                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt Heidelberg
 
<120>  B-type plexin antagonists and uses thereof

<130>  UH10427PC

<150>  EP 11 153 784.1
<151>  2011-02-09

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  7143
<212>  DNA
<213>  Homo sapiens

<400>  1
agggccaggt gcgcagggga gaaacaaggc gccttggagt tcaggtgact cccacacggg       60

tcatgctgtt gtctcctgat ccagccggcc ctgccaggtg accatgcctg ctctgggccc      120

agctcttctc caggctctct gggccgggtg ggtcctcacc ctccagcccc ttccaccaac      180

tgcattcact cccaatggca cgtatctgca gcacctggca agggacccca cctcaggcac      240

cctctacctg ggggctacca acttcctgtt ccagctgagc cctgggctgc agctggaggc      300

cacagtgtcc accggccctg tgctagacag cagggactgc ctgccacctg tgatgcctga      360

tgagtgcccc caggcccagc ctaccaacaa cccgaatcag ctgctcctgg tgagcccagg      420

ggccctggtg gtatgcggga gcgtgcacca gggggtctgt gaacagcggc gcctggggca      480

gctcgagcag ctgctgctgc ggccagagcg gcctggggac acacaatatg tggctgccaa      540

tgatcctgcg gtcagcacgg tggggctggt agcccagggc ttggcagggg agcccctcct      600

gtttgtgggg cgaggataca ccagcagggg tgtggggggt ggcattccac ccatcacaac      660

ccgggccctg tggccgcccg acccccaagc tgccttctcc tatgaggaga cagccaagct      720

ggcagtgggc cgcctctccg agtacagcca ccacttcgtg agtgcctttg cacgtggggc      780

cagcgcctac ttcctgttcc tgcggcggga cctgcaggct cagtctagag cttttcgtgc      840

ctatgtatct cgagtgtgtc tccgggacca gcactactac tcctatgtgg agttgcctct      900

ggcctgcgaa ggtggccgct acgggctgat ccaggctgca gctgtggcca cgtccaggga      960

ggtggcgcat ggggaggtgc tctttgcagc tttctcctcg gctgcacccc ccactgtggg     1020

ccggccccca tcggcggctg ctggggcatc tggagcctct gccctctgtg ccttccccct     1080

ggatgaggtg gaccggcttg ctaatcgcac gcgagatgcc tgctacaccc gggagggtcg     1140

tgctgaggat gggaccgagg tggcctacat cgagtatgat gtcaattctg actgtgcaca     1200

gctgccagtg gacaccctgg atgcttatcc ctgtggctca gaccacacgc ccagccccat     1260

ggccagccgg gtcccgctgg aagccacacc aattctggag tggccaggga ttcagctaac     1320

agctgtggca gtcaccatgg aagatggaca caccatcgct ttcctgggtg atagtcaagg     1380

gcagctgcac agggtctact tgggcccagg gagcgatggc cacccatact ccacacagag     1440

catccagcag gggtctgcag tgagcagaga cctcaccttt gatgggacct ttgagcacct     1500

gtatgtcatg acccagagca cacttctgaa ggttcctgtg gcttcctgtg ctcagcacct     1560

ggactgtgca tcttgccttg ctcacaggga cccatactgt gggtggtgcg tgctccttgg     1620

caggtgcagt cgccgttctg agtgctcgag gggccagggc ccagagcagt ggctatggag     1680

cttccagcct gagctgggct gtctgcaagt ggcagccatg agtcctgcca acatcagccg     1740

agaggagacg agggaggttt tcctatcagt gccagacctg ccacccctgt ggccagggga     1800

gtcatattcc tgccactttg gggaacatca gagtcctgcc ctgctgactg gttctggtgt     1860

gatgtgcccc tccccagacc ctagtgaggc cccagtgctg ccgagaggag ccgactacgt     1920

atccgtgagc gtggagctca gatttggcgc tgttgtgatc gccaaaactt ccctctcttt     1980

ctatgactgt gtggcggtca ctgaactccg cccatctgcg cagtgccagg cctgtgtgag     2040

cagccgctgg gggtgtaact ggtgtgtctg gcagcacctg tgcacccaca aggcctcgtg     2100

tgatgctggg cccatggttg caagccatca gagcccgctt gtctccccag accctcctgc     2160

aagaggtgga cccagcccct ccccacccac agcccccaaa gccctggcca cccctgctcc     2220

tgacaccctt cccgtggagc ctggggctcc ctccacagcc acagcttcgg acatctcacc     2280

