
                                SEQUENCE LISTING

<110> SARWAL, MINNIE M.
      Li, Li
      STROBER, SAMUEL

<120> Biomarkers for Determining an Allograft
  Tolerant Phenotype

<130> STAN-708WO2

<150> 61/439,288          
<151> 2011-02-03  

<160> 14

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 8380
<212> DNA
<213> homo sapiens

<400> 1
acaccacttg tgtctgagtt cacgcagcat gttcctctgt cagggattcc gcaaatatct 60
ccctgaggta aaaaaggaaa gtgtgctgcg ctccagcacc cagagcagtg agcccagtcc 120
cgagtcccgg agagagctcc agcaataggg gccatgtcgc cgtagcccca gcctctcggt 180
ccgcagcctc agcagcgtcc cagccggctg gcttcatgct gcggtgcagc tgcaccatgt 240
tcctgggttg agggggcaat cgggcacgct cctccccatg ggttgcccat catgtctaat 300
ggatatcgca ctctgtccca gcacctcaat gacctgaaga aggagaactt cagcctcaag 360
ctgcgcatct acttcctgga ggagcgcatg caacagaagt atgaggccag ccgggaggac 420
atctacaagc ggaacattga gctgaaggtt gaagtggaga gcttgaaacg agaactccag 480
gacaagaaac agcatctgga taaaacatgg gctgatgtgg agaatctcaa cagtcagaat 540
gaagctgagc tccgacgcca gtttgaggag cgacagcagg agacggagca tgtttatgag 600
ctcttggaga ataagatcca gcttctgcag gaggaatcca ggctagcaaa gaatgaagct 660
gcgcggatgg cagctctggt ggaagcagag aaggagtgta acctggagct ctcagagaaa 720
ctgaagggag tcaccaaaaa ctgggaagat gtaccaggag accaggtcaa gcccgaccaa 780
tacactgagg ccctggccca gagggacaag agaattgaag aactgaatca gagcctggct 840
gcccaggaga ggcttgtaga acagctatct cgggagaaac aacaactgct acatctgttg 900
gaggagccaa ctagcatgga agtgcagccc atgactgaag agttgctgaa acaacaaaag 960
ctgaattcac atgagaccac tataactcag cagtctgtat ctgattccca cttggcagaa 1020
ctccaggaaa aaatccagca aacagaggcc accaacaaga ttcttcaaga gaaacttaat 1080
gaaatgagct atgaactaaa gtgtgctcag gagtcgtctc aaaagcaaga tggtacaatt 1140
cagaacctca aggaaactct gaaaagcagg gaacgtgaga ctgaggagtt gtaccaggta 1200
attgaaggtc aaaatgacac aatggcaaag cttcgagaaa tgctgcacca aagccagctt 1260
ggacaacttc acagctcaga gggtacttct ccagctcagc aacaggtagc tctgcttgat 1320
cttcagagtg ctttattctg cagccaactt gaaatacaga agctccagag ggtggtacga 1380
cagaaagagc gccaactggc tgatgccaaa caatgtgtgc aatttgtaga ggctgcagca 1440
cacgagagtg aacagcagaa agaggcttct tggaaacata accaggaatt gcgaaaagcc 1500
ttgcagcagc tacaagaaga attgcagaat aagagccaac agcttcgtgc ctgggaggct 1560
gaaaaataca atgagattcg aacccaggaa caaaacatcc agcacctaaa ccatagtctg 1620
agtcacaagg agcagttgct tcaggaattt cgggagctcc tacagtatcg agataactca 1680
gacaaaaccc ttgaagcaaa tgaaatgttg cttgagaaac ttcgccagcg aatacatgat 1740
aaagctgttg ctctggagcg ggctatagat gaaaaattct ctgctctaga agagaaagaa 1800
aaagaactgc gccagcttcg tcttgctgtg agagagcgag atcatgactt agagagactg 1860
cgcgatgtcc tctcctccaa tgaagctact atgcaaagta tggagagtct cctgagggcc 1920
aaaggcctgg aagtggaaca gttatctact acctgtcaaa acctccagtg gctgaaagaa 1980
gaaatggaaa ccaaatttag ccgttggcag aaggaacaag agagtatcat tcagcagtta 2040
cagacgtctc ttcatgatag gaacaaagaa gtggaggatc ttagtgcaac actgctctgc 2100
aaacttggac cagggcagag tgagatagca gaggagctgt gccagcgtct acagcgaaag 2160
gaaaggatgc tgcaggacct tctaagtgat cgaaataaac aagtgctgga acatgaaatg 2220
gagattcaag gcctgcttca gtctgtgagc accagggagc aggaaagcca agctgctgca 2280
gagaagttgg tgcaagcctt aatggaaaga aattcagaat tacaggccct gcgccaatat 2340
ttaggaggga gagactccct gatgtcccaa gcacccatct ctaaccaaca agctgaagtt 2400
acccccactg gctgtcttgg aaaacagact gatcaaggtt caatgcagat accttccaga 2460
gatgatagca cttcattgac tgccaaagag gatgtcagca tacccagatc cacattagga 2520
gacttggaca cagttgcagg gctggaaaaa gaactgagta atgccaaaga ggaacttgaa 2580
ctcatggcta aaaaagaaag agaaagtcag atggaacttt ctgctctaca gtccatgatg 2640
gctgtgcagg aagaagagct gcaggtgcag gctgctgata tggagtctct gaccaggaac 2700
atacagatta aagaagatct cataaaggac ctgcaaatgc aactggttga tcctgaagac 2760
ataccagcta tggaacgcct gacccaggaa gtcttacttc ttcgggaaaa agttgcttca 2820
gtagaatccc agggtcaaga aatttcagga aaccgaagac aacagttgct gctgatgcta 2880
gaaggactag tagatgaacg gagtcggctc aatgaggcct tacaagcaga gagacagctc 2940
tatagcagtc tggtgaagtt ccatgcccat ccagagagct ctgagagaga ccgaactctg 3000
caggtggaac tggaaggggc tcaggtgtta cgcagtcggc tagaagaagt tcttggaaga 3060
agcttggagc gcttaaacag gctggagacc ctggccgcca ttggaggtgc agctgcaggg 3120
gatgacaccg aagatacaag cactgagttc actgacagta ttgaggagga ggctgcacac 3180
catagtcacc agcaacttgt caaggtggct ttggagaaaa gtctggcaac tgtggagacc 3240
cagaacccat ctttttcccc tccttctccg atgggagggg acagtaacag gtgtcttcag 3300
gaagaaatgc tccacctgag ggctgagttc caccagcact tagaagagaa gaggaaagct 3360
gaggaggaac tgaaggagct aaaggctcaa attgaggaag caggattctc ctcagtgtcc 3420
cacatcagga acaccatgct gagcctttgc cttgagaatg cggagctgaa agagcagatg 3480
ggagaagcaa tgtctgatgg atgggagatc gaggaagaca aggagaaggg cgaggtgatg 3540
gttgagactg tggtaaccaa agagggtctg agtgagagta gccttcaggc tgagttcaga 3600
aagctccagg gaaaactgaa gaatgcccac aatatcatca acctcctcaa agaacaactt 3660
gtgctgagta gcaaggaagg gaatagtaaa cttactccag agctccttgt gcatctgacc 3720
agcaccattg aaagaataaa cacagaactg gttggttccc ctgggaagca ccaacaccaa 3780
gaggagggga atgtgactgt gaggcctttc cccagacccc agagccttga ccttggggct 3840
accttcacag tggatgccca ccaattggat aaccagtccc agcctcgtga ccctgggcct 3900
cagtcagcgt ttagcctacc agggtccacc cagcacctgc gctcccagct gtcacaatgc 3960
aaacaacgct atcaagatct ccaggagaag ctgctgctat cagaagccac tgtctttgct 4020
caggctaacg agctggagaa atacagagtt atgcttacag gtgaatcctt ggtgaagcag 4080
