                         LISTA DE SECUENCIAS

<110>  Universidad de Santiago de Compostela
 
<120>  Uso de inhibidores de p53 para reducir la ingesta y para reducir 
       el peso corporal

<130>  p53

<150>  ES201130250
<151>  2011-02-25

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  2586
<212>  RNA
<213>  Homo sapiens

<400>  1
gauugggguu uuccccuccc augugcucaa gacuggcgcu aaaaguuuug agcuucucaa       60

aagucuagag ccaccgucca gggagcaggu agcugcuggg cuccggggac acuuugcguu      120

cgggcuggga gcgugcuuuc cacgacggug acacgcuucc cuggauuggc agccagacug      180

ccuuccgggu cacugccaug gaggagccgc agucagaucc uagcgucgag cccccucuga      240

gucaggaaac auuuucagac cuauggaaac uacuuccuga aaacaacguu cugucccccu      300

ugccguccca agcaauggau gauuugaugc uguccccgga cgauauugaa caaugguuca      360

cugaagaccc agguccagau gaagcuccca gaaugccaga ggcugcuccc cccguggccc      420

cugcaccagc agcuccuaca ccggcggccc cugcaccagc ccccuccugg ccccugucau      480

cuucuguccc uucccagaaa accuaccagg gcagcuacgg uuuccgucug ggcuucuugc      540

auucugggac agccaagucu gugacuugca cguacucccc ugcccucaac aagauguuuu      600

gccaacuggc caagaccugc ccugugcagc uguggguuga uuccacaccc ccgcccggca      660

cccgcguccg cgccauggcc aucuacaagc agucacagca caugacggag guugugaggc      720

gcugccccca ccaugagcgc ugcucagaua gcgauggucu ggccccuccu cagcaucuua      780

uccgagugga aggaaauuug cguguggagu auuuggauga cagaaacacu uuucgacaua      840

gugugguggu gcccuaugag ccgccugagg uuggcucuga cuguaccacc auccacuaca      900

acuacaugug uaacaguucc ugcaugggcg gcaugaaccg gaggcccauc cucaccauca      960

ucacacugga agacuccagu gguaaucuac ugggacggaa cagcuuugag gugcguguuu     1020

gugccugucc ugggagagac cggcgcacag aggaagagaa ucuccgcaag aaaggggagc     1080

cucaccacga gcugccccca gggagcacua agcgagcacu gcccaacaac accagcuccu     1140

cuccccagcc aaagaagaaa ccacuggaug gagaauauuu cacccuucag auccgugggc     1200

gugagcgcuu cgagauguuc cgagagcuga augaggccuu ggaacucaag gaugcccagg     1260

cugggaagga gccagggggg agcagggcuc acuccagcca ccugaagucc aaaaaggguc     1320

agucuaccuc ccgccauaaa aaacucaugu ucaagacaga agggccugac ucagacugac     1380

auucuccacu ucuuguuccc cacugacagc cucccacccc caucucuccc uccccugcca     1440

uuuuggguuu ugggucuuug aacccuugcu ugcaauaggu gugcgucaga agcacccagg     1500

acuuccauuu gcuuuguccc ggggcuccac ugaacaaguu ggccugcacu gguguuuugu     1560

uguggggagg aggaugggga guaggacaua ccagcuuaga uuuuaagguu uuuacuguga     1620

gggauguuug ggagauguaa gaaauguucu ugcaguuaag gguuaguuua caaucagcca     1680

cauucuaggu aggggcccac uucaccguac uaaccaggga agcugucccu cacuguugaa     1740

uuuucucuaa cuucaaggcc cauaucugug aaaugcuggc auuugcaccu accucacaga     1800

gugcauugug aggguuaaug aaauaaugua caucuggccu ugaaaccacc uuuuauuaca     1860

uggggucuag aacuugaccc ccuugagggu gcuuguuccc ucucccuguu ggucgguggg     1920

uugguaguuu cuacaguugg gcagcugguu agguagaggg aguugucaag ucucugcugg     1980

cccagccaaa cccugucuga caaccucuug gugaaccuua guaccuaaaa ggaaaucuca     2040

ccccauccca cacccuggag gauuucaucu cuuguauaug augaucugga uccaccaaga     2100

cuuguuuuau gcucaggguc aauuucuuuu uucuuuuuuu uuuuuuuuuu ucuuuuucuu     2160

ugagacuggg ucucgcuuug uugcccaggc uggaguggag uggcgugauc uuggcuuacu     2220

gcagccuuug ccuccccggc ucgagcaguc cugccucagc cuccggagua gcugggacca     2280

cagguucaug ccaccauggc cagccaacuu uugcauguuu uguagagaug gggucucaca     2340

guguugccca ggcuggucuc aaacuccugg gcucaggcga uccaccuguc ucagccuccc     2400

agagugcugg gauuacaauu gugagccacc acguccagcu ggaaggguca acaucuuuua     2460

cauucugcaa gcacaucugc auuuucaccc cacccuuccc cuccuucucc cuuuuuauau     2520

cccauuuuua uaucgaucuc uuauuuuaca auaaaacuuu gcugccaccu gugugucuga     2580

ggggug                                                                2586


<210>  2
<211>  2583
<212>  RNA
<213>  Homo sapiens

<400>  2
gauugggguu uuccccuccc augugcucaa gacuggcgcu aaaaguuuug agcuucucaa       60

