
                                SEQUENCE LISTING

<110> Vaxiion Therapeutics, Inc.
      Giacalone, Matthew J.
      Newman, Michael J.

<120> THERAPEUTIC COMPOSITIONS AND METHODS FOR
  ANTIBODY AND FC-CONTAINING TARGETING MOLECULE-BASED TARGETED
  DELIVERY OF BIOACTIVE MOLECULES BY BACTERIAL MINICELLS
  

<130> VAX.024WO

<150> 61/442999           
<151> 2011-02-15  

<150> 61/526219           
<151> 2011-08-22  

<160> 42

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5748
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-119

<400> 1
tcgacatgaa agctaccaaa ctggttctgg gtgctgtcat cctgggctca acgctgctgg 60
cgggctgttc ttccaatgcg aaaatcgatc aaggcattaa cccgtatgtc ggctttgaaa 120
tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat ggtgcataca 180
aagctcaggg cgtccaactg accgctaaac tgggttatcc gattaccgat gacctggata 240
tctacacgcg tctgggcggt atggtctggc gtgcagatac caaatcaaac gtgtatggca 300
aaaatcatga cacgggtgtg tcgccggttt ttgcaggcgg tgttgaatat gctattaccc 360
cggaaatcgc gacgcgtctg gaataccagt ggacgaacaa tattggcgat gcgcatacca 420
tcggtacgcg tccggacaac ggtattccgg gtgcagccaa tgcagctcag cacgatgaag 480
cgcagcaaaa cgccttttat caggtgctga atatgccgaa cctgaatgcc gatcagcgca 540
acggcttcat ccaaagcctg aaagatgacc cgagccagtc tgccaacgtt ctgggtgaag 600
cacagaaact gaatgatagc caagcgccga aagcggacgc ccagcagaac aacttcaaca 660
aagatcagca atctgctttc tatgaaattc tgaacatgcc gaacctgaat gaagcgcagc 720
gtaatggctt tatccaaagt ctgaaagatg acccgagtca gtccaccaac gtgctgggtg 780
aagccaaaaa actgaatgaa tcccaggcgc cgaaagccga taacaacttc aacaaagaac 840
agcaaaacgc attctacgaa atcctgaata tgccgaatct gaatgaagaa cagcgcaatg 900
gcttcatcca atcactgaaa gatgacccgt cacagtcggc taacctgctg agcgaggcga 960
aaaaattaaa cgaatcccag gcaccgaaag ctgataacaa atttaataaa gaacagcaaa 1020
acgccttcta tgaaattctg catctgccga atctgaacga agaacagcgt aatggtttta 1080
tccaatcgct gaaagacgat ccgagccagt ctgcgaacct gctggcagaa gctaaaaaac 1140
tgaatgatgc gcaggccccg aaagccgaca acaaatttaa caaagaacaa cagaatgcat 1200
tctacgaaat tctgcacctg ccgaacctga ccgaagaaca acgtaatggc ttcatccaat 1260
ccctgaaaga tgacccgagt gtctccaaag aaatcctggc tgaagcgaaa aaactgaacg 1320
atgctcaagc tccgaaataa taatctagag gatccccgcg ccctcatccg aaagggcgta 1380
tgggtaccga gctcgaattc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat 1440
ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc 1500
taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga 1560
aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt 1620
attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg 1680
cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac 1740
gcaggaaaga acatgtgagc aaaaggccag caaaagccca ggaaccgtaa aaaggccgcg 1800
ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca 1860
agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc 1920
tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc 1980
ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag 2040
gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc 2100
ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca 2160
gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg 2220
aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg 2280
aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct 2340
ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa 2400
gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa 2460
gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa 2520
tgaagtttta gcacgtgcta ttattgaagc atttatcagg gttattgtct catgagcgga 2580
tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga 2640
aaagtgccac ctgtatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca 2700
tcaggaaatt gtaagcgtta ataattcaga agaactcgtc aagaaggcga tagaaggcga 2760
tgcgctgcga atcgggagcg gcgataccgt aaagcacgag gaagcggtca gcccattcgc 2820
cgccaagctc ttcagcaata tcacgggtag ccaacgctat gtcctgatag cggtccgcca 2880
cacccagccg gccacagtcg atgaatccag aaaagcggcc attttccacc atgatattcg 2940
gcaagcaggc atcgccatgg gtcacgacga gatcctcgcc gtcgggcatg ctcgccttga 3000
gcctggcgaa cagttcggct ggcgcgagcc cctgatgctc ttcgtccaga tcatcctgat 3060
cgacaagacc ggcttccatc cgagtacgtg ctcgctcgat gcgatgtttc gcttggtggt 3120
cgaatgggca ggtagccgga tcaagcgtat gcagccgccg cattgcatca gccatgatgg 3180
atactttctc ggcaggagca aggtgagatg acaggagatc ctgccccggc acttcgccca 3240
atagcagcca gtcccttccc gcttcagtga caacgtcgag cacagctgcg caaggaacgc 3300
ccgtcgtggc cagccacgat agccgcgctg cctcgtcttg cagttcattc agggcaccgg 3360
acaggtcggt cttgacaaaa agaaccgggc gcccctgcgc tgacagccgg aacacggcgg 3420
catcagagca gccgattgtc tgttgtgccc agtcatagcc gaatagcctc tccacccaag 3480
cggccggaga acctgcgtgc aatccatctt gttcaatcat gcgaaacgat cctcatcctg 3540
tctcttgatc agagcttgat cccctgcgcc atcagatcct tggcggcgag aaagccatcc 3600
agtttacttt gcagggcttc ccaaccttac cagagggcgc cccagctggc aattccggtt 3660
cgcttgctgt ccataaaacc gcccagtaga agcatatgaa gcttaattaa tctttctgcg 3720
aattgagatg acgccactgg ctgggcgtca tcccggtttc ccgggtaaac accaccgaaa 3780
aatagttact atcttcaaag ccacattcgg tcgaaatatc actgattaac aggcggctat 3840
gctggagaag atattgcgca tgacacactc tgacctgtcg cagatattga ttgatggtca 3900
ttccagtctg ctggcgaaat tgctgacgca aaacgcgctc actgcacgat gcctcatcac 3960
aaaatttatc cagcgcaaag ggacttttca ggctagccgc cagccgggta atcagcttat 4020
ccagcaacgt ttcgctggat gttggcggca acgaatcact ggtgtaacga tggcgattca 4080
gcaacatcac caactgcccg aacagcaact cagccatttc gttagcaaac ggcacatgct 4140
gactactttc atgctcaagc tgaccgataa cctgccgcgc ctgcgccatc cccatgctac 4200
ctaagcgcca gtgtggttgc cctgcgctgg cgttaaatcc cggaatcgcc ccctgccagt 4260
caagattcag cttcagacgc tccgggcaat aaataatatt ctgcaaaacc agatcgttaa 4320
cggaagcgta ggagtgttta tcgtcagcat gaatgtaaaa gagatcgcca cgggtaatgc 4380
gataagggcg atcgttgagt acatgcaggc cattaccgcg ccagacaatc accagctcac 4440
aaaaatcatg tgtatgttca gcaaagacat cttgcggata acggtcagcc acagcgactg 4500
cctgctggtc gctggcaaaa aaatcatctt tgagaagttt taactgatgc gccaccgtgg 4560
ctacctcggc cagagaacga agttgattat tcgcaatatg gcgtacaaat acgttgagaa 4620
gattcgcgtt attgcagaaa gccatcccgt ccctggcgaa tatcacgcgg tgaccagtta 4680
aactctcggc gaaaaagcgt cgaaaagtgg ttactgtcgc tgaatccaca gcgataggcg 4740
atgtcagtaa cgctggcctc gctgtggcgt agcagatgtc gggctttcat cagtcgcagg 4800
cggttcaggt atcgctgagg cgtcagtccc gtttgctgct taagctgccg atgtagcgta 4860
cgcagtgaaa gagaaaattg atccgccacg gcatcccaat tcacctcatc ggcaaaatgg 4920
tcctccagcc aggccagaag caagttgaga cgtgatgcgc tgttttccag gttctcctgc 4980
aaactgcttt tacgcagcaa gagcagtaat tgcataaaca agatctcgcg actggcggtc 5040
gagggtaaat cattttcccc ttcctgctgt tccatctgtg caaccagctg tcgcacctgc 5100
tgcaatacgc tgtggttaac gcgccagtga gacggatact gcccatccag ctcttgtggc 5160
agcaactgat tcagcccggc gagaaactga aatcgatccg gcgagcgata cagcacattg 5220
gtcagacaca gattatcggt atgttcatac agatgccgat catgatcgcg tacgaaacag 5280
accgtgccac cggtgatggt atagggctgc ccattaaaca catgaatacc cgtgccatgt 5340
tcgacaatca caatttcatg aaaatcatga tgatgttcag gaaaatccgc ctgcgggagc 5400
cggggttcta tcgccacgga cgcgttacca gacggaaaaa aatccacact atgtaatacg 5460
gtcatactgg cctcctgatg tcgtcaacac ggcgaaatag taatcacgag gtcaggttct 5520
taccttaaat tttcgacgga aaaccacgta aaaaacgtcg atttttcaag atacagcgtg 5580
aattttcagg aaatgcggtg agcatcacat caccacaatt cagcaaattg tgaacatcat 5640
cacgttcatc tttccctggt tgccaatggc ccattttcct gtcagtaacg agaaggtcgc 5700
gaattcaggc gctttttaga ctggtcgtaa tgaaattcag gaggatgg              5748<210> 2
<211> 5484
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-120

<400> 2
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaggatc cccgcgccct catccgaaag ggcgtatggg taccgagctc 3180
gaattcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc 3240
acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta 3300
actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca 3360
gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc 3420
cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc 3480
tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat 3540
gtgagcaaaa ggccagcaaa agcccaggaa ccgtaaaaag gccgcgttgc tggcgttttt 3600
ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg 3660
aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc 3720
tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt 3780
ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa 3840
gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta 3900
tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa 3960
caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa 4020
ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt 4080
cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt 4140
ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat 4200
cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat 4260
gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttagcac 4320
gtgctattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg 4380
tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctgt 4440
atgcggtgtg aaataccgca cagatgcgta aggagaaaat accgcatcag gaaattgtaa 4500
gcgttaataa ttcagaagaa ctcgtcaaga aggcgataga aggcgatgcg ctgcgaatcg 4560
ggagcggcga taccgtaaag cacgaggaag cggtcagccc attcgccgcc aagctcttca 4620
gcaatatcac gggtagccaa cgctatgtcc tgatagcggt ccgccacacc cagccggcca 4680
cagtcgatga atccagaaaa gcggccattt tccaccatga tattcggcaa gcaggcatcg 4740
ccatgggtca cgacgagatc ctcgccgtcg ggcatgctcg ccttgagcct ggcgaacagt 4800
tcggctggcg cgagcccctg atgctcttcg tccagatcat cctgatcgac aagaccggct 4860
tccatccgag tacgtgctcg ctcgatgcga tgtttcgctt ggtggtcgaa tgggcaggta 4920
gccggatcaa gcgtatgcag ccgccgcatt gcatcagcca tgatggatac tttctcggca 4980
ggagcaaggt gagatgacag gagatcctgc cccggcactt cgcccaatag cagccagtcc 5040
cttcccgctt cagtgacaac gtcgagcaca gctgcgcaag gaacgcccgt cgtggccagc 5100
cacgatagcc gcgctgcctc gtcttgcagt tcattcaggg caccggacag gtcggtcttg 5160
acaaaaagaa ccgggcgccc ctgcgctgac agccggaaca cggcggcatc agagcagccg 5220
attgtctgtt gtgcccagtc atagccgaat agcctctcca cccaagcggc cggagaacct 5280
gcgtgcaatc catcttgttc aatcatgcga aacgatcctc atcctgtctc ttgatcagag 5340
cttgatcccc tgcgccatca gatccttggc ggcgagaaag ccatccagtt tactttgcag 5400
ggcttcccaa ccttaccaga gggcgcccca gctggcaatt ccggttcgct tgctgtccat 5460
aaaaccgccc agtagaagca tatg                                        5484<210> 3
<211> 7051
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-127

<400> 3
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagagctga ggagggattg agcgatgtct gcattcaata aagaaaattc 3180
aatttcatcc atggcaccac cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa 3240
gaaacacgcg gatgaaatcg ataagtatat acaaggattg gattacaata aaaacaatgt 3300
attagtatac cacggagatg cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg 3360
aaatgaatat attgttgtgg agaaaaagaa gaaatccatc aatcaaaata atgcagacat 3420
tcaagttgtg aatgcaattt cgagcctaac ctatccaggt gctctcgtaa aagcgaattc 3480
ggaattagta gaaaatcaac cagatgttct ccctgtaaaa cgtgattcat taacactcag 3540
cattgatttg ccaggtatga ctaatcaaga caataaaata gttgtaaaaa atgccactaa 3600
atcaaacgtt aacaacgcag taaatacatt agtggaaaga tggaatgaaa aatatgctca 3660
agcttatcca aatgtaagtg caaaaattga ttatgatgac gaaatggctt acagtgaatc 3720
acaattaatt gcgaaatttg gtacagcatt taaagctgta aataatagct tgaatgtaaa 3780
cttcggcgca atcagtgaag ggaaaatgca agaagaagtc attagtttta aacaaattta 3840
ctataacgtg aatgttaatg aacctacaag accttccaga tttttcggca aagctgttac 3900
taaagagcag ttgcaagcgc ttggagtgaa tgcagaaaat cctcctgcat atatctcaag 3960
tgtggcgtat ggccgtcaag tttatttgaa attatcaact aattcccata gtactaaagt 4020
aaaagctgct tttgatgctg ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac 4080
aaatatcatc aaaaattctt ccttcaaagc cgtaatttac ggaggttccg caaaagatga 4140
agttcaaatc atcgacggca acctcggaga cttacgcgat attttgaaaa aaggcgctac 4200
ttttaatcga gaaacaccag gagttcccat tgcttataca acaaacttcc taaaagacaa 4260
tgaattagct gttattaaaa acaactcaga atatattgaa acaacttcaa aagcttatac 4320
agatggaaaa attaacatcg atcactctgg aggatacgtt gctcaattca acatttcttg 4380
ggatgaagta aattatgatc ctgaaggtaa cgaaattgtt caacataaaa actggagcga 4440
aaacaataaa agcaagctag ctcatttcac atcgtccatc tatttgcctg gtaacgcgag 4500
aaatattaat gtttacgcta aagaatgcac tggtttagct tgggaatggt ggagaacggt 4560
aattgatgac cggaacttac cacttgtgaa aaatagaaat atctccatct ggggcaccac 4620
gctttatccg aaatatagta ataaagtaga taatccaatc gaatatgatt ataaagatga 4680
cgatgacaaa taataatcta gaggatcccc gcgccctcat ccgaaagggc gtatgggtac 4740
cgagctcgaa ttcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca 4800
caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag 4860
tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt 4920
cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc 4980
gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg 5040
tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa 5100
agaacatgtg agcaaaaggc cagcaaaagc ccaggaaccg taaaaaggcc gcgttgctgg 5160
cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga 5220
ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg 5280
tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg 5340
gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc 5400
gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg 5460
gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca 5520
ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt 5580
ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag 5640
ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg 5700
gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc 5760
ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt 5820
tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt 5880
ttagcacgtg ctattattga agcatttatc agggttattg tctcatgagc ggatacatat 5940
ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc 6000
cacctgtatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggaa 6060
attgtaagcg ttaataattc agaagaactc gtcaagaagg cgatagaagg cgatgcgctg 6120
cgaatcggga gcggcgatac cgtaaagcac gaggaagcgg tcagcccatt cgccgccaag 6180
ctcttcagca atatcacggg tagccaacgc tatgtcctga tagcggtccg ccacacccag 6240
ccggccacag tcgatgaatc cagaaaagcg gccattttcc accatgatat tcggcaagca 6300
ggcatcgcca tgggtcacga cgagatcctc gccgtcgggc atgctcgcct tgagcctggc 6360
gaacagttcg gctggcgcga gcccctgatg ctcttcgtcc agatcatcct gatcgacaag 6420
accggcttcc atccgagtac gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg 6480
gcaggtagcc ggatcaagcg tatgcagccg ccgcattgca tcagccatga tggatacttt 6540
ctcggcagga gcaaggtgag atgacaggag atcctgcccc ggcacttcgc ccaatagcag 6600
ccagtccctt cccgcttcag tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt 6660
ggccagccac gatagccgcg ctgcctcgtc ttgcagttca ttcagggcac cggacaggtc 6720
ggtcttgaca aaaagaaccg ggcgcccctg cgctgacagc cggaacacgg cggcatcaga 6780
gcagccgatt gtctgttgtg cccagtcata gccgaatagc ctctccaccc aagcggccgg 6840
agaacctgcg tgcaatccat cttgttcaat catgcgaaac gatcctcatc ctgtctcttg 6900
atcagagctt gatcccctgc gccatcagat ccttggcggc gagaaagcca tccagtttac 6960
tttgcagggc ttcccaacct taccagaggg cgccccagct ggcaattccg gttcgcttgc 7020
tgtccataaa accgcccagt agaagcatat g                                7051<210> 4
<211> 7340
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-175

<400> 4
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtct ctctgccgat tgctcaacaa acggaagctg gcgacgcaag cgcattcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaactg gcgcacttca ccagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatatagt aacaaagttg ataacccgat tgaataataa 4740
ggatccccta ggggcgcgcc tggtagtgtg gggtctcccc atgcgagagt agggaactgc 4800
caggcatcaa ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt ttatctgttg 4860
tttgtcggtg aacgctctcc tgagtaggac aaatccgccg ggagcggatt tgaacgttgc 4920
gaagcaacgg cccggagggt ggcgggcagg acgcccgcca taaactgcca ggcatcaaat 4980
taagcagaag gccatcctga cggatggcct ttttgcgttt ctacaaactc gagctcgaat 5040
tcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 5100
aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc 5160
acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg 5220
cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct 5280
tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac 5340
tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga 5400
gcaaaaggcc agcaaaagcc caggaaccgt aaaaaggccg cgttgctggc gtttttccat 5460
aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac 5520
ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct 5580
gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg 5640
ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg 5700
ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt 5760
cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg 5820
attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac 5880
ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga 5940
aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt 6000
gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt 6060
tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga 6120
ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt tagcacgtgc 6180
tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt 6240
tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgtatgc 6300
ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggaaa ttgtaagcgt 6360
taataattca gaagaactcg tcaagaaggc gatagaaggc gatgcgctgc gaatcgggag 6420
cggcgatacc gtaaagcacg aggaagcggt cagcccattc gccgccaagc tcttcagcaa 6480
tatcacgggt agccaacgct atgtcctgat agcggtccgc cacacccagc cggccacagt 6540
cgatgaatcc agaaaagcgg ccattttcca ccatgatatt cggcaagcag gcatcgccat 6600
gggtcacgac gagatcctcg ccgtcgggca tgctcgcctt gagcctggcg aacagttcgg 6660
ctggcgcgag cccctgatgc tcttcgtcca gatcatcctg atcgacaaga ccggcttcca 6720
tccgagtacg tgctcgctcg atgcgatgtt tcgcttggtg gtcgaatggg caggtagccg 6780
gatcaagcgt atgcagccgc cgcattgcat cagccatgat ggatactttc tcggcaggag 6840
caaggtgaga tgacaggaga tcctgccccg gcacttcgcc caatagcagc cagtcccttc 6900
ccgcttcagt gacaacgtcg agcacagctg cgcaaggaac gcccgtcgtg gccagccacg 6960
atagccgcgc tgcctcgtct tgcagttcat tcagggcacc ggacaggtcg gtcttgacaa 7020
aaagaaccgg gcgcccctgc gctgacagcc ggaacacggc ggcatcagag cagccgattg 7080
tctgttgtgc ccagtcatag ccgaatagcc tctccaccca agcggccgga gaacctgcgt 7140
gcaatccatc ttgttcaatc atgcgaaacg atcctcatcc tgtctcttga tcagagcttg 7200
atcccctgcg ccatcagatc cttggcggcg agaaagccat ccagtttact ttgcagggct 7260
tcccaacctt accagagggc gccccagctg gcaattccgg ttcgcttgct gtccataaaa 7320
ccgcccagta gaagcatatg                                             7340<210> 5
<211> 7340
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-176

<400> 5
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtgt ccctgccgat tgcacaacaa accgaagcgg gcgatgcgag cgccttcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaaacc gcgcacttca cgagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatactcc aacaaagttg ataacccgat tgaataataa 4740
ggatccccta ggggcgcgcc tggtagtgtg gggtctcccc atgcgagagt agggaactgc 4800
caggcatcaa ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt ttatctgttg 4860
tttgtcggtg aacgctctcc tgagtaggac aaatccgccg ggagcggatt tgaacgttgc 4920
gaagcaacgg cccggagggt ggcgggcagg acgcccgcca taaactgcca ggcatcaaat 4980
taagcagaag gccatcctga cggatggcct ttttgcgttt ctacaaactc gagctcgaat 5040
tcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 5100
aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc 5160
acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg 5220
cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct 5280
tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac 5340
tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga 5400
gcaaaaggcc agcaaaagcc caggaaccgt aaaaaggccg cgttgctggc gtttttccat 5460
aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac 5520
ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct 5580
gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg 5640
ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg 5700
ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt 5760
cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg 5820
attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac 5880
ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga 5940
aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt 6000
gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt 6060
tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga 6120
ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt tagcacgtgc 6180
tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt 6240
tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgtatgc 6300
ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggaaa ttgtaagcgt 6360
taataattca gaagaactcg tcaagaaggc gatagaaggc gatgcgctgc gaatcgggag 6420
cggcgatacc gtaaagcacg aggaagcggt cagcccattc gccgccaagc tcttcagcaa 6480
tatcacgggt agccaacgct atgtcctgat agcggtccgc cacacccagc cggccacagt 6540
cgatgaatcc agaaaagcgg ccattttcca ccatgatatt cggcaagcag gcatcgccat 6600
gggtcacgac gagatcctcg ccgtcgggca tgctcgcctt gagcctggcg aacagttcgg 6660
ctggcgcgag cccctgatgc tcttcgtcca gatcatcctg atcgacaaga ccggcttcca 6720
tccgagtacg tgctcgctcg atgcgatgtt tcgcttggtg gtcgaatggg caggtagccg 6780
gatcaagcgt atgcagccgc cgcattgcat cagccatgat ggatactttc tcggcaggag 6840
caaggtgaga tgacaggaga tcctgccccg gcacttcgcc caatagcagc cagtcccttc 6900
ccgcttcagt gacaacgtcg agcacagctg cgcaaggaac gcccgtcgtg gccagccacg 6960
atagccgcgc tgcctcgtct tgcagttcat tcagggcacc ggacaggtcg gtcttgacaa 7020
aaagaaccgg gcgcccctgc gctgacagcc ggaacacggc ggcatcagag cagccgattg 7080
tctgttgtgc ccagtcatag ccgaatagcc tctccaccca agcggccgga gaacctgcgt 7140
gcaatccatc ttgttcaatc atgcgaaacg atcctcatcc tgtctcttga tcagagcttg 7200
atcccctgcg ccatcagatc cttggcggcg agaaagccat ccagtttact ttgcagggct 7260
tcccaacctt accagagggc gccccagctg gcaattccgg ttcgcttgct gtccataaaa 7320
ccgcccagta gaagcatatg                                             7340<210> 6
<211> 7253
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-177

