                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  Mutant Interleukin-2 Polypeptides

<130>  27307

<150>  EP 11153964.9
<151>  2011-02-10

<150>  EP 11164237.7
<151>  2011-04-29

<160>  324   

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  2
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type human IL-2

<400>  2
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct tttgtcaaag catcatctca acactgact                             399


<210>  3
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild-type human IL-2 (C125A)

<400>  3

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  4
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type human IL-2 (C125A) (1)

<400>  4
gctcctacat cctccagcac caagaaaacc cagctccagc tggaacatct cctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacctggccc agtccaagaa cttccacctg      240

aggcctcggg acctgatctc caacatcaac gtgatcgtgc tggaactgaa gggctccgag      300

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagtc catcatctcc accctgacc                             399


<210>  5
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type human IL-2 (C125A) (2)

<400>  5
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  6
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type human IL-2 (C125A) (3)

<400>  6
gctcctacta gcagctccac caagaaaacc cagctccagc tggaacatct gctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accttcaagt tctacatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacctggccc agagcaagaa cttccacctg      240

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa gggcagcgag      300

acaaccttca tgtgcgagta cgccgacgag acagccacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagag catcatcagc accctgaca                             399


<210>  7
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant L72G (C125A)

<400>  7

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  8
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant L72G (C125A) (1)

<400>  8
gctcctacat cctccagcac caagaaaacc cagctccagc tggaacatct cctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agtccaagaa cttccacctg      240

aggcctcggg acctgatctc caacatcaac gtgatcgtgc tggaactgaa gggctccgag      300

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagtc catcatctcc accctgacc                             399


<210>  9
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant L72G (C125A) (2)

<400>  9
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  10
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant L72G (C125A) (3)

<400>  10
gctcctacta gcagctccac caagaaaacc cagctccagc tggaacatct gctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accttcaagt tctacatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agagcaagaa cttccacctg      240

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa gggcagcgag      300

acaaccttca tgtgcgagta cgccgacgag acagccacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagag catcatcagc accctgaca                             399


<210>  11
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant L72G / F42A (C125A)

<400>  11

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  12
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant F42A / L72G (C125A) (1)

<400>  12
gctcctacat cctccagcac caagaaaacc cagctccagc tggaacatct cctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accgccaagt tctacatgcc caagaaggcc accgagctga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agtccaagaa cttccacctg      240

aggcctcggg acctgatctc caacatcaac gtgatcgtgc tggaactgaa gggctccgag      300

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagtc catcatctcc accctgacc                             399


<210>  13
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant F42A / L72G (C125A) (2)

<400>  13
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acagccaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  14
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant F42A / L72G (C125A) (3)

<400>  14
gctcctacta gcagctccac caagaaaacc cagctccagc tggaacatct gctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accgccaagt tctacatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agagcaagaa cttccacctg      240

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa gggcagcgag      300

acaaccttca tgtgcgagta cgccgacgag acagccacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagag catcatcagc accctgaca                             399


<210>  15
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 triple mutant F42A / Y45A / L72G (C125A)

<400>  15

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  16
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 triple mutant F42A / Y45A / L72G (C125A) (1)

<400>  16
gctcctacat cctccagcac caagaaaacc cagctccagc tggaacatct cctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accgccaagt tcgccatgcc caagaaggcc accgagctga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agtccaagaa cttccacctg      240

aggcctcggg acctgatctc caacatcaac gtgatcgtgc tggaactgaa gggctccgag      300

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagtc catcatctcc accctgacc                             399


<210>  17
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 triple mutant F42A / Y45A / L72G (C125A) (2)

<400>  17
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  18
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 triple mutant F42A / Y45A / L72G (C125A) (3)

<400>  18
gctcctacta gcagctccac caagaaaacc cagctccagc tggaacatct gctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accgccaagt tcgccatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agagcaagaa cttccacctg      240

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa gggcagcgag      300

acaaccttca tgtgcgagta cgccgacgag acagccacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagag catcatcagc accctgaca                             399


<210>  19
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 quadruple mutant T3A / F42A / Y45A / L72G (C125A)

<400>  19

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  20
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 quadruple mutant T3A / F42A / Y45A / L72G (C125A) (1)

<400>  20
gctcctgcct cctccagcac caagaaaacc cagctccagc tggaacatct cctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accgccaagt tcgccatgcc caagaaggcc accgagctga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agtccaagaa cttccacctg      240

aggcctcggg acctgatctc caacatcaac gtgatcgtgc tggaactgaa gggctccgag      300

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagtc catcatctcc accctgacc                             399


<210>  21
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 quadruple mutant T3A / F42A / Y45A / L72G (C125A) (2)

<400>  21
gcacctgcct caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  22
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 quadruple mutant T3A / F42A / Y45A / L72G (C125A) (3)

<400>  22
gctcctgcca gcagctccac caagaaaacc cagctccagc tggaacatct gctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accgccaagt tcgccatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      180

gaggaactga agcctctgga agaggtgctg aacggcgccc agagcaagaa cttccacctg      240

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa gggcagcgag      300

acaaccttca tgtgcgagta cgccgacgag acagccacca tcgtggaatt tctgaaccgg      360

tggatcacct tcgcccagag catcatcagc accctgaca                             399


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10; VL

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  24
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10; VL

<400>  24
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10(GS); VL

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10(GS); VL

<400>  26
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  27
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10; VH

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10; VH

<400>  28
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  29
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11; VL

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Tyr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  30
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11; VL

<400>  30
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcgtccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagt atactccccc cacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  31
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11(VI); VL

<400>  31

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Tyr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  32
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11(VI); VL

<400>  32
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagt atactccccc cacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  33
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11; VH

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Arg Trp Met Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  34
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11; VH

<400>  34
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac atggccgtat attactgtgc gaaatggaga      300

tggatgatgt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  35
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11(MT); VH

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Arg Trp Met Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11(MT); VH

<400>  36
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac accgccgtat attactgtgc gaaatggaga      300

tggatgatgt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  37
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2; VL

<400>  37

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Tyr Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  38
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2; VL

<400>  38
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt atccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  39
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2(YS); VL

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  40
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2(YS); VL

<400>  40
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  41
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2; VH

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  42
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2; VH

<400>  42
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  43
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9, VL

<400>  43

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Leu Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  44
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9, VL

<400>  44
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  45
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9, VH

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  46
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9, VH

<400>  46
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccagact      120

ccagggaagg ggctggagtg ggtctcagct attggtgtta gtactggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9(TA); VH

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  48
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9(TA); VH

<400>  48
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attggtgtta gtactggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  49
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8; VL

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  50
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8; VL

<400>  50
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggacg gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  51
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8; VH

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  52
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8; VH

<400>  52
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  53
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3; VL

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Tyr Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  54
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3; VL

<400>  54
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcaattact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcgcctaca tcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  55
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3; VH

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  56
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3; VH

<400>  56
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  57
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D6; VL

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Gln Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  58
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4D6; VL

<400>  58
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatccag ggcgcctcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  59
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D6; VH

<400>  59

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  60
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4D6; VH

<400>  60
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  61
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C6; VL

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  62
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C6; VL

<400>  62
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag caggctggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc agattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  63
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C6; VH

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Ala Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  64
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C6; VH

<400>  64
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatc cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggga gtgctggtta tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttgggaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  65
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5H5; VL

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  66
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5H5; VL

<400>  66
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt      300

caggggacca aagtggaaat caaa                                             324


<210>  67
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5H5; VH

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Arg Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  68
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5H5; VH

<400>  68
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatacca tgagctgggt ccgccggtct      120

ccagggaagg ggctggagtg ggtctcagct attagtggtg gtggtaggac atactacgca      180

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa aggttggttt      300

acgccttttg actactgggg ccaaggaacc ctggtcaccg tctcgagt                   348


<210>  69
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C4; VL

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  70
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C4; VL

<400>  70
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agtaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcctcca ttagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt      300

caggggacca aagtggaaat caaa                                             324


<210>  71
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C4; VH

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  72
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C4; VH

<400>  72
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttacgcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  73
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D9; VL

<400>  73

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  74
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D9; VL

<400>  74
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt      300

caggggacca aagtggaaat caaa                                             324


<210>  75
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D9; VH

<400>  75

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  76
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D9; VH

<400>  76
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttacgcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  77
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B8; VL

<400>  77

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  78
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B8; VL

<400>  78
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  79
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B8; VH

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  80
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B8; VH

<400>  80
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  81
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A1; VL

<400>  81

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  82
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7A1; VL

<400>  82
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc agattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  83
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A1; VH

<400>  83

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  84
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7A1; VH

<400>  84
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttgggaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  85
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13C2; VL

<400>  85

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Leu Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  86
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13C2; VL

<400>  86
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  87
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13C2; VH

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  88
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13C2; VH

<400>  88
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  89
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E8; VL

<400>  89

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Asn Ile Pro 
                85                  90                  95      


Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  90
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13E8; VL

<400>  90
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtctga atattccctc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  91
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E8; VH

<400>  91

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  92
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13E8; VH

<400>  92
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ttgggtccgt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  93
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14C10; VL

<400>  93

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly His Ile Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  94
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14C10; VL

<400>  94
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcata ttattccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  95
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14C10; VH

<400>  95

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Trp Met Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  96
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14C10; VH

<400>  96
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagcttgg      300

atggggcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  97
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17A11; VL

<400>  97

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Asn Ile Pro 
                85                  90                  95      


Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  98
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17A11; VL

<400>  98
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtctga atattccctc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  99
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17A11; VH

<400>  99

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  100
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17A11; VH

<400>  100
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ttgggtccgt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  101
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19G1; VL

<400>  101

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  102
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  19G1; VL

<400>  102
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  103
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19G1; VH

<400>  103

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Ser Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  104
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  19G1; VH

<400>  104
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagcg attattagta gtggtggtct cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  105
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G8; VL

<400>  105

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  106
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20G8; VL

<400>  106
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G8; VH

<400>  107

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  108
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20G8; VH

<400>  108
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcaa tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggga gtggtagtcg tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  109
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B9; VL

<400>  109

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  110
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B9; VL

<400>  110
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  111
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B9; VH

<400>  111

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  112
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B9; VH

<400>  112
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtgctag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  113
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B8; VL

<400>  113

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  114
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5B8; VL

<400>  114
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  115
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B8; VH

<400>  115

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Gly Gly Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  116
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5B8; VH

<400>  116
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct atttggggtg gtggtcgtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  117
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F1; VL

<400>  117

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  118
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5F1; VL

<400>  118
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  119
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F1; VH

<400>  119

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Ser Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  120
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5F1; VH

<400>  120
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattagta gtggggctag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  121
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14B3; VL

<400>  121

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  122
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14B3; VL

<400>  122
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  123
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14B3; VH

<400>  123

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Gly Ala Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  124
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14B3; VH

<400>  124
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attttggcta gtggtgcgat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  125
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F1; VL

<400>  125

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  126
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F1; VL

<400>  126
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  127
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F1; VH

<400>  127

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  128
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F1; VH

<400>  128
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attattggta gtggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  129
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F8; VL

<400>  129

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  130
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F8; VL

<400>  130
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  131
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F8; VH

<400>  131

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  132
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F8; VH

<400>  132
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attcttggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  133
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O3C9; VL

<400>  133

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  134
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O3C9; VL

<400>  134
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  135
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O3C9; VH

<400>  135

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  136
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O3C9; VH

<400>  136
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttttgcca tgagctgggt ccgtcagtct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtagtaa cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  137
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O2D7; VL

<400>  137

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  138
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O2D7; VL

<400>  138
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcacccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag caggctatta tgcttcctcc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  139
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O2D7; VH

<400>  139

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  140
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O2D7; VH

<400>  140
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  141
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1; VL

<400>  141

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  142
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28H1; VL

<400>  142
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  143
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1; VH

<400>  143

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  144
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28H1; VH

<400>  144
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agtcatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct atttgggcta gtggggagca atactacgca      180

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa agggtggctg      300

ggtaattttg actactgggg ccaaggaacc ctggtcaccg tctcgagt                   348


<210>  145
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22A3; VL

<400>  145

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  146
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  22A3; VL

<400>  146
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  147
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22A3; VH

<400>  147

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  148
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  22A3; VH

<400>  148
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtagtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  149
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29B11; VL

<400>  149

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  150
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29B11; VL

<400>  150
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  151
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29B11; VH

<400>  151

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  152
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29B11; VH

<400>  152
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  153
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23C10; VL

<400>  153

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  154
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  23C10; VL

<400>  154
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  155
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23C10; VH

<400>  155

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Thr Asn Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  156
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  23C10; VH

<400>  156
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttctgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtacta atggtaatta tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  157
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VL

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  158
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VL

<400>  158
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  159
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VH

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  160
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VH

<400>  160
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggagct atcatcccga tccttggtat cgcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  161
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VL

