                         SEQUENCE LISTING

<110>  Endo Pharmaceuticals Inc.
       Thompson, Scott K.
       Priestley, Tony
       Smith, Roger A.
       Saha, Ashis K.
       Rudra, Sonali
       Hajra, Arun K.
       Chatterjee, Dipanwita
       Behrens, Carl H.
       He, Yigang
       Li, Hui-Yin
 
<120>  Aminoindane Compounds and Use Thereof in Treating Pain

<130>  SKT-111-WO/END2APCT

<150>  US 61/444,379
<151>  2011-02-18

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  839
<212>  PRT
<213>  Unknown

<220>
<223>  human TRPV1

<400>  1

Met Lys Lys Trp Ser Ser Thr Asp Leu Gly Ala Ala Ala Asp Pro Leu 
1               5                   10                  15      


Gln Lys Asp Thr Cys Pro Asp Pro Leu Asp Gly Asp Pro Asn Ser Arg 
            20                  25                  30          


Pro Pro Pro Ala Lys Pro Gln Leu Ser Thr Ala Lys Ser Arg Thr Arg 
        35                  40                  45              


Leu Phe Gly Lys Gly Asp Ser Glu Glu Ala Phe Pro Val Asp Cys Pro 
    50                  55                  60                  


His Glu Glu Gly Glu Leu Asp Ser Cys Pro Thr Ile Thr Val Ser Pro 
65                  70                  75                  80  


Val Ile Thr Ile Gln Arg Pro Gly Asp Gly Pro Thr Gly Ala Arg Leu 
                85                  90                  95      


Leu Ser Gln Asp Ser Val Ala Ala Ser Thr Glu Lys Thr Leu Arg Leu 
            100                 105                 110         


Tyr Asp Arg Arg Ser Ile Phe Glu Ala Val Ala Gln Asn Asn Cys Gln 
        115                 120                 125             


Asp Leu Glu Ser Leu Leu Leu Phe Leu Gln Lys Ser Lys Lys His Leu 
    130                 135                 140                 


Thr Asp Asn Glu Phe Lys Asp Pro Glu Thr Gly Lys Thr Cys Leu Leu 
145                 150                 155                 160 


Lys Ala Met Leu Asn Leu His Asp Gly Gln Asn Thr Thr Ile Pro Leu 
                165                 170                 175     


Leu Leu Glu Ile Ala Arg Gln Thr Asp Ser Leu Lys Glu Leu Val Asn 
            180                 185                 190         


Ala Ser Tyr Thr Asp Ser Tyr Tyr Lys Gly Gln Thr Ala Leu His Ile 
        195                 200                 205             


Ala Ile Glu Arg Arg Asn Met Ala Leu Val Thr Leu Leu Val Glu Asn 
    210                 215                 220                 


Gly Ala Asp Val Gln Ala Ala Ala His Gly Asp Phe Phe Lys Lys Thr 
225                 230                 235                 240 


Lys Gly Arg Pro Gly Phe Tyr Phe Gly Glu Leu Pro Leu Ser Leu Ala 
                245                 250                 255     


Ala Cys Thr Asn Gln Leu Gly Ile Val Lys Phe Leu Leu Gln Asn Ser 
            260                 265                 270         


Trp Gln Thr Ala Asp Ile Ser Ala Arg Asp Ser Val Gly Asn Thr Val 
        275                 280                 285             


Leu His Ala Leu Val Glu Val Ala Asp Asn Thr Ala Asp Asn Thr Lys 
    290                 295                 300                 


Phe Val Thr Ser Met Tyr Asn Glu Ile Leu Met Leu Gly Ala Lys Leu 
305                 310                 315                 320 


His Pro Thr Leu Lys Leu Glu Glu Leu Thr Asn Lys Lys Gly Met Thr 
                325                 330                 335     


Pro Leu Ala Leu Ala Ala Gly Thr Gly Lys Ile Gly Val Leu Ala Tyr 
            340                 345                 350         


Ile Leu Gln Arg Glu Ile Gln Glu Pro Glu Cys Arg His Leu Ser Arg 
        355                 360                 365             


Lys Phe Thr Glu Trp Ala Tyr Gly Pro Val His Ser Ser Leu Tyr Asp 
    370                 375                 380                 


Leu Ser Cys Ile Asp Thr Cys Glu Lys Asn Ser Val Leu Glu Val Ile 
385                 390                 395                 400 


Ala Tyr Ser Ser Ser Glu Thr Pro Asn Arg His Asp Met Leu Leu Val 
                405                 410                 415     