tggggctagt ccttccctgc tcagcccctg ggggccatgg gcaggttctg gctccatatc     2340

ttcccctggc tccacagggt cgcctctcca tgaggagccc tcccctccca gcccccaaaa     2400

tggacctgga accgctgtcc ctgcccccac tgacttcaga ccctcagcca cacctgagga     2460

cctcttggcc tccccgctgt caccgtcaga ggtagcagca gtgccccctg cagaccctgg     2520

ccccgaggct cttcatccca cagtgcccct ggacctgccc cctgccactg ttcctgccac     2580

cactttccca ggggccatgg gctccgtgaa gcccgccctg gactggctca cgagagaagg     2640

cggcgagctg cccgaggcgg acgagtggac ggggggtgac gcacccgcct tctccacttc     2700

caccctcctc tcaggtgatg gagactcagc agagcttgag ggccctcccg cccccctcat     2760

cctcccgtcc agcctcgact accagtatga cacccccggg ctctgggagc tggaagaggc     2820

gaccttgggg gcaagctcct gcccctgtgt ggagagcgtt cagggctcca cgttgatgcc     2880

ggtccatgtg gagcgggaaa tccggctgct aggcaggaac ctgcaccttt tccaggatgg     2940

cccaggagac aatgagtgtg tgatggagct ggagggcctc gaggtggtgg ttgaggcccg     3000

ggtcgagtgt gagccacctc cagataccca gtgccatgtc acctgccagc agcaccagct     3060

cagctatgag gctctgcagc cggagctccg tgtggggctg tttctgcgtc gggccggccg     3120

tctgcgtgtg gacagtgctg aggggctgca tgtggtactg tatgactgtt ccgtgggaca     3180

tggagactgc agccgctgcc aaactgccat gccccagtat ggctgtgtgt ggtgtgaggg     3240

ggagcgtcca cgttgtgtga cccgggaggc ctgtggtgag gctgaggctg tggccaccca     3300

gtgcccagcg cccctcatcc actcggtgga gccactgact gggcctgtag acggaggcac     3360

ccgtgtcacc atcaggggct ccaacctggg ccagcatgtg caggatgtgc tgggcatggt     3420

cacggtggct ggagtgccct gtgctgtgga tgcccaggag tacgaggtct ccagcagcct     3480

cgtgtgcatc accggggcca gtggggagga ggtggccggc gccacagcgg tggaggtgcc     3540

gggaagagga cgtggtgtct cagaacacga ctttgcctac caggatccga aggtccattc     3600

catcttcccg gcccgcggcc ccagagctgg gggcacccgt ctcaccctga atggctccaa     3660

gctcctgact gggcggctgg aggacatccg agtggtggtt ggagaccagc cttgtcactt     3720

gctgccggag cagcagtcag aacaactgcg gtgtgagacc agcccacgcc ccacgcctgc     3780

cacgctccct gtggctgtgt ggtttggggc cacggagcgg aggcttcaac gcggacagtt     3840

caagtatacc ttggacccca acatcacctc tgctggcccc accaagagct tcctcagtgg     3900

aggacgtgag atatgcgtcc gtggccagaa tctggacgtg gtacagacgc caagaatccg     3960

ggtgaccgtg gtctcgagaa tgctgcagcc cagccagggg cttggacgga ggcgtcgcgt     4020

ggtcccggag acggcatgtt cccttggacc ctcctgcagt agccagcaat ttgaggagcc     4080

gtgccatgtc aactcctccc agctcatcac gtgccgcaca cctgccctcc caggcctgcc     4140

tgaggacccc tgggtccggg tggaatttat ccttgacaac ctggtctttg actttgcaac     4200

actgaacccc acacctttct cctatgaggc cgaccccacc ctgcagccac tcaaccctga     4260

ggaccccacc atgccattcc ggcacaagcc tgggagtgtg ttctccgtgg agggggagaa     4320

cctggacctt gcaatgtcca aggaggaggt ggtggctatg ataggggatg gcccctgtgt     4380

ggtgaagacg ctgacgcggc accacctgta ctgcgagccc cccgtggagc agcccctgcc     4440

acggcaccat gccctccgag aggcacctga ctctttgcct gagttcacgg tgcagatggg     4500

gaacttgcgc ttctccctgg gtcacgtgca gtatgacggc gagagccctg gggcttttcc     4560

tgtggcagcc caggtgggct tgggggtggg cacctctctt ctggctctgg gtgtcatcat     4620

cattgtcctc atgtacagga ggaagagcaa gcaggccctg agggactata agaaggttca     4680

gatccagctg gagaatctgg agagcagtgt gcgggaccgc tgcaagaagg aattcacaga     4740

cctcatgact gagatgaccg atctcaccag tgacctcctg ggcagcggca tccccttcct     4800