aagucuagag ccaccgucca gggagcaggu agcugcuggg cuccggggac acuuugcguu      120

cgggcuggga gcgugcuuuc cacgacggug acacgcuucc cuggauuggc cagacugccu      180

uccgggucac ugccauggag gagccgcagu cagauccuag cgucgagccc ccucugaguc      240

aggaaacauu uucagaccua uggaaacuac uuccugaaaa caacguucug ucccccuugc      300

cgucccaagc aauggaugau uugaugcugu ccccggacga uauugaacaa ugguucacug      360

aagacccagg uccagaugaa gcucccagaa ugccagaggc ugcucccccc guggccccug      420

caccagcagc uccuacaccg gcggccccug caccagcccc cuccuggccc cugucaucuu      480

cugucccuuc ccagaaaacc uaccagggca gcuacgguuu ccgucugggc uucuugcauu      540

cugggacagc caagucugug acuugcacgu acuccccugc ccucaacaag auguuuugcc      600

aacuggccaa gaccugcccu gugcagcugu ggguugauuc cacacccccg cccggcaccc      660

gcguccgcgc cauggccauc uacaagcagu cacagcacau gacggagguu gugaggcgcu      720

gcccccacca ugagcgcugc ucagauagcg auggucuggc cccuccucag caucuuaucc      780

gaguggaagg aaauuugcgu guggaguauu uggaugacag aaacacuuuu cgacauagug      840

ugguggugcc cuaugagccg ccugagguug gcucugacug uaccaccauc cacuacaacu      900

acauguguaa caguuccugc augggcggca ugaaccggag gcccauccuc accaucauca      960

cacuggaaga cuccaguggu aaucuacugg gacggaacag cuuugaggug cguguuugug     1020

ccuguccugg gagagaccgg cgcacagagg aagagaaucu ccgcaagaaa ggggagccuc     1080

accacgagcu gcccccaggg agcacuaagc gagcacugcc caacaacacc agcuccucuc     1140

cccagccaaa gaagaaacca cuggauggag aauauuucac ccuucagauc cgugggcgug     1200

agcgcuucga gauguuccga gagcugaaug aggccuugga acucaaggau gcccaggcug     1260

ggaaggagcc aggggggagc agggcucacu ccagccaccu gaaguccaaa aagggucagu     1320

cuaccucccg ccauaaaaaa cucauguuca agacagaagg gccugacuca gacugacauu     1380

cuccacuucu uguuccccac ugacagccuc ccacccccau cucucccucc ccugccauuu     1440

uggguuuugg gucuuugaac ccuugcuugc aauaggugug cgucagaagc acccaggacu     1500

uccauuugcu uugucccggg gcuccacuga acaaguuggc cugcacuggu guuuuguugu     1560

ggggaggagg auggggagua ggacauacca gcuuagauuu uaagguuuuu acugugaggg     1620

auguuuggga gauguaagaa auguucuugc aguuaagggu uaguuuacaa ucagccacau     1680

ucuagguagg ggcccacuuc accguacuaa ccagggaagc ugucccucac uguugaauuu     1740

ucucuaacuu caaggcccau aucugugaaa ugcuggcauu ugcaccuacc ucacagagug     1800

cauugugagg guuaaugaaa uaauguacau cuggccuuga aaccaccuuu uauuacaugg     1860

ggucuagaac uugacccccu ugagggugcu uguucccucu cccuguuggu cgguggguug     1920

guaguuucua caguugggca gcugguuagg uagagggagu ugucaagucu cugcuggccc     1980

agccaaaccc ugucugacaa ccucuuggug aaccuuagua ccuaaaagga aaucucaccc     2040

caucccacac ccuggaggau uucaucucuu guauaugaug aucuggaucc accaagacuu     2100

guuuuaugcu cagggucaau uucuuuuuuc uuuuuuuuuu uuuuuuuucu uuuucuuuga     2160

gacugggucu cgcuuuguug cccaggcugg aguggagugg cgugaucuug gcuuacugca     2220

gccuuugccu ccccggcucg agcaguccug ccucagccuc cggaguagcu gggaccacag     2280

guucaugcca ccauggccag ccaacuuuug cauguuuugu agagaugggg ucucacagug     2340

uugcccaggc uggucucaaa cuccugggcu caggcgaucc accugucuca gccucccaga     2400

gugcugggau uacaauugug agccaccacg uccagcugga agggucaaca ucuuuuacau     2460

ucugcaagca caucugcauu uucaccccac ccuuccccuc cuucucccuu uuuauauccc     2520

auuuuuauau cgaucucuua uuuuacaaua aaacuuugcu gccaccugug ugucugaggg     2580

gug                                                                   2583


<210>  3
<211>  2719
<212>  RNA
<213>  Homo sapiens

<400>  3
gauugggguu uuccccuccc augugcucaa gacuggcgcu aaaaguuuug agcuucucaa       60