gacagcaagc agatccaggt ggacctccag gacctgggct atgagacttg tggccgaagc 4140
gagaatgagg ctgaacggga ggaaaccacc agtcctgagt gtgaggagca caacagcctc 4200
aaggaaatgg tcctgatgga ggggctgtgc tctgagcagg gacgccgggg ctcaacactg 4260
gctagttcct ctgagaggaa gcccttggag aaccagctag ggaagcagga agagttccgg 4320
gtatatggaa agtcagaaaa catcttggtc ctacgaaagg acatcaaaga tctgaaggcc 4380
cagctgcaga atgccaacaa ggtcattcaa aacctcaaga gccgggtccg gtccctctca 4440
gttacaagtg attattcgtc tagtctggaa agaccctgga agctgagagc tgttggcacc 4500
ttggaggggt cttcacctca tagtgtccct gatgaggatg aggggtggct gtctgatggc 4560
actggggctt tctactctcc agggcttcag gccaaaaagg acctggagag tctcatccag 4620
agagtatccc agctggaggc ccagctccca aaaaatggac tagaagagaa gctggctgag 4680
gagctgagat cagcctcgtg gcctgggaaa tatgattccc tgattcagga tcaggcccgg 4740
gaactgtctt acctacggca aaaaatacga gaagggagag gtatttgtta tcttatcacc 4800
cggcatgcaa aagatacagt aaaatctttt gaggatctcc taaggagcaa tgacattgac 4860
tactacctgg gacagagctt ccgggagcaa ctcgcccagg gaagccagct gacagagagg 4920
ctcaccagca aactcagcac caaggatcat aaaagtgaga aagatcaagc tggacttgag 4980
ccactggccc tcaggctcag cagggagctg caggagaagg agaaagtgat tgaagtcctg 5040
caggccaagc tggatgctcg gtccctcaca ccctccagca gccatgcctt gtctgactcc 5100
caccgctctc ccagcagcac ctctttcctg tctgatgaac tggaagcctg ctctgacatg 5160
gacatagtca gcgagtacac acactatgaa gagaagaaag cttctcccag tcactcagat 5220
tccatccatc attcgagtca ttctgctgtg ttgtcttcta aaccatcatc aaccagtgca 5280
tctcaggggg ctaaggccga atccaacagc aaccccatca gcttgccaac tccccagaat 5340
acccccaagg aggccaacca ggcccattca ggctttcatt ttcactccat acccaagctg 5400
gctagccttc ctcaggcacc attgccctca gctccatcca gcttcctgcc tttcagcccc 5460
actggccctc tcctccttgg ctgctgtgag acaccagtgg tctccttggc tgaggctcag 5520
caggagctac agatgctgca gaagcagttg ggagaaagtg ccagcactgt tcctcctgct 5580
tccacagcta cattgctgag caacgacttg gaagccgact cttcctacta cctcaactct 5640
gcccagcctc actctcctcc aaggggcacc atagaactgg gaagaatcct agagcctggg 5700
tacctgggca gcagtggcaa gtgggatgtg atgaggcctc agaaagggag tgtatctggg 5760
gacctatcct caggctcctc tgtgtaccag cttaactcca aacccacagg ggctgacctg 5820
ctggaagagc atcttggtga aatccggaac ctgcgccagc gcctggagga atccatctgc 5880
atcaatgacc gcctacggga gcaactggaa caccggctga cctctactgc tcgtggaagg 5940
ggatccactt ctaacttcta cagtcagggc ctggagtcca tacctcagct ctgcaatgag 6000
aacagagtcc tcagggaaga caatcgaaga cttcaggctc aactgagtca tgtttccaga 6060
gagcactccc aggaaacaga aagcctgagg gaggctctgc tgtcctctcg atcccacctt 6120
caagagctgg aaaaggagct ggagcaccag aaggtggaaa ggcagcagct tttggaagac 6180
ttgagggaga agcagcaaga ggtcttgcat ttcagggagg aacgtctttc cctccaggaa 6240
aacgactcca gactgcagca caagctggtt ctcctgcagc aacagtgtga agagaaacag 6300
cagctctttg agtccctcca gtcagagcta caaatctacg aggcacttta tggcaattcc 6360
aagaaggggc tgaaagctta cagcctggat gcctgtcacc aaatcccttt gagcagtgac 6420
ctgagccacc tggtggcaga ggtacgagct ctgagagggc agctggagca gagcattcag 6480
gggaacaatt gtctgcgact gcagctgcaa cagcagctgg agagcggtgc tggcaaagcc 6540
agcctcagcc cctcctccat taaccagaac ttcccagcca gcactgaccc tggaaacaag 6600
cagctgctcc tccaagattc agctgtgtcc cctccagtcc gggatgttgg tatgaattcc 6660
ccagctctgg tcttccccag ctctgcttcc tctactcctg gctcagaaac gcccataatc 6720
aacagagcaa atggcttggg tttggatact tctccagtaa tgaagacccc tcccaagcta 6780
gagggtgatg ctactgatgg ctcctttgcc aataagcatg gccgccatgt cattggccac 6840
attgatgact acagtgccct aagacagcag attgcggagg gcaagctgct ggtcaaaaag 6900
atagtgtctc ttgtgagatc agcgtgcagc ttccctggcc ttgaagccca aggcacagag 6960
gtgctaggca gcaaaggtat tcatgagctt cggagcagca ccagtgccct gcaccatgcc 7020
ctagaggagt cagcttccct cctcaccatg ttctggagag cggccctgcc aagcacccac 7080
atccctgtgc tgcctggcaa agtgggagaa tcaacagaaa gggaacttct ggaactgaga 7140
accaaagtat ccaaacagga gcgactcctt cagagcacaa ctgagcatct gaagaacgcc 7200
aaccagcaga aggagagcat ggaacagttc attgtcagcc agctaaccag aacacatgat 7260
gttttaaaga aggcaaggac taacttagag gtgaaatccc taagggctct gccatgtact 7320
ccagccttgt gacccttgcc ttccaggaac catgcaagaa gcgcagccac cagaagtcct 7380
taaaacagca ggaaaggtgg gcctgtcccc cttttgtgca gctacctatc tgctgaggag 7440
catctgggcc tcattcctcc aagtccacgg gagggtccag aagagggagt cagagatgta 7500
tcctggtgga gctgggagaa aggcagaaag cctttctgac ggctatggaa tacgattagc 7560
caaggtccac ttggcccagc actaagaaaa agatgcgtag tttgcacaga aggttttgtg 7620
atcctgcctc tcaacagccc cagcagcttg ggaactagca agagcacatt tcttgcctca 7680
tcagctgtcc tgagatggaa aactcagtga atataggacc ctgattccga tgaaaggggc 7740
acgtggtccc aatgctggag ctcctctggc aggttctaaa agcacactac tgagcagcgg 7800
tgccctgccg gacactgctg gcgggggctc agtgagcact actcacagat ccacacctga 7860
ccctgttggg tcgagtcagg ctgggccttg gtctgcactg tagcacctgt gttctttgag 7920
ttcacatcat gaatgtggtg acttcccaga taccatctca ggcttaacct agcacatcct 7980
atttcttttc ttctatgata tccaaattgg actgacctca cttcaaagtt gctgtcccat 8040
tttgtcaccc tatcttatct cggggaaatt gcagactgat ggccagacca actctgttga 8100
aattcttgca tagagcaaac ctgtgctcat ttttaagtgg catgggagag gccccaagcc 8160
tagtaaagcc tagtctgtgt cttcacagtg ctggtagaat gtgtttgtgt gtataaatat 8220
atgatataga tttatatatg ttgctaacgc catatattga aggccaacat aactggtgga 8280
cagggtgggt gacagaaaat gaaagtcttt ttggtgattg ttaaagcaag atgtgtataa 8340
agaaataaat agtttttctt tcaaaaaaaa aaaaaaaaaa                       8380



