                         SEQUENCE LISTING

<110>  ISIS INNOVATION LIMITED
 
<120>  ASSAY

<130>  N.112592A

<150>  GB 1102659.8
<151>  2011-02-15

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Gly Lys Arg Pro Ala Glu Pro Gly Pro Ala Arg Val Gly Lys 
1               5                   10                  15      


Lys Gly Lys Lys Glu Val Met Ala Glu Phe Ser Asp Ala Val Thr Glu 
            20                  25                  30          


Glu Thr Leu Lys Lys Gln Val Ala Glu Ala Trp Ser Arg Arg Thr Pro 
        35                  40                  45              


Phe Ser His Glu Val Ile Val Met Asp Met Asp Pro Phe Leu His Cys 
    50                  55                  60                  


Val Ile Pro Asn Phe Ile Gln Ser Gln Asp Phe Leu Glu Gly Leu Gln 
65                  70                  75                  80  


Lys Glu Leu Met Asn Leu Asp Phe His Glu Lys Tyr Asn Asp Leu Tyr 
                85                  90                  95      


Lys Phe Gln Gln Ser Asp Asp Leu Lys Lys Arg Arg Glu Pro His Ile 
            100                 105                 110         


Ser Thr Leu Arg Lys Ile Leu Phe Glu Asp Phe Arg Ser Trp Leu Ser 
        115                 120                 125             


Asp Ile Ser Lys Ile Asp Leu Glu Ser Thr Ile Asp Met Ser Cys Ala 
    130                 135                 140                 


Lys Tyr Glu Phe Thr Asp Ala Leu Leu Cys His Asp Asp Glu Leu Glu 
145                 150                 155                 160 


Gly Arg Arg Ile Ala Phe Ile Leu Tyr Leu Val Pro Pro Trp Asp Arg 
                165                 170                 175     


Ser Met Gly Gly Thr Leu Asp Leu Tyr Ser Ile Asp Glu His Phe Gln 
            180                 185                 190         


Pro Lys Gln Ile Val Lys Ser Leu Ile Pro Ser Trp Asn Lys Leu Val 
        195                 200                 205             


Phe Phe Glu Val Ser Pro Val Ser Phe His Gln Val Ser Glu Val Leu 
    210                 215                 220                 


Ser Glu Glu Lys Ser Arg Leu Ser Ile Ser Gly Trp Phe His Gly Pro 
225                 230                 235                 240 


Ser Leu Thr Arg Pro Pro Asn Tyr Phe Glu Pro Pro Ile Pro Arg Ser 
                245                 250                 255     


Pro His Ile Pro Gln Asp His Glu Ile Leu Tyr Asp Trp Ile Asn Pro 
            260                 265                 270         


Thr Tyr Leu Asp Met Asp Tyr Gln Val Gln Ile Gln Glu Glu Phe Glu 
        275                 280                 285             


Glu Ser Ser Glu Ile Leu Leu Lys Glu Phe Leu Lys Pro Glu Lys Phe 
    290                 295                 300                 


Thr Lys Val Cys Glu Ala Leu Glu His Gly His Val Glu Trp Ser Ser 
305                 310                 315                 320 


Arg Gly Pro Pro Asn Lys Arg Phe Tyr Glu Lys Ala Glu Glu Ser Lys 
                325                 330                 335     


Leu Pro Glu Ile Leu Lys Glu Cys Met Lys Leu Phe Arg Ser Glu Ala 
            340                 345                 350         


Leu Phe Leu Leu Leu Ser Asn Phe Thr Gly Leu Lys Leu His Phe Leu 
        355                 360                 365             


Ala Pro Ser Glu Glu Asp Glu Met Asn Asp Lys Lys Glu Ala Glu Thr 
    370                 375                 380                 


Thr Asp Ile Thr Glu Glu Gly Thr Ser His Ser Pro Pro Glu Pro Glu 
385                 390                 395                 400 


Asn Asn Gln Met Ala Ile Ser Asn Asn Ser Gln Gln Ser Asn Glu Gln 
                405                 410                 415     


Thr Asp Pro Glu Pro Glu Glu Asn Glu Thr Lys Lys Glu Ser Ser Val 
            420                 425                 430         


Pro Met Cys Gln Gly Glu Leu Arg His Trp Lys Thr Gly His Tyr Thr 
        435                 440                 445             


Leu Ile His Asp His Ser Lys Ala Glu Phe Ala Leu Asp Leu Ile Leu 
    450                 455                 460                 


Tyr Cys Gly Cys Glu Gly Trp Glu Pro Glu Tyr Gly Gly Phe Thr Ser 
465                 470                 475                 480 


Tyr Ile Ala Lys Gly Glu Asp Glu Glu Leu Leu Thr Val Asn Pro Glu 
                485                 490                 495     


Ser Asn Ser Leu Ala Leu Val Tyr Arg Asp Arg Glu Thr Leu Lys Phe 
            500                 505                 510         


Val Lys His Ile Asn His Arg Ser Leu Glu Gln Lys Lys Thr Phe Pro 
        515                 520                 525             


Asn Arg Thr Gly Phe Trp Asp Phe Ser Phe Ile Tyr Tyr Glu 
    530                 535                 540         


<210>  2
<211>  542
<212>  PRT
<213>  Pongo pygmaeus

<400>  2

Met Asn Gly Lys Arg Pro Ala Glu Pro Gly Pro Ala Arg Val Gly Lys 
1               5                   10                  15      


Lys Arg Lys Lys Glu Val Met Ala Glu Phe Ser Asp Ala Val Thr Glu 
            20                  25                  30          


Glu Thr Leu Lys Lys Gln Val Ala Glu Ala Trp Ser Arg Arg Thr Pro 
        35                  40                  45              


Phe Ser His Glu Val Ile Val Met Asp Met Asp Pro Phe Leu His Cys 
    50                  55                  60                  


Val Ile Pro Asn Phe Ile Gln Ser Gln Asp Phe Leu Glu Gly Leu Gln 
65                  70                  75                  80  


Lys Glu Leu Met Asn Leu Asp Phe His Glu Lys Tyr Asn Asp Leu Tyr 
                85                  90                  95      


