                         SEQUENCE LISTING

<110>  UNIVERSITE DE NANTES
       INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
       PARIS, Francois
       BIRKLE, Francois
       DESSELLE, Ariane
       AUBRY, Jacques
       GAUGLER, Marie-Helene
       COCHONNEAU, Denis
       CHAUMETTE, Tanguy
 
<120>  Anticorps anti-Gb3 utiles dans le traitement des maladies 
       associes  langiognse

<130>  360356D29067

<150>  FR 1150958
<151>  2011-02-07

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lourde-CDR1

<400>  1

Gly Phe Asp Phe Ser Arg Tyr Trp 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lourde-CDR2

<400>  2

Ile Asn Pro Asp Ser Ser Thr Ile 
1               5               


<210>  3
<211>  12
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lourde-CDR3

<400>  3

Ala Arg Gly Asp Tyr Tyr Gly Ser Arg Cys Asp Tyr 
1               5                   10          


<210>  4
<211>  6
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lgre-CDR1

<400>  4

Gln Asp Ile Lys Ser Tyr 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lgre-CDR2

<400>  5

Tyr Ala Thr 
1           


<210>  6
<211>  9
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lgre-CDR3

<400>  6

Leu Gln His Gly Glu Ser Pro Leu Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lourde-CDR1

<400>  7

Gly Phe Ser Leu Thr Gly Tyr Gly 
1               5               


<210>  8
<211>  7
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lourde-CDR2

<400>  8

Ile Trp Gly Asp Gly Ser Thr 
1               5           


<210>  9
<211>  11
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lourde-CDR3

<400>  9

Ala Arg Asn Gly Asn Tyr Leu Ala Phe Asp Tyr 
1               5                   10      


<210>  10
<211>  6
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lgre-CDR1

<400>  10

Gln Ser Ile Ser Asp Tyr 
1               5       


<210>  11
<211>  3
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lgre-CDR2

<400>  11

Tyr Ala Ser 
1           


<210>  12
<211>  9
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lgre-CDR3

<400>  12

Gln Asn Gly His Ser Phe Pro Leu Thr 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lourde-CDR1

<400>  13

Gly Tyr Ala Phe Ser Ser Ser Trp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lourde-CDR2

<400>  14

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  15
<211>  10
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lourde-CDR3

<400>  15

Ala Arg Gly Asp Arg Ala Trp Phe Ala Tyr 
1               5                   10  


<210>  16
<211>  7
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lgre-CDR1

<400>  16

Ser Ser Ile Ser Ser Asn Tyr 
1               5           


<210>  17
<211>  3
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lgre-CDR2

<400>  17

Arg Thr Ser 
1           


<210>  18
<211>  9
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lgre-CDR3

<400>  18

Gln Gln Gly Ser Ser Ile Pro Arg Thr 
1               5                   


<210>  19
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lourde-CDR1

<400>  19

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lourde-CDR2

<400>  20

Ile Tyr Pro Gly Ser Gly Ser Thr 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lourde-CDR3

<400>  21

Thr Arg Lys Phe Leu Phe Asp Tyr 
1               5               


<210>  22
<211>  6
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lgre-CDR1

<400>  22

Gln Ser Ile Ser Asn Tyr 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lgre-CDR2

<400>  23

Tyr Ala Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lgre-CDR3

<400>  24

Gln Gln Ser Asn Ser Trp Pro His Thr 
1               5                   


<210>  25
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lourde-CDR1

<400>  25

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lourde-CDR2

<400>  26

Ile His Pro Ser Asp Ser Glu Thr 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lourde-CDR3

<400>  27

Ala Gly Gly Asp Arg Tyr Gly Tyr 
1               5               


<210>  28
<211>  10
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lgre-CDR1

<400>  28

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  29
<211>  3
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lgre-CDR2

<400>  29

Ala Ala Ser 
1           


<210>  30
<211>  9
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lgre-CDR3

<400>  30

Gln Gln Ser Lys Glu Val Pro Arg Thr 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lourde-CDR1

<400>  31

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lourde-CDR2

<400>  32

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  33
<211>  5
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lourde-CDR3

<400>  33

Ala Ser Gly Val Tyr 
1               5   


<210>  34
<211>  11
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lgre-CDR1