aagucuagag ccaccgucca gggagcaggu agcugcuggg cuccggggac acuuugcguu      120

cgggcuggga gcgugcuuuc cacgacggug acacgcuucc cuggauuggc agccagacug      180

ccuuccgggu cacugccaug gaggagccgc agucagaucc uagcgucgag cccccucuga      240

gucaggaaac auuuucagac cuauggaaac uacuuccuga aaacaacguu cugucccccu      300

ugccguccca agcaauggau gauuugaugc uguccccgga cgauauugaa caaugguuca      360

cugaagaccc agguccagau gaagcuccca gaaugccaga ggcugcuccc cccguggccc      420

cugcaccagc agcuccuaca ccggcggccc cugcaccagc ccccuccugg ccccugucau      480

cuucuguccc uucccagaaa accuaccagg gcagcuacgg uuuccgucug ggcuucuugc      540

auucugggac agccaagucu gugacuugca cguacucccc ugcccucaac aagauguuuu      600

gccaacuggc caagaccugc ccugugcagc uguggguuga uuccacaccc ccgcccggca      660

cccgcguccg cgccauggcc aucuacaagc agucacagca caugacggag guugugaggc      720

gcugccccca ccaugagcgc ugcucagaua gcgauggucu ggccccuccu cagcaucuua      780

uccgagugga aggaaauuug cguguggagu auuuggauga cagaaacacu uuucgacaua      840

gugugguggu gcccuaugag ccgccugagg uuggcucuga cuguaccacc auccacuaca      900

acuacaugug uaacaguucc ugcaugggcg gcaugaaccg gaggcccauc cucaccauca      960

ucacacugga agacuccagu gguaaucuac ugggacggaa cagcuuugag gugcguguuu     1020

gugccugucc ugggagagac cggcgcacag aggaagagaa ucuccgcaag aaaggggagc     1080

cucaccacga gcugccccca gggagcacua agcgagcacu gcccaacaac accagcuccu     1140

cuccccagcc aaagaagaaa ccacuggaug gagaauauuu cacccuucag gaccagacca     1200

gcuuucaaaa agaaaauugu uaaagagagc augaaaaugg uucuaugacu uugccugaua     1260

cagaugcuac uugacuuacg augguguuac uuccugauaa acucgucgua aguugaaaau     1320

auuauccgug ggcgugagcg cuucgagaug uuccgagagc ugaaugaggc cuuggaacuc     1380

aaggaugccc aggcugggaa ggagccaggg gggagcaggg cucacuccag ccaccugaag     1440

uccaaaaagg gucagucuac cucccgccau aaaaaacuca uguucaagac agaagggccu     1500

gacucagacu gacauucucc acuucuuguu ccccacugac agccucccac ccccaucucu     1560

cccuccccug ccauuuuggg uuuugggucu uugaacccuu gcuugcaaua ggugugcguc     1620

agaagcaccc aggacuucca uuugcuuugu cccggggcuc cacugaacaa guuggccugc     1680

acugguguuu uguugugggg aggaggaugg ggaguaggac auaccagcuu agauuuuaag     1740

guuuuuacug ugagggaugu uugggagaug uaagaaaugu ucuugcaguu aaggguuagu     1800

uuacaaucag ccacauucua gguaggggcc cacuucaccg uacuaaccag ggaagcuguc     1860

ccucacuguu gaauuuucuc uaacuucaag gcccauaucu gugaaaugcu ggcauuugca     1920

ccuaccucac agagugcauu gugaggguua augaaauaau guacaucugg ccuugaaacc     1980

accuuuuauu acaugggguc uagaacuuga cccccuugag ggugcuuguu cccucucccu     2040

guuggucggu ggguugguag uuucuacagu ugggcagcug guuagguaga gggaguuguc     2100

aagucucugc uggcccagcc aaacccuguc ugacaaccuc uuggugaacc uuaguaccua     2160

aaaggaaauc ucaccccauc ccacacccug gaggauuuca ucucuuguau augaugaucu     2220

ggauccacca agacuuguuu uaugcucagg gucaauuucu uuuuucuuuu uuuuuuuuuu     2280

uuuucuuuuu cuuugagacu gggucucgcu uuguugccca ggcuggagug gaguggcgug     2340

aucuuggcuu acugcagccu uugccucccc ggcucgagca guccugccuc agccuccgga     2400

guagcuggga ccacagguuc augccaccau ggccagccaa cuuuugcaug uuuuguagag     2460

auggggucuc acaguguugc ccaggcuggu cucaaacucc ugggcucagg cgauccaccu     2520

gucucagccu cccagagugc ugggauuaca auugugagcc accacgucca gcuggaaggg     2580

ucaacaucuu uuacauucug caagcacauc ugcauuuuca ccccacccuu ccccuccuuc     2640

ucccuuuuua uaucccauuu uuauaucgau cucuuauuuu acaauaaaac uuugcugcca     2700

ccuguguguc ugaggggug                                                  2719


<210>  4
<211>  2646
<212>  RNA
<213>  Homo sapiens

<400>  4
gauugggguu uuccccuccc augugcucaa gacuggcgcu aaaaguuuug agcuucucaa       60