Lys Phe Gln Gln Ser Asp Asp Leu Lys Lys Arg Arg Glu Pro His Ile 
            100                 105                 110         


Ser Ala Leu Arg Lys Ile Leu Phe Glu Asp Phe Arg Ser Trp Leu Ser 
        115                 120                 125             


Asp Ile Ser Lys Ile Asp Leu Glu Ser Thr Ile Asp Met Ser Cys Ala 
    130                 135                 140                 


Lys Tyr Glu Phe Thr Asp Ala Leu Leu Cys His Asp Asp Glu Leu Glu 
145                 150                 155                 160 


Gly Arg Arg Ile Ala Phe Ile Leu Tyr Leu Val Pro Pro Trp Asp Arg 
                165                 170                 175     


Ser Leu Gly Gly Thr Leu Asp Leu Tyr Ser Ile Asp Glu His Phe Gln 
            180                 185                 190         


Pro Lys Gln Ile Val Lys Ser Leu Ile Pro Ser Trp Asn Lys Leu Val 
        195                 200                 205             


Phe Phe Glu Val Ser Pro Val Ser Phe His Gln Val Ser Glu Val Leu 
    210                 215                 220                 


Ser Glu Glu Lys Ser Arg Leu Ser Ile Ser Gly Trp Phe His Gly Pro 
225                 230                 235                 240 


Ser Leu Thr Arg Pro Pro Asn His Phe Glu Pro Pro Ile Pro Arg Ser 
                245                 250                 255     


Pro His Ile Pro Gln Asp His Glu Ile Leu Tyr Asp Trp Ile Asn Pro 
            260                 265                 270         


Thr Tyr Leu Asp Met Asp Tyr Gln Val Gln Ile Gln Glu Glu Phe Glu 
        275                 280                 285             


Glu Ser Ser Glu Ile Leu Leu Lys Glu Phe Leu Lys Pro Glu Lys Phe 
    290                 295                 300                 


Met Lys Val Cys Glu Ala Leu Glu His Gly Asp Val Glu Trp Ser Ser 
305                 310                 315                 320 


Arg Gly Pro Pro Asn Lys Arg Phe Tyr Glu Lys Ala Glu Glu Ser Lys 
                325                 330                 335     


Leu Pro Glu Ile Leu Lys Glu Cys Met Lys Leu Phe His Ser Glu Ala 
            340                 345                 350         


Leu Phe Leu Leu Leu Ser Asn Phe Thr Gly Leu Lys Leu His Phe Leu 
        355                 360                 365             


Ala Pro Ser Glu Glu Asp Glu Met Asn Asp Lys Lys Glu Ala Glu Ala 
    370                 375                 380                 


Ala Asp Ile Thr Glu Glu Gly Thr Ser His Ser Pro Pro Glu Pro Glu 
385                 390                 395                 400 


Asn Asn Gln Thr Ala Ile Ser Asn Asn Ser Gln Gln Ser Asn Glu Gln 
                405                 410                 415     


Thr Asp Pro Glu Pro Glu Glu Asn Glu Thr Lys Lys Glu Ser Ser Val 
            420                 425                 430         


Pro Thr Cys Gln Gly Glu Leu Arg Arg Trp Lys Thr Gly His Tyr Thr 
        435                 440                 445             


Leu Ile His Asp His Ser Lys Ala Glu Phe Ala Leu Asp Leu Ile Leu 
    450                 455                 460                 


Tyr Cys Gly Cys Glu Gly Trp Glu Pro Glu Tyr Gly Gly Phe Thr Ser 
465                 470                 475                 480 


Tyr Ile Ala Lys Gly Glu Asp Glu Glu Leu Leu Thr Val Asn Pro Glu 
                485                 490                 495     


Ser Asn Ser Leu Ala Leu Val Tyr Arg Asp Arg Glu Thr Leu Lys Phe 
            500                 505                 510         


Val Lys His Ile Asn His Arg Ser Leu Glu Gln Lys Lys Thr Phe Pro 
        515                 520                 525             


Asn Arg Thr Gly Phe Trp Asp Phe Ser Phe Ile Tyr Tyr Glu 
    530                 535                 540         


<210>  3
<211>  542
<212>  PRT
<213>  Bos taurus

<400>  3

Met Asn Gly Lys Arg Pro Ala Glu Pro Gly Ser Asp Arg Ala Gly Lys 
1               5                   10                  15      


Lys Val Lys Lys Glu Val Met Ala Lys Phe Ser Asp Ala Val Thr Glu 
            20                  25                  30          


Glu Thr Leu Lys Lys Gln Val Ala Glu Ala Trp Ser Arg Arg Thr Pro 
        35                  40                  45              


Phe Arg His Glu Ala Ile Val Met Asp Met Asp Pro Phe Leu His Cys 
    50                  55                  60                  


Val Ile Pro Asn Phe Ile Gln Ser Gln Asn Phe Leu Glu Gly Leu Gln 
65                  70                  75                  80  


Lys Glu Leu Leu Asn Leu Asp Phe His Glu Lys Tyr Asn Asp Leu Tyr 
                85                  90                  95      


Lys Phe Gln Gln Ser Asp Asp Leu Lys Lys Arg Arg Glu Pro His Ile 
            100                 105                 110         


Cys Ala Leu Arg Lys Ile Leu Phe Glu His Phe Arg Ser Trp Ile Ser 
        115                 120                 125             


Asp Ile Ser Lys Ile Asp Leu Glu Ser Thr Ile Asp Met Ser Cys Ala 
    130                 135                 140                 


Lys Tyr Glu Phe Ser Asp Ala Leu Leu Cys His Asp Asp Glu Leu Glu 
145                 150                 155                 160 


Gly Arg Arg Ile Ala Phe Ile Leu Tyr Leu Val Pro Pro Trp Asp Ala 
                165                 170                 175     


Ser Leu Gly Gly Thr Leu Asp Leu Phe Ser Val Asp Glu His Phe Gln 
            180                 185                 190         


Pro Lys Gln Ile Val Lys Ser Leu Ile Pro Ser Trp Asn Thr Leu Val 
        195                 200                 205             


