  
                                  SEQUENCE LISTING
  
  <110> Cornell University
        Ma, Xiaojing
        
  
  <120> METHODS TO ENHANCE CELL-MEDIATED IMMUNITY
  
  <130> 1676.070WO1
  
  <150> US 61/443,569       
  <151> 2011-02-16  
  
  <160> 19
  
  <170> FastSEQ for Windows Version 4.0
  
  <210> 1
  <211> 400
  <212> PRT
  <213> Homo sapiens
  
  <400> 1
  Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu Val
   1               5                  10                  15
  Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr Trp
              20                  25                  30
  Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu Leu
          35                  40                  45
  Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu
      50                  55                  60
  Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu
  65                  70                  75                  80
  Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn Lys
                  85                  90                  95
  Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly
              100                 105                 110
  Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg
          115                 120                 125
  Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln
      130                 135                 140
  Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn
  145                 150                 155                 160
  Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu Val
                  165                 170                 175
  Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu Asn
              180                 185                 190
  Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro Arg
          195                 200                 205
  Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys Gly
      210                 215                 220
  Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser Glu
  225                 230                 235                 240
  Val Val Leu Asp Ser Lys Arg Arg Val Glu Lys Glu Glu Thr Asn Glu
                  245                 250                 255
  Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln Glu
              260                 265                 270
  Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg Gly
          275                 280                 285
  Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala Ala
      290                 295                 300
  Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg Asp
  305                 310                 315                 320
  Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala Gly
                  325                 330                 335
  Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn Met
              340                 345                 350
  Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu Ala
          355                 360                 365
  Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys Arg
      370                 375                 380
  Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr Leu
  385                 390                 395                 400
  
  <210> 2
  <211> 347
  <212> PRT
  <213> Homo sapiens
  
  <400> 2
  Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu Lys Lys Asn Glu Phe
   1               5                  10                  15
  Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu Asp Lys Ile Gln Ser
              20                  25                  30
  Ser His Asn Phe Gln Leu Glu Ser Val Asn Lys Leu Tyr Gln Asp Glu
          35                  40                  45
  Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly Glu Arg Leu Ile Arg
      50                  55                  60
  Val Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg Asn Tyr Gly Arg Leu
  65                  70                  75                  80
  Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln Thr Asn Leu Glu Arg
                  85                  90                  95
  Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn Gln Met Lys Glu Val
              100                 105                 110
  Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu Val Thr Lys Lys Gly Asn
          115                 120                 125
  Glu Ala Val Ala Ser Arg Asp Leu Ser Glu Asn Asn Asp Gln Arg Gln
      130                 135                 140
  Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro Arg Leu Gln Ala Ala Gly
  145                 150                 155                 160
  Leu Pro His Thr Glu Val Pro Gln Gly Lys Gly Asn Val Leu Gly Asn
                  165                 170                 175
  Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser Glu Val Val Leu Asp Ser
              180                 185                 190
  Lys Arg Arg Val Glu Lys Glu Glu Thr Asn Glu Ile Gln Val Val Asn
          195                 200                 205
  Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln Glu Pro Gly Arg Glu Gln
      210                 215                 220
  Val Val Glu Asp Arg Pro Val Gly Gly Arg Gly Phe Gly Gly Ala Gly
  225                 230                 235                 240
  Glu Leu Gly Gln Thr Pro Gln Val Gln Ala Ala Leu Ser Val Ser Gln
                  245                 250                 255
  Glu Asn Pro Glu Met Glu Gly Pro Glu Arg Asp Gln Leu Val Ile Pro
              260                 265                 270
  Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala Gly Glu Gly Arg Asn Gln
          275                 280                 285
  Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn Met Asp Glu Asn Glu Ala
      290                 295                 300
  Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu Ala Gly Asn Asp Arg Asn
  305                 310                 315                 320
  Ile Asp Val Phe Asn Val Glu Asp Gln Lys Arg Asp Thr Ile Asn Leu
                  325                 330                 335
  Leu Asp Gln Arg Glu Lys Arg Asn His Thr Leu
              340                 345
  
  <210> 3
  <211> 23
  <212> PRT
  <213> Homo sapiens
  
  <400> 3
  Ser Pro Pro Leu Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu
   1               5                  10                  15
  Gly Phe Asn Tyr Trp Ile Ala
              20
  