<400> 6
atatgaagct taattaatct ttctgcgaat tgagatgacg ccactggctg ggcgtcatcc 60
cggtttcccg ggtaaacacc accgaaaaat agttactatc ttcaaagcca cattcggtcg 120
aaatatcact gattaacagg cggctatgct ggagaagata ttgcgcatga cacactctga 180
cctgtcgcag atattgattg atggtcattc cagtctgctg gcgaaattgc tgacgcaaaa 240
cgcgctcact gcacgatgcc tcatcacaaa atttatccag cgcaaaggga cttttcaggc 300
tagccgccag ccgggtaatc agcttatcca gcaacgtttc gctggatgtt ggcggcaacg 360
aatcactggt gtaacgatgg cgattcagca acatcaccaa ctgcccgaac agcaactcag 420
ccatttcgtt agcaaacggc acatgctgac tactttcatg ctcaagctga ccgataacct 480
gccgcgcctg cgccatcccc atgctaccta agcgccagtg tggttgccct gcgctggcgt 540
taaatcccgg aatcgccccc tgccagtcaa gattcagctt cagacgctcc gggcaataaa 600
taatattctg caaaaccaga tcgttaacgg aagcgtagga gtgtttatcg tcagcatgaa 660
tgtaaaagag atcgccacgg gtaatgcgat aagggcgatc gttgagtaca tgcaggccat 720
taccgcgcca gacaatcacc agctcacaaa aatcatgtgt atgttcagca aagacatctt 780
gcggataacg gtcagccaca gcgactgcct gctggtcgct ggcaaaaaaa tcatctttga 840
gaagttttaa ctgatgcgcc accgtggcta cctcggccag agaacgaagt tgattattcg 900
caatatggcg tacaaatacg ttgagaagat tcgcgttatt gcagaaagcc atcccgtccc 960
tggcgaatat cacgcggtga ccagttaaac tctcggcgaa aaagcgtcga aaagtggtta 1020
ctgtcgctga atccacagcg ataggcgatg tcagtaacgc tggcctcgct gtggcgtagc 1080
agatgtcggg ctttcatcag tcgcaggcgg ttcaggtatc gctgaggcgt cagtcccgtt 1140
tgctgcttaa gctgccgatg tagcgtacgc agtgaaagag aaaattgatc cgccacggca 1200
tcccaattca cctcatcggc aaaatggtcc tccagccagg ccagaagcaa gttgagacgt 1260
gatgcgctgt tttccaggtt ctcctgcaaa ctgcttttac gcagcaagag cagtaattgc 1320
ataaacaaga tctcgcgact ggcggtcgag ggtaaatcat tttccccttc ctgctgttcc 1380
atctgtgcaa ccagctgtcg cacctgctgc aatacgctgt ggttaacgcg ccagtgagac 1440
ggatactgcc catccagctc ttgtggcagc aactgattca gcccggcgag aaactgaaat 1500
cgatccggcg agcgatacag cacattggtc agacacagat tatcggtatg ttcatacaga 1560
tgccgatcat gatcgcgtac gaaacagacc gtgccaccgg tgatggtata gggctgccca 1620
ttaaacacat gaatacccgt gccatgttcg acaatcacaa tttcatgaaa atcatgatga 1680
tgttcaggaa aatccgcctg cgggagccgg ggttctatcg ccacggacgc gttaccagac 1740
ggaaaaaaat ccacactatg taatacggtc atactggcct cctgatgtcg tcaacacggc 1800
gaaatagtaa tcacgaggtc aggttcttac cttaaatttt cgacggaaaa ccacgtaaaa 1860
aacgtcgatt tttcaagata cagcgtgaat tttcaggaaa tgcggtgagc atcacatcac 1920
cacaattcag caaattgtga acatcatcac gttcatcttt ccctggttgc caatggccca 1980
ttttcctgtc agtaacgaga aggtcgcgaa ttcaggcgct ttttagactg gtcgtaatga 2040
aattcaggag gatggtcgac atgaaagcca cgaaactggt tctgggtgct gttatcctgg 2100
gttccacgct gctggcgggt tgttcctcta atgcgaaaat cgatcaaggc atcaacccgt 2160
atgtgggctt tgaaatgggt tacgattggc tgggtcgtat gccgtataaa ggcagcgttg 2220
aaaatggtgc atacaaagct cagggcgtcc aactgaccgc gaaactgggt tatccgatca 2280
cggatgacct ggatatttac acccgtctgg gcggtatggt ctggcgtgca gatacgaaaa 2340
gcaacgtgta tggcaaaaat catgacaccg gtgtgtctcc ggttttcgcg ggcggtgttg 2400
aatatgccat cacgccggaa attgcaaccc gtctggaata ccagtggacc aacaatatcg 2460
gcgatgcaca cacgattggt acccgcccgg ataacggcat tccgggtatc gacgaaattc 2520
tggcggccct gccgaaaacg gatacctata aactgattct gaatggcaaa acgctgaaag 2580
gtgaaaccac gaccgaagct gttgacgcag ctaccgcgga aaaagtcttc aaacaatacg 2640
ctaacgataa tggcgtggac ggtgaatgga cctacgatga cgcgacgaaa accttcacgg 2700
tcaccgaaaa accggaagtg atcgatgcca gtgaactgac gccggcagtt acgacctata 2760
aactggtcat taacggcaaa accctgaaag gtgaaacgac cacggaagct gtggatgcag 2820
caaccgcaga aaaagttttc aaacagtacg ccaatgacaa cggtgtggac ggcgaatgga 2880
cgtacgatga cgcaacgaaa accttcacgg tgaccgaaaa accggaagtt atcgatgcct 2940
ccgaactgac cccggcagtc accacgtata aactggtgat caatggtaaa acgctgaaag 3000
gcgaaaccac gaccaaagcg gttgatgccg aaaccgcaga aaaagctttt aaacaatacg 3060
cgaatgacaa tggcgtggat ggcgtgtgga cctacgatga tgcgaccaaa acctttaccg 3120
ttaccgaata ataatctaga aggaggaaca atatgatccg cttcaaaaag accaaactga 3180
ttgcgagcat tgcgatggca ctgtgtctgt tctcccagcc ggtgatttcg ttctcaaaag 3240
atattaccga caaaaatcag tccatcgatt caggcattag ctctctgtct tataaccgta 3300
atgaagtgct ggcgtccaat ggtgacaaaa tcgaatcatt tgttccgaaa gaaggcaaaa 3360
aagccggtaa caaattcatt gtggttgaac gtcagaaacg ctctctgacc acgagtccgg 3420
ttgatatctc cattatcgat tcagtcaatg accgtaccta tccgggtgca ctgcaactgg 3480
cagacaaagc atttgtggaa aaccgtccga cgattctgat ggttaaacgc aaaccgatta 3540
acatcaatat tgatctgccg ggcctgaaag gtgaaaatag tatcaaagtg gatgacccga 3600
cctatggcaa agtttcgggt gcaattgatg aactggtcag caaatggaac gaaaaataca 3660
gttccaccca tacgctgccg gcgcgtaccc agtattcgga aagcatggtg tactctaaaa 3720
gtcaaatctc atcggcgctg aacgttaatg ccaaagtcct ggaaaactct ctgggtgtgg 3780
attttaatgc ggttgccaac aatgagaaaa aagtgatgat cctggcatat aaacagattt 3840
tctacaccgt tagtgctgat ctgccgaaaa acccgtctga cctgtttgat gacagtgtca 3900
cgttcaacga tctgaaacaa aaaggcgtgt ctaatgaagc gccgccgctg atggtgtcta 3960
acgttgccta tggtcgtacc atttacgtta aactggaaac cacgagctct agtaaagatg 4020
tccaggcggc ctttaaagcc ctgatcaaaa acaccgatat caaaaatagc cagcaataca 4080
aagacatcta cgaaaattcc tcattcaccg cagtcgtgct gggcggtgat gctcaggaac 4140
acaacaaagt tgtcacgaaa gattttgacg aaatccgcaa agtgattaaa gataacgcaa 4200
ccttctcgac gaaaaatccg gcttatccga tttcgtacac cagcgttttt ctgaaagata 4260
acagcgtcgc agctgtgcat aataaaaccg actatatcga aaccaccagc accgaataca 4320
gcaaaggcaa aattaatctg gatcactccg gtgcatatgt cgctcagttc gaagtggcct 4380
gggatgaagt ttcatacgac aaagaaggca atgaagtgct gacccataaa acgtgggatg 4440
gtaactatca agacaaaacc gcacactact ccacggttat tccgctggaa gcaaacgctc 4500
gtaatatccg cattaaagcg cgtgaatgca ccggtctggc atgggaatgg tggcgtgatg 4560
tcatcagcga atatgacgtg ccgctgacga acaatatcaa tgtgtcaatc tggggcacca 4620
cgctgtatcc gggtagttcc atcacctata attaataagg atcccctagg ggcgcgcctg 4680
gtagtgtggg gtctccccat gcgagagtag ggaactgcca ggcatcaaat aaaacgaaag 4740
gctcagtcga aagactgggc ctttcgtttt atctgttgtt tgtcggtgaa cgctctcctg 4800
agtaggacaa atccgccggg agcggatttg aacgttgcga agcaacggcc cggagggtgg 4860
cgggcaggac gcccgccata aactgccagg catcaaatta agcagaaggc catcctgacg 4920
gatggccttt ttgcgtttct acaaactcga gctcgaattc gtaatcatgg tcatagctgt 4980
ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa 5040
agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac 5100
tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg 5160
cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact gactcgctgc 5220
gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat 5280
ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaagccca 5340
ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc 5400
atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc 5460
aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg 5520
gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta 5580
ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg 5640
ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac 5700
acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag 5760
gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga aggacagtat 5820
ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat 5880
ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc 5940
gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt 6000
ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct 6060
agatcctttt aaattaaaaa tgaagtttta gcacgtgcta ttattgaagc atttatcagg 6120
gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg 6180
ttccgcgcac atttccccga aaagtgccac ctgtatgcgg tgtgaaatac cgcacagatg 6240
cgtaaggaga aaataccgca tcaggaaatt gtaagcgtta ataattcaga agaactcgtc 6300
aagaaggcga tagaaggcga tgcgctgcga atcgggagcg gcgataccgt aaagcacgag 6360
gaagcggtca gcccattcgc cgccaagctc ttcagcaata tcacgggtag ccaacgctat 6420
gtcctgatag cggtccgcca cacccagccg gccacagtcg atgaatccag aaaagcggcc 6480
attttccacc atgatattcg gcaagcaggc atcgccatgg gtcacgacga gatcctcgcc 6540
gtcgggcatg ctcgccttga gcctggcgaa cagttcggct ggcgcgagcc cctgatgctc 6600
ttcgtccaga tcatcctgat cgacaagacc ggcttccatc cgagtacgtg ctcgctcgat 6660
gcgatgtttc gcttggtggt cgaatgggca ggtagccgga tcaagcgtat gcagccgccg 6720
cattgcatca gccatgatgg atactttctc ggcaggagca aggtgagatg acaggagatc 6780
ctgccccggc acttcgccca atagcagcca gtcccttccc gcttcagtga caacgtcgag 6840
cacagctgcg caaggaacgc ccgtcgtggc cagccacgat agccgcgctg cctcgtcttg 6900
cagttcattc agggcaccgg acaggtcggt cttgacaaaa agaaccgggc gcccctgcgc 6960
tgacagccgg aacacggcgg catcagagca gccgattgtc tgttgtgccc agtcatagcc 7020
gaatagcctc tccacccaag cggccggaga acctgcgtgc aatccatctt gttcaatcat 7080
gcgaaacgat cctcatcctg tctcttgatc agagcttgat cccctgcgcc atcagatcct 7140
tggcggcgag aaagccatcc agtttacttt gcagggcttc ccaaccttac cagagggcgc 7200
cccagctggc aattccggtt cgcttgctgt ccataaaacc gcccagtaga agc        7253<210> 7
<211> 6398
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-199

<400> 7
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaggatc caggaggaac aatatgtccc gcaaactgtt cgctagtatt 3180
ctgattggtg ctctgctggg tatcggtgct ccgccgtctg ctcacgctgg tgctgatgac 3240
gtggttgaca gctctaaatc ttttgttatg gaaaacttca gttcctatca tggcaccaaa 3300
ccgggttacg tcgattcgat tcagaaaggc atccaaaaac cgaaaagcgg cacccagggt 3360
aactatgatg acgattggaa aggtttctac tcaacggaca acaaatacga tgcggccggc 3420
tactccgtgg acaacgaaaa tccgctgagc ggtaaagcag gcggtgtcgt gaaagttacc 3480
tatccgggcc tgacgaaagt gctggcgctg aaagttgata acgccgaaac catcaaaaaa 3540
gaactgggcc tgtccctgac cgaaccgctg atggaacaag tgggtacgga agaatttatc 3600
aaacgtttcg gcgatggtgc atctcgcgtt gtcctgagtc tgccgtttgc tgaaggctca 3660
tcgagcgtcg aatacattaa caattgggaa caagcaaaag ctctgagcgt ggaactggaa 3720
atcaatttcg aaacgcgtgg taaacgtggt caagatgcaa tgtatgaata tatggctcaa 3780
gcgtgtgcgg gtaaccgtgt tcgctaataa ggcgcgcctg gtagtgtggg gtctccccat 3840
gcgagagtag ggaactgcca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc 3900
ctttcgtttt atctgttgtt tgtcggtgaa cgctctcctg agtaggacaa atccgccggg 3960
agcggatttg aacgttgcga agcaacggcc cggagggtgg cgggcaggac gcccgccata 4020
aactgccagg catcaaatta agcagaaggc catcctgacg gatggccttt ttgcgtttct 4080
acaaactcga gctcgaattc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat 4140
ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc 4200
taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga 4260
aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt 4320
attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg 4380
cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac 4440
gcaggaaaga acatgtgagc aaaaggccag caaaagccca ggaaccgtaa aaaggccgcg 4500
ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca 4560
agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc 4620
tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc 4680
ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag 4740
gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc 4800
ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca 4860
gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg 4920
aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg 4980
aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct 5040
ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa 5100
gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa 5160
gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa 5220
tgaagtttta gcacgtgcta ttattgaagc atttatcagg gttattgtct catgagcgga 5280
tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga 5340
aaagtgccac ctgtatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca 5400
tcaggaaatt gtaagcgtta ataattcaga agaactcgtc aagaaggcga tagaaggcga 5460
tgcgctgcga atcgggagcg gcgataccgt aaagcacgag gaagcggtca gcccattcgc 5520
cgccaagctc ttcagcaata tcacgggtag ccaacgctat gtcctgatag cggtccgcca 5580
cacccagccg gccacagtcg atgaatccag aaaagcggcc attttccacc atgatattcg 5640
gcaagcaggc atcgccatgg gtcacgacga gatcctcgcc gtcgggcatg ctcgccttga 5700
gcctggcgaa cagttcggct ggcgcgagcc cctgatgctc ttcgtccaga tcatcctgat 5760
cgacaagacc ggcttccatc cgagtacgtg ctcgctcgat gcgatgtttc gcttggtggt 5820
cgaatgggca ggtagccgga tcaagcgtat gcagccgccg cattgcatca gccatgatgg 5880
atactttctc ggcaggagca aggtgagatg acaggagatc ctgccccggc acttcgccca 5940
atagcagcca gtcccttccc gcttcagtga caacgtcgag cacagctgcg caaggaacgc 6000
ccgtcgtggc cagccacgat agccgcgctg cctcgtcttg cagttcattc agggcaccgg 6060
acaggtcggt cttgacaaaa agaaccgggc gcccctgcgc tgacagccgg aacacggcgg 6120
catcagagca gccgattgtc tgttgtgccc agtcatagcc gaatagcctc tccacccaag 6180
cggccggaga acctgcgtgc aatccatctt gttcaatcat gcgaaacgat cctcatcctg 6240
tctcttgatc agagcttgat cccctgcgcc atcagatcct tggcggcgag aaagccatcc 6300
agtttacttt gcagggcttc ccaaccttac cagagggcgc cccagctggc aattccggtt 6360
cgcttgctgt ccataaaacc gcccagtaga agcatatg                         6398<210> 8
<211> 6326
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-198

<400> 8
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaggatc caggaggaac aatatgggcg cagacgacgt tgttgacagc 3180
agcaaatctt tcgttatgga aaacttcagc agctatcacg gcaccaaacc gggctatgtg 3240
gactctattc agaaaggcat ccaaaaaccg aaaagtggca cccagggtaa ctatgatgac 3300
gattggaaag gtttttactc cacggacaat aaatatgatg cggccggcta ctcggtcgac 3360
aacgaaaatc cgctgagcgg taaagcaggc ggtgtggtta aagttaccta tccgggcctg 3420
acgaaagttc tggcgctgaa agtcgataac gccgaaacca tcaaaaaaga actgggcctg 3480
tcactgaccg aaccgctgat ggaacaagtg ggtacggaag aatttatcaa acgtttcggc 3540
gatggtgcat cccgcgtcgt gctgtcactg ccgtttgctg aaggcagctc tagtgtggaa 3600
tacattaaca attgggaaca agcaaaagct ctgagcgttg aactggaaat caatttcgaa 3660
acgcgtggta aacgtggtca agatgcgatg tatgaatata tggctcaagc gtgtgcgggt 3720
aaccgtgtgc gttaataagg cgcgcctggt agtgtggggt ctccccatgc gagagtaggg 3780
aactgccagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat 3840
ctgttgtttg tcggtgaacg ctctcctgag taggacaaat ccgccgggag cggatttgaa 3900
cgttgcgaag caacggcccg gagggtggcg ggcaggacgc ccgccataaa ctgccaggca 3960
tcaaattaag cagaaggcca tcctgacgga tggccttttt gcgtttctac aaactcgagc 4020
tcgaattcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt 4080
ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc 4140
taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc 4200
cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct 4260
tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca 4320
gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac 4380
atgtgagcaa aaggccagca aaagcccagg aaccgtaaaa aggccgcgtt gctggcgttt 4440
ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg 4500
cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc 4560
tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc 4620
gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc 4680
aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac 4740
tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt 4800
aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct 4860
aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc 4920
ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt 4980
ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg 5040
atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc 5100
atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttagc 5160
acgtgctatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa 5220
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct 5280
gtatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc aggaaattgt 5340
aagcgttaat aattcagaag aactcgtcaa gaaggcgata gaaggcgatg cgctgcgaat 5400
cgggagcggc gataccgtaa agcacgagga agcggtcagc ccattcgccg ccaagctctt 5460
cagcaatatc acgggtagcc aacgctatgt cctgatagcg gtccgccaca cccagccggc 5520
cacagtcgat gaatccagaa aagcggccat tttccaccat gatattcggc aagcaggcat 5580
cgccatgggt cacgacgaga tcctcgccgt cgggcatgct cgccttgagc ctggcgaaca 5640
gttcggctgg cgcgagcccc tgatgctctt cgtccagatc atcctgatcg acaagaccgg 5700
cttccatccg agtacgtgct cgctcgatgc gatgtttcgc ttggtggtcg aatgggcagg 5760
tagccggatc aagcgtatgc agccgccgca ttgcatcagc catgatggat actttctcgg 5820
caggagcaag gtgagatgac aggagatcct gccccggcac ttcgcccaat agcagccagt 5880
cccttcccgc ttcagtgaca acgtcgagca cagctgcgca aggaacgccc gtcgtggcca 5940
gccacgatag ccgcgctgcc tcgtcttgca gttcattcag ggcaccggac aggtcggtct 6000
tgacaaaaag aaccgggcgc ccctgcgctg acagccggaa cacggcggca tcagagcagc 6060
cgattgtctg ttgtgcccag tcatagccga atagcctctc cacccaagcg gccggagaac 6120
ctgcgtgcaa tccatcttgt tcaatcatgc gaaacgatcc tcatcctgtc tcttgatcag 6180
agcttgatcc cctgcgccat cagatccttg gcggcgagaa agccatccag tttactttgc 6240
agggcttccc aaccttacca gagggcgccc cagctggcaa ttccggttcg cttgctgtcc 6300
ataaaaccgc ccagtagaag catatg                                      6326<210> 9
<211> 6517
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-200

