320
ctgtcccctg gcaag                                                  1335

<210> 112
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 112
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 113
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 113
gacatccaga tgacccagag cccctcaagc ctgtctgcca gcgtgggcga cagggtgacc 60
attacctgca aggccagcca gagcgtcggc accaccatcg tgtggtacca gcagaaaccc 120
ggcaaggccc ccaagctcct gatctacagc gccagcaaca ggcacaccgg cgtgcctagc 180
aggtttagcg gaagcggcag cggcaccgac ttcaccctga caatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcag tacaccagct atcccttcac cttcggccag 300
ggcaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 114
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 114
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 115
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 115
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcgcccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gc                                                     372

<210> 116
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 116
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 117
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 117
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gc                                                     372

<210> 118
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 118
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 119
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 119
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcgcccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gc                                                     372

<210> 120
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 120
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 121
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 121
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gc                                                     372

<210> 122
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 122
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 123
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 123
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacgacgc caagaacagc 240
ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gc                                                     372

<210> 124
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 124
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 125
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 125
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacaacgc caagaacagc 240
gtctacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gc                                                     372

<210> 126
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 126
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 127
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 127
gaggtgcagc tggtcgaaag cggcggcggc ctggtgcagc ccggaggcag cctcaggctg 60
tcttgcgctg cctccggctt caccagcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gcctggagtg ggtggccgag atcaggaaca aggccaacaa ccacgccagg 180
cactacgccg agagcgtgaa ggggaggttc accatcagca gggacgacgc caagaacagc 240
gtctacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcacccgg 300
acctactact acgggagcag ctacggctat tgcgacgtgt ggggccaggg cacactagtg 360
accgtgtcca gc                                                     372

<210> 128
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 128
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Arg His Tyr Ala Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Arg Thr Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Cys Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 129
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 129
gacatccaga tgacccagag ccccagcagc ctgagcgcta gcgtgggcga cagggtgacc 60
atcacctgca ggacctccga gaacatctac agctacctgg cctggtatca gcagaaaccc 120
ggcaaggccc ccaagctcct gatctacaac gccaagacac tggccgaggg cgtgcccagc 180
aggttctcag gcagcggctc tgggaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggaa ccccctggac cttcggccag 300
ggcaccaagc tggagattaa gcgtacg                                     327

<210> 130
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 130
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 131
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 131
gacatccaga tgacccagag ccccagcagc ctgagcgcta gcgtgggcga cagggtgacc 60
atcacctgca ggacctccga gaacatctac agctacctgg cctggtatca gcagaaaccc 120
ggcaaggccc ccaagctcct ggtgtacaac gccaagacac tggccgaggg cgtgcccagc 180
aggttctcag gcagcggctc tgggaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggaa ccccctggac cttcggccag 300
ggcaccaagc tggagattaa gcgtacg                                     327

<210> 132
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 132
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 133
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 133
gacatccaga tgacccagag ccccagcagc ctgagcgcta gcgtgggcga cagggtgacc 60
atcacctgca ggacctccga gaacatctac agctacctgg cctggtatca gcagaaaccc 120
ggcaaggccc cccagctcct ggtgtacaac gccaagacac tggccgaggg cgtgcccagc 180
aggttctcag gcagcggctc tgggaccgac ttcaccctga ccatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcac cactacggaa ccccctggac cttcggccag 300
ggcaccaagc tggagattaa gcgtacg                                     327

<210> 134
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 134
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 135
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 135
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcagcgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacaacag caagaacacc 240
ctgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcgccaag 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagc                 345

<210> 136
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 136
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 137
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 137
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcagcgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacaacag caagaacacc 240
ctgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagc                 345

<210> 138
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 138
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 139
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 139
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcagcgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacgacag caagaacacc 240
ctgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagc                 345

<210> 140
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 140
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 141
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 141
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcgccgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacaacag caagaacacc 240
gtgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagc                 345

<210> 142
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 142
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 143
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 143
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcgccgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacgacag caagaacacc 240
gtgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagc                 345