Phe Phe Glu Val Ser Pro Val Ser Phe His Gln Val Ser Glu Val Leu 
    210                 215                 220                 


Ser Glu Glu Lys Ser Arg Leu Ser Ile Ser Gly Trp Phe His Gly Pro 
225                 230                 235                 240 


Ser Leu Thr Arg Pro Pro Thr Tyr Phe Glu Pro Leu Ile Ala Arg Ser 
                245                 250                 255     


Pro His Ile Pro Gln Asp His Glu Ile Leu Tyr Asp Trp Ile Asn Pro 
            260                 265                 270         


Thr Tyr Leu Asp Met Glu Tyr Gln Ala Gln Ile Gln Glu Glu Phe Glu 
        275                 280                 285             


Glu Ser Ser Glu Ile Leu Leu Lys Glu Phe Leu Gln Pro Glu Lys Phe 
    290                 295                 300                 


Ala Glu Val Cys Glu Ala Leu Glu Arg Gly Arg Val Glu Trp Ser Ser 
305                 310                 315                 320 


Arg Gly Pro Pro Asn Lys Arg Phe Tyr Glu Lys Ala Glu Glu Ser Gln 
                325                 330                 335     


Leu Pro Asp Ile Leu Arg Asp Cys Met Ala Leu Phe Arg Ser Glu Ala 
            340                 345                 350         


Met Phe Leu Leu Leu Ser Asn Phe Thr Gly Leu Lys Leu His Phe Leu 
        355                 360                 365             


Ala Pro Ser Glu Asp Glu Pro Glu Asp Lys Lys Glu Arg Asp Ala Val 
    370                 375                 380                 


Ser Ala Ala Glu Asn Thr Glu Glu Gly Thr Ser His Ser Ser Ser Glu 
385                 390                 395                 400 


Pro Glu Asn Ser Trp Ala Ala Thr Ser Asp Ser Ser Leu Gln Ser Glu 
                405                 410                 415     


Gly Pro Thr Asp Pro Glu Glu Asp Glu Ala Lys Lys Glu Ser Ser Val 
            420                 425                 430         


Pro Thr Cys Gln Gly Glu Leu Arg His Trp Lys Thr Gly His Tyr Thr 
        435                 440                 445             


Leu Ile His Asp Asn Ser Lys Thr Glu Phe Ala Leu Asp Leu Leu Leu 
    450                 455                 460                 


Tyr Cys Gly Cys Glu Gly Trp Glu Pro Glu Tyr Gly Gly Phe Thr Ser 
465                 470                 475                 480 


Tyr Ile Ala Lys Gly Glu Asp Glu Glu Leu Leu Thr Val Asn Pro Glu 
                485                 490                 495     


Asn Asn Ser Leu Ala Leu Val Tyr Arg Asp Arg Glu Thr Leu Lys Phe 
            500                 505                 510         


Val Lys His Ile Asn His Arg Ser Leu Glu Gln Lys Lys Ser Phe Pro 
        515                 520                 525             


Asn Arg Thr Gly Phe Trp Asp Phe Ser Phe Val Tyr Tyr Glu 
    530                 535                 540         


<210>  4
<211>  545
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Asn Gly Lys Arg Pro Ala Asp Pro Gly Pro Ala Arg Pro Met Lys 
1               5                   10                  15      


Lys Gly Lys Lys Gln Val Ala Ala Glu Phe Ser Asp Ala Val Thr Glu 
            20                  25                  30          


Glu Ile Leu Arg Lys Gln Val Ala Glu Ala Trp Ser Cys Arg Thr Pro 
        35                  40                  45              


Phe Ser His Glu Ala Ile Ala Leu Asp Met Asp Pro Phe Leu His Cys 
    50                  55                  60                  


Val Ile Pro Asn Phe Ile Gln Ser Gln Asp Phe Leu Glu Gly Leu Gln 
65                  70                  75                  80  


Lys Glu Leu Leu Ser Leu Asp Phe His Glu Lys Tyr Asn Asp Leu Tyr 
                85                  90                  95      


Lys Phe Gln Gln Ser Asp Asp Leu Lys Lys Arg Lys Glu Pro His Ile 
            100                 105                 110         


Ser Ala Leu Arg Thr Leu Met Phe Glu Asp Phe Arg Ala Trp Leu Ser 
        115                 120                 125             


Lys Val Ser Gly Ile Asp Leu Glu Ala Thr Val Asp Met Ser Cys Ala 
    130                 135                 140                 


Lys Tyr Glu Phe Thr Asp Ala Leu Leu Cys His Asp Asp Glu Leu Glu 
145                 150                 155                 160 


Gly Arg Arg Ile Ala Phe Ile Leu Tyr Leu Val Pro Ser Trp Asp Arg 
                165                 170                 175     


Asp Leu Gly Gly Thr Leu Asp Leu Tyr Asp Thr Asp Glu His Leu Gln 
            180                 185                 190         


Pro Lys Gln Ile Val Lys Ser Leu Val Pro Ala Trp Asn Lys Leu Val 
        195                 200                 205             


Phe Phe Glu Val Ser Pro Val Ser Phe His Gln Val Ser Glu Val Leu 
    210                 215                 220                 


Ser Glu Glu Leu Thr Arg Leu Ser Ile Ser Gly Trp Phe His Gly Pro 
225                 230                 235                 240 


Ser Leu Ala Arg Pro Pro Thr Tyr Phe Glu Pro Pro Val Pro Arg Ser 
                245                 250                 255     


Pro His Ile Pro Gln Asp His Glu Ile Leu Tyr Glu Trp Ile Asn Pro 
            260                 265                 270         


Ala Tyr Leu Glu Met Asp Tyr Gln Met Gln Ile Gln Glu Glu Phe Glu 
        275                 280                 285             


Glu Arg Ser Glu Ile Leu Leu Lys Glu Phe Leu Lys Pro Glu Lys Phe 
    290                 295                 300                 


Ala Lys Val Cys Glu Ala Leu Glu Lys Gly Asp Val Glu Trp Lys Ser 
305                 310                 315                 320 


His Gly Pro Pro Asn Lys Arg Phe Tyr Glu Lys Ala Lys Glu Ser Asn 
                325                 330                 335     


