                         SEQUENCE LISTING

<110>  Trustees of Dartmouth College
       Mulligan-Kehoe, Mary Jo
 
<120>  METHODS FOR INCREASING PLASMIN ACTIVITY AND PROMOTING PLAQUE 
       REGRESSION IN THE TREATMENT OF ATHEROSCLEROSIS

<130>  DC0481WO

<150>  US 61/441,301
<151>  2011-02-10

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  402
<212>  PRT
<213>  Sus scrofa

<400>  1

Met Arg Met Ser Leu Val Phe Ala Cys Leu Ala Met Gly Leu Ala Leu 
1               5                   10                  15      


Thr Phe Ala Glu Gly Ser Ala Ser Ser His His Gln Ser Leu Ala Ala 
            20                  25                  30          


Arg Leu Ala Thr Asp Phe Gly Val Lys Val Phe Arg Gln Val Val Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Ala Gly Asp Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Glu Ala Met Gln Phe Lys Ile Glu Glu Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg Gln Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Ala Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro Tyr Phe Phe Arg Leu Phe Arg Thr Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Met Asp Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Arg His Thr Lys Gly Met Ile Asn Asp Leu Leu Gly 
                165                 170                 175     


Gln Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Glu Lys Ser Thr His 
        195                 200                 205             


His Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Ser Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asn Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Ser Ile Leu Asp Ala Gln Leu Ile Ser Gln Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Thr Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Ser Glu Val Asp Leu Arg Arg Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Pro Asn Gln Ala Asp Phe Ser Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Leu Leu Tyr Met Ser Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Ile Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  2
<211>  402
<212>  PRT
<213>  Bos taurus

<400>  2

Met Arg Met Ser Pro Val Phe Ala Cys Leu Ala Leu Gly Leu Ala Leu 
1               5                   10                  15      


Ile Phe Gly Glu Gly Ser Ala Ser Tyr Gln Pro Gln Ser Ala Ala Ala 
            20                  25                  30          


Ser Leu Ala Thr Asp Phe Gly Val Lys Val Phe Gln Gln Val Val Arg 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Arg Gln Gln 
65                  70                  75                  80  


Ile Gln Glu Ala Met Gln Phe Lys Ile Glu Glu Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Phe His Arg Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Ala Asp Ala Ile Phe Val Gln Arg Asp Leu Glu Leu 
        115                 120                 125             


Val His Gly Phe Met Pro Asn Phe Phe Arg Leu Phe Arg Thr Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Val Asn 
145                 150                 155                 160 


Asp Trp Val Lys Arg His Thr Lys Gly Met Ile Ser Asp Leu Leu Gly 
                165                 170                 175     


Glu Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Met Pro Phe Pro Glu Ser Asn Thr His 
        195                 200                 205             


His Arg Leu Phe His Lys Ser Asp Gly Ser Thr Ile Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly Arg Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asn Thr Leu 
                245                 250                 255     


Ser Met Leu Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Ser Ile Leu Asp Ala Glu Leu Ile Ser Gln Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Thr Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Ile Asp Leu Arg Arg Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Pro Ser Gln Ala Asp Phe Ser Ser Phe Ser Asp Gln Glu 
                325                 330                 335     


Phe Leu Tyr Val Ser Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Leu Ala Ser Ser Ser Thr Ala Leu Val Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  3
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  4
<211>  402
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gln Met Ser Ser Ala Leu Ala Cys Leu Ile Leu Gly Leu Val Leu 
1               5                   10                  15      


Val Ser Gly Lys Gly Phe Thr Leu Pro Leu Arg Glu Ser His Thr Ala 
            20                  25                  30          


His Gln Ala Thr Asp Phe Gly Val Lys Val Phe Gln Gln Val Val Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ser Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Met Thr Thr Ala Gly Lys Thr Arg Arg Gln 
65                  70                  75                  80  


Ile Gln Asp Ala Met Gly Phe Lys Val Asn Glu Lys Gly Thr Ala His 
                85                  90                  95      


Ala Leu Arg Gln Leu Ser Lys Glu Leu Met Gly Pro Trp Asn Lys Asn 
            100                 105                 110         


Glu Ile Ser Thr Ala Asp Ala Ile Phe Val Gln Arg Asp Leu Glu Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Lys Leu Phe Gln Thr Met Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Glu Arg His Thr Lys Gly Met Ile Ser Asp Leu Leu Ala 
                165                 170                 175     


Lys Gly Ala Val Asp Glu Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Ser Gly Gln Trp Lys Thr Pro Phe Leu Glu Ala Ser Thr His 
        195                 200                 205             


Gln Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Ser Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly Leu Glu Tyr Asp Val Val Glu Leu Pro Tyr Gln Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Phe Glu Lys Asp Val His Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Asp Ala Glu Leu Ile Arg Gln Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Ile Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Gly Pro Leu Glu Lys Leu Gly Met Pro Asp 
305                 310                 315                 320 


Met Phe Ser Ala Thr Leu Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Gln Leu Ser Val Ala Gln Ala Leu Gln Lys Val Arg Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Phe Val Ile Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Thr Glu Met Val Ile Asp Arg Ser Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Glu Thr Ile Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  5
<211>  181
<212>  PRT
<213>  Sus scrofa