<400> 9
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaggatc caggaggatt actatatggg tctggatacc gtgagcttct 3180
cgacgaaagg cgcaacctac attacctacg tgaacttcct gaacgaactg cgtgtgaaac 3240
tgaaaccgga aggcaacagc catggtatcc cgctgctgcg taaaaaatgc gatgacccgg 3300
gcaaatgttt tgttctggtc gcactgagta acgataatgg tcagctggca gaaattgcta 3360
tcgacgtgac ctcagtttat gtggttggct accaagtccg taaccgctcg tatttcttta 3420
aagatgcacc ggacgcggcc tacgaaggtc tgtttaaaaa taccatcaaa acgcgcctgc 3480
acttcggcgg tagttatccg tccctggaag gcgaaaaagc gtatcgtgaa accacggatc 3540
tgggcattga accgctgcgc attggtatca aaaaactgga tgaaaacgcg attgacaatt 3600
ataaaccgac ggaaatcgcc agctctctgc tggtcgtgat tcagatggtg tcagaagccg 3660
ctcgttttac ctttatcgaa aatcaaatcc gcaacaactt tcaacaaaga attcgcccgg 3720
ctaataatac gatctcgctg gaaaataaat ggggtaaact gagctttcaa atccgcacct 3780
cgggcgctaa cggcatgttc tccgaagcgg tggaactgga acgtgccaac ggcaaaaaat 3840
attacgttac cgctgtggac caggtgaaac cgaaaatcgc tctgctgaaa ttcgttgata 3900
aagacccgaa ataataagga tcccctaggg gcgcgcctgg tagtgtgggg tctccccatg 3960
cgagagtagg gaactgccag gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc 4020
tttcgtttta tctgttgttt gtcggtgaac gctctcctga gtaggacaaa tccgccggga 4080
gcggatttga acgttgcgaa gcaacggccc ggagggtggc gggcaggacg cccgccataa 4140
actgccaggc atcaaattaa gcagaaggcc atcctgacgg atggcctttt tgcgtttcta 4200
caaactcgag ctcgaattcg taatcatggt catagctgtt tcctgtgtga aattgttatc 4260
cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct 4320
aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa 4380
acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta 4440
ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc 4500
gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg 4560
caggaaagaa catgtgagca aaaggccagc aaaagcccag gaaccgtaaa aaggccgcgt 4620
tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 4680
gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 4740
ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 4800
cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg 4860
tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 4920
tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 4980
cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 5040
agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga 5100
agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 5160
gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 5220
aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 5280
ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 5340
gaagttttag cacgtgctat tattgaagca tttatcaggg ttattgtctc atgagcggat 5400
acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa 5460
aagtgccacc tgtatgcggt gtgaaatacc gcacagatgc gtaaggagaa aataccgcat 5520
caggaaattg taagcgttaa taattcagaa gaactcgtca agaaggcgat agaaggcgat 5580
gcgctgcgaa tcgggagcgg cgataccgta aagcacgagg aagcggtcag cccattcgcc 5640
gccaagctct tcagcaatat cacgggtagc caacgctatg tcctgatagc ggtccgccac 5700
acccagccgg ccacagtcga tgaatccaga aaagcggcca ttttccacca tgatattcgg 5760
caagcaggca tcgccatggg tcacgacgag atcctcgccg tcgggcatgc tcgccttgag 5820
cctggcgaac agttcggctg gcgcgagccc ctgatgctct tcgtccagat catcctgatc 5880
gacaagaccg gcttccatcc gagtacgtgc tcgctcgatg cgatgtttcg cttggtggtc 5940
gaatgggcag gtagccggat caagcgtatg cagccgccgc attgcatcag ccatgatgga 6000
tactttctcg gcaggagcaa ggtgagatga caggagatcc tgccccggca cttcgcccaa 6060
tagcagccag tcccttcccg cttcagtgac aacgtcgagc acagctgcgc aaggaacgcc 6120
cgtcgtggcc agccacgata gccgcgctgc ctcgtcttgc agttcattca gggcaccgga 6180
caggtcggtc ttgacaaaaa gaaccgggcg cccctgcgct gacagccgga acacggcggc 6240
atcagagcag ccgattgtct gttgtgccca gtcatagccg aatagcctct ccacccaagc 6300
ggccggagaa cctgcgtgca atccatcttg ttcaatcatg cgaaacgatc ctcatcctgt 6360
ctcttgatca gagcttgatc ccctgcgcca tcagatcctt ggcggcgaga aagccatcca 6420
gtttactttg cagggcttcc caaccttacc agagggcgcc ccagctggca attccggttc 6480
gcttgctgtc cataaaaccg cccagtagaa gcatatg                          6517<210> 10
<211> 7965
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-195

<400> 10
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagagctga ggagggattg agcgatgtct gcattcaata aagaaaattc 3180
aatttcatcc atggcaccac cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa 3240
gaaacacgcg gatgaaatcg ataagtatat acaaggattg gattacaata aaaacaatgt 3300
attagtatac cacggagatg cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg 3360
aaatgaatat attgttgtgg agaaaaagaa gaaatccatc aatcaaaata atgcagacat 3420
tcaagttgtg aatgcaattt cgagcctaac ctatccaggt gctctcgtaa aagcgaattc 3480
ggaattagta gaaaatcaac cagatgttct ccctgtaaaa cgtgattcat taacactcag 3540
cattgatttg ccaggtatga ctaatcaaga caataaaata gttgtaaaaa atgccactaa 3600
atcaaacgtt aacaacgcag taaatacatt agtggaaaga tggaatgaaa aatatgctca 3660
agcttatcca aatgtaagtg caaaaattga ttatgatgac gaaatggctt acagtgaatc 3720
acaattaatt gcgaaatttg gtacagcatt taaagctgta aataatagct tgaatgtaaa 3780
cttcggcgca atcagtgaag ggaaaatgca agaagaagtc attagtttta aacaaattta 3840
ctataacgtg aatgttaatg aacctacaag accttccaga tttttcggca aagctgttac 3900
taaagagcag ttgcaagcgc ttggagtgaa tgcagaaaat cctcctgcat atatctcaag 3960
tgtggcgtat ggccgtcaag tttatttgaa attatcaact aattcccata gtactaaagt 4020
aaaagctgct tttgatgctg ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac 4080
aaatatcatc aaaaattctt ccttcaaagc cgtaatttac ggaggttccg caaaagatga 4140
agttcaaatc atcgacggca acctcggaga cttacgcgat attttgaaaa aaggcgctac 4200
ttttaatcga gaaacaccag gagttcccat tgcttataca acaaacttcc taaaagacaa 4260
tgaattagct gttattaaaa acaactcaga atatattgaa acaacttcaa aagcttatac 4320
agatggaaaa attaacatcg atcactctgg aggatacgtt gctcaattca acatttcttg 4380
ggatgaagta aattatgatc ctgaaggtaa cgaaattgtt caacataaaa actggagcga 4440
aaacaataaa agcaagctag ctcatttcac atcgtccatc tatttgcctg gtaacgcgag 4500
aaatattaat gtttacgcta aagaatgcac tggtttagct tgggaatggt ggagaacggt 4560
aattgatgac cggaacttac cacttgtgaa aaatagaaat atctccatct ggggcaccac 4620
gctttatccg aaatatagta ataaagtaga taatccaatc gaatatgatt ataaagatga 4680
cgatgacaaa taataatcta gaggatccag gaggaacaat atgtcccgca aactgttcgc 4740
tagtattctg attggtgctc tgctgggtat cggtgctccg ccgtctgctc acgctggtgc 4800
tgatgacgtg gttgacagct ctaaatcttt tgttatggaa aacttcagtt cctatcatgg 4860
caccaaaccg ggttacgtcg attcgattca gaaaggcatc caaaaaccga aaagcggcac 4920
ccagggtaac tatgatgacg attggaaagg tttctactca acggacaaca aatacgatgc 4980
ggccggctac tccgtggaca acgaaaatcc gctgagcggt aaagcaggcg gtgtcgtgaa 5040
agttacctat ccgggcctga cgaaagtgct ggcgctgaaa gttgataacg ccgaaaccat 5100
caaaaaagaa ctgggcctgt ccctgaccga accgctgatg gaacaagtgg gtacggaaga 5160
atttatcaaa cgtttcggcg atggtgcatc tcgcgttgtc ctgagtctgc cgtttgctga 5220
aggctcatcg agcgtcgaat acattaacaa ttgggaacaa gcaaaagctc tgagcgtgga 5280
actggaaatc aatttcgaaa cgcgtggtaa acgtggtcaa gatgcaatgt atgaatatat 5340
ggctcaagcg tgtgcgggta accgtgttcg ctaataaggc gcgcctggta gtgtggggtc 5400
tccccatgcg agagtaggga actgccaggc atcaaataaa acgaaaggct cagtcgaaag 5460
actgggcctt tcgttttatc tgttgtttgt cggtgaacgc tctcctgagt aggacaaatc 5520
cgccgggagc ggatttgaac gttgcgaagc aacggcccgg agggtggcgg gcaggacgcc 5580
cgccataaac tgccaggcat caaattaagc agaaggccat cctgacggat ggcctttttg 5640
cgtttctaca aactcgagct cgaattcgta atcatggtca tagctgtttc ctgtgtgaaa 5700
ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg 5760
gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca 5820
gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg 5880
tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg 5940
gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg 6000
ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aagcccagga accgtaaaaa 6060
ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg 6120
acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc 6180
tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc 6240
ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc 6300
ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg 6360
ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc 6420
actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga 6480
gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc 6540
tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac 6600
caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg 6660
atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc 6720
acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa 6780
ttaaaaatga agttttagca cgtgctatta ttgaagcatt tatcagggtt attgtctcat 6840
gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt 6900
tccccgaaaa gtgccacctg tatgcggtgt gaaataccgc acagatgcgt aaggagaaaa 6960
taccgcatca ggaaattgta agcgttaata attcagaaga actcgtcaag aaggcgatag 7020
aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa gcacgaggaa gcggtcagcc 7080
cattcgccgc caagctcttc agcaatatca cgggtagcca acgctatgtc ctgatagcgg 7140
tccgccacac ccagccggcc acagtcgatg aatccagaaa agcggccatt ttccaccatg 7200
atattcggca agcaggcatc gccatgggtc acgacgagat cctcgccgtc gggcatgctc 7260
gccttgagcc tggcgaacag ttcggctggc gcgagcccct gatgctcttc gtccagatca 7320
tcctgatcga caagaccggc ttccatccga gtacgtgctc gctcgatgcg atgtttcgct 7380
tggtggtcga atgggcaggt agccggatca agcgtatgca gccgccgcat tgcatcagcc 7440
atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg ccccggcact 7500
tcgcccaata gcagccagtc ccttcccgct tcagtgacaa cgtcgagcac agctgcgcaa 7560
ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct cgtcttgcag ttcattcagg 7620
gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc cctgcgctga cagccggaac 7680
acggcggcat cagagcagcc gattgtctgt tgtgcccagt catagccgaa tagcctctcc 7740
acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt caatcatgcg aaacgatcct 7800
catcctgtct cttgatcaga gcttgatccc ctgcgccatc agatccttgg cggcgagaaa 7860
gccatccagt ttactttgca gggcttccca accttaccag agggcgcccc agctggcaat 7920
tccggttcgc ttgctgtcca taaaaccgcc cagtagaagc atatg                 7965<210> 11
<211> 8003
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-180

<400> 11
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtct ctctgccgat tgctcaacaa acggaagctg gcgacgcaag cgcattcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaactg gcgcacttca ccagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatatagt aacaaagttg ataacccgat tgaataataa 4740
ggatccagga ggaacaatat gtcccgcaaa ctgttcgcta gtattctgat tggtgctctg 4800
ctgggtatcg gtgctccgcc gtctgctcac gctggtgctg atgacgtggt tgacagctct 4860
aaatcttttg ttatggaaaa cttcagttcc tatcatggca ccaaaccggg ttacgtcgat 4920
tcgattcaga aaggcatcca aaaaccgaaa agcggcaccc agggtaacta tgatgacgat 4980
tggaaaggtt tctactcaac ggacaacaaa tacgatgcgg ccggctactc cgtggacaac 5040
gaaaatccgc tgagcggtaa agcaggcggt gtcgtgaaag ttacctatcc gggcctgacg 5100
aaagtgctgg cgctgaaagt tgataacgcc gaaaccatca aaaaagaact gggcctgtcc 5160
ctgaccgaac cgctgatgga acaagtgggt acggaagaat ttatcaaacg tttcggcgat 5220
ggtgcatctc gcgttgtcct gagtctgccg tttgctgaag gctcatcgag cgtcgaatac 5280
attaacaatt gggaacaagc aaaagctctg agcgtggaac tggaaatcaa tttcgaaacg 5340
cgtggtaaac gtggtcaaga tgcaatgtat gaatatatgg ctcaagcgtg tgcgggtaac 5400
cgtgttcgct aataaggcgc gcctggtagt gtggggtctc cccatgcgag agtagggaac 5460
tgccaggcat caaataaaac gaaaggctca gtcgaaagac tgggcctttc gttttatctg 5520
ttgtttgtcg gtgaacgctc tcctgagtag gacaaatccg ccgggagcgg atttgaacgt 5580
tgcgaagcaa cggcccggag ggtggcgggc aggacgcccg ccataaactg ccaggcatca 5640
aattaagcag aaggccatcc tgacggatgg cctttttgcg tttctacaaa ctcgagctcg 5700
aattcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca 5760
cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa 5820
ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag 5880
ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc 5940
gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct 6000
cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg 6060
tgagcaaaag gccagcaaaa gcccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc 6120
cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga 6180
aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct 6240
cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg 6300
gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag 6360
ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat 6420
cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac 6480
aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac 6540
tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc 6600
ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt 6660
tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc 6720
ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg 6780
agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttagcacg 6840
tgctattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt 6900
atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgta 6960
tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg aaattgtaag 7020
cgttaataat tcagaagaac tcgtcaagaa ggcgatagaa ggcgatgcgc tgcgaatcgg 7080
gagcggcgat accgtaaagc acgaggaagc ggtcagccca ttcgccgcca agctcttcag 7140
caatatcacg ggtagccaac gctatgtcct gatagcggtc cgccacaccc agccggccac 7200
agtcgatgaa tccagaaaag cggccatttt ccaccatgat attcggcaag caggcatcgc 7260
catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc cttgagcctg gcgaacagtt 7320
cggctggcgc gagcccctga tgctcttcgt ccagatcatc ctgatcgaca agaccggctt 7380
ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg gtggtcgaat gggcaggtag 7440
ccggatcaag cgtatgcagc cgccgcattg catcagccat gatggatact ttctcggcag 7500
gagcaaggtg agatgacagg agatcctgcc ccggcacttc gcccaatagc agccagtccc 7560
ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg aacgcccgtc gtggccagcc 7620
acgatagccg cgctgcctcg tcttgcagtt cattcagggc accggacagg tcggtcttga 7680
caaaaagaac cgggcgcccc tgcgctgaca gccggaacac ggcggcatca gagcagccga 7740
ttgtctgttg tgcccagtca tagccgaata gcctctccac ccaagcggcc ggagaacctg 7800
cgtgcaatcc atcttgttca atcatgcgaa acgatcctca tcctgtctct tgatcagagc 7860
ttgatcccct gcgccatcag atccttggcg gcgagaaagc catccagttt actttgcagg 7920
gcttcccaac cttaccagag ggcgccccag ctggcaattc cggttcgctt gctgtccata 7980
aaaccgccca gtagaagcat atg                                         8003<210> 12
<211> 8003
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-192

<400> 12
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtgt ccctgccgat tgcacaacaa accgaagcgg gcgatgcgag cgccttcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaaacc gcgcacttca cgagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatactcc aacaaagttg ataacccgat tgaataataa 4740
ggatccagga ggaacaatat gtcccgcaaa ctgttcgcta gtattctgat tggtgctctg 4800
ctgggtatcg gtgctccgcc gtctgctcac gctggtgctg atgacgtggt tgacagctct 4860
aaatcttttg ttatggaaaa cttcagttcc tatcatggca ccaaaccggg ttacgtcgat 4920
tcgattcaga aaggcatcca aaaaccgaaa agcggcaccc agggtaacta tgatgacgat 4980
tggaaaggtt tctactcaac ggacaacaaa tacgatgcgg ccggctactc cgtggacaac 5040
gaaaatccgc tgagcggtaa agcaggcggt gtcgtgaaag ttacctatcc gggcctgacg 5100
aaagtgctgg cgctgaaagt tgataacgcc gaaaccatca aaaaagaact gggcctgtcc 5160
ctgaccgaac cgctgatgga acaagtgggt acggaagaat ttatcaaacg tttcggcgat 5220
ggtgcatctc gcgttgtcct gagtctgccg tttgctgaag gctcatcgag cgtcgaatac 5280
attaacaatt gggaacaagc aaaagctctg agcgtggaac tggaaatcaa tttcgaaacg 5340
cgtggtaaac gtggtcaaga tgcaatgtat gaatatatgg ctcaagcgtg tgcgggtaac 5400
cgtgttcgct aataaggcgc gcctggtagt gtggggtctc cccatgcgag agtagggaac 5460
tgccaggcat caaataaaac gaaaggctca gtcgaaagac tgggcctttc gttttatctg 5520
ttgtttgtcg gtgaacgctc tcctgagtag gacaaatccg ccgggagcgg atttgaacgt 5580
tgcgaagcaa cggcccggag ggtggcgggc aggacgcccg ccataaactg ccaggcatca 5640
aattaagcag aaggccatcc tgacggatgg cctttttgcg tttctacaaa ctcgagctcg 5700
aattcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca 5760
cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa 5820
ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag 5880
ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc 5940
gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct 6000
cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg 6060
tgagcaaaag gccagcaaaa gcccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc 6120
cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga 6180
aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct 6240
cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg 6300
gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag 6360
ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat 6420
cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac 6480
aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac 6540
tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc 6600
ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt 6660
tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc 6720
ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg 6780
agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttagcacg 6840
tgctattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt 6900
atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgta 6960
tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg aaattgtaag 7020
cgttaataat tcagaagaac tcgtcaagaa ggcgatagaa ggcgatgcgc tgcgaatcgg 7080
gagcggcgat accgtaaagc acgaggaagc ggtcagccca ttcgccgcca agctcttcag 7140
caatatcacg ggtagccaac gctatgtcct gatagcggtc cgccacaccc agccggccac 7200
agtcgatgaa tccagaaaag cggccatttt ccaccatgat attcggcaag caggcatcgc 7260
catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc cttgagcctg gcgaacagtt 7320
cggctggcgc gagcccctga tgctcttcgt ccagatcatc ctgatcgaca agaccggctt 7380
ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg gtggtcgaat gggcaggtag 7440
ccggatcaag cgtatgcagc cgccgcattg catcagccat gatggatact ttctcggcag 7500
gagcaaggtg agatgacagg agatcctgcc ccggcacttc gcccaatagc agccagtccc 7560
ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg aacgcccgtc gtggccagcc 7620
acgatagccg cgctgcctcg tcttgcagtt cattcagggc accggacagg tcggtcttga 7680
caaaaagaac cgggcgcccc tgcgctgaca gccggaacac ggcggcatca gagcagccga 7740
ttgtctgttg tgcccagtca tagccgaata gcctctccac ccaagcggcc ggagaacctg 7800
cgtgcaatcc atcttgttca atcatgcgaa acgatcctca tcctgtctct tgatcagagc 7860
ttgatcccct gcgccatcag atccttggcg gcgagaaagc catccagttt actttgcagg 7920
gcttcccaac cttaccagag ggcgccccag ctggcaattc cggttcgctt gctgtccata 7980
aaaccgccca gtagaagcat atg                                         8003<210> 13
<211> 7916
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-184