<210> 2
<211> 2346
<212> PRT
<213> homo sapiens

<400> 2
Met Ser Asn Gly Tyr Arg Thr Leu Ser Gln His Leu Asn Asp Leu Lys
 1               5                  10                  15      
Lys Glu Asn Phe Ser Leu Lys Leu Arg Ile Tyr Phe Leu Glu Glu Arg
            20                  25                  30          
Met Gln Gln Lys Tyr Glu Ala Ser Arg Glu Asp Ile Tyr Lys Arg Asn
        35                  40                  45              
Ile Glu Leu Lys Val Glu Val Glu Ser Leu Lys Arg Glu Leu Gln Asp
    50                  55                  60                  
Lys Lys Gln His Leu Asp Lys Thr Trp Ala Asp Val Glu Asn Leu Asn
65                  70                  75                  80  
Ser Gln Asn Glu Ala Glu Leu Arg Arg Gln Phe Glu Glu Arg Gln Gln
                85                  90                  95      
Glu Thr Glu His Val Tyr Glu Leu Leu Glu Asn Lys Ile Gln Leu Leu
            100                 105                 110         
Gln Glu Glu Ser Arg Leu Ala Lys Asn Glu Ala Ala Arg Met Ala Ala
        115                 120                 125             
Leu Val Glu Ala Glu Lys Glu Cys Asn Leu Glu Leu Ser Glu Lys Leu
    130                 135                 140                 
Lys Gly Val Thr Lys Asn Trp Glu Asp Val Pro Gly Asp Gln Val Lys
145                 150                 155                 160 
Pro Asp Gln Tyr Thr Glu Ala Leu Ala Gln Arg Asp Lys Arg Ile Glu
                165                 170                 175     
Glu Leu Asn Gln Ser Leu Ala Ala Gln Glu Arg Leu Val Glu Gln Leu
            180                 185                 190         
Ser Arg Glu Lys Gln Gln Leu Leu His Leu Leu Glu Glu Pro Thr Ser
        195                 200                 205             
Met Glu Val Gln Pro Met Thr Glu Glu Leu Leu Lys Gln Gln Lys Leu
    210                 215                 220                 
Asn Ser His Glu Thr Thr Ile Thr Gln Gln Ser Val Ser Asp Ser His
225                 230                 235                 240 
Leu Ala Glu Leu Gln Glu Lys Ile Gln Gln Thr Glu Ala Thr Asn Lys
                245                 250                 255     
Ile Leu Gln Glu Lys Leu Asn Glu Met Ser Tyr Glu Leu Lys Cys Ala
            260                 265                 270         
Gln Glu Ser Ser Gln Lys Gln Asp Gly Thr Ile Gln Asn Leu Lys Glu
        275                 280                 285             
Thr Leu Lys Ser Arg Glu Arg Glu Thr Glu Glu Leu Tyr Gln Val Ile
    290                 295                 300                 
Glu Gly Gln Asn Asp Thr Met Ala Lys Leu Arg Glu Met Leu His Gln
305                 310                 315                 320 
Ser Gln Leu Gly Gln Leu His Ser Ser Glu Gly Thr Ser Pro Ala Gln
                325                 330                 335     
Gln Gln Val Ala Leu Leu Asp Leu Gln Ser Ala Leu Phe Cys Ser Gln
            340                 345                 350         
Leu Glu Ile Gln Lys Leu Gln Arg Val Val Arg Gln Lys Glu Arg Gln
        355                 360                 365             
Leu Ala Asp Ala Lys Gln Cys Val Gln Phe Val Glu Ala Ala Ala His
    370                 375                 380                 
Glu Ser Glu Gln Gln Lys Glu Ala Ser Trp Lys His Asn Gln Glu Leu
385                 390                 395                 400 
Arg Lys Ala Leu Gln Gln Leu Gln Glu Glu Leu Gln Asn Lys Ser Gln
                405                 410                 415     
Gln Leu Arg Ala Trp Glu Ala Glu Lys Tyr Asn Glu Ile Arg Thr Gln
            420                 425                 430         
Glu Gln Asn Ile Gln His Leu Asn His Ser Leu Ser His Lys Glu Gln
        435                 440                 445             
Leu Leu Gln Glu Phe Arg Glu Leu Leu Gln Tyr Arg Asp Asn Ser Asp
    450                 455                 460                 
Lys Thr Leu Glu Ala Asn Glu Met Leu Leu Glu Lys Leu Arg Gln Arg
465                 470                 475                 480 
Ile His Asp Lys Ala Val Ala Leu Glu Arg Ala Ile Asp Glu Lys Phe
                485                 490                 495     
Ser Ala Leu Glu Glu Lys Glu Lys Glu Leu Arg Gln Leu Arg Leu Ala
            500                 505                 510         
Val Arg Glu Arg Asp His Asp Leu Glu Arg Leu Arg Asp Val Leu Ser
        515                 520                 525             
Ser Asn Glu Ala Thr Met Gln Ser Met Glu Ser Leu Leu Arg Ala Lys
    530                 535                 540                 
Gly Leu Glu Val Glu Gln Leu Ser Thr Thr Cys Gln Asn Leu Gln Trp
545                 550                 555                 560 
Leu Lys Glu Glu Met Glu Thr Lys Phe Ser Arg Trp Gln Lys Glu Gln
                565                 570                 575     
Glu Ser Ile Ile Gln Gln Leu Gln Thr Ser Leu His Asp Arg Asn Lys
            580                 585                 590         
Glu Val Glu Asp Leu Ser Ala Thr Leu Leu Cys Lys Leu Gly Pro Gly
        595                 600                 605             
Gln Ser Glu Ile Ala Glu Glu Leu Cys Gln Arg Leu Gln Arg Lys Glu
    610                 615                 620                 
Arg Met Leu Gln Asp Leu Leu Ser Asp Arg Asn Lys Gln Val Leu Glu
625                 630                 635                 640 
His Glu Met Glu Ile Gln Gly Leu Leu Gln Ser Val Ser Thr Arg Glu
                645                 650                 655     
Gln Glu Ser Gln Ala Ala Ala Glu Lys Leu Val Gln Ala Leu Met Glu
            660                 665                 670         
Arg Asn Ser Glu Leu Gln Ala Leu Arg Gln Tyr Leu Gly Gly Arg Asp
        675                 680                 685             
Ser Leu Met Ser Gln Ala Pro Ile Ser Asn Gln Gln Ala Glu Val Thr
    690                 695                 700                 
Pro Thr Gly Cys Leu Gly Lys Gln Thr Asp Gln Gly Ser Met Gln Ile
705                 710                 715                 720 
Pro Ser Arg Asp Asp Ser Thr Ser Leu Thr Ala Lys Glu Asp Val Ser
                725                 730                 735     
Ile Pro Arg Ser Thr Leu Gly Asp Leu Asp Thr Val Ala Gly Leu Glu
            740                 745                 750         
Lys Glu Leu Ser Asn Ala Lys Glu Glu Leu Glu Leu Met Ala Lys Lys
        755                 760                 765             
Glu Arg Glu Ser Gln Met Glu Leu Ser Ala Leu Gln Ser Met Met Ala