aagucuagag ccaccgucca gggagcaggu agcugcuggg cuccggggac acuuugcguu      120

cgggcuggga gcgugcuuuc cacgacggug acacgcuucc cuggauuggc agccagacug      180

ccuuccgggu cacugccaug gaggagccgc agucagaucc uagcgucgag cccccucuga      240

gucaggaaac auuuucagac cuauggaaac uacuuccuga aaacaacguu cugucccccu      300

ugccguccca agcaauggau gauuugaugc uguccccgga cgauauugaa caaugguuca      360

cugaagaccc agguccagau gaagcuccca gaaugccaga ggcugcuccc cccguggccc      420

cugcaccagc agcuccuaca ccggcggccc cugcaccagc ccccuccugg ccccugucau      480

cuucuguccc uucccagaaa accuaccagg gcagcuacgg uuuccgucug ggcuucuugc      540

auucugggac agccaagucu gugacuugca cguacucccc ugcccucaac aagauguuuu      600

gccaacuggc caagaccugc ccugugcagc uguggguuga uuccacaccc ccgcccggca      660

cccgcguccg cgccauggcc aucuacaagc agucacagca caugacggag guugugaggc      720

gcugccccca ccaugagcgc ugcucagaua gcgauggucu ggccccuccu cagcaucuua      780

uccgagugga aggaaauuug cguguggagu auuuggauga cagaaacacu uuucgacaua      840

gugugguggu gcccuaugag ccgccugagg uuggcucuga cuguaccacc auccacuaca      900

acuacaugug uaacaguucc ugcaugggcg gcaugaaccg gaggcccauc cucaccauca      960

ucacacugga agacuccagu gguaaucuac ugggacggaa cagcuuugag gugcguguuu     1020

gugccugucc ugggagagac cggcgcacag aggaagagaa ucuccgcaag aaaggggagc     1080

cucaccacga gcugccccca gggagcacua agcgagcacu gcccaacaac accagcuccu     1140

cuccccagcc aaagaagaaa ccacuggaug gagaauauuu cacccuucag augcuacuug     1200

acuuacgaug guguuacuuc cugauaaacu cgucguaagu ugaaaauauu auccgugggc     1260

gugagcgcuu cgagauguuc cgagagcuga augaggccuu ggaacucaag gaugcccagg     1320

cugggaagga gccagggggg agcagggcuc acuccagcca ccugaagucc aaaaaggguc     1380

agucuaccuc ccgccauaaa aaacucaugu ucaagacaga agggccugac ucagacugac     1440

auucuccacu ucuuguuccc cacugacagc cucccacccc caucucuccc uccccugcca     1500

uuuuggguuu ugggucuuug aacccuugcu ugcaauaggu gugcgucaga agcacccagg     1560

acuuccauuu gcuuuguccc ggggcuccac ugaacaaguu ggccugcacu gguguuuugu     1620

uguggggagg aggaugggga guaggacaua ccagcuuaga uuuuaagguu uuuacuguga     1680

gggauguuug ggagauguaa gaaauguucu ugcaguuaag gguuaguuua caaucagcca     1740

cauucuaggu aggggcccac uucaccguac uaaccaggga agcugucccu cacuguugaa     1800

uuuucucuaa cuucaaggcc cauaucugug aaaugcuggc auuugcaccu accucacaga     1860

gugcauugug aggguuaaug aaauaaugua caucuggccu ugaaaccacc uuuuauuaca     1920

uggggucuag aacuugaccc ccuugagggu gcuuguuccc ucucccuguu ggucgguggg     1980

uugguaguuu cuacaguugg gcagcugguu agguagaggg aguugucaag ucucugcugg     2040

cccagccaaa cccugucuga caaccucuug gugaaccuua guaccuaaaa ggaaaucuca     2100

ccccauccca cacccuggag gauuucaucu cuuguauaug augaucugga uccaccaaga     2160

cuuguuuuau gcucaggguc aauuucuuuu uucuuuuuuu uuuuuuuuuu ucuuuuucuu     2220

ugagacuggg ucucgcuuug uugcccaggc uggaguggag uggcgugauc uuggcuuacu     2280

gcagccuuug ccuccccggc ucgagcaguc cugccucagc cuccggagua gcugggacca     2340

cagguucaug ccaccauggc cagccaacuu uugcauguuu uguagagaug gggucucaca     2400

guguugccca ggcuggucuc aaacuccugg gcucaggcga uccaccuguc ucagccuccc     2460

agagugcugg gauuacaauu gugagccacc acguccagcu ggaaggguca acaucuuuua     2520

cauucugcaa gcacaucugc auuuucaccc cacccuuccc cuccuucucc cuuuuuauau     2580

cccauuuuua uaucgaucuc uuauuuuaca auaaaacuuu gcugccaccu gugugucuga     2640

ggggug                                                                2646


<210>  5
<211>  2271
<212>  RNA
<213>  Homo sapiens

<400>  5
ugaggccagg agauggaggc ugcagugagc ugugaucaca ccacugugcu ccagccugag       60

ugacagagca agacccuauc ucaaaaaaaa aaaaaaaaaa gaaaagcucc ugagguguag      120

acgccaacuc ucucuagcuc gcuagugggu ugcaggaggu gcuuacgcau guuuguuucu      180

uugcugccgu cuuccaguug cuuuaucugu ucacuugugc ccugacuuuc aacucugucu      240

ccuuccucuu ccuacaguac uccccugccc ucaacaagau guuuugccaa cuggccaaga      300

ccugcccugu gcagcugugg guugauucca cacccccgcc cggcacccgc guccgcgcca      360

uggccaucua caagcaguca cagcacauga cggagguugu gaggcgcugc ccccaccaug      420

agcgcugcuc agauagcgau ggucuggccc cuccucagca ucuuauccga guggaaggaa      480

auuugcgugu ggaguauuug gaugacagaa acacuuuucg acauagugug guggugcccu      540

augagccgcc ugagguuggc ucugacugua ccaccaucca cuacaacuac auguguaaca      600

guuccugcau gggcggcaug aaccggaggc ccauccucac caucaucaca cuggaagacu      660

ccagugguaa ucuacuggga cggaacagcu uugaggugcg uguuugugcc uguccuggga      720

gagaccggcg cacagaggaa gagaaucucc gcaagaaagg ggagccucac cacgagcugc      780

ccccagggag cacuaagcga gcacugccca acaacaccag cuccucuccc cagccaaaga      840

agaaaccacu ggauggagaa uauuucaccc uucagauccg ugggcgugag cgcuucgaga      900

uguuccgaga gcugaaugag gccuuggaac ucaaggaugc ccaggcuggg aaggagccag      960

gggggagcag ggcucacucc agccaccuga aguccaaaaa gggucagucu accucccgcc     1020

auaaaaaacu cauguucaag acagaagggc cugacucaga cugacauucu ccacuucuug     1080

uuccccacug acagccuccc acccccaucu cucccucccc ugccauuuug gguuuugggu     1140

cuuugaaccc uugcuugcaa uaggugugcg ucagaagcac ccaggacuuc cauuugcuuu     1200

gucccggggc uccacugaac aaguuggccu gcacuggugu uuuguugugg ggaggaggau     1260

ggggaguagg acauaccagc uuagauuuua agguuuuuac ugugagggau guuugggaga     1320

uguaagaaau guucuugcag uuaaggguua guuuacaauc agccacauuc uagguagggg     1380

cccacuucac cguacuaacc agggaagcug ucccucacug uugaauuuuc ucuaacuuca     1440

aggcccauau cugugaaaug cuggcauuug caccuaccuc acagagugca uugugagggu     1500

uaaugaaaua auguacaucu ggccuugaaa ccaccuuuua uuacaugggg ucuagaacuu     1560

gacccccuug agggugcuug uucccucucc cuguuggucg guggguuggu aguuucuaca     1620

guugggcagc ugguuaggua gagggaguug ucaagucucu gcuggcccag ccaaacccug     1680

ucugacaacc ucuuggugaa ccuuaguacc uaaaaggaaa ucucacccca ucccacaccc     1740

uggaggauuu caucucuugu auaugaugau cuggauccac caagacuugu uuuaugcuca     1800

gggucaauuu cuuuuuucuu uuuuuuuuuu uuuuuucuuu uucuuugaga cugggucucg     1860

cuuuguugcc caggcuggag uggaguggcg ugaucuuggc uuacugcagc cuuugccucc     1920

ccggcucgag caguccugcc ucagccuccg gaguagcugg gaccacaggu ucaugccacc     1980

auggccagcc aacuuuugca uguuuuguag agaugggguc ucacaguguu gcccaggcug     2040

gucucaaacu ccugggcuca ggcgauccac cugucucagc cucccagagu gcugggauua     2100

caauugugag ccaccacguc cagcuggaag ggucaacauc uuuuacauuc ugcaagcaca     2160

ucugcauuuu caccccaccc uuccccuccu ucucccuuuu uauaucccau uuuuauaucg     2220

aucucuuauu uuacaauaaa acuuugcugc caccugugug ucugaggggu g              2271


<210>  6
<211>  2404
<212>  RNA
<213>  Homo sapiens

<400>  6
ugaggccagg agauggaggc ugcagugagc ugugaucaca ccacugugcu ccagccugag       60