Leu Pro Asp Val Leu Lys Glu Cys Met Gly Leu Phe His Ser Glu Ala 
            340                 345                 350         


Met Phe Leu Leu Leu Ser Asn Phe Thr Gly Leu Lys Leu His Phe Leu 
        355                 360                 365             


Ala Pro Ser Glu Asp Asp Glu Thr Glu Asp Lys Gly Glu Gly Glu Thr 
    370                 375                 380                 


Ala Ser Ala Ala Gly Gly Thr Glu Glu Gly Thr Ser Gln Ser Pro Pro 
385                 390                 395                 400 


Gly Pro Glu Asp Asn Gln Ala Ala Val Gly Ser His Ser Gln Glu Asn 
                405                 410                 415     


Gly Glu Gln Ala Asp Pro Glu Pro Gln Glu Asp Glu Ala Lys Lys Glu 
            420                 425                 430         


Ser Ser Val Pro Met Cys Gln Gly Glu Leu Arg Arg Trp Lys Thr Gly 
        435                 440                 445             


His Tyr Thr Leu Val His Asp Asn Ser Lys Thr Glu Phe Ala Leu Asp 
    450                 455                 460                 


Leu Phe Leu Tyr Cys Gly Cys Glu Gly Trp Glu Pro Glu Tyr Gly Gly 
465                 470                 475                 480 


Phe Thr Ser Tyr Ile Ala Lys Gly Glu Asp Glu Glu Leu Leu Ile Val 
                485                 490                 495     


Asn Pro Glu Asn Asn Ala Leu Ala Leu Val Tyr Arg Asp Arg Glu Thr 
            500                 505                 510         


Leu Arg Phe Val Lys His Ile Asn His Arg Ser Leu Glu Gln Arg Asn 
        515                 520                 525             


Thr Phe Pro Asn Arg Ser Gly Phe Trp Asp Phe Ala Phe Met Tyr Tyr 
    530                 535                 540                 


Glu 
545 


<210>  5
<211>  488
<212>  PRT
<213>  Mus musculus

<400>  5

Met Lys Lys Gly Lys Lys Gln Val Ser Ala Glu Phe Ser Asp Ala Val 
1               5                   10                  15      


Thr Glu Glu Ile Leu Arg Lys Gln Val Ala Glu Ala Trp Ser Cys Arg 
            20                  25                  30          


Thr Pro Phe Ser His Glu Ala Ile Ala Leu Asp Met Asp Pro Phe Leu 
        35                  40                  45              


His Cys Val Ile Pro Asn Phe Ile Gln Ser Gln Asp Phe Leu Glu Gly 
    50                  55                  60                  


Leu His Lys Glu Leu Leu Ser Leu Asp Phe His Glu Lys Tyr Asn Asp 
65                  70                  75                  80  


Leu Tyr Lys Phe Gln Gln Ser Asp Asp Leu Lys Asn Arg Lys Glu Pro 
                85                  90                  95      


His Ile Ser Ala Leu Arg Lys Leu Met Phe Glu Asp Phe Arg Ala Trp 
            100                 105                 110         


Leu Ser Lys Val Ser Gly Ile Asp Leu Glu Pro Thr Ile Asp Met Ser 
        115                 120                 125             


Cys Ala Lys Tyr Glu Phe Thr Asp Ala Leu Leu Cys His Asp Asp Glu 
    130                 135                 140                 


Leu Glu Gly Arg Arg Ile Ala Phe Ile Leu Tyr Leu Val Pro Ser Trp 
145                 150                 155                 160 


Asp Arg Asp Leu Gly Gly Thr Leu Asp Leu Tyr Asp Thr Asp Glu His 
                165                 170                 175     


Leu Gln Pro Lys Gln Ile Val Lys Ser Leu Ile Pro Ser Trp Asn Lys 
            180                 185                 190         


Leu Val Phe Phe Glu Val Ser Pro Val Ser Phe His Gln His Glu Ile 
        195                 200                 205             


Leu Tyr Glu Trp Ile Asn Pro Ala Tyr Leu Glu Met Asp Tyr Gln Met 
    210                 215                 220                 


Gln Ile Gln Glu Glu Phe Glu Glu Arg Ser Glu Ile Leu Leu Lys Glu 
225                 230                 235                 240 


Phe Leu Lys Pro Glu Lys Phe Ala Glu Val Cys Glu Ala Leu Glu Lys 
                245                 250                 255     


Gly Asp Val Glu Trp Lys Ser His Gly Pro Pro Asn Lys Arg Phe Tyr 
            260                 265                 270         


Glu Lys Ala Glu Glu Asn Asn Leu Pro Asp Val Leu Lys Glu Cys Met 
        275                 280                 285             


Gly Leu Phe Arg Ser Glu Ala Leu Phe Leu Leu Leu Ser Asn Leu Thr 
    290                 295                 300                 


Gly Leu Lys Leu His Phe Leu Ala Pro Ser Glu Asp Asp Glu Thr Glu 
305                 310                 315                 320 


Glu Lys Gly Glu Gly Glu Thr Ala Ser Ala Ala Ala Gly Thr Glu Glu 
                325                 330                 335     


Gly Thr Ser Arg Arg Pro Ser Gly Pro Glu Asn Asn Gln Val Ala Ala 
            340                 345                 350         


Gly Ser His Ser Gln Glu Asn Gly Glu Gln Ala Asp Pro Glu Ala Gln 
        355                 360                 365             


Glu Glu Glu Ala Lys Lys Glu Ser Ser Val Pro Met Cys Gln Gly Glu 
    370                 375                 380                 


Leu Arg Arg Trp Lys Thr Gly His Tyr Thr Leu Val His Asp Asn Thr 
385                 390                 395                 400 


Lys Thr Glu Phe Ala Leu Asp Leu Phe Leu Tyr Cys Gly Cys Glu Gly 
                405                 410                 415     


Trp Glu Pro Glu Tyr Gly Gly Phe Thr Ser Tyr Ile Ala Lys Gly Glu 
            420                 425                 430         


Asp Glu Glu Leu Leu Ile Val Asn Pro Glu Asn Asn Ser Leu Ala Leu 
        435                 440                 445             


