                         SEQUENCE LISTING

<110>  Cepep III AB
       University of Tartu
 
<120>  A system for gargo delivery into the cells

<130>  209/P17-EP

<140>  EP11155275.8
<141>  2011-02-22

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide TP10, description page 5, rows 3-4

<300>
<301>  Ursel Soomets, Maria Lindgren, Xavier Gallet, Mattias Hllbrink, 
       Anna Elmquist, Lajos Balaspiri, Matjaz Zorko, Margus Pooga, 
       Robert Brasseur, lo Langel
<302>  Deletion analogues of transportan
<303>  Biochimica et Biophysica Acta
<304>  1467
<305>  1
<306>  165-176
<307>  2000-07-31

<400>  1

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  2
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 1 sequence, Table 2 page 9,

<400>  2

Ala Gly Tyr Leu Leu Gly Lys Thr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 2 sequence, Table 2 page 9

<400>  3

Ala Gly Tyr Leu Leu Gly Lys Thr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 3 sequence, Table 2 page 9

<400>  4

Ala Gly Tyr Leu Leu Gly Lys Thr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 4 sequence, Table 2 page 9

<400>  5

Ala Gly Tyr Leu Leu Gly Lys Thr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 5 sequence, Table 2 page 9

<400>  6

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 6 sequence, Table 2 page 9

<400>  7

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 7 sequence, Table 2 page 9

<400>  8

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 11 sequence, Table 2 page 9

<400>  9

Ala Gly Tyr Leu Leu Gly Lys Thr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 12 sequence, Table 2 page 9

<400>  10

Ala Gly Tyr Leu Leu Gly Lys Ser Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 13 sequence, Table 2 page 9

<400>  11

Ala Gly Tyr Leu Leu Gly Lys Tyr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 14 sequence, Table 2 page 9

<400>  12

Ala Gly Asp Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 15 sequence, Table 2 page 9

<400>  13

Ala Gly Glu Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 21 sequence, Table 2 page 9

<400>  14

Ala Gly Tyr Leu Leu Gly Lys Thr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  15
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 23 sequence, Table 2 page 9

<400>  15

Ala Gly Tyr Leu Leu Gly Lys Ser Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 23 sequence, Table 2 page 9

<400>  16

Ala Gly Tyr Leu Leu Gly Lys Tyr Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 24 sequence, Table 2 page 9

<400>  17

Ala Gly Asp Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 25 sequence, Table 2 page 9

<400>  18

Ala Gly Glu Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 31 sequence, Table 2 page 9, Glu Glu linked to 
       position 3

<400>  19

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  20
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 32 sequence, Table 2 page 9, Asp Asp linked to 
       position 3

<400>  20

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 33 sequence, Table 2 page 9, Asp Glu linked to 
       position 3

<400>  21

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  22
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 34 sequence, Table 2 page 9, Glu Glu linked to 
       position 7

<400>  22

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  23
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 35 sequence, Table 2 page 9, Asp Asp linked to 
       position 7

<400>  23

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  24
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 36 sequence, Table 2 page 9, Asp Glu linked to 
       position 7

<400>  24

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 37 sequence, Table 2 page 9, Glu Glu linked to 
       position 3


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Orn

<400>  25

Ala Gly Xaa Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  26
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 38 sequence, Table 2 page 9, Asp Asp linked to 
       position 3


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Orn

<400>  26

Ala Gly Xaa Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 39 sequence, Table 2 page 10, Glu Asp linked to
       position 3


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Orn

<400>  27

Ala Gly Xaa Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 41 sequence, Table 2 page 10, Glu Glu linked to
       position 3

<400>  28

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 42 sequence, Table 2 page 10, Asp Asp linked to
       position 3

<400>  29

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 43 sequence, Table 2 page 10, Asp Glu linked to
       position 3

<400>  30

Ala Gly Lys Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 51 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Orn

<400>  31

Ala Gly Tyr Leu Leu Gly Xaa Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  32
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 52 sequence, Table 2 page 10

<400>  32

Ala Gly Tyr Leu Leu Gly Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 53 sequence, Table 2 page 10

<400>  33

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  34
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 54 sequence, Table 2 page 10,

<400>  34

Arg Pro Pro Gly Phe Ser Pro Phe Arg Ala Gly Tyr Leu Leu Gly Lys 
1               5                   10                  15      


Ile Asn Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25                  30  


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 55 sequence, Table 2 page 10

<400>  35

Ala Leu Ala Leu Leu Leu Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  36
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 56 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Orn

<400>  36

Arg Pro Lys Pro Gln Gln Phe Gly Leu Met Ala Gly Tyr Leu Leu Gly 
1               5                   10                  15      


Xaa Ile Asn Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25                  30      


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 43 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (18)..(19)
<223>  Orn

<400>  37

Ala Gly Tyr Leu Leu Gly Xaa Ile Asn Leu Xaa Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Xaa Xaa Ile Leu 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 71 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Orn

<400>  38

Ala Gly Tyr Leu Leu Gly Xaa Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 72 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Orn

<400>  39

Ala Gly Tyr Leu Leu Gly Xaa Ile Asn Leu Xaa Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 73 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Orn

<400>  40

Ala Gly Tyr Leu Leu Gly Xaa Ile Asn Leu Xaa Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Xaa Lys Ile Leu 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 74 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (18)..(19)
<223>  Orn

<400>  41

Ala Gly Tyr Leu Leu Gly Xaa Ile Asn Leu Xaa Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Xaa Xaa Ile Leu 
            20      


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 81 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Nle

<400>  42

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Xaa Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 82 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Nle

<400>  43

Ala Gly Tyr Leu Xaa Gly Lys Ile Asn Xaa Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 83 sequence, Table 2 page 10


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Nle

<400>  44

Ala Gly Tyr Leu Xaa Gly Lys Ile Asn Xaa Lys Ala Xaa Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  45
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 91 sequence, Table 2 page 10, Asp Asp linked to
       position 1

<400>  45

Lys Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala 
1               5                   10                  15      


Leu Ala Lys Lys Ile Leu 
            20          


<210>  46
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 92 sequence, Table 2 page 10, Glu Glu linked to
       position 1

<400>  46

Lys Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala 
1               5                   10                  15      


Leu Ala Lys Lys Ile Leu 
            20          


<210>  47
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 93 sequence, Table 2 page 10, Asp Glu linked to
       position 1

<400>  47

Lys Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala 
1               5                   10                  15      


Leu Ala Lys Lys Ile Leu 
            20          


<210>  48
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 94 sequence, Table 2 page 10, Asp linked to 
       position 1

<400>  48

Lys Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala 
1               5                   10                  15      


Leu Ala Lys Lys Ile Leu 
            20          


<210>  49
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, NickFect 95 sequence, Table 2 page 10, Asp Asp linked to
       position 1


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Orn

<400>  49

Xaa Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala 
1               5                   10                  15      


Leu Ala Lys Lys Ile Leu 
            20          


<210>  50
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA oligonucleotide, page 11, Microsynth AG, Switzerland

<400>  50
ccucuuaccu caguuaca                                                     18