cgactacaag gtgtatgcgg agaggatctt cttccctggg caccgcgagt cgcccttgca     4860

ccgggacctg ggtgtgcctg agagcagacg gcccactgtg gagcaagggc tggggcagct     4920

ctctaacctg ctcaacagca agctcttcct caccaagttc atccacacgc tggagagcca     4980

gcgcaccttt tcagctcggg accgtgccta cgtggcatct ctgctcaccg tggcactgca     5040

tgggaagctt gagtatttca ctgacatcct ccgcactctg ctcagtgacc tggttgccca     5100

gtatgtggcc aagaacccca agctgatgct gcgcaggaca gagactgtgg tggagaagct     5160

gctcaccaac tggatgtcca tctgtctgta taccttcgtg agggactccg taggggagcc     5220

tctgtacatg ctctttcgag ggattaagca ccaagtggat aaggggccag tggacagtgt     5280

gacaggcaag gccaaataca ccttgaacga caaccgcctg ctcagagagg atgtggagta     5340

ccgtcccctg accttgaatg cactattggc tgtggggcct ggggcaggag aggcccaggg     5400

cgtgcccgtg aaggtcctag actgtgacac catctcccag gcaaaggaga agatgctgga     5460

ccagctttat aaaggagtgc ctctcaccca gcggccagac cctcgcaccc ttgatgttga     5520

gtggcggtct ggggtggccg ggcacctcat tctttctgac gaggatgtca cttctgaggt     5580

ccagggtctg tggaggcgcc tgaacacact gcagcattac aaggtcccag atggagcaac     5640

tgtggccctc gtcccctgcc tcaccaagca tgtgctccgg gaaaaccagg attatgtccc     5700

tggagagcgg accccaatgc tggaggatgt agatgagggg ggcatccggc cctggcacct     5760

ggtgaagcca agtgatgagc cggagccgcc caggcctcgg aggggcagcc ttcggggcgg     5820

ggagcgtgag cgcgccaagg ccatccctga gatctacctg acccgcctgc tgtccatgaa     5880

gggcaccctg cagaagttcg tggatgacct gttccaggtg attctcagca ccagccgccc     5940

cgtgccgctc gctgtgaagt acttctttga cctgctggat gagcaggccc agcagcatgg     6000

catctccgac caggacacca tccacatctg gaagaccaac agcttgcctc tgaggttctg     6060

gatcaatata ataaaaaacc cgcagtttgt gttcgacgtg caaacatctg ataacatgga     6120

tgcggtgctc cttgtcattg cacagacctt catggacgcc tgcaccctgg ccgaccacaa     6180

gctgggccgg gactccccga tcaacaaact tctgtatgca cgggacattc cccggtacaa     6240

gcggatggtg gaaaggtact atgcagacat cagacagact gtcccagcca gcgaccaaga     6300

gatgaactct gtcctggctg aactgtcctg gaactactcc ggagacctcg gggcgcgagt     6360

ggccctgcat gaactctaca agtacatcaa caagtactat gaccagatca tcactgccct     6420

ggaggaggat ggcacggccc agaagatgca gctgggctat cggctccagc agattgcagc     6480

tgctgtggaa aacaaggtca cagatctata ggaacccagg agccacggcc tgctgttgct     6540

tcagcctggc ctgggcagcc ctggaagctc ggaggagagg ccaccttctt aggtgcctgt     6600

agtgactgac aagcagagtt agtggaaggt gactcccagt ctcctggtgg ctctggcctc     6660

ggccctgctg gatccacctc ctagacccgg ggcctcaagg ctcatggggt agtacccagc     6720

ctgctccccg agtccagcga ccctgtgaca ccggtctgca gggagttggg gactaagggc     6780

ttccagagag tggctggaag agactccagg cccctgggga gactgtactg ttcctgaaca     6840

ctggccttgg ccacactggg attcggagag gaaggaggag agccccatgc ttcctgtctg     6900

cctcctccac catccctgac ctcagttgag ctgcctctgg ccttgttgct gctgccacat     6960

cctaggtcta agagttgaac gcctctccta ggccactaca aactgacccc tcagcagggc     7020

tggctgccac agggctgccc tgcctcatag gtagccatgg tgagggctat ctgctgcagg     7080

ggggtcttgg ggagagtggt gactccattg acccagcttt tcattaaagg ataacacact     7140

gca                                                                   7143


<210>  2
<211>  2135
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ala Leu Gly Pro Ala Leu Leu Gln Ala Leu Trp Ala Gly Trp 
1               5                   10                  15      