    770                 775                 780                 
Val Gln Glu Glu Glu Leu Gln Val Gln Ala Ala Asp Met Glu Ser Leu
785                 790                 795                 800 
Thr Arg Asn Ile Gln Ile Lys Glu Asp Leu Ile Lys Asp Leu Gln Met
                805                 810                 815     
Gln Leu Val Asp Pro Glu Asp Ile Pro Ala Met Glu Arg Leu Thr Gln
            820                 825                 830         
Glu Val Leu Leu Leu Arg Glu Lys Val Ala Ser Val Glu Ser Gln Gly
        835                 840                 845             
Gln Glu Ile Ser Gly Asn Arg Arg Gln Gln Leu Leu Leu Met Leu Glu
    850                 855                 860                 
Gly Leu Val Asp Glu Arg Ser Arg Leu Asn Glu Ala Leu Gln Ala Glu
865                 870                 875                 880 
Arg Gln Leu Tyr Ser Ser Leu Val Lys Phe His Ala His Pro Glu Ser
                885                 890                 895     
Ser Glu Arg Asp Arg Thr Leu Gln Val Glu Leu Glu Gly Ala Gln Val
            900                 905                 910         
Leu Arg Ser Arg Leu Glu Glu Val Leu Gly Arg Ser Leu Glu Arg Leu
        915                 920                 925             
Asn Arg Leu Glu Thr Leu Ala Ala Ile Gly Gly Ala Ala Ala Gly Asp
    930                 935                 940                 
Asp Thr Glu Asp Thr Ser Thr Glu Phe Thr Asp Ser Ile Glu Glu Glu
945                 950                 955                 960 
Ala Ala His His Ser His Gln Gln Leu Val Lys Val Ala Leu Glu Lys
                965                 970                 975     
Ser Leu Ala Thr Val Glu Thr Gln Asn Pro Ser Phe Ser Pro Pro Ser
            980                 985                 990         
Pro Met Gly Gly Asp Ser Asn Arg Cys Leu Gln Glu Glu Met Leu His
        995                 1000                1005            
Leu Arg Ala Glu Phe His Gln His Leu Glu Glu Lys Arg Lys Ala Glu
    1010                1015                1020                
Glu Glu Leu Lys Glu Leu Lys Ala Gln Ile Glu Glu Ala Gly Phe Ser
1025                1030                1035                1040
Ser Val Ser His Ile Arg Asn Thr Met Leu Ser Leu Cys Leu Glu Asn
                1045                1050                1055    
Ala Glu Leu Lys Glu Gln Met Gly Glu Ala Met Ser Asp Gly Trp Glu
            1060                1065                1070        
Ile Glu Glu Asp Lys Glu Lys Gly Glu Val Met Val Glu Thr Val Val
        1075                1080                1085            
Thr Lys Glu Gly Leu Ser Glu Ser Ser Leu Gln Ala Glu Phe Arg Lys
    1090                1095                1100                
Leu Gln Gly Lys Leu Lys Asn Ala His Asn Ile Ile Asn Leu Leu Lys
1105                1110                1115                1120
Glu Gln Leu Val Leu Ser Ser Lys Glu Gly Asn Ser Lys Leu Thr Pro
                1125                1130                1135    
Glu Leu Leu Val His Leu Thr Ser Thr Ile Glu Arg Ile Asn Thr Glu
            1140                1145                1150        
Leu Val Gly Ser Pro Gly Lys His Gln His Gln Glu Glu Gly Asn Val
        1155                1160                1165            
Thr Val Arg Pro Phe Pro Arg Pro Gln Ser Leu Asp Leu Gly Ala Thr
    1170                1175                1180                
Phe Thr Val Asp Ala His Gln Leu Asp Asn Gln Ser Gln Pro Arg Asp
1185                1190                1195                1200
Pro Gly Pro Gln Ser Ala Phe Ser Leu Pro Gly Ser Thr Gln His Leu
                1205                1210                1215    
Arg Ser Gln Leu Ser Gln Cys Lys Gln Arg Tyr Gln Asp Leu Gln Glu
            1220                1225                1230        
Lys Leu Leu Leu Ser Glu Ala Thr Val Phe Ala Gln Ala Asn Glu Leu
        1235                1240                1245            
Glu Lys Tyr Arg Val Met Leu Thr Gly Glu Ser Leu Val Lys Gln Asp
    1250                1255                1260                
Ser Lys Gln Ile Gln Val Asp Leu Gln Asp Leu Gly Tyr Glu Thr Cys
1265                1270                1275                1280
Gly Arg Ser Glu Asn Glu Ala Glu Arg Glu Glu Thr Thr Ser Pro Glu
                1285                1290                1295    
Cys Glu Glu His Asn Ser Leu Lys Glu Met Val Leu Met Glu Gly Leu
            1300                1305                1310        
Cys Ser Glu Gln Gly Arg Arg Gly Ser Thr Leu Ala Ser Ser Ser Glu
        1315                1320                1325            
Arg Lys Pro Leu Glu Asn Gln Leu Gly Lys Gln Glu Glu Phe Arg Val
    1330                1335                1340                
Tyr Gly Lys Ser Glu Asn Ile Leu Val Leu Arg Lys Asp Ile Lys Asp
1345                1350                1355                1360
Leu Lys Ala Gln Leu Gln Asn Ala Asn Lys Val Ile Gln Asn Leu Lys
                1365                1370                1375    
Ser Arg Val Arg Ser Leu Ser Val Thr Ser Asp Tyr Ser Ser Ser Leu
            1380                1385                1390        
Glu Arg Pro Trp Lys Leu Arg Ala Val Gly Thr Leu Glu Gly Ser Ser
        1395                1400                1405            
Pro His Ser Val Pro Asp Glu Asp Glu Gly Trp Leu Ser Asp Gly Thr
    1410                1415                1420                
Gly Ala Phe Tyr Ser Pro Gly Leu Gln Ala Lys Lys Asp Leu Glu Ser
1425                1430                1435                1440
Leu Ile Gln Arg Val Ser Gln Leu Glu Ala Gln Leu Pro Lys Asn Gly
                1445                1450                1455    
Leu Glu Glu Lys Leu Ala Glu Glu Leu Arg Ser Ala Ser Trp Pro Gly
            1460                1465                1470        
Lys Tyr Asp Ser Leu Ile Gln Asp Gln Ala Arg Glu Leu Ser Tyr Leu
        1475                1480                1485            
Arg Gln Lys Ile Arg Glu Gly Arg Gly Ile Cys Tyr Leu Ile Thr Arg
    1490                1495                1500                
His Ala Lys Asp Thr Val Lys Ser Phe Glu Asp Leu Leu Arg Ser Asn
1505                1510                1515                1520
Asp Ile Asp Tyr Tyr Leu Gly Gln Ser Phe Arg Glu Gln Leu Ala Gln
                1525                1530                1535    
Gly Ser Gln Leu Thr Glu Arg Leu Thr Ser Lys Leu Ser Thr Lys Asp
            1540                1545                1550        
His Lys Ser Glu Lys Asp Gln Ala Gly Leu Glu Pro Leu Ala Leu Arg
