
                                SEQUENCE LISTING

<110> Bobrowicz, Piotr
      Cook, William J.
      Hamilton, Stephen
      Nett, Juergen
      Stadheim, Terrance A.
      Wildt, Stefan

<120> Yeast Strain for the Production of
  Proteins with Modified O-Glycosylation
  

<130> GFI-BIO-0033

<150> US 61/446,846
<151> 2011-02-25

<160> 144

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 111
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScGLS1-s ER/Golgi Transmembrane Domain

<400> 1
atgcttattt caaaatctaa gatgtttaaa acattttgga tactaaccag catagttctc 60
ctggcatctg ccaccgttga tattagtaaa ctacaagaat tcgggcgcgc c          111

<210> 2
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScGLS1-s ER/Golgi Transmembrane Domain

<400> 2
Met Leu Ile Ser Lys Ser Lys Met Phe Lys Thr Phe Trp Ile Leu Thr
 1               5                  10                  15      
Ser Ile Val Leu Leu Ala Ser Ala Thr Val Asp Ile Ser Lys Leu Gln
            20                  25                  30          
Glu Phe Gly Arg Ala
        35          


<210> 3
<211> 99
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNS1-s ER/Golgi Transmembrane Domain

<400> 3
atgaagaact ctgtcggtat ttcaattgca accattgttg ctatcatagc agctatatac 60
tatgtgccat ggtacgaaca ctttgagaga gggcgcgcc                        99

<210> 4
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNS1-s ER/Golgi Transmembrane Domain

<400> 4
Met Lys Asn Ser Val Gly Ile Ser Ile Ala Thr Ile Val Ala Ile Ile
 1               5                  10                  15      
Ala Ala Ile Tyr Tyr Val Pro Trp Tyr Glu His Phe Glu Arg Gly Arg
            20                  25                  30          
Ala
    


<210> 5
<211> 255
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNS1-m ER/Golgi Transmembrane Domain

<400> 5
atgaagaact ctgtcggtat ttcaattgca accattgttg ctatcatagc agctatatac 60
tatgtgccat ggtacgaaca ctttgagaga aagtcaccgg gggccggaga aatgagagat 120
cggattgaaa gcatgttctt ggaatcgtgg agagactatt ccaagcatgg ctggggatac 180
gatgtgtatg gacctattga gcacacttcc cataatatgc ctcgtggcaa ccagccgtta 240
ggctgggggc gcgcc                                                  255

<210> 6
<211> 85
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNS1-m ER/Golgi Transmembrane Domain

<400> 6
Met Lys Asn Ser Val Gly Ile Ser Ile Ala Thr Ile Val Ala Ile Ile
 1               5                  10                  15      
Ala Ala Ile Tyr Tyr Val Pro Trp Tyr Glu His Phe Glu Arg Lys Ser
            20                  25                  30          
Pro Gly Ala Gly Glu Met Arg Asp Arg Ile Glu Ser Met Phe Leu Glu
        35                  40                  45              
Ser Trp Arg Asp Tyr Ser Lys His Gly Trp Gly Tyr Asp Val Tyr Gly
    50                  55                  60                  
Pro Ile Glu His Thr Ser His Asn Met Pro Arg Gly Asn Gln Pro Leu
65                  70                  75                  80  
Gly Trp Gly Arg Ala
                85  


<210> 7
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScSEC12-m ER/Golgi Transmembrane Domain

<400> 7
atgaacacta tccacataat aaaattaccg cttaactacg ccaactacac ctcaatgaaa 60
caaaaaatct ctaaattttt caccaacttc atccttattg tgctgctttc ttacatttta 120
cagttctcct ataagcacaa tttgcattcc atgcttttca attacgcgaa ggacaatttt 180
ctaacgaaaa gagacaccat ctcttcgccc tacgtagttg atgaagactt acatcaaaca 240
actttgtttg gcaaccacgg tacaaaaaca tctgtaccta gcgtagattc cataaaagtg 300
catggcgtgg ggcgcgcc                                               318

<210> 8
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScSEC12-m ER/Golgi Transmembrane Domain

<400> 8
Met Asn Thr Ile His Ile Ile Lys Leu Pro Leu Asn Tyr Ala Asn Tyr
 1               5                  10                  15      
Thr Ser Met Lys Gln Lys Ile Ser Lys Phe Phe Thr Asn Phe Ile Leu
            20                  25                  30          
Ile Val Leu Leu Ser Tyr Ile Leu Gln Phe Ser Tyr Lys His Asn Leu
        35                  40                  45              
His Ser Met Leu Phe Asn Tyr Ala Lys Asp Asn Phe Leu Thr Lys Arg
    50                  55                  60                  
Asp Thr Ile Ser Ser Pro Tyr Val Val Asp Glu Asp Leu His Gln Thr
65                  70                  75                  80  
Thr Leu Phe Gly Asn His Gly Thr Lys Thr Ser Val Pro Ser Val Asp
                85                  90                  95      
Ser Ile Lys Val His Gly Val Gly Arg Ala
            100                 105     


<210> 9
<211> 99
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpSEC12-s ER/Golgi Transmembrane Domain

<400> 9
atgcccagaa aaatatttaa ctacttcatt ttgactgtat tcatggcaat tcttgctatt 60
gttttacaat ggtctataga gaatggacat gggcgcgcc                        99

<210> 10
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpSEC12-s ER/Golgi Transmembrane Domain

<400> 10
Met Pro Arg Lys Ile Phe Asn Tyr Phe Ile Leu Thr Val Phe Met Ala
 1               5                  10                  15      
Ile Leu Ala Ile Val Leu Gln Trp Ser Ile Glu Asn Gly His Gly Arg
            20                  25                  30          
Ala
    


<210> 11
<211> 159
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpOCH1-s ER/Golgi Transmembrane Domain

<400> 11
atggcgaagg cagatggcag tttgctctac tataatcctc acaatccacc cagaaggtat 60
tacttctaca tggctatatt cgccgtttct gtcatttgcg ttttgtacgg accctcacaa 120
caattatcat ctccaaaaat agactatgat gggcgcgcc                        159

<210> 12
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpOCH1-s ER/Golgi Transmembrane Domain

<400> 12
Met Ala Lys Ala Asp Gly Ser Leu Leu Tyr Tyr Asn Pro His Asn Pro
 1               5                  10                  15      
Pro Arg Arg Tyr Tyr Phe Tyr Met Ala Ile Phe Ala Val Ser Val Ile
            20                  25                  30          
Cys Val Leu Tyr Gly Pro Ser Gln Gln Leu Ser Ser Pro Lys Ile Asp
        35                  40                  45              
Tyr Asp Gly Arg Ala
    50              


<210> 13
<211> 129
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN9-s ER/Golgi Transmembrane Domain

<400> 13
atgtcacttt ctcttgtatc gtaccgccta agaaagaacc cgtgggttaa catttttcta 60
cctgttttgg ccatatttct aatatatata atttttttcc agagagatca atctctgttg 120
gggcgcgcc                                                         129

<210> 14
<211> 43
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN9-s ER/Golgi Transmembrane Domain

<400> 14
Met Ser Leu Ser Leu Val Ser Tyr Arg Leu Arg Lys Asn Pro Trp Val
 1               5                  10                  15      
Asn Ile Phe Leu Pro Val Leu Ala Ile Phe Leu Ile Tyr Ile Ile Phe
            20                  25                  30          
Phe Gln Arg Asp Gln Ser Leu Leu Gly Arg Ala
        35                  40              


<210> 15
<211> 303
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScVAN1-m ER/Golgi Transmembrane Domain

<400> 15
atgggcatgt tttttaattt aaggtcaaat ataaagaaga aagccatgga caatggacta 60
agcctgccca tttcaaggaa cggtagctcg aacaacatca aggacaaacg ctcagagcat 120
aactccaact cattaaaggg caaatacagg taccagccgc gctccacacc gtctaaattc 180
cagcttacgg tgagtatcac atctcttatt attatcgccg ttctgtcgtt atatctcttt 240
atatcatttc tctccggaat gggcattggt gtatccacgc aaaatggtag gtcggggcgc 300
gcc                                                               303

<210> 16
<211> 101
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScVAN1-m ER/Golgi Transmembrane Domain

<400> 16
Met Gly Met Phe Phe Asn Leu Arg Ser Asn Ile Lys Lys Lys Ala Met
 1               5                  10                  15      
Asp Asn Gly Leu Ser Leu Pro Ile Ser Arg Asn Gly Ser Ser Asn Asn
            20                  25                  30          
Ile Lys Asp Lys Arg Ser Glu His Asn Ser Asn Ser Leu Lys Gly Lys
        35                  40                  45              
Tyr Arg Tyr Gln Pro Arg Ser Thr Pro Ser Lys Phe Gln Leu Thr Val
    50                  55                  60                  
Ser Ile Thr Ser Leu Ile Ile Ile Ala Val Leu Ser Leu Tyr Leu Phe
65                  70                  75                  80  
Ile Ser Phe Leu Ser Gly Met Gly Ile Gly Val Ser Thr Gln Asn Gly
                85                  90                  95      
Arg Ser Gly Arg Ala
            100     


<210> 17
<211> 189
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScANP1-s ER/Golgi Transmembrane Domain

<400> 17
atgaagtata ataacagaaa actctcgttc aaccctacca cagtaagtat cgctggaacg 60
ttgcttacgg tgttctttct cacaagactc gtgctttcgt tcttctcgat atcgctattc 120
cagctggtaa ctttccaagg aatcttcaag ccctatgttc cagattttaa aaatactccc 180
gggcgcgcc                                                         189

<210> 18
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScANP1-s ER/Golgi Transmembrane Domain

<400> 18
Met Lys Tyr Asn Asn Arg Lys Leu Ser Phe Asn Pro Thr Thr Val Ser
 1               5                  10                  15      
Ile Ala Gly Thr Leu Leu Thr Val Phe Phe Leu Thr Arg Leu Val Leu
            20                  25                  30          
Ser Phe Phe Ser Ile Ser Leu Phe Gln Leu Val Thr Phe Gln Gly Ile
        35                  40                  45              
Phe Lys Pro Tyr Val Pro Asp Phe Lys Asn Thr Pro Gly Arg Ala
    50                  55                  60              


<210> 19
<211> 111
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScHOC-s ER/Golgi Transmembrane Domain

<400> 19
atggccaaaa caacaaaaag agcctccagt ttcaggaggt tgatgatatt cgccataata 60
gccctcatct cattagcatt tggagttaga tacctatttc acgggcgcgc c          111

<210> 20
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScHOC-s ER/Golgi Transmembrane Domain

<400> 20
Met Ala Lys Thr Thr Lys Arg Ala Ser Ser Phe Arg Arg Leu Met Ile
 1               5                  10                  15      
Phe Ala Ile Ile Ala Leu Ile Ser Leu Ala Phe Gly Val Arg Tyr Leu
            20                  25                  30          
Phe His Gly Arg Ala
        35          


<210> 21
<211> 228
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN10-s ER/Golgi Transmembrane Domain

<400> 21
atgtctagtg taccttataa ttcccaactt cctatatcca accatctaga gtacgatgaa 60
gatgaaaaga agagcagagg ctcaaaacta ggcctgaaat ataaaatgat atactggagg 120
aaaactttat gcagttcgct agcgagatgg agaaagctaa tactattaat atctttagct 180
ttgtttttat tcatatggat aagcgattcc accataagcg ggcgcgcc              228

<210> 22
<211> 76
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN10-s ER/Golgi Transmembrane Domain

<400> 22
Met Ser Ser Val Pro Tyr Asn Ser Gln Leu Pro Ile Ser Asn His Leu
 1               5                  10                  15      
Glu Tyr Asp Glu Asp Glu Lys Lys Ser Arg Gly Ser Lys Leu Gly Leu
            20                  25                  30          
Lys Tyr Lys Met Ile Tyr Trp Arg Lys Thr Leu Cys Ser Ser Leu Ala
        35                  40                  45              
Arg Trp Arg Lys Leu Ile Leu Leu Ile Ser Leu Ala Leu Phe Leu Phe
    50                  55                  60                  
Ile Trp Ile Ser Asp Ser Thr Ile Ser Gly Arg Ala
65                  70                  75      


<210> 23
<211> 165
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN11-s ER/Golgi Transmembrane Domain

<400> 23
atggcaatca aaccaagaac gaagggcaaa acgtactcct caagatcggt gggttcgcag 60
tggttcaaca ggcttggttt caagcagaac aagtacggaa cttgtaaatt tttgtcgata 120
ataacggcct ttgtttttat cctctatttc ttctccgggc gcgcc                 165

<210> 24
<211> 55
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN11-s ER/Golgi Transmembrane Domain

<400> 24
Met Ala Ile Lys Pro Arg Thr Lys Gly Lys Thr Tyr Ser Ser Arg Ser
 1               5                  10                  15      
Val Gly Ser Gln Trp Phe Asn Arg Leu Gly Phe Lys Gln Asn Lys Tyr
            20                  25                  30          
Gly Thr Cys Lys Phe Leu Ser Ile Ile Thr Ala Phe Val Phe Ile Leu
        35                  40                  45              
Tyr Phe Phe Ser Gly Arg Ala
    50                  55  


<210> 25
<211> 183
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScKRE2-s ER/Golgi Transmembrane Domain

<400> 25
atggccctct ttctcagtaa gagactgttg agatttaccg tcattgcagg tgcggttatt 60
gttctcctcc taacattgaa ttccaacagt agaactcagc aatatattcc gagttccatc 120
tccgctgcat ttgattttac ctcaggatct atatcccctg aacaacaagt catcgggcgc 180
gcc                                                               183

<210> 26
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScKRE2-s ER/Golgi Transmembrane Domain

<400> 26
Met Ala Leu Phe Leu Ser Lys Arg Leu Leu Arg Phe Thr Val Ile Ala
 1               5                  10                  15      
Gly Ala Val Ile Val Leu Leu Leu Thr Leu Asn Ser Asn Ser Arg Thr
            20                  25                  30          
Gln Gln Tyr Ile Pro Ser Ser Ile Ser Ala Ala Phe Asp Phe Thr Ser
        35                  40                  45              
Gly Ser Ile Ser Pro Glu Gln Gln Val Ile Gly Arg Ala
    50                  55                  60      


<210> 27
<211> 315
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScKRE2-l ER/Golgi Transmembrane Domain

<400> 27
atggccctct ttctcagtaa gagactgttg agatttaccg tcattgcagg tgcggttatt 60
gttctcctcc taacattgaa ttccaacagt agaactcagc aatatattcc gagttccatc 120
tccgctgcat ttgattttac ctcaggatct atatcccctg aacaacaagt catctctgag 180
gaaaatgatg ctaaaaaatt agagcaaagt gctctgaatt cagaggcaag cgaagactcc 240
gaagccatgg atgaagaatc caaggctctg aaagctgccg ctgaaaaggc agatgccccg 300
atcgacgggc gcgcc                                                  315

<210> 28
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScKRE2-l ER/Golgi Transmembrane Domain

<400> 28
Met Ala Leu Phe Leu Ser Lys Arg Leu Leu Arg Phe Thr Val Ile Ala
 1               5                  10                  15      
Gly Ala Val Ile Val Leu Leu Leu Thr Leu Asn Ser Asn Ser Arg Thr
            20                  25                  30          
Gln Gln Tyr Ile Pro Ser Ser Ile Ser Ala Ala Phe Asp Phe Thr Ser
        35                  40                  45              
Gly Ser Ile Ser Pro Glu Gln Gln Val Ile Ser Glu Glu Asn Asp Ala
    50                  55                  60                  
Lys Lys Leu Glu Gln Ser Ala Leu Asn Ser Glu Ala Ser Glu Asp Ser
65                  70                  75                  80  
Glu Ala Met Asp Glu Glu Ser Lys Ala Leu Lys Ala Ala Ala Glu Lys
                85                  90                  95      
Ala Asp Ala Pro Ile Asp Gly Arg Ala
            100                 105 


<210> 29
<211> 225
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpKTR1-s ER/Golgi Transmembrane Domain

<400> 29
atggaattag tgcgcctggc caatcttgtc aacgtcaacc accctttcga gcaaagcaat 60
atatatcgcg ttccactttt cttccttctc tcaactacca gaccagacag gacaacggta 120
caaatggcag gtgcaactag gatcaattca cgagtagttc ggtttgctat tttcgcatca 180
atcctggtac tgttaggatt catcctatca agaggggggc gcgcc                 225