<400>  161

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  162
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VL

<400>  162
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  163
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VH

<400>  163

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  164
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VH

<400>  164
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctatgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggagtg atcatcccta tccttggtac cgcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  165
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VL

<400>  165

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ser Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  166
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VL

<400>  166
gacatccaga tgacccagtc tccttcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat tcgtccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  167
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VH

<400>  167

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  168
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VH

<400>  168
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  169
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VL

<400>  169

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  170
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VL

<400>  170
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca ggggattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gcttacagct tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  171
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VH

<400>  171

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  172
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VH

<400>  172
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  173
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VL

<400>  173

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  174
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VL

<400>  174
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca ggggattcgt aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gcttacagct tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  175
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VH

<400>  175

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  176
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VH

<400>  176
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  177
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VL

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  178
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VL

<400>  178
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gagcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gtgtccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  179
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VH

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  180
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VH

<400>  180
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  181
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VL

<400>  181

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  182
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VL

<400>  182
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gcgtccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcctgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  183
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VH

<400>  183

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  184
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VH

<400>  184
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  185
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VL

<400>  185

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Gln Ala Ala Thr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  186
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VL

<400>  186
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatccaggct gctaccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  187
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VH

<400>  187

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  188
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VH

<400>  188
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  189
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHLG1; VH

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  190
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHLG1; VH

<400>  190
gaagtgcagc tggtggagtc tggaggaggc ttggtcaagc ctggcgggtc cctgcggctc       60

tcctgtgcag cctccggatt cacatttagc aactattgga tgaactgggt gcggcaggct      120

cctggaaagg gcctcgagtg ggtggccgag atcagattga aatccaataa cttcggaaga      180

tattacgctg caagcgtgaa gggccggttc accatcagca gagatgattc caagaacacg      240

ctgtacctgc agatgaacag cctgaagacc gaggatacgg ccgtgtatta ctgtaccaca      300

tacggcaact acgttgggca ctacttcgac cactggggcc aagggaccac cgtcaccgtc      360

tccagt                                                                 366


<210>  191
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KV9; VL

<400>  191

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  192
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KV9; VL

<400>  192
gatatccagt tgacccagtc tccatccttc ctgtctgcat ctgtgggcga ccgggtcacc       60

atcacctgca aggccagtca gaatgtggat actaacgtgg cttggtacca gcagaagcca      120

gggcaggcac ctaggcctct gatctattcg gcatcctacc ggtacactgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca caatctcaag cctgcaacct      240

gaagatttcg caacttacta ctgtcaacag tacaatagtt accctctgac gttcggcgga      300

ggtaccaagg tggagatcaa gcgtacg                                          327


<210>  193
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHLG; VH

<400>  193

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  194
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHLG; VH

<400>  194
gaagtgcagc tggtggagtc tggaggaggc ttggtccagc ctggcgggtc cctgcggctc       60

tcctgtgcag cctccggatt cacatttagc aactattgga tgaactgggt gcggcaggct      120

cctggaaagg gcctcgagtg ggtggccgag atcagattga aatccaataa cttcggaaga      180

tattacgctg caagcgtgaa gggccggttc accatcagca gagatgattc caagaacacg      240

ctgtacctgc agatgaacag cctgaagacc gaggatacgg ccgtgtatta ctgtaccaca      300

tacggcaact acgttgggca ctacttcgac cactggggcc aagggaccac cgtcaccgtc      360

tccagt                                                                 366


<210>  195
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KV1; VL

<400>  195

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  196
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KV1; VL

<400>  196
gatatccagt tgacccagtc tccatccttc ctgtctgcat ctgtgggcga ccgggtcacc       60

atcacctgca gggccagtca gaatgtggat actaacttag cttggtacca gcagaagcca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gttacactgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca caatctcaag cctgcaacct      240

gaagatttcg caacttacta ctgtcaacag tacaatagtt accctctgac gttcggcgga      300

ggtaccaagg tggagatcaa gcgtacggtg                                       330


<210>  197
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KV7; VL

<400>  197

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  198
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KV7; VL

<400>  198
gatatccagt tgacccagtc tccatccttc ctgtctgcat ctgtgggcga ccgggtcacc       60

atcacctgca aggccagtca gaatgtggat actaacgtgg cttggtacca gcagaagcca      120

gggaaagcac ctaagcctct gatctattcg gcatcctacc ggtacactgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca caatctcaag cctgcaacct      240

gaagatttcg caacttacta ctgtcaacag tacaatagtt accctctgac gttcggcgga      300

ggtaccaagg tggagatcaa gcgtacggtg                                       330


<210>  199
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  199

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser Ser 
225                 230                 235                 240 


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
                245                 250                 255     


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
            260                 265                 270         


Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu Leu 
        275                 280                 285             


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
    290                 295                 300                 


Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
305                 310                 315                 320 


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
                325                 330                 335     


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
            340                 345                 350         


Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu Thr 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu 
    370                 375                 380                 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
385                 390                 395                 400 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ser 
                405                 410                 415     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            420                 425                 430         


Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
        435                 440                 445             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
    450                 455                 460                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
            500                 505                 510         


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
        515                 520                 525             


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
    530                 535                 540                 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
545                 550                 555                 560 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
                565                 570                 575     


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
            580                 585                 590         


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600             


<210>  200
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  200
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agtttttcga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatct atttccggta gttcgggtac cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt      300

ccgtattttg actactgggg ccagggaacc ctggtcaccg tctcgagtgc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gataagaaag ttgagcccaa atcttgtgac      660

tccggcggag gagggagcgg cggaggtggc tccggaggtg gcggagcacc tgcctcaagt      720

tctacaaaga aaacacagct acaactggag catttactgc tggatttaca gatgattttg      780

aatggaatta ataattacaa gaatcccaaa ctcaccagga tgctcacagc caagtttgcc      840

atgcccaaga aggccacaga actgaaacat cttcagtgtc tagaagaaga actcaaacct      900

ctggaggaag tgctaaatgg cgctcaaagc aaaaactttc acttaagacc cagggactta      960

atcagcaata tcaacgtaat agttctggaa ctaaagggat ctgaaacaac attcatgtgt     1020

gaatatgctg atgagacagc aaccattgta gaatttctga acagatggat tacctttgcc     1080

caaagcatca tctcaacact gacttccggc ggaggaggat ccggcggagg tggctctggc     1140

ggtggcggag aggtgcagct gttggagtct gggggaggct tggtacagcc tggggggtcc     1200

ctgagactct cctgtgcagc ctctggattc acctttagca gtttttcgat gagctgggtc     1260

cgccaggctc cagggaaggg gctggagtgg gtctcatcta tttccggtag ttcgggtacc     1320

acatactacg cagactccgt gaagggccgg ttcaccatct ccagagacaa ttccaagaac     1380

acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtata ttactgtgcg     1440

aaaccgtttc cgtattttga ctactggggc cagggaaccc tggtcaccgt ctcgagtgct     1500

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     1560

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg     1620

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     1680

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     1740

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg ataagaaagt tgagcccaaa     1800

tcttgtgac                                                             1809


<210>  201
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 light chain

<400>  201

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  202
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 light chain

<400>  202
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat tatgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagacgggtc gtattcctcc gacgttcggc      300

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  203
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F16 scFv-IL2 qm-scFv

<400>  203

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala His Asn Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu 
    130                 135                 140                 


Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr 
145                 150                 155                 160 


Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
                165                 170                 175     


Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln 
        195                 200                 205             


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Val Tyr Thr Met 
    210                 215                 220                 


Pro Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
225                 230                 235                 240 


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ala Pro 
                245                 250                 255     


Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu 
            260                 265                 270         


Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro 
        275                 280                 285             


Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala 
    290                 295                 300                 


Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu 
305                 310                 315                 320 


Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro 
                325                 330                 335     


Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly 
            340                 345                 350         


Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile 
        355                 360                 365             


Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser 
    370                 375                 380                 


Thr Leu Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu 
                405                 410                 415     


Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr 
            420                 425                 430         


Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
        435                 440                 445             


Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    450                 455                 460                 


Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln 
465                 470                 475                 480 


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Val Tyr Thr Met 
                485                 490                 495     


Pro Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Glu Val 
        515                 520                 525             


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    530                 535                 540                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met 
545                 550                 555                 560 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
                565                 570                 575     


Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            580                 585                 590         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        595                 600                 605             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    610                 615                 620                 


Ala His Asn Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
625                 630                 635                 640 


Ser 
    


<210>  204
<211>  1923
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F16 scFv-IL2 qm-scFv

<400>  204
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc cggtatggta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagcgcat      300

aatgcttttg actactgggg ccagggaacc ctggtcaccg tgtcgagagg tggaggcggt      360

tcaggcggag gtggctctgg cggtggcgga tcgtctgagc tgactcagga ccctgctgtg      420

tctgtggcct tgggacagac agtcaggatc acatgccaag gagacagcct cagaagctat      480

tatgcaagct ggtaccagca gaagccagga caggcccctg tacttgtcat ctatggtaaa      540

aacaaccggc cctcagggat cccagaccga ttctctggct ccagctcagg aaacacagct      600

tccttgacca tcactggggc tcaggcggaa gatgaggctg actattactg taactcctct      660

gtttatacta tgccgcccgt ggtattcggc ggagggacca agctgaccgt cctaggctct      720

tcctcatcgg gtagtagctc ttccggctca tcgtcctccg gagcacctgc ctcaagttct      780

acaaagaaaa cacagctaca actggagcat ttactgctgg atttacagat gattttgaat      840

ggaattaata attacaagaa tcccaaactc accaggatgc tcacagccaa gtttgccatg      900

cccaagaagg ccacagaact gaaacatctt cagtgtctag aagaagaact caaacctctg      960

gaggaagtgc taaatggcgc tcaaagcaaa aactttcact taagacccag ggacttaatc     1020

agcaatatca acgtaatagt tctggaacta aagggatctg aaacaacatt catgtgtgaa     1080

tatgctgatg agacagcaac cattgtagaa tttctgaaca gatggattac ctttgcccaa     1140

agcatcatct caacactgac ttccggcgga ggagggagcg gcggaggtgg ctctggcggt     1200

ggcggatcgt ctgagctcac tcaggaccct gctgtgtctg tggccttggg acagacagtc     1260

aggatcacat gccaaggaga cagcctcaga agctattatg caagctggta ccagcagaag     1320

ccaggacagg cccctgtact tgtcatctat ggtaaaaaca accggccctc agggatccca     1380

gaccgattct ctggctccag ctcaggaaac acagcttcct tgaccatcac tggggctcag     1440

gcggaagatg aggctgacta ttactgtaac tcctctgttt atactatgcc gcccgtggta     1500

ttcggcggag ggaccaagct taccgtacta ggctcaggag gcggttcagg cggaggttct     1560

ggcggcggta gcggatcgga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct     1620

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagccg gtatggtatg     1680

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt     1740

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat     1800

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtatat     1860

tactgtgcga aagcgcataa tgcttttgac tactggggcc agggaaccct ggtcaccgtg     1920

tcg                                                                   1923


<210>  205
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F16 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  205

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala His Asn Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Ser Ser Ser 
    210                 215                 220                 


Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ala Pro Ala Ser Ser 
225                 230                 235                 240 


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
                245                 250                 255     


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
            260                 265                 270         


Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu Leu 
        275                 280                 285             


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
    290                 295                 300                 


Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
305                 310                 315                 320 


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
                325                 330                 335     


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
            340                 345                 350         


Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu Thr 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu 
    370                 375                 380                 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
385                 390                 395                 400 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly 
                405                 410                 415     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            420                 425                 430         


Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
        435                 440                 445             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
    450                 455                 460                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Lys Ala His Asn Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
            500                 505                 510         


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
        515                 520                 525             


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
    530                 535                 540                 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
545                 550                 555                 560 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
                565                 570                 575     


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
            580                 585                 590         


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600             


<210>  206
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F16 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  206
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc cggtatggta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagcgcat      300

aatgcttttg actactgggg ccagggaacc ctggtcaccg tgtcgagtgc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gataagaaag ttgagcccaa atcttgtgac      660

tcttcctcat cgggtagtag ctcttccggc tcatcgtcct ccggagcacc tgcctcaagt      720

tctacaaaga aaacacagct acaactggag catttactgc tggatttaca gatgattttg      780

aatggaatta ataattacaa gaatcccaaa ctcaccagga tgctcacagc caagtttgcc      840

atgcccaaga aggccacaga actgaaacat cttcagtgtc tagaagaaga actcaaacct      900

ctggaggaag tgctaaatgg cgctcaaagc aaaaactttc acttaagacc cagggactta      960

atcagcaata tcaacgtaat agttctggaa ctaaagggat ctgaaacaac attcatgtgt     1020

gaatatgctg atgagacagc aaccattgta gaatttctga acagatggat tacctttgcc     1080

caaagcatca tctcaacact gacttccggc ggaggaggga gcggcggagg tggctctggc     1140

ggtggcggag aggtgcaatt gttggagtct gggggaggct tggtacagcc tggggggtcc     1200

ctgagactct cctgtgcagc ctctggattc acctttagcc ggtatggtat gagctgggtc     1260

cgccaggctc cagggaaggg gctggagtgg gtctcagcta ttagtggtag tggtggtagc     1320

acatactacg cagactccgt gaagggccgg ttcaccatct ccagagacaa ttccaagaac     1380

acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtata ttactgtgcg     1440

aaagcgcata atgcttttga ctactggggc cagggaaccc tggtcaccgt gtcgagtgct     1500

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     1560

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg     1620

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     1680

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     1740

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa     1800

tcttgtgac                                                             1809


<210>  207
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F16 light chain

<400>  207

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Val Tyr Thr Met Pro Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  208
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F16 light chain