Val Leu Thr Leu Gln Pro Leu Pro Pro Thr Ala Phe Thr Pro Asn Gly 
            20                  25                  30          


Thr Tyr Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr 
        35                  40                  45              


Leu Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  


Glu Ala Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  


Pro Pro Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      


Pro Asn Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly 
            100                 105                 110         


Ser Val His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu 
        115                 120                 125             


Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 


Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 


Ala Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     


Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro 
            180                 185                 190         


Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             


Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg 
    210                 215                 220                 


Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln 
225                 230                 235                 240 


Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln 
                245                 250                 255     


His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg 
            260                 265                 270         


Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala 
        275                 280                 285             


His Gly Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Thr 
    290                 295                 300                 


Val Gly Arg Pro Pro Ser Ala Ala Ala Gly Ala Ser Gly Ala Ser Ala 
305                 310                 315                 320 


Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Arg Leu Ala Asn Arg Thr 
                325                 330                 335     


Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asp Gly Thr Glu 
            340                 345                 350         


Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             


Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 


Pro Met Ala Ser Arg Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Trp 
385                 390                 395                 400 


Pro Gly Ile Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     


Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         


Leu Gly Pro Gly Ser Asp Gly His Pro Tyr Ser Thr Gln Ser Ile Gln 
        435                 440                 445             


Gln Gly Ser Ala Val Ser Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 


His Leu Tyr Val Met Thr Gln Ser Thr Leu Leu Lys Val Pro Val Ala 
465                 470                 475                 480 


Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     


Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         


Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             


Pro Glu Leu Gly Cys Leu Gln Val Ala Ala Met Ser Pro Ala Asn Ile 
    530                 535                 540                 


Ser Arg Glu Glu Thr Arg Glu Val Phe Leu Ser Val Pro Asp Leu Pro 
545                 550                 555                 560 


Pro Leu Trp Pro Gly Glu Ser Tyr Ser Cys His Phe Gly Glu His Gln 
                565                 570                 575     


Ser Pro Ala Leu Leu Thr Gly Ser Gly Val Met Cys Pro Ser Pro Asp 
            580                 585                 590         


Pro Ser Glu Ala Pro Val Leu Pro Arg Gly Ala Asp Tyr Val Ser Val 
        595                 600                 605             


Ser Val Glu Leu Arg Phe Gly Ala Val Val Ile Ala Lys Thr Ser Leu 
    610                 615                 620                 


Ser Phe Tyr Asp Cys Val Ala Val Thr Glu Leu Arg Pro Ser Ala Gln 
625                 630                 635                 640 


Cys Gln Ala Cys Val Ser Ser Arg Trp Gly Cys Asn Trp Cys Val Trp 
                645                 650                 655     


Gln His Leu Cys Thr His Lys Ala Ser Cys Asp Ala Gly Pro Met Val 
            660                 665                 670         


Ala Ser His Gln Ser Pro Leu Val Ser Pro Asp Pro Pro Ala Arg Gly 
        675                 680                 685             


Gly Pro Ser Pro Ser Pro Pro Thr Ala Pro Lys Ala Leu Ala Thr Pro 
    690                 695                 700                 


Ala Pro Asp Thr Leu Pro Val Glu Pro Gly Ala Pro Ser Thr Ala Thr 
705                 710                 715                 720 


Ala Ser Asp Ile Ser Pro Gly Ala Ser Pro Ser Leu Leu Ser Pro Trp 
                725                 730                 735     


Gly Pro Trp Ala Gly Ser Gly Ser Ile Ser Ser Pro Gly Ser Thr Gly 
            740                 745                 750         


Ser Pro Leu His Glu Glu Pro Ser Pro Pro Ser Pro Gln Asn Gly Pro 
        755                 760                 765             


Gly Thr Ala Val Pro Ala Pro Thr Asp Phe Arg Pro Ser Ala Thr Pro 
    770                 775                 780                 


Glu Asp Leu Leu Ala Ser Pro Leu Ser Pro Ser Glu Val Ala Ala Val 
785                 790                 795                 800 


Pro Pro Ala Asp Pro Gly Pro Glu Ala Leu His Pro Thr Val Pro Leu 
                805                 810                 815     


Asp Leu Pro Pro Ala Thr Val Pro Ala Thr Thr Phe Pro Gly Ala Met 
            820                 825                 830         