<210> 144
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 144
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 145
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 145
gacatccaga tgacccagag cccctcaagc ctgtctgcca gcgtgggcga cagggtgacc 60
attacctgca aggccagcca gagcgtcggc accaccatcg tgtggtacca gcagaaaccc 120
ggcaaggccc ccaagctcct gatctacagc gccagcaaca ggcacaccgg cgtgcctagc 180
aggtttagcg gaagcggcag cggcaccgac ttcaccctga caatcagcag cctgcagccc 240
gaggacttcg ccacctacta ctgccagcag tacaccagct atcccttcac cttcggccag 300
ggcaccaagc tggagatcaa gcgtacg                                     327

<210> 146
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 146
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Thr Thr
            20                  25                  30          
Ile Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Tyr Pro Phe
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr
            100                 105                 


<210> 147
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 147
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc 60
tcctgtactg cctccggatt cacttttagt gacgcctgga tggactgggt ccgccagtct 120
ccagagaagg gacttgagtg ggttgctgaa attagacaca aagctaatga tcatgcaata 180
ttttatgatg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaaatatt 240
gtctatctgc aaatgaacag tttaagacct gaggacaccg gcatttatta ttgtaccagt 300
ccttttgctt attggggcca agggactctg gtcactgtct ctgca                 345

<210> 148
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 148
gacattgtga tgacccagtc tcaaaaattc atgtccgtaa cagtgggaga cagggtcagc 60
atcacctgca aggccagtca gagtgtggga actactatag tctggtatca acagaaacca 120
ggacaatctc ctaaattact gatttactct gcatccaatc ggcacactgg ggtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcattctca ccattaacaa tgtgcagtct 240
gaggacctgg cagattattt ctgtcagcaa tatacctcct atccattcac gttcggctcg 300
gggacaaagt tggagataaa acgggct                                     327

<210> 149
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 149
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc 60
tcttgtgctg cctctggatt cacttctagt gacgcctgga tggactgggt ccgccagtct 120
ccagaaaagg ggcttgagtg ggttgctgaa attagaaaca aagctaataa tcatgcaaga 180
cactatgctg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt 240
gtctacctgc aaatgaacag cttaagagct gaagactctg gcatttatta ctgtaccagg 300
acgtattatt acggtagcag ctacggatac tgcgatgtct ggggcacagg gaccacggtc 360
accgtctcct ca                                                     372

<210> 150
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 150
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc 60
atcacatgtc gaacaagtga gaatatttac agttatttag catggtatca gcagaaacag 120
ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca 180
aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct 240
gaagattttg ggagttattc ctgtcaacat cattatggta ctccgtggac gttcggtgga 300
ggcaccaagc tggaaatcaa acgggct                                     327

<210> 151
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 151
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc 60
tcttgtgctg cctctggaat cacttttagt gatgcctgga tggactgggt ccgccagtct 120
ccagagaagg ggcttgagtg ggttgctgac attagaaaca cagctaataa tcatgcaaca 180
ttctatgctg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtact 240
gtctacctgc aaatgaacac cttaagacct gaagacactg gcatttatta ctgtaccagc 300
ccttttgctt actggggcca agggactctg gtcactgtct ctgca                 345

<210> 152
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 152
gacattgtga tgacccagtc tcaaaaattc atgtccacaa cagtaggaga cagggtcagc 60
atcacctgca aggccagtca aaatgtgggt actgctgtag tctggtttca acagaaacca 120
ggacaatctc ctaaactact gatttactca gcatccaatc ggtacaccag agtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct 240
gaagacctgg cagattattt ctgtcagcaa tatgtcaact atccattcac gttcggctcg 300
gggacaaaat tggaaataaa acgggct                                     327

<210> 153
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 153
gaagtgaagt ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc 60
tcctgtgctg cctccggatt tatttttagt gacgcctgga tggactgggt ccgccagtct 120
ccagagaagg gacttgagtg ggttgctgaa attagacaca aagctaatga ttatgcaata 180
ttttatgatg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtatt 240
gtctatctgc aaatgaacaa cttaagacct gaagacaccg gcatttatta ttgtaccagt 300
ccttttgctt actggggcca agggactctg gtcactgtct ctgca                 345