<400>  208
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcctct gtttatacta tgccgcccgt ggtattcggc      300

ggagggacca agctgaccgt cctaggtcaa cccaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggaact gcaggccaac aaggccaccc tggtctgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaaaac cgtggccccc accgagtgca gc                         642


<210>  209
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  209

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  210
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  210
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag tgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggataaga aagttgagcc caaatcttgt      660

gactccggcg gaggagggag cggcggaggt ggctccggag gtggcggagc acctgcctca      720

agttctacaa agaaaacaca gctacaactg gagcatttac tgctggattt acagatgatt      780

ttgaatggaa ttaataatta caagaatccc aaactcacca ggatgctcac agccaagttt      840

gccatgccca agaaggccac agaactgaaa catcttcagt gtctagaaga agaactcaaa      900

cctctggagg aagtgctaaa tggcgctcaa agcaaaaact ttcacttaag acccagggac      960

ttaatcagca atatcaacgt aatagttctg gaactaaagg gatctgaaac aacattcatg     1020

tgtgaatatg ctgatgagac agcaaccatt gtagaatttc tgaacagatg gattaccttt     1080

gcccaaagca tcatctcaac actgacttcc ggcggaggag gatccggcgg aggtggctct     1140

ggcggtggcg gagaggtgca attgttggag tctgggggag gcttggtaca gcctgggggg     1200

tccctgagac tctcctgtgc agcctccgga ttcaccttta gcagttatgc catgagctgg     1260

gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtgg tagtggtggt     1320

agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga caattccaag     1380

aacacgctgt atctgcagat gaacagcctg agagccgagg acacggccgt atattactgt     1440

gcgaaagggt ggtttggtgg ttttaactac tggggccaag gaaccctggt caccgtctcg     1500

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     1560

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg     1620

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     1680

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     1740

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag     1800

cccaaatctt gtgac                                                      1815


<210>  211
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  211

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  212
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  212
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggataaga aagttgagcc caaatcttgt      660

gactccggcg gaggagggag cggcggaggt ggctccggag gtggcggagc acctgcctca      720

agttctacaa agaaaacaca gctacaactg gagcatttac tgctggattt acagatgatt      780

ttgaatggaa ttaataatta caagaatccc aaactcacca ggatgctcac agccaagttt      840

gccatgccca agaaggccac agaactgaaa catcttcagt gtctagaaga agaactcaaa      900

cctctggagg aagtgctaaa tggcgctcaa agcaaaaact ttcacttaag acccagggac      960

ttaatcagca atatcaacgt aatagttctg gaactaaagg gatctgaaac aacattcatg     1020

tgtgaatatg ctgatgagac agcaaccatt gtagaatttc tgaacagatg gattaccttt     1080

gcccaaagca tcatctcaac actgacttcc ggcggaggag gatccggcgg aggtggctct     1140

ggcggtggcg gagaggtgca attgttggag tctgggggag gcttggtaca gcctgggggg     1200

tccctgagac tctcctgtgc agcctccgga ttcaccttta gcagttatgc catgagctgg     1260

gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtgg tagtggtggt     1320

agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga caattccaag     1380

aacacgctgt atctgcagat gaacagcctg agagccgagg acacggccgt atattactgt     1440

gcgaaagggt ggctgggtaa ttttgactac tggggccaag gaaccctggt caccgtctcg     1500

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     1560

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg     1620

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     1680

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     1740

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag     1800

cccaaatctt gtgac                                                      1815


<210>  213
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  213

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  214
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  214
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccagact      120

ccagggaagg ggctggagtg ggtctcagct attggtgtta gtactggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggataaga aagttgagcc caaatcttgt      660

gactccggcg gaggagggag cggcggaggt ggctccggag gtggcggagc acctgcctca      720

agttctacaa agaaaacaca gctacaactg gagcatttac tgctggattt acagatgatt      780

ttgaatggaa ttaataatta caagaatccc aaactcacca ggatgctcac agccaagttt      840

gccatgccca agaaggccac agaactgaaa catcttcagt gtctagaaga agaactcaaa      900

cctctggagg aagtgctaaa tggcgctcaa agcaaaaact ttcacttaag acccagggac      960

ttaatcagca atatcaacgt aatagttctg gaactaaagg gatctgaaac aacattcatg     1020

tgtgaatatg ctgatgagac agcaaccatt gtagaatttc tgaacagatg gattaccttt     1080

gcccaaagca tcatctcaac actgacttcc ggcggaggag gatccggcgg aggtggctct     1140

ggcggtggcg gagaggtgca attgttggag tctgggggag gcttggtaca gcctgggggg     1200

tccctgagac tctcctgtgc agcctccgga ttcaccttta gcagttatgc tatgagctgg     1260

gtccgccaga ctccagggaa ggggctggag tgggtctcag ctattggtgt tagtactggt     1320

agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga caattccaag     1380

aacacgctgt atctgcagat gaacagcctg agagccgagg acacggccgt atattactgt     1440

gcgaaaggtt ggctgggtcc ttttgactac tggggccaag gaaccctggt caccgtctcg     1500

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     1560

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg     1620

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     1680

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     1740

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag     1800

cccaaatctt gtgac                                                      1815


<210>  215
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Arg Trp Met Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Trp Arg Trp Met Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  216
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  216
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac accgccgtat attactgtgc gaaatggaga      300

tggatgatgt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggataaga aagttgagcc caaatcttgt      660

gactccggcg gaggagggag cggcggaggt ggctccggag gtggcggagc acctgcctca      720

agttctacaa agaaaacaca gctacaactg gagcatttac tgctggattt acagatgatt      780

ttgaatggaa ttaataatta caagaatccc aaactcacca ggatgctcac agccaagttt      840

gccatgccca agaaggccac agaactgaaa catcttcagt gtctagaaga agaactcaaa      900

cctctggagg aagtgctaaa tggcgctcaa agcaaaaact ttcacttaag acccagggac      960

ttaatcagca atatcaacgt aatagttctg gaactaaagg gatctgaaac aacattcatg     1020

tgtgaatatg ctgatgagac agcaaccatt gtagaatttc tgaacagatg gattaccttt     1080

gcccaaagca tcatctcaac actgacttcc ggcggaggag gatccggcgg aggtggctct     1140

ggcggtggcg gagaggtgca attgttggag tctgggggag gcttggtaca gcctgggggg     1200

tccctgagac tctcctgtgc agcctccgga ttcaccttta gcagttatgc catgagctgg     1260

gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtgg tagtggtggt     1320

agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga caattccaag     1380

aacacgctgt atctgcagat gaacagcctg agagccgagg acaccgccgt atattactgt     1440

gcgaaatgga gatggatgat gtttgactac tggggccaag gaaccctggt caccgtctcg     1500

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     1560

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg     1620

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     1680

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     1740

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag     1800

cccaaatctt gtgac                                                      1815


<210>  217
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  217

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  218
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  218
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggataaga aagttgagcc caaatcttgt      660

gactccggcg gaggagggag cggcggaggt ggctccggag gtggcggagc acctgcctca      720

agttctacaa agaaaacaca gctacaactg gagcatttac tgctggattt acagatgatt      780

ttgaatggaa ttaataatta caagaatccc aaactcacca ggatgctcac agccaagttt      840

gccatgccca agaaggccac agaactgaaa catcttcagt gtctagaaga agaactcaaa      900

cctctggagg aagtgctaaa tggcgctcaa agcaaaaact ttcacttaag acccagggac      960

ttaatcagca atatcaacgt aatagttctg gaactaaagg gatctgaaac aacattcatg     1020

tgtgaatatg ctgatgagac agcaaccatt gtagaatttc tgaacagatg gattaccttt     1080

gcccaaagca tcatctcaac actgacttcc ggcggaggag gatccggcgg aggtggctct     1140

ggcggtggcg gagaggtgca attgttggag tctgggggag gcttggtaca gcctgggggg     1200

tccctgagac tctcctgtgc agcctccgga ttcaccttta gcagttatgc catgagctgg     1260

gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtgg tagtggtggt     1320

agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga caattccaag     1380

aacacgctgt atctgcagat gaacagcctg agagccgagg acacggccgt atattactgt     1440

gcgaaagggt ggctgggtaa ttttgactac tggggccaag gaaccctggt caccgtctcg     1500

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     1560

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg     1620

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     1680

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     1740

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag     1800

cccaaatctt gtgac                                                      1815


<210>  219
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  219

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser Ser 
225                 230                 235                 240 


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
                245                 250                 255     


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
            260                 265                 270         


Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu Leu 
        275                 280                 285             


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
    290                 295                 300                 


Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
305                 310                 315                 320 


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
                325                 330                 335     


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
            340                 345                 350         


Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu Thr 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu 
    370                 375                 380                 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
385                 390                 395                 400 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Ala 
                405                 410                 415     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            420                 425                 430         


Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly 
        435                 440                 445             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    450                 455                 460                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
465                 470                 475                 480 


Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
            500                 505                 510         


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
        515                 520                 525             


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
    530                 535                 540                 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
545                 550                 555                 560 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
                565                 570                 575     


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
            580                 585                 590         


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600             


<210>  220
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28H1 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  220
gaagtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc tcccacgcca tgtcctgggt ccgacaggct      120

cctggcaaag gcctggaatg ggtgtccgcc atctgggcct ccggcgagca gtactacgcc      180

gactctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgtgccaa gggctggctg      300

ggcaacttcg actactgggg acagggcacc ctggtcaccg tgtccagcgc tagcaccaag      360

ggaccctccg tgttccccct ggccccctcc agcaagtcta cctctggcgg caccgccgct      420

ctgggctgcc tggtcaagga ctacttcccc gagcccgtga ccgtgtcctg gaactctggc      480

gccctgacca gcggcgtcca cacctttcca gccgtgctgc agtcctccgg cctgtactcc      540

ctgtcctccg tcgtgaccgt gccctccagc tctctgggca cccagaccta catctgcaac      600

gtgaaccaca agccctccaa caccaaggtg gacaagaagg tggaacccaa gtcctgcgac      660

agtggtgggg gaggatctgg tggcggaggt tctggcggag gtggcgctcc tgcctcctcc      720

agcaccaaga aaacccagct ccagctggaa catctcctgc tggatctgca gatgatcctg      780

aacggcatca acaactacaa gaaccccaag ctgacccgga tgctgaccgc caagttcgcc      840

atgcccaaga aggccaccga gctgaaacat ctgcagtgcc tggaagagga actgaagcct      900

ctggaagagg tgctgaacgg cgcccagtcc aagaacttcc acctgaggcc tcgggacctg      960

atctccaaca tcaacgtgat cgtgctggaa ctgaagggct ccgagacaac cttcatgtgc     1020

gagtacgccg acgagacagc taccatcgtg gaatttctga accggtggat caccttcgcc     1080

cagtccatca tctccaccct gacctccggt ggtggcggat ccgggggagg gggttctggc     1140

ggaggcggag aagtgcagct gctggaatcc ggcggaggcc tggtgcagcc tggcggatct     1200

ctgagactgt cctgcgccgc ctccggcttc accttctcct cccacgccat gtcctgggtc     1260

cgacaggctc caggcaaggg cctggaatgg gtgtccgcca tctgggcctc cggcgagcag     1320

tactacgccg actctgtgaa gggccggttc accatctccc gggacaactc caagaacacc     1380

ctgtacctgc agatgaactc cctgcgggcc gaggacaccg ccgtgtacta ctgtgccaag     1440

ggctggctgg gcaacttcga ctactggggc cagggcaccc tggtcaccgt gtcctccgcc     1500

tctaccaagg gcccctccgt gttccctctg gccccctcca gcaagtctac ctctggcggc     1560

accgccgctc tgggctgcct ggtcaaggac tacttccccg agcccgtgac cgtgtcctgg     1620

aactctggcg ccctgaccag cggcgtgcac acctttccag ccgtgctgca gtcctccggc     1680

ctgtactccc tgtcctccgt cgtgaccgtg ccctccagct ctctgggcac ccagacctac     1740

atctgcaacg tgaaccacaa gccctccaac accaaggtgg acaagaaggt ggaacccaag     1800

tcctgcgac                                                             1809


<210>  221
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29B11 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  221