Gly Ser Val Lys Pro Ala Leu Asp Trp Leu Thr Arg Glu Gly Gly Glu 
        835                 840                 845             


Leu Pro Glu Ala Asp Glu Trp Thr Gly Gly Asp Ala Pro Ala Phe Ser 
    850                 855                 860                 


Thr Ser Thr Leu Leu Ser Gly Asp Gly Asp Ser Ala Glu Leu Glu Gly 
865                 870                 875                 880 


Pro Pro Ala Pro Leu Ile Leu Pro Ser Ser Leu Asp Tyr Gln Tyr Asp 
                885                 890                 895     


Thr Pro Gly Leu Trp Glu Leu Glu Glu Ala Thr Leu Gly Ala Ser Ser 
            900                 905                 910         


Cys Pro Cys Val Glu Ser Val Gln Gly Ser Thr Leu Met Pro Val His 
        915                 920                 925             


Val Glu Arg Glu Ile Arg Leu Leu Gly Arg Asn Leu His Leu Phe Gln 
    930                 935                 940                 


Asp Gly Pro Gly Asp Asn Glu Cys Val Met Glu Leu Glu Gly Leu Glu 
945                 950                 955                 960 


Val Val Val Glu Ala Arg Val Glu Cys Glu Pro Pro Pro Asp Thr Gln 
                965                 970                 975     


Cys His Val Thr Cys Gln Gln His Gln Leu Ser Tyr Glu Ala Leu Gln 
            980                 985                 990         


Pro Glu Leu Arg Val Gly Leu Phe  Leu Arg Arg Ala Gly  Arg Leu Arg 
        995                 1000                 1005             


Val Asp  Ser Ala Glu Gly Leu  His Val Val Leu Tyr  Asp Cys Ser 
    1010                 1015                 1020             


Val Gly  His Gly Asp Cys Ser  Arg Cys Gln Thr Ala  Met Pro Gln 
    1025                 1030                 1035             


Tyr Gly  Cys Val Trp Cys Glu  Gly Glu Arg Pro Arg  Cys Val Thr 
    1040                 1045                 1050             


Arg Glu  Ala Cys Gly Glu Ala  Glu Ala Val Ala Thr  Gln Cys Pro 
    1055                 1060                 1065             


Ala Pro  Leu Ile His Ser Val  Glu Pro Leu Thr Gly  Pro Val Asp 
    1070                 1075                 1080             


Gly Gly  Thr Arg Val Thr Ile  Arg Gly Ser Asn Leu  Gly Gln His 
    1085                 1090                 1095             


Val Gln  Asp Val Leu Gly Met  Val Thr Val Ala Gly  Val Pro Cys 
    1100                 1105                 1110             


Ala Val  Asp Ala Gln Glu Tyr  Glu Val Ser Ser Ser  Leu Val Cys 
    1115                 1120                 1125             


Ile Thr  Gly Ala Ser Gly Glu  Glu Val Ala Gly Ala  Thr Ala Val 
    1130                 1135                 1140             


Glu Val  Pro Gly Arg Gly Arg  Gly Val Ser Glu His  Asp Phe Ala 
    1145                 1150                 1155             


Tyr Gln  Asp Pro Lys Val His  Ser Ile Phe Pro Ala  Arg Gly Pro 
    1160                 1165                 1170             


Arg Ala  Gly Gly Thr Arg Leu  Thr Leu Asn Gly Ser  Lys Leu Leu 
    1175                 1180                 1185             


Thr Gly  Arg Leu Glu Asp Ile  Arg Val Val Val Gly  Asp Gln Pro 
    1190                 1195                 1200             


Cys His  Leu Leu Pro Glu Gln  Gln Ser Glu Gln Leu  Arg Cys Glu 
    1205                 1210                 1215             


Thr Ser  Pro Arg Pro Thr Pro  Ala Thr Leu Pro Val  Ala Val Trp 
    1220                 1225                 1230             


Phe Gly  Ala Thr Glu Arg Arg  Leu Gln Arg Gly Gln  Phe Lys Tyr 
    1235                 1240                 1245             


Thr Leu  Asp Pro Asn Ile Thr  Ser Ala Gly Pro Thr  Lys Ser Phe 
    1250                 1255                 1260             


Leu Ser  Gly Gly Arg Glu Ile  Cys Val Arg Gly Gln  Asn Leu Asp 
    1265                 1270                 1275             


Val Val  Gln Thr Pro Arg Ile  Arg Val Thr Val Val  Ser Arg Met 
    1280                 1285                 1290             


