                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  METHOD OF PRODUCTION OF SIALYLATED ANTIBODIES

<130>  FR2011-001 PCT

<160>  63    

<170>  PatentIn version 3.3

<210>  1
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  HC of humanized antiAbeta_13C13_IgG4 mAb


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  1
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  2
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  3
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  LC of humanized antiAbeta_13C13_D260X mAb


<220>
<221>  CDS
<222>  (1)..(660)

<400>  3
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat gga aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag      384
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu         
        115                 120                 125                     

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc      432
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe         
    130                 135                 140                         

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa      480
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln         
145                 150                 155                 160         

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc      528
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser         
                165                 170                 175             

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag      576
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu         
            180                 185                 190                 

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg      624
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser         
        195                 200                 205                     

ccc gtc aca aag agc ttc aac agg gga gag tgt tga                      660
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                             
    210                 215                                             


<210>  4
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  5
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Humanised sequence


<220>
<221>  CDS
<222>  (1)..(345)

<400>  5
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc                                                          345
Val Ser Ser                                                             
        115                                                             


<210>  6
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  7
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanised sequence


<220>
<221>  CDS
<222>  (1)..(339)

<400>  7
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat gga aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt                                                                  339
Arg                                                                     
                                                                        


<210>  8
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  9
<211>  33
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(33)

<400>  9
tcc ggc tac aca ttc act gat tat gct atg cac                           33
Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met His                             
1               5                   10                                  


<210>  10
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  10

Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10      


<210>  11
<211>  30
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(30)

<400>  11
gtt att agt act aag tat ggt aag aca aac                               30
Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn                                 
1               5                   10                                  


<210>  12
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  12

Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn 
1               5                   10  


<210>  13
<211>  18
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(18)

<400>  13
ggg gac gat ggt tat tcc                                               18
Gly Asp Asp Gly Tyr Ser                                                 
1               5                                                       


<210>  14
<211>  6
<212>  PRT
<213>  Mus sp.

<400>  14

Gly Asp Asp Gly Tyr Ser 
1               5       


<210>  15
<211>  48
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(48)

<400>  15
aga tct ggt cag agc ctt gtg cac agt aat gga aac acc tat ctg cat       48
Arg Ser Gly Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His         
1               5                   10                  15              


<210>  16
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  16

Arg Ser Gly Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  17
<211>  24
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(24)

<400>  17
aca gtt tcc aac cga ttt tct ggg                                       24
Thr Val Ser Asn Arg Phe Ser Gly                                         
1               5                                                       


<210>  18
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  18

Thr Val Ser Asn Arg Phe Ser Gly 
1               5               


<210>  19
<211>  27
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(27)

<400>  19
tct caa aat aca ttt gtt cct tgg acg                                   27
Ser Gln Asn Thr Phe Val Pro Trp Thr                                     
1               5                                                       


<210>  20
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  20

Ser Gln Asn Thr Phe Val Pro Trp Thr 
1               5                   


<210>  21
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanised sequence


<220>
<221>  CDS
<222>  (1)..(660)

<400>  21
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat acc aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag      384
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu         
        115                 120                 125                     

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc      432
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe         
    130                 135                 140                         

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa      480
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln         
145                 150                 155                 160         

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc      528
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser         
                165                 170                 175             

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag      576
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu         
            180                 185                 190                 

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg      624
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser         
        195                 200                 205                     

ccc gtc aca aag agc ttc aac agg gga gag tgt tga                      660
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                             
    210                 215                                             


<210>  22
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  23
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanised sequence


<220>
<221>  CDS
<222>  (1)..(339)

<400>  23
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga       48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly         
1               5                   10                  15              

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt       96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser         
            20                  25                  30                  

aat acc aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct      144
Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg      192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn         
                85                  90                  95              

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgt                                                                  339
Arg                                                                     
                                                                        


<210>  24
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  25
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Humanised sequence


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  25
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gag ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  26
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  26

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  27
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Humanised sequence


<220>
<221>  CDS
<222>  (1)..(345)

<400>  27
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gag ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc                                                          345
Val Ser Ser                                                             
        115                                                             


<210>  28
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  28

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  29
<211>  18
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(18)

<400>  29
ggg gac gag ggt tat tcc                                               18
Gly Asp Glu Gly Tyr Ser                                                 
1               5                                                       


<210>  30
<211>  6
<212>  PRT
<213>  Mus sp.