<400> 13
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg atccgcttca aaaagaccaa actgattgcg 3180
agcattgcga tggcactgtg tctgttctcc cagccggtga tttcgttctc aaaagatatt 3240
accgacaaaa atcagtccat cgattcaggc attagctctc tgtcttataa ccgtaatgaa 3300
gtgctggcgt ccaatggtga caaaatcgaa tcatttgttc cgaaagaagg caaaaaagcc 3360
ggtaacaaat tcattgtggt tgaacgtcag aaacgctctc tgaccacgag tccggttgat 3420
atctccatta tcgattcagt caatgaccgt acctatccgg gtgcactgca actggcagac 3480
aaagcatttg tggaaaaccg tccgacgatt ctgatggtta aacgcaaacc gattaacatc 3540
aatattgatc tgccgggcct gaaaggtgaa aatagtatca aagtggatga cccgacctat 3600
ggcaaagttt cgggtgcaat tgatgaactg gtcagcaaat ggaacgaaaa atacagttcc 3660
acccatacgc tgccggcgcg tacccagtat tcggaaagca tggtgtactc taaaagtcaa 3720
atctcatcgg cgctgaacgt taatgccaaa gtcctggaaa actctctggg tgtggatttt 3780
aatgcggttg ccaacaatga gaaaaaagtg atgatcctgg catataaaca gattttctac 3840
accgttagtg ctgatctgcc gaaaaacccg tctgacctgt ttgatgacag tgtcacgttc 3900
aacgatctga aacaaaaagg cgtgtctaat gaagcgccgc cgctgatggt gtctaacgtt 3960
gcctatggtc gtaccattta cgttaaactg gaaaccacga gctctagtaa agatgtccag 4020
gcggccttta aagccctgat caaaaacacc gatatcaaaa atagccagca atacaaagac 4080
atctacgaaa attcctcatt caccgcagtc gtgctgggcg gtgatgctca ggaacacaac 4140
aaagttgtca cgaaagattt tgacgaaatc cgcaaagtga ttaaagataa cgcaaccttc 4200
tcgacgaaaa atccggctta tccgatttcg tacaccagcg tttttctgaa agataacagc 4260
gtcgcagctg tgcataataa aaccgactat atcgaaacca ccagcaccga atacagcaaa 4320
ggcaaaatta atctggatca ctccggtgca tatgtcgctc agttcgaagt ggcctgggat 4380
gaagtttcat acgacaaaga aggcaatgaa gtgctgaccc ataaaacgtg ggatggtaac 4440
tatcaagaca aaaccgcaca ctactccacg gttattccgc tggaagcaaa cgctcgtaat 4500
atccgcatta aagcgcgtga atgcaccggt ctggcatggg aatggtggcg tgatgtcatc 4560
agcgaatatg acgtgccgct gacgaacaat atcaatgtgt caatctgggg caccacgctg 4620
tatccgggta gttccatcac ctataattaa taaggatcca ggaggaacaa tatgtcccgc 4680
aaactgttcg ctagtattct gattggtgct ctgctgggta tcggtgctcc gccgtctgct 4740
cacgctggtg ctgatgacgt ggttgacagc tctaaatctt ttgttatgga aaacttcagt 4800
tcctatcatg gcaccaaacc gggttacgtc gattcgattc agaaaggcat ccaaaaaccg 4860
aaaagcggca cccagggtaa ctatgatgac gattggaaag gtttctactc aacggacaac 4920
aaatacgatg cggccggcta ctccgtggac aacgaaaatc cgctgagcgg taaagcaggc 4980
ggtgtcgtga aagttaccta tccgggcctg acgaaagtgc tggcgctgaa agttgataac 5040
gccgaaacca tcaaaaaaga actgggcctg tccctgaccg aaccgctgat ggaacaagtg 5100
ggtacggaag aatttatcaa acgtttcggc gatggtgcat ctcgcgttgt cctgagtctg 5160
ccgtttgctg aaggctcatc gagcgtcgaa tacattaaca attgggaaca agcaaaagct 5220
ctgagcgtgg aactggaaat caatttcgaa acgcgtggta aacgtggtca agatgcaatg 5280
tatgaatata tggctcaagc gtgtgcgggt aaccgtgttc gctaataagg cgcgcctggt 5340
agtgtggggt ctccccatgc gagagtaggg aactgccagg catcaaataa aacgaaaggc 5400
tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag 5460
taggacaaat ccgccgggag cggatttgaa cgttgcgaag caacggcccg gagggtggcg 5520
ggcaggacgc ccgccataaa ctgccaggca tcaaattaag cagaaggcca tcctgacgga 5580
tggccttttt gcgtttctac aaactcgagc tcgaattcgt aatcatggtc atagctgttt 5640
cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag 5700
tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg 5760
cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg 5820
gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc 5880
tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc 5940
acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaagcccagg 6000
aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat 6060
cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag 6120
gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga 6180
tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg 6240
tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt 6300
cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac 6360
gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc 6420
ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt 6480
ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc 6540
ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc 6600
agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg 6660
aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag 6720
atccttttaa attaaaaatg aagttttagc acgtgctatt attgaagcat ttatcagggt 6780
tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt 6840
ccgcgcacat ttccccgaaa agtgccacct gtatgcggtg tgaaataccg cacagatgcg 6900
taaggagaaa ataccgcatc aggaaattgt aagcgttaat aattcagaag aactcgtcaa 6960
gaaggcgata gaaggcgatg cgctgcgaat cgggagcggc gataccgtaa agcacgagga 7020
agcggtcagc ccattcgccg ccaagctctt cagcaatatc acgggtagcc aacgctatgt 7080
cctgatagcg gtccgccaca cccagccggc cacagtcgat gaatccagaa aagcggccat 7140
tttccaccat gatattcggc aagcaggcat cgccatgggt cacgacgaga tcctcgccgt 7200
cgggcatgct cgccttgagc ctggcgaaca gttcggctgg cgcgagcccc tgatgctctt 7260
cgtccagatc atcctgatcg acaagaccgg cttccatccg agtacgtgct cgctcgatgc 7320
gatgtttcgc ttggtggtcg aatgggcagg tagccggatc aagcgtatgc agccgccgca 7380
ttgcatcagc catgatggat actttctcgg caggagcaag gtgagatgac aggagatcct 7440
gccccggcac ttcgcccaat agcagccagt cccttcccgc ttcagtgaca acgtcgagca 7500
cagctgcgca aggaacgccc gtcgtggcca gccacgatag ccgcgctgcc tcgtcttgca 7560
gttcattcag ggcaccggac aggtcggtct tgacaaaaag aaccgggcgc ccctgcgctg 7620
acagccggaa cacggcggca tcagagcagc cgattgtctg ttgtgcccag tcatagccga 7680
atagcctctc cacccaagcg gccggagaac ctgcgtgcaa tccatcttgt tcaatcatgc 7740
gaaacgatcc tcatcctgtc tcttgatcag agcttgatcc cctgcgccat cagatccttg 7800
gcggcgagaa agccatccag tttactttgc agggcttccc aaccttacca gagggcgccc 7860
cagctggcaa ttccggttcg cttgctgtcc ataaaaccgc ccagtagaag catatg     7916<210> 14
<211> 7662
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-158

<400> 14
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagagctga ggagggattg agcgatgtct gcattcaata aagaaaattc 3180
aatttcatcc atggcaccac cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa 3240
gaaacacgcg gatgaaatcg ataagtatat acaaggattg gattacaata aaaacaatgt 3300
attagtatac cacggagatg cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg 3360
aaatgaatat attgttgtgg agaaaaagaa gaaatccatc aatcaaaata atgcagacat 3420
tcaagttgtg aatgcaattt cgagcctaac ctatccaggt gctctcgtaa aagcgaattc 3480
ggaattagta gaaaatcaac cagatgttct ccctgtaaaa cgtgattcat taacactcag 3540
cattgatttg ccaggtatga ctaatcaaga caataaaata gttgtaaaaa atgccactaa 3600
atcaaacgtt aacaacgcag taaatacatt agtggaaaga tggaatgaaa aatatgctca 3660
agcttatcca aatgtaagtg caaaaattga ttatgatgac gaaatggctt acagtgaatc 3720
acaattaatt gcgaaatttg gtacagcatt taaagctgta aataatagct tgaatgtaaa 3780
cttcggcgca atcagtgaag ggaaaatgca agaagaagtc attagtttta aacaaattta 3840
ctataacgtg aatgttaatg aacctacaag accttccaga tttttcggca aagctgttac 3900
taaagagcag ttgcaagcgc ttggagtgaa tgcagaaaat cctcctgcat atatctcaag 3960
tgtggcgtat ggccgtcaag tttatttgaa attatcaact aattcccata gtactaaagt 4020
aaaagctgct tttgatgctg ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac 4080
aaatatcatc aaaaattctt ccttcaaagc cgtaatttac ggaggttccg caaaagatga 4140
agttcaaatc atcgacggca acctcggaga cttacgcgat attttgaaaa aaggcgctac 4200
ttttaatcga gaaacaccag gagttcccat tgcttataca acaaacttcc taaaagacaa 4260
tgaattagct gttattaaaa acaactcaga atatattgaa acaacttcaa aagcttatac 4320
agatggaaaa attaacatcg atcactctgg aggatacgtt gctcaattca acatttcttg 4380
ggatgaagta aattatgatc ctgaaggtaa cgaaattgtt caacataaaa actggagcga 4440
aaacaataaa agcaagctag ctcatttcac atcgtccatc tatttgcctg gtaacgcgag 4500
aaatattaat gtttacgcta aagaatgcac tggtttagct tgggaatggt ggagaacggt 4560
aattgatgac cggaacttac cacttgtgaa aaatagaaat atctccatct ggggcaccac 4620
gctttatccg aaatatagta ataaagtaga taatccaatc gaatatgatt ataaagatga 4680
cgatgacaaa taataatcta gaggatccag gaggaacaat atgggcgcag acgacgttgt 4740
tgacagcagc aaatctttcg ttatggaaaa cttcagcagc tatcacggca ccaaaccggg 4800
ctatgtggac tctattcaga aaggcatcca aaaaccgaaa agtggcaccc agggtaacta 4860
tgatgacgat tggaaaggtt tttactccac ggacaataaa tatgatgcgg ccggctactc 4920
ggtcgacaac gaaaatccgc tgagcggtaa agcaggcggt gtggttaaag ttacctatcc 4980
gggcctgacg aaagttctgg cgctgaaagt cgataacgcc gaaaccatca aaaaagaact 5040
gggcctgtca ctgaccgaac cgctgatgga acaagtgggt acggaagaat ttatcaaacg 5100
tttcggcgat ggtgcatccc gcgtcgtgct gtcactgccg tttgctgaag gcagctctag 5160
tgtggaatac attaacaatt gggaacaagc aaaagctctg agcgttgaac tggaaatcaa 5220
tttcgaaacg cgtggtaaac gtggtcaaga tgcgatgtat gaatatatgg ctcaagcgtg 5280
tgcgggtaac cgtgtgcgtt aataaggcgc gccggatccc cgcgccctca tccgaaaggg 5340
cgtatgggta ccgagctcga attcgtaatc atggtcatag ctgtttcctg tgtgaaattg 5400
ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg 5460
tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc 5520
gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt 5580
gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct 5640
gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga 5700
taacgcagga aagaacatgt gagcaaaagg ccagcaaaag cccaggaacc gtaaaaaggc 5760
cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg 5820
ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg 5880
aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt 5940
tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt 6000
gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg 6060
cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact 6120
ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt 6180
cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct 6240
gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac 6300
cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc 6360
tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg 6420
ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta 6480
aaaatgaagt tttagcacgt gctattattg aagcatttat cagggttatt gtctcatgag 6540
cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc 6600
ccgaaaagtg ccacctgtat gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac 6660
cgcatcagga aattgtaagc gttaataatt cagaagaact cgtcaagaag gcgatagaag 6720
gcgatgcgct gcgaatcggg agcggcgata ccgtaaagca cgaggaagcg gtcagcccat 6780
tcgccgccaa gctcttcagc aatatcacgg gtagccaacg ctatgtcctg atagcggtcc 6840
gccacaccca gccggccaca gtcgatgaat ccagaaaagc ggccattttc caccatgata 6900
ttcggcaagc aggcatcgcc atgggtcacg acgagatcct cgccgtcggg catgctcgcc 6960
ttgagcctgg cgaacagttc ggctggcgcg agcccctgat gctcttcgtc cagatcatcc 7020
tgatcgacaa gaccggcttc catccgagta cgtgctcgct cgatgcgatg tttcgcttgg 7080
tggtcgaatg ggcaggtagc cggatcaagc gtatgcagcc gccgcattgc atcagccatg 7140
atggatactt tctcggcagg agcaaggtga gatgacagga gatcctgccc cggcacttcg 7200
cccaatagca gccagtccct tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga 7260
acgcccgtcg tggccagcca cgatagccgc gctgcctcgt cttgcagttc attcagggca 7320
ccggacaggt cggtcttgac aaaaagaacc gggcgcccct gcgctgacag ccggaacacg 7380
gcggcatcag agcagccgat tgtctgttgt gcccagtcat agccgaatag cctctccacc 7440
caagcggccg gagaacctgc gtgcaatcca tcttgttcaa tcatgcgaaa cgatcctcat 7500
cctgtctctt gatcagagct tgatcccctg cgccatcaga tccttggcgg cgagaaagcc 7560
atccagttta ctttgcaggg cttcccaacc ttaccagagg gcgccccagc tggcaattcc 7620
ggttcgcttg ctgtccataa aaccgcccag tagaagcata tg                    7662<210> 15
<211> 7931
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-179

<400> 15
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtct ctctgccgat tgctcaacaa acggaagctg gcgacgcaag cgcattcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaactg gcgcacttca ccagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatatagt aacaaagttg ataacccgat tgaataataa 4740
ggatccagga ggaacaatat gggcgcagac gacgttgttg acagcagcaa atctttcgtt 4800
atggaaaact tcagcagcta tcacggcacc aaaccgggct atgtggactc tattcagaaa 4860
ggcatccaaa aaccgaaaag tggcacccag ggtaactatg atgacgattg gaaaggtttt 4920
tactccacgg acaataaata tgatgcggcc ggctactcgg tcgacaacga aaatccgctg 4980
agcggtaaag caggcggtgt ggttaaagtt acctatccgg gcctgacgaa agttctggcg 5040
ctgaaagtcg ataacgccga aaccatcaaa aaagaactgg gcctgtcact gaccgaaccg 5100
ctgatggaac aagtgggtac ggaagaattt atcaaacgtt tcggcgatgg tgcatcccgc 5160
gtcgtgctgt cactgccgtt tgctgaaggc agctctagtg tggaatacat taacaattgg 5220
gaacaagcaa aagctctgag cgttgaactg gaaatcaatt tcgaaacgcg tggtaaacgt 5280
ggtcaagatg cgatgtatga atatatggct caagcgtgtg cgggtaaccg tgtgcgttaa 5340
taaggcgcgc ctggtagtgt ggggtctccc catgcgagag tagggaactg ccaggcatca 5400
aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt gtttgtcggt 5460
gaacgctctc ctgagtagga caaatccgcc gggagcggat ttgaacgttg cgaagcaacg 5520
gcccggaggg tggcgggcag gacgcccgcc ataaactgcc aggcatcaaa ttaagcagaa 5580
ggccatcctg acggatggcc tttttgcgtt tctacaaact cgagctcgaa ttcgtaatca 5640
tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga 5700
gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt 5760
gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga 5820
atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc 5880
actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg 5940
gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc 6000
cagcaaaagc ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc 6060
ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga 6120
ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc 6180
ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat 6240
agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg 6300
cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc 6360
aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga 6420
gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact 6480
agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt 6540
ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag 6600
cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg 6660
tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa 6720
aggatcttca cctagatcct tttaaattaa aaatgaagtt ttagcacgtg ctattattga 6780
agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat 6840
aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgtatg cggtgtgaaa 6900
taccgcacag atgcgtaagg agaaaatacc gcatcaggaa attgtaagcg ttaataattc 6960
agaagaactc gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga gcggcgatac 7020
cgtaaagcac gaggaagcgg tcagcccatt cgccgccaag ctcttcagca atatcacggg 7080
tagccaacgc tatgtcctga tagcggtccg ccacacccag ccggccacag tcgatgaatc 7140
cagaaaagcg gccattttcc accatgatat tcggcaagca ggcatcgcca tgggtcacga 7200
cgagatcctc gccgtcgggc atgctcgcct tgagcctggc gaacagttcg gctggcgcga 7260
gcccctgatg ctcttcgtcc agatcatcct gatcgacaag accggcttcc atccgagtac 7320
gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg 7380
tatgcagccg ccgcattgca tcagccatga tggatacttt ctcggcagga gcaaggtgag 7440
atgacaggag atcctgcccc ggcacttcgc ccaatagcag ccagtccctt cccgcttcag 7500
tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg 7560
ctgcctcgtc ttgcagttca ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg 7620
ggcgcccctg cgctgacagc cggaacacgg cggcatcaga gcagccgatt gtctgttgtg 7680
cccagtcata gccgaatagc ctctccaccc aagcggccgg agaacctgcg tgcaatccat 7740
cttgttcaat catgcgaaac gatcctcatc ctgtctcttg atcagagctt gatcccctgc 7800
gccatcagat ccttggcggc gagaaagcca tccagtttac tttgcagggc ttcccaacct 7860
taccagaggg cgccccagct ggcaattccg gttcgcttgc tgtccataaa accgcccagt 7920
agaagcatat g                                                      7931<210> 16
<211> 7931
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-191

<400> 16
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtgt ccctgccgat tgcacaacaa accgaagcgg gcgatgcgag cgccttcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaaacc gcgcacttca cgagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatactcc aacaaagttg ataacccgat tgaataataa 4740
ggatccagga ggaacaatat gggcgcagac gacgttgttg acagcagcaa atctttcgtt 4800
atggaaaact tcagcagcta tcacggcacc aaaccgggct atgtggactc tattcagaaa 4860
ggcatccaaa aaccgaaaag tggcacccag ggtaactatg atgacgattg gaaaggtttt 4920
tactccacgg acaataaata tgatgcggcc ggctactcgg tcgacaacga aaatccgctg 4980
agcggtaaag caggcggtgt ggttaaagtt acctatccgg gcctgacgaa agttctggcg 5040
ctgaaagtcg ataacgccga aaccatcaaa aaagaactgg gcctgtcact gaccgaaccg 5100
ctgatggaac aagtgggtac ggaagaattt atcaaacgtt tcggcgatgg tgcatcccgc 5160
gtcgtgctgt cactgccgtt tgctgaaggc agctctagtg tggaatacat taacaattgg 5220
gaacaagcaa aagctctgag cgttgaactg gaaatcaatt tcgaaacgcg tggtaaacgt 5280
ggtcaagatg cgatgtatga atatatggct caagcgtgtg cgggtaaccg tgtgcgttaa 5340
taaggcgcgc ctggtagtgt ggggtctccc catgcgagag tagggaactg ccaggcatca 5400
aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt gtttgtcggt 5460
gaacgctctc ctgagtagga caaatccgcc gggagcggat ttgaacgttg cgaagcaacg 5520
gcccggaggg tggcgggcag gacgcccgcc ataaactgcc aggcatcaaa ttaagcagaa 5580
ggccatcctg acggatggcc tttttgcgtt tctacaaact cgagctcgaa ttcgtaatca 5640
tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga 5700
gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt 5760
gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga 5820
atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc 5880
actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg 5940
gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc 6000
cagcaaaagc ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc 6060
ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga 6120
ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc 6180
ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat 6240
agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg 6300
cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc 6360
aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga 6420
gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact 6480
agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt 6540
ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag 6600
cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg 6660
tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa 6720
aggatcttca cctagatcct tttaaattaa aaatgaagtt ttagcacgtg ctattattga 6780
agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat 6840
aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgtatg cggtgtgaaa 6900
taccgcacag atgcgtaagg agaaaatacc gcatcaggaa attgtaagcg ttaataattc 6960
agaagaactc gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga gcggcgatac 7020
cgtaaagcac gaggaagcgg tcagcccatt cgccgccaag ctcttcagca atatcacggg 7080
tagccaacgc tatgtcctga tagcggtccg ccacacccag ccggccacag tcgatgaatc 7140
cagaaaagcg gccattttcc accatgatat tcggcaagca ggcatcgcca tgggtcacga 7200
cgagatcctc gccgtcgggc atgctcgcct tgagcctggc gaacagttcg gctggcgcga 7260
gcccctgatg ctcttcgtcc agatcatcct gatcgacaag accggcttcc atccgagtac 7320
gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg 7380
tatgcagccg ccgcattgca tcagccatga tggatacttt ctcggcagga gcaaggtgag 7440
atgacaggag atcctgcccc ggcacttcgc ccaatagcag ccagtccctt cccgcttcag 7500
tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg 7560
ctgcctcgtc ttgcagttca ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg 7620
ggcgcccctg cgctgacagc cggaacacgg cggcatcaga gcagccgatt gtctgttgtg 7680
cccagtcata gccgaatagc ctctccaccc aagcggccgg agaacctgcg tgcaatccat 7740
cttgttcaat catgcgaaac gatcctcatc ctgtctcttg atcagagctt gatcccctgc 7800
gccatcagat ccttggcggc gagaaagcca tccagtttac tttgcagggc ttcccaacct 7860
taccagaggg cgccccagct ggcaattccg gttcgcttgc tgtccataaa accgcccagt 7920
agaagcatat g                                                      7931<210> 17
<211> 7844
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-183

<400> 17
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg atccgcttca aaaagaccaa actgattgcg 3180
agcattgcga tggcactgtg tctgttctcc cagccggtga tttcgttctc aaaagatatt 3240
accgacaaaa atcagtccat cgattcaggc attagctctc tgtcttataa ccgtaatgaa 3300
gtgctggcgt ccaatggtga caaaatcgaa tcatttgttc cgaaagaagg caaaaaagcc 3360
ggtaacaaat tcattgtggt tgaacgtcag aaacgctctc tgaccacgag tccggttgat 3420
atctccatta tcgattcagt caatgaccgt acctatccgg gtgcactgca actggcagac 3480
aaagcatttg tggaaaaccg tccgacgatt ctgatggtta aacgcaaacc gattaacatc 3540
aatattgatc tgccgggcct gaaaggtgaa aatagtatca aagtggatga cccgacctat 3600
ggcaaagttt cgggtgcaat tgatgaactg gtcagcaaat ggaacgaaaa atacagttcc 3660
acccatacgc tgccggcgcg tacccagtat tcggaaagca tggtgtactc taaaagtcaa 3720
atctcatcgg cgctgaacgt taatgccaaa gtcctggaaa actctctggg tgtggatttt 3780
aatgcggttg ccaacaatga gaaaaaagtg atgatcctgg catataaaca gattttctac 3840
accgttagtg ctgatctgcc gaaaaacccg tctgacctgt ttgatgacag tgtcacgttc 3900
aacgatctga aacaaaaagg cgtgtctaat gaagcgccgc cgctgatggt gtctaacgtt 3960
gcctatggtc gtaccattta cgttaaactg gaaaccacga gctctagtaa agatgtccag 4020
gcggccttta aagccctgat caaaaacacc gatatcaaaa atagccagca atacaaagac 4080
atctacgaaa attcctcatt caccgcagtc gtgctgggcg gtgatgctca ggaacacaac 4140
aaagttgtca cgaaagattt tgacgaaatc cgcaaagtga ttaaagataa cgcaaccttc 4200
tcgacgaaaa atccggctta tccgatttcg tacaccagcg tttttctgaa agataacagc 4260
gtcgcagctg tgcataataa aaccgactat atcgaaacca ccagcaccga atacagcaaa 4320
ggcaaaatta atctggatca ctccggtgca tatgtcgctc agttcgaagt ggcctgggat 4380
gaagtttcat acgacaaaga aggcaatgaa gtgctgaccc ataaaacgtg ggatggtaac 4440
tatcaagaca aaaccgcaca ctactccacg gttattccgc tggaagcaaa cgctcgtaat 4500
atccgcatta aagcgcgtga atgcaccggt ctggcatggg aatggtggcg tgatgtcatc 4560
agcgaatatg acgtgccgct gacgaacaat atcaatgtgt caatctgggg caccacgctg 4620
tatccgggta gttccatcac ctataattaa taaggatcca ggaggaacaa tatgggcgca 4680
gacgacgttg ttgacagcag caaatctttc gttatggaaa acttcagcag ctatcacggc 4740
accaaaccgg gctatgtgga ctctattcag aaaggcatcc aaaaaccgaa aagtggcacc 4800
cagggtaact atgatgacga ttggaaaggt ttttactcca cggacaataa atatgatgcg 4860
gccggctact cggtcgacaa cgaaaatccg ctgagcggta aagcaggcgg tgtggttaaa 4920
gttacctatc cgggcctgac gaaagttctg gcgctgaaag tcgataacgc cgaaaccatc 4980
aaaaaagaac tgggcctgtc actgaccgaa ccgctgatgg aacaagtggg tacggaagaa 5040
tttatcaaac gtttcggcga tggtgcatcc cgcgtcgtgc tgtcactgcc gtttgctgaa 5100
ggcagctcta gtgtggaata cattaacaat tgggaacaag caaaagctct gagcgttgaa 5160
ctggaaatca atttcgaaac gcgtggtaaa cgtggtcaag atgcgatgta tgaatatatg 5220
gctcaagcgt gtgcgggtaa ccgtgtgcgt taataaggcg cgcctggtag tgtggggtct 5280
ccccatgcga gagtagggaa ctgccaggca tcaaataaaa cgaaaggctc agtcgaaaga 5340
ctgggccttt cgttttatct gttgtttgtc ggtgaacgct ctcctgagta ggacaaatcc 5400
gccgggagcg gatttgaacg ttgcgaagca acggcccgga gggtggcggg caggacgccc 5460
gccataaact gccaggcatc aaattaagca gaaggccatc ctgacggatg gcctttttgc 5520
gtttctacaa actcgagctc gaattcgtaa tcatggtcat agctgtttcc tgtgtgaaat 5580
tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg 5640
ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag 5700
tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt 5760
ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg 5820
ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg 5880
gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa agcccaggaa ccgtaaaaag 5940
gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga 6000
cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct 6060
ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc 6120
tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg 6180
gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc 6240
tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca 6300
ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag 6360
ttcttgaagt ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct 6420
ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc 6480
accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga 6540
tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca 6600
cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat 6660
taaaaatgaa gttttagcac gtgctattat tgaagcattt atcagggtta ttgtctcatg 6720
agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt 6780
ccccgaaaag tgccacctgt atgcggtgtg aaataccgca cagatgcgta aggagaaaat 6840
accgcatcag gaaattgtaa gcgttaataa ttcagaagaa ctcgtcaaga aggcgataga 6900
aggcgatgcg ctgcgaatcg ggagcggcga taccgtaaag cacgaggaag cggtcagccc 6960
attcgccgcc aagctcttca gcaatatcac gggtagccaa cgctatgtcc tgatagcggt 7020
ccgccacacc cagccggcca cagtcgatga atccagaaaa gcggccattt tccaccatga 7080
tattcggcaa gcaggcatcg ccatgggtca cgacgagatc ctcgccgtcg ggcatgctcg 7140
ccttgagcct ggcgaacagt tcggctggcg cgagcccctg atgctcttcg tccagatcat 7200
cctgatcgac aagaccggct tccatccgag tacgtgctcg ctcgatgcga tgtttcgctt 7260
ggtggtcgaa tgggcaggta gccggatcaa gcgtatgcag ccgccgcatt gcatcagcca 7320
tgatggatac tttctcggca ggagcaaggt gagatgacag gagatcctgc cccggcactt 7380
cgcccaatag cagccagtcc cttcccgctt cagtgacaac gtcgagcaca gctgcgcaag 7440
gaacgcccgt cgtggccagc cacgatagcc gcgctgcctc gtcttgcagt tcattcaggg 7500
caccggacag gtcggtcttg acaaaaagaa ccgggcgccc ctgcgctgac agccggaaca 7560
cggcggcatc agagcagccg attgtctgtt gtgcccagtc atagccgaat agcctctcca 7620
cccaagcggc cggagaacct gcgtgcaatc catcttgttc aatcatgcga aacgatcctc 7680
atcctgtctc ttgatcagag cttgatcccc tgcgccatca gatccttggc ggcgagaaag 7740
ccatccagtt tactttgcag ggcttcccaa ccttaccaga gggcgcccca gctggcaatt 7800
ccggttcgct tgctgtccat aaaaccgccc agtagaagca tatg                  7844<210> 18
<211> 8084
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-196