Leu Gln  Pro Ser Gln Gly Leu  Gly Arg Arg Arg Arg  Val Val Pro 
    1295                 1300                 1305             


Glu Thr  Ala Cys Ser Leu Gly  Pro Ser Cys Ser Ser  Gln Gln Phe 
    1310                 1315                 1320             


Glu Glu  Pro Cys His Val Asn  Ser Ser Gln Leu Ile  Thr Cys Arg 
    1325                 1330                 1335             


Thr Pro  Ala Leu Pro Gly Leu  Pro Glu Asp Pro Trp  Val Arg Val 
    1340                 1345                 1350             


Glu Phe  Ile Leu Asp Asn Leu  Val Phe Asp Phe Ala  Thr Leu Asn 
    1355                 1360                 1365             


Pro Thr  Pro Phe Ser Tyr Glu  Ala Asp Pro Thr Leu  Gln Pro Leu 
    1370                 1375                 1380             


Asn Pro  Glu Asp Pro Thr Met  Pro Phe Arg His Lys  Pro Gly Ser 
    1385                 1390                 1395             


Val Phe  Ser Val Glu Gly Glu  Asn Leu Asp Leu Ala  Met Ser Lys 
    1400                 1405                 1410             


Glu Glu  Val Val Ala Met Ile  Gly Asp Gly Pro Cys  Val Val Lys 
    1415                 1420                 1425             


Thr Leu  Thr Arg His His Leu  Tyr Cys Glu Pro Pro  Val Glu Gln 
    1430                 1435                 1440             


Pro Leu  Pro Arg His His Ala  Leu Arg Glu Ala Pro  Asp Ser Leu 
    1445                 1450                 1455             


Pro Glu  Phe Thr Val Gln Met  Gly Asn Leu Arg Phe  Ser Leu Gly 
    1460                 1465                 1470             


His Val  Gln Tyr Asp Gly Glu  Ser Pro Gly Ala Phe  Pro Val Ala 
    1475                 1480                 1485             


Ala Gln  Val Gly Leu Gly Val  Gly Thr Ser Leu Leu  Ala Leu Gly 
    1490                 1495                 1500             


Val Ile  Ile Ile Val Leu Met  Tyr Arg Arg Lys Ser  Lys Gln Ala 
    1505                 1510                 1515             


Leu Arg  Asp Tyr Lys Lys Val  Gln Ile Gln Leu Glu  Asn Leu Glu 
    1520                 1525                 1530             


Ser Ser  Val Arg Asp Arg Cys  Lys Lys Glu Phe Thr  Asp Leu Met 
    1535                 1540                 1545             


Thr Glu  Met Thr Asp Leu Thr  Ser Asp Leu Leu Gly  Ser Gly Ile 
    1550                 1555                 1560             


Pro Phe  Leu Asp Tyr Lys Val  Tyr Ala Glu Arg Ile  Phe Phe Pro 
    1565                 1570                 1575             


Gly His  Arg Glu Ser Pro Leu  His Arg Asp Leu Gly  Val Pro Glu 
    1580                 1585                 1590             


Ser Arg  Arg Pro Thr Val Glu  Gln Gly Leu Gly Gln  Leu Ser Asn 
    1595                 1600                 1605             


Leu Leu  Asn Ser Lys Leu Phe  Leu Thr Lys Phe Ile  His Thr Leu 
    1610                 1615                 1620             


Glu Ser  Gln Arg Thr Phe Ser  Ala Arg Asp Arg Ala  Tyr Val Ala 
    1625                 1630                 1635             


Ser Leu  Leu Thr Val Ala Leu  His Gly Lys Leu Glu  Tyr Phe Thr 
    1640                 1645                 1650             


Asp Ile  Leu Arg Thr Leu Leu  Ser Asp Leu Val Ala  Gln Tyr Val 
    1655                 1660                 1665             


Ala Lys  Asn Pro Lys Leu Met  Leu Arg Arg Thr Glu  Thr Val Val 
    1670                 1675                 1680             


Glu Lys  Leu Leu Thr Asn Trp  Met Ser Ile Cys Leu  Tyr Thr Phe 
    1685                 1690                 1695             


Val Arg  Asp Ser Val Gly Glu  Pro Leu Tyr Met Leu  Phe Arg Gly 
    1700                 1705                 1710             


Ile Lys  His Gln Val Asp Lys  Gly Pro Val Asp Ser  Val Thr Gly 
    1715                 1720                 1725             


Lys Ala  Lys Tyr Thr Leu Asn  Asp Asn Arg Leu Leu  Arg Glu Asp 
    1730                 1735                 1740             