        1555                1560                1565            
Leu Ser Arg Glu Leu Gln Glu Lys Glu Lys Val Ile Glu Val Leu Gln
    1570                1575                1580                
Ala Lys Leu Asp Ala Arg Ser Leu Thr Pro Ser Ser Ser His Ala Leu
1585                1590                1595                1600
Ser Asp Ser His Arg Ser Pro Ser Ser Thr Ser Phe Leu Ser Asp Glu
                1605                1610                1615    
Leu Glu Ala Cys Ser Asp Met Asp Ile Val Ser Glu Tyr Thr His Tyr
            1620                1625                1630        
Glu Glu Lys Lys Ala Ser Pro Ser His Ser Asp Ser Ile His His Ser
        1635                1640                1645            
Ser His Ser Ala Val Leu Ser Ser Lys Pro Ser Ser Thr Ser Ala Ser
    1650                1655                1660                
Gln Gly Ala Lys Ala Glu Ser Asn Ser Asn Pro Ile Ser Leu Pro Thr
1665                1670                1675                1680
Pro Gln Asn Thr Pro Lys Glu Ala Asn Gln Ala His Ser Gly Phe His
                1685                1690                1695    
Phe His Ser Ile Pro Lys Leu Ala Ser Leu Pro Gln Ala Pro Leu Pro
            1700                1705                1710        
Ser Ala Pro Ser Ser Phe Leu Pro Phe Ser Pro Thr Gly Pro Leu Leu
        1715                1720                1725            
Leu Gly Cys Cys Glu Thr Pro Val Val Ser Leu Ala Glu Ala Gln Gln
    1730                1735                1740                
Glu Leu Gln Met Leu Gln Lys Gln Leu Gly Glu Ser Ala Ser Thr Val
1745                1750                1755                1760
Pro Pro Ala Ser Thr Ala Thr Leu Leu Ser Asn Asp Leu Glu Ala Asp
                1765                1770                1775    
Ser Ser Tyr Tyr Leu Asn Ser Ala Gln Pro His Ser Pro Pro Arg Gly
            1780                1785                1790        
Thr Ile Glu Leu Gly Arg Ile Leu Glu Pro Gly Tyr Leu Gly Ser Ser
        1795                1800                1805            
Gly Lys Trp Asp Val Met Arg Pro Gln Lys Gly Ser Val Ser Gly Asp
    1810                1815                1820                
Leu Ser Ser Gly Ser Ser Val Tyr Gln Leu Asn Ser Lys Pro Thr Gly
1825                1830                1835                1840
Ala Asp Leu Leu Glu Glu His Leu Gly Glu Ile Arg Asn Leu Arg Gln
                1845                1850                1855    
Arg Leu Glu Glu Ser Ile Cys Ile Asn Asp Arg Leu Arg Glu Gln Leu
            1860                1865                1870        
Glu His Arg Leu Thr Ser Thr Ala Arg Gly Arg Gly Ser Thr Ser Asn
        1875                1880                1885            
Phe Tyr Ser Gln Gly Leu Glu Ser Ile Pro Gln Leu Cys Asn Glu Asn
    1890                1895                1900                
Arg Val Leu Arg Glu Asp Asn Arg Arg Leu Gln Ala Gln Leu Ser His
1905                1910                1915                1920
Val Ser Arg Glu His Ser Gln Glu Thr Glu Ser Leu Arg Glu Ala Leu
                1925                1930                1935    
Leu Ser Ser Arg Ser His Leu Gln Glu Leu Glu Lys Glu Leu Glu His
            1940                1945                1950        
Gln Lys Val Glu Arg Gln Gln Leu Leu Glu Asp Leu Arg Glu Lys Gln
        1955                1960                1965            
Gln Glu Val Leu His Phe Arg Glu Glu Arg Leu Ser Leu Gln Glu Asn
    1970                1975                1980                
Asp Ser Arg Leu Gln His Lys Leu Val Leu Leu Gln Gln Gln Cys Glu
1985                1990                1995                2000
Glu Lys Gln Gln Leu Phe Glu Ser Leu Gln Ser Glu Leu Gln Ile Tyr
                2005                2010                2015    
Glu Ala Leu Tyr Gly Asn Ser Lys Lys Gly Leu Lys Ala Tyr Ser Leu
            2020                2025                2030        
Asp Ala Cys His Gln Ile Pro Leu Ser Ser Asp Leu Ser His Leu Val
        2035                2040                2045            
Ala Glu Val Arg Ala Leu Arg Gly Gln Leu Glu Gln Ser Ile Gln Gly
    2050                2055                2060                
Asn Asn Cys Leu Arg Leu Gln Leu Gln Gln Gln Leu Glu Ser Gly Ala
2065                2070                2075                2080
Gly Lys Ala Ser Leu Ser Pro Ser Ser Ile Asn Gln Asn Phe Pro Ala
                2085                2090                2095    
Ser Thr Asp Pro Gly Asn Lys Gln Leu Leu Leu Gln Asp Ser Ala Val
            2100                2105                2110        
Ser Pro Pro Val Arg Asp Val Gly Met Asn Ser Pro Ala Leu Val Phe
        2115                2120                2125            
Pro Ser Ser Ala Ser Ser Thr Pro Gly Ser Glu Thr Pro Ile Ile Asn
    2130                2135                2140                
Arg Ala Asn Gly Leu Gly Leu Asp Thr Ser Pro Val Met Lys Thr Pro
2145                2150                2155                2160
Pro Lys Leu Glu Gly Asp Ala Thr Asp Gly Ser Phe Ala Asn Lys His
                2165                2170                2175    
Gly Arg His Val Ile Gly His Ile Asp Asp Tyr Ser Ala Leu Arg Gln
            2180                2185                2190        
Gln Ile Ala Glu Gly Lys Leu Leu Val Lys Lys Ile Val Ser Leu Val
        2195                2200                2205            
Arg Ser Ala Cys Ser Phe Pro Gly Leu Glu Ala Gln Gly Thr Glu Val
    2210                2215                2220                
Leu Gly Ser Lys Gly Ile His Glu Leu Arg Ser Ser Thr Ser Ala Leu
2225                2230                2235                2240
His His Ala Leu Glu Glu Ser Ala Ser Leu Leu Thr Met Phe Trp Arg
                2245                2250                2255    
Ala Ala Leu Pro Ser Thr His Ile Pro Val Leu Pro Gly Lys Val Gly
            2260                2265                2270        
Glu Ser Thr Glu Arg Glu Leu Leu Glu Leu Arg Thr Lys Val Ser Lys
        2275                2280                2285            
Gln Glu Arg Leu Leu Gln Ser Thr Thr Glu His Leu Lys Asn Ala Asn
    2290                2295                2300                
Gln Gln Lys Glu Ser Met Glu Gln Phe Ile Val Ser Gln Leu Thr Arg
2305                2310                2315                2320
Thr His Asp Val Leu Lys Lys Ala Arg Thr Asn Leu Glu Val Lys Ser
                2325                2330                2335    
Leu Arg Ala Leu Pro Cys Thr Pro Ala Leu
            2340                2345    