<400> 18
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagagctga ggagggattg agcgatgtct gcattcaata aagaaaattc 3180
aatttcatcc atggcaccac cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa 3240
gaaacacgcg gatgaaatcg ataagtatat acaaggattg gattacaata aaaacaatgt 3300
attagtatac cacggagatg cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg 3360
aaatgaatat attgttgtgg agaaaaagaa gaaatccatc aatcaaaata atgcagacat 3420
tcaagttgtg aatgcaattt cgagcctaac ctatccaggt gctctcgtaa aagcgaattc 3480
ggaattagta gaaaatcaac cagatgttct ccctgtaaaa cgtgattcat taacactcag 3540
cattgatttg ccaggtatga ctaatcaaga caataaaata gttgtaaaaa atgccactaa 3600
atcaaacgtt aacaacgcag taaatacatt agtggaaaga tggaatgaaa aatatgctca 3660
agcttatcca aatgtaagtg caaaaattga ttatgatgac gaaatggctt acagtgaatc 3720
acaattaatt gcgaaatttg gtacagcatt taaagctgta aataatagct tgaatgtaaa 3780
cttcggcgca atcagtgaag ggaaaatgca agaagaagtc attagtttta aacaaattta 3840
ctataacgtg aatgttaatg aacctacaag accttccaga tttttcggca aagctgttac 3900
taaagagcag ttgcaagcgc ttggagtgaa tgcagaaaat cctcctgcat atatctcaag 3960
tgtggcgtat ggccgtcaag tttatttgaa attatcaact aattcccata gtactaaagt 4020
aaaagctgct tttgatgctg ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac 4080
aaatatcatc aaaaattctt ccttcaaagc cgtaatttac ggaggttccg caaaagatga 4140
agttcaaatc atcgacggca acctcggaga cttacgcgat attttgaaaa aaggcgctac 4200
ttttaatcga gaaacaccag gagttcccat tgcttataca acaaacttcc taaaagacaa 4260
tgaattagct gttattaaaa acaactcaga atatattgaa acaacttcaa aagcttatac 4320
agatggaaaa attaacatcg atcactctgg aggatacgtt gctcaattca acatttcttg 4380
ggatgaagta aattatgatc ctgaaggtaa cgaaattgtt caacataaaa actggagcga 4440
aaacaataaa agcaagctag ctcatttcac atcgtccatc tatttgcctg gtaacgcgag 4500
aaatattaat gtttacgcta aagaatgcac tggtttagct tgggaatggt ggagaacggt 4560
aattgatgac cggaacttac cacttgtgaa aaatagaaat atctccatct ggggcaccac 4620
gctttatccg aaatatagta ataaagtaga taatccaatc gaatatgatt ataaagatga 4680
cgatgacaaa taataatcta gaggatccag gaggattact atatgggtct ggataccgtg 4740
agcttctcga cgaaaggcgc aacctacatt acctacgtga acttcctgaa cgaactgcgt 4800
gtgaaactga aaccggaagg caacagccat ggtatcccgc tgctgcgtaa aaaatgcgat 4860
gacccgggca aatgttttgt tctggtcgca ctgagtaacg ataatggtca gctggcagaa 4920
attgctatcg acgtgacctc agtttatgtg gttggctacc aagtccgtaa ccgctcgtat 4980
ttctttaaag atgcaccgga cgcggcctac gaaggtctgt ttaaaaatac catcaaaacg 5040
cgcctgcact tcggcggtag ttatccgtcc ctggaaggcg aaaaagcgta tcgtgaaacc 5100
acggatctgg gcattgaacc gctgcgcatt ggtatcaaaa aactggatga aaacgcgatt 5160
gacaattata aaccgacgga aatcgccagc tctctgctgg tcgtgattca gatggtgtca 5220
gaagccgctc gttttacctt tatcgaaaat caaatccgca acaactttca acaaagaatt 5280
cgcccggcta ataatacgat ctcgctggaa aataaatggg gtaaactgag ctttcaaatc 5340
cgcacctcgg gcgctaacgg catgttctcc gaagcggtgg aactggaacg tgccaacggc 5400
aaaaaatatt acgttaccgc tgtggaccag gtgaaaccga aaatcgctct gctgaaattc 5460
gttgataaag acccgaaata ataaggatcc cctaggggcg cgcctggtag tgtggggtct 5520
ccccatgcga gagtagggaa ctgccaggca tcaaataaaa cgaaaggctc agtcgaaaga 5580
ctgggccttt cgttttatct gttgtttgtc ggtgaacgct ctcctgagta ggacaaatcc 5640
gccgggagcg gatttgaacg ttgcgaagca acggcccgga gggtggcggg caggacgccc 5700
gccataaact gccaggcatc aaattaagca gaaggccatc ctgacggatg gcctttttgc 5760
gtttctacaa actcgagctc gaattcgtaa tcatggtcat agctgtttcc tgtgtgaaat 5820
tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg 5880
ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag 5940
tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt 6000
ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg 6060
ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg 6120
gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa agcccaggaa ccgtaaaaag 6180
gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga 6240
cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct 6300
ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc 6360
tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg 6420
gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc 6480
tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca 6540
ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag 6600
ttcttgaagt ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct 6660
ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc 6720
accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga 6780
tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca 6840
cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat 6900
taaaaatgaa gttttagcac gtgctattat tgaagcattt atcagggtta ttgtctcatg 6960
agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt 7020
ccccgaaaag tgccacctgt atgcggtgtg aaataccgca cagatgcgta aggagaaaat 7080
accgcatcag gaaattgtaa gcgttaataa ttcagaagaa ctcgtcaaga aggcgataga 7140
aggcgatgcg ctgcgaatcg ggagcggcga taccgtaaag cacgaggaag cggtcagccc 7200
attcgccgcc aagctcttca gcaatatcac gggtagccaa cgctatgtcc tgatagcggt 7260
ccgccacacc cagccggcca cagtcgatga atccagaaaa gcggccattt tccaccatga 7320
tattcggcaa gcaggcatcg ccatgggtca cgacgagatc ctcgccgtcg ggcatgctcg 7380
ccttgagcct ggcgaacagt tcggctggcg cgagcccctg atgctcttcg tccagatcat 7440
cctgatcgac aagaccggct tccatccgag tacgtgctcg ctcgatgcga tgtttcgctt 7500
ggtggtcgaa tgggcaggta gccggatcaa gcgtatgcag ccgccgcatt gcatcagcca 7560
tgatggatac tttctcggca ggagcaaggt gagatgacag gagatcctgc cccggcactt 7620
cgcccaatag cagccagtcc cttcccgctt cagtgacaac gtcgagcaca gctgcgcaag 7680
gaacgcccgt cgtggccagc cacgatagcc gcgctgcctc gtcttgcagt tcattcaggg 7740
caccggacag gtcggtcttg acaaaaagaa ccgggcgccc ctgcgctgac agccggaaca 7800
cggcggcatc agagcagccg attgtctgtt gtgcccagtc atagccgaat agcctctcca 7860
cccaagcggc cggagaacct gcgtgcaatc catcttgttc aatcatgcga aacgatcctc 7920
atcctgtctc ttgatcagag cttgatcccc tgcgccatca gatccttggc ggcgagaaag 7980
ccatccagtt tactttgcag ggcttcccaa ccttaccaga gggcgcccca gctggcaatt 8040
ccggttcgct tgctgtccat aaaaccgccc agtagaagca tatg                  8084<210> 19
<211> 8122
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-181

<400> 19
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtct ctctgccgat tgctcaacaa acggaagctg gcgacgcaag cgcattcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaactg gcgcacttca ccagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatatagt aacaaagttg ataacccgat tgaataataa 4740
ggatccagga ggattactat atgggtctgg ataccgtgag cttctcgacg aaaggcgcaa 4800
cctacattac ctacgtgaac ttcctgaacg aactgcgtgt gaaactgaaa ccggaaggca 4860
acagccatgg tatcccgctg ctgcgtaaaa aatgcgatga cccgggcaaa tgttttgttc 4920
tggtcgcact gagtaacgat aatggtcagc tggcagaaat tgctatcgac gtgacctcag 4980
tttatgtggt tggctaccaa gtccgtaacc gctcgtattt ctttaaagat gcaccggacg 5040
cggcctacga aggtctgttt aaaaatacca tcaaaacgcg cctgcacttc ggcggtagtt 5100
atccgtccct ggaaggcgaa aaagcgtatc gtgaaaccac ggatctgggc attgaaccgc 5160
tgcgcattgg tatcaaaaaa ctggatgaaa acgcgattga caattataaa ccgacggaaa 5220
tcgccagctc tctgctggtc gtgattcaga tggtgtcaga agccgctcgt tttaccttta 5280
tcgaaaatca aatccgcaac aactttcaac aaagaattcg cccggctaat aatacgatct 5340
cgctggaaaa taaatggggt aaactgagct ttcaaatccg cacctcgggc gctaacggca 5400
tgttctccga agcggtggaa ctggaacgtg ccaacggcaa aaaatattac gttaccgctg 5460
tggaccaggt gaaaccgaaa atcgctctgc tgaaattcgt tgataaagac ccgaaataat 5520
aaggatcccc taggggcgcg cctggtagtg tggggtctcc ccatgcgaga gtagggaact 5580
gccaggcatc aaataaaacg aaaggctcag tcgaaagact gggcctttcg ttttatctgt 5640
tgtttgtcgg tgaacgctct cctgagtagg acaaatccgc cgggagcgga tttgaacgtt 5700
gcgaagcaac ggcccggagg gtggcgggca ggacgcccgc cataaactgc caggcatcaa 5760
attaagcaga aggccatcct gacggatggc ctttttgcgt ttctacaaac tcgagctcga 5820
attcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac 5880
acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac 5940
tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc 6000
tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg 6060
cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc 6120
actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt 6180
gagcaaaagg ccagcaaaag cccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc 6240
ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa 6300
acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc 6360
ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg 6420
cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc 6480
tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc 6540
gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca 6600
ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact 6660
acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg 6720
gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt 6780
ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct 6840
tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga 6900
gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttagcacgt 6960
gctattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta 7020
tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgtat 7080
gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcagga aattgtaagc 7140
gttaataatt cagaagaact cgtcaagaag gcgatagaag gcgatgcgct gcgaatcggg 7200
agcggcgata ccgtaaagca cgaggaagcg gtcagcccat tcgccgccaa gctcttcagc 7260
aatatcacgg gtagccaacg ctatgtcctg atagcggtcc gccacaccca gccggccaca 7320
gtcgatgaat ccagaaaagc ggccattttc caccatgata ttcggcaagc aggcatcgcc 7380
atgggtcacg acgagatcct cgccgtcggg catgctcgcc ttgagcctgg cgaacagttc 7440
ggctggcgcg agcccctgat gctcttcgtc cagatcatcc tgatcgacaa gaccggcttc 7500
catccgagta cgtgctcgct cgatgcgatg tttcgcttgg tggtcgaatg ggcaggtagc 7560
cggatcaagc gtatgcagcc gccgcattgc atcagccatg atggatactt tctcggcagg 7620
agcaaggtga gatgacagga gatcctgccc cggcacttcg cccaatagca gccagtccct 7680
tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga acgcccgtcg tggccagcca 7740
cgatagccgc gctgcctcgt cttgcagttc attcagggca ccggacaggt cggtcttgac 7800
aaaaagaacc gggcgcccct gcgctgacag ccggaacacg gcggcatcag agcagccgat 7860
tgtctgttgt gcccagtcat agccgaatag cctctccacc caagcggccg gagaacctgc 7920
gtgcaatcca tcttgttcaa tcatgcgaaa cgatcctcat cctgtctctt gatcagagct 7980
tgatcccctg cgccatcaga tccttggcgg cgagaaagcc atccagttta ctttgcaggg 8040
cttcccaacc ttaccagagg gcgccccagc tggcaattcc ggttcgcttg ctgtccataa 8100
aaccgcccag tagaagcata tg                                          8122<210> 20
<211> 8122
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-193

<400> 20
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg aaaaagatta tgctggtctt tattaccctg 3180
attctggtgt ccctgccgat tgcacaacaa accgaagcgg gcgatgcgag cgccttcaac 3240
aaagaaaaca gcatcagctc tatggcaccg ccggcttcac cgccggcatc gccgaaaacc 3300
ccgatcgaga aaaaacatgc tgatgaaatc gacaaataca tccagggcct ggactacaat 3360
aaaaacaatg tgctggttta tcacggtgat gccgttacga atgtcccgcc gcgtaaaggc 3420
tataaagacg gtaacgaata catcgtggtt gaaaagaaaa agaaaagcat caaccagaac 3480
aatgctgata ttcaagtcgt gaacgcgatc agttccctga cctatccggg cgcactggtc 3540
aaagctaata gcgaactggt ggaaaaccag ccggatgtgc tgccggttaa acgtgacagc 3600
ctgaccctgt ctattgatct gccgggtatg acgaaccaag ataacaaaat cgttgtcaaa 3660
aacgcaacca aaagtaacgt caacaatgct gtgaatacgc tggttgaacg ctggaacgaa 3720
aaatatgcgc aggcctaccc gaatgtgtcc gccaaaattg attatgatga cgaaatggcg 3780
tactcagaat cgcaactgat cgccaaattt ggcaccgcgt tcaaagccgt taacaatagc 3840
ctgaacgtca attttggcgc gatttctgaa ggtaaaatgc aggaaatggt gatctcattc 3900
aaacaaatct actacaacgt caacgtgaac gaaccgaccc gtccgtcgcg ctttttcggc 3960
aaagccgtca cgaaagaaca gctgcaagcg ctgggtgtga atgccgaaaa cccgccggca 4020
tatatttcat cggtggcgta tggtcgccag gtttacctga aactgagcac caacagccat 4080
tctacgaaag ttaaagcggc ctttaaagca gctgtctctg gcaaaagtgt ctccggtgat 4140
gtggaactga ccaacatcat caaaaacagc tctttcaaag ccgttattta tggcggttct 4200
gcaaaagatg aagtccagat tatcgacggc aatctgggtg atctgcgtga cattctgaaa 4260
aaaggcgcga cctttaaccg cgaaacgccg ggtgtgccga tcgcctacac cacgaatttc 4320
ctgaaagata acgaactggc agttatcaaa aacaactcag aatacatcga aaccacgtcg 4380
aaagcttaca ccgatggcaa aattaatatc gaccacagtg gcggttatgt tgcacagttt 4440
aacatttcct gggatgaagt gaattacgac ccggagggta acgaaatcgt tcaacataaa 4500
aactggagtg aaaacaacaa atccaaaacc gcgcacttca cgagttccat ttatctgccg 4560
ggcaacgctc gtaatatcaa cgtgtacgcg aaagaatgca ccggtctggc ctgggaatgg 4620
tggcgtacgg tgattgatga ccgcaacctg ccgctggtta aaaatcgcaa catctccatc 4680
tggggcacca ccctgtaccc gaaatactcc aacaaagttg ataacccgat tgaataataa 4740
ggatccagga ggattactat atgggtctgg ataccgtgag cttctcgacg aaaggcgcaa 4800
cctacattac ctacgtgaac ttcctgaacg aactgcgtgt gaaactgaaa ccggaaggca 4860
acagccatgg tatcccgctg ctgcgtaaaa aatgcgatga cccgggcaaa tgttttgttc 4920
tggtcgcact gagtaacgat aatggtcagc tggcagaaat tgctatcgac gtgacctcag 4980
tttatgtggt tggctaccaa gtccgtaacc gctcgtattt ctttaaagat gcaccggacg 5040
cggcctacga aggtctgttt aaaaatacca tcaaaacgcg cctgcacttc ggcggtagtt 5100
atccgtccct ggaaggcgaa aaagcgtatc gtgaaaccac ggatctgggc attgaaccgc 5160
tgcgcattgg tatcaaaaaa ctggatgaaa acgcgattga caattataaa ccgacggaaa 5220
tcgccagctc tctgctggtc gtgattcaga tggtgtcaga agccgctcgt tttaccttta 5280
tcgaaaatca aatccgcaac aactttcaac aaagaattcg cccggctaat aatacgatct 5340
cgctggaaaa taaatggggt aaactgagct ttcaaatccg cacctcgggc gctaacggca 5400
tgttctccga agcggtggaa ctggaacgtg ccaacggcaa aaaatattac gttaccgctg 5460
tggaccaggt gaaaccgaaa atcgctctgc tgaaattcgt tgataaagac ccgaaataat 5520
aaggatcccc taggggcgcg cctggtagtg tggggtctcc ccatgcgaga gtagggaact 5580
gccaggcatc aaataaaacg aaaggctcag tcgaaagact gggcctttcg ttttatctgt 5640
tgtttgtcgg tgaacgctct cctgagtagg acaaatccgc cgggagcgga tttgaacgtt 5700
gcgaagcaac ggcccggagg gtggcgggca ggacgcccgc cataaactgc caggcatcaa 5760
attaagcaga aggccatcct gacggatggc ctttttgcgt ttctacaaac tcgagctcga 5820
attcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac 5880
acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac 5940
tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc 6000
tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg 6060
cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc 6120
actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt 6180
gagcaaaagg ccagcaaaag cccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc 6240
ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa 6300
acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc 6360
ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg 6420
cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc 6480
tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc 6540
gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca 6600
ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact 6660
acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg 6720
gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt 6780
ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct 6840
tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga 6900
gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttagcacgt 6960
gctattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta 7020
tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgtat 7080
gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcagga aattgtaagc 7140
gttaataatt cagaagaact cgtcaagaag gcgatagaag gcgatgcgct gcgaatcggg 7200
agcggcgata ccgtaaagca cgaggaagcg gtcagcccat tcgccgccaa gctcttcagc 7260
aatatcacgg gtagccaacg ctatgtcctg atagcggtcc gccacaccca gccggccaca 7320
gtcgatgaat ccagaaaagc ggccattttc caccatgata ttcggcaagc aggcatcgcc 7380
atgggtcacg acgagatcct cgccgtcggg catgctcgcc ttgagcctgg cgaacagttc 7440
ggctggcgcg agcccctgat gctcttcgtc cagatcatcc tgatcgacaa gaccggcttc 7500
catccgagta cgtgctcgct cgatgcgatg tttcgcttgg tggtcgaatg ggcaggtagc 7560
cggatcaagc gtatgcagcc gccgcattgc atcagccatg atggatactt tctcggcagg 7620
agcaaggtga gatgacagga gatcctgccc cggcacttcg cccaatagca gccagtccct 7680
tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga acgcccgtcg tggccagcca 7740
cgatagccgc gctgcctcgt cttgcagttc attcagggca ccggacaggt cggtcttgac 7800
aaaaagaacc gggcgcccct gcgctgacag ccggaacacg gcggcatcag agcagccgat 7860
tgtctgttgt gcccagtcat agccgaatag cctctccacc caagcggccg gagaacctgc 7920
gtgcaatcca tcttgttcaa tcatgcgaaa cgatcctcat cctgtctctt gatcagagct 7980
tgatcccctg cgccatcaga tccttggcgg cgagaaagcc atccagttta ctttgcaggg 8040
cttcccaacc ttaccagagg gcgccccagc tggcaattcc ggttcgcttg ctgtccataa 8100
aaccgcccag tagaagcata tg                                          8122<210> 21
<211> 8035
<212> DNA
<213> Artificial Sequence