ugacagagca agacccuauc ucaaaaaaaa aaaaaaaaaa gaaaagcucc ugagguguag      120

acgccaacuc ucucuagcuc gcuagugggu ugcaggaggu gcuuacgcau guuuguuucu      180

uugcugccgu cuuccaguug cuuuaucugu ucacuugugc ccugacuuuc aacucugucu      240

ccuuccucuu ccuacaguac uccccugccc ucaacaagau guuuugccaa cuggccaaga      300

ccugcccugu gcagcugugg guugauucca cacccccgcc cggcacccgc guccgcgcca      360

uggccaucua caagcaguca cagcacauga cggagguugu gaggcgcugc ccccaccaug      420

agcgcugcuc agauagcgau ggucuggccc cuccucagca ucuuauccga guggaaggaa      480

auuugcgugu ggaguauuug gaugacagaa acacuuuucg acauagugug guggugcccu      540

augagccgcc ugagguuggc ucugacugua ccaccaucca cuacaacuac auguguaaca      600

guuccugcau gggcggcaug aaccggaggc ccauccucac caucaucaca cuggaagacu      660

ccagugguaa ucuacuggga cggaacagcu uugaggugcg uguuugugcc uguccuggga      720

gagaccggcg cacagaggaa gagaaucucc gcaagaaagg ggagccucac cacgagcugc      780

ccccagggag cacuaagcga gcacugccca acaacaccag cuccucuccc cagccaaaga      840

agaaaccacu ggauggagaa uauuucaccc uucaggacca gaccagcuuu caaaaagaaa      900

auuguuaaag agagcaugaa aaugguucua ugacuuugcc ugauacagau gcuacuugac      960

uuacgauggu guuacuuccu gauaaacucg ucguaaguug aaaauauuau ccgugggcgu     1020

gagcgcuucg agauguuccg agagcugaau gaggccuugg aacucaagga ugcccaggcu     1080

gggaaggagc caggggggag cagggcucac uccagccacc ugaaguccaa aaagggucag     1140

ucuaccuccc gccauaaaaa acucauguuc aagacagaag ggccugacuc agacugacau     1200

ucuccacuuc uuguucccca cugacagccu cccaccccca ucucucccuc cccugccauu     1260

uuggguuuug ggucuuugaa cccuugcuug caauaggugu gcgucagaag cacccaggac     1320

uuccauuugc uuugucccgg ggcuccacug aacaaguugg ccugcacugg uguuuuguug     1380

uggggaggag gauggggagu aggacauacc agcuuagauu uuaagguuuu uacugugagg     1440

gauguuuggg agauguaaga aauguucuug caguuaaggg uuaguuuaca aucagccaca     1500

uucuagguag gggcccacuu caccguacua accagggaag cugucccuca cuguugaauu     1560

uucucuaacu ucaaggccca uaucugugaa augcuggcau uugcaccuac cucacagagu     1620

gcauugugag gguuaaugaa auaauguaca ucuggccuug aaaccaccuu uuauuacaug     1680

gggucuagaa cuugaccccc uugagggugc uuguucccuc ucccuguugg ucgguggguu     1740

gguaguuucu acaguugggc agcugguuag guagagggag uugucaaguc ucugcuggcc     1800

cagccaaacc cugucugaca accucuuggu gaaccuuagu accuaaaagg aaaucucacc     1860

ccaucccaca cccuggagga uuucaucucu uguauaugau gaucuggauc caccaagacu     1920

uguuuuaugc ucagggucaa uuucuuuuuu cuuuuuuuuu uuuuuuuuuc uuuuucuuug     1980

agacuggguc ucgcuuuguu gcccaggcug gaguggagug gcgugaucuu ggcuuacugc     2040

agccuuugcc uccccggcuc gagcaguccu gccucagccu ccggaguagc ugggaccaca     2100

gguucaugcc accauggcca gccaacuuuu gcauguuuug uagagauggg gucucacagu     2160

guugcccagg cuggucucaa acuccugggc ucaggcgauc caccugucuc agccucccag     2220

agugcuggga uuacaauugu gagccaccac guccagcugg aagggucaac aucuuuuaca     2280

uucugcaagc acaucugcau uuucacccca cccuuccccu ccuucucccu uuuuauaucc     2340

cauuuuuaua ucgaucucuu auuuuacaau aaaacuuugc ugccaccugu gugucugagg     2400

ggug                                                                  2404


<210>  7
<211>  2331
<212>  RNA
<213>  Homo sapiens

<400>  7
ugaggccagg agauggaggc ugcagugagc ugugaucaca ccacugugcu ccagccugag       60