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  222
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29B11 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  222
gaagtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc tcctacgcca tgtcctgggt ccgacaggct      120

cctggcaaag gcctggaatg ggtgtccgcc atcatcggct ccggcggcat cacctactac      180

gccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc caagggctgg      300

ttcggaggct tcaactactg gggacagggc accctggtca ccgtgtccag cgctagcacc      360

aagggaccct ccgtgttccc cctggccccc tccagcaagt ctacctctgg cggcaccgcc      420

gctctgggct gcctggtcaa ggactacttc cccgagcccg tgaccgtgtc ctggaactct      480

ggcgccctga ccagcggcgt ccacaccttt ccagccgtgc tgcagtcctc cggcctgtac      540

tccctgtcct ccgtcgtgac cgtgccctcc agctctctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagccctc caacaccaag gtggacaaga aggtggaacc caagtcctgc      660

gacagtggtg ggggaggatc tggtggcgga ggttctggcg gaggtggcgc tcctgcctcc      720

tccagcacca agaaaaccca gctccagctg gaacatctcc tgctggatct gcagatgatc      780

ctgaacggca tcaacaacta caagaacccc aagctgaccc ggatgctgac cgccaagttc      840

gccatgccca agaaggccac cgagctgaaa catctgcagt gcctggaaga ggaactgaag      900

cctctggaag aggtgctgaa cggcgcccag tccaagaact tccacctgag gcctcgggac      960

ctgatctcca acatcaacgt gatcgtgctg gaactgaagg gctccgagac aaccttcatg     1020

tgcgagtacg ccgacgagac agctaccatc gtggaatttc tgaaccggtg gatcaccttc     1080

gcccagtcca tcatctccac cctgacctcc ggtggtggcg gatccggggg agggggttct     1140

ggcggaggcg gagaagtgca gctgctggaa tccggcggag gcctggtgca gcctggcgga     1200

tctctgagac tgtcctgcgc cgcctccggc ttcaccttct cctcctatgc catgtcctgg     1260

gtccgacagg ctccaggcaa gggcctggaa tgggtgtccg ccatcatcgg ctccggcggc     1320

atcacctact acgccgactc tgtgaagggc cggttcacca tctcccggga caactccaag     1380

aacaccctgt acctgcagat gaactccctg cgggccgagg acaccgccgt gtactactgt     1440

gccaagggct ggttcggagg cttcaactac tggggccagg gcaccctggt caccgtgtcc     1500

tccgcctcta ccaagggccc ctccgtgttc cctctggccc cctccagcaa gtctacctct     1560

ggcggcaccg ccgctctggg ctgcctggtc aaggactact tccccgagcc cgtgaccgtg     1620

tcctggaact ctggcgccct gaccagcggc gtgcacacct ttccagccgt gctgcagtcc     1680

tccggcctgt actccctgtc ctccgtcgtg accgtgccct ccagctctct gggcacccag     1740

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggaa     1800

cccaagtcct gcgac                                                      1815


<210>  223
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19G1 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  223

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Ser Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ile Ser Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  224
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  19G1 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  224
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcatcagct ctggcggcct gacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggaccca gcgtgttccc cctggccccc agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctggtcaa agactacttc cccgagcccg tgaccgtgtc ctggaacagc      480

ggagccctga ccagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtcac cgtgcctagc tctagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gactccggcg gaggcggatc tggcggtgga ggctccggag gcggaggcgc tcctgccagc      720

agctccacca agaaaaccca gctccagctg gaacatctgc tgctggatct gcagatgatc      780

ctgaacggca tcaacaacta caagaacccc aagctgaccc ggatgctgac cgccaagttc      840

gccatgccca agaaggccac cgaactgaaa catctgcagt gcctggaaga ggaactgaag      900

cctctggaag aggtgctgaa cggcgcccag agcaagaact tccacctgag gcccagggac      960

ctgatcagca acatcaacgt gatcgtgctg gaactgaagg gcagcgagac aaccttcatg     1020

tgcgagtacg ccgacgagac agccaccatc gtggaatttc tgaaccggtg gatcaccttc     1080

gcccagagca tcatcagcac cctgacaagc ggaggcggcg gatccggcgg aggcggatct     1140

ggcggaggag gcgaggtcca gctgctcgaa agcggcggag gactggtgca gcctggcggc     1200

agcctgagac tgtcttgcgc cgccagcggc ttcaccttca gcagctacgc catgagctgg     1260

gtccgccagg cccctggcaa gggactggaa tgggtgtccg ccatcatcag ctctggcggc     1320

ctgacctact acgccgacag cgtgaagggc cggttcacca tcagccggga caacagcaag     1380

aacaccctgt acctgcagat gaacagcctg cgggccgagg acaccgccgt gtactactgc     1440

gccaagggat ggttcggcgg cttcaactac tggggacagg gcaccctggt cacagtgtcc     1500

agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcacatct     1560

ggcggaacag ccgccctggg ctgcctggtc aaagactact tccccgagcc cgtgaccgtg     1620

tcctggaaca gcggagccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc     1680

agcggcctgt acagcctgag cagcgtggtc accgtgccta gctctagcct gggcacccag     1740

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa     1800

cccaagagct gcgac                                                      1815


<210>  225
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G8 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  225

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ile Gly Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  226
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20G8 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  226
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcatcggct ctggcagccg gacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggaccca gcgtgttccc cctggccccc agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctggtcaa agactacttc cccgagcccg tgaccgtgtc ctggaacagc      480

ggagccctga ccagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtcac cgtgcctagc tctagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gactccggcg gaggcggatc tggcggtgga ggctccggag gcggaggcgc tcctgccagc      720

agctccacca agaaaaccca gctccagctg gaacatctgc tgctggatct gcagatgatc      780

ctgaacggca tcaacaacta caagaacccc aagctgaccc ggatgctgac cgccaagttc      840

gccatgccca agaaggccac cgaactgaaa catctgcagt gcctggaaga ggaactgaag      900

cctctggaag aggtgctgaa cggcgcccag agcaagaact tccacctgag gcccagggac      960

ctgatcagca acatcaacgt gatcgtgctg gaactgaagg gcagcgagac aaccttcatg     1020

tgcgagtacg ccgacgagac agccaccatc gtggaatttc tgaaccggtg gatcaccttc     1080

gcccagagca tcatcagcac cctgacaagc ggaggcggcg gatccggcgg aggcggatct     1140

ggcggaggag gcgaggtcca gctgctcgaa agcggcggag gactggtgca gcctggcggc     1200

agcctgagac tgtcttgcgc cgccagcggc ttcaccttca gcagctacgc catgagctgg     1260

gtccgccagg cccctggcaa gggactggaa tgggtgtccg ccatcatcgg ctctggcagc     1320

cggacctact acgccgacag cgtgaagggc cggttcacca tcagccggga caacagcaag     1380

aacaccctgt acctgcagat gaacagcctg cgggccgagg acaccgccgt gtactactgc     1440

gccaagggat ggttcggcgg cttcaactac tggggacagg gcaccctggt cacagtgtcc     1500

agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcacatct     1560

ggcggaacag ccgccctggg ctgcctggtc aaagactact tccccgagcc cgtgaccgtg     1620

tcctggaaca gcggagccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc     1680

agcggcctgt acagcctgag cagcgtggtc accgtgccta gctctagcct gggcacccag     1740

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa     1800

cccaagagct gcgac                                                      1815


<210>  227
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B9 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  227

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  228
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B9 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  228
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcatcggct ctggcgccag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggaccca gcgtgttccc cctggccccc agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctggtcaa agactacttc cccgagcccg tgaccgtgtc ctggaacagc      480

ggagccctga ccagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtcac cgtgcctagc tctagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gactccggcg gaggcggatc tggcggtgga ggctccggag gcggaggcgc tcctgccagc      720

agctccacca agaaaaccca gctccagctg gaacatctgc tgctggatct gcagatgatc      780

ctgaacggca tcaacaacta caagaacccc aagctgaccc ggatgctgac cgccaagttc      840

gccatgccca agaaggccac cgaactgaaa catctgcagt gcctggaaga ggaactgaag      900

cctctggaag aggtgctgaa cggcgcccag agcaagaact tccacctgag gcccagggac      960

ctgatcagca acatcaacgt gatcgtgctg gaactgaagg gcagcgagac aaccttcatg     1020

tgcgagtacg ccgacgagac agccaccatc gtggaatttc tgaaccggtg gatcaccttc     1080

gcccagagca tcatcagcac cctgacaagc ggaggcggcg gatccggcgg aggcggatct     1140

ggcggaggag gcgaggtcca gctgctcgaa agcggcggag gactggtgca gcctggcggc     1200

agcctgagac tgtcttgcgc cgccagcggc ttcaccttca gcagctacgc catgagctgg     1260

gtccgccagg cccctggcaa gggactggaa tgggtgtccg ccatcatcgg ctctggcgcc     1320

agcacctact acgccgacag cgtgaagggc cggttcacca tcagccggga caacagcaag     1380

aacaccctgt acctgcagat gaacagcctg cgggccgagg acaccgccgt gtactactgc     1440

gccaagggat ggttcggcgg cttcaactac tggggacagg gcaccctggt cacagtgtcc     1500

agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcacatct     1560

ggcggaacag ccgccctggg ctgcctggtc aaagactact tccccgagcc cgtgaccgtg     1620

tcctggaaca gcggagccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc     1680

agcggcctgt acagcctgag cagcgtggtc accgtgccta gctctagcct gggcacccag     1740

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa     1800

cccaagagct gcgac                                                      1815


<210>  229
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14B3 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  229

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Gly Ala Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                245                 250                 255     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            260                 265                 270         


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
        275                 280                 285             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    290                 295                 300                 


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                325                 330                 335     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            340                 345                 350         


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
        355                 360                 365             


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Leu Ala Ser Gly Ala Ile Thr Tyr Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            500                 505                 510         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        515                 520                 525             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    530                 535                 540                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
545                 550                 555                 560 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                565                 570                 575     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            580                 585                 590         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
        595                 600                 605 


<210>  230
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14B3 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  230
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcctggcct ctggcgccat cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggaccca gcgtgttccc cctggccccc agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctggtcaa agactacttc cccgagcccg tgaccgtgtc ctggaacagc      480

ggagccctga ccagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtcac cgtgcctagc tctagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gactccggcg gaggcggatc tggcggtgga ggctccggag gcggaggcgc tcctgccagc      720

agctccacca agaaaaccca gctccagctg gaacatctgc tgctggatct gcagatgatc      780

ctgaacggca tcaacaacta caagaacccc aagctgaccc ggatgctgac cgccaagttc      840

gccatgccca agaaggccac cgaactgaaa catctgcagt gcctggaaga ggaactgaag      900

cctctggaag aggtgctgaa cggcgcccag agcaagaact tccacctgag gcccagggac      960

ctgatcagca acatcaacgt gatcgtgctg gaactgaagg gcagcgagac aaccttcatg     1020

tgcgagtacg ccgacgagac agccaccatc gtggaatttc tgaaccggtg gatcaccttc     1080

gcccagagca tcatcagcac cctgacaagc ggaggcggcg gatccggcgg aggcggatct     1140

ggcggaggag gcgaggtcca gctgctcgaa agcggcggag gactggtgca gcctggcggc     1200

agcctgagac tgtcttgcgc cgccagcggc ttcaccttca gcagctacgc catgagctgg     1260

gtccgccagg cccctggcaa gggactggaa tgggtgtccg ccatcctggc ctctggcgcc     1320

atcacctact acgccgacag cgtgaagggc cggttcacca tcagccggga caacagcaag     1380

aacaccctgt acctgcagat gaacagcctg cgggccgagg acaccgccgt gtactactgc     1440

gccaagggat ggttcggcgg cttcaactac tggggacagg gcaccctggt cacagtgtcc     1500

agcgccagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcacatct     1560

ggcggaacag ccgccctggg ctgcctggtc aaagactact tccccgagcc cgtgaccgtg     1620

tcctggaaca gcggagccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc     1680

agcggcctgt acagcctgag cagcgtggtc accgtgccta gctctagcct gggcacccag     1740

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa     1800

cccaagagct gcgac                                                      1815


<210>  231
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 light chain

<400>  231

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  232
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 light chain