<210> 3
<211> 3963
<212> DNA
<213> homo sapiens

<400> 3
ggtcgggagg ggcgggaact ggggagtttc gccaatcggt gcagactccg gttctcccca 60
accccgggcc tgggcagctg ggcactgggg cgccgttccc cacccggcgc ggacttcgga 120
accggccctg ggactgactg gctctaccac tcgagcgcgt ctccgctgga cccggaaccc 180
cggtcggtcc attccccgcg aagatgcgcg ccctggcggc cctgagcgcg cccccgaacg 240
agcggctcct tccccgggac cccgcggcta cccgggaccc cgacgccgcg cggccggcgc 300
gcaggagcgc agtggagagg ctggcggcgg atcgcgccaa gtatgtgcgg ggtcggccgg 360
ggactggccg gggcgtcgct tccgagggca gcggcccggg ggcgatcaag tgcccgggga 420
acgaccctgg gcccccggcc cgcgccccgg ccccggtggc gcgcagggct attgcgcgga 480
agccgttgag accggactcg ctgatcatct accggcagaa atgcgaattc gtgcgaggat 540
cgggcgccga cggccccagg gcaagcctgg tgaagaagct cttccagggg ccgggtaagg 600
acaaggcgcc ggtgccccgg acgggagacg agggcaaggc cgggaacccg gagacggtcc 660
cgaccactcc tggccccgcg gcggaccccg caatccccga gaccccagcc ccagccgcgc 720
ggtccgcggc gccctccagt gtcccggccg cgccccctgg gccagagccg cgggtggtga 780
ggcgtcgggg gctgcagcgc tcacagtcgg acctcagctc ccgctattcc gctgccttgg 840
ccgagtctga caccttcttc cagtactgcg gcctggaccc cgaggtggtg gaggccctgg 900
ggagggagaa cttcaccgcg gggtcggact gtgtgaccct caaggtgcgc agcgtgagcg 960
tcgccacctc cggcagcggc ttctcccggc acagcggcgg cgacgacgag gggctgcagg 1020
aggaggagct gatagagcag gtgcccagca ccacttcggt catcgagagg aacgcccgca 1080
tcatcaagtg gctgtacacc tgtaagaagg ccaaggagac ccccagccag gagcagagcc 1140
ggacccgagg aagcaaacct tcccgatgat gaagacttct tgaaggattt catgggtgat 1200
ttgggatccc aggaccattt ggctagtgtg cctaggtgac cacatgattg ctgttttacc 1260
aggaatgcag catcccattg acaaaacaag tgctctgaga aggtttaaaa tactacagag 1320
aatatgggaa cacagacctt gaaatttagc tgagttgtaa cagctgaaac tccaagaggt 1380
gtcttccttg tttgaggtga aactagtgtt gcttccagag ggcagctgga aaccgtaaag 1440
ctgtttggaa atctttttga ctgacttgct gacaaagagg tactgtgatg cattttaaca 1500
atatctaagt tgattttttt ttaaatcaag gaaaataaaa accaagcatg aatgctatgg 1560
tatgtgcccc ttttgaccat cctgggctga ttaacatcat ttaaatcaaa gtaatcataa 1620
aaaggcatat tctacttcaa ttatgtggtc aaataagagt aaacacacac actcacacat 1680
gctgacccca attgccagag cattactgca ctataaatta cggttaattc ccaaattata 1740
ctactgttta tcttatttaa caagtcagaa agcactttta aaataacttg agggctacaa 1800
ggtcattcta ttaatgtcat tctccattcg ggttgtaggc atgtggaagt acccattaaa 1860
agataagtta gagtttaaat actgataaac aaaacctttt attgcaactg gacagtttct 1920
ggagagttag cggaagaatc ttggagtttc ctttggtcag atgaatacaa catttcactt 1980
ttgcagcact atttagaatg tactccatgg ttctcttgtt cccaacttcc aaaaagaaca 2040
gaaaactttg gtttacacag aacacgggca tctgaggcag gacctcttcc ctgccctttg 2100
atctgactca cacctccaca tatgacgtaa tcaacccaaa tttgacacca attcactctt 2160
ttctgcaaag ggcatatttt gaaacaaggg acagcctgag ggcggctata atgagaatgt 2220
tcatgggggt tactgggtcc ctaattctga acttgcttat gacacccaga gtgaatagat 2280
tcagattcag aaccttctga gaaataaccc aaagaaaatt tgttacccag ccaattcttc 2340
gaaagcttaa tatcaaaata tatcttttca agaagaaaat cgttagagag aagaatgtgg 2400
aggggagaga aatgggtttc tcattgatat gatattttgt taaccatttc attttgaatt 2460
attcaagttt tggttaatat tgtattcttt tttcgtaact attttaccgt gagagtaggt 2520
cattgggtta cttagatatt tatttttaca cagttattag tcttcagata gttttatttt 2580
acttcatatg attttagttt ttgtcagtat aattttaaat catgtttttc ttggtcatct 2640
ctttgtgtat attgtgtaat tggattttca ttgactgcaa gtggagtgtt tgccactcaa 2700
ttcagtactc agtactatgg tgacttgttt tcaaataagt ctcagataca catttaggga 2760
gcctttgctg gccgaatata gactctgtca ggacagcagg tcccctgatc taagaatttt 2820
ccccaatggt tgctctaaaa atgctgctat tttgctgttc actgtattgc acttagttaa 2880
aaagaagata atgtgaaaga tgagagcagt tttttaaagg atcttttcat atacccaatt 2940
cccttatttt cagatgtccc atcaatttta gatatgaaag ctttaagtaa aagtgtgtat 3000
gcctttctac tgtcagaaca ggatggatgc agcctgggtc agatttattt aagataaaaa 3060
tcatgcagac tcatcattca tatcataggt gaaaaatgta aaaaccaaat ggtttccact 3120