<220> 
<223> pVX-185

<400> 21
aagcttaatt aatctttctg cgaattgaga tgacgccact ggctgggcgt catcccggtt 60
tcccgggtaa acaccaccga aaaatagtta ctatcttcaa agccacattc ggtcgaaata 120
tcactgatta acaggcggct atgctggaga agatattgcg catgacacac tctgacctgt 180
cgcagatatt gattgatggt cattccagtc tgctggcgaa attgctgacg caaaacgcgc 240
tcactgcacg atgcctcatc acaaaattta tccagcgcaa agggactttt caggctagcc 300
gccagccggg taatcagctt atccagcaac gtttcgctgg atgttggcgg caacgaatca 360
ctggtgtaac gatggcgatt cagcaacatc accaactgcc cgaacagcaa ctcagccatt 420
tcgttagcaa acggcacatg ctgactactt tcatgctcaa gctgaccgat aacctgccgc 480
gcctgcgcca tccccatgct acctaagcgc cagtgtggtt gccctgcgct ggcgttaaat 540
cccggaatcg ccccctgcca gtcaagattc agcttcagac gctccgggca ataaataata 600
ttctgcaaaa ccagatcgtt aacggaagcg taggagtgtt tatcgtcagc atgaatgtaa 660
aagagatcgc cacgggtaat gcgataaggg cgatcgttga gtacatgcag gccattaccg 720
cgccagacaa tcaccagctc acaaaaatca tgtgtatgtt cagcaaagac atcttgcgga 780
taacggtcag ccacagcgac tgcctgctgg tcgctggcaa aaaaatcatc tttgagaagt 840
tttaactgat gcgccaccgt ggctacctcg gccagagaac gaagttgatt attcgcaata 900
tggcgtacaa atacgttgag aagattcgcg ttattgcaga aagccatccc gtccctggcg 960
aatatcacgc ggtgaccagt taaactctcg gcgaaaaagc gtcgaaaagt ggttactgtc 1020
gctgaatcca cagcgatagg cgatgtcagt aacgctggcc tcgctgtggc gtagcagatg 1080
tcgggctttc atcagtcgca ggcggttcag gtatcgctga ggcgtcagtc ccgtttgctg 1140
cttaagctgc cgatgtagcg tacgcagtga aagagaaaat tgatccgcca cggcatccca 1200
attcacctca tcggcaaaat ggtcctccag ccaggccaga agcaagttga gacgtgatgc 1260
gctgttttcc aggttctcct gcaaactgct tttacgcagc aagagcagta attgcataaa 1320
caagatctcg cgactggcgg tcgagggtaa atcattttcc ccttcctgct gttccatctg 1380
tgcaaccagc tgtcgcacct gctgcaatac gctgtggtta acgcgccagt gagacggata 1440
ctgcccatcc agctcttgtg gcagcaactg attcagcccg gcgagaaact gaaatcgatc 1500
cggcgagcga tacagcacat tggtcagaca cagattatcg gtatgttcat acagatgccg 1560
atcatgatcg cgtacgaaac agaccgtgcc accggtgatg gtatagggct gcccattaaa 1620
cacatgaata cccgtgccat gttcgacaat cacaatttca tgaaaatcat gatgatgttc 1680
aggaaaatcc gcctgcggga gccggggttc tatcgccacg gacgcgttac cagacggaaa 1740
aaaatccaca ctatgtaata cggtcatact ggcctcctga tgtcgtcaac acggcgaaat 1800
agtaatcacg aggtcaggtt cttaccttaa attttcgacg gaaaaccacg taaaaaacgt 1860
cgatttttca agatacagcg tgaattttca ggaaatgcgg tgagcatcac atcaccacaa 1920
ttcagcaaat tgtgaacatc atcacgttca tctttccctg gttgccaatg gcccattttc 1980
ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta gactggtcgt aatgaaattc 2040
aggaggatgg tcgacatgaa agccacgaaa ctggttctgg gtgctgttat cctgggttcc 2100
acgctgctgg cgggttgttc ctctaatgcg aaaatcgatc aaggcatcaa cccgtatgtg 2160
ggctttgaaa tgggttacga ttggctgggt cgtatgccgt ataaaggcag cgttgaaaat 2220
ggtgcataca aagctcaggg cgtccaactg accgcgaaac tgggttatcc gatcacggat 2280
gacctggata tttacacccg tctgggcggt atggtctggc gtgcagatac gaaaagcaac 2340
gtgtatggca aaaatcatga caccggtgtg tctccggttt tcgcgggcgg tgttgaatat 2400
gccatcacgc cggaaattgc aacccgtctg gaataccagt ggaccaacaa tatcggcgat 2460
gcacacacga ttggtacccg cccggataac ggcattccgg gtatcgacga aattctggcg 2520
gccctgccga aaacggatac ctataaactg attctgaatg gcaaaacgct gaaaggtgaa 2580
accacgaccg aagctgttga cgcagctacc gcggaaaaag tcttcaaaca atacgctaac 2640
gataatggcg tggacggtga atggacctac gatgacgcga cgaaaacctt cacggtcacc 2700
gaaaaaccgg aagtgatcga tgccagtgaa ctgacgccgg cagttacgac ctataaactg 2760
gtcattaacg gcaaaaccct gaaaggtgaa acgaccacgg aagctgtgga tgcagcaacc 2820
gcagaaaaag ttttcaaaca gtacgccaat gacaacggtg tggacggcga atggacgtac 2880
gatgacgcaa cgaaaacctt cacggtgacc gaaaaaccgg aagttatcga tgcctccgaa 2940
ctgaccccgg cagtcaccac gtataaactg gtgatcaatg gtaaaacgct gaaaggcgaa 3000
accacgacca aagcggttga tgccgaaacc gcagaaaaag cttttaaaca atacgcgaat 3060
gacaatggcg tggatggcgt gtggacctac gatgatgcga ccaaaacctt taccgttacc 3120
gaataataat ctagaaggag gaacaatatg atccgcttca aaaagaccaa actgattgcg 3180
agcattgcga tggcactgtg tctgttctcc cagccggtga tttcgttctc aaaagatatt 3240
accgacaaaa atcagtccat cgattcaggc attagctctc tgtcttataa ccgtaatgaa 3300
gtgctggcgt ccaatggtga caaaatcgaa tcatttgttc cgaaagaagg caaaaaagcc 3360
ggtaacaaat tcattgtggt tgaacgtcag aaacgctctc tgaccacgag tccggttgat 3420
atctccatta tcgattcagt caatgaccgt acctatccgg gtgcactgca actggcagac 3480
aaagcatttg tggaaaaccg tccgacgatt ctgatggtta aacgcaaacc gattaacatc 3540
aatattgatc tgccgggcct gaaaggtgaa aatagtatca aagtggatga cccgacctat 3600
ggcaaagttt cgggtgcaat tgatgaactg gtcagcaaat ggaacgaaaa atacagttcc 3660
acccatacgc tgccggcgcg tacccagtat tcggaaagca tggtgtactc taaaagtcaa 3720
atctcatcgg cgctgaacgt taatgccaaa gtcctggaaa actctctggg tgtggatttt 3780
aatgcggttg ccaacaatga gaaaaaagtg atgatcctgg catataaaca gattttctac 3840
accgttagtg ctgatctgcc gaaaaacccg tctgacctgt ttgatgacag tgtcacgttc 3900
aacgatctga aacaaaaagg cgtgtctaat gaagcgccgc cgctgatggt gtctaacgtt 3960
gcctatggtc gtaccattta cgttaaactg gaaaccacga gctctagtaa agatgtccag 4020
gcggccttta aagccctgat caaaaacacc gatatcaaaa atagccagca atacaaagac 4080
atctacgaaa attcctcatt caccgcagtc gtgctgggcg gtgatgctca ggaacacaac 4140
aaagttgtca cgaaagattt tgacgaaatc cgcaaagtga ttaaagataa cgcaaccttc 4200
tcgacgaaaa atccggctta tccgatttcg tacaccagcg tttttctgaa agataacagc 4260
gtcgcagctg tgcataataa aaccgactat atcgaaacca ccagcaccga atacagcaaa 4320
ggcaaaatta atctggatca ctccggtgca tatgtcgctc agttcgaagt ggcctgggat 4380
gaagtttcat acgacaaaga aggcaatgaa gtgctgaccc ataaaacgtg ggatggtaac 4440
tatcaagaca aaaccgcaca ctactccacg gttattccgc tggaagcaaa cgctcgtaat 4500
atccgcatta aagcgcgtga atgcaccggt ctggcatggg aatggtggcg tgatgtcatc 4560
agcgaatatg acgtgccgct gacgaacaat atcaatgtgt caatctgggg caccacgctg 4620
tatccgggta gttccatcac ctataattaa taaggatcca ggaggattac tatatgggtc 4680
tggataccgt gagcttctcg acgaaaggcg caacctacat tacctacgtg aacttcctga 4740
acgaactgcg tgtgaaactg aaaccggaag gcaacagcca tggtatcccg ctgctgcgta 4800
aaaaatgcga tgacccgggc aaatgttttg ttctggtcgc actgagtaac gataatggtc 4860
agctggcaga aattgctatc gacgtgacct cagtttatgt ggttggctac caagtccgta 4920
accgctcgta tttctttaaa gatgcaccgg acgcggccta cgaaggtctg tttaaaaata 4980
ccatcaaaac gcgcctgcac ttcggcggta gttatccgtc cctggaaggc gaaaaagcgt 5040
atcgtgaaac cacggatctg ggcattgaac cgctgcgcat tggtatcaaa aaactggatg 5100
aaaacgcgat tgacaattat aaaccgacgg aaatcgccag ctctctgctg gtcgtgattc 5160
agatggtgtc agaagccgct cgttttacct ttatcgaaaa tcaaatccgc aacaactttc 5220
aacaaagaat tcgcccggct aataatacga tctcgctgga aaataaatgg ggtaaactga 5280
gctttcaaat ccgcacctcg ggcgctaacg gcatgttctc cgaagcggtg gaactggaac 5340
gtgccaacgg caaaaaatat tacgttaccg ctgtggacca ggtgaaaccg aaaatcgctc 5400
tgctgaaatt cgttgataaa gacccgaaat aataaggatc ccctaggggc gcgcctggta 5460
gtgtggggtc tccccatgcg agagtaggga actgccaggc atcaaataaa acgaaaggct 5520
cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc tctcctgagt 5580
aggacaaatc cgccgggagc ggatttgaac gttgcgaagc aacggcccgg agggtggcgg 5640
gcaggacgcc cgccataaac tgccaggcat caaattaagc agaaggccat cctgacggat 5700
ggcctttttg cgtttctaca aactcgagct cgaattcgta atcatggtca tagctgtttc 5760
ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt 5820
gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc 5880
ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg 5940
ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct 6000
cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca 6060
cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aagcccagga 6120
accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc 6180
acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg 6240
cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat 6300
acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt 6360
atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc 6420
agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg 6480
acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg 6540
gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg 6600
gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg 6660
gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca 6720
gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga 6780
acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga 6840
tccttttaaa ttaaaaatga agttttagca cgtgctatta ttgaagcatt tatcagggtt 6900
attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc 6960
cgcgcacatt tccccgaaaa gtgccacctg tatgcggtgt gaaataccgc acagatgcgt 7020
aaggagaaaa taccgcatca ggaaattgta agcgttaata attcagaaga actcgtcaag 7080
aaggcgatag aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa gcacgaggaa 7140
gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca acgctatgtc 7200
ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa agcggccatt 7260
ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat cctcgccgtc 7320
gggcatgctc gccttgagcc tggcgaacag ttcggctggc gcgagcccct gatgctcttc 7380
gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc gctcgatgcg 7440
atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca gccgccgcat 7500
tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg 7560
ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa cgtcgagcac 7620
agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct cgtcttgcag 7680
ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc cctgcgctga 7740
cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt catagccgaa 7800
tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt caatcatgcg 7860
aaacgatcct catcctgtct cttgatcaga gcttgatccc ctgcgccatc agatccttgg 7920
cggcgagaaa gccatccagt ttactttgca gggcttccca accttaccag agggcgcccc 7980
agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtagaagc atatg      8035<210> 22
<211> 444
<212> PRT
<213> Artificial Sequence

<220> 
<223> Lpp-OmpA-Protein G

<400> 22
Met Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr
 1               5                  10                  15      
Leu Leu Ala Gly Cys Ser Ser Asn Ala Lys Ile Asp Gln Gly Ile Asn
            20                  25                  30          
Pro Tyr Val Gly Phe Glu Met Gly Tyr Asp Trp Leu Gly Arg Met Pro
        35                  40                  45              
Tyr Lys Gly Ser Val Glu Asn Gly Ala Tyr Lys Ala Gln Gly Val Gln
    50                  55                  60                  
Leu Thr Ala Lys Leu Gly Tyr Pro Ile Thr Asp Asp Leu Asp Ile Tyr
65                  70                  75                  80  
Thr Arg Leu Gly Gly Met Val Trp Arg Ala Asp Thr Lys Ser Asn Val
                85                  90                  95      
Tyr Gly Lys Asn His Asp Thr Gly Val Ser Pro Val Phe Ala Gly Gly
            100                 105                 110         
Val Glu Tyr Ala Ile Thr Pro Glu Ile Ala Thr Arg Leu Glu Tyr Gln
        115                 120                 125             
Trp Thr Asn Asn Ile Gly Asp Ala His Thr Ile Gly Thr Arg Pro Asp
    130                 135                 140                 
Asn Gly Ile Pro Gly Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln
145                 150                 155                 160 
Gln Asn Ala Phe Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp
                165                 170                 175     
Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser
            180                 185                 190         
Ala Asn Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro
        195                 200                 205             
Lys Ala Asp Ala Gln Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala
    210                 215                 220                 
Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn
225                 230                 235                 240 
Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val
                245                 250                 255     
Leu Gly Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp
            260                 265                 270         
Asn Asn Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn
        275                 280                 285             
Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu
    290                 295                 300                 
Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys
305                 310                 315                 320 
Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu
                325                 330                 335     
Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu
            340                 345                 350         
Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln
        355                 360                 365             
Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala
    370                 375                 380                 
Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr
385                 390                 395                 400 
Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe
                405                 410                 415     
Ile Gln Ser Leu Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala
            420                 425                 430         
Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys
        435                 440                 


<210> 23
<211> 356
<212> PRT
<213> Artificial Sequence

<220> 
<223> Lpp-OmpA-Protein G

<400> 23
Met Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr
 1               5                  10                  15      
Leu Leu Ala Gly Cys Ser Ser Asn Ala Lys Ile Asp Gln Gly Ile Asn
            20                  25                  30          
Pro Tyr Val Gly Phe Glu Met Gly Tyr Asp Trp Leu Gly Arg Met Pro
        35                  40                  45              
Tyr Lys Gly Ser Val Glu Asn Gly Ala Tyr Lys Ala Gln Gly Val Gln
    50                  55                  60                  
Leu Thr Ala Lys Leu Gly Tyr Pro Ile Thr Asp Asp Leu Asp Ile Tyr
65                  70                  75                  80  
Thr Arg Leu Gly Gly Met Val Trp Arg Ala Asp Thr Lys Ser Asn Val
                85                  90                  95      
Tyr Gly Lys Asn His Asp Thr Gly Val Ser Pro Val Phe Ala Gly Gly
            100                 105                 110         
Val Glu Tyr Ala Ile Thr Pro Glu Ile Ala Thr Arg Leu Glu Tyr Gln
        115                 120                 125             
Trp Thr Asn Asn Ile Gly Asp Ala His Thr Ile Gly Thr Arg Pro Asp
    130                 135                 140                 
Asn Gly Ile Pro Gly Ile Asp Glu Ile Leu Ala Ala Leu Pro Lys Thr
145                 150                 155                 160 
Asp Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr
                165                 170                 175     
Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln
            180                 185                 190         
Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala
        195                 200                 205             
Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala Ser
    210                 215                 220                 
Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys
225                 230                 235                 240 
Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala
                245                 250                 255     
Glu Lys Val Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu
            260                 265                 270         
Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro
        275                 280                 285             
Glu Val Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys
    290                 295                 300                 
Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala
305                 310                 315                 320 
Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp
                325                 330                 335     
Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe
            340                 345                 350         
Thr Val Thr Glu
        355     


<210> 24
<211> 252
<212> PRT
<213> Artificial Sequence

<220> 
<223> Gelonin

<400> 24
Met Gly Leu Asp Thr Val Ser Phe Ser Thr Lys Gly Ala Thr Tyr Ile
 1               5                  10                  15      
Thr Tyr Val Asn Phe Leu Asn Glu Leu Arg Val Lys Leu Lys Pro Glu
            20                  25                  30          
Gly Asn Ser His Gly Ile Pro Leu Leu Arg Lys Lys Cys Asp Asp Pro
        35                  40                  45              
Gly Lys Cys Phe Val Leu Val Ala Leu Ser Asn Asp Asn Gly Gln Leu
    50                  55                  60                  
Ala Glu Ile Ala Ile Asp Val Thr Ser Val Tyr Val Val Gly Tyr Gln
65                  70                  75                  80  
Val Arg Asn Arg Ser Tyr Phe Phe Lys Asp Ala Pro Asp Ala Ala Tyr
                85                  90                  95      
Glu Gly Leu Phe Lys Asn Thr Ile Lys Thr Arg Leu His Phe Gly Gly
            100                 105                 110         
Ser Tyr Pro Ser Leu Glu Gly Glu Lys Ala Tyr Arg Glu Thr Thr Asp
        115                 120                 125             
Leu Gly Ile Glu Pro Leu Arg Ile Gly Ile Lys Lys Leu Asp Glu Asn
    130                 135                 140                 
Ala Ile Asp Asn Tyr Lys Pro Thr Glu Ile Ala Ser Ser Leu Leu Val
145                 150                 155                 160 
Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe Thr Phe Ile Glu Asn
                165                 170                 175     
Gln Ile Arg Asn Asn Phe Gln Gln Arg Ile Arg Pro Ala Asn Asn Thr
            180                 185                 190         
Ile Ser Leu Glu Asn Lys Trp Gly Lys Leu Ser Phe Gln Ile Arg Thr
        195                 200                 205             
Ser Gly Ala Asn Gly Met Phe Ser Glu Ala Val Glu Leu Glu Arg Ala
    210                 215                 220                 
Asn Gly Lys Lys Tyr Tyr Val Thr Ala Val Asp Gln Val Lys Pro Lys
225                 230                 235                 240 
Ile Ala Leu Leu Lys Phe Val Asp Lys Asp Pro Lys
                245                 250         


<210> 25
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diphtheria toxin Fragment A with native signal
      sequence

<400> 25
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly
 1               5                  10                  15      
Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Val Asp
            20                  25                  30          
Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr
        35                  40                  45              
Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys
    50                  55                  60                  
Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser
65                  70                  75                  80  
Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn
                85                  90                  95      
Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly
            100                 105                 110         
Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys
        115                 120                 125             
Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly
    130                 135                 140                 
Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val
145                 150                 155                 160 
Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn
                165                 170                 175     
Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe
            180                 185                 190         
Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala
        195                 200                 205             
Gln Ala Cys Ala Gly Asn Arg Val Arg
    210                 215         


<210> 26
<211> 193
<212> PRT
<213> Artificial Sequence

<220> 
<223> Diphtheria toxin Fragment A lacking the native
      signal sequence

<400> 26
Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu
 1               5                  10                  15      
Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile
            20                  25                  30          
Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp
        35                  40                  45              
Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala
    50                  55                  60                  
Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly
65                  70                  75                  80  
Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys
                85                  90                  95      
Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr
            100                 105                 110         
Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe
        115                 120                 125             
Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly
    130                 135                 140                 
Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu
145                 150                 155                 160 
Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln
                165                 170                 175     
Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val
            180                 185                 190         
Arg
    