  <210> 4
  <211> 366
  <212> PRT
  <213> Homo sapiens
  
  <400> 4
  Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu Leu Glu Gly
   1               5                  10                  15
  Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu Lys Lys
              20                  25                  30
  Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu Asp Lys
          35                  40                  45
  Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn Lys Leu Tyr
      50                  55                  60
  Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly Glu Arg
  65                  70                  75                  80
  Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg Asn Tyr
                  85                  90                  95
  Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln Thr Asn
              100                 105                 110
  Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn Gln Met
          115                 120                 125
  Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu Val Thr Lys
      130                 135                 140
  Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu Asn Asn Asp
  145                 150                 155                 160
  Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro Arg Leu Gln
                  165                 170                 175
  Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys Gly Asn Val
              180                 185                 190
  Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser Glu Val Val
          195                 200                 205
  Leu Asp Ser Lys Arg Arg Val Glu Lys Glu Glu Thr Asn Glu Ile Gln
      210                 215                 220
  Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln Glu Pro Gly
  225                 230                 235                 240
  Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg Gly Phe Gly
                  245                 250                 255
  Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala Ala Leu Ser
              260                 265                 270
  Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg Asp Gln Leu
          275                 280                 285
  Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala Gly Glu Gly
      290                 295                 300
  Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn Met Asp Glu
  305                 310                 315                 320
  Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu Ala Gly Asn
                  325                 330                 335
  Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys Arg Asp Thr
              340                 345                 350
  Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr Leu
          355                 360                 365
  
  <210> 5
  <211> 169
  <212> PRT
  <213> Homo sapiens
  
  <400> 5
  Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu Leu Glu Gly
   1               5                  10                  15
  Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu Lys Lys
              20                  25                  30
  Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu Asp Lys
          35                  40                  45
  Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn Lys Leu Tyr
      50                  55                  60
  Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly Glu Arg
  65                  70                  75                  80
  Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg Asn Tyr
                  85                  90                  95
  Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln Thr Asn
              100                 105                 110
  Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn Gln Met
          115                 120                 125
  Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu Val Thr Lys
      130                 135                 140
  Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu Asn Asn Asp
  145                 150                 155                 160
  Gln Arg Gln Gln Leu Gln Ala Leu Ser
                  165
  
  <210> 6
  <211> 150
  <212> PRT
  <213> Homo sapiens
  
  <400> 6
  Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu Lys Lys Asn Glu Phe
   1               5                  10                  15
  Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu Asp Lys Ile Gln Ser
              20                  25                  30
  Ser His Asn Phe Gln Leu Glu Ser Val Asn Lys Leu Tyr Gln Asp Glu
          35                  40                  45
  Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly Glu Arg Leu Ile Arg
      50                  55                  60
  Val Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg Asn Tyr Gly Arg Leu
  65                  70                  75                  80
  Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln Thr Asn Leu Glu Arg
                  85                  90                  95
  Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn Gln Met Lys Glu Val
              100                 105                 110
  Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu Val Thr Lys Lys Gly Asn
          115                 120                 125
  Glu Ala Val Ala Ser Arg Asp Leu Ser Glu Asn Asn Asp Gln Arg Gln
      130                 135                 140
  Gln Leu Gln Ala Leu Ser
  145                 150
  
  <210> 7
  <211> 37
  <212> PRT
  <213> Homo sapiens
  
  <400> 7
  Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu Lys Lys Asn Glu Phe
   1               5                  10                  15
  Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu Asp Lys Ile Gln Ser
              20                  25                  30
  Ser His Asn Phe Gln
          35
  
  <210> 8
  <211> 40
  <212> PRT
  <213> Homo sapiens
  
  <400> 8
  Leu Glu Ser Val Asn Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val
   1               5                  10                  15
  Asn Asn Ile Thr Thr Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln
              20                  25                  30
  Leu Lys Thr Leu Gln Arg Asn Tyr
          35                  40
  
  <210> 9
  <211> 40
  <212> PRT
  <213> Homo sapiens
  
  <400> 9
  Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln Thr Asn
   1               5                  10                  15
  Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn Gln Met
              20                  25                  30
  Lys Glu Val Lys Glu Gln Cys Glu
          35                  40
  