<210> 30
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpKTR1-s ER/Golgi Transmembrane Domain

<400> 30
Met Glu Leu Val Arg Leu Ala Asn Leu Val Asn Val Asn His Pro Phe
 1               5                  10                  15      
Glu Gln Ser Asn Ile Tyr Arg Val Pro Leu Phe Phe Leu Leu Ser Thr
            20                  25                  30          
Thr Arg Pro Asp Arg Thr Thr Val Gln Met Ala Gly Ala Thr Arg Ile
        35                  40                  45              
Asn Ser Arg Val Val Arg Phe Ala Ile Phe Ala Ser Ile Leu Val Leu
    50                  55                  60                  
Leu Gly Phe Ile Leu Ser Arg Gly Gly Arg Ala
65                  70                  75  


<210> 31
<211> 102
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpKTR3-s ER/Golgi Transmembrane Domain

<400> 31
atgatgcgag caagattaag ccttgaacga gttaacttga gctttattac gtccgtattt 60
ttggcttcag ttgcagttct tttcatctct ttggggcgcg cc                    102

<210> 32
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpKTR3-s ER/Golgi Transmembrane Domain

<400> 32
Met Met Arg Ala Arg Leu Ser Leu Glu Arg Val Asn Leu Ser Phe Ile
 1               5                  10                  15      
Thr Ser Val Phe Leu Ala Ser Val Ala Val Leu Phe Ile Ser Leu Gly
            20                  25                  30          
Arg Ala
        


<210> 33
<211> 102
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpKRE2-s ER/Golgi Transmembrane Domain

<400> 33
atggtacaca tagggttcag aagcttgaaa gcggtgttca ttttggccct ttcgtcattg 60
attctgtacg ggattgtcac gacctttgac ggggggcgcg cc                    102

<210> 34
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpKRE2-s ER/Golgi Transmembrane Domain

<400> 34
Met Val His Ile Gly Phe Arg Ser Leu Lys Ala Val Phe Ile Leu Ala
 1               5                  10                  15      
Leu Ser Ser Leu Ile Leu Tyr Gly Ile Val Thr Thr Phe Asp Gly Gly
            20                  25                  30          
Arg Ala
        


<210> 35
<211> 126
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScKTR1-s ER/Golgi Transmembrane Domain

<400> 35
atggcgaaga ttatgatccc agctagcaag cagcctgttt acaaaaaatt aggacttctt 60
ctggtcgccg tgtttactgt gtatgtgttc tttcatggag ctcagtatgc gagaggcggg 120
cgcgcc                                                            126

<210> 36
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScKTR1-s ER/Golgi Transmembrane Domain

<400> 36
Met Ala Lys Ile Met Ile Pro Ala Ser Lys Gln Pro Val Tyr Lys Lys
 1               5                  10                  15      
Leu Gly Leu Leu Leu Val Ala Val Phe Thr Val Tyr Val Phe Phe His
            20                  25                  30          
Gly Ala Gln Tyr Ala Arg Gly Gly Arg Ala
        35                  40          


<210> 37
<211> 129
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScKTR2-s ER/Golgi Transmembrane Domain

<400> 37
atgcaaatct gcaaggtatt tcttacacag gttaaaaaac tactttttgt tagtcttcta 60
ttttgcttga tagctcaaac atgttggctt gcacttgtac catatcagag acagctgagc 120
gggcgcgcc                                                         129

<210> 38
<211> 43
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScKTR2-s ER/Golgi Transmembrane Domain

<400> 38
Met Gln Ile Cys Lys Val Phe Leu Thr Gln Val Lys Lys Leu Leu Phe
 1               5                  10                  15      
Val Ser Leu Leu Phe Cys Leu Ile Ala Gln Thr Cys Trp Leu Ala Leu
            20                  25                  30          
Val Pro Tyr Gln Arg Gln Leu Ser Gly Arg Ala
        35                  40              


<210> 39
<211> 102
<212> DNA
<213> Artificial Sequence

<220> 
<223> KlGNT1-s ER/Golgi Transmembrane Domain

<400> 39
atggcttttg gatctagaag gaaaatcaag gccattttgg tcgctgcttc tgctatggtc 60
tttatttctc tacttggaac gtttggatcc gacgggcgcg cc                    102

<210> 40
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> KlGNT1-s ER/Golgi Transmembrane Domain

<400> 40
Met Ala Phe Gly Ser Arg Arg Lys Ile Lys Ala Ile Leu Val Ala Ala
 1               5                  10                  15      
Ser Ala Met Val Phe Ile Ser Leu Leu Gly Thr Phe Gly Ser Asp Gly
            20                  25                  30          
Arg Ala
        


<210> 41
<211> 117
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN2-s ER/Golgi Transmembrane Domain

<400> 41
atgctgctta ccaaaaggtt ttcaaagctg ttcaagctga cgttcatagt tttgatattg 60
tgcgggctgt tcgtcattac aaacaaatac atggatgaga acacgtcggg gcgcgcc    117

<210> 42
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN2-s ER/Golgi Transmembrane Domain

<400> 42
Met Leu Leu Thr Lys Arg Phe Ser Lys Leu Phe Lys Leu Thr Phe Ile
 1               5                  10                  15      
Val Leu Ile Leu Cys Gly Leu Phe Val Ile Thr Asn Lys Tyr Met Asp
            20                  25                  30          
Glu Asn Thr Ser Gly Arg Ala
        35                  


<210> 43
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN2-m ER/Golgi Transmembrane Domain

<400> 43
atgctgctta ccaaaaggtt ttcaaagctg ttcaagctga cgttcatagt tttgatattg 60
tgcgggctgt tcgtcattac aaacaaatac atggatgaga acacgtcggt caaggagtac 120
aaggagtact tagacagata tgtccagagt tactccaata agtattcatc ttcctcagac 180
gccgccagcg ctgacgattc aaccccattg agggacaatg atgaggcagg caatgaaaag 240
ttgaaaagct tctacaacaa cgttttcaac tttctaatgg ttgattcgcc cgggcgcgcc 300


<210> 44
<211> 100
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN2-m ER/Golgi Transmembrane Domain

<400> 44
Met Leu Leu Thr Lys Arg Phe Ser Lys Leu Phe Lys Leu Thr Phe Ile
 1               5                  10                  15      
Val Leu Ile Leu Cys Gly Leu Phe Val Ile Thr Asn Lys Tyr Met Asp
            20                  25                  30          
Glu Asn Thr Ser Val Lys Glu Tyr Lys Glu Tyr Leu Asp Arg Tyr Val
        35                  40                  45              
Gln Ser Tyr Ser Asn Lys Tyr Ser Ser Ser Ser Asp Ala Ala Ser Ala
    50                  55                  60                  
Asp Asp Ser Thr Pro Leu Arg Asp Asn Asp Glu Ala Gly Asn Glu Lys
65                  70                  75                  80  
Leu Lys Ser Phe Tyr Asn Asn Val Phe Asn Phe Leu Met Val Asp Ser
                85                  90                  95      
Pro Gly Arg Ala
            100 


<210> 45
<211> 114
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN5-s ER/Golgi Transmembrane Domain

<400> 45
atgctgatta ggttaaagaa gagaaaaatc ctgcaggtca tcgtgagcgc agtagtgcta 60
attttatttt tttgttctgt gcataatgat gtgtcttcta gttgggggcg cgcc       114

<210> 46
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN5-s ER/Golgi Transmembrane Domain

<400> 46
Met Leu Ile Arg Leu Lys Lys Arg Lys Ile Leu Gln Val Ile Val Ser
 1               5                  10                  15      
Ala Val Val Leu Ile Leu Phe Phe Cys Ser Val His Asn Asp Val Ser
            20                  25                  30          
Ser Ser Trp Gly Arg Ala
        35              


<210> 47
<211> 117
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScYUR1-s ER/Golgi Transmembrane Domain

<400> 47
atggcaaaag gaggctcgct atacatcgtt ggcatattct taccaatatg gacctttatg 60
atctatattt ttggcaaaga gttattcctc atacgaaaat accaaaaggg gcgcgcc    117

<210> 48
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScYUR1-s ER/Golgi Transmembrane Domain

<400> 48
Met Ala Lys Gly Gly Ser Leu Tyr Ile Val Gly Ile Phe Leu Pro Ile
 1               5                  10                  15      
Trp Thr Phe Met Ile Tyr Ile Phe Gly Lys Glu Leu Phe Leu Ile Arg
            20                  25                  30          
Lys Tyr Gln Lys Gly Arg Ala
        35                  


<210> 49
<211> 135
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN1-s ER/Golgi Transmembrane Domain

<400> 49
atgttggcac tccggagatt tatattaaac caaaggtctt tgagatcgtg taccataccg 60
attctagtcg gagccttgat cattattctc gtgctattcc aactagttac ccaccgaaat 120
gatgcggggc gcgcc                                                  135

<210> 50
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN1-s ER/Golgi Transmembrane Domain

<400> 50
Met Leu Ala Leu Arg Arg Phe Ile Leu Asn Gln Arg Ser Leu Arg Ser
 1               5                  10                  15      
Cys Thr Ile Pro Ile Leu Val Gly Ala Leu Ile Ile Ile Leu Val Leu
            20                  25                  30          
Phe Gln Leu Val Thr His Arg Asn Asp Ala Gly Arg Ala
        35                  40                  45  


<210> 51
<211> 99
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScMNN6-s ER/Golgi Transmembrane Domain

<400> 51
atgcacgtac tgctgagcaa aaaaatagca cgctttctgt tgatttcgtt tgttttcgtg 60
cttgcgctaa tggtgacaat aaatcatcca gggcgcgcc                        99

<210> 52
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScMNN6-s ER/Golgi Transmembrane Domain

<400> 52
Met His Val Leu Leu Ser Lys Lys Ile Ala Arg Phe Leu Leu Ile Ser
 1               5                  10                  15      
Phe Val Phe Val Leu Ala Leu Met Val Thr Ile Asn His Pro Gly Arg
            20                  25                  30          


<210> 53
<211> 222
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT1-s ER/Golgi Transmembrane Domain

<400> 53
atgtcggaag agaaaacgta caaacgtgta gagcaggatg atcccgtgcc cgaactggat 60
atcaagcagg gccccgtaag accctttatt gttaccgatc cgagtgccga attggcctcg 120
ttacgaacca tggtcactct taaagagaag ctgttagtgg cctgtcttgc tgtctttaca 180
gcggtcatta gattgcatgg cttggcatgg cctgggcgcg cc                    222

<210> 54
<211> 74
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT1-s ER/Golgi Transmembrane Domain

<400> 54
Met Ser Glu Glu Lys Thr Tyr Lys Arg Val Glu Gln Asp Asp Pro Val
 1               5                  10                  15      
Pro Glu Leu Asp Ile Lys Gln Gly Pro Val Arg Pro Phe Ile Val Thr
            20                  25                  30          
Asp Pro Ser Ala Glu Leu Ala Ser Leu Arg Thr Met Val Thr Leu Lys
        35                  40                  45              
Glu Lys Leu Leu Val Ala Cys Leu Ala Val Phe Thr Ala Val Ile Arg
    50                  55                  60                  
Leu His Gly Leu Ala Trp Pro Gly Arg Ala
65                  70                  


<210> 55
<211> 246
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT2-s ER/Golgi Transmembrane Domain

<400> 55
atgtcctcgt cttcgtctac cgggtacagc aaaaacaatg ccgcccacat taagcaagag 60
aatacactga gacaaagaga atcgtcttcc atcagcgtca gtgaggaact ttcgagcgct 120
gatgagagag acgcggaaga tttctcgaag gaaaagcccg ctgcacaaag ctcactgtta 180
cgcctggaat ccgttgtaat gccggtgatc tttactgcat tggcgttgtt taccaggggg 240
cgcgcc                                                            246

<210> 56
<211> 82
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT2-s ER/Golgi Transmembrane Domain

<400> 56
Met Ser Ser Ser Ser Ser Thr Gly Tyr Ser Lys Asn Asn Ala Ala His
 1               5                  10                  15      
Ile Lys Gln Glu Asn Thr Leu Arg Gln Arg Glu Ser Ser Ser Ile Ser
            20                  25                  30          
Val Ser Glu Glu Leu Ser Ser Ala Asp Glu Arg Asp Ala Glu Asp Phe
        35                  40                  45              
Ser Lys Glu Lys Pro Ala Ala Gln Ser Ser Leu Leu Arg Leu Glu Ser
    50                  55                  60                  
Val Val Met Pro Val Ile Phe Thr Ala Leu Ala Leu Phe Thr Arg Gly
65                  70                  75                  80  
Arg Ala
        


<210> 57
<211> 222
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT3-s ER/Golgi Transmembrane Domain

<400> 57
atgccgtaca gagtggcgac gggctacagt gaaaaaagta ctgacgatga tttgatatgg 60
agaacgccaa tagtaaaaga ggaactcgag gatgctgaca actttttaaa ggatgatgcc 120
gagttgtatg ataaagtcaa gaacgagagt gcagtatcac acctggatac catagttatg 180
ccgatcattt tcacggtact gggcatgttc actgggcgcg cc                    222

<210> 58
<211> 74
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT3-s ER/Golgi Transmembrane Domain

<400> 58
Met Pro Tyr Arg Val Ala Thr Gly Tyr Ser Glu Lys Ser Thr Asp Asp
 1               5                  10                  15      
Asp Leu Ile Trp Arg Thr Pro Ile Val Lys Glu Glu Leu Glu Asp Ala
            20                  25                  30          
Asp Asn Phe Leu Lys Asp Asp Ala Glu Leu Tyr Asp Lys Val Lys Asn
        35                  40                  45              
Glu Ser Ala Val Ser His Leu Asp Thr Ile Val Met Pro Ile Ile Phe
    50                  55                  60                  
Thr Val Leu Gly Met Phe Thr Gly Arg Ala
65                  70                  


<210> 59
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT4-s ER/Golgi Transmembrane Domain

<400> 59
atgtctgtgc ccaaaaaacg taaccatggg aagttaccac cttccactaa ggacgtagac 60
gatccttcgt tgaagtacac gaaggccgcg cctaaatgtg aacaagttgc tgaacattgg 120
ctcttgcagc cactaccgga accggaatca cgttatagct tttgggtaac aattgttacc 180
ttattagcgt ttgctgctag attttataag atctggtatc caaaagaagt tgtttttgat 240
gaggtacatt tcgggaaatt tgcatcgtat tacttagaaa ggtcttattt ctttgacgtt 300
catccccctt ttgctaagat gatgattgcc ttcattggtt ggttatgtgg ctatgatggg 360
cgcgcc                                                            366

<210> 60
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT4-s ER/Golgi Transmembrane Domain

<400> 60
Met Ser Val Pro Lys Lys Arg Asn His Gly Lys Leu Pro Pro Ser Thr
 1               5                  10                  15      
Lys Asp Val Asp Asp Pro Ser Leu Lys Tyr Thr Lys Ala Ala Pro Lys
            20                  25                  30          
Cys Glu Gln Val Ala Glu His Trp Leu Leu Gln Pro Leu Pro Glu Pro
        35                  40                  45              
Glu Ser Arg Tyr Ser Phe Trp Val Thr Ile Val Thr Leu Leu Ala Phe
    50                  55                  60                  
Ala Ala Arg Phe Tyr Lys Ile Trp Tyr Pro Lys Glu Val Val Phe Asp
65                  70                  75                  80  
Glu Val His Phe Gly Lys Phe Ala Ser Tyr Tyr Leu Glu Arg Ser Tyr
                85                  90                  95      
Phe Phe Asp Val His Pro Pro Phe Ala Lys Met Met Ile Ala Phe Ile
            100                 105                 110         
Gly Trp Leu Cys Gly Tyr Asp Gly Arg Ala
        115                 120         


<210> 61
<211> 204
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT5-s ER/Golgi Transmembrane Domain

<400> 61
atgaataaag agcatttgct gaaggtggat cccatccccg atgtgactat taaacgcggc 60
cctttgaggt cttttctcat aacaaaaccc tgtgataatt tgagttcatt acgaacagtt 120
acttcatcta aggaaaagct tctagttggc tgtttgctga tatttactgc catcgtaagg 180
ctacacaata tctccgggcg cgcc                                        204

