                         SEQUENCE LISTING

<110>  Fibrostatin S.L., et al. 
 
<120>  Methods for treating and diagnosing disease

<130>  150-297

<150>  61/444872
<151>  2011-02-21

<150>  61/469945
<151>  2011-03-31

<150>  61/473411
<151>  2011-04-08

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Asp Asn Gln Ser Trp Asn Ser Ser Gly Ser Glu Glu Asp Pro 
1               5                   10                  15      


Glu Thr Glu Ser Gly Pro Pro Val Glu Arg Cys Gly Val Leu Ser Lys 
            20                  25                  30          


Trp Thr Asn Tyr Ile His Gly Trp Gln Asp Arg Trp Val Val Leu Lys 
        35                  40                  45              


Asn Asn Ala Leu Ser Tyr Tyr Lys Ser Glu Asp Glu Thr Glu Tyr Gly 
    50                  55                  60                  


Cys Arg Gly Ser Ile Cys Leu Ser Lys Ala Val Ile Thr Pro His Asp 
65                  70                  75                  80  


Phe Asp Glu Cys Arg Phe Asp Ile Ser Val Asn Asp Ser Val Trp Tyr 
                85                  90                  95      


Leu Arg Ala Gln Asp Pro Asp His Arg Gln Gln Trp Ile Asp Ala Ile 
            100                 105                 110         


Glu Gln His Lys Thr Glu Ser Gly Tyr Gly Ser Glu Ser Ser Leu Arg 
        115                 120                 125             


Arg His Gly Ser Met Val Ser Leu Val Ser Gly Ala Ser Gly Tyr Ser 
    130                 135                 140                 


Ala Thr Ser Thr Ser Ser Phe Lys Lys Gly His Ser Leu Arg Glu Lys 
145                 150                 155                 160 


Leu Ala Glu Met Glu Thr Phe Arg Asp Ile Leu Cys Arg Gln Val Asp 
                165                 170                 175     


Thr Leu Gln Lys Tyr Phe Asp Ala Cys Ala Asp Ala Val Ser Lys Asp 
            180                 185                 190         


Glu Leu Gln Arg Asp Lys Val Val Glu Asp Asp Glu Asp Asp Phe Pro 
        195                 200                 205             


Thr Thr Arg Ser Asp Gly Asp Phe Leu His Ser Thr Asn Gly Asn Lys 
    210                 215                 220                 


Glu Lys Leu Phe Pro His Val Thr Pro Lys Gly Ile Asn Gly Ile Asp 
225                 230                 235                 240 


Phe Lys Gly Glu Ala Ile Thr Phe Lys Ala Thr Thr Ala Gly Ile Leu 
                245                 250                 255     


Ala Thr Leu Ser His Cys Ile Glu Leu Met Val Lys Arg Glu Asp Ser 
            260                 265                 270         


Trp Gln Lys Arg Leu Asp Lys Glu Thr Glu Lys Lys Arg Arg Thr Glu 
        275                 280                 285             


Glu Ala Tyr Lys Asn Ala Met Thr Glu Leu Lys Lys Lys Ser His Phe 
    290                 295                 300                 


Gly Gly Pro Asp Tyr Glu Glu Gly Pro Asn Ser Leu Ile Asn Glu Glu 
305                 310                 315                 320 


Glu Phe Phe Asp Ala Val Glu Ala Ala Leu Asp Arg Gln Asp Lys Ile 
                325                 330                 335     


Glu Glu Gln Ser Gln Ser Glu Lys Val Arg Leu His Trp Pro Thr Ser 
            340                 345                 350         


Leu Pro Ser Gly Asp Ala Phe Ser Ser Val Gly Thr His Arg Phe Val 
        355                 360                 365             


Gln Lys Pro Tyr Ser Arg Ser Ser Ser Met Ser Ser Ile Asp Leu Val 
    370                 375                 380                 


Ser Ala Ser Asp Asp Val His Arg Phe Ser Ser Gln Val Glu Glu Met 
385                 390                 395                 400 


Val Gln Asn His Met Thr Tyr Ser Leu Gln Asp Val Gly Gly Asp Ala 
                405                 410                 415     


Asn Trp Gln Leu Val Val Glu Glu Gly Glu Met Lys Val Tyr Arg Arg 
            420                 425                 430         