<400>  5

Met Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Ala Asp Ala Ile Phe 
1               5                   10                  15      


Val Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro Tyr Phe Phe 
            20                  25                  30          


Arg Leu Phe Arg Thr Thr Val Lys Gln Val Asp Phe Ser Glu Met Asp 
        35                  40                  45              


Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Arg His Thr Lys Gly 
    50                  55                  60                  


Met Ile Asn Asp Leu Leu Gly Gln Gly Ala Val Asp Gln Leu Thr Arg 
65                  70                  75                  80  


Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys Thr Pro 
                85                  90                  95      


Phe Pro Glu Lys Ser Thr His His Arg Leu Phe His Lys Ser Asp Gly 
            100                 105                 110         


Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe Asn Tyr 
        115                 120                 125             


Thr Glu Phe Ser Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu Glu Leu 
    130                 135                 140                 


Pro Tyr His Gly Asn Thr Leu Ser Met Phe Ile Ala Ala Pro Tyr Glu 
145                 150                 155                 160 


Lys Glu Val Pro Leu Ser Ala Leu Thr Ser Ile Leu Asp Ala Gln Leu 
                165                 170                 175     


Ile Ser Gln Trp Lys 
            180     


<210>  6
<211>  181
<212>  PRT
<213>  Bos taurus

<400>  6

Met Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Ala Asp Ala Ile Phe 
1               5                   10                  15      


Val Gln Arg Asp Leu Glu Leu Val His Gly Phe Met Pro Asn Phe Phe 
            20                  25                  30          


Arg Leu Phe Arg Thr Thr Val Lys Gln Val Asp Phe Ser Glu Val Glu 
        35                  40                  45              


Arg Ala Arg Phe Ile Val Asn Asp Trp Val Lys Arg His Thr Lys Gly 
    50                  55                  60                  


Met Ile Ser Asp Leu Leu Gly Glu Gly Ala Val Asp Gln Leu Thr Arg 
65                  70                  75                  80  


Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys Met Pro 
                85                  90                  95      


Phe Pro Glu Ser Asn Thr His His Arg Leu Phe His Lys Ser Asp Gly 
            100                 105                 110         


Ser Thr Ile Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe Asn Tyr 
        115                 120                 125             


Thr Glu Phe Thr Thr Pro Asp Gly Arg Tyr Tyr Asp Ile Leu Glu Leu 
    130                 135                 140                 


Pro Tyr His Gly Asn Thr Leu Ser Met Leu Ile Ala Ala Pro Tyr Glu 
145                 150                 155                 160 


Lys Glu Val Pro Leu Ser Ala Leu Thr Ser Ile Leu Asp Ala Glu Leu 
                165                 170                 175     


Ile Ser Gln Trp Lys 
            180     


<210>  7
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Thr Asp Ala Ile Phe 
1               5                   10                  15      


Val Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro His Phe Phe 
            20                  25                  30          


Arg Leu Phe Arg Ser Thr Val Lys Gln Val Asp Phe Ser Glu Val Glu 
        35                  40                  45              


Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr Lys Gly 
    50                  55                  60                  


Met Ile Ser Asn Leu Leu Gly Lys Gly Ala Val Asp Gln Leu Thr Arg 
65                  70                  75                  80  


Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys Thr Pro 
                85                  90                  95      


Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser Asp Gly 
            100                 105                 110         


Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe Asn Tyr 
        115                 120                 125             


Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu Glu Leu 
    130                 135                 140                 


Pro Tyr His Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro Tyr Glu 
145                 150                 155                 160 


Lys Glu Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala Gln Leu 
                165                 170                 175     


Ile Ser His Trp Lys 
            180     


<210>  8
<211>  181
<212>  PRT
<213>  Mus musculus

<400>  8

Met Gly Pro Trp Asn Lys Asn Glu Ile Ser Thr Ala Asp Ala Ile Phe 
1               5                   10                  15      


Val Gln Arg Asp Leu Glu Leu Val Gln Gly Phe Met Pro His Phe Phe 
            20                  25                  30          


Lys Leu Phe Gln Thr Met Val Lys Gln Val Asp Phe Ser Glu Val Glu 
        35                  40                  45              


Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Glu Arg His Thr Lys Gly 
    50                  55                  60                  


Met Ile Ser Asp Leu Leu Ala Lys Gly Ala Val Asp Glu Leu Thr Arg 
65                  70                  75                  80  


Leu Val Leu Val Asn Ala Leu Tyr Phe Ser Gly Gln Trp Lys Thr Pro 
                85                  90                  95      


Phe Leu Glu Ala Ser Thr His Gln Arg Leu Phe His Lys Ser Asp Gly 
            100                 105                 110         


Ser Thr Val Ser Val Pro Met Met Ala Gln Ser Asn Lys Phe Asn Tyr 
        115                 120                 125             


Thr Glu Phe Thr Thr Pro Asp Gly Leu Glu Tyr Asp Val Val Glu Leu 
    130                 135                 140                 


Pro Tyr Gln Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro Phe Glu 
145                 150                 155                 160 


Lys Asp Val His Leu Ser Ala Leu Thr Asn Ile Leu Asp Ala Glu Leu 
                165                 170                 175     


Ile Arg Gln Trp Lys 
            180     