<210> 62
<211> 68
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT5-s ER/Golgi Transmembrane Domain

<400> 62
Met Asn Lys Glu His Leu Leu Lys Val Asp Pro Ile Pro Asp Val Thr
 1               5                  10                  15      
Ile Lys Arg Gly Pro Leu Arg Ser Phe Leu Ile Thr Lys Pro Cys Asp
            20                  25                  30          
Asn Leu Ser Ser Leu Arg Thr Val Thr Ser Ser Lys Glu Lys Leu Leu
        35                  40                  45              
Val Gly Cys Leu Leu Ile Phe Thr Ala Ile Val Arg Leu His Asn Ile
    50                  55                  60                  
Ser Gly Arg Ala
65              


<210> 63
<211> 552
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT6-s ER/Golgi Transmembrane Domain

<400> 63
atgagtaaag ccaagggaac gggattttca tcaattgata ctgaagatga aaacttacgc 60
gaacgttatg ttaatcaacc aaaagctaat gcctccgata ttcaagatga acaattagat 120
tgctttgagc aactagaaga aaaacatagg acaaaaaaaa atgaagaata cactgcgttg 180
aaaattttaa gggatgtcat aggtcccctt ttattaacta taacttcgtt ttatctaaga 240
ttccaacata tagatcagaa caattatgtt gtctgggatg aggctcattt tgggaaattc 300
ggatcatact acatcaaaca tgagtactac cacgatgtcc accctccact tggtaaaatg 360
cttattgcat tgagcgaatg gatggcagga tttgacggtc aatttgactt ttcctctaat 420
aatgcatatc cggaaaacgt aaactttaaa ctaatgagac aatttaatgc cacatttgga 480
gctctatgta caccagtagc tttctttaca gccaaatgga tggggttcaa ttattttact 540
gttgggcgcg cc                                                     552

<210> 64
<211> 184
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT6-s ER/Golgi Transmembrane Domain

<400> 64
Met Ser Lys Ala Lys Gly Thr Gly Phe Ser Ser Ile Asp Thr Glu Asp
 1               5                  10                  15      
Glu Asn Leu Arg Glu Arg Tyr Val Asn Gln Pro Lys Ala Asn Ala Ser
            20                  25                  30          
Asp Ile Gln Asp Glu Gln Leu Asp Cys Phe Glu Gln Leu Glu Glu Lys
        35                  40                  45              
His Arg Thr Lys Lys Asn Glu Glu Tyr Thr Ala Leu Lys Ile Leu Arg
    50                  55                  60                  
Asp Val Ile Gly Pro Leu Leu Leu Thr Ile Thr Ser Phe Tyr Leu Arg
65                  70                  75                  80  
Phe Gln His Ile Asp Gln Asn Asn Tyr Val Val Trp Asp Glu Ala His
                85                  90                  95      
Phe Gly Lys Phe Gly Ser Tyr Tyr Ile Lys His Glu Tyr Tyr His Asp
            100                 105                 110         
Val His Pro Pro Leu Gly Lys Met Leu Ile Ala Leu Ser Glu Trp Met
        115                 120                 125             
Ala Gly Phe Asp Gly Gln Phe Asp Phe Ser Ser Asn Asn Ala Tyr Pro
    130                 135                 140                 
Glu Asn Val Asn Phe Lys Leu Met Arg Gln Phe Asn Ala Thr Phe Gly
145                 150                 155                 160 
Ala Leu Cys Thr Pro Val Ala Phe Phe Thr Ala Lys Trp Met Gly Phe
                165                 170                 175     
Asn Tyr Phe Thr Val Gly Arg Ala
            180                 


<210> 65
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT1-m ER/Golgi Transmembrane Domain

<400> 65
atgtcggaag agaaaacgta caaacgtgta gagcaggatg atcccgtgcc cgaactggat 60
atcaagcagg gccccgtaag accctttatt gttaccgatc cgagtgccga attggcctcg 120
ttacgaacca tggtcactct taaagagaag ctgttagtgg cctgtcttgc tgtctttaca 180
gcggtcatta gattgcatgg cttggcatgg cctgacagcg tggtgtttga tgaagtacat 240
ttcggtgggt ttgcctcgca atacattagg gggacttact tcatggatgt gcatcctcct 300
cttgcaaaga tgttgtatgc tggtgtggca gggcgcgcc                        339

<210> 66
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT1-m ER/Golgi Transmembrane Domain

<400> 66
Met Ser Glu Glu Lys Thr Tyr Lys Arg Val Glu Gln Asp Asp Pro Val
 1               5                  10                  15      
Pro Glu Leu Asp Ile Lys Gln Gly Pro Val Arg Pro Phe Ile Val Thr
            20                  25                  30          
Asp Pro Ser Ala Glu Leu Ala Ser Leu Arg Thr Met Val Thr Leu Lys
        35                  40                  45              
Glu Lys Leu Leu Val Ala Cys Leu Ala Val Phe Thr Ala Val Ile Arg
    50                  55                  60                  
Leu His Gly Leu Ala Trp Pro Asp Ser Val Val Phe Asp Glu Val His
65                  70                  75                  80  
Phe Gly Gly Phe Ala Ser Gln Tyr Ile Arg Gly Thr Tyr Phe Met Asp
                85                  90                  95      
Val His Pro Pro Leu Ala Lys Met Leu Tyr Ala Gly Val Ala Gly Arg
            100                 105                 110         
Ala
    


<210> 67
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT2-m ER/Golgi Transmembrane Domain

<400> 67
atgtcctcgt cttcgtctac cgggtacagc aaaaacaatg ccgcccacat taagcaagag 60
aatacactga gacaaagaga atcgtcttcc atcagcgtca gtgaggaact ttcgagcgct 120
gatgagagag acgcggaaga tttctcgaag gaaaagcccg ctgcacaaag ctcactgtta 180
cgcctggaat ccgttgtaat gccggtgatc tttactgcat tggcgttgtt taccaggatg 240
tacaaaatcg gcatcaacaa ccatgttgtt tgggatgagg cgcactttgg taaatttggt 300
tcttattact tgagacacga attttaccac gatgtccatc ctcccctagg aaaaatgctg 360
gggcgcgcc                                                         369

<210> 68
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT2-m ER/Golgi Transmembrane Domain

<400> 68
Met Ser Ser Ser Ser Ser Thr Gly Tyr Ser Lys Asn Asn Ala Ala His
 1               5                  10                  15      
Ile Lys Gln Glu Asn Thr Leu Arg Gln Arg Glu Ser Ser Ser Ile Ser
            20                  25                  30          
Val Ser Glu Glu Leu Ser Ser Ala Asp Glu Arg Asp Ala Glu Asp Phe
        35                  40                  45              
Ser Lys Glu Lys Pro Ala Ala Gln Ser Ser Leu Leu Arg Leu Glu Ser
    50                  55                  60                  
Val Val Met Pro Val Ile Phe Thr Ala Leu Ala Leu Phe Thr Arg Met
65                  70                  75                  80  
Tyr Lys Ile Gly Ile Asn Asn His Val Val Trp Asp Glu Ala His Phe
                85                  90                  95      
Gly Lys Phe Gly Ser Tyr Tyr Leu Arg His Glu Phe Tyr His Asp Val
            100                 105                 110         
His Pro Pro Leu Gly Lys Met Leu Gly Arg Ala
        115                 120             


<210> 69
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT3-m ER/Golgi Transmembrane Domain

<400> 69
atgccgtaca gagtggcgac gggctacagt gaaaaaagta ctgacgatga tttgatatgg 60
agaacgccaa tagtaaaaga ggaactcgag gatgctgaca actttttaaa ggatgatgcc 120
gagttgtatg ataaagtcaa gaacgagagt gcagtatcac acctggatac catagttatg 180
ccgatcattt tcacggtact gggcatgttc actagaatgt acaagattgg tcgtaataat 240
catgtggtct gggatgaagc tcattttggt aagttcggct cttactatct gagacacgaa 300
ttttaccatg atgttcatcc acctttaggt gggcgcgcc                        339

<210> 70
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT3-m ER/Golgi Transmembrane Domain

<400> 70
Met Pro Tyr Arg Val Ala Thr Gly Tyr Ser Glu Lys Ser Thr Asp Asp
 1               5                  10                  15      
Asp Leu Ile Trp Arg Thr Pro Ile Val Lys Glu Glu Leu Glu Asp Ala
            20                  25                  30          
Asp Asn Phe Leu Lys Asp Asp Ala Glu Leu Tyr Asp Lys Val Lys Asn
        35                  40                  45              
Glu Ser Ala Val Ser His Leu Asp Thr Ile Val Met Pro Ile Ile Phe
    50                  55                  60                  
Thr Val Leu Gly Met Phe Thr Arg Met Tyr Lys Ile Gly Arg Asn Asn
65                  70                  75                  80  
His Val Val Trp Asp Glu Ala His Phe Gly Lys Phe Gly Ser Tyr Tyr
                85                  90                  95      
Leu Arg His Glu Phe Tyr His Asp Val His Pro Pro Leu Gly Gly Arg
            100                 105                 110         
Ala
    


<210> 71
<211> 414
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT4-m ER/Golgi Transmembrane Domain

<400> 71
atgtctgtgc ccaaaaaacg taaccatggg aagttaccac cttccactaa ggacgtagac 60
gatccttcgt tgaagtacac gaaggccgcg cctaaatgtg aacaagttgc tgaacattgg 120
ctcttgcagc cactaccgga accggaatca cgttatagct tttgggtaac aattgttacc 180
ttattagcgt ttgctgctag attttataag atctggtatc caaaagaagt tgtttttgat 240
gaggtacatt tcgggaaatt tgcatcgtat tacttagaaa ggtcttattt ctttgacgtt 300
catccccctt ttgctaagat gatgattgcc ttcattggtt ggttatgtgg ctatgatggt 360
tcctttaagt ttgatgagat tgggtattct tatgaaactc atccagggcg cgcc       414

<210> 72
<211> 138
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT4-m ER/Golgi Transmembrane Domain

<400> 72
Met Ser Val Pro Lys Lys Arg Asn His Gly Lys Leu Pro Pro Ser Thr
 1               5                  10                  15      
Lys Asp Val Asp Asp Pro Ser Leu Lys Tyr Thr Lys Ala Ala Pro Lys
            20                  25                  30          
Cys Glu Gln Val Ala Glu His Trp Leu Leu Gln Pro Leu Pro Glu Pro
        35                  40                  45              
Glu Ser Arg Tyr Ser Phe Trp Val Thr Ile Val Thr Leu Leu Ala Phe
    50                  55                  60                  
Ala Ala Arg Phe Tyr Lys Ile Trp Tyr Pro Lys Glu Val Val Phe Asp
65                  70                  75                  80  
Glu Val His Phe Gly Lys Phe Ala Ser Tyr Tyr Leu Glu Arg Ser Tyr
                85                  90                  95      
Phe Phe Asp Val His Pro Pro Phe Ala Lys Met Met Ile Ala Phe Ile
            100                 105                 110         
Gly Trp Leu Cys Gly Tyr Asp Gly Ser Phe Lys Phe Asp Glu Ile Gly
        115                 120                 125             
Tyr Ser Tyr Glu Thr His Pro Gly Arg Ala
    130                 135             


<210> 73
<211> 264
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT5-m ER/Golgi Transmembrane Domain

<400> 73
atgaataaag agcatttgct gaaggtggat cccatccccg atgtgactat taaacgcggc 60
cctttgaggt cttttctcat aacaaaaccc tgtgataatt tgagttcatt acgaacagtt 120
acttcatcta aggaaaagct tctagttggc tgtttgctga tatttactgc catcgtaagg 180
ctacacaata tctccctgcc aaatagtgtt gtttttggtg aaaatgaagt tggtacattt 240
gtttctcaat acgtggggcg cgcc                                        264

<210> 74
<211> 88
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT5-m ER/Golgi Transmembrane Domain

<400> 74
Met Asn Lys Glu His Leu Leu Lys Val Asp Pro Ile Pro Asp Val Thr
 1               5                  10                  15      
Ile Lys Arg Gly Pro Leu Arg Ser Phe Leu Ile Thr Lys Pro Cys Asp
            20                  25                  30          
Asn Leu Ser Ser Leu Arg Thr Val Thr Ser Ser Lys Glu Lys Leu Leu
        35                  40                  45              
Val Gly Cys Leu Leu Ile Phe Thr Ala Ile Val Arg Leu His Asn Ile
    50                  55                  60                  
Ser Leu Pro Asn Ser Val Val Phe Gly Glu Asn Glu Val Gly Thr Phe
65                  70                  75                  80  
Val Ser Gln Tyr Val Gly Arg Ala
                85              


<210> 75
<211> 594
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScPMT6-m ER/Golgi Transmembrane Domain

<400> 75
atgagtaaag ccaagggaac gggattttca tcaattgata ctgaagatga aaacttacgc 60
gaacgttatg ttaatcaacc aaaagctaat gcctccgata ttcaagatga acaattagat 120
tgctttgagc aactagaaga aaaacatagg acaaaaaaaa atgaagaata cactgcgttg 180
aaaattttaa gggatgtcat aggtcccctt ttattaacta taacttcgtt ttatctaaga 240
ttccaacata tagatcagaa caattatgtt gtctgggatg aggctcattt tgggaaattc 300
ggatcatact acatcaaaca tgagtactac cacgatgtcc accctccact tggtaaaatg 360
cttattgcat tgagcgaatg gatggcagga tttgacggtc aatttgactt ttcctctaat 420
aatgcatatc cggaaaacgt aaactttaaa ctaatgagac aatttaatgc cacatttgga 480
gctctatgta caccagtagc tttctttaca gccaaatgga tggggttcaa ttattttact 540
gtttatttga ttgctacgat ggtaacgttg gaacattcat atattgggcg cgcc       594

<210> 76
<211> 198
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScPMT6-m ER/Golgi Transmembrane Domain

<400> 76
Met Ser Lys Ala Lys Gly Thr Gly Phe Ser Ser Ile Asp Thr Glu Asp
 1               5                  10                  15      
Glu Asn Leu Arg Glu Arg Tyr Val Asn Gln Pro Lys Ala Asn Ala Ser
            20                  25                  30          
Asp Ile Gln Asp Glu Gln Leu Asp Cys Phe Glu Gln Leu Glu Glu Lys
        35                  40                  45              
His Arg Thr Lys Lys Asn Glu Glu Tyr Thr Ala Leu Lys Ile Leu Arg
    50                  55                  60                  
Asp Val Ile Gly Pro Leu Leu Leu Thr Ile Thr Ser Phe Tyr Leu Arg
65                  70                  75                  80  
Phe Gln His Ile Asp Gln Asn Asn Tyr Val Val Trp Asp Glu Ala His
                85                  90                  95      
Phe Gly Lys Phe Gly Ser Tyr Tyr Ile Lys His Glu Tyr Tyr His Asp
            100                 105                 110         
Val His Pro Pro Leu Gly Lys Met Leu Ile Ala Leu Ser Glu Trp Met
        115                 120                 125             
Ala Gly Phe Asp Gly Gln Phe Asp Phe Ser Ser Asn Asn Ala Tyr Pro
    130                 135                 140                 
Glu Asn Val Asn Phe Lys Leu Met Arg Gln Phe Asn Ala Thr Phe Gly
145                 150                 155                 160 
Ala Leu Cys Thr Pro Val Ala Phe Phe Thr Ala Lys Trp Met Gly Phe
                165                 170                 175     
Asn Tyr Phe Thr Val Tyr Leu Ile Ala Thr Met Val Thr Leu Glu His
            180                 185                 190         
Ser Tyr Ile Gly Arg Ala
        195             


<210> 77
<211> 264
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT1-s ER/Golgi Transmembrane Domain

<400> 77
atgtgccaga tatttctccc gcaaaacgta acacgttgtt ctgtttccct tttgacaatg 60
agtaaaacaa gtcctcaaga ggtgccagaa aacactactg agcttaaaat ctcaaaagga 120
gagctccgtc cttttattgt gacctctcca tctcctcaat tgagcaagtc tcgttctgtg 180
acttcaacca aggagaagct gatattggct agtttgttca tatttgcaat ggtcatcagg 240
ttccacaacg tcgccgggcg cgcc                                        264

<210> 78
<211> 88
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT1-s ER/Golgi Transmembrane Domain