ugacagagca agacccuauc ucaaaaaaaa aaaaaaaaaa gaaaagcucc ugagguguag      120

acgccaacuc ucucuagcuc gcuagugggu ugcaggaggu gcuuacgcau guuuguuucu      180

uugcugccgu cuuccaguug cuuuaucugu ucacuugugc ccugacuuuc aacucugucu      240

ccuuccucuu ccuacaguac uccccugccc ucaacaagau guuuugccaa cuggccaaga      300

ccugcccugu gcagcugugg guugauucca cacccccgcc cggcacccgc guccgcgcca      360

uggccaucua caagcaguca cagcacauga cggagguugu gaggcgcugc ccccaccaug      420

agcgcugcuc agauagcgau ggucuggccc cuccucagca ucuuauccga guggaaggaa      480

auuugcgugu ggaguauuug gaugacagaa acacuuuucg acauagugug guggugcccu      540

augagccgcc ugagguuggc ucugacugua ccaccaucca cuacaacuac auguguaaca      600

guuccugcau gggcggcaug aaccggaggc ccauccucac caucaucaca cuggaagacu      660

ccagugguaa ucuacuggga cggaacagcu uugaggugcg uguuugugcc uguccuggga      720

gagaccggcg cacagaggaa gagaaucucc gcaagaaagg ggagccucac cacgagcugc      780

ccccagggag cacuaagcga gcacugccca acaacaccag cuccucuccc cagccaaaga      840

agaaaccacu ggauggagaa uauuucaccc uucagaugcu acuugacuua cgaugguguu      900

acuuccugau aaacucgucg uaaguugaaa auauuauccg ugggcgugag cgcuucgaga      960

uguuccgaga gcugaaugag gccuuggaac ucaaggaugc ccaggcuggg aaggagccag     1020

gggggagcag ggcucacucc agccaccuga aguccaaaaa gggucagucu accucccgcc     1080

auaaaaaacu cauguucaag acagaagggc cugacucaga cugacauucu ccacuucuug     1140

uuccccacug acagccuccc acccccaucu cucccucccc ugccauuuug gguuuugggu     1200

cuuugaaccc uugcuugcaa uaggugugcg ucagaagcac ccaggacuuc cauuugcuuu     1260

gucccggggc uccacugaac aaguuggccu gcacuggugu uuuguugugg ggaggaggau     1320

ggggaguagg acauaccagc uuagauuuua agguuuuuac ugugagggau guuugggaga     1380

uguaagaaau guucuugcag uuaaggguua guuuacaauc agccacauuc uagguagggg     1440

cccacuucac cguacuaacc agggaagcug ucccucacug uugaauuuuc ucuaacuuca     1500

aggcccauau cugugaaaug cuggcauuug caccuaccuc acagagugca uugugagggu     1560

uaaugaaaua auguacaucu ggccuugaaa ccaccuuuua uuacaugggg ucuagaacuu     1620

gacccccuug agggugcuug uucccucucc cuguuggucg guggguuggu aguuucuaca     1680

guugggcagc ugguuaggua gagggaguug ucaagucucu gcuggcccag ccaaacccug     1740

ucugacaacc ucuuggugaa ccuuaguacc uaaaaggaaa ucucacccca ucccacaccc     1800

uggaggauuu caucucuugu auaugaugau cuggauccac caagacuugu uuuaugcuca     1860

gggucaauuu cuuuuuucuu uuuuuuuuuu uuuuuucuuu uucuuugaga cugggucucg     1920

cuuuguugcc caggcuggag uggaguggcg ugaucuuggc uuacugcagc cuuugccucc     1980

ccggcucgag caguccugcc ucagccuccg gaguagcugg gaccacaggu ucaugccacc     2040

auggccagcc aacuuuugca uguuuuguag agaugggguc ucacaguguu gcccaggcug     2100

gucucaaacu ccugggcuca ggcgauccac cugucucagc cucccagagu gcugggauua     2160

caauugugag ccaccacguc cagcuggaag ggucaacauc uuuuacauuc ugcaagcaca     2220

ucugcauuuu caccccaccc uuccccuccu ucucccuuuu uauaucccau uuuuauaucg     2280

aucucuuauu uuacaauaaa acuuugcugc caccugugug ucugaggggu g              2331


<210>  8
<211>  1877
<212>  RNA
<213>  Mus musculus

<400>  8
uuuccccucc cacgugcuca cccuggcuaa aguucuguag cuucaguuca uugggaccau       60

ccuggcugua gguagcgacu acaguuaggg ggcaccuagc auucaggccc ucauccuccu      120

ccuucccagc agggugucac gcuucuccga agacuggaug acugccaugg aggagucaca      180

gucggauauc agccucgagc ucccucugag ccaggagaca uuuucaggcu uauggaaacu      240

acuuccucca gaagauaucc ugccaucacc ucacugcaug gacgaucugu ugcugcccca      300

ggauguugag gaguuuuuug aaggcccaag ugaagcccuc cgagugucag gagcuccugc      360

agcacaggac ccugucaccg agaccccugg gccaguggcc ccugccccag ccacuccaug      420

gccccuguca ucuuuugucc cuucucaaaa aacuuaccag ggcaacuaug gcuuccaccu      480

gggcuuccug cagucuggga cagccaaguc uguuaugugc acguacucuc cuccccucaa      540

uaagcuauuc ugccagcugg cgaagacgug cccugugcag uuguggguca gcgccacacc      600

uccagcuggg agccgugucc gcgccauggc caucuacaag aagucacagc acaugacgga      660

ggucgugaga cgcugccccc accaugagcg cugcuccgau ggugauggcc uggcuccucc      720

ccagcaucuu auccgggugg aaggaaauuu guaucccgag uaucuggaag acaggcagac      780

uuuucgccac agcguggugg uaccuuauga gccacccgag gccggcucug aguauaccac      840

cauccacuac aaguacaugu guaauagcuc cugcaugggg ggcaugaacc gccgaccuau      900

ccuuaccauc aucacacugg aagacuccag ugggaaccuu cugggacggg acagcuuuga      960

gguucguguu ugugccugcc cugggagaga ccgccguaca gaagaagaaa auuuccgcaa     1020

aaaggaaguc cuuugcccug aacugccccc agggagcgca aagagagcgc ugcccaccug     1080

cacaagcgcc ucucccccgc aaaagaaaaa accacuugau ggagaguauu ucacccucaa     1140

gauccgcggg cguaaacgcu ucgagauguu ccgggagcug aaugaggccu uagaguuaaa     1200

ggaugcccau gcuacagagg agucuggaga cagcagggcu cacuccagcc uccagccuag     1260

agccuuccaa gccuugauca aggaggaaag cccaaacugc uagcucccau cacuucaucc     1320

cuccccuuuu cugucuuccu auagcuaccu gaagaccaag aagggccagu cuacuucccg     1380

ccauaaaaaa acaaugguca agaaaguggg gccugacuca gacugacugc cucugcaucc     1440

cguccccauc accagccucc cccucuccuu gcugucuuau gacuucaggg cugagacaca     1500

auccucccgg ucccuucugc ugccuuuuuu accuuguagc uagggcucag cccccucucu     1560

gaguaguggu uccuggccca aguuggggaa uagguugaua guugucaggu cucugcuggc     1620

ccagcgaaau ucuauccagc caguuguugg acccuggcac cuacaaugaa aucucacccu     1680

accccacacc cuguaagauu cuaucuuggg cccucauagg guccauaucc uccagggccu     1740

acuuuccuuc cauucugcaa agccugucug cauuuaucca ccccccaccc ugucucccuc     1800

uuuuuuuuuu uuuuaccccu uuuuauauau caauuuccua uuuuacaaua aaauuuuguu     1860

aucacuuaaa aaaaaaa                                                    1877


<210>  9
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARN de interferencia, posiciones 544-563

<400>  10
acagacuugg cugucccagt t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARN de interferencia, posiciones 902-920

<400>  11
ggagcuauua cacauguact t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARN de interferencia, posiciones 958-977

<400>  12
gagucuucca gugugaugat t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARN inactivo posiciones 544-563

<400>  13
cugggacagc caagucugut t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARN inactivo posiciones 902-920

<400>  14
guacaugugu aauagcucct t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARN inactivo posiciones 958-977

<400>  15
ucaucacacu ggaagacuct t                                                 21


<210>  16
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Thr Ala Ala Val Leu Ser Cys Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Ala Thr Arg Gly Ala Gln Met Gly Leu Ala Pro Met Glu Gly Ile Arg 
            20                  25                  30          


Arg Pro Asp Gln Ala Leu Leu Pro Glu Leu Pro Gly Leu Gly Leu Arg 
        35                  40                  45              


Ala Pro Leu Lys Lys Thr Thr Ala Glu Gln Ala Glu Glu Asp Leu Leu 
    50                  55                  60                  


Gln Glu Ala Gln Ala Leu Ala Glu Val Leu Asp Leu Gln Asp Arg Glu 
65                  70                  75                  80  


Pro Arg Ser Ser Arg Arg Cys Val Arg Leu His Glu Ser Cys Leu Gly 
                85                  90                  95      


Gln Gln Val Pro Cys Cys Asp Pro Cys Ala Thr Cys Tyr Cys Arg Phe 
            100                 105                 110         


Phe Asn Ala Phe Cys Tyr Cys Arg Lys Leu Gly Thr Ala Met Asn Pro 
        115                 120                 125             