<210> 27
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> Perfringolysin O

<400> 27
Met Ile Arg Phe Lys Lys Thr Lys Leu Ile Ala Ser Ile Ala Met Ala
 1               5                  10                  15      
Leu Cys Leu Phe Ser Gln Pro Val Ile Ser Phe Ser Lys Asp Ile Thr
            20                  25                  30          
Asp Lys Asn Gln Ser Ile Asp Ser Gly Ile Ser Ser Leu Ser Tyr Asn
        35                  40                  45              
Arg Asn Glu Val Leu Ala Ser Asn Gly Asp Lys Ile Glu Ser Phe Val
    50                  55                  60                  
Pro Lys Glu Gly Lys Lys Ala Gly Asn Lys Phe Ile Val Val Glu Arg
65                  70                  75                  80  
Gln Lys Arg Ser Leu Thr Thr Ser Pro Val Asp Ile Ser Ile Ile Asp
                85                  90                  95      
Ser Val Asn Asp Arg Thr Tyr Pro Gly Ala Leu Gln Leu Ala Asp Lys
            100                 105                 110         
Ala Phe Val Glu Asn Arg Pro Thr Ile Leu Met Val Lys Arg Lys Pro
        115                 120                 125             
Ile Asn Ile Asn Ile Asp Leu Pro Gly Leu Lys Gly Glu Asn Ser Ile
    130                 135                 140                 
Lys Val Asp Asp Pro Thr Tyr Gly Lys Val Ser Gly Ala Ile Asp Glu
145                 150                 155                 160 
Leu Val Ser Lys Trp Asn Glu Lys Tyr Ser Ser Thr His Thr Leu Pro
                165                 170                 175     
Ala Arg Thr Gln Tyr Ser Glu Ser Met Val Tyr Ser Lys Ser Gln Ile
            180                 185                 190         
Ser Ser Ala Leu Asn Val Asn Ala Lys Val Leu Glu Asn Ser Leu Gly
        195                 200                 205             
Val Asp Phe Asn Ala Val Ala Asn Asn Glu Lys Lys Val Met Ile Leu
    210                 215                 220                 
Ala Tyr Lys Gln Ile Phe Tyr Thr Val Ser Ala Asp Leu Pro Lys Asn
225                 230                 235                 240 
Pro Ser Asp Leu Phe Asp Asp Ser Val Thr Phe Asn Asp Leu Lys Gln
                245                 250                 255     
Lys Gly Val Ser Asn Glu Ala Pro Pro Leu Met Val Ser Asn Val Ala
            260                 265                 270         
Tyr Gly Arg Thr Ile Tyr Val Lys Leu Glu Thr Thr Ser Ser Ser Lys
        275                 280                 285             
Asp Val Gln Ala Ala Phe Lys Ala Leu Ile Lys Asn Thr Asp Ile Lys
    290                 295                 300                 
Asn Ser Gln Gln Tyr Lys Asp Ile Tyr Glu Asn Ser Ser Phe Thr Ala
305                 310                 315                 320 
Val Val Leu Gly Gly Asp Ala Gln Glu His Asn Lys Val Val Thr Lys
                325                 330                 335     
Asp Phe Asp Glu Ile Arg Lys Val Ile Lys Asp Asn Ala Thr Phe Ser
            340                 345                 350         
Thr Lys Asn Pro Ala Tyr Pro Ile Ser Tyr Thr Ser Val Phe Leu Lys
        355                 360                 365             
Asp Asn Ser Val Ala Ala Val His Asn Lys Thr Asp Tyr Ile Glu Thr
    370                 375                 380                 
Thr Ser Thr Glu Tyr Ser Lys Gly Lys Ile Asn Leu Asp His Ser Gly
385                 390                 395                 400 
Ala Tyr Val Ala Gln Phe Glu Val Ala Trp Asp Glu Val Ser Tyr Asp
                405                 410                 415     
Lys Glu Gly Asn Glu Val Leu Thr His Lys Thr Trp Asp Gly Asn Tyr
            420                 425                 430         
Gln Asp Lys Thr Ala His Tyr Ser Thr Val Ile Pro Leu Glu Ala Asn
        435                 440                 445             
Ala Arg Asn Ile Arg Ile Lys Ala Arg Glu Cys Thr Gly Leu Ala Trp
    450                 455                 460                 
Glu Trp Trp Arg Asp Val Ile Ser Glu Tyr Asp Val Pro Leu Thr Asn
465                 470                 475                 480 
Asn Ile Asn Val Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gly Ser Ser
                485                 490                 495     
Ile Thr Tyr Asn
            500 


<210> 28
<211> 499
<212> PRT
<213> Artificial Sequence

<220> 
<223> Perfringolysin O

<400> 28
Met Ile Arg Phe Lys Lys Thr Lys Leu Ile Ala Ser Ile Ala Met Ala
 1               5                  10                  15      
Leu Cys Leu Phe Ser Gln Pro Val Ile Ser Phe Ser Lys Asp Ile Thr
            20                  25                  30          
Asp Lys Asn Gln Ser Ile Asp Ser Gly Ile Ser Ser Leu Ser Tyr Asn
        35                  40                  45              
Arg Asn Glu Val Leu Ala Ser Asn Gly Asp Lys Ile Glu Ser Phe Val
    50                  55                  60                  
Pro Lys Glu Gly Lys Lys Ala Gly Asn Lys Phe Ile Val Val Glu Arg
65                  70                  75                  80  
Gln Lys Arg Ser Leu Thr Thr Ser Pro Val Asp Ile Ser Ile Ile Asp
                85                  90                  95      
Ser Val Asn Asp Arg Thr Tyr Pro Gly Ala Leu Gln Leu Ala Asp Lys
            100                 105                 110         
Ala Phe Val Glu Asn Arg Pro Thr Ile Leu Met Val Lys Glu Ala Ile
        115                 120                 125             
Asn Ile Asn Ile Asp Leu Pro Gly Leu Lys Gly Glu Asn Ser Ile Lys
    130                 135                 140                 
Val Asp Asp Pro Thr Tyr Gly Lys Val Ser Gly Ala Ile Asp Glu Leu
145                 150                 155                 160 
Val Ser Lys Trp Asn Glu Lys Tyr Ser Ser Thr His Thr Leu Pro Ala
                165                 170                 175     
Arg Thr Gln Tyr Ser Glu Ser Met Val Tyr Ser Lys Ser Gln Ile Ser
            180                 185                 190         
Ser Ala Leu Asn Val Asn Ala Lys Val Leu Glu Asn Ser Leu Gly Val
        195                 200                 205             
Asp Phe Asn Ala Val Ala Asn Asn Glu Lys Lys Val Met Ile Leu Ala
    210                 215                 220                 
Tyr Lys Gln Ile Phe Tyr Thr Val Ser Ala Asp Leu Pro Lys Asn Pro
225                 230                 235                 240 
Ser Asp Leu Phe Asp Asp Ser Val Thr Phe Asn Asp Leu Lys Gln Lys
                245                 250                 255     
Gly Val Ser Asn Glu Ala Pro Pro Leu Met Val Ser Asn Val Ala Tyr
            260                 265                 270         
Gly Arg Thr Ile Tyr Val Lys Leu Glu Thr Thr Ser Ser Ser Lys Asp
        275                 280                 285             
Val Gln Ala Ala Phe Lys Ala Leu Ile Lys Asn Thr Asp Ile Lys Asn
    290                 295                 300                 
Ser Gln Gln Tyr Lys Asp Ile Tyr Glu Asn Ser Ser Phe Thr Ala Val
305                 310                 315                 320 
Val Leu Gly Gly Asp Ala Gln Glu His Asn Lys Val Val Thr Lys Asp
                325                 330                 335     
Phe Asp Glu Ile Arg Lys Val Ile Lys Asp Asn Ala Thr Phe Ser Thr
            340                 345                 350         
Lys Asn Pro Ala Tyr Pro Ile Ser Tyr Thr Ser Val Phe Leu Lys Asp
        355                 360                 365             
Asn Ser Val Ala Ala Val His Asn Lys Thr Asp Tyr Ile Glu Thr Thr
    370                 375                 380                 
Ser Thr Glu Tyr Ser Lys Gly Lys Ile Asn Leu Asp His Ser Gly Ala
385                 390                 395                 400 
Tyr Val Ala Gln Phe Glu Val Ala Trp Asp Glu Val Ser Tyr Asp Lys
                405                 410                 415     
Glu Gly Asn Glu Val Leu Thr His Lys Thr Trp Asp Gly Asn Tyr Gln
            420                 425                 430         
Asp Lys Thr Ala His Tyr Ser Thr Val Ile Pro Leu Glu Ala Asn Ala
        435                 440                 445             
Arg Asn Ile Arg Ile Lys Ala Arg Glu Cys Thr Gly Leu Ala Trp Glu
    450                 455                 460                 
Trp Trp Arg Asp Val Ile Ser Glu Tyr Asp Val Pro Leu Thr Asn Asn
465                 470                 475                 480 
Ile Asn Val Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gly Ser Ser Ile
                485                 490                 495     
Thr Tyr Asn
            


<210> 29
<211> 529
<212> PRT
<213> Listeria monocytogenes

<220> 
<223> Listeriolysin O

<400> 29
Met Lys Lys Leu Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu
 1               5                  10                  15      
Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys
            20                  25                  30          
Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser
        35                  40                  45              
Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr
    50                  55                  60                  
Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly
65                  70                  75                  80  
Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn
                85                  90                  95      
Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn
            100                 105                 110         
Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly
        115                 120                 125             
Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val
    130                 135                 140                 
Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly
145                 150                 155                 160 
Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser
                165                 170                 175     
Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys
            180                 185                 190         
Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp
        195                 200                 205             
Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala
    210                 215                 220                 
Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser
225                 230                 235                 240 
Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr
                245                 250                 255     
Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys
            260                 265                 270         
Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn
        275                 280                 285             
Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu
    290                 295                 300                 
Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp
305                 310                 315                 320 
Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn
                325                 330                 335     
Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala
            340                 345                 350         
Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp
        355                 360                 365             
Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro
    370                 375                 380                 
Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile
385                 390                 395                 400 
Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp
                405                 410                 415     
Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn
            420                 425                 430         
Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val
        435                 440                 445             
Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe
    450                 455                 460                 
Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr
465                 470                 475                 480 
Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile
                485                 490                 495     
Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp
            500                 505                 510         
Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile
        515                 520                 525             
Glu
    


<210> 30
<211> 504
<212> PRT
<213> Listeria monocytogenes

<220> 
<223> Listeriolysin O lacking signal sequence

<400> 30
Met Ser Ala Phe Asn Lys Glu Asn Ser Ile Ser Ser Met Ala Pro Pro
 1               5                  10                  15      
Ala Ser Pro Pro Ala Ser Pro Lys Thr Pro Ile Glu Lys Lys His Ala
            20                  25                  30          
Asp Glu Ile Asp Lys Tyr Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn
        35                  40                  45              
Val Leu Val Tyr His Gly Asp Ala Val Thr Asn Val Pro Pro Arg Lys
    50                  55                  60                  
Gly Tyr Lys Asp Gly Asn Glu Tyr Ile Val Val Glu Lys Lys Lys Lys
65                  70                  75                  80  
Ser Ile Asn Gln Asn Asn Ala Asp Ile Gln Val Val Asn Ala Ile Ser
                85                  90                  95      
Ser Leu Thr Tyr Pro Gly Ala Leu Val Lys Ala Asn Ser Glu Leu Val
            100                 105                 110         
Glu Asn Gln Pro Asp Val Leu Pro Val Lys Arg Asp Ser Leu Thr Leu
        115                 120                 125             
Ser Ile Asp Leu Pro Gly Met Thr Asn Gln Asp Asn Lys Ile Val Val
    130                 135                 140                 
Lys Asn Ala Thr Lys Ser Asn Val Asn Asn Ala Val Asn Thr Leu Val
145                 150                 155                 160 
Glu Arg Trp Asn Glu Lys Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala
                165                 170                 175     
Lys Ile Asp Tyr Asp Asp Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile
            180                 185                 190         
Ala Lys Phe Gly Thr Ala Phe Lys Ala Val Asn Asn Ser Leu Asn Val
        195                 200                 205             
Asn Phe Gly Ala Ile Ser Glu Gly Lys Met Gln Glu Glu Val Ile Ser
    210                 215                 220                 
Phe Lys Gln Ile Tyr Tyr Asn Val Asn Val Asn Glu Pro Thr Arg Pro
225                 230                 235                 240 
Ser Arg Phe Phe Gly Lys Ala Val Thr Lys Glu Gln Leu Gln Ala Leu
                245                 250                 255     
Gly Val Asn Ala Glu Asn Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr
            260                 265                 270         
Gly Arg Gln Val Tyr Leu Lys Leu Ser Thr Asn Ser His Ser Thr Lys
        275                 280                 285             
Val Lys Ala Ala Phe Asp Ala Ala Val Ser Gly Lys Ser Val Ser Gly
    290                 295                 300                 
Asp Val Glu Leu Thr Asn Ile Ile Lys Asn Ser Ser Phe Lys Ala Val
305                 310                 315                 320 
Ile Tyr Gly Gly Ser Ala Lys Asp Glu Val Gln Ile Ile Asp Gly Asn
                325                 330                 335     
Leu Gly Asp Leu Arg Asp Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg
            340                 345                 350         
Glu Thr Pro Gly Val Pro Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp
        355                 360                 365             
Asn Glu Leu Ala Val Ile Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr
    370                 375                 380                 
Ser Lys Ala Tyr Thr Asp Gly Lys Ile Asn Ile Asp His Ser Gly Gly
385                 390                 395                 400 
Tyr Val Ala Gln Phe Asn Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro
                405                 410                 415     
Glu Gly Asn Glu Ile Val Gln His Lys Asn Trp Ser Glu Asn Asn Lys
            420                 425                 430         
Ser Lys Leu Ala His Phe Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala
        435                 440                 445             
Arg Asn Ile Asn Val Tyr Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu
    450                 455                 460                 
Trp Trp Arg Thr Val Ile Asp Asp Arg Asn Leu Pro Leu Val Lys Asn
465                 470                 475                 480 
Arg Asn Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn
                485                 490                 495     
Lys Val Asp Asn Pro Ile Glu Tyr
            500                 


<210> 31
<211> 529
<212> PRT
<213> Artificial Sequence

<220> 
<223> Listeriolysin O (stabilized; sLLO)

<400> 31
Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu
 1               5                  10                  15      
Pro Ile Ala Gln Gln Thr Glu Ala Gly Asp Ala Ser Ala Phe Asn Lys
            20                  25                  30          
Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser
        35                  40                  45              
Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr
    50                  55                  60                  
Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly
65                  70                  75                  80  
Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn
                85                  90                  95      
Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn
            100                 105                 110         
Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly
        115                 120                 125             
Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val
    130                 135                 140                 
Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly
145                 150                 155                 160 
Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser
                165                 170                 175     
Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys
            180                 185                 190         
Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp
        195                 200                 205             
Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala
    210                 215                 220                 
Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser
225                 230                 235                 240 
Glu Gly Lys Met Gln Glu Met Val Ile Ser Phe Lys Gln Ile Tyr Tyr
                245                 250                 255     
Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys
            260                 265                 270         
Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn
        275                 280                 285             
Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu
    290                 295                 300                 
Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Lys
305                 310                 315                 320 
Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn
                325                 330                 335     
Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala
            340                 345                 350         
Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp
        355                 360                 365             
Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro
    370                 375                 380                 
Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile
385                 390                 395                 400 
Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp
                405                 410                 415     
Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn
            420                 425                 430         
Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val
        435                 440                 445             
Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe
    450                 455                 460                 
Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr
465                 470                 475                 480 
Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile
                485                 490                 495     
Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp
            500                 505                 510         
Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile
        515                 520                 525             
Glu
    


<210> 32
<211> 529
<212> PRT
<213> Artificial Sequence

<220> 
<223> Listeriolysin O (pH-stabilized; sLLOpH)

<400> 32
Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu
 1               5                  10                  15      
Pro Ile Ala Gln Gln Thr Glu Ala Gly Asp Ala Ser Ala Phe Asn Lys
            20                  25                  30          
Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser
        35                  40                  45              
Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr
    50                  55                  60                  
Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly
65                  70                  75                  80  
Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn
                85                  90                  95      
Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn
            100                 105                 110         
Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly
        115                 120                 125             
Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val
    130                 135                 140                 
Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly
145                 150                 155                 160 
Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser
                165                 170                 175     
Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys
            180                 185                 190         
Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp
        195                 200                 205             
Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala
    210                 215                 220                 
Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser
225                 230                 235                 240 
Glu Gly Lys Met Gln Glu Met Val Ile Ser Phe Lys Gln Ile Tyr Tyr
                245                 250                 255     
Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys
            260                 265                 270         
Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn
        275                 280                 285             
Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu
    290                 295                 300                 
Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Lys
305                 310                 315                 320 
Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn
                325                 330                 335     
Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala
            340                 345                 350         
Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp
        355                 360                 365             
Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro
    370                 375                 380                 
Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile
385                 390                 395                 400 
Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp
                405                 410                 415     
Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn
            420                 425                 430         
Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val
        435                 440                 445             
Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Thr Ala His Phe
    450                 455                 460                 
Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr
465                 470                 475                 480 
Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile
                485                 490                 495     
Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp
            500                 505                 510         
Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile
        515                 520                 525             
Glu
    


<210> 33
<211> 1503
<212> DNA
<213> Artificial Sequence

<220> 
<223> PFOs L462F (PFOf)

<400> 33
atgatccgct tcaaaaagac caaactgatt gcgagcattg cgatggcact gtgtctgttc 60
tcccagccgg tgatttcgtt ctcaaaagat attaccgaca aaaatcagtc catcgattca 120
ggcattagct ctctgtctta taaccgtaat gaagtgctgg cgtccaatgg tgacaaaatc 180
gaatcatttg ttccgaaaga aggcaaaaaa gccggtaaca aattcattgt ggttgaacgt 240
cagaaacgct ctctgaccac gagtccggtt gatatctcca ttatcgattc agtcaatgac 300
cgtacctatc cgggtgcact gcaactggca gacaaagcat ttgtggaaaa ccgtccgacg 360
attctgatgg ttaaacgcaa accgattaac atcaatattg atctgccggg cctgaaaggt 420
gaaaatagta tcaaagtgga tgacccgacc tatggcaaag tttcgggtgc aattgatgaa 480
ctggtcagca aatggaacga aaaatacagt tccacccata cgctgccggc gcgtacccag 540
tattcggaaa gcatggtgta ctctaaaagt caaatctcat cggcgctgaa cgttaatgcc 600
aaagtcctgg aaaactctct gggtgtggat tttaatgcgg ttgccaacaa tgagaaaaaa 660
gtgatgatcc tggcatataa acagattttc tacaccgtta gtgctgatct gccgaaaaac 720
ccgtctgacc tgtttgatga cagtgtcacg ttcaacgatc tgaaacaaaa aggcgtgtct 780
aatgaagcgc cgccgctgat ggtgtctaac gttgcctatg gtcgtaccat ttacgttaaa 840
ctggaaacca cgtctagcag taaagatgtc caggcggcct ttaaagccct gatcaaaaac 900
accgatatca aaaatagcca gcaatacaaa gacatctacg aaaattcctc attcaccgca 960
gtcgtgctgg gcggtgatgc tcaggaacac aacaaagttg tcacgaaaga ttttgacgaa 1020
atccgcaaag tgattaaaga taacgcaacc ttctcgacga aaaatccggc ttatccgatt 1080
tcgtacacca gcgtttttct gaaagataac agcgtcgcag ctgtgcataa taaaaccgac 1140
tatatcgaaa ccaccagcac cgaatacagc aaaggcaaaa ttaatctgga tcactccggt 1200
gcatatgtcg ctcagttcga agtggcctgg gatgaagttt catacgacaa agaaggcaat 1260
gaagtgctga cccataaaac gtgggatggt aactatcaag acaaaaccgc acactactcc 1320
acggttattc cgctggaagc aaacgctcgt aatatccgca ttaaagcgcg tgaatgcacc 1380
ggttttgcat gggaatggtg gcgtgatgtc atcagcgaat atgacgtgcc gctgacgaac 1440
aatatcaatg tgtcaatctg gggcaccacg ctgtatccgg gtagttccat cacctataat 1500
taa                                                               1503

<210> 34
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> PFOs L462F (PFOf)

<400> 34
Met Ile Arg Phe Lys Lys Thr Lys Leu Ile Ala Ser Ile Ala Met Ala
 1               5                  10                  15      
Leu Cys Leu Phe Ser Gln Pro Val Ile Ser Phe Ser Lys Asp Ile Thr
            20                  25                  30          
Asp Lys Asn Gln Ser Ile Asp Ser Gly Ile Ser Ser Leu Ser Tyr Asn
        35                  40                  45              
Arg Asn Glu Val Leu Ala Ser Asn Gly Asp Lys Ile Glu Ser Phe Val
    50                  55                  60                  
Pro Lys Glu Gly Lys Lys Ala Gly Asn Lys Phe Ile Val Val Glu Arg
65                  70                  75                  80  
Gln Lys Arg Ser Leu Thr Thr Ser Pro Val Asp Ile Ser Ile Ile Asp
                85                  90                  95      
Ser Val Asn Asp Arg Thr Tyr Pro Gly Ala Leu Gln Leu Ala Asp Lys
            100                 105                 110         
Ala Phe Val Glu Asn Arg Pro Thr Ile Leu Met Val Lys Arg Lys Pro
        115                 120                 125             
Ile Asn Ile Asn Ile Asp Leu Pro Gly Leu Lys Gly Glu Asn Ser Ile
    130                 135                 140                 
Lys Val Asp Asp Pro Thr Tyr Gly Lys Val Ser Gly Ala Ile Asp Glu
145                 150                 155                 160 
Leu Val Ser Lys Trp Asn Glu Lys Tyr Ser Ser Thr His Thr Leu Pro
                165                 170                 175     
Ala Arg Thr Gln Tyr Ser Glu Ser Met Val Tyr Ser Lys Ser Gln Ile
            180                 185                 190         
Ser Ser Ala Leu Asn Val Asn Ala Lys Val Leu Glu Asn Ser Leu Gly
        195                 200                 205             
Val Asp Phe Asn Ala Val Ala Asn Asn Glu Lys Lys Val Met Ile Leu
    210                 215                 220                 
Ala Tyr Lys Gln Ile Phe Tyr Thr Val Ser Ala Asp Leu Pro Lys Asn
225                 230                 235                 240 
Pro Ser Asp Leu Phe Asp Asp Ser Val Thr Phe Asn Asp Leu Lys Gln
                245                 250                 255     
Lys Gly Val Ser Asn Glu Ala Pro Pro Leu Met Val Ser Asn Val Ala
            260                 265                 270         
Tyr Gly Arg Thr Ile Tyr Val Lys Leu Glu Thr Thr Ser Ser Ser Lys
        275                 280                 285             
Asp Val Gln Ala Ala Phe Lys Ala Leu Ile Lys Asn Thr Asp Ile Lys
    290                 295                 300                 
Asn Ser Gln Gln Tyr Lys Asp Ile Tyr Glu Asn Ser Ser Phe Thr Ala
305                 310                 315                 320 
Val Val Leu Gly Gly Asp Ala Gln Glu His Asn Lys Val Val Thr Lys
                325                 330                 335     
Asp Phe Asp Glu Ile Arg Lys Val Ile Lys Asp Asn Ala Thr Phe Ser
            340                 345                 350         
Thr Lys Asn Pro Ala Tyr Pro Ile Ser Tyr Thr Ser Val Phe Leu Lys
        355                 360                 365             
Asp Asn Ser Val Ala Ala Val His Asn Lys Thr Asp Tyr Ile Glu Thr
    370                 375                 380                 
Thr Ser Thr Glu Tyr Ser Lys Gly Lys Ile Asn Leu Asp His Ser Gly
385                 390                 395                 400 
Ala Tyr Val Ala Gln Phe Glu Val Ala Trp Asp Glu Val Ser Tyr Asp
                405                 410                 415     
Lys Glu Gly Asn Glu Val Leu Thr His Lys Thr Trp Asp Gly Asn Tyr
            420                 425                 430         
Gln Asp Lys Thr Ala His Tyr Ser Thr Val Ile Pro Leu Glu Ala Asn
        435                 440                 445             
Ala Arg Asn Ile Arg Ile Lys Ala Arg Glu Cys Thr Gly Phe Ala Trp
    450                 455                 460                 
Glu Trp Trp Arg Asp Val Ile Ser Glu Tyr Asp Val Pro Leu Thr Asn
465                 470                 475                 480 
Asn Ile Asn Val Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gly Ser Ser
                485                 490                 495     
Ile Thr Tyr Asn
            500 