<400>  232
gagatcgtgc tgacccagtc ccccggcacc ctgtctctga gccctggcga gagagccacc       60

ctgtcctgca gagcctccca gtccgtgacc tcctcctacc tcgcctggta tcagcagaag      120

cccggccagg cccctcggct gctgatcaac gtgggcagtc ggagagccac cggcatccct      180

gaccggttct ccggctctgg ctccggcacc gacttcaccc tgaccatctc ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggcatca tgctgccccc cacctttggc      300

cagggcacca aggtggaaat caagcgtacg gtggccgctc cctccgtgtt catcttccca      360

ccctccgacg agcagctgaa gtccggcacc gcctccgtcg tgtgcctgct gaacaacttc      420

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagtc cggcaactcc      480

caggaatccg tcaccgagca ggactccaag gacagcacct actccctgtc ctccaccctg      540

accctgtcca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag      600

ggcctgtcca gccccgtgac caagtccttc aaccggggcg agtgc                      645


<210>  233
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8 light chain

<400>  233

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  234
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8 light chain

<400>  234
gagatcgtgc tgacccagtc ccccggcacc ctgtctctga gccctggcga gagagccacc       60

ctgtcctgca gagcctccca gtccgtgtcc cggtcctacc tcgcctggta tcagcagaag      120

cccggccagg cccctcggct gctgatcatc ggcgcctcta ccagagccac cggcatccct      180

gaccggttct ccggctctgg ctccggcacc gacttcaccc tgaccatctc ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggccagg tcatccctcc cacctttggc      300

cagggcacca aggtggaaat caagcgtacg gtggccgctc cctccgtgtt catcttccca      360

ccctccgacg agcagctgaa gtccggcacc gcctccgtcg tgtgcctgct gaacaacttc      420

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagtc cggcaactcc      480

caggaatccg tcaccgagca ggactccaag gacagcacct actccctgtc ctccaccctg      540

accctgtcca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag      600

ggcctgtcca gccccgtgac caagtccttc aaccggggcg agtgc                      645


<210>  235
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9 light chain

<400>  235

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Leu Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  236
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9 light chain

<400>  236
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  237
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F11 light chain

<400>  237

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Tyr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  238
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F11 light chain

<400>  238
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagt atactccccc cacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  239
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3 light chain

<400>  239

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Tyr Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  240
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3 light chain

<400>  240
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcaattact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcgcctaca tcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  241
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  241

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        355                 360                 365             


Ile Ser Thr Leu Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
385                 390                 395                 400 


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr 
                405                 410                 415     


Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
            420                 425                 430         


Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr 
        435                 440                 445             


Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
    450                 455                 460                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
465                 470                 475                 480 


Val Tyr Tyr Cys Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe 
                485                 490                 495     


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
            500                 505                 510         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        515                 520                 525             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    530                 535                 540                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
545                 550                 555                 560 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                565                 570                 575     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            580                 585                 590         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        595                 600                 605             


Pro Lys Ser Cys Asp 
    610             


<210>  242
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  242
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag      660

cccaaatctt gtgactccgg cggaggaggg agcggcggag gtggctccgg aggtggcgga      720

gcacctgcct caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      780

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      840

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      900

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      960

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa     1020

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga     1080

tggattacct ttgcccaaag catcatctca acactgactt ccggcggagg aggatccggc     1140

ggaggtggct ctggcggtgg cggacaggtg caattggtgc agtctggggc tgaggtgaag     1200

aagcctgggt cctcggtgaa ggtctcctgc aaggcctccg gaggcacatt cagcagctac     1260

gctataagct gggtgcgaca ggcccctgga caagggctcg agtggatggg agggatcatc     1320

cctatctttg gtacagcaaa ctacgcacag aagttccagg gcagggtcac cattactgca     1380

gacaaatcca cgagcacagc ctacatggag ctgagcagcc tgagatctga ggacaccgcc     1440

gtgtattact gtgcgagact gtacggttac gcttactacg gtgcttttga ctactggggc     1500

caagggacca ccgtgaccgt ctcctcagct agcaccaagg gcccatcggt cttccccctg     1560

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac     1620

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac     1680

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg     1740

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac     1800

accaaggtgg ataagaaagt tgagcccaaa tcttgtgac                            1839


<210>  243
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3B6 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  243

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        355                 360                 365             


Ile Ser Thr Leu Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
385                 390                 395                 400 


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr 
                405                 410                 415     


Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
            420                 425                 430         


Leu Glu Trp Met Gly Ala Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr 
        435                 440                 445             


Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
    450                 455                 460                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
465                 470                 475                 480 


Val Tyr Tyr Cys Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe 
                485                 490                 495     


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
            500                 505                 510         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        515                 520                 525             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    530                 535                 540                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
545                 550                 555                 560 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                565                 570                 575     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            580                 585                 590         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        595                 600                 605             


Pro Lys Ser Cys Asp 
    610             


<210>  244
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C3B6 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  244
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggagct atcatcccga tccttggtat cgcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag      660

cccaaatctt gtgactccgg cggaggaggg agcggcggag gtggctccgg aggtggcgga      720

gcacctgcct caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      780

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      840

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      900

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      960

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa     1020

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga     1080

tggattacct ttgcccaaag catcatctca acactgactt ccggcggagg aggatccggc     1140

ggaggtggct ctggcggtgg cggacaggtg caattggtgc agtctggggc tgaggtgaag     1200

aagcctgggt cctcggtgaa ggtctcctgc aaggcctccg gaggcacatt cagcagctac     1260

gctataagct gggtgcgaca ggcccctgga caagggctcg agtggatggg agctatcatc     1320

ccgatccttg gtatcgcaaa ctacgcacag aagttccagg gcagggtcac cattactgca     1380

gacaaatcca cgagcacagc ctacatggag ctgagcagcc tgagatctga ggacaccgcc     1440

gtgtattact gtgcgagact gtacggttac gcttactacg gtgcttttga ctactggggc     1500

caagggacca ccgtgaccgt ctcctcagct agcaccaagg gcccatcggt cttccccctg     1560

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac     1620

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac     1680

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg     1740

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac     1800

accaaggtgg ataagaaagt tgagcccaaa tcttgtgac                            1839


<210>  245
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  245

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile 
        355                 360                 365             


Ile Ser Thr Leu Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
385                 390                 395                 400 


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr 
                405                 410                 415     


Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
            420                 425                 430         


Leu Glu Trp Met Gly Val Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr 
        435                 440                 445             


Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
    450                 455                 460                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
465                 470                 475                 480 


Val Tyr Tyr Cys Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe 
                485                 490                 495     


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
            500                 505                 510         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        515                 520                 525             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    530                 535                 540                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
545                 550                 555                 560 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                565                 570                 575     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            580                 585                 590         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        595                 600                 605             


Pro Lys Ser Cys Asp 
    610             


<210>  246
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6A12 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  246
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctatgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggagtg atcatcccta tccttggtac cgcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaagttgag      660

cccaaatctt gtgactccgg cggaggaggg agcggcggag gtggctccgg aggtggcgga      720

gcacctgcct caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      780

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      840

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      900

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      960

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa     1020

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga     1080

tggattacct ttgcccaaag catcatctca acactgactt ccggcggagg aggatccggc     1140

ggaggtggct ctggcggtgg cggacaggtg caattggtgc agtctggggc tgaggtgaag     1200

aagcctgggt cctcggtgaa ggtctcctgc aaggcctccg gaggcacatt cagcagctat     1260

gctataagct gggtgcgaca ggcccctgga caagggctcg agtggatggg agtgatcatc     1320

cctatccttg gtaccgcaaa ctacgcacag aagttccagg gcagggtcac cattactgca     1380

gacaaatcca cgagcacagc ctacatggag ctgagcagcc tgagatctga ggacaccgcc     1440

gtgtattact gtgcgagact gtacggttac gcttactacg gtgcttttga ctactggggc     1500

caagggacca ccgtgaccgt ctcctcagct agcaccaagg gcccatcggt cttccccctg     1560

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac     1620

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac     1680

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg     1740

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac     1800

accaaggtgg ataagaaagt tgagcccaaa tcttgtgac                            1839


<210>  247
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10 light chain

<400>  247

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  248
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10 light chain

<400>  248
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  249
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1A2 light chain

<400>  249

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  250
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1A2 light chain

<400>  250
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca ggggattcgt aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gcttacagct tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  251
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O7D8 light chain

<400>  251

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  252
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O7D8 light chain

<400>  252
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gagcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gtgtccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  253
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHLG1 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  253

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Thr Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly 
        435                 440                 445             


Arg Tyr Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Thr Thr Tyr Gly Asn Tyr Val Gly His 
                485                 490                 495     


Tyr Phe Asp His Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            500                 505                 510         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        515                 520                 525             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    530                 535                 540                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
545                 550                 555                 560 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                565                 570                 575     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            580                 585                 590         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        595                 600                 605             


Val Glu Pro Lys Ser Cys Asp 
    610                 615 


<210>  254
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHLG1 Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  254
gaagtgcagc tggtggagtc tggaggaggc ttggtcaagc ctggcgggtc cctgcggctc       60

tcctgtgcag cctccggatt cacatttagc aactattgga tgaactgggt gcggcaggct      120

cctggaaagg gcctcgagtg ggtggccgag atcagattga aatccaataa cttcggaaga      180

tattacgctg caagcgtgaa gggccggttc accatcagca gagatgattc caagaacacg      240

ctgtacctgc agatgaacag cctgaagacc gaggatacgg ccgtgtatta ctgtaccaca      300

tacggcaact acgttgggca ctacttcgac cactggggcc aagggaccac cgtcaccgtc      360

tccagtgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga taagaaagtt      660

gagcccaaat cttgtgactc cggcggagga gggagcggcg gaggtggctc cggaggtggc      720

ggagcacctg cctcaagttc tacaaagaaa acacagctac aactggagca tttactgctg      780

gatttacaga tgattttgaa tggaattaat aattacaaga atcccaaact caccaggatg      840

ctcacagcca agtttgccat gcccaagaag gccacagaac tgaaacatct tcagtgtcta      900

gaagaagaac tcaaacctct ggaggaagtg ctaaatggcg ctcaaagcaa aaactttcac      960

ttaagaccca gggacttaat cagcaatatc aacgtaatag ttctggaact aaagggatct     1020

gaaacaacat tcatgtgtga atatgctgat gagacagcaa ccattgtaga atttctgaac     1080

agatggatta cctttgccca aagcatcatc tcaacactga cttccggcgg aggaggatcc     1140

ggcggaggtg gctctggcgg tggcggagaa gtgcagctgg tggagtctgg aggaggcttg     1200

gtcaagcctg gcgggtccct gcggctctcc tgtgcagcct ccggattcac atttagcaac     1260

tattggatga actgggtgcg gcaggctcct ggaaagggcc tcgagtgggt ggccgagatc     1320

agattgaaat ccaataactt cggaagatat tacgctgcaa gcgtgaaggg ccggttcacc     1380

atcagcagag atgattccaa gaacacgctg tacctgcaga tgaacagcct gaagaccgag     1440

gatacggccg tgtattactg taccacatac ggcaactacg ttgggcacta cttcgaccac     1500

tggggccaag ggaccaccgt caccgtctcc agtgctagca ccaagggccc atcggtcttc     1560

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc     1620

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc     1680

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg     1740

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc     1800

agcaacacca aggtggataa gaaagttgag cccaaatctt gtgac                     1845


<210>  255
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KV9 light chain

<400>  255

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  256
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KV9 light chain

<400>  256
gatatccagt tgacccagtc tccatccttc ctgtctgcat ctgtgggcga ccgggtcacc       60

atcacctgca aggccagtca gaatgtggat actaacgtgg cttggtacca gcagaagcca      120

gggcaggcac ctaggcctct gatctattcg gcatcctacc ggtacactgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca caatctcaag cctgcaacct      240

gaagatttcg caacttacta ctgtcaacag tacaatagtt accctctgac gttcggcgga      300

ggtaccaagg tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  257
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHLG Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  257

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Thr Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly 
        435                 440                 445             


Arg Tyr Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Thr Thr Tyr Gly Asn Tyr Val Gly His 
                485                 490                 495     


Tyr Phe Asp His Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            500                 505                 510         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        515                 520                 525             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    530                 535                 540                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
545                 550                 555                 560 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                565                 570                 575     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            580                 585                 590         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        595                 600                 605             


Val Glu Pro Lys Ser Cys Asp 
    610                 615 


<210>  258
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHLG Fab-IL2 qm-Fab (heavy chain cytokine fusion construct)