<400> 78
Met Cys Gln Ile Phe Leu Pro Gln Asn Val Thr Arg Cys Ser Val Ser
 1               5                  10                  15      
Leu Leu Thr Met Ser Lys Thr Ser Pro Gln Glu Val Pro Glu Asn Thr
            20                  25                  30          
Thr Glu Leu Lys Ile Ser Lys Gly Glu Leu Arg Pro Phe Ile Val Thr
        35                  40                  45              
Ser Pro Ser Pro Gln Leu Ser Lys Ser Arg Ser Val Thr Ser Thr Lys
    50                  55                  60                  
Glu Lys Leu Ile Leu Ala Ser Leu Phe Ile Phe Ala Met Val Ile Arg
65                  70                  75                  80  
Phe His Asn Val Ala Gly Arg Ala
                85              


<210> 79
<211> 603
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT2-s ER/Golgi Transmembrane Domain

<400> 79
atgacaggcc gtgtcgacca gaaatctgat cagaaggtga aggaattgat cgaaaagatc 60
gactccgaat ccacttccag agtttttcag gaagaaccag tcacttcgat cttgacacgt 120
tacgaaccct atgtcgcccc aattatattc acgttgttgt cctttttcac tcgtatgtac 180
aaaattggga tcaacaacca cgtcgtttgg gatgaagctc acttcggaaa gtttggctcc 240
tactatctca gacacgagtt ctaccacgat gtccaccctc cgttgggtaa gatgttggtc 300
ggtctatctg gctacattgc cggttacaat ggctcctggg atttcccctc cggtcaagag 360
taccctgact atattgatta cgttaaaatg aggttattca atgccacctt cagtgcctta 420
tgtgtgccat tcgcctattt caccatgaag gagattggat ttgatatcaa gacaacttgg 480
ctattcacac tgatggtctt gtgtgaaaca agttattgta cgttaggaaa attcatcttg 540
ctggattcaa tgctgctgct attcactgtg actacggttt tcacctttgt tagggggcgc 600
gcc                                                               603

<210> 80
<211> 201
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT2-s ER/Golgi Transmembrane Domain

<400> 80
Met Thr Gly Arg Val Asp Gln Lys Ser Asp Gln Lys Val Lys Glu Leu
 1               5                  10                  15      
Ile Glu Lys Ile Asp Ser Glu Ser Thr Ser Arg Val Phe Gln Glu Glu
            20                  25                  30          
Pro Val Thr Ser Ile Leu Thr Arg Tyr Glu Pro Tyr Val Ala Pro Ile
        35                  40                  45              
Ile Phe Thr Leu Leu Ser Phe Phe Thr Arg Met Tyr Lys Ile Gly Ile
    50                  55                  60                  
Asn Asn His Val Val Trp Asp Glu Ala His Phe Gly Lys Phe Gly Ser
65                  70                  75                  80  
Tyr Tyr Leu Arg His Glu Phe Tyr His Asp Val His Pro Pro Leu Gly
                85                  90                  95      
Lys Met Leu Val Gly Leu Ser Gly Tyr Ile Ala Gly Tyr Asn Gly Ser
            100                 105                 110         
Trp Asp Phe Pro Ser Gly Gln Glu Tyr Pro Asp Tyr Ile Asp Tyr Val
        115                 120                 125             
Lys Met Arg Leu Phe Asn Ala Thr Phe Ser Ala Leu Cys Val Pro Phe
    130                 135                 140                 
Ala Tyr Phe Thr Met Lys Glu Ile Gly Phe Asp Ile Lys Thr Thr Trp
145                 150                 155                 160 
Leu Phe Thr Leu Met Val Leu Cys Glu Thr Ser Tyr Cys Thr Leu Gly
                165                 170                 175     
Lys Phe Ile Leu Leu Asp Ser Met Leu Leu Leu Phe Thr Val Thr Thr
            180                 185                 190         
Val Phe Thr Phe Val Arg Gly Arg Ala
        195                 200     


<210> 81
<211> 165
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT4-s ER/Golgi Transmembrane Domain

<400> 81
atgataaaat caagaaagag atcgagaaaa gtttctttga acactgaaaa ggagctgaaa 60
aatagccata tttctcttgg agatgaaaga tggtacactg tgggtcttct cttggtgaca 120
atcacagctt tctgtactcg attctatgct atcaacgggc gcgcc                 165

<210> 82
<211> 55
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT4-s ER/Golgi Transmembrane Domain

<400> 82
Met Ile Lys Ser Arg Lys Arg Ser Arg Lys Val Ser Leu Asn Thr Glu
 1               5                  10                  15      
Lys Glu Leu Lys Asn Ser His Ile Ser Leu Gly Asp Glu Arg Trp Tyr
            20                  25                  30          
Thr Val Gly Leu Leu Leu Val Thr Ile Thr Ala Phe Cys Thr Arg Phe
        35                  40                  45              
Tyr Ala Ile Asn Gly Arg Ala
    50                  55  


<210> 83
<211> 129
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT5-s ER/Golgi Transmembrane Domain

<400> 83
atgacattct tcttattaga ctgcctagtt ttgtataatc ttacagaaat tctagctcaa 60
gccctcttac ttgttcttct tctatgtcaa ctgattcctc aatatatgtg gttggtggcc 120
gggcgcgcc                                                         129

<210> 84
<211> 43
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT5-s ER/Golgi Transmembrane Domain

<400> 84
Met Thr Phe Phe Leu Leu Asp Cys Leu Val Leu Tyr Asn Leu Thr Glu
 1               5                  10                  15      
Ile Leu Ala Gln Ala Leu Leu Leu Val Leu Leu Leu Cys Gln Leu Ile
            20                  25                  30          
Pro Gln Tyr Met Trp Leu Val Ala Gly Arg Ala
        35                  40              


<210> 85
<211> 216
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT6-s ER/Golgi Transmembrane Domain

<400> 85
atggcaacag aggaagagag aaatgaactg agaagtcgga tggacgccaa taattcaaaa 60
gtttccacgt tcactacgaa caattcagat gatccttctg ttgatagcca gggtaaggtg 120
aaaattaagt catgggtttg gagccttgaa tctttaattg gccctctggt gatcactgcc 180
ttggcaattt ttcttcgagt ttaccaaggg cgcgcc                           216

<210> 86
<211> 72
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT6-s ER/Golgi Transmembrane Domain

<400> 86
Met Ala Thr Glu Glu Glu Arg Asn Glu Leu Arg Ser Arg Met Asp Ala
 1               5                  10                  15      
Asn Asn Ser Lys Val Ser Thr Phe Thr Thr Asn Asn Ser Asp Asp Pro
            20                  25                  30          
Ser Val Asp Ser Gln Gly Lys Val Lys Ile Lys Ser Trp Val Trp Ser
        35                  40                  45              
Leu Glu Ser Leu Ile Gly Pro Leu Val Ile Thr Ala Leu Ala Ile Phe
    50                  55                  60                  
Leu Arg Val Tyr Gln Gly Arg Ala
65                  70          


<210> 87
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT1-m ER/Golgi Transmembrane Domain

<400> 87
atgtgccaga tatttctccc gcaaaacgta acacgttgtt ctgtttccct tttgacaatg 60
agtaaaacaa gtcctcaaga ggtgccagaa aacactactg agcttaaaat ctcaaaagga 120
gagctccgtc cttttattgt gacctctcca tctcctcaat tgagcaagtc tcgttctgtg 180
acttcaacca aggagaagct gatattggct agtttgttca tatttgcaat ggtcatcagg 240
ttccacaacg tcgcccaccc tgacagcgtt gtgtttgatg aagttcactt tggggggttt 300
gccagaaagt acattttggg aacctttttc atggatgttc atccgccatt ggccaagcta 360
ttatttgctg gtgttggcag tcttggtgga gggcgcgcc                        399

<210> 88
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT1-m ER/Golgi Transmembrane Domain

<400> 88
Met Cys Gln Ile Phe Leu Pro Gln Asn Val Thr Arg Cys Ser Val Ser
 1               5                  10                  15      
Leu Leu Thr Met Ser Lys Thr Ser Pro Gln Glu Val Pro Glu Asn Thr
            20                  25                  30          
Thr Glu Leu Lys Ile Ser Lys Gly Glu Leu Arg Pro Phe Ile Val Thr
        35                  40                  45              
Ser Pro Ser Pro Gln Leu Ser Lys Ser Arg Ser Val Thr Ser Thr Lys
    50                  55                  60                  
Glu Lys Leu Ile Leu Ala Ser Leu Phe Ile Phe Ala Met Val Ile Arg
65                  70                  75                  80  
Phe His Asn Val Ala His Pro Asp Ser Val Val Phe Asp Glu Val His
                85                  90                  95      
Phe Gly Gly Phe Ala Arg Lys Tyr Ile Leu Gly Thr Phe Phe Met Asp
            100                 105                 110         
Val His Pro Pro Leu Ala Lys Leu Leu Phe Ala Gly Val Gly Ser Leu
        115                 120                 125             
Gly Gly Gly Arg Ala
    130             


<210> 89
<211> 639
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT2-m ER/Golgi Transmembrane Domain

<400> 89
atgacaggcc gtgtcgacca gaaatctgat cagaaggtga aggaattgat cgaaaagatc 60
gactccgaat ccacttccag agtttttcag gaagaaccag tcacttcgat cttgacacgt 120
tacgaaccct atgtcgcccc aattatattc acgttgttgt cctttttcac tcgtatgtac 180
aaaattggga tcaacaacca cgtcgtttgg gatgaagctc acttcggaaa gtttggctcc 240
tactatctca gacacgagtt ctaccacgat gtccaccctc cgttgggtaa gatgttggtc 300
ggtctatctg gctacattgc cggttacaat ggctcctggg atttcccctc cggtcaagag 360
taccctgact atattgatta cgttaaaatg aggttattca atgccacctt cagtgcctta 420
tgtgtgccat tcgcctattt caccatgaag gagattggat ttgatatcaa gacaacttgg 480
ctattcacac tgatggtctt gtgtgaaaca agttattgta cgttaggaaa attcatcttg 540
ctggattcaa tgctgctgct attcactgtg actacggttt tcacctttgt taggttccat 600
aacgaaaaca gtaaaccagg aaactcgttt gggcgcgcc                        639

<210> 90
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT2-m ER/Golgi Transmembrane Domain

<400> 90
Met Thr Gly Arg Val Asp Gln Lys Ser Asp Gln Lys Val Lys Glu Leu
 1               5                  10                  15      
Ile Glu Lys Ile Asp Ser Glu Ser Thr Ser Arg Val Phe Gln Glu Glu
            20                  25                  30          
Pro Val Thr Ser Ile Leu Thr Arg Tyr Glu Pro Tyr Val Ala Pro Ile
        35                  40                  45              
Ile Phe Thr Leu Leu Ser Phe Phe Thr Arg Met Tyr Lys Ile Gly Ile
    50                  55                  60                  
Asn Asn His Val Val Trp Asp Glu Ala His Phe Gly Lys Phe Gly Ser
65                  70                  75                  80  
Tyr Tyr Leu Arg His Glu Phe Tyr His Asp Val His Pro Pro Leu Gly
                85                  90                  95      
Lys Met Leu Val Gly Leu Ser Gly Tyr Ile Ala Gly Tyr Asn Gly Ser
            100                 105                 110         
Trp Asp Phe Pro Ser Gly Gln Glu Tyr Pro Asp Tyr Ile Asp Tyr Val
        115                 120                 125             
Lys Met Arg Leu Phe Asn Ala Thr Phe Ser Ala Leu Cys Val Pro Phe
    130                 135                 140                 
Ala Tyr Phe Thr Met Lys Glu Ile Gly Phe Asp Ile Lys Thr Thr Trp
145                 150                 155                 160 
Leu Phe Thr Leu Met Val Leu Cys Glu Thr Ser Tyr Cys Thr Leu Gly
                165                 170                 175     
Lys Phe Ile Leu Leu Asp Ser Met Leu Leu Leu Phe Thr Val Thr Thr
            180                 185                 190         
Val Phe Thr Phe Val Arg Phe His Asn Glu Asn Ser Lys Pro Gly Asn
        195                 200                 205             
Ser Phe Gly Arg Ala
    210             


<210> 91
<211> 204
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT4-m ER/Golgi Transmembrane Domain

<400> 91
atgataaaat caagaaagag atcgagaaaa gtttctttga acactgaaaa ggagctgaaa 60
aatagccata tttctcttgg agatgaaaga tggtacactg tgggtcttct cttggtgaca 120
atcacagctt tctgtactcg attctatgct atcaactatc cagatgaggt tgtttttgac 180
gaagttcatt tcggagggcg cgcc                                        204

<210> 92
<211> 68
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT4-m ER/Golgi Transmembrane Domain

<400> 92
Met Ile Lys Ser Arg Lys Arg Ser Arg Lys Val Ser Leu Asn Thr Glu
 1               5                  10                  15      
Lys Glu Leu Lys Asn Ser His Ile Ser Leu Gly Asp Glu Arg Trp Tyr
            20                  25                  30          
Thr Val Gly Leu Leu Leu Val Thr Ile Thr Ala Phe Cys Thr Arg Phe
        35                  40                  45              
Tyr Ala Ile Asn Tyr Pro Asp Glu Val Val Phe Asp Glu Val His Phe
    50                  55                  60                  
Gly Gly Arg Ala
65              


<210> 93
<211> 249
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT5-m ER/Golgi Transmembrane Domain

<400> 93
atgacattct tcttattaga ctgcctagtt ttgtataatc ttacagaaat tctagctcaa 60
gccctcttac ttgttcttct tctatgtcaa ctgattcctc aatatatgtg gttggtggcc 120
cgcgaaatga ctcctgagat atttggtcaa acctaccaaa ggacaccaca ccacagtact 180
atagcacaac aatacatggc cgcctttgag tacaaaaagg gcattcaaag accctatttt 240
gggcgcgcc                                                         249

<210> 94
<211> 83
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT5-m ER/Golgi Transmembrane Domain

<400> 94
Met Thr Phe Phe Leu Leu Asp Cys Leu Val Leu Tyr Asn Leu Thr Glu
 1               5                  10                  15      
Ile Leu Ala Gln Ala Leu Leu Leu Val Leu Leu Leu Cys Gln Leu Ile
            20                  25                  30          
Pro Gln Tyr Met Trp Leu Val Ala Arg Glu Met Thr Pro Glu Ile Phe
        35                  40                  45              
Gly Gln Thr Tyr Gln Arg Thr Pro His His Ser Thr Ile Ala Gln Gln
    50                  55                  60                  
Tyr Met Ala Ala Phe Glu Tyr Lys Lys Gly Ile Gln Arg Pro Tyr Phe
65                  70                  75                  80  
Gly Arg Ala
            


<210> 95
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpPMT6-m ER/Golgi Transmembrane Domain

<400> 95
atggcaacag aggaagagag aaatgaactg agaagtcgga tggacgccaa taattcaaaa 60
gtttccacgt tcactacgaa caattcagat gatccttctg ttgatagcca gggtaaggtg 120
aaaattaagt catgggtttg gagccttgaa tctttaattg gccctctggt gatcactgcc 180
ttggcaattt ttcttcgagt ttaccaaata ggaaaagctg atagggttgt ttgggatgaa 240
gctcatttcg gaaagtttgg gtcattctac ttgaagcacc agttctattt tgatgtccat 300
cctcccctgg gaaaacttct tacaggtttg gggcgcgcc                        339

<210> 96
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpPMT6-m ER/Golgi Transmembrane Domain

<400> 96
Met Ala Thr Glu Glu Glu Arg Asn Glu Leu Arg Ser Arg Met Asp Ala
 1               5                  10                  15      
Asn Asn Ser Lys Val Ser Thr Phe Thr Thr Asn Asn Ser Asp Asp Pro
            20                  25                  30          
Ser Val Asp Ser Gln Gly Lys Val Lys Ile Lys Ser Trp Val Trp Ser
        35                  40                  45              
Leu Glu Ser Leu Ile Gly Pro Leu Val Ile Thr Ala Leu Ala Ile Phe
    50                  55                  60                  
Leu Arg Val Tyr Gln Ile Gly Lys Ala Asp Arg Val Val Trp Asp Glu
65                  70                  75                  80  
Ala His Phe Gly Lys Phe Gly Ser Phe Tyr Leu Lys His Gln Phe Tyr
                85                  90                  95      
Phe Asp Val His Pro Pro Leu Gly Lys Leu Leu Thr Gly Leu Gly Arg
            100                 105                 110         
Ala
    