<400>  34

Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr 
1               5                   10      


<210>  35
<211>  3
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lgre-CDR2

<400>  35

Leu Val Ser 
1           


<210>  36
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lgre-CDR3

<400>  36

Val Gln Gly Thr His Leu Asp Val 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lourde-CDR1

<400>  37

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lourde-CDR2

<400>  38

Ile Ser Asn Gly Gly Gly Ser Thr 
1               5               


<210>  39
<211>  10
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lourde-CDR3

<400>  39

Ala Arg Pro Thr Tyr Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  40
<211>  5
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lgre-CDR1

<400>  40

Ser Ser Val Ser Tyr 
1               5   


<210>  41
<211>  3
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lgre-CDR2

<400>  41

Ala Thr Ser 
1           


<210>  42
<211>  9
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lgre-CDR3

<400>  42

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  43
<211>  101
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lourde-Rgion variable

<400>  43

Glu Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr Trp Met 
1               5                   10                  15      


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu 
            20                  25                  30          


Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys Asp 
        35                  40                  45              


Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
    50                  55                  60                  


Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
65                  70                  75                  80  


Gly Asp Tyr Tyr Gly Ser Arg Cys Asp Tyr Trp Gly Gln Gly Thr Thr 
                85                  90                  95      


Leu Gln Ser Pro Gln 
            100     


<210>  44
<211>  101
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lourde-Rgion variable

<400>  44

Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
1               5                   10                  15      


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
            20                  25                  30          


Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
        35                  40                  45              


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    50                  55                  60                  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
65                  70                  75                  80  


Arg Asn Gly Asn Tyr Leu Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                85                  90                  95      


Leu Gln Ser Ser Ser 
            100     


<210>  45
<211>  90
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lourde-Rgion variable

<400>  45

Ala Ser Gly Tyr Ala Phe Ser Ser Ser Trp Met Asn Trp Val Lys Gln 
1               5                   10                  15      


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp 
            20                  25                  30          


Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr 
        35                  40                  45              


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
    50                  55                  60                  


Ser Val Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Asp Arg Ala Trp 
65                  70                  75                  80  


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                85                  90  


<210>  46
<211>  95
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lourde-Rgion variable

<400>  46

Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10                  15      


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asn Ile 
            20                  25                  30          


Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asp Glu Lys Phe Lys Ser Lys 
        35                  40                  45              


Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu 
    50                  55                  60                  


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Lys 
65                  70                  75                  80  


Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
                85                  90                  95  


<210>  47
<211>  95
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lourde-Rgion variable

<400>  47

Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Met Asn 
1               5                   10                  15      


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile 
            20                  25                  30          


His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys Asp Lys 
        35                  40                  45              


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
    50                  55                  60                  


Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Gly Gly 
65                  70                  75                  80  


Asp Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
                85                  90                  95  


<210>  48
<211>  94
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lourde-Rgion variable

<400>  48

Gln Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met 
1               5                   10                  15      


Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp 
            20                  25                  30          


Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly 
        35                  40                  45              


Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
    50                  55                  60                  


Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser 
65                  70                  75                  80  


Gly Val Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
                85                  90                  


<210>  49
<211>  100
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lourde-Rgion variable

<400>  49

Pro Glu Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5                   10                  15      


Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
            20                  25                  30          


Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
        35                  40                  45              


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
    50                  55                  60                  


Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
65                  70                  75                  80  


Arg Pro Thr Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                85                  90                  95      


Thr Val Ser Ser 
            100 


<210>  50
<211>  88
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lgre-Rgion variable

<400>  50

Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser Trp Tyr 
1               5                   10                  15      


Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile Tyr Tyr Ala Thr 
            20                  25                  30          


Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Asp Asp Thr Ala 
    50                  55                  60                  


Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Leu Thr Phe Gly Ala 
65                  70                  75                  80  


Gly Thr Lys Leu Glu Leu Lys Arg 
                85              


<210>  51
<211>  89
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lgre-Rgion variable

<400>  51

Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp 
1               5                   10                  15      


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala 
            20                  25                  30          


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        35                  40                  45              


Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val 
    50                  55                  60                  


Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr Phe Gly 
65                  70                  75                  80  