<400>  258
gaagtgcagc tggtggagtc tggaggaggc ttggtccagc ctggcgggtc cctgcggctc       60

tcctgtgcag cctccggatt cacatttagc aactattgga tgaactgggt gcggcaggct      120

cctggaaagg gcctcgagtg ggtggccgag atcagattga aatccaataa cttcggaaga      180

tattacgctg caagcgtgaa gggccggttc accatcagca gagatgattc caagaacacg      240

ctgtacctgc agatgaacag cctgaagacc gaggatacgg ccgtgtatta ctgtaccaca      300

tacggcaact acgttgggca ctacttcgac cactggggcc aagggaccac cgtcaccgtc      360

tccagtgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga taagaaagtt      660

gagcccaaat cttgtgactc cggcggagga gggagcggcg gaggtggctc cggaggtggc      720

ggagcacctg cctcaagttc tacaaagaaa acacagctac aactggagca tttactgctg      780

gatttacaga tgattttgaa tggaattaat aattacaaga atcccaaact caccaggatg      840

ctcacagcca agtttgccat gcccaagaag gccacagaac tgaaacatct tcagtgtcta      900

gaagaagaac tcaaacctct ggaggaagtg ctaaatggcg ctcaaagcaa aaactttcac      960

ttaagaccca gggacttaat cagcaatatc aacgtaatag ttctggaact aaagggatct     1020

gaaacaacat tcatgtgtga atatgctgat gagacagcaa ccattgtaga atttctgaac     1080

agatggatta cctttgccca aagcatcatc tcaacactga cttccggcgg aggaggatcc     1140

ggcggaggtg gctctggcgg tggcggagaa gtgcagctgg tggagtctgg aggaggcttg     1200

gtccagcctg gcgggtccct gcggctctcc tgtgcagcct ccggattcac atttagcaac     1260

tattggatga actgggtgcg gcaggctcct ggaaagggcc tcgagtgggt ggccgagatc     1320

agattgaaat ccaataactt cggaagatat tacgctgcaa gcgtgaaggg ccggttcacc     1380

atcagcagag atgattccaa gaacacgctg tacctgcaga tgaacagcct gaagaccgag     1440

gatacggccg tgtattactg taccacatac ggcaactacg ttgggcacta cttcgaccac     1500

tggggccaag ggaccaccgt caccgtctcc agtgctagca ccaagggccc atcggtcttc     1560

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc     1620

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc     1680

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg     1740

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc     1800

agcaacacca aggtggataa gaaagttgag cccaaatctt gtgac                     1845


<210>  259
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KV1 light chain

<400>  259

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  260
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KV1 light chain

<400>  260
gatatccagt tgacccagtc tccatccttc ctgtctgcat ctgtgggcga ccgggtcacc       60

atcacctgca gggccagtca gaatgtggat actaacttag cttggtacca gcagaagcca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gttacactgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca caatctcaag cctgcaacct      240

gaagatttcg caacttacta ctgtcaacag tacaatagtt accctctgac gttcggcgga      300

ggtaccaagg tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  261
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KV7 light chain

<400>  261

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  262
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KV7 light chain

<400>  262
gatatccagt tgacccagtc tccatccttc ctgtctgcat ctgtgggcga ccgggtcacc       60

atcacctgca aggccagtca gaatgtggat actaacgtgg cttggtacca gcagaagcca      120

gggaaagcac ctaagcctct gatctattcg gcatcctacc ggtacactgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca caatctcaag cctgcaacct      240

gaagatttcg caacttacta ctgtcaacag tacaatagtt accctctgac gttcggcgga      300

ggtaccaagg tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  263
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  263

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  264
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  264
atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  265
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  265
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  266
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  266

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys 
            20          


<210>  267
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  267
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgt                                                                  66


<210>  268
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  268

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  269
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  269
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcc          57


<210>  270
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  270
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc          57


<210>  271
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  271
atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct          57


<210>  272
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  272

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  273
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  273
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60


<210>  274
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2R-beta-Fc(hole) fusion protein

<400>  274

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys Ala Val Asn Gly Thr Ser Gln Phe Thr Cys 
            20                  25                  30          


Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly 
        35                  40                  45              


Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg 
    50                  55                  60                  


Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp 
65                  70                  75                  80  


Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr 
                85                  90                  95      


Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp 
            100                 105                 110         


Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu 
        115                 120                 125             


Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys 
    130                 135                 140                 


Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His 
145                 150                 155                 160 


Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu 
                165                 170                 175     


Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu 
            180                 185                 190         


Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro 
        195                 200                 205             


Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala 
    210                 215                 220                 


Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr Gly Ala Gln Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  275
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-2R-beta-Fc(hole) fusion protein

<400>  275
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgtgcgg tgaatggcac ttcccagttc acatgcttct acaactcgag agccaacatc      120

tcctgtgtct ggagccaaga tggggctctg caggacactt cctgccaagt ccatgcctgg      180

ccggacagac ggcggtggaa ccaaacctgt gagctgctcc ccgtgagtca agcatcctgg      240

gcctgcaacc tgatcctcgg agccccagat tctcagaaac tgaccacagt tgacatcgtc      300

accctgaggg tgctgtgccg tgagggggtg cgatggaggg tgatggccat ccaggacttc      360

aagccctttg agaaccttcg cctgatggcc cccatctccc tccaagttgt ccacgtggag      420

acccacagat gcaacataag ctgggaaatc tcccaagcct cccactactt tgaaagacac      480

ctggagttcg aggcccggac gctgtcccca ggccacacct gggaggaggc ccccctgctg      540

actctcaagc agaagcagga atggatctgc ctggagacgc tcaccccaga cacccagtat      600

gagtttcagg tgcgggtcaa gcctctgcaa ggcgagttca cgacctggag cccctggagc      660

cagcccctgg ccttcagaac aaagcctgca gcccttggga aggacaccgg agctcaggac      720

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080

cagccccgag aaccacaggt gtgcaccctg cccccatccc gggatgagct gaccaagaac     1140

caggtcagcc tctcgtgcgc agtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc cgggtaaatg a                                               1401


<210>  276
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2R-gamma-Fc(knob) fusion protein

<400>  276

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Gly Ala Gln Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
385                 390                 395                 400 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490         


<210>  277
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-2R-gamma-Fc(knob) fusion protein

<400>  277
atgttgaagc catcattacc attcacatcc ctcttattcc tgcagctgcc cctgctggga       60

gtggggctga acacgacaat tctgacgccc aatgggaatg aagacaccac agctgatttc      120

ttcctgacca ctatgcccac tgactccctc agtgtttcca ctctgcccct cccagaggtt      180

cagtgttttg tgttcaatgt cgagtacatg aattgcactt ggaacagcag ctctgagccc      240

cagcctacca acctcactct gcattattgg tacaagaact cggataatga taaagtccag      300

aagtgcagcc actatctatt ctctgaagaa atcacttctg gctgtcagtt gcaaaaaaag      360

gagatccacc tctaccaaac atttgttgtt cagctccagg acccacggga acccaggaga      420

caggccacac agatgctaaa actgcagaat ctggtgatcc cctgggctcc agagaaccta      480

acacttcaca aactgagtga atcccagcta gaactgaact ggaacaacag attcttgaac      540

cactgtttgg agcacttggt gcagtaccgg actgactggg accacagctg gactgaacaa      600

tcagtggatt atagacataa gttctccttg cctagtgtgg atgggcagaa acgctacacg      660

tttcgtgttc ggagccgctt taacccactc tgtggaagtg ctcagcattg gagtgaatgg      720

agccacccaa tccactgggg gagcaatact tcaaaagaga atcctttcct gtttgcattg      780

gaagccggag ctcaggacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      840

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      900

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      960

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1020

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1080

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1140

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatgccgg     1200

gatgagctga ccaagaacca ggtcagcctg tggtgcctgg tcaaaggctt ctatcccagc     1260

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1320

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1380

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1440

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1479


<210>  278
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2R alpha subunit + Avi-tag + His-tag

<400>  278

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
            20                  25                  30          


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
        35                  40                  45              


Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu 
    50                  55                  60                  


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
65                  70                  75                  80  


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
                85                  90                  95      


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
            100                 105                 110         


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
        115                 120                 125             


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
    130                 135                 140                 


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
145                 150                 155                 160 


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
                165                 170                 175     


Gln Pro Gln Leu Ile Cys Thr Gly Val Asp Glu Gln Leu Tyr Phe Gln 
            180                 185                 190         


Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
        195                 200                 205             


His Glu Ala Arg Ala His His His His His His 
    210                 215                 


<210>  279
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-2R alpha subunit + Avi-tag + His-tag

<400>  279
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

ctctgtgacg atgacccgcc agagatccca cacgccacat tcaaagccat ggcctacaag      120

gaaggaacca tgttgaactg tgaatgcaag agaggtttcc gcagaataaa aagcgggtca      180

ctctatatgc tctgtacagg aaactctagc cactcgtcct gggacaacca atgtcaatgc      240

acaagctctg ccactcggaa cacaacgaaa caagtgacac ctcaacctga agaacagaaa      300

gaaaggaaaa ccacagaaat gcaaagtcca atgcagccag tggaccaagc gagccttcca      360

ggtcactgca gggaacctcc accatgggaa aatgaagcca cagagagaat ttatcatttc      420

gtggtggggc agatggttta ttatcagtgc gtccagggat acagggctct acacagaggt      480

cctgctgaga gcgtctgcaa aatgacccac gggaagacaa ggtggaccca gccccagctc      540

atatgcacag gtgtcgacga acagttatat tttcagggcg gctcaggcct gaacgacatc      600

ttcgaggccc agaagatcga gtggcacgag gctcgagctc accaccatca ccatcactga      660


<210>  280
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine IL-2R-beta-Fc(hole) fusion protein

<400>  280

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Leu Leu Leu Leu Trp Phe Pro Gly Ala Arg Cys Ala Val Lys 
            20                  25                  30          


Asn Cys Ser His Leu Glu Cys Phe Tyr Asn Ser Arg Ala Asn Val Ser 
        35                  40                  45              


Cys Met Trp Ser His Glu Glu Ala Leu Asn Val Thr Thr Cys His Val 
    50                  55                  60                  


His Ala Lys Ser Asn Leu Arg His Trp Asn Lys Thr Cys Glu Leu Thr 
65                  70                  75                  80  


Leu Val Arg Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ser Phe 
                85                  90                  95      


Pro Glu Ser Gln Ser Leu Thr Ser Val Asp Leu Leu Asp Ile Asn Val 
            100                 105                 110         


Val Cys Trp Glu Glu Lys Gly Trp Arg Arg Val Lys Thr Cys Asp Phe 
        115                 120                 125             


His Pro Phe Asp Asn Leu Arg Leu Val Ala Pro His Ser Leu Gln Val 
    130                 135                 140                 


Leu His Ile Asp Thr Gln Arg Cys Asn Ile Ser Trp Lys Val Ser Gln 
145                 150                 155                 160 


Val Ser His Tyr Ile Glu Pro Tyr Leu Glu Phe Glu Ala Arg Arg Arg 
                165                 170                 175     


Leu Leu Gly His Ser Trp Glu Asp Ala Ser Val Leu Ser Leu Lys Gln 
            180                 185                 190         


Arg Gln Gln Trp Leu Phe Leu Glu Met Leu Ile Pro Ser Thr Ser Tyr 
        195                 200                 205             


Glu Val Gln Val Arg Val Lys Ala Gln Arg Asn Asn Thr Gly Thr Trp 
    210                 215                 220                 


Ser Pro Trp Ser Gln Pro Leu Thr Phe Arg Thr Arg Pro Ala Asp Pro 
225                 230                 235                 240 


Met Lys Glu Gly Ala Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  281
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine IL-2R-beta-Fc(hole) fusion protein

<400>  281
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt ccccctcctg       60

ctgctctggt tcccaggtgc caggtgtgca gtgaaaaact gttcccatct tgaatgcttc      120

tacaactcaa gagccaatgt ctcttgcatg tggagccatg aagaggctct gaatgtcaca      180

acctgccacg tccatgccaa gtcgaacctg cgacactgga acaaaacctg tgagctaact      240

cttgtgaggc aggcatcctg ggcctgcaac ctgatcctcg ggtcgttccc agagtcccag      300

tcactgacct ccgtggacct ccttgacata aatgtggtgt gctgggaaga gaagggttgg      360

cgtagggtaa agacctgcga cttccatccc tttgacaacc ttcgcctggt ggcccctcat      420

tccctccaag ttctgcacat tgatacccag agatgtaaca taagctggaa ggtctcccag      480

gtctctcact acattgaacc atacttggaa tttgaggccc gtagacgtct tctgggccac      540

agctgggagg atgcatccgt attaagcctc aagcagagac agcagtggct cttcttggag      600

atgctgatcc ctagtacctc atatgaggtc caggtgaggg tcaaagctca acgaaacaat      660

accgggacct ggagtccctg gagccagccc ctgacctttc ggacaaggcc agcagatccc      720

atgaaggagg gagctcagga caaaactcac acatgcccac cgtgcccagc acctgaactc      780

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      960

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1020

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtgcaccct gcccccatcc     1140

cgggatgagc tgaccaagaa ccaggtcagc ctctcgtgcg cagtcaaagg cttctatccc     1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1260

cctcccgtgc tggactccga cggctccttc ttcctcgtga gcaagctcac cgtggacaag     1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1380