<400>  30

Gly Asp Glu Gly Tyr Ser 
1               5       


<210>  31
<211>  48
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(48)

<400>  31
aga tct ggt cag agc ctt gtg cac agt aat acc aac acc tat ctg cat       48
Arg Ser Gly Gln Ser Leu Val His Ser Asn Thr Asn Thr Tyr Leu His         
1               5                   10                  15              


<210>  32
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  32

Arg Ser Gly Gln Ser Leu Val His Ser Asn Thr Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  33
<211>  1221
<212>  DNA
<213>  homo sapiens

<400>  33
atgattcaca ccaacctgaa gaaaaagttc agctgctgcg tcctggtctt tcttctgttt     60

gcagtcatct gtgtgtggaa ggaaaagaag aaagggagtt actatgattc ctttaaattg    120

caaaccaagg aattccaggt gttaaagagt ctggggaaat tggccatggg gtctgattcc    180

cagtctgtat cctcaagcag cacccaggac ccccacaggg gccgccagac cctcggcagt    240

ctcagaggcc tagccaaggc caaaccagag gcctccttcc aggtgtggaa caaggacagc    300

tcttccaaaa accttatccc taggctgcaa aagatctgga agaattacct aagcatgaac    360

aagtacaaag tgtcctacaa ggggccagga ccaggcatca agttcagtgc agaggccctg    420

cgctgccacc tccgggacca tgtgaatgta tccatggtag aggtcacaga ttttcccttc    480

aatacctctg aatgggaggg ttatctgccc aaggagagca ttaggaccaa ggctgggcct    540

tggggcaggt gtgctgttgt gtcgtcagcg ggatctctga agtcctccca actaggcaga    600

gaaatcgatg atcatgacgc agtcctgagg tttaatgggg cacccacagc caacttccaa    660

caagatgtgg gcacaaaaac taccattcgc ctgatgaact ctcagttggt taccacagag    720

aagcgcttcc tcaaagacag tttgtacaat gaaggaatcc taattgtatg ggacccatct    780

gtataccact cagatatccc aaagtggtac cagaatccgg attataattt ctttaataac    840

tacaagactt atcgtaagct gcaccccaat cagccctttt acatcctcaa gccccagatg    900

ccttgggagc tatgggacat tcttcaagaa atctccccag aagagattca gccaaacccc    960

ccatcctctg ggatgcttgg tatcatcatc atgatgacgc tgtgtgacca ggtggatatt   1020

tatgagttcc tcccatccaa gcgcaagact gacgtgtgct actactacca gaagttcttc   1080

gatagtgcct gcacgatggg tgcctaccac ccgctgctct atgagaagaa tttggtgaag   1140

catctcaacc agggcacaga tgaggacatc tacctgcttg gaaaagccac actgcctggc   1200

ttccggacca ttcactgcta a                                             1221


<210>  34
<211>  406
<212>  PRT
<213>  homo sapiens

<400>  34

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val 
1               5                   10                  15      


Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly 
            20                  25                  30          


Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu 
        35                  40                  45              


Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser 
    50                  55                  60                  


Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser 
65                  70                  75                  80  


Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp 
                85                  90                  95      


Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile 
            100                 105                 110         


Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly 
        115                 120                 125             


Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu 
    130                 135                 140                 


Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe 
145                 150                 155                 160 


Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr 
                165                 170                 175     


Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser 
            180                 185                 190         


Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val 
        195                 200                 205             


Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly 
    210                 215                 220                 


Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu 
225                 230                 235                 240 


Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val 
                245                 250                 255     


Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn 
            260                 265                 270         


Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His 
        275                 280                 285             


Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu 
    290                 295                 300                 


Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro 
305                 310                 315                 320 


Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp 
                325                 330                 335     


Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val 
            340                 345                 350         


Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala 
        355                 360                 365             


Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln 
    370                 375                 380                 


Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly 
385                 390                 395                 400 


Phe Arg Thr Ile His Cys 
                405     


<210>  35
<211>  1197
<212>  DNA
<213>  homo sapiens

<400>  35
atgaggcttc gggagccgct cctgagcggc agcgccgcga tgccaggcgc gtccctacag     60

cgggcctgcc gcctgctcgt ggccgtctgc gctctgcacc ttggcgtcac cctcgtttac    120

tacctggctg gccgcgacct gagccgcctg ccccaactgg tcggagtctc cacaccgctg    180

cagggcggct cgaacagtgc cgccgccatc gggcagtcct ccggggagct ccggaccgga    240

ggggcccggc cgccgcctcc tctaggcgcc tcctcccagc cgcgcccggg tggcgactcc    300

agcccagtcg tggattctgg ccctggcccc gctagcaact tgacctcggt cccagtgccc    360

cacaccaccg cactgtcgct gcccgcctgc cctgaggagt ccccgctgct tgtgggcccc    420

atgctgattg agtttaacat gcctgtggac ctggagctcg tggcaaagca gaacccaaat    480

gtgaagatgg gcggccgcta tgcccccagg gactgcgtct ctcctcacaa ggtggccatc    540

atcattccat tccgcaaccg gcaggagcac ctcaagtact ggctatatta tttgcatcca    600

gtcctgcagc gccagcagct ggactatggc atctatgtta tcaaccaggc gggagacact    660

atattcaatc gtgctaagct cctcaatgtt ggctttcaag aagccttgaa ggactatgac    720

tacacctgct ttgtgtttag tgacgtggac ctcattccaa tgaatgacca taatgcgtac    780

aggtgttttt cacagccacg gcacatttcc gttgcaatgg ataagtttgg attcagccta    840

ccttatgttc agtattttgg aggtgtctct gctctaagta aacaacagtt tctaaccatc    900

aatggatttc ctaataatta ttggggctgg ggaggagaag atgatgacat ttttaacaga    960

ttagttttta gaggcatgtc tatatctcgc ccaaatgctg tggtcgggag gtgtcgcatg   1020

atccgccact caagagacaa gaaaaatgaa cccaatcctc agaggtttga ccgaattgca   1080

cacacaaagg agacaatgct ctctgatggt ttgaactcac tcacctacca ggtgctggat   1140

gtacagagat acccattgta tacccaaatc acagtggaca tcgggacacc gagctag      1197


<210>  36
<211>  398
<212>  PRT
<213>  homo sapiens

<400>  36

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210>  37
<211>  1374
<212>  DNA
<213>  mus musculus

<400>  37
atggaatgca gctgggtctt tctctttctg gtagcaacag ctacaggtgt gcactcccag     60

gtccagctgc agcagtctgg gcctgagctg gtgaggcctg gggtctcagt gaagatttcc    120

tgcaagggtt ccggctacac attcactgat tatgctatgc actgggtgaa gcagagtcat    180

gcaaagagtc tagagtggat tggagttatt agtactaagt atggtaagac aaactacaac    240

cagaagttta agggcaaggc cacaatgact gttgacaaat cctccagcac agcctatatg    300

gagcttgcca gattgacatc tgaggattct gccatctatt actgtgcaag aggggacgat    360

ggttattcct ggggtcaagg aacctcagtc accgtctcct cagccaaaac gacaccccca    420

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga    480

tgcctggtca agggctattt ccctgagcca gtgacagtga cctggaactc tggatccctg    540

tccagcggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac tctgagcagc    600