Glu Pro Leu Asn Arg Leu Leu Gln Asp Lys Trp Asp Arg Phe Val Lys 
            420                 425                 430         


Arg Ile Phe Tyr Phe Asn Phe Leu Val Tyr Cys Leu Tyr Met Ile Ile 
        435                 440                 445             


Phe Thr Met Ala Ala Tyr Tyr Arg Pro Val Asp Gly Leu Pro Pro Phe 
    450                 455                 460                 


Lys Met Glu Lys Thr Gly Asp Tyr Phe Arg Val Thr Gly Glu Ile Leu 
465                 470                 475                 480 


Ser Val Leu Gly Gly Val Tyr Phe Phe Phe Arg Gly Ile Gln Tyr Phe 
                485                 490                 495     


Leu Gln Arg Arg Pro Ser Met Lys Thr Leu Phe Val Asp Ser Tyr Ser 
            500                 505                 510         


Glu Met Leu Phe Phe Leu Gln Ser Leu Phe Met Leu Ala Thr Val Val 
        515                 520                 525             


Leu Tyr Phe Ser His Leu Lys Glu Tyr Val Ala Ser Met Val Phe Ser 
    530                 535                 540                 


Leu Ala Leu Gly Trp Thr Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln 
545                 550                 555                 560 


Gln Met Gly Ile Tyr Ala Val Met Ile Glu Lys Met Ile Leu Arg Asp 
                565                 570                 575     


Leu Cys Arg Phe Met Phe Val Tyr Ile Val Phe Leu Phe Gly Phe Ser 
            580                 585                 590         


Thr Ala Val Val Thr Leu Ile Glu Asp Gly Lys Asn Asp Ser Leu Pro 
        595                 600                 605             


Ser Glu Ser Thr Ser His Arg Trp Arg Gly Pro Ala Cys Arg Pro Pro 
    610                 615                 620                 


Asp Ser Ser Tyr Asn Ser Leu Tyr Ser Thr Cys Leu Glu Leu Phe Lys 
625                 630                 635                 640 


Phe Thr Ile Gly Met Gly Asp Leu Glu Phe Thr Glu Asn Tyr Asp Phe 
                645                 650                 655     


Lys Ala Val Phe Ile Ile Leu Leu Leu Ala Tyr Val Ile Leu Thr Tyr 
            660                 665                 670         


Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Met Gly Glu Thr Val Asn 
        675                 680                 685             


Lys Ile Ala Gln Glu Ser Lys Asn Ile Trp Lys Leu Gln Arg Ala Ile 
    690                 695                 700                 


Thr Ile Leu Asp Thr Glu Lys Ser Phe Leu Lys Cys Met Arg Lys Ala 
705                 710                 715                 720 


Phe Arg Ser Gly Lys Leu Leu Gln Val Gly Tyr Thr Pro Asp Gly Lys 
                725                 730                 735     


Asp Asp Tyr Arg Trp Cys Phe Arg Val Asp Glu Val Asn Trp Thr Thr 
            740                 745                 750         


Trp Asn Thr Asn Val Gly Ile Ile Asn Glu Asp Pro Gly Asn Cys Glu 
        755                 760                 765             


Gly Val Lys Arg Thr Leu Ser Phe Ser Leu Arg Ser Ser Arg Val Ser 
    770                 775                 780                 


Gly Arg His Trp Lys Asn Phe Ala Leu Val Pro Leu Leu Arg Glu Ala 
785                 790                 795                 800 


Ser Ala Arg Asp Arg Gln Ser Ala Gln Pro Glu Glu Val Tyr Leu Arg 
                805                 810                 815     


Gln Phe Ser Gly Ser Leu Lys Pro Glu Asp Ala Glu Val Phe Lys Ser 
            820                 825                 830         


Pro Ala Ala Ser Gly Glu Lys 
        835                 


<210>  2
<211>  41
<212>  DNA
<213>  Unknown

<220>
<223>  forward primer based on homo sapiens

<400>  2
ataaacggta ccgccgccac catgaagaaa tggagcagca c                           41


<210>  3
<211>  33
<212>  DNA
<213>  Unknown

<220>
<223>  reverse primer based on homo sapiens

<400>  3
atcggtttaa actcacttct ctccggaagc ggc                                    33