Ala Gly Thr Lys Leu Glu Leu Lys Arg 
                85                  


<210>  52
<211>  85
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lgre-Rgion variable

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Xaa Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His Trp 
1               5                   10                  15      


Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu Ile Tyr Arg Thr 
            20                  25                  30          


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        35                  40                  45              


Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu Ala Glu Asp Val 
    50                  55                  60                  


Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Ile Pro Arg Thr Phe Gly 
65                  70                  75                  80  


Gly Gly Thr Lys Leu 
                85  


<210>  53
<211>  88
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lgre-Rgion variable

<400>  53

Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu His Trp Tyr 
1               5                   10                  15      


Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser 
            20                  25                  30          


Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr Glu Asn Phe Gly 
    50                  55                  60                  


Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His Thr Phe Gly Ala 
65                  70                  75                  80  


Gly Thr Lys Leu Glu Leu Lys Arg 
                85              


<210>  54
<211>  88
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lgre-Rgion variable

<400>  54

Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10                  15      


Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
            20                  25                  30          


Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Met Glu Glu 
    50                  55                  60                  


Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys Glu Val Pro Arg 
65                  70                  75                  80  


Thr Phe Gly Gly Gly Thr Lys Leu 
                85              


<210>  55
<211>  87
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lgre-Rgion variable

<400>  55

Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr 
1               5                   10                  15      


Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu 
            20                  25                  30          


Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr 
        35                  40                  45              


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    50                  55                  60                  


Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly Thr His Leu Asp 
65                  70                  75                  80  


Val Arg Trp Arg His Gln Ala 
                85          


<210>  56
<211>  82
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lgre-Rgion variable

<400>  56

Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
1               5                   10                  15      


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            20                  25                  30          


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        35                  40                  45              


Tyr Ser Leu Thr Ile Ser Lys Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    50                  55                  60                  


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
65                  70                  75                  80  


Lys Leu 
        


<210>  57
<211>  304
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lourde-Rgion variable

<400>  57
tgaactctcc tgtgcagcct caggattcga ttttagtaga tactggatga gttgggtccg       60

gcaggctcca gggaaagggc tagaatggat tggagaaatt aatccagata gcagtacgat      120

aaactatacg ccatctctaa aggataaatt catcatctcc agagacaacg ccaaaaatac      180

gctgtacctg caaatgagca aagtgagatc tgaggacaca gccctttatt actgtgcaag      240

aggggattac tacggtagta gatgtgacta ctggggccaa ggcaccactc tccagtctcc      300

tcaa                                                                   304


<210>  58
<211>  305
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lourde-Rgion variable

<400>  58
gagcctgtcc atcacatgca ccgtctcagg gttctcatta accggctatg gtgtaaactg       60

ggttcgccag cctccaggaa agggtctgga gtggctggga atgatatggg gtgatggaag      120

cacagactat aattcagctc tcaaatccag actgagcatc agcaaggaca actccaagag      180

ccaagttttc ttaaaaatga acagtctgca aactgatgac acagccaggt actactgtgc      240

cagaaatggt aactacctcg cctttgacta ctggggccaa ggcaccactc tccagtcctc      300

ctcaa                                                                  305


<210>  59
<211>  272
<212>  DNA
<213>  mus musculus

<400>  59
aagcttctgg ctacgcattc agtagctctt ggatgaactg ggtgaagcag aggcctggac       60

agggtcttga gtggattgga cggatttatc ctggagatgg agatactaac tacaatggga      120

agttcaaggg caaggccaca ctgactgcag acaaatcctc cagcacagcc tacatgcagc      180

tcagcagcct gacctctgtg gactctgcgg tctatttctg tgcaagaggg gacagggcct      240

ggtttgctta ctggggccaa gggactctgg tc                                    272


<210>  60
<211>  287
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lourde-Rgion variable

<400>  60
gctgtcctgc aaggcttctg gctacacatt caccagctac tggatgcact gggtgaagca       60

gaggcctgga caaggccttg agtggattgg aaatatttat cctggtagtg gtagtactaa      120

ctacgatgag aagttcaaga gcaaggccac actgactgta gacacatcct ccagcacagc      180

ctacatgcag ctcagcagcc tgacatctga ggactctgcg gtctattact gtacaagaaa      240

gttcctcttt gactactggg gccaaggcac cactctcaca gtctcct                    287


<210>  61
<211>  288
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lourde-Rgion variable

