                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
       WEINER, David
       YAN, Jian
       NYAMEKYE, Obeng-Adjei
 
<120>  NUCLEIC ACID MOLECULE ENCODING HEPATITIS B VIRUS CORE PROTEIN

<130>  130694.09500  UPVG0037 X5786

<150>  61/442,162
<151>  2011-02-11

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence M-core


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is a, c, g, or t

<400>  1
nnngacatcg acccctacaa agaattcggc gccaccgtgg aactgctgag cttcctgccc       60

agcgacttct tcccctccgt gcgggacctg ctggataccg ccagcgccct gtacagagag      120

gccctggaaa gccccgagca ctgcagccct caccacacag ccctgcggca ggccatcctg      180

tgctggggcg agctgatgac cctggccacc tgggtcggaa gcaacctgga agatcccgcc      240

agccgggacc tggtggtgtc ctacgtgaac accaacatgg gcctgaagat ccggcagctg      300

ctgtggttcc acatctcctg cctgaccttc ggccgggaaa ccgtgctgga atacctggtg      360

tccttcggcg tgtggatcag aaccccccct gcctacagac cccccaacgc ccctatcctg      420

agcaccctgc ccgagacaac cgtggtccgc agacggggca gaagccccag aagaagaacc      480

cccagcccta gacggcggag atctcagagc cccaggcgga gaagatccca gagccgcgag      540

agccagtgct ga                                                          552


<210>  2
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of M-Core


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Xaa Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala 
65                  70                  75                  80  


Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys 
                85                  90                  95      


Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser 
                165                 170                 175     


Gln Ser Arg Glu Ser Gln Cys 
            180             


<210>  3
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence IgE leader - M-Core

<400>  3
atggactgga cctggattct gttcctggtg gccgctgcca caagggtgca cagcgacatc       60

gacccctaca aagaattcgg cgccaccgtg gaactgctga gcttcctgcc cagcgacttc      120

ttcccctccg tgcgggacct gctggatacc gccagcgccc tgtacagaga ggccctggaa      180

agccccgagc actgcagccc tcaccacaca gccctgcggc aggccatcct gtgctggggc      240

gagctgatga ccctggccac ctgggtcgga agcaacctgg aagatcccgc cagccgggac      300

ctggtggtgt cctacgtgaa caccaacatg ggcctgaaga tccggcagct gctgtggttc      360

cacatctcct gcctgacctt cggccgggaa accgtgctgg aatacctggt gtccttcggc      420

gtgtggatca gaaccccccc tgcctacaga ccccccaacg cccctatcct gagcaccctg      480

cccgagacaa ccgtggtccg cagacggggc agaagcccca gaagaagaac ccccagccct      540

agacggcgga gatctcagag ccccaggcgg agaagatccc agagccgcga gagccagtgc      600

tga                                                                    603


<210>  4
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of IgE leader - M-Core

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu 
            20                  25                  30          


Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu 
        35                  40                  45              


Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His 
    50                  55                  60                  


Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly 
65                  70                  75                  80  


Glu Leu Met Thr Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro 
                85                  90                  95      


Ala Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu 
            100                 105                 110         


Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 
        115                 120                 125             


Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 
    130                 135                 140                 


Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 
145                 150                 155                 160 


Pro Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg 
                165                 170                 175     


Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg 
            180                 185                 190         


Ser Gln Ser Arg Glu Ser Gln Cys 
        195                 200 


<210>  5
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence IgE leader - M-Core + HA Tag

<400>  5
atggactgga cctggattct gttcctggtg gccgctgcca caagggtgca cagcgacatc       60

gacccctaca aagaattcgg cgccaccgtg gaactgctga gcttcctgcc cagcgacttc      120

ttcccctccg tgcgggacct gctggatacc gccagcgccc tgtacagaga ggccctggaa      180

agccccgagc actgcagccc tcaccacaca gccctgcggc aggccatcct gtgctggggc      240

gagctgatga ccctggccac ctgggtcgga agcaacctgg aagatcccgc cagccgggac      300

ctggtggtgt cctacgtgaa caccaacatg ggcctgaaga tccggcagct gctgtggttc      360

cacatctcct gcctgacctt cggccgggaa accgtgctgg aatacctggt gtccttcggc      420

gtgtggatca gaaccccccc tgcctacaga ccccccaacg cccctatcct gagcaccctg      480

cccgagacaa ccgtggtccg cagacggggc agaagcccca gaagaagaac ccccagccct      540

agacggcgga gatctcagag ccccaggcgg agaagatccc agagccgcga gagccagtgc      600

tacccctacg acgtgcccga ctacgcctga                                       630


<210>  6
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of IgE leader - M-Core + HA Tag

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu 
            20                  25                  30          


Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu 
        35                  40                  45              


Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His 
    50                  55                  60                  


Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly 
65                  70                  75                  80  


Glu Leu Met Thr Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro 
                85                  90                  95      


Ala Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu 
            100                 105                 110         


Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 
        115                 120                 125             


Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 
    130                 135                 140                 


Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 
145                 150                 155                 160 


Pro Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg 
                165                 170                 175     


Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg 
            180                 185                 190         


Ser Gln Ser Arg Glu Ser Gln Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
        195                 200                 205             


Ala 
    


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader amino acid sequence

<400>  7

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA Tag amino acid sequence

<400>  8

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