aaagccacca agatctttta gaaatgtttg cacctttggt ggtggcacag gaaaagagaa 3180
gaattcagct ggagtgaatt ctagaagtag atatcagaaa cggggcatga agaacagggg 3240
aactgggtgg catcagactc ctaaagaagt gagttaattt tccttccctt ccattcagat 3300
tcatgccaca gctccatatc ttgagtatgt gtaagaggtg agttccttct tcagccaggg 3360
gcggtggctc atgcctttaa tcccaatgct ttgggaggcc aaggtgggag gatcacttgt 3420
gccttggggt tcaaggttgc agtgaaccat gattgcacca ctgcactcca gcctgagtga 3480
cagagcaaga ccctgtctct aaaaatatat ataaaaagta aaactaaaga acttcttgcc 3540
taaacctgaa ttaccgcaat ttgctgagtg actttgagaa aaatcagact gtttagttca 3600
gtcgggatga aaagcttgcg attgcttccc acaagaatgg gcaatagtga cggctgcaag 3660
gtacttttat ttgttcatga aagaacgaca atttttcaaa atgtaattaa acataataga 3720
atgttttaaa ctactgggca ctgaaactgg aagaaaaagg aggctttatt gaacattccc 3780
ctttttcagt tggttcaaag ttcagcactg tggttatcat tggtgatgcc agaaaacatt 3840
agtagactta gacaattgct atggcagttt ctaaacagag ctttttctat acactatttg 3900
caactggagt gcaatattgt atattctgtg ttaaagaaat aaagtatttt tatcatttat 3960
taa                                                               3963

<210> 4
<211> 321
<212> PRT
<213> homo sapiens

<400> 4
Met Arg Ala Leu Ala Ala Leu Ser Ala Pro Pro Asn Glu Arg Leu Leu
 1               5                  10                  15      
Pro Arg Asp Pro Ala Ala Thr Arg Asp Pro Asp Ala Ala Arg Pro Ala
            20                  25                  30          
Arg Arg Ser Ala Val Glu Arg Leu Ala Ala Asp Arg Ala Lys Tyr Val
        35                  40                  45              
Arg Gly Arg Pro Gly Thr Gly Arg Gly Val Ala Ser Glu Gly Ser Gly
    50                  55                  60                  
Pro Gly Ala Ile Lys Cys Pro Gly Asn Asp Pro Gly Pro Pro Ala Arg
65                  70                  75                  80  
Ala Pro Ala Pro Val Ala Arg Arg Ala Ile Ala Arg Lys Pro Leu Arg
                85                  90                  95      
Pro Asp Ser Leu Ile Ile Tyr Arg Gln Lys Cys Glu Phe Val Arg Gly
            100                 105                 110         
Ser Gly Ala Asp Gly Pro Arg Ala Ser Leu Val Lys Lys Leu Phe Gln
        115                 120                 125             
Gly Pro Gly Lys Asp Lys Ala Pro Val Pro Arg Thr Gly Asp Glu Gly
    130                 135                 140                 
Lys Ala Gly Asn Pro Glu Thr Val Pro Thr Thr Pro Gly Pro Ala Ala
145                 150                 155                 160 
Asp Pro Ala Ile Pro Glu Thr Pro Ala Pro Ala Ala Arg Ser Ala Ala
                165                 170                 175     
Pro Ser Ser Val Pro Ala Ala Pro Pro Gly Pro Glu Pro Arg Val Val
            180                 185                 190         
Arg Arg Arg Gly Leu Gln Arg Ser Gln Ser Asp Leu Ser Ser Arg Tyr
        195                 200                 205             
Ser Ala Ala Leu Ala Glu Ser Asp Thr Phe Phe Gln Tyr Cys Gly Leu
    210                 215                 220                 
Asp Pro Glu Val Val Glu Ala Leu Gly Arg Glu Asn Phe Thr Ala Gly
225                 230                 235                 240 
Ser Asp Cys Val Thr Leu Lys Val Arg Ser Val Ser Val Ala Thr Ser
                245                 250                 255     
Gly Ser Gly Phe Ser Arg His Ser Gly Gly Asp Asp Glu Gly Leu Gln
            260                 265                 270         
Glu Glu Glu Leu Ile Glu Gln Val Pro Ser Thr Thr Ser Val Ile Glu
        275                 280                 285             
Arg Asn Ala Arg Ile Ile Lys Trp Leu Tyr Thr Cys Lys Lys Ala Lys
    290                 295                 300                 
Glu Thr Pro Ser Gln Glu Gln Ser Arg Thr Arg Gly Ser Lys Pro Ser
305                 310                 315                 320 
Arg
    