tcagtgactg tcccctccag cacctggccc agcgagaccg tcacctgcaa cgttgcccac    660

ccggccagca gcaccaaggt ggacaagaaa attgtgccca gggattgtgg ttgtaagcct    720

tgcatatgta cagtcccaga agtatcatct gtcttcatct tccccccaaa gcccaaggat    780

gtgctcacca ttactctgac tcctaaggtc acgtgtgttg tggtagacat cagcaaggat    840

gatcccgagg tccagttcag ctggtttgta gatgatgtgg aggtgcacac agctcagacg    900

caaccccggg aggagcagtt caacagcact ttccgctcag tcagtgaact tcccatcatg    960

caccaggact ggctcaatgg caaggagttc aaatgcaggg tcaacagtgc agctttccct   1020

gcccccatcg agaaaaccat ctccaaaacc aaaggcagac cgaaggctcc acaggtgtac   1080

accattccac ctcccaagga gcagatggcc aaggataaag tcagtctgac ctgcatgata   1140

acagacttct tccctgaaga cattactgtg gagtggcagt ggaatgggca gccagcggag   1200

aactacaaga acactcagcc catcatggac acagatggct cttacttcgt ctacagcaag   1260

ctcaatgtgc agaagagcaa ctgggaggca ggaaatactt tcacctgctc tgtgttacat   1320

gagggcctgc acaaccacca tactgagaag agcctctccc actctcctgg ttga         1374


<210>  38
<211>  438
<212>  PRT
<213>  mus musculus

<400>  38

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
    210                 215                 220                 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
            260                 265                 270         


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
                325                 330                 335     


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
            340                 345                 350         


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
        355                 360                 365             


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
    370                 375                 380                 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
385                 390                 395                 400 


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
                405                 410                 415     


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
            420                 425                 430         


Leu Ser His Ser Pro Gly 
        435             


<210>  39
<211>  717
<212>  DNA
<213>  mus musculus

<400>  39
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat     60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc    120

tcttgcagat ctggtcagag ccttgtacac agtaatggaa acacctattt acattggtac    180

ctgcagaagc caggccagtc tccaaagctc ctgatctata cagtttccaa ccgattttct    240

ggggtcccgg acaggttcag tggcagtgga tcagggtcag atttcacact caagatcagc    300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaaatacatt tgttccttgg    360

acgttcggtg gaggcaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc    420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg    480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa    540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc    600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc    660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttaa       717


<210>  40
<211>  219
<212>  PRT
<213>  mus musculus

<400>  40

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  41
<211>  1374
<212>  DNA
<213>  mus musculus

<400>  41
atggaatgca gctgggtctt tctctttctg gtagcaacag ctacaggtgt gcactcccag     60

gtccagctgc agcagtctgg gcctgagctg gtgaggcctg gggtctcagt gaagatttcc    120

tgcaagggtt ccggctacac attcactgat tatgctatgc actgggtgaa gcagagtcat    180

gcaaagagtc tagagtggat tggagttatt agtactaagt atggtaagac aaactacaac    240

cagaagttta agggcaaggc cacaatgact gttgacaaat cctccagcac agcctatatg    300

gagcttgcca gattgacatc tgaggattct gccatctatt actgtgcaag aggggacgat    360

ggttattcct ggggtcaagg aacctcagtc accgtctcct cagccaaaac gacaccccca    420

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga    480

tgcctggtca agggctattt ccctgagcca gtgacagtga cctggaactc tggatccctg    540

tccagcggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac tctgagcagc    600