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        1422


<210>  282
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine IL-2R-gamma-Fc(knob) fusion protein

<400>  282

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Leu Leu Leu Leu Trp Phe Pro Gly Ala Arg Cys Trp Ser Ser 
            20                  25                  30          


Lys Val Leu Met Ser Ser Ala Asn Glu Asp Ile Lys Ala Asp Leu Ile 
        35                  40                  45              


Leu Thr Ser Thr Ala Pro Glu His Leu Ser Ala Pro Thr Leu Pro Leu 
    50                  55                  60                  


Pro Glu Val Gln Cys Phe Val Phe Asn Ile Glu Tyr Met Asn Cys Thr 
65                  70                  75                  80  


Trp Asn Ser Ser Ser Glu Pro Gln Ala Thr Asn Leu Thr Leu His Tyr 
                85                  90                  95      


Arg Tyr Lys Val Ser Asp Asn Asn Thr Phe Gln Glu Cys Ser His Tyr 
            100                 105                 110         


Leu Phe Ser Lys Glu Ile Thr Ser Gly Cys Gln Ile Gln Lys Glu Asp 
        115                 120                 125             


Ile Gln Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp Pro Gln Lys 
    130                 135                 140                 


Pro Gln Arg Arg Ala Val Gln Lys Leu Asn Leu Gln Asn Leu Val Ile 
145                 150                 155                 160 


Pro Arg Ala Pro Glu Asn Leu Thr Leu Ser Asn Leu Ser Glu Ser Gln 
                165                 170                 175     


Leu Glu Leu Arg Trp Lys Ser Arg His Ile Lys Glu Arg Cys Leu Gln 
            180                 185                 190         


Tyr Leu Val Gln Tyr Arg Ser Asn Arg Asp Arg Ser Trp Thr Glu Leu 
        195                 200                 205             


Ile Val Asn His Glu Pro Arg Phe Ser Leu Pro Ser Val Asp Glu Leu 
    210                 215                 220                 


Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Tyr Asn Pro Ile Cys Gly 
225                 230                 235                 240 


Ser Ser Gln Gln Trp Ser Lys Trp Ser Gln Pro Val His Trp Gly Ser 
                245                 250                 255     


His Thr Val Glu Glu Asn Pro Ser Leu Phe Ala Leu Glu Ala Gly Ala 
            260                 265                 270         


Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys 
            500 


<210>  283
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine IL-2R-gamma-Fc(knob) fusion protein

<400>  283
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt ccccctcctg       60

ctgctctggt tcccaggtgc caggtgttgg agttccaagg tcctcatgtc cagtgcgaat      120

gaagacatca aagctgattt gatcctgact tctacagccc ctgaacacct cagtgctcct      180

actctgcccc ttccagaggt tcagtgcttt gtgttcaaca tagagtacat gaattgcact      240

tggaatagca gttctgagcc tcaggcaacc aacctcacgc tgcactatag gtacaaggta      300

tctgataata atacattcca ggagtgcagt cactatttgt tctccaaaga gattacttct      360

ggctgtcaga tacaaaaaga agatatccag ctctaccaga catttgttgt ccagctccag      420

gacccccaga aaccccagag gcgagctgta cagaagctaa acctacagaa tcttgtgatc      480

ccacgggctc cagaaaatct aacactcagc aatctgagtg aatcccagct agagctgaga      540

tggaaaagca gacatattaa agaacgctgt ttacaatact tggtgcagta ccggagcaac      600

agagatcgaa gctggacgga actaatagtg aatcatgaac ctagattctc cctgcctagt      660

gtggatgagc tgaaacggta cacatttcgg gttcggagcc gctataaccc aatctgtgga      720

agttctcaac agtggagtaa atggagccag cctgtccact gggggagtca tactgtagag      780

gagaatcctt ccttgtttgc actggaagct ggagctcagg acaaaactca cacatgccca      840

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatg ccgggatgag ctgaccaaga accaggtcag cctgtggtgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1500

tga                                                                   1503


<210>  284
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine IL-2R alpha subunit + Avi-tag + His-tag

<400>  284

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala 
            20                  25                  30          


Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu 
        35                  40                  45              


Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys 
    50                  55                  60                  


Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His 
65                  70                  75                  80  


Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu 
                85                  90                  95      


Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln 
            100                 105                 110         


Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu 
        115                 120                 125             


Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr 
    130                 135                 140                 


Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser 
145                 150                 155                 160 


Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu 
                165                 170                 175     


Thr Cys Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Gly Leu Asn 
            180                 185                 190         


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Ala Arg Ala His 
        195                 200                 205             


His His His His His 
    210             


<210>  285
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine IL-2R alpha subunit + Avi-tag + His-tag

<400>  285
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgaa       60

ctgtgtctgt atgacccacc cgaggtcccc aatgccacat tcaaagccct ctcctacaag      120

aacggcacca tcctaaactg tgaatgcaag agaggtttcc gaagactaaa ggaattggtc      180

tatatgcgtt gcttaggaaa ctcctggagc agcaactgcc agtgcaccag caactcccat      240

gacaaatcga gaaagcaagt tacagctcaa cttgaacacc agaaagagca acaaaccaca      300

acagacatgc agaagccaac acagtctatg caccaagaga accttacagg tcactgcagg      360

gagccacctc cttggaaaca tgaagattcc aagagaatct atcatttcgt ggaaggacag      420

agtgttcact acgagtgtat tccgggatac aaggctctac agagaggtcc tgctattagc      480

atctgcaaga tgaagtgtgg gaaaacgggg tggactcagc cccagctcac atgtgtcgac      540

gaacagttat attttcaggg cggctcaggc ctgaacgaca tcttcgaggc ccagaagatc      600

gagtggcacg aggctcgagc tcaccaccat caccatcact ga                         642


<210>  286
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgous IL-2R-beta-Fc(knob) fusion protein + Avi-tag

<400>  286

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ala Val Asn Gly Thr Ser Arg Phe Thr Cys Phe Tyr Asn 
            20                  25                  30          


Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln 
        35                  40                  45              


Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn 
    50                  55                  60                  


Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn 
65                  70                  75                  80  


Leu Ile Leu Gly Thr Pro Asp Ser Gln Lys Leu Thr Ala Val Asp Ile 
                85                  90                  95      


Val Thr Leu Arg Val Met Cys Arg Glu Gly Val Arg Trp Arg Met Met 
            100                 105                 110         


Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro 
        115                 120                 125             


Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser 
    130                 135                 140                 


Trp Lys Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe 
145                 150                 155                 160 


Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu 
                165                 170                 175     


Met Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr 
            180                 185                 190         


Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly 
        195                 200                 205             


Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr 
    210                 215                 220                 


Lys Pro Ala Ala Leu Gly Lys Asp Thr Gly Ala Gln Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
    450                 455                 460                 


Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
465                 470                 475                 480 


<210>  287
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cynomolgous IL-2R-beta-Fc(knob) fusion protein + Avi-tag

<400>  287
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgcg       60

gtcaacggca cttcccggtt cacatgcttc tacaactcga gagccaacat ctcctgtgtc      120

tggagccaag atggggctct gcaggacact tcctgccaag tccacgcctg gccggacaga      180

cggcggtgga accaaacctg tgagctgctc cctgtgagtc aagcatcctg ggcctgcaac      240

ctgatcctcg gaaccccaga ttctcagaaa ctgaccgcag tggatatcgt caccctgagg      300

gtgatgtgcc gtgaaggggt gcgatggagg atgatggcca tccaggactt caaacccttt      360

gagaaccttc gcctgatggc ccccatctcc ctccaagtcg tccacgtgga gacccacaga      420

tgcaacataa gctggaaaat ctcccaagcc tcccactact ttgaaagaca cctggagttt      480

gaggcccgga cgctgtcccc aggccacacc tgggaggagg cccccctgat gaccctcaag      540

cagaagcagg aatggatctg cctggagacg ctcaccccag acacccagta tgagtttcag      600

gtgcgggtca agcctctgca aggcgagttc acgacctgga gcccctggag ccagcccctg      660

gccttcagga caaagcctgc agcccttggg aaggacaccg gagctcagga caaaactcac      720

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      840

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      900

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      960

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1020

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1080

gaaccacagg tgtacaccct gcccccatgc cgggatgagc tgaccaagaa ccaggtcagc     1140

ctgtggtgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1200

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1380

ccgggtaaat ccggaggcct gaacgacatc ttcgaggccc agaagattga atggcacgag     1440

tga                                                                   1443


<210>  288
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgous IL-2R-gamma-Fc(hole) fusion protein

<400>  288

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp 
            20                  25                  30          


Ala Thr Thr Asp Phe Phe Leu Thr Ser Met Pro Thr Asp Ser Leu Ser 
        35                  40                  45              


Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val 
    50                  55                  60                  


Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr 
65                  70                  75                  80  


Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val 
                85                  90                  95      


Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys 
            100                 105                 110         


Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln 
        115                 120                 125             


Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys 
    130                 135                 140                 


Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu Arg 
145                 150                 155                 160 


Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu 
                165                 170                 175     


Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His 
            180                 185                 190         


Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro 
        195                 200                 205             


Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe 
    210                 215                 220                 


Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro 
225                 230                 235                 240 


Ile His Trp Gly Ser Asn Ser Ser Lys Glu Asn Pro Phe Leu Phe Ala 
                245                 250                 255     


Leu Glu Ala Gly Ala Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 


<210>  289
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cynomolgous IL-2R-gamma-Fc(hole) fusion protein

<400>  289
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccctg       60

aacacgacaa ttctgacgcc caatgggaat gaagacgcca caactgattt cttcctgacc      120

tctatgccca ctgactccct cagtgtttcc actctgcccc tcccagaggt tcagtgtttt      180

gtgttcaatg tcgagtacat gaattgcact tggaacagca gctctgagcc ccagcctacc      240

aacctcactc tgcattattg gtacaagaat tcggataatg ataaagtcca gaagtgcagc      300

cactatctat tctctgaaga aatcacttct ggctgtcagt tgcaaaaaaa ggagatccac      360

ctctaccaaa cgtttgttgt tcagctccag gacccacggg aacccaggag acaggccaca      420

cagatgctaa aactgcagaa tctggtgatc ccctgggctc cggagaacct aacacttcgc      480

aaactgagtg aatcccagct agaactgaac tggaacaaca gattcttgaa ccactgtttg      540

gagcacttgg tgcagtaccg gactgactgg gaccacagct ggactgaaca atcagtggat      600

tatagacata agttctcctt gcctagtgtg gatgggcaga aacgctacac gtttcgtgtc      660

cggagccgct ttaacccact ctgtggaagt gctcagcatt ggagtgaatg gagccaccca      720

atccactggg ggagcaatag ttcaaaagag aatcctttcc tgtttgcatt ggaagccgga      780

gctcaggaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      840

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      900

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      960

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     1020

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1080

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1140

gccaaagggc agccccgaga accacaggtg tgcaccctgc ccccatcccg ggatgagctg     1200

accaagaacc aggtcagcct ctcgtgcgca gtcaaaggct tctatcccag cgacatcgcc     1260

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1320

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag     1380

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1440

aagagcctct ccctgtctcc gggtaaatga                                      1470


<210>  290
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgous IL-2R alpha subunit + Avi-tag + His-tag

<400>  290

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Leu Cys Asp Asp Asp Pro Pro Lys Ile Thr His Ala Thr Phe Lys 
            20                  25                  30          


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
        35                  40                  45              


Gly Phe Arg Arg Ile Lys Ser Gly Ser Pro Tyr Met Leu Cys Thr Gly 
    50                  55                  60                  


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
65                  70                  75                  80  


Ala Ala Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
                85                  90                  95      


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Gln Met Gln Leu Ala Asp 
            100                 105                 110         


Gln Val Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
        115                 120                 125             


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Thr Val Tyr 
    130                 135                 140                 


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
145                 150                 155                 160 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
                165                 170                 175     


Leu Ile Cys Thr Gly Glu Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly 
            180                 185                 190         


Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        195                 200                 205             


Ala Arg Ala His His His His His His 
    210                 215         


<210>  291
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cynomolgous IL-2R alpha subunit + Avi-tag + His-tag

<400>  291
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtga gctctgtgac       60

gatgacccgc caaaaatcac acatgccaca ttcaaagcca tggcctacaa ggaaggaacc      120

atgttgaact gtgaatgcaa gagaggtttc cgcagaataa aaagcgggtc accctatatg      180

ctctgtacag gaaactctag ccactcgtcc tgggacaacc aatgtcaatg cacaagctct      240

gctgctcgga acacaacaaa acaagtgaca cctcaacctg aagaacagaa agaaagaaaa      300

accacagaaa tgcaaagtca aatgcagctg gcggaccaag tgagccttcc aggtcactgc      360

agggaacctc caccgtggga aaatgaagcc acagaaagaa tttatcattt cgtggtgggg      420

cagacggttt actaccagtg cgtccaggga tacagggctc tacacagagg tcctgctgag      480

agcgtctgca aaatgaccca cgggaagaca agatggaccc agccccagct catatgcaca      540

ggtgaagtcg acgaacagtt atattttcag ggcggctcag gcctgaacga catcttcgag      600

gcccagaaga tcgagtggca cgaggctcga gctcaccacc atcaccatca ctga            654


<210>  292
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type IL-2 (C125A) (4)