Cys Ser Arg Thr 
    130         


<210>  17
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Arg Ser Cys Cys Ser Arg Ser Gly Ala Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Gln Ala Ser Met Glu Val Arg Gly Trp Cys Leu Glu Ser Ser 
            20                  25                  30          


Gln Cys Gln Asp Leu Thr Thr Glu Ser Asn Leu Leu Glu Cys Ile Arg 
        35                  40                  45              


Ala Cys Lys Pro Asp Leu Ser Ala Glu Thr Pro Met Phe Pro Gly Asn 
    50                  55                  60                  


Gly Asp Glu Gln Pro Leu Thr Glu Asn Pro Arg Lys Tyr Val Met Gly 
65                  70                  75                  80  


His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser Ser Ser Ser Gly 
                85                  90                  95      


Ser Ser Gly Ala Gly Gln Lys Arg Glu Asp Val Ser Ala Gly Glu Asp 
            100                 105                 110         


Cys Gly Pro Leu Pro Glu Gly Gly Pro Glu Pro Arg Ser Asp Gly Ala 
        115                 120                 125             


Lys Pro Gly Pro Arg Glu Gly Lys Arg Ser Tyr Ser Met Glu His Phe 
    130                 135                 140                 


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
145                 150                 155                 160 


Pro Asn Gly Ala Asp Asp Glu Ser Ala Glu Ala Phe Pro Leu Glu Phe 
                165                 170                 175     


Lys Arg Glu Leu Thr Gly Gln Arg Leu Arg Glu Gly Asp Gly Pro Asp 
            180                 185                 190         


Gly Pro Ala Asp Asp Gly Ala Gly Ala Gln Ala Asp Leu Glu His Ser 
        195                 200                 205             


Leu Leu Val Ala Ala Glu Lys Lys Asp Glu Gly Pro Tyr Arg Met Glu 
    210                 215                 220                 


His Phe Arg Trp Gly Ser Pro Pro Lys Asp Lys Arg Tyr Gly Gly Phe 
225                 230                 235                 240 


Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr Leu Phe Lys Asn 
                245                 250                 255     


Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu 
            260                 265         


<210>  18
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Ser Ser Arg Val Arg Leu Leu Pro Leu Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Met Leu Pro Leu Leu Gly Thr Arg Ala Gln Glu Asp Ala Glu 
            20                  25                  30          


Leu Gln Pro Arg Ala Leu Asp Ile Tyr Ser Ala Val Asp Asp Ala Ser 
        35                  40                  45              


His Glu Lys Glu Leu Ile Glu Ala Leu Gln Glu Val Leu Lys Lys Leu 
    50                  55                  60                  


Lys Ser Lys Arg Val Pro Ile Tyr Glu Lys Lys Tyr Gly Gln Val Pro 
65                  70                  75                  80  


Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg Lys Gly Ala Arg Ile 
                85                  90                  95      


Gly Lys Leu Cys Asp Cys Pro Arg Gly Thr Ser Cys Asn Ser Phe Leu 
            100                 105                 110         


Leu Lys Cys Leu 
        115     


<210>  19
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Glu Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu 
1               5                   10                  15      


Glu Gln Glu Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu 
            20                  25                  30          


Ser Asp Leu Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg 
        35                  40                  45              


Lys Gly Lys Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg 
    50                  55                  60                  


Arg Arg Ser Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr 
65                  70                  75                  80  


Lys Ser Ser Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr 
                85                  90                  95      


Gly Tyr Met Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly 
            100                 105                 110         


Ile Leu Ser Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu 
        115                 120                 125             


Glu Thr Asp Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu 
    130                 135                 140                 


Thr Pro Lys Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met 
145                 150                 155                 160 


Ala Thr Glu Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val 
                165                 170                 175     


Val Lys Tyr Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val 
            180                 185                 190         


Leu Cys Glu Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro 
        195                 200                 205             


Gly Cys Gly Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro 
    210                 215                 220                 


Glu Ser Ser Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val 
225                 230                 235                 240 


Asn Asn Ala Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala 
                245                 250                 255     


Lys Glu Val Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro 
            260                 265                 270         


Val Pro Gly Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr 
        275                 280                 285             


Thr Thr Gly Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu 
    290                 295                 300                 


Gln Gly Ala Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro 
305                 310                 315                 320 


Ala Gly Leu Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys 
                325                 330                 335     


Glu Thr Leu Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys 
            340                 345                 350         


Lys Leu Arg Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly 
        355                 360                 365             


Glu Leu Gln Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn 
    370                 375                 380                 


Phe Lys Met Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala 
385                 390                 395                 400 


Glu Ala Gly His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala 
                405                 410                 415     


Asn Ile Asp Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala 
            420                 425                 430         


Ala Glu Asn Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly 
        435                 440                 445             


Ala Leu Val Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu 
    450                 455                 460                 


Ala Ala Lys Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn 
465                 470                 475                 480 


Gly Gln Met Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met 
                485                 490                 495     


Ile Trp Ala Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu 
            500                 505                 510         


Ser Lys Gly Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys 
        515                 520                 525             


Leu His Trp Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu 
    530                 535                 540                 


Leu Ala Ala Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser 
545                 550                 555                 560 


Pro Leu His Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu 
                565                 570                 575     


Phe Leu Ser Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu 
            580                 585                 590         


Thr Pro Leu Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu 
        595                 600                 605             


Gln Met Ser Lys Ala Leu Gln Asp Ser Ala Pro Asp Arg Pro Ser Pro 
    610                 615                 620                 


Val Glu Arg Ile Val Ser Arg Asp Ile Ala Arg Gly Tyr Glu Arg Ile 
625                 630                 635                 640 


Pro Ile Pro Cys Val Asn Ala Val Asp Ser Glu Pro Cys Pro Ser Asn 
                645                 650                 655     


Tyr Lys Tyr Val Ser Gln Asn Cys Val Thr Ser Pro Met Asn Ile Asp 
            660                 665                 670         


Arg Asn Ile Thr His Leu Gln Tyr Cys Val Cys Ile Asp Asp Cys Ser 
        675                 680                 685             


Ser Ser Asn Cys Met Cys Gly Gln Leu Ser Met Arg Cys Trp Tyr Asp 
    690                 695                 700                 


Lys Asp Gly Arg Leu Leu Pro Glu Phe Asn Met Ala Glu Pro Pro Leu 
705                 710                 715                 720 


Ile Phe Glu Cys Asn His Ala Cys Ser Cys Trp Arg Asn Cys Arg Asn 
                725                 730                 735     