<210> 154
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 154
gacattgtga tgacccagtc tcaaaaattc atgtccgtaa cagtgggaga cagggtcagc 60
atcacctgca aggccagtca gagtgtggga actactatag tctggtatca acagaaacca 120
ggacaatctc ctaaattact gatttactca gcatccaatc gacacactgg agtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcattctca ccattagcaa tgtgcagtct 240
gaagacctgg cagattattt ctgtcagcaa tatagcagct atccattcac gttcggctcg 300
gggacaaagt tggaaataaa acgggct                                     327

<210> 155
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 155
gaggtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc 60
tcctgtgctg cctctggatt cacttttagt gacgcctgga tggactgggt ccgccagtct 120
ccagagaagg gacttgagtg ggttgctgaa attagacaca aagctaatga tcatgcaata 180
ttttatgatg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtatt 240
gtctatctgc aaatgaacag cttaagacct gaagacaccg gcatttatta ttgtaccagt 300
ccttttgctt actggggcca agggactctg gtcactgtct ctgca                 345

<210> 156
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Light chain

<400> 156
gacattgtga tgacccagtc tcaaagattc atgtccgtaa cagtgggaga cagggtcagc 60
atcacctgca aggccagtca gagtgtgggt actactatag tctggtatca acagaaacca 120
ggacaatctc ctaaactact gatttactca gcatccactc ggtatactgg ggtccctgat 180
cgcttcacag gcggtggatc tgggacagat ttcattctca ccattaacaa tgtgcagtct 240
gaagacctgg cagattattt ctgtcagcag tatagcagct atccattcac gttcggctcg 300
gggacaaagt tggaaataaa acgggct                                     327

<210> 157
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 157
gaagtgaagc ttgaggagtc tggaggaggc ttggggcaac ctggaggatc catgaaactc 60
tcttgtgctg cctctggatt caattttagt gacgcctgga tggactgggt ccgccagtct 120
ccagaaaagg ggcttgagtg ggttgctgaa attagacaca aagctaatga tcatgcaata 180
ttctatgctg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt 240
gtctacctcc aaatgaacag cttaagagct gaagacactg gcatttatta ctgtaccagc 300
ccttttgctt actggggcca agggactctg gtcactgtct ctgca                 345

<210> 158
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 158
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30          
Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Arg His Lys Ala Asn Asp His Ala Ile Phe Tyr Asp Glu
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Thr Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 159
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Heavy chain

<400> 159
gaggtgcagc tcctggagag cggcgggggc ctggtgcagc ccggcggcag cctgagactg 60
agctgcgccg caagcggctt caccttcagc gacgcctgga tggattgggt gaggcaggcc 120
cccggcaaag gactggagtg ggtcgccgag atcaggcaca aggccaacga ccacgccatc 180
ttctacgacg agagcgtgaa gggcaggttc accatctcca gggacgacag caagaacacc 240
gtgtacctgc agatgaacag cctgagggcc gaagacaccg ctgtgtacta ctgcaccagc 300
ccctttgcct actggggcca gggaacacta gtgaccgtgt ccagcgccag caccaagggc 360
cccagcgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgccctg 420
ggctgcctgg tgaaggacta cttccccgaa ccggtgaccg tgtcctggaa cagcggagcc 480
ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg 540
agcagcgtgg tgaccgtgcc cagcagcagc ctgggcaccc agacctacat ctgtaacgtg 600
aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgtgacaag 660
acccacacct gccccccctg ccctgccccc gagctggccg gagcccccag cgtgttcctg 720
ttccccccca agcctaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg 780
gtggtggatg tgagccacga ggaccctgag gtgaagttca actggtacgt ggacggcgtg 840
gaggtgcaca atgccaagac caagcccagg gaggagcagt acaacagcac ctaccgggtg 900
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaggagta caagtgtaag 960
gtgtccaaca aggccctgcc tgcccctatc gagaaaacca tcagcaaggc caagggccag 1020
cccagagagc cccaggtgta caccctgccc cctagcagag atgagctgac caagaaccag 1080
gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgatggc 1200
agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg 1260
ttcagctgct ccgtgatgca cgaggccctg cacaatcact acacccagaa gagcctgagc 1320
ctgtcccctg gcaag                                                  1335