  <210> 10
  <211> 40
  <212> PRT
  <213> Homo sapiens
  
  <400> 10
  Glu Arg Ile Glu Glu Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser
   1               5                  10                  15
  Arg Asp Leu Ser Glu Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu
              20                  25                  30
  Ser Glu Pro Gln Pro Arg Leu Gln
          35                  40
  
  <210> 11
  <211> 40
  <212> PRT
  <213> Homo sapiens
  
  <400> 11
  Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys Gly Asn Val
   1               5                  10                  15
  Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser Glu Val Val
              20                  25                  30
  Leu Asp Ser Lys Arg Arg Val Glu
          35                  40
  
  <210> 12
  <211> 40
  <212> PRT
  <213> Homo sapiens
  
  <400> 12
  Lys Glu Glu Thr Asn Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg
   1               5                  10                  15
  Asp Arg Leu Pro Gln Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg
              20                  25                  30
  Pro Val Gly Gly Arg Gly Phe Gly
          35                  40
  
  <210> 13
  <211> 40
  <212> PRT
  <213> Homo sapiens
  
  <400> 13
  Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala Ala Leu Ser
   1               5                  10                  15
  Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg Asp Gln Leu
              20                  25                  30
  Val Ile Pro Asp Gly Gln Glu Glu
          35                  40
  
  <210> 14
  <211> 40
  <212> PRT
  <213> Homo sapiens
  
  <400> 14
  Glu Gln Glu Ala Ala Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly
   1               5                  10                  15
  Glu Asp Asp Tyr Asn Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp
              20                  25                  30
  Lys Gln Ala Ala Leu Ala Gly Asn
          35                  40
  
  <210> 15
  <211> 30
  <212> PRT
  <213> Homo sapiens
  
  <400> 15
  Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys Arg Asp Thr
   1               5                  10                  15
  Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr Leu
              20                  25                  30
  
  <210> 16
  <211> 1203
  <212> DNA
  <213> Homo sapiens
  
  <400> 16
  atgggcttgg gaaacgggcg tcgcagcatg aagtcgccgc ccctcgtgct ggccgccctg      60
  gtggcctgca tcatcgtctt gggcttcaac tactggattg cgagctcccg gagcgtggac     120
  ctccagacac ggatcatgga gctggaaggc agggtccgca gggcggctgc agagagaggc     180
  gccgtggagc tgaagaagaa cgagttccag ggagagctgg agaagcagcg ggagcagctt     240
  gacaaaatcc agtccagcca caacttccag ctggagagcg tcaacaagct gtaccaggac     300
  gaaaaggcgg ttttggtgaa taacatcacc acaggtgaga ggctcatccg agtgctgcaa     360
  gaccagttaa agaccctgca gaggaattac ggcaggctgc agcaggatgt cctccagttt     420
  cagaagaacc agaccaacct ggagaggaag ttctcctacg acctgagcca gtgcatcaat     480
  cagatgaagg aggtgaagga acagtgtgag gagcgaatag aagaggtcac caaaaagggg     540
  aatgaagctg tagcttccag agacctgagt gaaaacaacg accagagaca gcagctccaa     600
  gccctcagtg agcctcagcc caggctgcag gcagcaggcc tgccacacac agaggtgcca     660
  caagggaagg gaaacgtgct tggtaacagc aagtcccaga caccagcccc cagttccgaa     720
  gtggttttgg attcaaagag acgagttgag aaagaggaaa ccaatgagat ccaggtggtg     780
  aatgaggagc ctcagaggga caggctgccg caggagccag gccgggagca ggtggtggaa     840
  gacagacctg taggtggaag aggcttcggg ggagccggag aactgggcca gaccccacag     900
  gtgcaggctg ccctgtcagt gagccaggaa aatccagaga tggagggccc tgagcgagac     960
  cagcttgtca tccccgacgg acaggaggag gagcaggaag ctgccgggga agggagaaac    1020
  cagcagaaac tgagaggaga agatgactac aacatggatg aaaatgaagc agaatctgag    1080
  acagacaagc aagcagccct ggcagggaat gacagaaaca tagatgtttt taatgttgaa    1140
  gatcagaaaa gagacaccat aaatttactt gatcagcgtg aaaagcggaa tcatacactt    1200
  taa                                                                  1203
  