<400>  292
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  293
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant L72G (C125A) (4)

<400>  293
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  294
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 mutant L72G / F42A (C125A) (4)

<400>  294
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acagccaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  295
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 triple mutant F42A / Y45A / L72G (C125A) (4)

<400>  295
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  296
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 quadruple mutant T3A / F42A /Y45A /L72G (C125A) (4)

<400>  296
gcacctgcct caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct ttgcccaaag catcatctca acactgact                             399


<210>  297
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 Fab heavy chain-Fc (knob)-IL-2 qm

<400>  297

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Ser 
    450                 455                 460                 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
465                 470                 475                 480 


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
                485                 490                 495     


Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu 
            500                 505                 510         


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
        515                 520                 525             


Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
    530                 535                 540                 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
545                 550                 555                 560 


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
                565                 570                 575     


Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu 
            580                 585                 590         


Thr 
    


<210>  298
<211>  1779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28H1 Fab heavy chain-Fc (knob)-IL-2 qm

<400>  298
gaagtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc tcccacgcca tgtcctgggt ccgacaggct      120

cctggcaaag gcctggaatg ggtgtccgcc atctgggcct ccggcgagca gtactacgcc      180

gactctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgtgccaa gggctggctg      300

ggcaacttcg actactgggg acagggcacc ctggtcaccg tgtccagcgc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac     1080

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtggcgg cggaggctcc ggaggcggag gttctggcgg aggtggctcc     1380

gcacctgcct caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat     1440

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc     1500

acagccaagt ttgccatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa     1560

gaagaactca aacctctgga ggaagtgcta aatggcgctc aaagcaaaaa ctttcactta     1620

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa     1680

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga     1740

tggattacct ttgcccaaag catcatctca acactgact                            1779


<210>  299
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 Fab heavy chain-Fc (hole)

<400>  299

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  300
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28H1 Fab heavy chain-Fc (hole)

<400>  300
gaagtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc tcccacgcca tgtcctgggt ccgacaggct      120

cctggcaaag gcctggaatg ggtgtccgcc atctgggcct ccggcgagca gtactacgcc      180

gactctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgtgccaa gggctggctg      300

ggcaacttcg actactgggg acagggcacc ctggtcaccg tgtccagcgc tagcaccaag      360

ggcccctccg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgct      420

ctgggctgcc tggtcaagga ctacttcccc gagcccgtga ccgtgtcctg gaacagcgga      480

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agagttctgg cctgtatagc      540

ctgagcagcg tggtcaccgt gccttctagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgcgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtgcaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tctcgtgcgc agtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  301
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B9 Fab heavy chain-Fc (knob)-IL-2 qm

<400>  301

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala 
    450                 455                 460                 


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
465                 470                 475                 480 


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
                485                 490                 495     


Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr 
            500                 505                 510         


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
        515                 520                 525             


Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
    530                 535                 540                 


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
545                 550                 555                 560 


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
                565                 570                 575     


Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr 
            580                 585                 590         


Leu Thr 
        


<210>  302
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B9 Fab heavy chain-Fc (knob)-IL-2 qm

<400>  302
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcatcggct ctggcgccag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gccgggatga gctgaccaag     1080

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtgg cggcggaggc tccggaggcg gaggttctgg cggaggtggc     1380

tccgcacctg cctcaagttc tacaaagaaa acacagctac aactggagca tttactgctg     1440

gatttacaga tgattttgaa tggaattaat aattacaaga atcccaaact caccaggatg     1500

ctcacagcca agtttgccat gcccaagaag gccacagaac tgaaacatct tcagtgtcta     1560

gaagaagaac tcaaacctct ggaggaagtg ctaaatggcg ctcaaagcaa aaactttcac     1620

ttaagaccca gggacttaat cagcaatatc aacgtaatag ttctggaact aaagggatct     1680

gaaacaacat tcatgtgtga atatgctgat gagacagcaa ccattgtaga atttctgaac     1740

agatggatta cctttgccca aagcatcatc tcaacactga ct                        1782


<210>  303
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B9 Fab heavy chain-Fc (hole)

<400>  303

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  304
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B9 Fab heavy chain-Fc (hole)

<400>  304
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcatcggct ctggcgccag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggcccct ccgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcacagcc      420

gctctgggct gcctggtcaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc      480

ggagccctga cctccggcgt gcacaccttc cccgccgtgc tgcagagttc tggcctgtat      540

agcctgagca gcgtggtcac cgtgccttct agcagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgc      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  305
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DP47GS Fab heavy chain-Fc (knob)-IL-2 qm

<400>  305

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Ser Ser 
    450                 455                 460                 


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
465                 470                 475                 480 


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
                485                 490                 495     


Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr Glu Leu 
            500                 505                 510         


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
        515                 520                 525             


Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
    530                 535                 540                 


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
545                 550                 555                 560 


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
                565                 570                 575     


Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr Leu Thr 
            580                 585                 590         


<210>  306
<211>  1776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47GS Fab heavy chain-Fc (knob)-IL-2 qm

<400>  306
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag     1080

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtggcggcgg aggctccgga ggcggaggtt ctggcggagg tggctccgca     1380

cctgcctcaa gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta     1440

cagatgattt tgaatggaat taataattac aagaatccca aactcaccag gatgctcaca     1500

gccaagtttg ccatgcccaa gaaggccaca gaactgaaac atcttcagtg tctagaagaa     1560

gaactcaaac ctctggagga agtgctaaat ggcgctcaaa gcaaaaactt tcacttaaga     1620

cccagggact taatcagcaa tatcaacgta atagttctgg aactaaaggg atctgaaaca     1680

acattcatgt gtgaatatgc tgatgagaca gcaaccattg tagaatttct gaacagatgg     1740

attacctttg cccaaagcat catctcaaca ctgact                               1776


<210>  307
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DP47GS Fab heavy chain-Fc (hole)

<400>  307

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  308
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47GS Fab heavy chain-Fc (hole)

<400>  308
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccctccgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgctctg      420

ggctgcctgg tcaaggacta cttccccgag cccgtgaccg tgtcctggaa cagcggagcc      480

ctgacctccg gcgtgcacac cttccccgcc gtgctgcaga gttctggcct gtatagcctg      540

agcagcgtgg tcaccgtgcc ttctagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgcgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgtg caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctct cgtgcgcagt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tcgtgagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  309
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DP47GS light chain

<400>  309

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  310
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47GS light chain

<400>  310
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct gacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  311
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A; VL

<400>  311

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  312
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A; VL

<400>  312
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caag                                             324


<210>  313
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A; VH

<400>  313

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  314
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A; VH

<400>  314
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  315
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8 Fab heavy chain-Fc (knob)-IL-2 qm

<400>  315

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala 
    450                 455                 460                 


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
465                 470                 475                 480 


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
                485                 490                 495     


Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys Lys Ala Thr 
            500                 505                 510         


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
        515                 520                 525             


Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
    530                 535                 540                 


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
545                 550                 555                 560 


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
                565                 570                 575     


Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser Ile Ile Ser Thr 
            580                 585                 590         


Leu Thr 
        


<210>  316
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8 Fab heavy chain-Fc (knob)-IL-2 qm

<400>  316
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gccgggatga gctgaccaag     1080

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtgg cggcggaggc tccggaggcg gaggttctgg cggaggtggc     1380

tccgcacctg cctcaagttc tacaaagaaa acacagctac aactggagca tttactgctg     1440

gatttacaga tgattttgaa tggaattaat aattacaaga atcccaaact caccaggatg     1500

ctcacagcca agtttgccat gcccaagaag gccacagaac tgaaacatct tcagtgtcta     1560

gaagaagaac tcaaacctct ggaggaagtg ctaaatggcg ctcaaagcaa aaactttcac     1620

ttaagaccca gggacttaat cagcaatatc aacgtaatag ttctggaact aaagggatct     1680

gaaacaacat tcatgtgtga atatgctgat gagacagcaa ccattgtaga atttctgaac     1740

agatggatta cctttgccca aagcatcatc tcaacactga ct                        1782


<210>  317
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8 Fab heavy chain-Fc (hole)

<400>  317

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  318
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8 Fab heavy chain-Fc (hole)

<400>  318
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcacc      360

aagggcccct ccgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcacagcc      420

gctctgggct gcctggtcaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc      480

ggagccctga cctccggcgt gcacaccttc cccgccgtgc tgcagagttc tggcctgtat      540

agcctgagca gcgtggtcac cgtgccttct agcagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgc      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  319
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A Fab heavy chain-Fc (knob)-IL-2 qm

<400>  319

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
465                 470                 475                 480 


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
                485                 490                 495     


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala 
            500                 505                 510         


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
        515                 520                 525             


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn 
    530                 535                 540                 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
545                 550                 555                 560 


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
                565                 570                 575     


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala 
            580                 585                 590         


Gln Ser Ile Ile Ser Thr Leu Thr 
        595                 600 


<210>  320
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A Fab heavy chain-Fc (knob)-IL-2 qm

<400>  320
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agcgctagca ccaagggccc aagcgtgttc cctctggccc ccagcagcaa gagcacaagc      420

ggcggaacag ccgccctggg ctgcctggtc aaggactact tccccgagcc cgtgacagtg      480

tcctggaaca gcggagccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtc acagtgccta gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      660

cccaagagct gcgacaagac ccacacctgt cccccttgtc ctgcccctga gctgctgggc      720

ggacccagcg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc      780

cccgaagtga cctgcgtggt ggtggacgtg tcccacgagg accctgaagt gaagttcaat      840

tggtacgtgg acggcgtgga ggtgcacaat gccaagacca agccccggga ggaacagtac      900

aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagagtaca agtgcaaggt ctccaacaag gccctgcctg cccccatcga gaaaaccatc     1020

agcaaggcca agggccagcc cagagaaccc caggtgtaca ccctgccccc ctgcagagat     1080

gagctgacca agaaccaggt gtccctgtgg tgtctggtca agggcttcta ccccagcgat     1140

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac caccccccct     1200

gtgctggaca gcgacggcag cttcttcctg tactccaaac tgaccgtgga caagagccgg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gagccccggc aagtccggag gcggaggctc cggcggcgga     1380

ggttctggcg gaggtggctc cgcacctgcc tcaagttcta caaagaaaac acagctacaa     1440

ctggagcatt tactgctgga tttacagatg attttgaatg gaattaataa ttacaagaat     1500

cccaaactca ccaggatgct cacagccaag tttgccatgc ccaagaaggc cacagaactg     1560

aaacatcttc agtgtctaga agaagaactc aaacctctgg aggaagtgct aaatggcgct     1620

caaagcaaaa actttcactt aagacccagg gacttaatca gcaatatcaa cgtaatagtt     1680

ctggaactaa agggatctga aacaacattc atgtgtgaat atgctgatga gacagcaacc     1740

attgtagaat ttctgaacag atggattacc tttgcccaaa gcatcatctc aacactgact     1800


<210>  321
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A Fab heavy chain-Fc (hole)

<400>  321

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  322
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A Fab heavy chain-Fc (hole)

<400>  322
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agcgctagca ccaagggccc aagcgtgttc cctctggccc ccagcagcaa gagcacaagc      420

ggcggaacag ccgccctggg ctgcctggtc aaggactact tccccgagcc cgtgacagtg      480

tcctggaaca gcggagccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtc acagtgccta gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      660

cccaagagct gcgacaagac ccacacctgt cccccttgtc ctgcccctga gctgctgggc      720

ggacccagcg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc      780

cccgaagtga cctgcgtggt ggtggacgtg tcccacgagg accctgaagt gaagttcaat      840

tggtacgtgg acggcgtgga ggtgcacaat gccaagacca agccccggga ggaacagtac      900

aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagagtaca agtgcaaggt ctccaacaag gccctgcctg cccccatcga gaaaaccatc     1020

agcaaggcca agggccagcc cagagaaccc caggtgtgca ccctgccccc cagcagagat     1080

gagctgacca agaaccaggt gtccctgagc tgtgccgtca agggcttcta ccccagcgat     1140

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac caccccccct     1200

gtgctggaca gcgacggcag cttcttcctg gtgtccaaac tgaccgtgga caagagccgg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gagccccggc aag                                  1353


<210>  323
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A light chain

<400>  323

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  324
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A light chain

<400>  324
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