Val Tyr Arg Asp Arg Glu Thr Leu Arg Phe Val Lys His Ile Asn His 
    450                 455                 460                 


Arg Ser Leu Glu Gln Ser Lys Ala Phe Pro Ser Arg Ser Gly Phe Trp 
465                 470                 475                 480 


Asp Phe Ala Phe Ile Tyr Tyr Glu 
                485             


<210>  6
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Lys Cys Arg Gly Leu Arg Thr Ala Arg Lys Leu Arg Ser His 
1               5                   10                  15      


Arg Arg Asp Gln Lys Trp His Asp Lys Gln Tyr Lys Lys Ala His Leu 
            20                  25                  30          


Gly Thr Ala Leu Lys Ala Asn Pro Phe Gly Gly Ala Ser His Ala Lys 
        35                  40                  45              


Gly Ile Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser 
    50                  55                  60                  


Ala Ile Arg Lys Cys Val Arg Val Gln Leu Ile Lys Asn Gly Lys Lys 
65                  70                  75                  80  


Ile Thr Ala Phe Val Pro Asn Asp Gly Cys Leu Asn Phe Ile Glu Glu 
                85                  90                  95      


Asn Asp Glu Val Leu Val Ala Gly Phe Gly Arg Lys Gly His Ala Val 
            100                 105                 110         


Gly Asp Ile Pro Gly Val Arg Phe Lys Val Val Lys Val Ala Asn Val 
        115                 120                 125             


Ser Leu Leu Ala Leu Tyr Lys Gly Lys Lys Glu Arg Pro Arg Ser 
    130                 135                 140             



<210>  7
<211>  292
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal domain of OGFOD1 cloned into pET21d

<400>  7

Met Ala Gln Asp His Glu Ile Leu Tyr Asp Trp Ile Asn Pro Thr Tyr 
1               5                   10                  15      


Leu Asp Met Asp Tyr Gln Val Gln Ile Gln Glu Glu Phe Glu Glu Ser 
            20                  25                  30          


Ser Glu Ile Leu Leu Lys Glu Phe Leu Lys Pro Glu Lys Phe Thr Lys 
        35                  40                  45              


Val Cys Glu Ala Leu Glu His Gly His Val Glu Trp Ser Ser Arg Gly 
    50                  55                  60                  


Pro Pro Asn Lys Arg Phe Tyr Glu Lys Ala Glu Glu Ser Lys Leu Pro 
65                  70                  75                  80  


Glu Ile Leu Lys Glu Cys Met Lys Leu Phe Arg Ser Glu Ala Leu Phe 
                85                  90                  95      


Leu Leu Leu Ser Asn Phe Thr Gly Leu Lys Leu His Phe Leu Ala Pro 
            100                 105                 110         


Ser Glu Glu Asp Glu Met Asn Asp Lys Lys Glu Ala Glu Thr Thr Asp 
        115                 120                 125             


Ile Thr Glu Glu Gly Thr Ser His Ser Pro Pro Glu Pro Glu Asn Asn 
    130                 135                 140                 


Gln Met Ala Ile Ser Asn Asn Ser Gln Gln Ser Asn Glu Gln Thr Asp 
145                 150                 155                 160 


Pro Glu Pro Glu Glu Asn Glu Thr Lys Lys Glu Ser Ser Val Pro Met 
                165                 170                 175     


Cys Gln Gly Glu Leu Arg His Trp Lys Thr Gly His Tyr Thr Leu Ile 
            180                 185                 190         


His Asp His Ser Lys Ala Glu Phe Ala Leu Asp Leu Ile Leu Tyr Cys 
        195                 200                 205             


Gly Cys Glu Gly Trp Glu Pro Glu Tyr Gly Gly Phe Thr Ser Tyr Ile 
    210                 215                 220                 


Ala Lys Gly Glu Asp Glu Glu Leu Leu Thr Val Asn Pro Glu Ser Asn 
225                 230                 235                 240 


Ser Leu Ala Leu Val Tyr Arg Asp Arg Glu Thr Leu Lys Phe Val Lys 
                245                 250                 255     


His Ile Asn His Arg Ser Leu Glu Gln Lys Lys Thr Phe Pro Asn Arg 
            260                 265                 270         


Thr Gly Phe Trp Asp Phe Ser Phe Ile Tyr Tyr Glu Leu Glu His His 
        275                 280                 285             


His His His His 
    290         


<210>  8
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer for OGFOD1_Q261

<400>  8
ataccatggc tcaagatcat gagattt                                           27


<210>  9
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer for OGFOD1_Q261

<400>  9
aaactcgagt tcataataga tgaatgaaa                                         29


<210>  10
<211>  565
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full-length human OGFOD1-H155A mutant clone into pET28

<400>  10

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Met Asn Gly Lys Arg Pro Ala Glu Pro 
            20                  25                  30          


Gly Pro Ala Arg Val Gly Lys Lys Gly Lys Lys Glu Val Met Ala Glu 
        35                  40                  45              


Phe Ser Asp Ala Val Thr Glu Glu Thr Leu Lys Lys Gln Val Ala Glu 
    50                  55                  60                  


Ala Trp Ser Arg Arg Thr Pro Phe Ser His Glu Val Ile Val Met Asp 
65                  70                  75                  80  


Met Asp Pro Phe Leu His Cys Val Ile Pro Asn Phe Ile Gln Ser Gln 
                85                  90                  95      


Asp Phe Leu Glu Gly Leu Gln Lys Glu Leu Met Asn Leu Asp Phe His 
            100                 105                 110         


Glu Lys Tyr Asn Asp Leu Tyr Lys Phe Gln Gln Ser Asp Asp Leu Lys 
        115                 120                 125             


Lys Arg Arg Glu Pro His Ile Ser Thr Leu Arg Lys Ile Leu Phe Glu 
    130                 135                 140                 


Asp Phe Arg Ser Trp Leu Ser Asp Ile Ser Lys Ile Asp Leu Glu Ser 
145                 150                 155                 160 


Thr Ile Asp Met Ser Cys Ala Lys Tyr Glu Phe Thr Asp Ala Leu Leu 
                165                 170                 175     