Glu Val Glu Glu Asn Gly Ile Val Leu Asp Pro Leu Lys Ala Thr His 
        435                 440                 445             


Ala Val Lys Gly Val Thr Gly His Glu Val Cys Asn Tyr Phe Trp Asn 
    450                 455                 460                 


Val Asp Val Arg Asn Asp Trp Glu Thr Thr Ile Glu Asn Phe His Val 
465                 470                 475                 480 


Val Glu Thr Leu Ala Asp Asn Ala Ile Ile Ile Tyr Gln Thr His Lys 
                485                 490                 495     


Arg Val Trp Pro Ala Ser Gln Arg Asp Val Leu Tyr Leu Ser Val Ile 
            500                 505                 510         


Arg Lys Ile Pro Ala Leu Thr Glu Asn Asp Pro Glu Thr Trp Ile Val 
        515                 520                 525             


Cys Asn Phe Ser Val Asp His Asp Ser Ala Pro Leu Asn Asn Arg Cys 
    530                 535                 540                 


Val Arg Ala Lys Ile Asn Val Ala Met Ile Cys Gln Thr Leu Val Ser 
545                 550                 555                 560 


Pro Pro Glu Gly Asn Gln Glu Ile Ser Arg Asp Asn Ile Leu Cys Lys 
                565                 570                 575     


Ile Thr Tyr Val Ala Asn Val Asn Pro Gly Gly Trp Ala Pro Ala Ser 
            580                 585                 590         


Val Leu Arg Ala Val Ala Lys Arg Glu Tyr Pro Lys Phe Leu Lys Arg 
        595                 600                 605             


Phe Thr Ser Tyr Val Gln Glu Lys Thr Ala Gly Lys Pro Ile Leu Phe 
    610                 615                 620                 


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Optionally absent

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (16)..(25)
<223>  Optionally Absent

<400>  2

Ala Thr Thr Ala Gly Ile Leu Ala Thr Leu Ser His Cys Ile Xaa Leu 
1               5                   10                  15      


Met Val Lys Arg Glu Asp Ser Trp Gln 
            20                  25  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Thr Thr Ala Gly Ile Leu Ala Thr Leu 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Leu Met Val Lys Arg Glu Asp Ser Trp Gln 
1               5                   10  


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Ser His Cys Ile Glu 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ser His Cys Ile Gln 
1               5   


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ile Leu Ala Thr Leu Ser His Cys Ile Glu Leu Met Val Lys Arg 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ile Leu Ala Thr Leu Ser His Cys Ile Gln Leu Met Val Lys Arg 
1               5                   10                  15  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Glu Lys Thr Ala Gly Lys Pro Ile Leu Phe 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Glu Lys Thr Ala Gly Lys Pro Ile Leu Phe 
1               5                   10  


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gccctatagt cgctcttcc                                                    19


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
tcctgctggt gagaaaggat                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
ctggagtccc ataacgacct                                                   20


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gctgttgaag ctgctcttga ca                                                22


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
cctgggagct gaatctgtga a                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gtaacccgtt gaaccccatt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gcgatgatgg ctaacctacc                                                   20


<210>  18
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu Lys Met Asp Leu Ala 
1               5                   10                  15      


Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro Lys Lys Val Leu Glu 
            20                  25                  30          


Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser Thr Pro Trp Gln Glu 
        35                  40                  45              


Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp Lys Val Val Glu Lys 
    50                  55                  60                  


His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln Leu Leu Val Ala Glu 
65                  70                  75                  80  


Lys Ser Arg Arg Gln Thr Ile Leu Glu Leu Glu Glu Glu Lys Arg Lys 
                85                  90                  95      


His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe Ile Cys Leu Leu Glu 
            100                 105                 110         


Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp Gln Glu Ile Lys Ser 
        115                 120                 125             


Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg Val Thr Thr Leu Lys 
    130                 135                 140                 


Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu Met Val Val Asp Glu 
145                 150                 155                 160 


Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln Arg Gln Lys Ile Gln 
                165                 170                 175     


Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr Lys Leu Ala Leu Ala 
            180                 185                 190         


Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala Thr Arg Leu Glu Lys 
        195                 200                 205             


Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln Asp Gln Asp Thr Ile 
    210                 215                 220                 


Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn Arg Gln Leu Gln Gln 
225                 230                 235                 240 


Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu Leu Glu Glu Thr Asn 
                245                 250                 255     


Arg Ser Leu Arg Lys Ala Glu Glu Glu 
            260                 265 


<210>  19
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      


Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          


His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              


Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  


Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  


Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      


Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         


Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             


Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 


Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 


Leu Leu Val Ala Glu Lys Ser Arg Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     


Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         


Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             


Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 


Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 


Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     


Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         


Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             


Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 


Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 


Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     


Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         


Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             


Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 


Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 


Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     


Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         


Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             


Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 


Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 


Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     


Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         


Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             


Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 


Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 


Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     


Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         


Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             


Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 


Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 


Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     


Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         


Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             


Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 


Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 


Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     


Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Thr Lys Ser 
            740                 745                 750         


Thr Arg Lys Gln Glu Gln Arg Phe Arg Lys Arg Asp 
        755                 760                 


<210>  20
<211>  1135
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      


Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          


His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              


Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  


Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  


Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      


Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         


Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             


Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 


Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 


Leu Leu Val Ala Glu Lys Ser Arg Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     


Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         


Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             


Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 


Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 


Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     


Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         


Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             


Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 


Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 


Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     


Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         


Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             


Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 


Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 


Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     


Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         


Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             


Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 


Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 


Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     


Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         


Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             


Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 


Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 


Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     


Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         


Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             


Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 


Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 


Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     


Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         


Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             


Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 


Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 


Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     


Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            740                 745                 750         


Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        755                 760                 765             


Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    770                 775                 780                 


Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
785                 790                 795                 800 


Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                805                 810                 815     


Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            820                 825                 830         


Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        835                 840                 845             


Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    850                 855                 860                 


Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
865                 870                 875                 880 


Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                885                 890                 895     


Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            900                 905                 910         


Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        915                 920                 925             


Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    930                 935                 940                 


Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
945                 950                 955                 960 


Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                965                 970                 975     


Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            980                 985                 990         


Leu Thr Pro Glu Arg Thr Met Ser  Pro Ile Gln Val Leu  Ala Val Thr 
        995                 1000                 1005             


Gly Ser  Ala Ser Ser Pro Glu  Gln Gly Arg Ser Pro  Glu Pro Thr 
    1010                 1015                 1020             


Glu Ile  Ser Ala Lys His Ala  Ile Phe Arg Val Ser  Pro Asp Arg 
    1025                 1030                 1035             


Gln Ser  Ser Trp Gln Phe Gln  Arg Ser Asn Ser Asn  Ser Ser Ser 
    1040                 1045                 1050             


Val Ile  Thr Thr Glu Asp Asn  Lys Ile His Ile His  Leu Gly Ser 
    1055                 1060                 1065             


Pro Tyr  Met Gln Ala Val Ala  Ser Pro Val Arg Pro  Ala Ser Pro 
    1070                 1075                 1080             


Ser Ala  Pro Leu Gln Asp Asn  Arg Thr Gln Gly Leu  Ile Asn Gly 
    1085                 1090                 1095             


Ala Leu  Asn Lys Thr Thr Asn  Lys Val Thr Ser Ser  Ile Thr Ile 
    1100                 1105                 1110             


Thr Pro  Thr Ala Thr Pro Leu  Pro Arg Gln Ser Gln  Ile Thr Val 
    1115                 1120                 1125             


Glu Pro  Leu Leu Leu Pro His  
    1130                 1135 


<210>  21
<211>  1133
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      


Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          


His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              


Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  


Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  


Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      


Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         


Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             


Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 


Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 


Leu Leu Val Ala Glu Lys Ser His Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     


Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         


Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             


Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 


Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 


Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     


Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         


Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             


Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 


Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 


Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     


Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         


Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             


Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 


Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 


Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     


Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         


Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             


Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 


Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 


Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     


Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         


Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             


Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 


Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 


Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     


Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         


Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             


Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 


Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 


Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     


Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         


Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             


Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 


Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 


Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     


Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            740                 745                 750         


Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        755                 760                 765             


Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    770                 775                 780                 


Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
785                 790                 795                 800 


Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                805                 810                 815     


Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            820                 825                 830         


Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        835                 840                 845             


Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    850                 855                 860                 


Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
865                 870                 875                 880 


Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                885                 890                 895     


Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            900                 905                 910         


Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        915                 920                 925             


Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    930                 935                 940                 


Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
945                 950                 955                 960 


Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                965                 970                 975     


Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            980                 985                 990         