<210>  4
<211>  2520
<212>  DNA
<213>  Unknown

<220>
<223>  human TRPV1

<400>  4
atgaagaaat ggagcagcac agacttgggg gcagctgcgg acccactcca aaaggacacc       60

tgcccagacc ccctggatgg agaccctaac tccaggccac ctccagccaa gccccagctc      120

tccacggcca agagccgcac ccggctcttt gggaagggtg actcggagga ggctttcccg      180

gtggattgcc ctcacgagga aggtgagctg gactcctgcc cgaccatcac agtcagccct      240

gttatcacca tccagaggcc aggagacggc cccaccggtg ccaggctgct gtcccaggac      300

tctgtcgccg ccagcaccga gaagaccctc aggctctatg atcgcaggag tatctttgaa      360

gccgttgctc agaataactg ccaggatctg gagagcctgc tgctcttcct gcagaagagc      420

aagaagcacc tcacagacaa cgagttcaaa gaccctgaga cagggaagac ctgtctgctg      480

aaagccatgc tcaacctgca cgacggacag aacaccacca tccccctgct cctggagatc      540

gcgcggcaaa cggacagcct gaaggagctt gtcaacgcca gctacacgga cagctactac      600

aagggccaga cagcactgca catcgccatc gagagacgca acatggccct ggtgaccctc      660

ctggtggaga acggagcaga cgtccaggct gcggcccatg gggacttctt taagaaaacc      720

aaagggcggc ctggattcta cttcggtgaa ctgcccctgt ccctggccgc gtgcaccaac      780

cagctgggca tcgtgaagtt cctgctgcag aactcctggc agacggccga catcagcgcc      840

agggactcgg tgggcaacac ggtgctgcac gccctggtgg aggtggccga caacacggcc      900

gacaacacga agtttgtgac gagcatgtac aatgagattc tgatcctggg ggccaaactg      960

cacccgacgc tgaagctgga ggagctcacc aacaagaagg gaatgacgcc gctggctctg     1020

gcagctggga ccgggaagat cggggtcttg gcctatattc tccagcggga gatccaggag     1080

cccgagtgca ggcacctgtc caggaagttc accgagtggg cctacgggcc cgtgcactcc     1140

tcgctgtacg acctgtcctg catcgacacc tgcgagaaga actcggtgct ggaggtgatc     1200

gcctacagca gcagcgagac ccctaatcgc cacgacatgc tcttggtgga gccgctgaac     1260

cgactcctgc aggacaagtg ggacagattc gtcaagcgca tcttctactt caacttcctg     1320

gtctactgcc tgtacatgat catcttcacc atggctgcct actacaggcc cgtggatggc     1380

ttgcctccct ttaagatgga aaaaactgga gactatttcc gagttactgg agagatcctg     1440

tctgtgttag gaggagtcta cttctttttc cgagggattc agtatttcct gcagaggcgg     1500

ccgtcgatga agaccctgtt tgtggacagc tacagtgaga tgcttttctt tctgcagtca     1560

ctgttcatgc tggccaccgt ggtgctgtac ttcagccacc tcaaggagta tgtggcttcc     1620

atggtattct ccctggcctt gggctggacc aacatgctct actacacccg cggtttccag     1680

cagatgggca tctatgccgt catgatagag aagatgatcc tgagagacct gtgccgtttc     1740

atgtttgtct acatcgtctt cttgttcggg ttttccacag cggtggtgac gctgattgaa     1800

gacgggaaga atgactccct gccgtctgag tccacgtcgc acaggtggcg ggggcctgcc     1860

tgcaggcccc ccgatagctc ctacaacagc ctgtactcca cctgcctgga gctgttcaag     1920

ttcaccatcg gcatgggcga cctggagttc actgagaact atgacttcaa ggctgtcttc     1980

atcatcctgc tgctggccta tgtaattctc acctacatcc tcctgctcaa catgctcatc     2040

gccctcatgg gtgagactgt caacaagatc gcacaggaga gcaagaacat ctggaagctg     2100

cagagagcca tcaccatcct ggacacggag aagagcttcc ttaagtgcat gaggaaggcc     2160

ttccgctcag gcaagctgct gcaggtgggg tacacacctg atggcaagga cgactaccgg     2220

tggtgcttca gggtggacga ggtgaactgg accacctgga acaccaacgt gggcatcatc     2280

aacgaagacc cgggcaactg tgagggcgtc aagcgcaccc tgagcttctc cctgcggtca     2340

agcagagttt caggcagaca ctggaagaac tttgccctgg tccccctttt aagagaggca     2400

agtgctcgag ataggcagtc tgctcagccc gaggaagttt atctgcgaca gttttcaggg     2460

tctctgaagc cagaggacgc tgaggtcttc aagagtcctg ccgcttccgg agagaagtga     2520