<210> 97
<211> 99
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScBOS1-s ER/Golgi Transmembrane Domain

<400> 97
atgaacgctc tttacaacca tgctgtgaag caaaaaaatc aactacaaca agagttggcc 60
aggtttgaaa agaattctgt gaccgcccct gggcgcgcc                        99

<210> 98
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScBOS1-s ER/Golgi Transmembrane Domain

<400> 98
Met Asn Ala Leu Tyr Asn His Ala Val Lys Gln Lys Asn Gln Leu Gln
 1               5                  10                  15      
Gln Glu Leu Ala Arg Phe Glu Lys Asn Ser Val Thr Ala Pro Gly Arg
            20                  25                  30          
Ala
    


<210> 99
<211> 108
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScBET1-s ER/Golgi Transmembrane Domain

<400> 99
atgagttcaa gatttgcagg gggaaacgct tatcaacgtg atactggtag aacacagtta 60
ttcggaccgg ctgatggatc aaatagtctc gatgacaatg ggcgcgcc              108

<210> 100
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScBET1-s ER/Golgi Transmembrane Domain

<400> 100
Met Ser Ser Arg Phe Ala Gly Gly Asn Ala Tyr Gln Arg Asp Thr Gly
 1               5                  10                  15      
Arg Thr Gln Leu Phe Gly Pro Ala Asp Gly Ser Asn Ser Leu Asp Asp
            20                  25                  30          
Asn Gly Arg Ala
        35      


<210> 101
<211> 114
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScSEC22-s ER/Golgi Transmembrane Domain

<400> 101
atgtccgcgc aaaagatcaa cttcgatctc ttgatcagtc aatatgctcc tattgtcatt 60
gtcgctttct ttttcgtctt tctcttctgg tggatcttcc tcaaagggcg cgcc       114

<210> 102
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> ScSEC22-s ER/Golgi Transmembrane Domain

<400> 102
Met Ser Ala Gln Lys Ile Asn Phe Asp Leu Leu Ile Ser Gln Tyr Ala
 1               5                  10                  15      
Pro Ile Val Ile Val Ala Phe Phe Phe Val Phe Leu Phe Trp Trp Ile
            20                  25                  30          
Phe Leu Lys Gly Arg Ala
        35              


<210> 103
<211> 96
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpBOS1-s ER/Golgi Transmembrane Domain

<400> 103
atgaaggcat ttgaagacaa gtggattttt tatggtggcg ctataagtgt ttttgttatt 60
ttctatttgg cggtcaaata tttaagaggg cgcgcc                           96

<210> 104
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpBOS1-s ER/Golgi Transmembrane Domain

<400> 104
Met Lys Ala Phe Glu Asp Lys Trp Ile Phe Tyr Gly Gly Ala Ile Ser
 1               5                  10                  15      
Val Phe Val Ile Phe Tyr Leu Ala Val Lys Tyr Leu Arg Gly Arg Ala
            20                  25                  30          


<210> 105
<211> 111
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpBET1-s ER/Golgi Transmembrane Domain

<400> 105
atgaggatga tggtaatggc taagaaaaca ggtatttcat ggaagttatg gctgctgttc 60
ttcttcctcg tctggctttg gttctttttt gtgtggctta gagggcgcgc c          111

<210> 106
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpBET1-s ER/Golgi Transmembrane Domain

<400> 106
Met Arg Met Met Val Met Ala Lys Lys Thr Gly Ile Ser Trp Lys Leu
 1               5                  10                  15      
Trp Leu Leu Phe Phe Phe Leu Val Trp Leu Trp Phe Phe Phe Val Trp
            20                  25                  30          
Leu Arg Gly Arg Ala
        35          


<210> 107
<211> 114
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpSEC22-s ER/Golgi Transmembrane Domain

<400> 107
atggcagctc gaagaatcaa tttggaggct ctgataaaac agtacgttcc ggttgcaatg 60
gtggggattt tcttcgtatt tataatatgg tggatattct tgcgcgggcg cgcc       114

<210> 108
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> PpSEC22-s ER/Golgi Transmembrane Domain

<400> 108
Met Ala Ala Arg Arg Ile Asn Leu Glu Ala Leu Ile Lys Gln Tyr Val
 1               5                  10                  15      
Pro Val Ala Met Val Gly Ile Phe Phe Val Phe Ile Ile Trp Trp Ile
            20                  25                  30          
Phe Leu Arg Gly Arg Ala
        35              


<210> 109
<211> 1809
<212> DNA
<213> Human

<400> 109
cgcgccattt ctgaagctaa cgaggaccct gaaccagaac aagattacga cgaggctttg 60
ggaagattgg aaccaccaag aagaagaggt tccggtccaa gaagagtttt ggacgttgag 120
gtttactctt ccagatccaa ggtttacgtt gctgttgacg gtactactgt tttggaggac 180
gaggctagag aacaaggtag aggtatccac gttatcgttt tgaaccaggc tactggtcat 240
gttatggcta agagagtttt cgacacttac tctccacacg aagatgaggc tatggttttg 300
ttcttgaaca tggttgctcc aggtagagtt ttgatttgta ctgttaagga cgagggatcc 360
ttccatttga aggacactgc taaggctttg ttgagatcct tgggttctca agctggtcca 420
gctttgggat ggagagatac ttgggctttc gttggtagaa agggtggtcc agttttcggt 480
gaaaagcact ctaagtcccc agctttgtcc tcttggggtg acccagtttt gttgaaaact 540
gacgttccat tgtcctctgc tgaagaggct gaatgtcact gggctgacac tgagttgaac 600
agaagaagaa gaagattctg ttccaaggtt gagggttacg gttctgtttg ttcctgtaag 660
gacccaactc caattgaatt ctccccagac ccattgccag ataacaaggt tttgaacgtt 720
ccagttgctg ttatcgctgg taacagacca aactacttgt acagaatgtt gagatctttg 780
ttgtccgctc agggagtttc tccacagatg atcactgttt tcatcgacgg ttactacgaa 840
gaaccaatgg acgttgttgc tttgttcgga ttgagaggta ttcagcacac tccaatctcc 900
atcaagaacg ctagagtttc ccaacactac aaggcttcct tgactgctac tttcaacttg 960
ttcccagagg ctaagttcgc tgttgttttg gaagaggact tggacattgc tgttgatttc 1020
ttctccttct tgtcccaatc catccacttg ttggaagagg atgactcctt gtactgtatc 1080
tctgcttgga acgaccaagg ttacgaacac actgctgagg atccagcttt gttgtacaga 1140
gttgagacta tgccaggatt gggatgggtt ttgagaagat ccttgtacaa agaagagttg 1200
gagccaaagt ggccaactcc agaaaagttg tgggattggg acatgtggat gagaatgcca 1260
gagcagagaa gaggtagaga gtgtatcatc ccagacgttt ccagatctta ccacttcggt 1320
attgttggat tgaacatgaa cggttacttc cacgaggctt acttcaagaa gcacaagttc 1380
aacactgttc caggtgttca gttgagaaac gttgactcct tgaagaaaga ggcttacgag 1440
gttgaggttc acagattgtt gtctgaggct gaggttttgg accattccaa gaacccatgt 1500
gaggactcat tcttgccaga tactgagggt catacttacg ttgctttcat cagaatggaa 1560
aaggacgacg acttcactac ttggactcag ttggctaagt gtttgcacat ttgggacttg 1620
gatgttagag gtaaccacag aggattgtgg agattgttca gaaagaagaa ccacttcttg 1680
gttgttggtg ttccagcttc tccatactcc gttaagaagc caccatccgt tactccaatt 1740
ttcttggagc caccaccaaa ggaagaaggt gctcctggtg ctccagagca aacttaatag 1800
ttaattaaa                                                         1809

<210> 110
<211> 598
<212> PRT
<213> Human

<400> 110
Arg Ala Ile Ser Glu Ala Asn Glu Asp Pro Glu Pro Glu Gln Asp Tyr
 1               5                  10                  15      
Asp Glu Ala Leu Gly Arg Leu Glu Pro Pro Arg Arg Arg Gly Ser Gly
            20                  25                  30          
Pro Arg Arg Val Leu Asp Val Glu Val Tyr Ser Ser Arg Ser Lys Val
        35                  40                  45              
Tyr Val Ala Val Asp Gly Thr Thr Val Leu Glu Asp Glu Ala Arg Glu
    50                  55                  60                  
Gln Gly Arg Gly Ile His Val Ile Val Leu Asn Gln Ala Thr Gly His
65                  70                  75                  80  
Val Met Ala Lys Arg Val Phe Asp Thr Tyr Ser Pro His Glu Asp Glu
                85                  90                  95      
Ala Met Val Leu Phe Leu Asn Met Val Ala Pro Gly Arg Val Leu Ile
            100                 105                 110         
Cys Thr Val Lys Asp Glu Gly Ser Phe His Leu Lys Asp Thr Ala Lys
        115                 120                 125             
Ala Leu Leu Arg Ser Leu Gly Ser Gln Ala Gly Pro Ala Leu Gly Trp
    130                 135                 140                 
Arg Asp Thr Trp Ala Phe Val Gly Arg Lys Gly Gly Pro Val Phe Gly
145                 150                 155                 160 
Glu Lys His Ser Lys Ser Pro Ala Leu Ser Ser Trp Gly Asp Pro Val
                165                 170                 175     
Leu Leu Lys Thr Asp Val Pro Leu Ser Ser Ala Glu Glu Ala Glu Cys
            180                 185                 190         
His Trp Ala Asp Thr Glu Leu Asn Arg Arg Arg Arg Arg Phe Cys Ser
        195                 200                 205             
Lys Val Glu Gly Tyr Gly Ser Val Cys Ser Cys Lys Asp Pro Thr Pro
    210                 215                 220                 
Ile Glu Phe Ser Pro Asp Pro Leu Pro Asp Asn Lys Val Leu Asn Val
225                 230                 235                 240 
Pro Val Ala Val Ile Ala Gly Asn Arg Pro Asn Tyr Leu Tyr Arg Met
                245                 250                 255     
Leu Arg Ser Leu Leu Ser Ala Gln Gly Val Ser Pro Gln Met Ile Thr
            260                 265                 270         
Val Phe Ile Asp Gly Tyr Tyr Glu Glu Pro Met Asp Val Val Ala Leu
        275                 280                 285             
Phe Gly Leu Arg Gly Ile Gln His Thr Pro Ile Ser Ile Lys Asn Ala
    290                 295                 300                 
Arg Val Ser Gln His Tyr Lys Ala Ser Leu Thr Ala Thr Phe Asn Leu
305                 310                 315                 320 
Phe Pro Glu Ala Lys Phe Ala Val Val Leu Glu Glu Asp Leu Asp Ile
                325                 330                 335     
Ala Val Asp Phe Phe Ser Phe Leu Ser Gln Ser Ile His Leu Leu Glu
            340                 345                 350         
Glu Asp Asp Ser Leu Tyr Cys Ile Ser Ala Trp Asn Asp Gln Gly Tyr
        355                 360                 365             
Glu His Thr Ala Glu Asp Pro Ala Leu Leu Tyr Arg Val Glu Thr Met
    370                 375                 380                 
Pro Gly Leu Gly Trp Val Leu Arg Arg Ser Leu Tyr Lys Glu Glu Leu
385                 390                 395                 400 
Glu Pro Lys Trp Pro Thr Pro Glu Lys Leu Trp Asp Trp Asp Met Trp
                405                 410                 415     
Met Arg Met Pro Glu Gln Arg Arg Gly Arg Glu Cys Ile Ile Pro Asp
            420                 425                 430         
Val Ser Arg Ser Tyr His Phe Gly Ile Val Gly Leu Asn Met Asn Gly
        435                 440                 445             
Tyr Phe His Glu Ala Tyr Phe Lys Lys His Lys Phe Asn Thr Val Pro
    450                 455                 460                 
Gly Val Gln Leu Arg Asn Val Asp Ser Leu Lys Lys Glu Ala Tyr Glu
465                 470                 475                 480 
Val Glu Val His Arg Leu Leu Ser Glu Ala Glu Val Leu Asp His Ser
                485                 490                 495     
Lys Asn Pro Cys Glu Asp Ser Phe Leu Pro Asp Thr Glu Gly His Thr
            500                 505                 510         
Tyr Val Ala Phe Ile Arg Met Glu Lys Asp Asp Asp Phe Thr Thr Trp
        515                 520                 525             
Thr Gln Leu Ala Lys Cys Leu His Ile Trp Asp Leu Asp Val Arg Gly
    530                 535                 540                 
Asn His Arg Gly Leu Trp Arg Leu Phe Arg Lys Lys Asn His Phe Leu
545                 550                 555                 560 
Val Val Gly Val Pro Ala Ser Pro Tyr Ser Val Lys Lys Pro Pro Ser
                565                 570                 575     
Val Thr Pro Ile Phe Leu Glu Pro Pro Pro Lys Glu Glu Gly Ala Pro
            580                 585                 590         
Gly Ala Pro Glu Gln Thr
        595             


<210> 111
<211> 1804
<212> DNA
<213> Mouse

<400> 111
cgcgccattt ctgaagctaa cgaggaccct gaaccagaac aagattacga cgaggctttg 60
ggaagattgg aatccccaag aagaagagga tcctccccta gaagagtttt ggacgttgag 120
gtttactctt ccagatccaa ggtttacgtt gctgttgacg gtactactgt tttggaggac 180
gaggctagag aacaaggtag aggtatccac gttatcgttt tgaaccaggc tactggtcat 240
gttatggcta agagagtttt cgacacttac tctccacacg aagatgaggc tatggttttg 300
ttcttgaaca tggttgctcc aggtagagtt ttgatttgta ctgttaagga cgagggatcc 360
ttccatttga aggacactgc taaggctttg ttgagatcct tgggttctca agctggtcca 420
gctttgggat ggagagatac ttgggctttc gttggtagaa agggtggtcc agttttgggt 480
gaaaagcact ctaagtcccc agctttgtcc tcttggggtg acccagtttt gttgaaaact 540
gacgttccat tgtcctctgc tgaagaggct gaatgtcact gggctgacac tgagttgaac 600
agaagaagaa gaagattctg ttccaaggtt gagggttacg gttctgtttg ttcctgtaag 660
gacccaactc caattgaatt ctccccagac ccattgccag ataacaaggt tttgaacgtt 720
ccagttgctg ttatcgctgg taacagacca aactacttgt acagaatgtt gagatctttg 780
ttgtccgctc agggagtttc tccacagatg atcactgttt tcatcgacgg ttactacgaa 840
gaaccaatgg acgttgttgc tttgttcgga ttgagaggta ttcagcacac tccaatctcc 900
atcaagaacg ctagagtttc ccaacactac aaggcttcct tgactgctac tttcaacttg 960
ttcccagagg ctaagttcgc tgttgttttg gaagaggact tggacattgc tgttgatttc 1020
ttctccttct tgtcccaatc catccacttg ttggaagagg atgactcctt gtactgtatc 1080
tctgcttgga acgaccaagg ttacgaacac actgctgagg atccagcttt gttgtacaga 1140
gttgagacta tgccaggatt gggatgggtt ttgagaaagt ccttgtacaa agaggagttg 1200
gagccaaagt ggccaactcc agaaaagttg tgggattggg acatgtggat gagaatgcca 1260
gagcagagaa gaggtagaga gtgtatcatc ccagacgttt ccagatctta ccacttcggt 1320
attgttggat tgaacatgaa cggttacttc cacgaggctt acttcaagaa gcacaagttc 1380
aacactgttc caggtgttca gttgagaaac gttgactcct tgaagaaaga ggcttacgag 1440
gttgagatcc acagattgtt gtctgaggct gaggttttgg atcactccaa ggatccatgt 1500
gaggactcat tcttgccaga tactgagggt catacttacg ttgctttcat cagaatggaa 1560
actgacgacg actttgctac ttggactcag ttggctaagt gtttgcacat ttgggacttg 1620
gatgttagag gtaaccacag aggattgtgg agattgttca gaaagaagaa ccacttcttg 1680
gttgttggtg ttccagcttc tccatactcc gttaagaagc caccatccgt tactccaatt 1740
ttcttggagc caccaccaaa ggaagaaggt gctcctggag ctgctgaaca aacttagtag 1800
ttaa                                                              1804