Arg Val Val Gln Asn Gly Leu Arg Ala Arg Leu Gln Leu Tyr Arg Thr 
            740                 745                 750         


Arg Asp Met Gly Trp Gly Val Arg Ser Leu Gln Asp Ile Pro Pro Gly 
        755                 760                 765             


Thr Phe Val Cys Glu Tyr Val Gly Glu Leu Ile Ser Asp Ser Glu Ala 
    770                 775                 780                 


Asp Val Arg Glu Glu Asp Ser Tyr Leu Phe Asp Leu Asp Asn Lys Asp 
785                 790                 795                 800 


Gly Glu Val Tyr Cys Ile Asp Ala Arg Phe Tyr Gly Asn Val Ser Arg 
                805                 810                 815     


Phe Ile Asn His His Cys Glu Pro Asn Leu Val Pro Val Arg Val Phe 
            820                 825                 830         


Met Ala His Gln Asp Leu Arg Phe Pro Arg Ile Ala Phe Phe Ser Thr 
        835                 840                 845             


Arg Leu Ile Glu Ala Gly Glu Gln Leu Gly Phe Asp Tyr Gly Glu Arg 
    850                 855                 860                 


Phe Trp Asp Ile Lys Gly Lys Leu Phe Ser Cys Arg Cys Gly Ser Pro 
865                 870                 875                 880 


Lys Cys Arg His Ser Ser Ala Ala Leu Ala Gln Arg Gln Ala Ser Ala 
                885                 890                 895     


Ala Gln Glu Ala Gln Glu Asp Gly Leu Pro Asp Thr Ser Ser Ala Ala 
            900                 905                 910         


Ala Ala Asp Pro Leu 
        915         


<210>  20
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Gly Asn Lys Arg Leu Gly Leu Ser Gly Leu Thr Leu Ala Leu 
1               5                   10                  15      


Ser Leu Leu Val Cys Leu Gly Ala Leu Ala Glu Ala Tyr Pro Ser Lys 
            20                  25                  30          


Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp Met Ala Arg Tyr 
        35                  40                  45              


Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
65                  70                  75                  80  


Glu Ser Thr Glu Asn Val Pro Arg Thr Arg Leu Glu Asp Pro Ala Met 
                85                  90                  95      


Trp 
    


<210>  21
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Trp Asn Ala Thr Pro Ser Glu Glu Pro Gly Phe Asn Leu Thr Leu 
1               5                   10                  15      


Ala Asp Leu Asp Trp Asp Ala Ser Pro Gly Asn Asp Ser Leu Gly Asp 
            20                  25                  30          


Glu Leu Leu Gln Leu Phe Pro Ala Pro Leu Leu Ala Gly Val Thr Ala 
        35                  40                  45              


Thr Cys Val Ala Leu Phe Val Val Gly Ile Ala Gly Asn Leu Leu Thr 
    50                  55                  60                  


Met Leu Val Val Ser Arg Phe Arg Glu Leu Arg Thr Thr Thr Asn Leu 
65                  70                  75                  80  


Tyr Leu Ser Ser Met Ala Phe Ser Asp Leu Leu Ile Phe Leu Cys Met 
                85                  90                  95      


Pro Leu Asp Leu Val Arg Leu Trp Gln Tyr Arg Pro Trp Asn Phe Gly 
            100                 105                 110         


Asp Leu Leu Cys Lys Leu Phe Gln Phe Val Ser Glu Ser Cys Thr Tyr 
        115                 120                 125             


Ala Thr Val Leu Thr Ile Thr Ala Leu Ser Val Glu Arg Tyr Phe Ala 
    130                 135                 140                 


Ile Cys Phe Pro Leu Arg Ala Lys Val Val Val Thr Lys Gly Arg Val 
145                 150                 155                 160 


Lys Leu Val Ile Phe Val Ile Trp Ala Val Ala Phe Cys Ser Ala Gly 
                165                 170                 175     


Pro Ile Phe Val Leu Val Gly Val Glu His Glu Asn Gly Thr Asp Pro 
            180                 185                 190         


Trp Asp Thr Asn Glu Cys Arg Pro Thr Glu Phe Ala Val Arg Ser Gly 
        195                 200                 205             


Leu Leu Thr Val Met Val Trp Val Ser Ser Ile Phe Phe Phe Leu Pro 
    210                 215                 220                 


Val Phe Cys Leu Thr Val Leu Tyr Ser Leu Ile Gly Arg Lys Leu Trp 
225                 230                 235                 240 


Arg Arg Arg Arg Gly Asp Ala Val Val Gly Ala Ser Leu Arg Asp Gln 
                245                 250                 255     


Asn His Lys Gln Thr Val Lys Met Leu Ala Val Val Val Phe Ala Phe 
            260                 265                 270         


Ile Leu Cys Trp Leu Pro Phe His Val Gly Arg Tyr Leu Phe Ser Lys 
        275                 280                 285             


Ser Phe Glu Pro Gly Ser Leu Glu Ile Ala Gln Ile Ser Gln Tyr Cys 
    290                 295                 300                 


Asn Leu Val Ser Phe Val Leu Phe Tyr Leu Ser Ala Ala Ile Asn Pro 
305                 310                 315                 320 


Ile Leu Tyr Asn Ile Met Ser Lys Lys Tyr Arg Val Ala Val Phe Arg 
                325                 330                 335     


Leu Leu Gly Phe Glu Pro Phe Ser Gln Arg Lys Leu Ser Thr Leu Lys 
            340                 345                 350         


Asp Glu Ser Ser Arg Ala Trp Thr Glu Ser Ser Ile Asn Thr 
        355                 360                 365     


<210>  22
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Val Arg Pro Pro His Lys Ala Pro His Val Val Pro 
        35                  40                  45              


Ala Leu Pro Leu Ser Asn Gln Leu Cys Asp Leu Glu Gln Gln Arg His 
    50                  55                  60                  


Leu Trp Ala Ser Val Phe Ser Gln Ser Thr Lys Asp Ser Gly Ser Asp 
65                  70                  75                  80  


Leu Thr Val Ser Gly Arg Thr Trp Gly Leu Arg Val Leu Asn Arg Leu 
                85                  90                  95      


Phe Pro Pro Ser Ser Arg Glu Arg Ser Arg Arg Ser His Gln Pro Ser 
            100                 105                 110         


Cys Ser Pro Glu Leu 
        115         