Cys Ala Asp Asp Glu Leu Glu Gly Arg Arg Ile Ala Phe Ile Leu Tyr 
            180                 185                 190         


Leu Val Pro Pro Trp Asp Arg Ser Met Gly Gly Thr Leu Asp Leu Tyr 
        195                 200                 205             


Ser Ile Asp Glu His Phe Gln Pro Lys Gln Ile Val Lys Ser Leu Ile 
    210                 215                 220                 


Pro Ser Trp Asn Lys Leu Val Phe Phe Glu Val Ser Pro Val Ser Phe 
225                 230                 235                 240 


His Gln Val Ser Glu Val Leu Ser Glu Glu Lys Ser Arg Leu Ser Ile 
                245                 250                 255     


Ser Gly Trp Phe His Gly Pro Ser Leu Thr Arg Pro Pro Asn Tyr Phe 
            260                 265                 270         


Glu Pro Pro Ile Pro Arg Ser Pro His Ile Pro Gln Asp His Glu Ile 
        275                 280                 285             


Leu Tyr Asp Trp Ile Asn Pro Thr Tyr Leu Asp Met Asp Tyr Gln Val 
    290                 295                 300                 


Gln Ile Gln Glu Glu Phe Glu Glu Ser Ser Glu Ile Leu Leu Lys Glu 
305                 310                 315                 320 


Phe Leu Lys Pro Glu Lys Phe Thr Lys Val Cys Glu Ala Leu Glu His 
                325                 330                 335     


Gly His Val Glu Trp Ser Ser Arg Gly Pro Pro Asn Lys Arg Phe Tyr 
            340                 345                 350         


Glu Lys Ala Glu Glu Ser Lys Leu Pro Glu Ile Leu Lys Glu Cys Met 
        355                 360                 365             


Lys Leu Phe Arg Ser Glu Ala Leu Phe Leu Leu Leu Ser Asn Phe Thr 
    370                 375                 380                 


Gly Leu Lys Leu His Phe Leu Ala Pro Ser Glu Glu Asp Glu Met Asn 
385                 390                 395                 400 


Asp Lys Lys Glu Ala Glu Thr Thr Asp Ile Thr Glu Glu Gly Thr Ser 
                405                 410                 415     


His Ser Pro Pro Glu Pro Glu Asn Asn Gln Met Ala Ile Ser Asn Asn 
            420                 425                 430         


Ser Gln Gln Ser Asn Glu Gln Thr Asp Pro Glu Pro Glu Glu Asn Glu 
        435                 440                 445             


Thr Lys Lys Glu Ser Ser Val Pro Met Cys Gln Gly Glu Leu Arg His 
    450                 455                 460                 


Trp Lys Thr Gly His Tyr Thr Leu Ile His Asp His Ser Lys Ala Glu 
465                 470                 475                 480 


Phe Ala Leu Asp Leu Ile Leu Tyr Cys Gly Cys Glu Gly Trp Glu Pro 
                485                 490                 495     


Glu Tyr Gly Gly Phe Thr Ser Tyr Ile Ala Lys Gly Glu Asp Glu Glu 
            500                 505                 510         


Leu Leu Thr Val Asn Pro Glu Ser Asn Ser Leu Ala Leu Val Tyr Arg 
        515                 520                 525             


Asp Arg Glu Thr Leu Lys Phe Val Lys His Ile Asn His Arg Ser Leu 
    530                 535                 540                 


Glu Gln Lys Lys Thr Phe Pro Asn Arg Thr Gly Phe Trp Asp Phe Ser 
545                 550                 555                 560 


Phe Ile Tyr Tyr Glu 
                565 


<210>  11
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer for OGFOD1_H155A

<400>  11
ctgatgccct gctgtgcgcg gatgatgagc tggaagg                                37


<210>  12
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer for OGFOD1-H155A

<400>  12
ccttccagct catcatccgc gcacagcagg gcatcag                                37


<210>  13
<211>  565
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full-length human OGFOD1_D157A mutant cloned into pET28

<400>  13

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Met Asn Gly Lys Arg Pro Ala Glu Pro 
            20                  25                  30          


Gly Pro Ala Arg Val Gly Lys Lys Gly Lys Lys Glu Val Met Ala Glu 
        35                  40                  45              


Phe Ser Asp Ala Val Thr Glu Glu Thr Leu Lys Lys Gln Val Ala Glu 
    50                  55                  60                  


Ala Trp Ser Arg Arg Thr Pro Phe Ser His Glu Val Ile Val Met Asp 
65                  70                  75                  80  


Met Asp Pro Phe Leu His Cys Val Ile Pro Asn Phe Ile Gln Ser Gln 
                85                  90                  95      


Asp Phe Leu Glu Gly Leu Gln Lys Glu Leu Met Asn Leu Asp Phe His 
            100                 105                 110         


Glu Lys Tyr Asn Asp Leu Tyr Lys Phe Gln Gln Ser Asp Asp Leu Lys 
        115                 120                 125             


Lys Arg Arg Glu Pro His Ile Ser Thr Leu Arg Lys Ile Leu Phe Glu 
    130                 135                 140                 


Asp Phe Arg Ser Trp Leu Ser Asp Ile Ser Lys Ile Asp Leu Glu Ser 
145                 150                 155                 160 


Thr Ile Asp Met Ser Cys Ala Lys Tyr Glu Phe Thr Asp Ala Leu Leu 
                165                 170                 175     


Cys Ala Asp Ala Glu Leu Glu Gly Arg Arg Ile Ala Phe Ile Leu Tyr 
            180                 185                 190         


Leu Val Pro Pro Trp Asp Arg Ser Met Gly Gly Thr Leu Asp Leu Tyr 
        195                 200                 205             


Ser Ile Asp Glu His Phe Gln Pro Lys Gln Ile Val Lys Ser Leu Ile 
    210                 215                 220                 


Pro Ser Trp Asn Lys Leu Val Phe Phe Glu Val Ser Pro Val Ser Phe 
225                 230                 235                 240 


His Gln Val Ser Glu Val Leu Ser Glu Glu Lys Ser Arg Leu Ser Ile 
                245                 250                 255     


Ser Gly Trp Phe His Gly Pro Ser Leu Thr Arg Pro Pro Asn Tyr Phe 
            260                 265                 270         