<210> 112
<211> 598
<212> PRT
<213> Mouse

<400> 112
Arg Ala Ile Ser Glu Ala Asn Glu Asp Pro Glu Pro Glu Gln Asp Tyr
 1               5                  10                  15      
Asp Glu Ala Leu Gly Arg Leu Glu Ser Pro Arg Arg Arg Gly Ser Ser
            20                  25                  30          
Pro Arg Arg Val Leu Asp Val Glu Val Tyr Ser Ser Arg Ser Lys Val
        35                  40                  45              
Tyr Val Ala Val Asp Gly Thr Thr Val Leu Glu Asp Glu Ala Arg Glu
    50                  55                  60                  
Gln Gly Arg Gly Ile His Val Ile Val Leu Asn Gln Ala Thr Gly His
65                  70                  75                  80  
Val Met Ala Lys Arg Val Phe Asp Thr Tyr Ser Pro His Glu Asp Glu
                85                  90                  95      
Ala Met Val Leu Phe Leu Asn Met Val Ala Pro Gly Arg Val Leu Ile
            100                 105                 110         
Cys Thr Val Lys Asp Glu Gly Ser Phe His Leu Lys Asp Thr Ala Lys
        115                 120                 125             
Ala Leu Leu Arg Ser Leu Gly Ser Gln Ala Gly Pro Ala Leu Gly Trp
    130                 135                 140                 
Arg Asp Thr Trp Ala Phe Val Gly Arg Lys Gly Gly Pro Val Leu Gly
145                 150                 155                 160 
Glu Lys His Ser Lys Ser Pro Ala Leu Ser Ser Trp Gly Asp Pro Val
                165                 170                 175     
Leu Leu Lys Thr Asp Val Pro Leu Ser Ser Ala Glu Glu Ala Glu Cys
            180                 185                 190         
His Trp Ala Asp Thr Glu Leu Asn Arg Arg Arg Arg Arg Phe Cys Ser
        195                 200                 205             
Lys Val Glu Gly Tyr Gly Ser Val Cys Ser Cys Lys Asp Pro Thr Pro
    210                 215                 220                 
Ile Glu Phe Ser Pro Asp Pro Leu Pro Asp Asn Lys Val Leu Asn Val
225                 230                 235                 240 
Pro Val Ala Val Ile Ala Gly Asn Arg Pro Asn Tyr Leu Tyr Arg Met
                245                 250                 255     
Leu Arg Ser Leu Leu Ser Ala Gln Gly Val Ser Pro Gln Met Ile Thr
            260                 265                 270         
Val Phe Ile Asp Gly Tyr Tyr Glu Glu Pro Met Asp Val Val Ala Leu
        275                 280                 285             
Phe Gly Leu Arg Gly Ile Gln His Thr Pro Ile Ser Ile Lys Asn Ala
    290                 295                 300                 
Arg Val Ser Gln His Tyr Lys Ala Ser Leu Thr Ala Thr Phe Asn Leu
305                 310                 315                 320 
Phe Pro Glu Ala Lys Phe Ala Val Val Leu Glu Glu Asp Leu Asp Ile
                325                 330                 335     
Ala Val Asp Phe Phe Ser Phe Leu Ser Gln Ser Ile His Leu Leu Glu
            340                 345                 350         
Glu Asp Asp Ser Leu Tyr Cys Ile Ser Ala Trp Asn Asp Gln Gly Tyr
        355                 360                 365             
Glu His Thr Ala Glu Asp Pro Ala Leu Leu Tyr Arg Val Glu Thr Met
    370                 375                 380                 
Pro Gly Leu Gly Trp Val Leu Arg Lys Ser Leu Tyr Lys Glu Glu Leu
385                 390                 395                 400 
Glu Pro Lys Trp Pro Thr Pro Glu Lys Leu Trp Asp Trp Asp Met Trp
                405                 410                 415     
Met Arg Met Pro Glu Gln Arg Arg Gly Arg Glu Cys Ile Ile Pro Asp
            420                 425                 430         
Val Ser Arg Ser Tyr His Phe Gly Ile Val Gly Leu Asn Met Asn Gly
        435                 440                 445             
Tyr Phe His Glu Ala Tyr Phe Lys Lys His Lys Phe Asn Thr Val Pro
    450                 455                 460                 
Gly Val Gln Leu Arg Asn Val Asp Ser Leu Lys Lys Glu Ala Tyr Glu
465                 470                 475                 480 
Val Glu Ile His Arg Leu Leu Ser Glu Ala Glu Val Leu Asp His Ser
                485                 490                 495     
Lys Asp Pro Cys Glu Asp Ser Phe Leu Pro Asp Thr Glu Gly His Thr
            500                 505                 510         
Tyr Val Ala Phe Ile Arg Met Glu Thr Asp Asp Asp Phe Ala Thr Trp
        515                 520                 525             
Thr Gln Leu Ala Lys Cys Leu His Ile Trp Asp Leu Asp Val Arg Gly
    530                 535                 540                 
Asn His Arg Gly Leu Trp Arg Leu Phe Arg Lys Lys Asn His Phe Leu
545                 550                 555                 560 
Val Val Gly Val Pro Ala Ser Pro Tyr Ser Val Lys Lys Pro Pro Ser
                565                 570                 575     
Val Thr Pro Ile Phe Leu Glu Pro Pro Pro Lys Glu Glu Gly Ala Pro
            580                 585                 590         
Gly Ala Ala Glu Gln Thr
        595             


<210> 113
<211> 1616
<212> DNA
<213> Chicken

<400> 113
cgcgccgctt atgaagaaga ggaagagtcc gctcaagatt acgacgacga gatgttgaat 60
gttgaggctc caagacaccc agtttccaac aagaaggttt tggacgttga ggtttactct 120
tccagatcca aggtttacgt tgctgttgac ggtactactg ttttggagga cgaggctaga 180
gaacaaggta gaggtatcca cgttatcgtt ttgaaccagg ctactggtca tgttatggct 240
aagagagttt tcgacactta ctctccacac gaagatgagg ctatggtttt gttcttgaac 300
atggttgcta gaggtagaat cttgatcttc actatcaagg acgagggatc cttccacttg 360
aaagagactg ctaagaacgt tttgaagtcc ttgggttccc aagttgctcc attcttgtct 420
tggagagaca tgtggacttt tgttggaaag aagggtggag aagtttacgg tgaaaagcac 480
gctaagtctc cagctttgtc tacttggggt gacccagttt tgttgaaaac tgaggttcac 540
ttgacttccg ttgaggatgc tgaatgtcac tggccagaca ctgagttgaa cagaagaaga 600
agaagattct gttccaaggt tgagggttac ggttctgttt gttcctgtaa ggacccaact 660
ccaatcgaat tcaacccaga cccattgaag gacaacaagg ttttcgatgt tccagttgct 720
gttatcgctg gtaacagacc aaactacttg tacagaatgt tgagatcctt gttgtccgct 780
caaggtgtta acccacagat gatcactgtt ttcatcgacg gttactacga agaaccaatg 840
gacgttgttg agttgttcgg tttgtccggt attcaacaca ctccaatctc catcaagaac 900
gctagagttt cccaacacta caaggcttcc ttgactgcta ctttcaactt gttcccagac 960
gctaagttcg ctgttgtttt ggaagaggac ttggacattt ccgttgattt cttctccttc 1020
ttgtcccaat ccatccactt gttggaagag gatgagtcct tgtactgtat ctctgcttgg 1080
aacgaccaag gttacgaaca cactgctgag gatccatcct tgttgtacag agttgagact 1140
atgccaggat tgggatgggt tttgagaaag tcattgtata aggacgaatt ggaaccaaag 1200
tggccaactc cagaaaagtt gtgggattgg gacatgtgga tgagaatgcc agagcagaga 1260
aagggtagag agtgtatcat tccagacatc tccagatctt accacttcgg tattgttgga 1320
ttgaacatga acggttactt ccacgaggct tacttcaaga agcacaagtt caacactgtt 1380
ccaaacgttc agttgaagaa cgttgagtcc ttgagaaagg acgcttacga agctgagatc 1440
cacagattgt tgggtgaagc tgaggttttg gaccactcca agaacccatg tgaggattct 1500
ttcgttcctg acactgaggg taaagtttac gttatgttca tcaagatgga acaagaggct 1560
gacttcacta cttggactca gttggctaaa gaattgatgg cttagtagtt aattaa     1616

<210> 114
<211> 534
<212> PRT
<213> Chicken

<400> 114
Arg Ala Ala Tyr Glu Glu Glu Glu Glu Ser Ala Gln Asp Tyr Asp Asp
 1               5                  10                  15      
Glu Met Leu Asn Val Glu Ala Pro Arg His Pro Val Ser Asn Lys Lys
            20                  25                  30          
Val Leu Asp Val Glu Val Tyr Ser Ser Arg Ser Lys Val Tyr Val Ala
        35                  40                  45              
Val Asp Gly Thr Thr Val Leu Glu Asp Glu Ala Arg Glu Gln Gly Arg
    50                  55                  60                  
Gly Ile His Val Ile Val Leu Asn Gln Ala Thr Gly His Val Met Ala
65                  70                  75                  80  
Lys Arg Val Phe Asp Thr Tyr Ser Pro His Glu Asp Glu Ala Met Val
                85                  90                  95      
Leu Phe Leu Asn Met Val Ala Arg Gly Arg Ile Leu Ile Phe Thr Ile
            100                 105                 110         
Lys Asp Glu Gly Ser Phe His Leu Lys Glu Thr Ala Lys Asn Val Leu
        115                 120                 125             
Lys Ser Leu Gly Ser Gln Val Ala Pro Phe Leu Ser Trp Arg Asp Met
    130                 135                 140                 
Trp Thr Phe Val Gly Lys Lys Gly Gly Glu Val Tyr Gly Glu Lys His
145                 150                 155                 160 
Ala Lys Ser Pro Ala Leu Ser Thr Trp Gly Asp Pro Val Leu Leu Lys
                165                 170                 175     
Thr Glu Val His Leu Thr Ser Val Glu Asp Ala Glu Cys His Trp Pro
            180                 185                 190         
Asp Thr Glu Leu Asn Arg Arg Arg Arg Arg Phe Cys Ser Lys Val Glu
        195                 200                 205             
Gly Tyr Gly Ser Val Cys Ser Cys Lys Asp Pro Thr Pro Ile Glu Phe
    210                 215                 220                 
Asn Pro Asp Pro Leu Lys Asp Asn Lys Val Phe Asp Val Pro Val Ala
225                 230                 235                 240 
Val Ile Ala Gly Asn Arg Pro Asn Tyr Leu Tyr Arg Met Leu Arg Ser
                245                 250                 255     
Leu Leu Ser Ala Gln Gly Val Asn Pro Gln Met Ile Thr Val Phe Ile
            260                 265                 270         
Asp Gly Tyr Tyr Glu Glu Pro Met Asp Val Val Glu Leu Phe Gly Leu
        275                 280                 285             
Ser Gly Ile Gln His Thr Pro Ile Ser Ile Lys Asn Ala Arg Val Ser
    290                 295                 300                 
Gln His Tyr Lys Ala Ser Leu Thr Ala Thr Phe Asn Leu Phe Pro Asp
305                 310                 315                 320 
Ala Lys Phe Ala Val Val Leu Glu Glu Asp Leu Asp Ile Ser Val Asp
                325                 330                 335     
Phe Phe Ser Phe Leu Ser Gln Ser Ile His Leu Leu Glu Glu Asp Glu
            340                 345                 350         
Ser Leu Tyr Cys Ile Ser Ala Trp Asn Asp Gln Gly Tyr Glu His Thr
        355                 360                 365             
Ala Glu Asp Pro Ser Leu Leu Tyr Arg Val Glu Thr Met Pro Gly Leu
    370                 375                 380                 
Gly Trp Val Leu Arg Lys Ser Leu Tyr Lys Asp Glu Leu Glu Pro Lys
385                 390                 395                 400 
Trp Pro Thr Pro Glu Lys Leu Trp Asp Trp Asp Met Trp Met Arg Met
                405                 410                 415     
Pro Glu Gln Arg Lys Gly Arg Glu Cys Ile Ile Pro Asp Ile Ser Arg
            420                 425                 430         
Ser Tyr His Phe Gly Ile Val Gly Leu Asn Met Asn Gly Tyr Phe His
        435                 440                 445             
Glu Ala Tyr Phe Lys Lys His Lys Phe Asn Thr Val Pro Asn Val Gln
    450                 455                 460                 
Leu Lys Asn Val Glu Ser Leu Arg Lys Asp Ala Tyr Glu Ala Glu Ile
465                 470                 475                 480 
His Arg Leu Leu Gly Glu Ala Glu Val Leu Asp His Ser Lys Asn Pro
                485                 490                 495     
Cys Glu Asp Ser Phe Val Pro Asp Thr Glu Gly Lys Val Tyr Val Met
            500                 505                 510         
Phe Ile Lys Met Glu Gln Glu Ala Asp Phe Thr Thr Trp Thr Gln Leu
        515                 520                 525             
Ala Lys Glu Leu Met Ala
    530                 


<210> 115
<211> 1781
<212> DNA
<213> Zebrafish

<400> 115
cgccgcttct gaagatgatg ctgctcaaga atacgatgac gctttgccaa acatggaaac 60
tccaagaaga ccagcttccg gtagaaaggt tttggacatc gaggtttact cttccagatc 120
caaggtttac gttgctgttg acggtactac tgttttggag gacgagatta gagaacaggg 180
tagaggtatc cacgttatcg ttttgaacca ggctactggt catgttatgg ctaagagagt 240
tttcgacact tactctccac acgaagatga ggctatgatc ttgttcttga acatggttac 300
tagaggtaga atcttgatct tcactatcaa ggacgaggga actttccatt tgaaggacgc 360
tgctaagaac ttgttgaagg gattgggttc ccaagttgct gttactttgg gatggagaga 420
catgtggact ttggttgtta agaagggtgg acaggtttac ggtgaaaagc actctaagtc 480
cccagctttg tctacttggg gtgacccagt tttgttgaaa actgaggttc agttgactgc 540
ttctgaagag gctgaatgtc actgggctga cactgagttg aacagaagaa gaaagttgtt 600
ctgttccaag gttgaaggtt acggttctat ctgttcctgt aaggacccag ctccaattga 660
attcaaccca gatccattgt ccaacaacaa cgtttacaac atccctgttg ctgttatcgc 720
tggtaacaga ccaaactact tgtacagaat gttgagatcc ttgttgtcct ctcacggtgt 780
taacccacag atgatcactg ttttcatcga cggttactac gaagaaccaa tggacgttgt 840
tgacttgttc ggattgaagg gtgttcaaca cactccaatc tccatcaaga acgctagagt 900
ttcccaacac tacaaggctt ccttgactgc tactttcaac ttgcacccag atgctgactt 960
cgctatcgtt ttggaagagg acttggacat ttccatcgat ttcttctcat tcttgggaca 1020
gactatccac ttgttgcacg aggacgattc cttgtactgt atctccgctt ggaacgacca 1080
aggttacgaa cacactgctg aggatccatc cttgttgtac agagttgagt ccatgccagg 1140
attgggatgg gttttgaaga agtcattgta taaggacgaa ttggaaccaa agtggccaac 1200
tccagaaaag ttgtgggatt gggacatgtg gatgagaatg ccagagcaga gaaagggaag 1260
agagtgtgtt attccagacg tttccagatc ttaccacttc ggtatcatcg gattgaacat 1320
gaacggttac ttccacgagg tttacttcaa gaagcacaag ttcaacacta tcccaaacgt 1380
tcagatgaag aacgttgaga acttgaagaa ggacccatac gagattgaga tccaaaactt 1440
gttgagagag gctgaagttt tggaccactc caagaaccca tgtgaggatt ccttcatccc 1500
agacactgag ggaaagactt tcgttatgtt catcaagatg gaacaagaga ctgacactaa 1560
cacttggact gagttggcta agtgtttgca tgtttgggac ttggatgtta gaggttacca 1620
caagggtttg tggagattgt tcagaaagaa gaaccacatc ttggttgttg ctttcccaat 1680
ttccccatac tccgttaaga agccatccaa cgttactcca atccacttgg aaccagctcc 1740
aaaagaagaa ggtccaccag ttgagcagat gtagtagtta a                     1781