tcagtgactg tcccctccag cacctggccc agcgagaccg tcacctgcaa cgttgcccac    660

ccggccagca gcaccaaggt ggacaagaaa attgtgccca gggattgtgg ttgtaagcct    720

tgcatatgta cagtcccaga agtatcatct gtcttcatcg cccccccaaa gcccaaggat    780

gtgctcacca ttactctgac tcctaaggtc acgtgtgttg tggtagacat cagcaaggat    840

gatcccgagg tccagttcag ctggtttgta gatgatgtgg aggtgcacac agctcagacg    900

caaccccggg aggagcagtt caacagcact ttccgctcag tcagtgaact tcccatcatg    960

caccaggact ggctcaatgg caaggagttc aaatgcaggg tcaacagtgc agctttccct   1020

gcccccatcg agaaaaccat ctccaaaacc aaaggcagac cgaaggctcc acaggtgtac   1080

accattccac ctcccaagga gcagatggcc aaggataaag tcagtctgac ctgcatgata   1140

acagacttct tccctgaaga cattactgtg gagtggcagt ggaatgggca gccagcggag   1200

aactacaaga acactcagcc catcatggac acagatggct cttacttcgt ctacagcaag   1260

ctcaatgtgc agaagagcaa ctgggaggca ggaaatactt tcacctgctc tgtgttacat   1320

gagggcctgc acaaccacca tactgagaag agcctctccc actctcctgg ttga         1374


<210>  42
<211>  438
<212>  PRT
<213>  mus musculus

<400>  42

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
    210                 215                 220                 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Ala Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
            260                 265                 270         


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
                325                 330                 335     


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
            340                 345                 350         


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
        355                 360                 365             


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
    370                 375                 380                 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
385                 390                 395                 400 


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
                405                 410                 415     


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
            420                 425                 430         


Leu Ser His Ser Pro Gly 
        435             


<210>  43
<211>  1374
<212>  DNA
<213>  mus musculus

<400>  43
atggaatgca gctgggtctt tctctttctg gtagcaacag ctacaggtgt gcactcccag     60

gtccagctgc agcagtctgg gcctgagctg gtgaggcctg gggtctcagt gaagatttcc    120

tgcaagggtt ccggctacac attcactgat tatgctatgc actgggtgaa gcagagtcat    180

gcaaagagtc tagagtggat tggagttatt agtactaagt atggtaagac aaactacaac    240

cagaagttta agggcaaggc cacaatgact gttgacaaat cctccagcac agcctatatg    300

gagcttgcca gattgacatc tgaggattct gccatctatt actgtgcaag aggggacgat    360

ggttattcct ggggtcaagg aacctcagtc accgtctcct cagccaaaac gacaccccca    420

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga    480

tgcctggtca agggctattt ccctgagcca gtgacagtga cctggaactc tggatccctg    540

tccagcggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac tctgagcagc    600

tcagtgactg tcccctccag cacctggccc agcgagaccg tcacctgcaa cgttgcccac    660

ccggccagca gcaccaaggt ggacaagaaa attgtgccca gggattgtgg ttgtaagcct    720

tgcatatgta cagtcccaga agtatcatct gtcttcatct tccccccaaa gcccaaggat    780

gtgctcacca ttactctgac tcctaaggtc acgtgtgttg tggcagacat cagcaaggat    840

gatcccgagg tccagttcag ctggtttgta gatgatgtgg aggtgcacac agctcagacg    900

caaccccggg aggagcagtt caacagcact ttccgctcag tcagtgaact tcccatcatg    960

caccaggact ggctcaatgg caaggagttc aaatgcaggg tcaacagtgc agctttccct   1020

gcccccatcg agaaaaccat ctccaaaacc aaaggcagac cgaaggctcc acaggtgtac   1080

accattccac ctcccaagga gcagatggcc aaggataaag tcagtctgac ctgcatgata   1140

acagacttct tccctgaaga cattactgtg gagtggcagt ggaatgggca gccagcggag   1200

aactacaaga acactcagcc catcatggac acagatggct cttacttcgt ctacagcaag   1260

ctcaatgtgc agaagagcaa ctgggaggca ggaaatactt tcacctgctc tgtgttacat   1320

gagggcctgc acaaccacca tactgagaag agcctctccc actctcctgg ttga         1374


<210>  44
<211>  438
<212>  PRT
<213>  mus musculus

<400>  44

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
    210                 215                 220                 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Ala 
                245                 250                 255     


