                         SEQUENCE LISTING

<110>  Servicio Andaluz de Salud
<110>  Universidad de Granada
<110>  Consejo Superior de Investigaciones Cientficas (CSIC)
 
<120>  Mtodo de obtencin de datos tiles para  evaluar, predecir y/o
       pronosticar la respuesta al tratamiento con anlogos de pirimidina

<130>  PCT-05237

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


<210>  2
<211>  2930
<212>  DNA
<213>  Homo sapiens

<400>  2
agcagacgag ggcttgtgcg agagggggcc gggcggctgc agggaaggcg gagtccaagg       60

ggaaaacgaa actgagaacc agctctcccg aagccgcggg tctccggccg gcggcggcgg      120

cggcggcggc ggcggcgcag tttgctcata ctttgtgact tgcggtcaca gtggcattca      180

gctccacact tggtagaacc acaggcacga caagcataga aacatcctaa acaatcttca      240

tcgaggcatc gaggtccatc ccaataaaaa tcaggagacc ctggctatca tagaccttag      300

tcttcgctgg tatcactcgt ctgtctgaac cagcggttgc atttttttaa gccttctttt      360

ttctctttta ccagtttctg gagcaaattc agtttgcctt cctggatttg taaattgtaa      420

tgacctcaaa actttagcag ttcttccatc tgactcaggt ttgcttctct ggcggtcttc      480

agaatcaaca tccacacttc cgtgattatc tgcgtgcatt ttggacaaag cttccaacca      540

ggatacggga agaagaaatg gctggtgatc tttcagcagg tttcttcatg gaggaactta      600

atacataccg tcagaagcag ggagtagtac ttaaatatca agaactgcct aattcaggac      660

ctccacatga taggaggttt acatttcaag ttataataga tggaagagaa tttccagaag      720

gtgaaggtag atcaaagaag gaagcaaaaa atgccgcagc caaattagct gttgagatac      780

ttaataagga aaagaaggca gttagtcctt tattattgac aacaacgaat tcttcagaag      840

gattatccat ggggaattac ataggcctta tcaatagaat tgcccagaag aaaagactaa      900

ctgtaaatta tgaacagtgt gcatcggggg tgcatgggcc agaaggattt cattataaat      960

gcaaaatggg acagaaagaa tatagtattg gtacaggttc tactaaacag gaagcaaaac     1020

aattggccgc taaacttgca tatcttcaga tattatcaga agaaacctca gtgaaatctg     1080

actacctgtc ctctggttct tttgctacta cgtgtgagtc ccaaagcaac tctttagtga     1140

ccagcacact cgcttctgaa tcatcatctg aaggtgactt ctcagcagat acatcagaga     1200

taaattctaa cagtgacagt ttaaacagtt cttcgttgct tatgaatggt ctcagaaata     1260

atcaaaggaa ggcaaaaaga tctttggcac ccagatttga ccttcctgac atgaaagaaa     1320

caaagtatac tgtggacaag aggtttggca tggattttaa agaaatagaa ttaattggct     1380

caggtggatt tggccaagtt ttcaaagcaa aacacagaat tgacggaaag acttacgtta     1440

ttaaacgtgt taaatataat aacgagaagg cggagcgtga agtaaaagca ttggcaaaac     1500

ttgatcatgt aaatattgtt cactacaatg gctgttggga tggatttgat tatgatcctg     1560

agaccagtga tgattctctt gagagcagtg attatgatcc tgagaacagc aaaaatagtt     1620

caaggtcaaa gactaagtgc cttttcatcc aaatggaatt ctgtgataaa gggaccttgg     1680

aacaatggat tgaaaaaaga agaggcgaga aactagacaa agttttggct ttggaactct     1740

ttgaacaaat aacaaaaggg gtggattata tacattcaaa aaaattaatt catagagatc     1800

ttaagccaag taatatattc ttagtagata caaaacaagt aaagattgga gactttggac     1860

ttgtaacatc tctgaaaaat gatggaaagc gaacaaggag taagggaact ttgcgataca     1920

tgagcccaga acagatttct tcgcaagact atggaaagga agtggacctc tacgctttgg     1980

ggctaattct tgctgaactt cttcatgtat gtgacactgc ttttgaaaca tcaaagtttt     2040

tcacagacct acgggatggc atcatctcag atatatttga taaaaaagaa aaaactcttc     2100

tacagaaatt actctcaaag aaacctgagg atcgacctaa cacatctgaa atactaagga     2160

ccttgactgt gtggaagaaa agcccagaga aaaatgaacg acacacatgt tagagccctt     2220

ctgaaaaagt atcctgcttc tgatatgcag ttttccttaa attatctaaa atctgctagg     2280

gaatatcaat agatatttac cttttatttt aatgtttcct ttaatttttt actattttta     2340

ctaatctttc tgcagaaaca gaaaggtttt cttctttttg cttcaaaaac attcttacat     2400

tttacttttt cctggctcat ctctttattc tttttttttt tttaaagaca gagtctcgct     2460

ctgttgccca ggctggagtg caatgacaca gtcttggctc actgcaactt ctgcctcttg     2520

ggttcaagtg attctcctgc ctcagcctcc tgagtagctg gattacaggc atgtgccacc     2580

cacccaacta atttttgtgt ttttaataaa gacagggttt caccatgttg gccaggctgg     2640

tctcaaactc ctgacctcaa gtaatccacc tgcctcggcc tcccaaagtg ctgggattac     2700

agggatgagc caccgcgccc agcctcatct ctttgttcta aagatggaaa aaccaccccc     2760

aaattttctt tttatactat taatgaatca atcaattcat atctatttat taaatttcta     2820

ccgcttttag gccaaaaaaa tgtaagatcg ttctctgcct cacatagctt acaagccagc     2880

tggagaaata tggtactcat taaaaaaaaa aaaaaaagtg atgtacaacc                2930


<210>  3
<211>  24
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  cebador PKR Carboxi-terminal (F)

<400>  3
gaaggcggag cgtgaagtaa aagc                                              24


<210>  4
<211>  24
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador PKR Carboxi-terminal (R)

<400>  4
cttccacaca gtcaaggtcc ttag                                              24


<210>  5
<211>  20
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador PKR Dominio regulador (F)

<400>  5
gacctccaca tgataggagg                                                   20


<210>  6
<211>  21
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador PKR Dominio regulador (R)

<400>  6
ccatggataa tccttctgaa g                                                 21


<210>  7
<211>  24
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador PKR Dominio kinasa (F)

<400>  7
gaaggcggag cgtgaagtaa aagc                                              24


<210>  8
<211>  20
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador PKR Dominio kinasa (R)

<400>  8
ggatcataat cactgctctc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador PKR Dominio cataltico (F)

<400>  9
cttcttcatg tatgtgacac                                                   20


<210>  10
<211>  24
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  Cebador PKR Dominio cataltico (R)

<400>  10
cttccacaca gtcaaggtcc ttag                                              24