<400>  61
gctgtcctgc aaggcttctg gctactcctt caccagctac tggatgaact gggtgaagca       60

gaggcctgga caaggccttg agtggattgg catgattcat ccttccgata gtgaaactag      120

gttaaatcag aagttcaagg acaaggccac attgactgta gacaaatcct ccagcacagc      180

ctacatgcaa ctcagcagcc cgacatctga ggactctgcg gtctattact gtgcaggggg      240

ggataggtac ggctactggg gccaaggcac cactctcaca gtctcctc                   288


<210>  62
<211>  285
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lourde-Rgion variable

<400>  62
gtcagatctc ctgcaaggct tctgggtata ccttcacaaa ctatggaatg aactgggtga       60

agcaggctcc aggaaagggt ttaaagtgga tgggctggat aaacacctac actggagagc      120

caacatatgc tgatgacttc aagggacggt ttgccttctc tttggaaacc tctgccagca      180

ctgcctattt gcagatcaac aacctcaaaa atgaggacac ggctacatat ttctgtgcaa      240

gtggggttta ctggggccaa ggcaccactc tcacagtctc ctcaa                      285


<210>  63
<211>  301
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lourde-Rgion variable

<400>  63
cctgaactct cctgtgcaac ctctggattc actttcagtg actattacat gtattgggtt       60

cgccagactc cagagaagag gctggagtgg gtcgcataca ttagtaatgg tggtggtagc      120

acctattatc cagacactgt aaagggccga ttcaccatct ccagagacaa tgccaagaac      180

accctgtacc tgcaaatgag ccgtctgaag tctgaggaca cagccatgta ttactgtgca      240

agaccgacgt atggttactt tgactactgg ggccaaggca ccactctcac agtctcctca      300

a                                                                      301


<210>  64
<211>  265
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 3E2-chaine lgre-Rgion variable

<400>  64
tatcacttgc aaggcgagtc aggacattaa aagctattta agctggtacc agcagaaacc       60

atggaaatct cctaagaccc tgatctatta tgcaacaagc ttggcagatg gggtcccatc      120

aagattcagt ggcagtggat ctgggcaaga ttattctcta accatcagca gcctggagtc      180

tgacgataca gcaacttatt actgtctaca gcatggtgag agcccgctca cgttcggtgc      240

tgggaccaag ctggagctga aacgg                                            265


<210>  65
<211>  267
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 14C11-chaine lgre-Rgion variable

<400>  65
tctctttcct gcagggccag ccagagtatt agcgactact tacactggta tcaacaaaaa       60

tcacatgagt ctccaaggct tctcatcaaa tatgcttccc aatccatctc tgggatcccc      120

tccaggttca gtggcagtgg atcagggtca gatttcactc tcagtatcaa cagtgtggaa      180

cctgaagatg ttggagtgta ttactgtcaa aatggtcaca gctttccgct cacgttcggt      240

gctgggacca agctggagct gaaacgg                                          267


<210>  66
<211>  254
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 15C11-chaine lgre-Rgion variable

<400>  66
tcacctgcag tgccagctca agtataagtt ccaattactt gcattggtat cagcagaagc       60

caggattctc ccctaaactc ttgatttata ggacatccaa tctggcttct ggagtcccag      120

ctcgcttcag tggcagtggg tctgggacct cttactctct cacaattggc accatggagg      180

ctgaagatgt tgccacttac tactgccagc agggtagtag tataccacgc acgttcggag      240

gggggaccaa gctg                                                        254


<210>  67
<211>  266
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 22F6-chaine lgre-Rgion variable

<400>  67
gtctttcctg cagggccagt caaagtatta gcaactacct acactggtat caacaaaaat       60

cacatgagtc tccaaggctt ctcatcaagt atgcttccca gtccatctct gggatcccct      120

ccaggttcag tggcagtgga tcagggacag atttcactct cagtatcaac agtgtggaga      180

ctgaaaattt tggaatgtat ttctgtcaac agagtaacag ctggcctcac acgttcggtg      240

ctgggaccaa gctggagctg aaacgg                                           266


<210>  68
<211>  266
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 25C10-chaine lgre-Rgion variable