Leu Thr Pro Glu Arg Thr Met Ser  Pro Ile Gln Val Leu  Ala Val Thr 
        995                 1000                 1005             


Gly Ser  Ala Ser Ser Pro Glu  Gln Gly Arg Ser Pro  Glu Pro Thr 
    1010                 1015                 1020             


Glu Ile  Ser Ala Lys His Ala  Ile Phe Arg Val Ser  Pro Asp Arg 
    1025                 1030                 1035             


Gln Ser  Ser Trp Gln Phe Gln  Arg Ser Asn Ser Asn  Ser Ser Ser 
    1040                 1045                 1050             


Val Ile  Thr Thr Glu Asp Asn  Lys Ile His Ile His  Leu Gly Ser 
    1055                 1060                 1065             


Pro Tyr  Met Gln Ala Val Ala  Ser Pro Val Arg Pro  Ala Ser Pro 
    1070                 1075                 1080             


Ser Ala  Pro Leu Gln Asp Asn  Arg Thr Gln Gly Leu  Ile Asn Gly 
    1085                 1090                 1095             


Ala Leu  Asn Lys Thr Thr Asn  Lys Val Thr Ser Ser  Ile Thr Ile 
    1100                 1105                 1110             


Thr Pro  Thr Ala Thr Pro Leu  Pro Arg Gln Ser Gln  Ile Thr Val 
    1115                 1120                 1125             


Ser Asn  Ile Tyr Asn 
    1130             


<210>  22
<211>  1133
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      


Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          


His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              


Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  


Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  


Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      


Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         


Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             


Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 


Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 


Leu Leu Val Ala Glu Lys Ser Arg Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     


Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         


Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             


Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 


Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 


Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     


Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         


Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             


Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 


Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 


Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     


Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         


Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             


Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 


Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 


Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     


Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         


Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             


Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 


Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 


Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     


Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         


Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             


Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 


Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 


Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     


Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         


Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             


Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 


Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 


Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     


Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         


Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             


Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 


Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 


Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     


Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            740                 745                 750         


Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        755                 760                 765             


Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    770                 775                 780                 


Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
785                 790                 795                 800 


Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                805                 810                 815     


Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            820                 825                 830         


Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        835                 840                 845             


Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    850                 855                 860                 


Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
865                 870                 875                 880 


Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                885                 890                 895     


Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            900                 905                 910         


Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        915                 920                 925             


Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    930                 935                 940                 


Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
945                 950                 955                 960 


Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                965                 970                 975     


Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            980                 985                 990         


Leu Thr Pro Glu Arg Thr Met Ser  Pro Ile Gln Val Leu  Ala Val Thr 
        995                 1000                 1005             


Gly Ser  Ala Ser Ser Pro Glu  Gln Gly Arg Ser Pro  Glu Pro Thr 
    1010                 1015                 1020             


Glu Ile  Ser Ala Lys His Ala  Ile Phe Arg Val Ser  Pro Asp Arg 
    1025                 1030                 1035             


Gln Ser  Ser Trp Gln Phe Gln  Arg Ser Asn Ser Asn  Ser Ser Ser 
    1040                 1045                 1050             


Val Ile  Thr Thr Glu Asp Asn  Lys Ile His Ile His  Leu Gly Ser 
    1055                 1060                 1065             


Pro Tyr  Met Gln Ala Val Ala  Ser Pro Val Arg Pro  Ala Ser Pro 
    1070                 1075                 1080             


Ser Ala  Pro Leu Gln Asp Asn  Arg Thr Gln Gly Leu  Ile Asn Gly 
    1085                 1090                 1095             


Ala Leu  Asn Lys Thr Thr Asn  Lys Val Thr Ser Ser  Ile Thr Ile 
    1100                 1105                 1110             


Thr Pro  Thr Ala Thr Pro Leu  Pro Arg Gln Ser Gln  Ile Thr Val 
    1115                 1120                 1125             


Ser Asn  Ile Tyr Asn 
    1130             


<210>  23
<211>  1135
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      


Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          


His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              


Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  


Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  


Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      


Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         


Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             


Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 


Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 


Leu Leu Val Ala Glu Lys Ser His Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     


Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         


Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             


Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 


Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 


Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     


Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         


Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             


Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 


Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 


Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     


Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         


Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             


Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 


Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 


Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     


Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         


Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             


Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 


Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 


Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     


Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         


Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             


Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 


Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 


Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     


Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         


Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             


Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 


Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 


Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     


Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         


Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             


Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 


Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 


Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     


Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            740                 745                 750         


Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        755                 760                 765             


Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    770                 775                 780                 


Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
785                 790                 795                 800 


Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                805                 810                 815     


Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            820                 825                 830         


Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        835                 840                 845             


Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    850                 855                 860                 


Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
865                 870                 875                 880 


Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                885                 890                 895     


Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            900                 905                 910         


Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        915                 920                 925             


Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    930                 935                 940                 


Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
945                 950                 955                 960 


Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                965                 970                 975     


Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            980                 985                 990         


Leu Thr Pro Glu Arg Thr Met Ser  Pro Ile Gln Val Leu  Ala Val Thr 
        995                 1000                 1005             


Gly Ser  Ala Ser Ser Pro Glu  Gln Gly Arg Ser Pro  Glu Pro Thr 
    1010                 1015                 1020             


Glu Ile  Ser Ala Lys His Ala  Ile Phe Arg Val Ser  Pro Asp Arg 
    1025                 1030                 1035             


Gln Ser  Ser Trp Gln Phe Gln  Arg Ser Asn Ser Asn  Ser Ser Ser 
    1040                 1045                 1050             


Val Ile  Thr Thr Glu Asp Asn  Lys Ile His Ile His  Leu Gly Ser 
    1055                 1060                 1065             


Pro Tyr  Met Gln Ala Val Ala  Ser Pro Val Arg Pro  Ala Ser Pro 
    1070                 1075                 1080             


Ser Ala  Pro Leu Gln Asp Asn  Arg Thr Gln Gly Leu  Ile Asn Gly 
    1085                 1090                 1095             


Ala Leu  Asn Lys Thr Thr Asn  Lys Val Thr Ser Ser  Ile Thr Ile 
    1100                 1105                 1110             


Thr Pro  Thr Ala Thr Pro Leu  Pro Arg Gln Ser Gln  Ile Thr Val 
    1115                 1120                 1125             


Glu Pro  Leu Leu Leu Pro His  
    1130                 1135 


<210>  24
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210>  25
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly 
    130                 135                 140                 


Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 
145                 150                 155                 160 


Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp 
                165                 170                 175     


Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
            180                 185     


<210>  26
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu 
            100                 105                 110         


Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr 
        115                 120                 125             


Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly 
    130                 135                 140                 


Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 
145                 150                 155                 160 


Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
                165                 170     


<210>  27
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg 
            100                 105                 110         


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
        115                 120                 125             


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
    130                 135                 140                 


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
145                 150                 155                 160 


<210>  28
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210>  29
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Leu Lys Gly Lys Arg Gly Asp Ser Gly Ser Pro Ala Thr Trp Thr 
1               5                   10                  15      


Thr Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro 
            20                  25                  30          


Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser Phe Leu 
        35                  40                  45              


Phe Val Gln Gly Asn Gln Arg Ala His Gly Gln Asp Leu Gly Thr Leu 
    50                  55                  60                  


Gly Ser Cys Leu Gln Arg Phe Thr Thr Met Pro Phe Leu Phe Cys Asn 
65                  70                  75                  80  


Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp 
                85                  90                  95      


Leu Ser Thr Pro Ala Leu Met Pro Met Asn Met Ala Pro Ile Thr Gly 
            100                 105                 110         


Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu Gly Pro 
        115                 120                 125             


Ala Ile Ala Ile Ala Val His Ser Gln Thr Thr Asp Ile Pro Pro Cys 
    130                 135                 140                 


Pro His Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser Phe Ile Met Phe 
145                 150                 155                 160 


Thr Ser Ala Gly Ser Glu Gly Thr Gly Gln Ala Leu Ala Ser Pro Gly 
                165                 170                 175     


Ser Cys Leu Glu Glu Phe Arg Ala Ser Pro Phe Leu Glu Cys His Gly 
            180                 185                 190         


Arg Gly Thr Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala 
        195                 200                 205             


Ser Leu Asn Pro Glu Arg Met Phe Arg Lys Pro Ile Pro Ser Thr Val 
    210                 215                 220                 


Lys Ala Gly Glu Leu Glu Lys Ile Ile Ser Arg Cys Gln Val Cys Met 
225                 230                 235                 240 


Lys Lys Arg His 
                


<210>  30
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