<210> 35
<211> 1503
<212> DNA
<213> Artificial Sequence

<220> 
<223> PFOsG137Q (PFOq)

<400> 35
atgatccgct tcaaaaagac caaactgatt gcgagcattg cgatggcact gtgtctgttc 60
tcccagccgg tgatttcgtt ctcaaaagat attaccgaca aaaatcagtc catcgattca 120
ggcattagct ctctgtctta taaccgtaat gaagtgctgg cgtccaatgg tgacaaaatc 180
gaatcatttg ttccgaaaga aggcaaaaaa gccggtaaca aattcattgt ggttgaacgt 240
cagaaacgct ctctgaccac gagtccggtt gatatctcca ttatcgattc agtcaatgac 300
cgtacctatc cgggtgcact gcaactggca gacaaagcat ttgtggaaaa ccgtccgacg 360
attctgatgg ttaaacgcaa accgattaac atcaatattg atctgccgca gctgaaaggt 420
gaaaatagta tcaaagtgga tgacccgacc tatggcaaag tttcgggtgc aattgatgaa 480
ctggtcagca aatggaacga aaaatacagt tccacccata cgctgccggc gcgtacccag 540
tattcggaaa gcatggtgta ctctaaaagt caaatctcat cggcgctgaa cgttaatgcc 600
aaagtcctgg aaaactctct gggtgtggat tttaatgcgg ttgccaacaa tgagaaaaaa 660
gtgatgatcc tggcatataa acagattttc tacaccgtta gtgctgatct gccgaaaaac 720
ccgtctgacc tgtttgatga cagtgtcacg ttcaacgatc tgaaacaaaa aggcgtgtct 780
aatgaagcgc cgccgctgat ggtgtctaac gttgcctatg gtcgtaccat ttacgttaaa 840
ctggaaacca cgtctagcag taaagatgtc caggcggcct ttaaagccct gatcaaaaac 900
accgatatca aaaatagcca gcaatacaaa gacatctacg aaaattcctc attcaccgca 960
gtcgtgctgg gcggtgatgc tcaggaacac aacaaagttg tcacgaaaga ttttgacgaa 1020
atccgcaaag tgattaaaga taacgcaacc ttctcgacga aaaatccggc ttatccgatt 1080
tcgtacacca gcgtttttct gaaagataac agcgtcgcag ctgtgcataa taaaaccgac 1140
tatatcgaaa ccaccagcac cgaatacagc aaaggcaaaa ttaatctgga tcactccggt 1200
gcatatgtcg ctcagttcga agtggcctgg gatgaagttt catacgacaa agaaggcaat 1260
gaagtgctga cccataaaac gtgggatggt aactatcaag acaaaaccgc acactactcc 1320
acggttattc cgctggaagc aaacgctcgt aatatccgca ttaaagcgcg tgaatgcacc 1380
ggtctggcat gggaatggtg gcgtgatgtc atcagcgaat atgacgtgcc gctgacgaac 1440
aatatcaatg tgtcaatctg gggcaccacg ctgtatccgg gtagttccat cacctataat 1500
taa                                                               1503

<210> 36
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> PFOsG137Q (PFOq)

<400> 36
Met Ile Arg Phe Lys Lys Thr Lys Leu Ile Ala Ser Ile Ala Met Ala
 1               5                  10                  15      
Leu Cys Leu Phe Ser Gln Pro Val Ile Ser Phe Ser Lys Asp Ile Thr
            20                  25                  30          
Asp Lys Asn Gln Ser Ile Asp Ser Gly Ile Ser Ser Leu Ser Tyr Asn
        35                  40                  45              
Arg Asn Glu Val Leu Ala Ser Asn Gly Asp Lys Ile Glu Ser Phe Val
    50                  55                  60                  
Pro Lys Glu Gly Lys Lys Ala Gly Asn Lys Phe Ile Val Val Glu Arg
65                  70                  75                  80  
Gln Lys Arg Ser Leu Thr Thr Ser Pro Val Asp Ile Ser Ile Ile Asp
                85                  90                  95      
Ser Val Asn Asp Arg Thr Tyr Pro Gly Ala Leu Gln Leu Ala Asp Lys
            100                 105                 110         
Ala Phe Val Glu Asn Arg Pro Thr Ile Leu Met Val Lys Arg Lys Pro
        115                 120                 125             
Ile Asn Ile Asn Ile Asp Leu Pro Gln Leu Lys Gly Glu Asn Ser Ile
    130                 135                 140                 
Lys Val Asp Asp Pro Thr Tyr Gly Lys Val Ser Gly Ala Ile Asp Glu
145                 150                 155                 160 
Leu Val Ser Lys Trp Asn Glu Lys Tyr Ser Ser Thr His Thr Leu Pro
                165                 170                 175     
Ala Arg Thr Gln Tyr Ser Glu Ser Met Val Tyr Ser Lys Ser Gln Ile
            180                 185                 190         
Ser Ser Ala Leu Asn Val Asn Ala Lys Val Leu Glu Asn Ser Leu Gly
        195                 200                 205             
Val Asp Phe Asn Ala Val Ala Asn Asn Glu Lys Lys Val Met Ile Leu
    210                 215                 220                 
Ala Tyr Lys Gln Ile Phe Tyr Thr Val Ser Ala Asp Leu Pro Lys Asn
225                 230                 235                 240 
Pro Ser Asp Leu Phe Asp Asp Ser Val Thr Phe Asn Asp Leu Lys Gln
                245                 250                 255     
Lys Gly Val Ser Asn Glu Ala Pro Pro Leu Met Val Ser Asn Val Ala
            260                 265                 270         
Tyr Gly Arg Thr Ile Tyr Val Lys Leu Glu Thr Thr Ser Ser Ser Lys
        275                 280                 285             
Asp Val Gln Ala Ala Phe Lys Ala Leu Ile Lys Asn Thr Asp Ile Lys
    290                 295                 300                 
Asn Ser Gln Gln Tyr Lys Asp Ile Tyr Glu Asn Ser Ser Phe Thr Ala
305                 310                 315                 320 
Val Val Leu Gly Gly Asp Ala Gln Glu His Asn Lys Val Val Thr Lys
                325                 330                 335     
Asp Phe Asp Glu Ile Arg Lys Val Ile Lys Asp Asn Ala Thr Phe Ser
            340                 345                 350         
Thr Lys Asn Pro Ala Tyr Pro Ile Ser Tyr Thr Ser Val Phe Leu Lys
        355                 360                 365             
Asp Asn Ser Val Ala Ala Val His Asn Lys Thr Asp Tyr Ile Glu Thr
    370                 375                 380                 
Thr Ser Thr Glu Tyr Ser Lys Gly Lys Ile Asn Leu Asp His Ser Gly
385                 390                 395                 400 
Ala Tyr Val Ala Gln Phe Glu Val Ala Trp Asp Glu Val Ser Tyr Asp
                405                 410                 415     
Lys Glu Gly Asn Glu Val Leu Thr His Lys Thr Trp Asp Gly Asn Tyr
            420                 425                 430         
Gln Asp Lys Thr Ala His Tyr Ser Thr Val Ile Pro Leu Glu Ala Asn
        435                 440                 445             
Ala Arg Asn Ile Arg Ile Lys Ala Arg Glu Cys Thr Gly Leu Ala Trp
    450                 455                 460                 
Glu Trp Trp Arg Asp Val Ile Ser Glu Tyr Asp Val Pro Leu Thr Asn
465                 470                 475                 480 
Asn Ile Asn Val Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gly Ser Ser
                485                 490                 495     
Ile Thr Tyr Asn
            500 


<210> 37
<211> 1503
<212> DNA
<213> Artificial Sequence

<220> 
<223> PFOsH438Y (PFOy)

<400> 37
atgatccgct tcaaaaagac caaactgatt gcgagcattg cgatggcact gtgtctgttc 60
tcccagccgg tgatttcgtt ctcaaaagat attaccgaca aaaatcagtc catcgattca 120
ggcattagct ctctgtctta taaccgtaat gaagtgctgg cgtccaatgg tgacaaaatc 180
gaatcatttg ttccgaaaga aggcaaaaaa gccggtaaca aattcattgt ggttgaacgt 240
cagaaacgct ctctgaccac gagtccggtt gatatctcca ttatcgattc agtcaatgac 300
cgtacctatc cgggtgcact gcaactggca gacaaagcat ttgtggaaaa ccgtccgacg 360
attctgatgg ttaaacgcaa accgattaac atcaatattg atctgccggg cctgaaaggt 420
gaaaatagta tcaaagtgga tgacccgacc tatggcaaag tttcgggtgc aattgatgaa 480
ctggtcagca aatggaacga aaaatacagt tccacccata cgctgccggc gcgtacccag 540
tattcggaaa gcatggtgta ctctaaaagt caaatctcat cggcgctgaa cgttaatgcc 600
aaagtcctgg aaaactctct gggtgtggat tttaatgcgg ttgccaacaa tgagaaaaaa 660
gtgatgatcc tggcatataa acagattttc tacaccgtta gtgctgatct gccgaaaaac 720
ccgtctgacc tgtttgatga cagtgtcacg ttcaacgatc tgaaacaaaa aggcgtgtct 780
aatgaagcgc cgccgctgat ggtgtctaac gttgcctatg gtcgtaccat ttacgttaaa 840
ctggaaacca cgtctagcag taaagatgtc caggcggcct ttaaagccct gatcaaaaac 900
accgatatca aaaatagcca gcaatacaaa gacatctacg aaaattcctc attcaccgca 960
gtcgtgctgg gcggtgatgc tcaggaacac aacaaagttg tcacgaaaga ttttgacgaa 1020
atccgcaaag tgattaaaga taacgcaacc ttctcgacga aaaatccggc ttatccgatt 1080
tcgtacacca gcgtttttct gaaagataac agcgtcgcag ctgtgcataa taaaaccgac 1140
tatatcgaaa ccaccagcac cgaatacagc aaaggcaaaa ttaatctgga tcactccggt 1200
gcatatgtcg ctcagttcga agtggcctgg gatgaagttt catacgacaa agaaggcaat 1260
gaagtgctga cccataaaac gtgggatggt aactatcaag acaaaaccgc atattactcc 1320
acggttattc cgctggaagc aaacgctcgt aatatccgca ttaaagcgcg tgaatgcacc 1380
ggtctggcat gggaatggtg gcgtgatgtc atcagcgaat atgacgtgcc gctgacgaac 1440
aatatcaatg tgtcaatctg gggcaccacg ctgtatccgg gtagttccat cacctataat 1500
taa                                                               1503

<210> 38
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> PFOsH438Y (PFOy)

<400> 38
Met Ile Arg Phe Lys Lys Thr Lys Leu Ile Ala Ser Ile Ala Met Ala
 1               5                  10                  15      
Leu Cys Leu Phe Ser Gln Pro Val Ile Ser Phe Ser Lys Asp Ile Thr
            20                  25                  30          
Asp Lys Asn Gln Ser Ile Asp Ser Gly Ile Ser Ser Leu Ser Tyr Asn
        35                  40                  45              
Arg Asn Glu Val Leu Ala Ser Asn Gly Asp Lys Ile Glu Ser Phe Val
    50                  55                  60                  
Pro Lys Glu Gly Lys Lys Ala Gly Asn Lys Phe Ile Val Val Glu Arg
65                  70                  75                  80  
Gln Lys Arg Ser Leu Thr Thr Ser Pro Val Asp Ile Ser Ile Ile Asp
                85                  90                  95      
Ser Val Asn Asp Arg Thr Tyr Pro Gly Ala Leu Gln Leu Ala Asp Lys
            100                 105                 110         
Ala Phe Val Glu Asn Arg Pro Thr Ile Leu Met Val Lys Arg Lys Pro
        115                 120                 125             
Ile Asn Ile Asn Ile Asp Leu Pro Gly Leu Lys Gly Glu Asn Ser Ile
    130                 135                 140                 
Lys Val Asp Asp Pro Thr Tyr Gly Lys Val Ser Gly Ala Ile Asp Glu
145                 150                 155                 160 
Leu Val Ser Lys Trp Asn Glu Lys Tyr Ser Ser Thr His Thr Leu Pro
                165                 170                 175     
Ala Arg Thr Gln Tyr Ser Glu Ser Met Val Tyr Ser Lys Ser Gln Ile
            180                 185                 190         
Ser Ser Ala Leu Asn Val Asn Ala Lys Val Leu Glu Asn Ser Leu Gly
        195                 200                 205             
Val Asp Phe Asn Ala Val Ala Asn Asn Glu Lys Lys Val Met Ile Leu
    210                 215                 220                 
Ala Tyr Lys Gln Ile Phe Tyr Thr Val Ser Ala Asp Leu Pro Lys Asn
225                 230                 235                 240 
Pro Ser Asp Leu Phe Asp Asp Ser Val Thr Phe Asn Asp Leu Lys Gln
                245                 250                 255     
Lys Gly Val Ser Asn Glu Ala Pro Pro Leu Met Val Ser Asn Val Ala
            260                 265                 270         
Tyr Gly Arg Thr Ile Tyr Val Lys Leu Glu Thr Thr Ser Ser Ser Lys
        275                 280                 285             
Asp Val Gln Ala Ala Phe Lys Ala Leu Ile Lys Asn Thr Asp Ile Lys
    290                 295                 300                 
Asn Ser Gln Gln Tyr Lys Asp Ile Tyr Glu Asn Ser Ser Phe Thr Ala
305                 310                 315                 320 
Val Val Leu Gly Gly Asp Ala Gln Glu His Asn Lys Val Val Thr Lys
                325                 330                 335     
Asp Phe Asp Glu Ile Arg Lys Val Ile Lys Asp Asn Ala Thr Phe Ser
            340                 345                 350         
Thr Lys Asn Pro Ala Tyr Pro Ile Ser Tyr Thr Ser Val Phe Leu Lys
        355                 360                 365             
Asp Asn Ser Val Ala Ala Val His Asn Lys Thr Asp Tyr Ile Glu Thr
    370                 375                 380                 
Thr Ser Thr Glu Tyr Ser Lys Gly Lys Ile Asn Leu Asp His Ser Gly
385                 390                 395                 400 
Ala Tyr Val Ala Gln Phe Glu Val Ala Trp Asp Glu Val Ser Tyr Asp
                405                 410                 415     
Lys Glu Gly Asn Glu Val Leu Thr His Lys Thr Trp Asp Gly Asn Tyr
            420                 425                 430         
Gln Asp Lys Thr Ala Tyr Tyr Ser Thr Val Ile Pro Leu Glu Ala Asn
        435                 440                 445             
Ala Arg Asn Ile Arg Ile Lys Ala Arg Glu Cys Thr Gly Leu Ala Trp
    450                 455                 460                 
Glu Trp Trp Arg Asp Val Ile Ser Glu Tyr Asp Val Pro Leu Thr Asn
465                 470                 475                 480 
Asn Ile Asn Val Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gly Ser Ser
                485                 490                 495     
Ile Thr Tyr Asn
            500 


<210> 39
<211> 807
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lpp-OmpA-Protein A- 2Fc - No F(ab) binding

<400> 39
atgaaagcta cgaaactggt cctgggtgct gttatcctgg gttctacgct gctggctggc 60
tgttcctcca acgcaaaaat tgatcagggc attaacccgt atgtgggctt tgaaatgggt 120
tacgattggc tgggtcgtat gccgtataaa ggctctgttg aaaatggtgc gtacaaagcc 180
cagggcgtcc aactgaccgc taaactgggt tatccgatta ccgatgacct ggatatctac 240
acgcgtctgg gcggtatggt ctggcgtgcg gataccaaaa gtaacgtgta tggcaaaaat 300
catgacacgg gtgtgtcccc ggttttcgcg ggcggtgttg aatatgccat taccccggaa 360
atcgcaacgc gtctggaata ccagtggacc aacaatattg gcgatgcaca taccatcggt 420
acgcgtccgg acaacggcat cccgggtgca ccgaaagctg ataacaaatt caacaaagaa 480
cagcaaaacg cgttctatga aattctgcac ctgccgaacc tgaatgaaga acagcgtaat 540
gcctttatcc aatcactgaa agatgacccg agccagtctg caaacctgct ggcggaagcc 600
aaaaaactga atgatgcaca ggctccgaaa gctgacaata aatttaataa agaacaacaa 660
aacgcgttct acgaaatcct gcatctgccg aatctgaacg aagaacagcg caatgccttc 720
atccaatcgc tgaaagatga cccgtcacag agtgcgaacc tgctggcgga agctaaaaaa 780
ctgaacgacg ctcaagcccc gaaataa                                     807

<210> 40
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> Lpp-OmpA-Protein A- 2Fc - No F(ab) binding

<400> 40
Met Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr
 1               5                  10                  15      
Leu Leu Ala Gly Cys Ser Ser Asn Ala Lys Ile Asp Gln Gly Ile Asn
            20                  25                  30          
Pro Tyr Val Gly Phe Glu Met Gly Tyr Asp Trp Leu Gly Arg Met Pro
        35                  40                  45              
Tyr Lys Gly Ser Val Glu Asn Gly Ala Tyr Lys Ala Gln Gly Val Gln
    50                  55                  60                  
Leu Thr Ala Lys Leu Gly Tyr Pro Ile Thr Asp Asp Leu Asp Ile Tyr
65                  70                  75                  80  
Thr Arg Leu Gly Gly Met Val Trp Arg Ala Asp Thr Lys Ser Asn Val
                85                  90                  95      
Tyr Gly Lys Asn His Asp Thr Gly Val Ser Pro Val Phe Ala Gly Gly
            100                 105                 110         
Val Glu Tyr Ala Ile Thr Pro Glu Ile Ala Thr Arg Leu Glu Tyr Gln
        115                 120                 125             
Trp Thr Asn Asn Ile Gly Asp Ala His Thr Ile Gly Thr Arg Pro Asp
    130                 135                 140                 
Asn Gly Ile Pro Gly Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu
145                 150                 155                 160 
Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu
                165                 170                 175     
Glu Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln
            180                 185                 190         
Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala
        195                 200                 205             
Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr
    210                 215                 220                 
Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe
225                 230                 235                 240 
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala
                245                 250                 255     
Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys
            260                 265             


<210> 41
<211> 807
<212> DNA
<213> Artificial Sequence

<220> 
<223> Lpp-OmpA-Protein A 2Fc-OTR (OmpT resistant) - No
      F(ab) binding

<400> 41
atgaaagcaa cgaaactggt tctgggtgcg gttattctgg gtagtacgct gctggctggc 60
tgtagctcta atgcgaaaat tgatcagggc attaacccgt atgtgggctt tgaaatgggt 120
tacgattggc tgggtcgtat gccgtataaa ggctctgttg aaaatggtgc gtacaaagcc 180
cagggcgtcc aactgaccgc taaactgggt tatccgatta ccgatgacct ggatatctac 240
acgcgtctgg gcggtatggt ctggcgtgcg gataccaaaa gtaacgtgta tggcaaaaat 300
catgacacgg gtgtgtcccc ggttttcgcg ggcggtgttg aatatgccat taccccggaa 360
atcgcaacgc gtctggaata ccagtggacc aacaatattg gcgatgcaca taccatcggt 420
acgcgtccgg acaacggcat cccgggtgca ccgaaagctg ataacaaatt caacaaagaa 480
cagcaaaacg cgttctatga aattctgcac ctgccgaacc tgaatgaaga acagcgtaat 540
gcctttatcc aatcactgaa agatgacccg agccagtctg caaacctgct ggcggaagcc 600
cagaaactga atgatgcaca agctccgaaa gctgacaata aatttaataa agaacaacaa 660
aacgcgttct acgaaatcct gcatctgccg aatctgaacg aagaacagcg caatgccttc 720
atccagtcgc tgaaagatga cccgtcacaa agcgcaaatc tgctggcgga agcccaaaaa 780
ctgaacgacg cacaggcacc gaaataa                                     807

<210> 42
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> Lpp-OmpA-Protein A 2Fc-OTR (OmpT resistant) - No
      F(ab) binding

<400> 42
Met Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr
 1               5                  10                  15      
Leu Leu Ala Gly Cys Ser Ser Asn Ala Lys Ile Asp Gln Gly Ile Asn
            20                  25                  30          
Pro Tyr Val Gly Phe Glu Met Gly Tyr Asp Trp Leu Gly Arg Met Pro
        35                  40                  45              
Tyr Lys Gly Ser Val Glu Asn Gly Ala Tyr Lys Ala Gln Gly Val Gln
    50                  55                  60                  
Leu Thr Ala Lys Leu Gly Tyr Pro Ile Thr Asp Asp Leu Asp Ile Tyr
65                  70                  75                  80  
Thr Arg Leu Gly Gly Met Val Trp Arg Ala Asp Thr Lys Ser Asn Val
                85                  90                  95      
Tyr Gly Lys Asn His Asp Thr Gly Val Ser Pro Val Phe Ala Gly Gly
            100                 105                 110         
Val Glu Tyr Ala Ile Thr Pro Glu Ile Ala Thr Arg Leu Glu Tyr Gln
        115                 120                 125             
Trp Thr Asn Asn Ile Gly Asp Ala His Thr Ile Gly Thr Arg Pro Asp
    130                 135                 140                 
Asn Gly Ile Pro Gly Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu
145                 150                 155                 160 
Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu
                165                 170                 175     
Glu Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln
            180                 185                 190         
Ser Ala Asn Leu Leu Ala Glu Ala Gln Lys Leu Asn Asp Ala Gln Ala
        195                 200                 205             
Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr
    210                 215                 220                 
Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe
225                 230                 235                 240 
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala
                245                 250                 255     
Glu Ala Gln Lys Leu Asn Asp Ala Gln Ala Pro Lys
            260                 265             