<210> 116
<211> 590
<212> PRT
<213> Zebrafish

<400> 116
Arg Ala Ala Ser Glu Asp Asp Ala Ala Gln Glu Tyr Asp Asp Ala Leu
 1               5                  10                  15      
Pro Asn Met Glu Thr Pro Arg Arg Pro Ala Ser Gly Arg Lys Val Leu
            20                  25                  30          
Asp Ile Glu Val Tyr Ser Ser Arg Ser Lys Val Tyr Val Ala Val Asp
        35                  40                  45              
Gly Thr Thr Val Leu Glu Asp Glu Ile Arg Glu Gln Gly Arg Gly Ile
    50                  55                  60                  
His Val Ile Val Leu Asn Gln Ala Thr Gly His Val Met Ala Lys Arg
65                  70                  75                  80  
Val Phe Asp Thr Tyr Ser Pro His Glu Asp Glu Ala Met Ile Leu Phe
                85                  90                  95      
Leu Asn Met Val Thr Arg Gly Arg Ile Leu Ile Phe Thr Ile Lys Asp
            100                 105                 110         
Glu Gly Thr Phe His Leu Lys Asp Ala Ala Lys Asn Leu Leu Lys Gly
        115                 120                 125             
Leu Gly Ser Gln Val Ala Val Thr Leu Gly Trp Arg Asp Met Trp Thr
    130                 135                 140                 
Leu Val Val Lys Lys Gly Gly Gln Val Tyr Gly Glu Lys His Ser Lys
145                 150                 155                 160 
Ser Pro Ala Leu Ser Thr Trp Gly Asp Pro Val Leu Leu Lys Thr Glu
                165                 170                 175     
Val Gln Leu Thr Ala Ser Glu Glu Ala Glu Cys His Trp Ala Asp Thr
            180                 185                 190         
Glu Leu Asn Arg Arg Arg Lys Leu Phe Cys Ser Lys Val Glu Gly Tyr
        195                 200                 205             
Gly Ser Ile Cys Ser Cys Lys Asp Pro Ala Pro Ile Glu Phe Asn Pro
    210                 215                 220                 
Asp Pro Leu Ser Asn Asn Asn Val Tyr Asn Ile Pro Val Ala Val Ile
225                 230                 235                 240 
Ala Gly Asn Arg Pro Asn Tyr Leu Tyr Arg Met Leu Arg Ser Leu Leu
                245                 250                 255     
Ser Ser His Gly Val Asn Pro Gln Met Ile Thr Val Phe Ile Asp Gly
            260                 265                 270         
Tyr Tyr Glu Glu Pro Met Asp Val Val Asp Leu Phe Gly Leu Lys Gly
        275                 280                 285             
Val Gln His Thr Pro Ile Ser Ile Lys Asn Ala Arg Val Ser Gln His
    290                 295                 300                 
Tyr Lys Ala Ser Leu Thr Ala Thr Phe Asn Leu His Pro Asp Ala Asp
305                 310                 315                 320 
Phe Ala Ile Val Leu Glu Glu Asp Leu Asp Ile Ser Ile Asp Phe Phe
                325                 330                 335     
Ser Phe Leu Gly Gln Thr Ile His Leu Leu His Glu Asp Asp Ser Leu
            340                 345                 350         
Tyr Cys Ile Ser Ala Trp Asn Asp Gln Gly Tyr Glu His Thr Ala Glu
        355                 360                 365             
Asp Pro Ser Leu Leu Tyr Arg Val Glu Ser Met Pro Gly Leu Gly Trp
    370                 375                 380                 
Val Leu Lys Lys Ser Leu Tyr Lys Asp Glu Leu Glu Pro Lys Trp Pro
385                 390                 395                 400 
Thr Pro Glu Lys Leu Trp Asp Trp Asp Met Trp Met Arg Met Pro Glu
                405                 410                 415     
Gln Arg Lys Gly Arg Glu Cys Val Ile Pro Asp Val Ser Arg Ser Tyr
            420                 425                 430         
His Phe Gly Ile Ile Gly Leu Asn Met Asn Gly Tyr Phe His Glu Val
        435                 440                 445             
Tyr Phe Lys Lys His Lys Phe Asn Thr Ile Pro Asn Val Gln Met Lys
    450                 455                 460                 
Asn Val Glu Asn Leu Lys Lys Asp Pro Tyr Glu Ile Glu Ile Gln Asn
465                 470                 475                 480 
Leu Leu Arg Glu Ala Glu Val Leu Asp His Ser Lys Asn Pro Cys Glu
                485                 490                 495     
Asp Ser Phe Ile Pro Asp Thr Glu Gly Lys Thr Phe Val Met Phe Ile
            500                 505                 510         
Lys Met Glu Gln Glu Thr Asp Thr Asn Thr Trp Thr Glu Leu Ala Lys
        515                 520                 525             
Cys Leu His Val Trp Asp Leu Asp Val Arg Gly Tyr His Gly Leu Trp
    530                 535                 540                 
Arg Leu Phe Arg Lys Lys Asn His Ile Leu Val Val Ala Phe Pro Ile
545                 550                 555                 560 
Ser Pro Tyr Ser Val Lys Lys Pro Ser Asn Val Thr Pro Ile His Leu
                565                 570                 575     
Glu Pro Ala Pro Lys Glu Glu Gly Pro Pro Val Glu Gln Met
            580                 585                 590 


<210> 117
<211> 1789
<212> DNA
<213> Xenopus

<400> 117
cgcgccgtta acgaagaaga gatcgaccaa gactacgacg aatccttgca acaagctgac 60
tctccaagaa gaccagctaa ctccaagaag gttttggaca ctgagatcta ctcttccaga 120
tccaaggttt acattgctgt tgacggtact actgttttgg aggacgaggt tcacgaacaa 180
ggtagaggta tccacgttat cgttttgaac caggctactg gtcatgttat ggctaagaga 240
gttttcgaca cttactctcc acacgaagat gaggctatgg ttttgttctt gaacatggtt 300
gctagaggta gaatcttgat cttcactatc aaggacgagg gatcctttca cttgaaggac 360
actgctaaga acttgttgaa gtccttgggt tcccaaattg ctccatcctt gggatggaga 420
gacatgtgga ctttcgttgt taagaagggt ggacaggttt acggtgaaaa gcactctaag 480
tccccagctt tgtctacttg gggtgaccca atcttgttga aaactgacat ccagttggtt 540
ccaccagagg atgctgaatg tcactggcca gacactgagt tgaacagaag aagaaagaga 600
ttctgttcca aggttgaggg ttacggttct gtttgttcct gtaaggaccc aactccaatc 660
gaattcaacc caatgccatt gaaagagaac aaggttacaa ctgttccagt tgctgttatc 720
gctggtaaca gaccaaacta cttgtacaga atgttgagat ccttgttgtc cgctcaggga 780
gtttctccac agatgatcac tgttttcatc gacggttact acgaagaacc aatggacgtt 840
gttgagttgt acggattgaa gggtattcag cacactccaa tctccatcaa gaacgctaga 900
gtttcccaac actacaaggc ttccttgact gctactttca acttgcaccc agacgctaag 960
ttcgctatcg ttttggaaga ggacttggac atttccgttg atttcttctc cttcttgtcc 1020
cagactatcc acttgttgga agaggatgag tccttgtact gtatctctgc ttggaacgac 1080
caaggttacg aacacactgc tgaggattct tccttgttgt acagagttga gtccatgcca 1140
ggattgggat gggttttgag aaagaacttg tacaaggacg agttggaacc aaaatggcca 1200
actccagaga agttgtggga ttgggacatg tggatgagaa tgccagagca gagaaaggac 1260
agagagtgtt tgattccaga cgtttccaga tcttaccact tcggtattgt tggattgaac 1320
atgaacggtt acttccacga ggcttacttc aagaagcaca agttcaacac tgttccaaac 1380
gttcagttgt ccaacgttaa gtccttgcag aaggacgctt acgagattga gatccacaga 1440
atcttgtctg aggctgaggt tttggaccat tccaagaacc catgtgagga ttccttcatc 1500
ccagacacag agggaaagac ttacatcatg tacatcaaga tggaacaaga ggctgacttc 1560
actacttgga ctcagttggc taagtgtttg cacatttggg acttggatgt tagaggtaac 1620
cacaagggtt tgtggagatt gttcagaaag aagaaccact tcttggttgt tggtttccca 1680
ttctccccat acgctgttaa gaagccagct tccgttactc caatctactt ggagccacca 1740
ccaaaagaag aagctgctgt tgctggtatt gaccagtcct agtagttaa             1789

<210> 118
<211> 592
<212> PRT
<213> Xenopus

<400> 118
Arg Ala Val Asn Glu Glu Glu Ile Asp Gln Asp Tyr Asp Glu Ser Leu
 1               5                  10                  15      
Gln Gln Ala Asp Ser Pro Arg Arg Pro Ala Asn Ser Lys Lys Val Leu
            20                  25                  30          
Asp Thr Glu Ile Tyr Ser Ser Arg Ser Lys Val Tyr Ile Ala Val Asp
        35                  40                  45              
Gly Thr Thr Val Leu Glu Asp Glu Val His Glu Gln Gly Arg Gly Ile
    50                  55                  60                  
His Val Ile Val Leu Asn Gln Ala Thr Gly His Val Met Ala Lys Arg
65                  70                  75                  80  
Val Phe Asp Thr Tyr Ser Pro His Glu Asp Glu Ala Met Val Leu Phe
                85                  90                  95      
Leu Asn Met Val Ala Arg Gly Arg Ile Leu Ile Phe Thr Ile Lys Asp
            100                 105                 110         
Glu Gly Ser Phe His Leu Lys Asp Thr Ala Lys Asn Leu Leu Lys Ser
        115                 120                 125             
Leu Gly Ser Gln Ile Ala Pro Ser Leu Gly Trp Arg Asp Met Trp Thr
    130                 135                 140                 
Phe Val Val Lys Lys Gly Gly Gln Val Tyr Gly Glu Lys His Ser Lys
145                 150                 155                 160 
Ser Pro Ala Leu Ser Thr Trp Gly Asp Pro Ile Leu Leu Lys Thr Asp
                165                 170                 175     
Ile Gln Leu Val Pro Pro Glu Asp Ala Glu Cys His Trp Pro Asp Thr
            180                 185                 190         
Glu Leu Asn Arg Arg Arg Lys Arg Phe Cys Ser Lys Val Glu Gly Tyr
        195                 200                 205             
Gly Ser Val Cys Ser Cys Lys Asp Pro Thr Pro Ile Glu Phe Asn Pro
    210                 215                 220                 
Met Pro Leu Lys Glu Asn Lys Val Thr Thr Val Pro Val Ala Val Ile
225                 230                 235                 240 
Ala Gly Asn Arg Pro Asn Tyr Leu Tyr Arg Met Leu Arg Ser Leu Leu
                245                 250                 255     
Ser Ala Gln Gly Val Ser Pro Gln Met Ile Thr Val Phe Ile Asp Gly
            260                 265                 270         
Tyr Tyr Glu Glu Pro Met Asp Val Val Glu Leu Tyr Gly Leu Lys Gly
        275                 280                 285             
Ile Gln His Thr Pro Ile Ser Ile Lys Asn Ala Arg Val Ser Gln His
    290                 295                 300                 
Tyr Lys Ala Ser Leu Thr Ala Thr Phe Asn Leu His Pro Asp Ala Lys
305                 310                 315                 320 
Phe Ala Ile Val Leu Glu Glu Asp Leu Asp Ile Ser Val Asp Phe Phe
                325                 330                 335     
Ser Phe Leu Ser Gln Thr Ile His Leu Leu Glu Glu Asp Glu Ser Leu
            340                 345                 350         
Tyr Cys Ile Ser Ala Trp Asn Asp Gln Gly Tyr Glu His Thr Ala Glu
        355                 360                 365             
Asp Ser Ser Leu Leu Tyr Arg Val Glu Ser Met Pro Gly Leu Gly Trp
    370                 375                 380                 
Val Leu Arg Lys Asn Leu Tyr Lys Asp Glu Leu Glu Pro Lys Trp Pro
385                 390                 395                 400 
Thr Pro Glu Lys Leu Trp Asp Trp Asp Met Trp Met Arg Met Pro Glu
                405                 410                 415     
Gln Arg Lys Asp Arg Glu Cys Leu Ile Pro Asp Val Ser Arg Ser Tyr
            420                 425                 430         
His Phe Gly Ile Val Gly Leu Asn Met Asn Gly Tyr Phe His Glu Ala
        435                 440                 445             
Tyr Phe Lys Lys His Lys Phe Asn Thr Val Pro Asn Val Gln Leu Ser
    450                 455                 460                 
Asn Val Lys Ser Leu Gln Lys Asp Ala Tyr Glu Ile Glu Ile His Arg
465                 470                 475                 480 
Ile Leu Ser Glu Ala Glu Val Leu Asp His Lys Asn Pro Cys Glu Asp
                485                 490                 495     
Ser Phe Ile Pro Asp Thr Glu Gly Lys Thr Tyr Ile Met Tyr Ile Lys
            500                 505                 510         
Met Glu Gln Glu Ala Asp Phe Thr Thr Trp Thr Gln Leu Ala Lys Cys
        515                 520                 525             
Leu His Ile Trp Asp Leu Asp Val Arg Gly Asn His Lys Gly Leu Trp
    530                 535                 540                 
Arg Leu Phe Arg Lys Lys Asn His Phe Leu Val Val Gly Phe Pro Phe
545                 550                 555                 560 
Ser Pro Tyr Ala Val Lys Lys Pro Ala Ser Val Thr Pro Ile Tyr Leu
                565                 570                 575     
Glu Pro Pro Pro Lys Glu Glu Ala Ala Val Ala Gly Ile Asp Gln Ser
            580                 585                 590         


<210> 119
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PpHIS3 1

<400> 119
gagctcggcc acggtggccc tgtgagtctg gct                              33

<210> 120
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PpHIS3 2

<400> 120
ggccggcctc agaaaagaac acccttcgta ct                               32

<210> 121
<211> 614
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpHIS3 ORF (the 5' arm)

<400> 121
gagctcggcc acggtggccc tgtgagtctg gctcaatcac ttttcaaaga taaggactat 60
tctgcagaac atgcagccca ggcaacatca tcccagttca tctctgtgaa cacaggaata 120
ggattcctgg accatatgtt acacgcactt gctaagcacg gcggctggtc tgtcattatc 180
gaatgtgtag gtgatttgca cattgatgac catcattcag cagaagatac tggaatcgca 240
ttggggatgg cattcaaaga agccttgggc catgttcgtg gtatcaaaag attcgggtcc 300
ggatttgctc cactagacga agctctcagt cgggctgtta ttgatatgtc taacaggccc 360
tatgctgttg tcgatctggg tttgaaaaga gagaagattg gagacctatc gtgtgagatg 420
attccccatg ttttggaaag ttttgcccaa ggagcccatg taaccatgca cgtagattgt 480
ttgcgaggtt tcaacgacca tcatcgtgcc gagagtgcat tcaaagcttt ggctatagct 540
atcaaagagg ccatttcaag caacggcacg gacgacattc caagtacgaa gggtgttctt 600
ttctgaggcc ggcc                                                   614

<210> 122
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer PpHIS3 3

<400> 122
atttaaatgt ctggaaggtg tctacatctg tga                              33

<210> 123
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer PpHIS3 4

<400> 123
gtcgacggcc agtctggcca agtaatcatt gtct                             34

<210> 124
<211> 1067
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpHIS3 ORF (the 3' arm)