Val Glu  Tyr Arg Pro Leu Thr  Leu Asn Ala Leu Leu  Ala Val Gly 
    1745                 1750                 1755             


Pro Gly  Ala Gly Glu Ala Gln  Gly Val Pro Val Lys  Val Leu Asp 
    1760                 1765                 1770             


Cys Asp  Thr Ile Ser Gln Ala  Lys Glu Lys Met Leu  Asp Gln Leu 
    1775                 1780                 1785             


Tyr Lys  Gly Val Pro Leu Thr  Gln Arg Pro Asp Pro  Arg Thr Leu 
    1790                 1795                 1800             


Asp Val  Glu Trp Arg Ser Gly  Val Ala Gly His Leu  Ile Leu Ser 
    1805                 1810                 1815             


Asp Glu  Asp Val Thr Ser Glu  Val Gln Gly Leu Trp  Arg Arg Leu 
    1820                 1825                 1830             


Asn Thr  Leu Gln His Tyr Lys  Val Pro Asp Gly Ala  Thr Val Ala 
    1835                 1840                 1845             


Leu Val  Pro Cys Leu Thr Lys  His Val Leu Arg Glu  Asn Gln Asp 
    1850                 1855                 1860             


Tyr Val  Pro Gly Glu Arg Thr  Pro Met Leu Glu Asp  Val Asp Glu 
    1865                 1870                 1875             


Gly Gly  Ile Arg Pro Trp His  Leu Val Lys Pro Ser  Asp Glu Pro 
    1880                 1885                 1890             


Glu Pro  Pro Arg Pro Arg Arg  Gly Ser Leu Arg Gly  Gly Glu Arg 
    1895                 1900                 1905             


Glu Arg  Ala Lys Ala Ile Pro  Glu Ile Tyr Leu Thr  Arg Leu Leu 
    1910                 1915                 1920             


Ser Met  Lys Gly Thr Leu Gln  Lys Phe Val Asp Asp  Leu Phe Gln 
    1925                 1930                 1935             


Val Ile  Leu Ser Thr Ser Arg  Pro Val Pro Leu Ala  Val Lys Tyr 
    1940                 1945                 1950             


Phe Phe  Asp Leu Leu Asp Glu  Gln Ala Gln Gln His  Gly Ile Ser 
    1955                 1960                 1965             


Asp Gln  Asp Thr Ile His Ile  Trp Lys Thr Asn Ser  Leu Pro Leu 
    1970                 1975                 1980             


Arg Phe  Trp Ile Asn Ile Ile  Lys Asn Pro Gln Phe  Val Phe Asp 
    1985                 1990                 1995             


Val Gln  Thr Ser Asp Asn Met  Asp Ala Val Leu Leu  Val Ile Ala 
    2000                 2005                 2010             


Gln Thr  Phe Met Asp Ala Cys  Thr Leu Ala Asp His  Lys Leu Gly 
    2015                 2020                 2025             


Arg Asp  Ser Pro Ile Asn Lys  Leu Leu Tyr Ala Arg  Asp Ile Pro 
    2030                 2035                 2040             


Arg Tyr  Lys Arg Met Val Glu  Arg Tyr Tyr Ala Asp  Ile Arg Gln 
    2045                 2050                 2055             


Thr Val  Pro Ala Ser Asp Gln  Glu Met Asn Ser Val  Leu Ala Glu 
    2060                 2065                 2070             


Leu Ser  Trp Asn Tyr Ser Gly  Asp Leu Gly Ala Arg  Val Ala Leu 
    2075                 2080                 2085             


His Glu  Leu Tyr Lys Tyr Ile  Asn Lys Tyr Tyr Asp  Gln Ile Ile 
    2090                 2095                 2100             


Thr Ala  Leu Glu Glu Asp Gly  Thr Ala Gln Lys Met  Gln Leu Gly 
    2105                 2110                 2115             


Tyr Arg  Leu Gln Gln Ile Ala  Ala Ala Val Glu Asn  Lys Val Thr 
    2120                 2125                 2130             


Asp Leu  
    2135 


<210>  3
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  siRNA human plexin B1

<400>  3
accacgguca cccggauuc                                                    19


<210>  4
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer 5plexin

<400>  4
cagccaccac ttcgtgagtg cc                                                22


<210>  5
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  primer 3 plexin

<400>  5
ggtgactgcc acagctgtta gctg                                              24


<210>  6
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer 5' plexin-B1

<400>  6
cagccaccac ttcgtgagtg cc                                                22


