                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Antibodies against human IL33R and uses thereof

<130>  27240 FT

<150>  EP11155684
<151>  2011-02-23

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1

Asp Gln Tyr Arg Ser Ser Gly Val Ser Asp Tyr Asp Ile 
1               5                   10              


<210>  2
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  2

Tyr Ile Trp Ser Asp Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  3
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Ser His Asp Met Ser 
1               5   


<210>  4
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Leu Gly Gly Tyr Asp Asp Asp Ala Asp Asn Thr 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  6
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Gln Ser Ser Gln Ser Val Gly Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  7
<211>  118
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser His Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Tyr Ile Trp Ser Asp Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Gln 
                85                  90                  95      


Tyr Arg Ser Ser Gly Val Ser Asp Tyr Asp Ile Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8
<211>  111
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Gly Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Ile 
        35                  40                  45              


Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Glu Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Ala Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  9
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  10
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  12

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  13
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Replaced ST2 sequence fragment 1 for mut1

<400>  13

Asp Tyr Leu Met Tyr Ser Thr Val Ser 
1               5                   


<210>  14
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Replaced ST2 sequence fragment 2 for mut1

<400>  14

Ser Glu Lys Asn Ser Lys Ile Tyr 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Replaced ST2 sequence fragment 3 for mut1

<400>  15

Arg Ala His Lys Ser Phe Leu Val 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Replaced ST2 sequence fragment 4 for mut1

<400>  16

Leu Ala Ala Val Leu Trp Gln Leu 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  IL-1R fragment 1 mut1, replacing ST2 fragment SEQ13

<400>  17

Ala Gln Ala Ile Phe Lys Gln Lys Leu 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  IL-1R fragment 2 mut2, replacing ST2 fragment SEQ14

<400>  18

Val Ala Gly Asp Gly Gly Leu Val 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  IL-1R fragment 3 mut3, replacing ST2 fragment SEQ15

<400>  19

Ser Gly Val Lys Asp Arg Leu Ile 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  IL-1R fragment 4 mut4, replacing ST2 fragment SEQ16

<400>  20

Ser Asp Ile Ala Tyr Trp Lys Trp 
1               5               


<210>  21
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable domain, humanized ra170 11.12(VH11)

<400>  21

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Ser Ser His Asp 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Trp Ser Asp Glu Ser Thr Tyr Tyr Ala Ser Trp Ala Gln Gly 
    50                  55                  60                  


Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Gln Tyr Arg Ser Ser Gly Val Ser Asp Tyr Asp Ile Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDR1, Mab ra170 11.12

<400>  22

Ser His Asp Ile Ser 
1               5   


<210>  23
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDR2, Mab ra170 11.12

<400>  23

Tyr Ile Trp Ser Asp Glu Ser Thr Tyr Tyr Ala Ser Trp Ala Gln Gly 
1               5                   10                  15      


<210>  24
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDR3, Mab ra170 11.12

<400>  24

Asp Gln Tyr Arg Ser Ser Gly Val Ser Asp Tyr Asp Ile 
1               5                   10              


<210>  25
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable domain, humanized ra170 10.12(VH10)

<400>  25

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Ser Ser His Asp 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Trp Ser Asp Glu Asn Thr Tyr Tyr Ala Ser Trp Ala Gln Gly 
    50                  55                  60                  


Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Gln Tyr Arg Ser Ser Gly Val Ser Asp Tyr Asp Ile Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDR1, Mab ra170 10.12

<400>  26

Ser His Asp Ile Ser 
1               5   


<210>  27
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDR2, Mab ra170 10.12

<400>  27

Tyr Ile Trp Ser Asp Glu Asn Thr Tyr Tyr Ala Ser Trp Ala Gln Gly 
1               5                   10                  15      


<210>  28
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDR3, Mab ra170 10.12

<400>  28

Asp Gln Tyr Arg Ser Ser Gly Val Ser Asp Tyr Asp Ile 
1               5                   10              


<210>  29
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  30
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  light chain variable domain, humanized ra170 (11.12 and 10.12)

<400>  30

Ala Ala Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Val Gly Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Lys Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Ala Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  31
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDR1, Mab ra170 10.12 and 11.12

<400>  31

Arg Ser Ser Gln Ser Val Gly Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  32
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDR2, Mab ra170 10.12 and 11.12

<400>  32

Lys Ala Ser Thr Arg Ala Thr 
1               5           


<210>  33
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDR3, Mab ra170 10.12 and 11.12

<400>  33

Leu Gly Gly Tyr Asp Asp Asp Ala Asp Asn Thr 
1               5                   10      


<210>  34
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  34

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