<400> 124
atttaaatgt ctggaaggtg tctacatctg tgaaatccgt atttatttaa gtaaaacaat 60
cagtaatata agatcttagt tggtttacca catagtcggt accggtcgtg tgaacaatag 120
ttcaatgcct ccgattgtgc cttattgttg tggtctgcat tttcgcggcg aaatttctac 180
ttcagatcgg ggctgagatg accttagtac tcacatcaac cagctcgttg aaagttccca 240
catgaccact caatgtttaa tagcttggca cccatgaggt tgaagaaact acttaaggtg 300
ttttgtgcct cagtagtgct gttagcggcg acatctgtgg tgttattttt ccactttgga 360
ggtcagatca taatccccat accggaacgc actgtgacct taagtactcc tcccgcaaac 420
gatacttggc agtttcaaca gttcttcaac ggctatttag acgccctgtt agagaataac 480
ctgtcgtatc cgataccaga aaggtggaat catgaagtta caaatgtaag attcttcaat 540
cgcataggtg aattgctctc ggagagtagg ctacaggagc tgattcattt tagtcctgag 600
ttcatagagg ataccagtga caaattcgac aatattgttg aacaaattcc agcaaaatgg 660
ccttacgaaa acatgtacag aggagatgga tacgttattg ttggtggtgg cagacacacc 720
tttttggcac tgctgaatat caacgctttg agaagagcag gcaataaact gccagttgag 780
gtcgtgttgc caacttacga cgactatgag gaagatttct gtgaaaatca ttttccactt 840
ttgaatgcaa gatgcgtaat cttagaagaa cgatttggtg accaagttta tccccggtta 900
caactaggag gctaccagtt taaaatattt gcgatagcag caagttcatt caaaaactgc 960
tttttgttag attcagataa tatacccttg cgaaagatgg ataagatatt ctcaagcgaa 1020
ctatacaaga ataagacaat gattacttgg ccagactggc cgtcgac               1067

<210> 125
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PpALG3TT-f

<400> 125
ggccggccat ttacaattag taatattaag gt                               32

<210> 126
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PpALG3TT-rev

<400> 126
gtttaaacct actaagcgac gaaaacggga                                  30

<210> 127
<211> 392
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpALG3 transcription terminator

<400> 127
ggccggccat ttacaattag taatattaag gtggtaaaaa cattcgtaga attgaaatga 60
attaatatag tatgacaatg gttcatgtct ataaatctcc ggcttcggta ccttctcccc 120
aattgaatac attgtcaaaa tgaatggttg aactattagg ttcgccagtt tcgttattaa 180
gaaaactgtt aaaatcaaat tccatatcat cggttccagt gggaggacca gttccatcgc 240
caaaatcctg taagaatcca ttgtcagaac ctgtaaagtc agtttgagat gaaatttttc 300
cggtctttgt tgacttggaa gcttcgttaa ggttaggtga aacagtttga tcaaccagcg 360
gctcccgttt tcgtcgctta gtaggtttaa ac                               392

<210> 128
<211> 506
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpGAP promoter

<400> 128
ctcgagagat cttttttgta gaaatgtctt ggtgtcctcg tccaatcagg tagccatctc 60
tgaaatatct ggctccgttg caactccgaa cgacctgctg gcaacgtaaa attctccggg 120
gtaaaactta aatgtggagt aatggaacca gaaacgtctc ttcccttctc tctccttcca 180
ccgcccgtta ccgtccctag gaaattttac tctgctggag agcttcttct acggccccct 240
tgcagcaatg ctcttcccag cattacgttg cgggtaaaac ggaggtcgtg tacccgacct 300
agcagcccag ggatggaaaa gtcccggccg tcgctggcaa taatagcggg cggacgcatg 360
tcatgagatt attggaaacc accagaatcg aatataaaag gcgaacacct ttcccaattt 420
tggtttctcc tgacccaaag actttaaatt taatttattt gtccctattt caatcaattg 480
aacaactatc aaaacacagc ggccgc                                      506

<210> 129
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> ScCYC transcription terminator

<400> 129
ttaattaaac aggccccttt tcctttgtcg atatcatgta attagttatg tcacgcttac 60
attcacgccc tcctcccaca tccgctctaa ccgaaaagga aggagttaga caacctgaag 120
tctaggtccc tatttatttt ttttaatagt tatgttagta ttaagaacgt tatttatatt 180
tcaaattttt cttttttttc tgtacaaacg cgtgtacgca tgtaacatta tactgaaaac 240
cttgcttgag aaggttttgg gacgctcgaa ggctttaatt tgcaagctgc cggctcttaa 300


<210> 130
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> PpAOX1 promoter

<400> 130
ctcgagagat ctaacatcca aagacgaaag gttgaatgaa acctttttgc catccgacat 60
ccacaggtcc attctcacac ataagtgcca aacgcaacag gaggggatac actagcagca 120
gaccgttgca aacgcaggac ctccactcct cttctcctca acacccactt ttgccatcga 180
aaaaccagcc cagttattgg gcttgattgg agctcgctca ttccaattcc ttctattagg 240
ctactaacac catgacttta ttagcctgtc tatcctggcc cccctggcga ggttcatgtt 300
tgtttatttc cgaatgcaac aagctccgca ttacacccga acatcactcc agatgagggc 360
tttctgagtg tggggtcaaa tagtttcatg ttccccaaat ggcccaaaac tgacagttta 420
aacgctgtct tggaacctaa tatgacaaaa gcgtgatctc atccaagatg aactaagttt 480
ggttcgttga aatgctaacg gccagttggt caaaaagaaa cttccaaaag tcggcatacc 540
gtttgtcttg tttggtattg attgacgaat gctcaaaaat aatctcatta atgcttagcg 600
cagtctctct atcgcttctg aaccccggtg cacctgtgcc gaaacgcaaa tggggaaaca 660
cccgcttttt ggatgattat gcattgtctc cacattgtat gcttccaaga ttctggtggg 720
aatactgctg atagcctaac gttcatgatc aaaatttaac tgttctaacc cctacttgac 780
agcaatatat aaacagaagg aagctgccct gtcttaaacc ttttttttta tcatcattat 840
tagcttactt tcataattgc gactggttcc aattgacaag cttttgattt taacgacttt 900
taacgacaac ttgagaagat caaaaaacaa ctaattattc gaaacggcgg ccgc       954

<210> 131
<211> 1415
<212> DNA
<213> Artificial Sequence

<220> 
<223> TNFR-IgG1

<400> 131
cagctgccag ctcaagttgc ttttactcca tacgctccag aaccaggttc tacttgtaga 60
ttgagagagt actacgacca aactgctcag atgtgttgtt ccaagtgttc tccaggtcaa 120
cacgctaagg ttttctgtac taagacttcc gacactgttt gtgactcttg tgaggactcc 180
acttacactc aattgtggaa ctgggttcca gaatgtttgt cctgtggttc cagatgttct 240
tccgaccaag ttgagactca ggcttgtact agagagcaga acagaatctg tacttgtaga 300
cctggttggt actgtgcttt gtccaagcaa gagggttgta gattgtgtgc tccattgaga 360
aagtgtagac caggtttcgg tgttgctaga ccaggtacag aaacttccga cgttgtttgt 420
aagccatgtg ctccaggaac tttctccaac actacttcct ccactgacat ctgtagacca 480
caccaaatct gtaacgttgt tgctatccca ggtaacgctt ctatggacgc tgtttgtact 540
tctacttccc caactagatc catggctcca ggtgctgttc atttgccaca gccagtttcc 600
actagatccc aacacactca accaactcca gaaccatcta ctgctccatc cacttccttt 660
ttgttgccaa tgggaccatc tccacctgct gaaggttcta ctggtgacga accaaagtcc 720
tgtgacaaga ctcatacttg tccaccatgt ccagctccag aattgttggg tggtccatcc 780
gtttttttgt tcccaccaaa gccaaaggac actttgatga tctccagaac tccagaggtt 840
acatgtgttg ttgttgacgt ttctcacgag gacccagagg ttaagttcaa ctggtacgtt 900
gacggtgttg aagttcacaa cgctaagact aagccaagag aagagcagta caactccaca 960
tacagagttg tttccgtttt gactgttttg caccaggatt ggttgaacgg aaaggactac 1020
aagtgtaagg tttccaacaa ggctttgcca gctccaatgc aaaagactat ctccaaggct 1080
aagggtcaac caagagagcc acaggtttac actttgccac catccagaga tgagttgact 1140
aagaatcagg tttccttgac ttgtttggtt aagggattct acccaagaca catcgctgtt 1200
gaatgggaat ctaacggaca gccagagaac aactacaaga ctactccacc agttttggac 1260
tctgacggtt ccttcttctt gtactccaag ttgactgttg acaagtccag atggcaacag 1320
ggtaacgttt tctcctgttc cgttatgcat gaggctttgc acaaccacta cactcaaaag 1380
tccttgtctt tgtcccctgg taagtagggc cggcc                            1415

<210> 132
<211> 1415
<212> DNA
<213> Artificial Sequence

<220> 
<223> TNFR-Fc

<400> 132
cagctgccag ctcaagttgc ttttactcca tacgctccag aaccaggttc tacttgtaga 60
ttgagagagt actacgacca aactgctcag atgtgttgtt ccaagtgttc tccaggtcaa 120
cacgctaagg ttttctgtac taagacttcc gacactgttt gtgactcttg tgaggactcc 180
acttacactc aattgtggaa ctgggttcca gaatgtttgt cctgtggttc cagatgttct 240
tccgaccaag ttgagactca ggcttgtact agagagcaga acagaatctg tacttgtaga 300
cctggttggt actgtgcttt gtccaagcaa gagggttgta gattgtgtgc tccattgaga 360
aagtgtagac caggtttcgg tgttgctaga ccaggtacag aaacttccga cgttgtttgt 420
aagccatgtg ctccaggaac tttctccaac actacttcct ccactgacat ctgtagacca 480
caccaaatct gtaacgttgt tgctatccca ggtaacgctt ctatggacgc tgtttgtact 540
tctacttccc caactagatc catggctcca ggtgctgttc atttgccaca gccagtttcc 600
actagatccc aacacactca accaactcca gaaccatcta ctgctccatc cacttccttt 660
ttgttgccaa tgggaccatc tccacctgct gaaggttcta ctggtgacga gccaaagtcc 720
tgtgacaaga cacatacttg tccaccatgt ccagctccag aattgttggg tggtccatcc 780
gttttcttgt tcccaccaaa gccaaaggac actttgatga tctccagaac tccagaggtt 840
acatgtgttg ttgttgacgt ttctcacgag gacccagagg ttaagttcaa ctggtacgtt 900
gacggtgttg aagttcacaa cgctaagact aagccaagag aagagcagta caactccact 960
tacagagttg tttccgtttt gactgttttg caccaggatt ggttgaacgg taaagaatac 1020
aagtgtaagg tttccaacaa ggctttgcca gctccaatcg aaaagacaat ctccaaggct 1080
aagggtcaac caagagagcc acaggtttac actttgccac catccagaga agagatgact 1140
aagaaccagg tttccttgac ttgtttggtt aaaggattct acccatccga cattgctgtt 1200
gaatgggaat ctaacggtca accagagaac aactacaaga ctactccacc agttttggat 1260
tctgacggtt ccttcttctt gtactccaag ttgactgttg acaagtccag atggcaacag 1320
ggtaacgttt tctcctgttc cgttatgcat gaggctttgc acaaccacta cactcaaaag 1380
tccttgtctt tgtccccagg taagtagggc cggcc                            1415

<210> 133
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 133
gggtacccag ctgccagctc aagttgcttt tactccatac                       40

<210> 134
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 134
gtgtcttgtc acaggacttt ggctcgtcac cagtagaacc ttcagcaggt ggagatg    57

<210> 135
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 135
catctccacc tgctgaaggt tctactggtg acgagccaaa gtcctgtgac aagacac    57

<210> 136
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 136
ggagctcggc cggccctact tacctgggga caaagacaag gacttttg              48

<210> 137
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> HSA pre-signal sequence

<400> 137
gaattcgaaa cgatgaagtg ggttaccttt atctctttgt tgtttctttt ctcttctgct 60
tactct                                                            66

<210> 138
<211> 1478
<212> DNA
<213> Artificial Sequence

<220> 
<223> HSAss-TNFR-Fc

<400> 138
gaattcgaaa cgatgaagtg ggttaccttt atctctttgt tgtttctttt ctcttctgct 60
tactctctgc cagctcaagt tgcttttact ccatacgctc cagaaccagg ttctacttgt 120
agattgagag agtactacga ccaaactgct cagatgtgtt gttccaagtg ttctccaggt 180
caacacgcta aggttttctg tactaagact tccgacactg tttgtgactc ttgtgaggac 240
tccacttaca ctcaattgtg gaactgggtt ccagaatgtt tgtcctgtgg ttccagatgt 300
tcttccgacc aagttgagac tcaggcttgt actagagagc agaacagaat ctgtacttgt 360
agacctggtt ggtactgtgc tttgtccaag caagagggtt gtagattgtg tgctccattg 420
agaaagtgta gaccaggttt cggtgttgct agaccaggta cagaaacttc cgacgttgtt 480
tgtaagccat gtgctccagg aactttctcc aacactactt cctccactga catctgtaga 540
ccacaccaaa tctgtaacgt tgttgctatc ccaggtaacg cttctatgga cgctgtttgt 600
acttctactt ccccaactag atccatggct ccaggtgctg ttcatttgcc acagccagtt 660
tccactagat cccaacacac tcaaccaact ccagaaccat ctactgctcc atccacttcc 720
tttttgttgc caatgggacc atctccacct gctgaaggtt ctactggtga cgagccaaag 780
tcctgtgaca agacacatac ttgtccacca tgtccagctc cagaattgtt gggtggtcca 840
tccgttttct tgttcccacc aaagccaaag gacactttga tgatctccag aactccagag 900
gttacatgtg ttgttgttga cgtttctcac gaggacccag aggttaagtt caactggtac 960
gttgacggtg ttgaagttca caacgctaag actaagccaa gagaagagca gtacaactcc 1020
acttacagag ttgtttccgt tttgactgtt ttgcaccagg attggttgaa cggtaaagaa 1080
tacaagtgta aggtttccaa caaggctttg ccagctccaa tcgaaaagac aatctccaag 1140
gctaagggtc aaccaagaga gccacaggtt tacactttgc caccatccag agaagagatg 1200
actaagaacc aggtttcctt gacttgtttg gttaaaggat tctacccatc cgacattgct 1260
gttgaatggg aatctaacgg tcaaccagag aacaactaca agactactcc accagttttg 1320
gattctgacg gttccttctt cttgtactcc aagttgactg ttgacaagtc cagatggcaa 1380
cagggtaacg ttttctcctg ttccgttatg catgaggctt tgcacaacca ctacactcaa 1440
aagtccttgt ctttgtcccc aggtaagtag ggccggcc                         1478

<210> 139
<211> 485
<212> PRT
<213> Artificial Sequence

<220> 
<223> HSAss-TNFR-Fc peptide

<400> 139
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala
 1               5                  10                  15      
Tyr Ser Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro
            20                  25                  30          
Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met
        35                  40                  45              
Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr
    50                  55                  60                  
Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr
65                  70                  75                  80  
Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys
                85                  90                  95      
Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg
            100                 105                 110         
Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu
        115                 120                 125             
Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly
    130                 135                 140                 
Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys
145                 150                 155                 160 
Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg
                165                 170                 175     
Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met
            180                 185                 190         
Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly
        195                 200                 205             
Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln
    210                 215                 220                 
Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro
225                 230                 235                 240 
Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Glu Pro Lys
                245                 250                 255     
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
            260                 265                 270         
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
        275                 280                 285             
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
    290                 295                 300                 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
305                 310                 315                 320 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
                325                 330                 335     
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            340                 345                 350         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
        355                 360                 365             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    370                 375                 380                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
385                 390                 395                 400 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                405                 410                 415     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            420                 425                 430         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
        435                 440                 445             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
    450                 455                 460                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
465                 470                 475                 480 
Leu Ser Pro Gly Lys
                485 


<210> 140
<211> 467
<212> PRT
<213> Artificial Sequence

<220> 
<223> Secreted TNFR-Fc peptide

<400> 140
Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser
 1               5                  10                  15      
Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys
            20                  25                  30          
Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr
        35                  40                  45              
Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu
    50                  55                  60                  
Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser
65                  70                  75                  80  
Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys
                85                  90                  95      
Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys
            100                 105                 110         
Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala
        115                 120                 125             
Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro
    130                 135                 140                 
Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His
145                 150                 155                 160 
Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala
                165                 170                 175     
Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val
            180                 185                 190         
His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr
        195                 200                 205             
Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly
    210                 215                 220                 
Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Glu Pro Lys Ser Cys
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    450                 455                 460                 
Pro Gly Lys
465         


<210> 141
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 141
gggagagttg aaggttgtat tattgcc                                     27

<210> 142
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 142
ctactaagcg acgaaaacgg gagccg                                      26

<210> 143
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 143
gttccctcat taagaggatc acaaacg                                     27

<210> 144
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 144
gataatagtg cgggctggta cttcg                                       25