<210>  7
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer 5' beta-actin

<400>  7
atggatgatg atatcgccgc g                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer 3' beta-actin

<400>  8
gaagcatttg cggtggacga t                                                 21


<210>  9
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer 5' plexin-B1

<400>  9
ggtggaaagg tactatgcag acatcag                                           27


<210>  10
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer 3' plexin-B1

<400>  10
cctcctccag ggcagtgatg atc                                               23


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer 5' beta-actin

<400>  11
ggtgtgatgg tgggaatggg tcag                                              24


<210>  12
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer 3' beta-actin

<400>  12
gaggaagagg atgcggcagt gg                                                22


<210>  13
<211>  82
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

His Leu Xaa Xaa Pro Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser 
1               5                   10                  15      


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Arg Asn Tyr 
            20                  25                  30          


Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr 
        35                  40                  45              


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
    50                  55                  60                  


Asn Ser Met Gly Pro Trp Asp Leu Arg Lys Leu Ser Leu Asp Tyr Ala 
65                  70                  75                  80  


Glu Lys 
        


<210>  14
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  14

Asn Glu Asn Val Ala Gly Ser Phe Leu Glu Leu Ala Val Trp His Gln 
1               5                   10                  15      


<210>  15
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  15

Lys Asp Gln Val Gln Leu Val Gln Ser Ser Thr Tyr Ser Val Pro Thr 
1               5                   10                  15      


Ala Pro Arg Leu Leu Leu His Pro Met Ala Ser Leu Gly Leu Ile Ala 
            20                  25                  30          


Leu Ala Phe Gly Ser Asp Glu Asp Lys Asn Gly Trp Ile Leu 
        35                  40                  45      


<210>  16
<211>  55
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Asn Gln Phe Trp Pro Ser Gly Ser Ser Arg Val Gln Leu Cys Met Ala 
1               5                   10                  15      


Gln Glu Gly Lys Arg Ser Pro Thr Val Thr Ser Arg Gln Leu Gly Thr 
            20                  25                  30          


Gly Trp Gly Phe Pro Met Thr Val Ala Ala Pro Ser Val Ile Leu Arg 
        35                  40                  45              


Lys Thr Xaa Ala Ser Glu Xaa 
    50                  55  


<210>  17
<211>  74
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Thr Pro Tyr Pro Ser Gly Val Ile Arg Leu Thr Ile Gly Arg Ala Xaa 
1               5                   10                  15      


Xaa Thr Ile Phe Arg Met Ala Arg Val Phe Gln Gln Asp Glu Val Gln 
            20                  25                  30          


Leu Val Gln Trp Pro Ser Phe Tyr Leu Gly Val Arg Ile Gln Thr Ser 
        35                  40                  45              


Ser Gln Thr Cys Trp Ala Ser Thr Leu Pro Gly Lys Leu Ser Phe Gln 
    50                  55                  60                  


Ser Leu Asp Arg Gln Phe Leu Phe His Ile 
65                  70                  


<210>  18
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  18

Phe Phe Pro Ile Arg Gly Cys Val Phe Ala Asp Gln Ser Val Leu Thr 
1               5                   10                  15      


Gln Pro Trp Glu Ala Ser Pro Val Ser Cys Ala Leu Pro Gly Arg Cys 
            20                  25                  30          


Glu Trp Arg Leu 
        35      


<210>  19
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  19

Phe Ser Glu Leu Arg Ile Ser Glu Asp Thr Met Val Gln Pro Gln Leu 
1               5                   10                  15      


Trp Gly Leu Gln Trp Ala Glu Pro Leu Val Cys Ser Arg Ser Gln Ala 
            20                  25                  30          


Gly Cys Arg Ala Ser Ser Ala Gln Ala His Thr Arg Ala Leu Arg Met 
        35                  40                  45              


Pro Gln Trp Ala Pro Ser Ala Leu 
    50                  55      


<210>  20
<211>  65
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Asn Phe Arg Arg Xaa Ser Val Leu Thr Gln Pro Asp Lys His Thr Gly 
1               5                   10                  15      


Leu Pro Val Pro Gly His Asp Tyr Pro Ala Ala Asp Leu Asn Asp Gln 
            20                  25                  30          


Glu Asp Ala His Glu Ser Asp Leu Val Trp Arg Val Ser Ala Trp Pro 
        35                  40                  45              


Leu Leu Tyr His Leu Lys Val Pro Leu Met Lys Asp Gln Leu Val Ala 
    50                  55                  60                  


Leu 
65  