  <210> 17
  <211> 401
  <212> PRT
  <213> Homo sapiens
  
  <400> 17
  Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu
   1               5                  10                  15
  Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr
              20                  25                  30
  Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu
          35                  40                  45
  Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu
      50                  55                  60
  Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln
  65                  70                  75                  80
  Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn
                  85                  90                  95
  Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr
              100                 105                 110
  Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln
          115                 120                 125
  Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn
      130                 135                 140
  Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile
  145                 150                 155                 160
  Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu
                  165                 170                 175
  Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu
              180                 185                 190
  Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro
          195                 200                 205
  Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys
      210                 215                 220
  Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser
  225                 230                 235                 240
  Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn
                  245                 250                 255
  Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln
              260                 265                 270
  Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg
          275                 280                 285
  Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala
      290                 295                 300
  Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg
  305                 310                 315                 320
  Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala
                  325                 330                 335
  Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn
              340                 345                 350
  Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu
          355                 360                 365
  Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys
      370                 375                 380
  Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr
  385                 390                 395                 400
  Leu
  
  
  <210> 18
  <211> 1429
  <212> DNA
  <213> Homo sapiens
  
  <400> 18
  gctcgaggcc ggcggcggcg ggagagcgac ccgggcggcc tcgtagcggg gccccggatc      60
  cccgagtggc ggccggagcc tcgaaaagag attctcagcg ctgattttga gatgatgggc     120
  ttgggaaacg ggcgtcgcag catgaagtcg ccgcccctcg tgctggccgc cctggtggcc     180
  tgcatcatcg tcttgggctt caactactgg attgcgagct cccggagcgt ggacctccag     240
  acacggatca tggagctgga aggcagggtc cgcagggcgg ctgcagagag aggcgccgtg     300
  gagctgaaga agaacgagtt ccagggagag ctggagaagc agcgggagca gcttgacaaa     360
  atccagtcca gccacaactt ccagctggag agcgtcaaca agctgtacca ggacgaaaag     420
  gcggttttgg tgaataacat caccacaggt gagaggctca tccgagtgct gcaagaccag     480
  ttaaagaccc tgcagaggaa ttacggcagg ctgcagcagg atgtcctcca gtttcagaag     540
  aaccagacca acctggagag gaagttctcc tacgacctga gccagtgcat caatcagatg     600
  aaggaggtga aggaacagtg tgaggagcga atagaagagg tcaccaaaaa ggggaatgaa     660
  gctgtagctt ccagagacct gagtgaaaac aacgaccaga gacagcagct ccaagccctc     720
  agtgagcctc agcccaggct gcaggcagca ggcctgccac acacagaggt gccacaaggg     780
  aagggaaacg tgcttggtaa cagcaagtcc cagacaccag cccccagttc cgaagtggtt     840
  ttggattcaa agagacaagt tgagaaagag gaaaccaatg agatccaggt ggtgaatgag     900
  gagcctcaga gggacaggct gccgcaggag ccaggccggg agcaggtggt ggaagacaga     960
  cctgtaggtg gaagaggctt cgggggagcc ggagaactgg gccagacccc acaggtgcag    1020
  gctgccctgt cagtgagcca ggaaaatcca gagatggagg gccctgagcg agaccagctt    1080
  gtcatccccg acggacagga ggaggagcag gaagctgccg gggaagggag aaaccagcag    1140
  aaactgagag gagaagatga ctacaacatg gatgaaaatg aagcagaatc tgagacagac    1200
  aagcaagcag ccctggcagg gaatgacaga aacatagatg tttttaatgt tgaagatcag    1260
  aaaagagaca ccataaattt acttgatcag cgtgaaaagc ggaatcatac actctgaatt    1320
  gaactggaat cacatatttc acaacagggc cgaagagatg actataaaat gttcatgagg    1380
  gactgaatac tgaaaactgt gaaatgtact aaataaaatg tacatctga                1429
  
  <210> 19
  <211> 21
  <212> RNA
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic siRNA
  
  <220>
  <221> misc_feature   
  <222> (20)...(21)
  <223> n = deoxythymidine
  
  <400> 19
  accucuugug gcuuugcuan n                                                21