Glu Pro Pro Ile Pro Arg Ser Pro His Ile Pro Gln Asp His Glu Ile 
        275                 280                 285             


Leu Tyr Asp Trp Ile Asn Pro Thr Tyr Leu Asp Met Asp Tyr Gln Val 
    290                 295                 300                 


Gln Ile Gln Glu Glu Phe Glu Glu Ser Ser Glu Ile Leu Leu Lys Glu 
305                 310                 315                 320 


Phe Leu Lys Pro Glu Lys Phe Thr Lys Val Cys Glu Ala Leu Glu His 
                325                 330                 335     


Gly His Val Glu Trp Ser Ser Arg Gly Pro Pro Asn Lys Arg Phe Tyr 
            340                 345                 350         


Glu Lys Ala Glu Glu Ser Lys Leu Pro Glu Ile Leu Lys Glu Cys Met 
        355                 360                 365             


Lys Leu Phe Arg Ser Glu Ala Leu Phe Leu Leu Leu Ser Asn Phe Thr 
    370                 375                 380                 


Gly Leu Lys Leu His Phe Leu Ala Pro Ser Glu Glu Asp Glu Met Asn 
385                 390                 395                 400 


Asp Lys Lys Glu Ala Glu Thr Thr Asp Ile Thr Glu Glu Gly Thr Ser 
                405                 410                 415     


His Ser Pro Pro Glu Pro Glu Asn Asn Gln Met Ala Ile Ser Asn Asn 
            420                 425                 430         


Ser Gln Gln Ser Asn Glu Gln Thr Asp Pro Glu Pro Glu Glu Asn Glu 
        435                 440                 445             


Thr Lys Lys Glu Ser Ser Val Pro Met Cys Gln Gly Glu Leu Arg His 
    450                 455                 460                 


Trp Lys Thr Gly His Tyr Thr Leu Ile His Asp His Ser Lys Ala Glu 
465                 470                 475                 480 


Phe Ala Leu Asp Leu Ile Leu Tyr Cys Gly Cys Glu Gly Trp Glu Pro 
                485                 490                 495     


Glu Tyr Gly Gly Phe Thr Ser Tyr Ile Ala Lys Gly Glu Asp Glu Glu 
            500                 505                 510         


Leu Leu Thr Val Asn Pro Glu Ser Asn Ser Leu Ala Leu Val Tyr Arg 
        515                 520                 525             


Asp Arg Glu Thr Leu Lys Phe Val Lys His Ile Asn His Arg Ser Leu 
    530                 535                 540                 


Glu Gln Lys Lys Thr Phe Pro Asn Arg Thr Gly Phe Trp Asp Phe Ser 
545                 550                 555                 560 


Phe Ile Tyr Tyr Glu 
                565 


<210>  14
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer for OGFOD1_D157A

<400>  14
tgctgtgcca tgatgcggag ctggaagggc gc                                     32


<210>  15
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer for OGFOD1_D157A

<400>  15
gcgcccttcc agctccgcat catggcacag ca                                     32


<210>  16
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile Arg Lys 
1               5                   10                  15      


<210>  18
<211>  20
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  18

Val Val Glu Lys Ile Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Val Leu Glu Lys Leu Gly Ile Glu Ser Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Escherichia coli

<400>  20

Cys Thr Arg Val Tyr Thr Thr Thr Pro Lys Lys Pro Asn Ser Ala Leu 
1               5                   10                  15      


Arg Lys Val Cys 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_K04A

<400>  21

Val Leu Glu Ala Val Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_V05A

<400>  22

Val Leu Glu Lys Ala Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_G06A

<400>  23

Val Leu Glu Lys Val Ala Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_V07A

<400>  24

Val Leu Glu Lys Val Gly Ala Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_E08A

<400>  25

Val Leu Glu Lys Val Gly Val Ala Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_K10A

<400>  26

Val Leu Glu Lys Val Gly Val Glu Ala Ala Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_Q11A

<400>  27

Val Leu Glu Lys Val Gly Val Glu Ala Lys Ala Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_P12A

<400>  28

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Ala Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_P12I

<400>  29

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Ile Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_N13A

<400>  30

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Ala Ser Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_S14A

<400>  31

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ala Ala Ile 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_I16A

<400>  32

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ala 
1               5                   10                  15      


Arg Lys Cys Val 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_R17A

<400>  33

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Ala Lys Cys Val 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_K18A

<400>  34

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Ala Cys Val 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized RPS23_C19A

<400>  35

Val Leu Glu Lys Val Gly Val Glu Ala Lys Gln Pro Asn Ser Ala Ile 
1               5                   10                  15      


Arg Lys Ala Val 
            20  


<210>  36
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Ser Pro Cys Gln Pro Gln Pro Leu Ser Gln Ala Leu Pro Gln 
1               5                   10                  15      


Leu Pro Gly Ser Ser Ser Glu Pro Leu Glu Pro Glu Pro Gly Arg Ala 
            20                  25                  30          


Arg Met Gly Val Glu Ser Tyr Leu Pro Cys Pro Leu Leu Pro Ser Tyr 
        35                  40                  45              


His Cys Pro Gly Val Pro Ser Glu Ala Ser Ala Gly Ser Gly Thr Pro 
    50                  55                  60                  


Arg Ala Thr Ala Thr Ser Thr Thr Ala Ser Pro Leu Arg Asp Gly Phe 
65                  70                  75                  80  


Gly Gly Gln Asp Gly Gly Glu Leu Arg Pro Leu Gln Ser Glu Gly Ala 
                85                  90                  95      


Ala Ala Leu Val Thr Lys Gly Cys Gln Arg Leu Ala Ala Gln Gly Ala 
            100                 105                 110         


Arg Pro Glu Ala Pro Lys Arg Lys Trp Ala Glu Asp Gly Gly Asp Ala 
        115                 120                 125             


Pro Ser Pro Ser Lys Arg Pro Trp Ala Arg Gln Glu Asn Gln Glu Ala 
    130                 135                 140                 


Glu Arg Glu Gly Gly Met Ser Cys Ser Cys Ser Ser Gly Ser Gly Glu 
145                 150                 155                 160 