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
            260                 265                 270         


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
                325                 330                 335     


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
            340                 345                 350         


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
        355                 360                 365             


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
    370                 375                 380                 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
385                 390                 395                 400 


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
                405                 410                 415     


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
            420                 425                 430         


Leu Ser His Ser Pro Gly 
        435             


<210>  45
<211>  1374
<212>  DNA
<213>  mus musculus

<400>  45
atggaatgca gctgggtctt tctctttctg gtagcaacag ctacaggtgt gcactcccag     60

gtccagctgc agcagtctgg gcctgagctg gtgaggcctg gggtctcagt gaagatttcc    120

tgcaagggtt ccggctacac attcactgat tatgctatgc actgggtgaa gcagagtcat    180

gcaaagagtc tagagtggat tggagttatt agtactaagt atggtaagac aaactacaac    240

cagaagttta agggcaaggc cacaatgact gttgacaaat cctccagcac agcctatatg    300

gagcttgcca gattgacatc tgaggattct gccatctatt actgtgcaag aggggacgat    360

ggttattcct ggggtcaagg aacctcagtc accgtctcct cagccaaaac gacaccccca    420

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga    480

tgcctggtca agggctattt ccctgagcca gtgacagtga cctggaactc tggatccctg    540

tccagcggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac tctgagcagc    600

tcagtgactg tcccctccag cacctggccc agcgagaccg tcacctgcaa cgttgcccac    660

ccggccagca gcaccaaggt ggacaagaaa attgtgccca gggattgtgg ttgtaagcct    720

tgcatatgta cagtcccaga agtatcatct gtcttcatct tccccccaaa gcccaaggat    780

gtgctcacca ttactctgac tcctaaggtc acgtgtgttg tggtagccat cagcaaggat    840

gatcccgagg tccagttcag ctggtttgta gatgatgtgg aggtgcacac agctcagacg    900

caaccccggg aggagcagtt caacagcact ttccgctcag tcagtgaact tcccatcatg    960

caccaggact ggctcaatgg caaggagttc aaatgcaggg tcaacagtgc agctttccct   1020

gcccccatcg agaaaaccat ctccaaaacc aaaggcagac cgaaggctcc acaggtgtac   1080

accattccac ctcccaagga gcagatggcc aaggataaag tcagtctgac ctgcatgata   1140

acagacttct tccctgaaga cattactgtg gagtggcagt ggaatgggca gccagcggag   1200

aactacaaga acactcagcc catcatggac acagatggct cttacttcgt ctacagcaag   1260

ctcaatgtgc agaagagcaa ctgggaggca ggaaatactt tcacctgctc tgtgttacat   1320

gagggcctgc acaaccacca tactgagaag agcctctccc actctcctgg ttga         1374


<210>  46
<211>  438
<212>  PRT
<213>  mus musculus

<400>  46

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
    210                 215                 220                 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
                245                 250                 255     


Ala Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
            260                 265                 270         


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
                325                 330                 335     


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
            340                 345                 350         


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
        355                 360                 365             


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
    370                 375                 380                 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
385                 390                 395                 400 


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
                405                 410                 415     


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
            420                 425                 430         


Leu Ser His Ser Pro Gly 
        435             


<210>  47
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  HC of humanized antiAbeta_13C13_ IgG4_D260A mAb


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  47
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg gcc gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  48
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  48

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  49
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  HC of humanized antiAbeta_13C13_ IgG4_D260G mAb


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  49
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg ggc gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Gly Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  50
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Gly Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  51
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  HC of humanized antiAbeta_13C13_IgG4_D260L mAb