<400>  68
ccatctcctg cagagccagc gaaagtgttg ataattatgg cattagtttt atgaactggt       60

tccaacagaa accaggacag ccacccaaac tcctcatcta tgctgcatcc aaccaaggat      120

ccggggtccc tgccaggttt agtggcagtg ggtctgggac agacttcagc ctcaacatcc      180

atcctatgga ggaggatgat actgcaatgt atttctgtca gcaaagtaag gaggttcctc      240

ggacgttcgg tggaggcacc aagctg                                           266


<210>  69
<211>  263
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 11E10-chaine lgre-Rgion variable

<400>  69
atctcttgca agtcaagtca gagcctctta tatagtaatg gaaaaaccta tttgaattgg       60

ttattacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      120

tctggagtcc ctgacaggtt cactggcagt ggatcaggaa cagattttac actgaaaatc      180

agcagagtgg aggctgagga tttgggagtt tattactgcg tgcaaggtac acatttggac      240

gttcggtgga ggcaccaagc tgg                                              263


<210>  70
<211>  250
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Anticorps 16G8-chaine lgre-Rgion variable

<400>  70
tgacttgcag ggccagctca agtgtaagtt acatgcactg gtaccagcag aagccaggat       60

cctcccccaa accctggatt tatgccacat ccaacctggc ttctggagtc cctgctcgct      120

tcagtggcag tgggtctggg acctcttact ctctcacaat cagcaaagtg gaggctgaag      180

atgctgccac ttattactgc cagcagtgga gtagtaaccc acccacgttc ggtgctggga      240

ccaagctgga                                                             250


<210>  71
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH1 A antisens

<400>  71
aggtgcagct tcaggagtca gg                                                22


<210>  72
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH1 B antisens

<400>  72
aggtgcagct agaggagtca gg                                                22


<210>  73
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH2 A antisens

<400>  73
aggtccagct gcagcagtca tg                                                22


<210>  74
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH2 B antisens

<400>  74
aggtccacct gcagcagcct gg                                                22


<210>  75
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH2 C antisens

<400>  75
aggtccagct gcagcagtct gg                                                22


<210>  76
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH3 A antisens

<400>  76
aggtgaagct ggtggagtct gg                                                22


<210>  77
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH3 B antisens

<400>  77
aggtgaagct tctcgagtct gg                                                22


<210>  78
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH3 C antisens

<400>  78
aagtgaagct tgaggagtct gg                                                22


<210>  79
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH3 D antisens

<400>  79
aagtgatgct ggtggagtcg tg                                                22


<210>  80
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VH5 antisens

<400>  80
aggttcagct ccagcagtct gg                                                22


<210>  81
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR JH1 sens

<400>  81
tgaggagacg gtgaccgtgg tccc                                              24


<210>  82
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR JH2 sens

<400>  82
tgaggagact gtgagagtgg tgcc                                              24


<210>  83
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR JH3 sens

<400>  83
tgcagagaca gtgaccagag tccc                                              24


<210>  84
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR JH4 sens

<400>  84
tgaggagacg gtgactgagg ttcc                                              24


<210>  85
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VkA antisens

<400>  85
gatgttttga tgacccaaac tcca                                              24


<210>  86
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VkB antisens

<400>  86
gatattgtga taacccagga tgaa                                              24


<210>  87
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VkC antisens

<400>  87
gacattgtgc tracccartc tcca                                              24


<210>  88
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VkD antisens


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  88
gacatccaga tgacncagtc tcca                                              24


<210>  89
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VkE antisens

<400>  89
caaattgttc tcacccagtc tcca                                              24


<210>  90
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR VkF antisens

<400>  90
gaaaatgtgc tcacccagtc tcca                                              24


<210>  91
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR Jk1 sens

<400>  91
ccgtttgatc agcttggtgc c                                                 21


<210>  92
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR Jk2 sens

<400>  92
ccgttttatt tccagcttgg tccc                                              24


<210>  93
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR Jk3 sens

<400>  93
ccgttttatt tccaactttg tccc                                              24


<210>  94
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Amorce PCR Jk4 sens

<400>  94
ccgtttcagc tccagcttgg tccc                                              24