Ala Ser Ala Gly Leu Met Glu Glu Ala Leu Pro Ser Ala Pro Glu Arg 
                165                 170                 175     


Leu Ala Leu Asp Tyr Ile Val Pro Cys Met Arg Tyr Tyr Gly Ile Cys 
            180                 185                 190         


Val Lys Asp Ser Phe Leu Gly Ala Ala Leu Gly Gly Arg Val Leu Ala 
        195                 200                 205             


Glu Val Glu Ala Leu Lys Arg Gly Gly Arg Leu Arg Asp Gly Gln Leu 
    210                 215                 220                 


Val Ser Gln Arg Ala Ile Pro Pro Arg Ser Ile Arg Gly Asp Gln Ile 
225                 230                 235                 240 


Ala Trp Val Glu Gly His Glu Pro Gly Cys Arg Ser Ile Gly Ala Leu 
                245                 250                 255     


Met Ala His Val Asp Ala Val Ile Arg His Cys Ala Gly Arg Leu Gly 
            260                 265                 270         


Ser Tyr Val Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
        275                 280                 285             


Gly Asn Gly Leu Gly Tyr Val Arg His Val Asp Asn Pro His Gly Asp 
    290                 295                 300                 


Gly Arg Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Gln Asn Trp Asp Val 
305                 310                 315                 320 


Lys Val His Gly Gly Leu Leu Gln Ile Phe Pro Glu Gly Arg Pro Val 
                325                 330                 335     


Val Ala Asn Ile Glu Pro Leu Phe Asp Arg Leu Leu Ile Phe Trp Ser 
            340                 345                 350         


Asp Arg Arg Asn Pro His Glu Val Lys Pro Ala Tyr Ala Thr Arg Tyr 
        355                 360                 365             


Ala Ile Thr Val Trp Tyr Phe Asp Ala Lys Glu Arg Ala Ala Ala Lys 
    370                 375                 380                 


Asp Lys Tyr Gln Leu Ala Ser Gly Gln Lys Gly Val Gln Val Pro Val 
385                 390                 395                 400 


Ser Gln Pro Pro Thr Pro Thr 
                405         


<210>  37
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Asn Asp Ser Gly Gly Pro Gly Gly Pro Ser Pro Ser Glu Arg 
1               5                   10                  15      


Asp Arg Gln Tyr Cys Glu Leu Cys Gly Lys Met Glu Asn Leu Leu Arg 
            20                  25                  30          


Cys Ser Arg Cys Arg Ser Ser Phe Tyr Cys Cys Lys Glu His Gln Arg 
        35                  40                  45              


Gln Asp Trp Lys Lys His Lys Leu Val Cys Gln Gly Ser Glu Gly Ala 
    50                  55                  60                  


Leu Gly His Gly Val Gly Pro His Gln His Ser Gly Pro Ala Pro Pro 
65                  70                  75                  80  


Ala Ala Val Pro Pro Pro Arg Ala Gly Ala Arg Glu Pro Arg Lys Ala 
                85                  90                  95      


Ala Ala Arg Arg Asp Asn Ala Ser Gly Asp Ala Ala Lys Gly Lys Val 
            100                 105                 110         


Lys Ala Lys Pro Pro Ala Asp Pro Ala Ala Ala Ala Ser Pro Cys Arg 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Ser Ala Val Ala Ala Glu Ala Glu Pro 
    130                 135                 140                 


Gly Lys Glu Glu Pro Pro Ala Arg Ser Ser Leu Phe Gln Glu Lys Ala 
145                 150                 155                 160 


Asn Leu Tyr Pro Pro Ser Asn Thr Pro Gly Asp Ala Leu Ser Pro Gly 
                165                 170                 175     


Gly Gly Leu Arg Pro Asn Gly Gln Thr Lys Pro Leu Pro Ala Leu Lys 
            180                 185                 190         


Leu Ala Leu Glu Tyr Ile Val Pro Cys Met Asn Lys His Gly Ile Cys 
        195                 200                 205             


Val Val Asp Asp Phe Leu Gly Lys Glu Thr Gly Gln Gln Ile Gly Asp 
    210                 215                 220                 


Glu Val Arg Ala Leu His Asp Thr Gly Lys Phe Thr Asp Gly Gln Leu 
225                 230                 235                 240 


Val Ser Gln Lys Ser Asp Ser Ser Lys Asp Ile Arg Gly Asp Lys Ile 
                245                 250                 255     


Thr Trp Ile Glu Gly Lys Glu Pro Gly Cys Glu Thr Ile Gly Leu Leu 
            260                 265                 270         


Met Ser Ser Met Asp Asp Leu Ile Arg His Cys Asn Gly Lys Leu Gly 
        275                 280                 285             


Ser Tyr Lys Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
    290                 295                 300                 


Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp 
305                 310                 315                 320 


Gly Arg Cys Val Thr Cys Ile Tyr Tyr Leu Asn Lys Asp Trp Asp Ala 
                325                 330                 335     


Lys Val Ser Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ala Gln 
            340                 345                 350         


Phe Ala Asp Ile Glu Pro Lys Phe Asp Arg Leu Leu Phe Phe Trp Ser 
        355                 360                 365             


Asp Arg Arg Asn Pro His Glu Val Gln Pro Ala Tyr Ala Thr Arg Tyr 
    370                 375                 380                 


Ala Ile Thr Val Trp Tyr Phe Asp Ala Asp Glu Arg Ala Arg Ala Lys 
385                 390                 395                 400 


Val Lys Tyr Leu Thr Gly Glu Lys Gly Val Arg Val Glu Leu Asn Lys 
                405                 410                 415     


Pro Ser Asp Ser Val Gly Lys Asp Val Phe 
            420                 425     


<210>  38
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
            20                  25                  30          


Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
        35                  40                  45              


Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
    50                  55                  60                  


Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
65                  70                  75                  80  


Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                85                  90                  95      


Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
            100                 105                 110         


Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
        115                 120                 125             


Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
    130                 135                 140                 


Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
145                 150                 155                 160 


His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                165                 170                 175     


Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
            180                 185                 190         


Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
        195                 200                 205             


Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
    210                 215                 220                 


Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp 
225                 230                 235                 