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  51
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg ctg gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Leu Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  52
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  52

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Leu Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  53
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  HC of humanized antiAbeta_13C13_IgG4_D260K mAb


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  53
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg aag gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Lys Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  54
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  54

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Lys Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  55
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  HC of humanized antiAbeta_13C13_IgG4_D260S mAb for expression


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  55
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val         
1               5                   10                  15              

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat       96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr         
            20                  25                  30                  

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att      144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt      192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe         
    50                  55                  60                          

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat      240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt      288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys         
                85                  90                  95              

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc      336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr         
            100                 105                 110                 

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct      384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro         
        115                 120                 125                     

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg      432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val         
    130                 135                 140                         

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc      480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala         
145                 150                 155                 160         

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc      528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly         
                165                 170                 175             

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc      576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly         
            180                 185                 190                 

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag      624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys         
        195                 200                 205                     

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc      672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys         
    210                 215                 220                         

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct      720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
225                 230                 235                 240         

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt      768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
                245                 250                 255             

gtg gtg gtg agc gtg tcc cag gag gac cct gag gtc cag ttc aac tgg      816
Val Val Val Ser Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp         
            260                 265                 270                 

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag      864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
        275                 280                 285                     

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg      912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
    290                 295                 300                         

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac      960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
305                 310                 315                 320         

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc     1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
                325                 330                 335             

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag     1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu         
            340                 345                 350                 

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac     1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
        355                 360                 365                     

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac     1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
    370                 375                 380                         

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc     1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
385                 390                 395                 400         

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac     1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn         
                405                 410                 415             

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc     1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
            420                 425                 430                 

cag aag tcc ctg tcc ctg tct ctg ggc tga                             1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                     
        435                 440                                         


<210>  56
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  56

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Ser Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  57
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  58
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Trp Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Cys Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  59
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  60
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  60

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  61
<211>  324
<212>  PRT
<213>  Mus musculus

<400>  61

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  62
<211>  330
<212>  PRT
<213>  Mus musculus

<400>  62

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210>  63
<211>  330
<212>  PRT
<213>  Mus musculus

<400>  63

Ala Thr Thr Thr Ala Pro Ser Val Tyr Pro Leu Val Pro Gly Cys Ser 
1               5                   10                  15      


Asp Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Lys Trp Asn Tyr Gly Ala Leu Ser Ser 
        35                  40                  45              


Gly Val Arg Thr Val Ser Ser Val Leu Gln Ser Gly Phe Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Leu Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 
65                  70                  75                  80  


Ile Cys Asn Val Ala His Pro Ala Ser Lys Thr Glu Leu Ile Lys Arg 
                85                  90                  95      


Ile Glu Pro Arg Ile Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Cys 
            100                 105                 110         


Pro Pro Gly Asn Ile Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Ala Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val His Val Ser Trp 
145                 150                 155                 160 


Phe Val Asp Asn Lys Glu Val His Thr Ala Trp Thr Gln Pro Arg Glu 
                165                 170                 175     


Ala Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Arg Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Arg Ala Gln Thr Pro Gln Val Tyr Thr Ile Pro Pro Pro Arg Glu Gln 
225                 230                 235                 240 


Met Ser Lys Lys Lys Val Ser Leu Thr Cys Leu Val Thr Asn Phe Phe 
                245                 250                 255     


Ser Glu Ala Ile Ser Val Glu Trp Glu Arg Asn Gly Glu Leu Glu Gln 
            260                 265                 270         


Asp Tyr Lys Asn Thr Pro Pro Ile Leu Asp Ser Asp Gly Thr Tyr Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Thr Asp Ser Trp Leu Gln Gly Glu 
    290                 295                 300                 


Ile Phe Thr Cys Ser Val Val His Glu Ala Leu His Asn His His Thr 
305                 310                 315                 320 


Gln Lys Asn Leu Ser Arg Ser Pro Gly Lys 
                325                 330 