<210> 5
<211> 3922
<212> DNA
<213> homo sapiens

<400> 5
atcagagcag ctggcagcgc ggcgggcagc gtttgccgag cgggcgctcc gggtcgcacg 60
caagtccgcg cggggtccgg gccacgcacg cggtttcatc gccatcccca gccgggccac 120
gcgcgcaggc agacaagctg ttcgcggcga ccggagagcg ccgacaccat gtggatccag 180
gttcggacca tggacgggag gcagacccac acggtggact cgctgtccag gctgaccaag 240
gtggaggagc tgaggcggaa gatccaggag ctgttccacg tggagccagg cctgcagagg 300
ctgttctaca ggggcaaaca gatggaggac ggccataccc tcttcgacta cgaggtccgc 360
ctgaatgaca ccatccagct cctggtccgc cagagcctcg tgctccccca cagcaccaag 420
gagcgggact ccgagctctc cgacaccgac tccggctgct gcctgggcca gagtgagtca 480
gacaagtcct ccacccacgg tgaggcggcc gccgagactg acagcaggcc agccgatgag 540
gacatgtggg atgagacgga attggggctg tacaaggtca atgagtacgt cgatgctcgg 600
gacacgaaca tgggggcgtg gtttgaggcg caggtggtca gggtgacgcg gaaggccccc 660
tcccgggacg agccctgcag ctccacgtcc aggccggcgc tggaggagga cgtcatttac 720
cacgtgaaat acgacgacta cccggagaac ggcgtggtcc agatgaactc cagggacgtc 780
cgagcgcgcg cccgcaccat catcaagtgg caggacctgg aggtgggcca ggtggtcatg 840
ctcaactaca accccgacaa ccccaaggag cggggcttct ggtacgacgc ggagatctcc 900
aggaagcgcg agaccaggac ggcgcgggaa ctctacgcca acgtggtgct gggggatgat 960
tctctgaacg actgtcggat catcttcgtg gacgaagtct tcaagattga gcggccgggt 1020
gaagggagcc ccatggttga caaccccatg agacggaaga gcgggccgtc ctgcaagcac 1080
tgcaaggacg acgtgaacag actctgccgg gtctgcgcct gccacctgtg cgggggccgg 1140
caggaccccg acaagcagct catgtgcgat gagtgcgaca tggccttcca catctactgc 1200
ctggacccgc ccctcagcag tgttcccagc gaggacgagt ggtactgccc tgagtgccgg 1260
aatgatgcca gcgaggtggt actggcggga gagcggctga gagagagcaa gaagaaggcg 1320
aagatggcct cggccacatc gtcctcacag cgggactggg gcaagggcat ggcctgtgtg 1380
ggccgcacca aggaatgtac catcgtcccg tccaaccact acggacccat cccggggatc 1440
cccgtgggca ccatgtggcg gttccgagtc caggtcagcg agtcgggtgt ccatcggccc 1500
cacgtggctg gcatacacgg ccggagcaac gacggagcgt actccctagt cctggcgggg 1560
ggctatgagg atgatgtgga ccatgggaat tttttcacat acacgggtag tggtggtcga 1620
gatctttccg gcaacaagag gaccgcggaa cagtcttgtg atcagaaact caccaacacc 1680
aacagggcgc tggctctcaa ctgctttgct cccatcaatg accaagaagg ggccgaggcc 1740
aaggactggc ggtcggggaa gccggtcagg gtggtgcgca atgtcaaggg tggcaagaat 1800
agcaagtacg cccccgctga gggcaaccgc tacgatggca tctacaaggt tgtgaaatac 1860
tggcccgaga aggggaagtc cgggtttctc gtgtggcgct accttctgcg gagggacgat 1920
gatgagcctg gcccttggac gaaggagggg aaggaccgga tcaagaagct ggggctgacc 1980
atgcagtatc cagaaggcta cctggaagcc ctggccaacc gagagcgaga gaaggagaac 2040
agcaagaggg aggaggagga gcagcaggag gggggcttcg cgtcccccag gacgggcaag 2100
ggcaagtgga agcggaagtc ggcaggaggt ggcccgagca gggccgggtc cccgcgccgg 2160
acatccaaga aaaccaaggt ggagccctac agtctcacgg cccagcagag cagcctcatc 2220
agagaggaca agagcaacgc caagctgtgg aatgaggtcc tggcgtcact caaggaccgg 2280
ccggcgagcg gcagcccgtt ccagttgttc ctgagtaaag tggaggagac gttccagtgt 2340
atctgctgtc aggagctggt gttccggccc atcacgaccg tgtgccagca caacgtgtgc 2400
aaggactgcc tggacagatc ctttcgggca caggtgttca gctgccctgc ctgccgctac 2460
gacctgggcc gcagctatgc catgcaggtg aaccagcctc tgcagaccgt cctcaaccag 2520
ctcttccccg gctacggcaa tggccggtga tctccaagca cttctcgaca ggcgttttgc 2580
tgaaaacgtg tcggagggct cgttcatcgg cactgatttt gttcttagtg ggcttaactt 2640
aaacaggtag tgtttcctcc gttccctaaa aaggtttgtc ttcctttttt tttttatttt 2700
tatttttcaa atctatacat tttcaggaat ttatgtattc tggctaaaag ttggacttct 2760
cagtattgtg tttagttctt tgaaaacata aaagcctgca atttctcgac aaaacaacac 2820
aagatttttt aaagatggaa tcagaaacta cgtggtgtgg aggctgttga tgtttctggt 2880
gtcaagttct cagaagttgc tgccaccaac tctttaagaa ggcgacagga tcagtccttc 2940
tctcgggttc tggcccccaa ggtcagagca agcatcttcc tgacagcatt ttgtcatcta 3000
aagtccagtg acatggttcc ccgtggtggc ccgtggcagc ccgtggcatg gcgtggctca 3060
gctgtctgtt gaagttgttg caaggaaaag aggaaacatc tcgggcctag ttcaaacctt 3120
tgcctcaaag ccatccccca ccagactgct tagcgtctga gatccgcgtg aaaagtcctc 3180
tgcccacgag agcagggagt tggggccacg cagaaatggc ctcaagggga ctctgctcca 3240
cgtggggcca ggcgtgtgac tgacgctgtc cgacgaaggc ggccacggac ggacgccagc 3300
acacgaagtc acgtgcaagt gcctttgatt cgttccttct ttctaaagac gacagtcttt 3360
gttgttagca ctgaattatt gaaaatgtca accagattct agaaactgcg gtcatccagt 3420
tcttcctgac accggatggg tgcttgggaa ccgtttgagc cttatagatc atttacattc 3480
aattttttta actcagcaag tgagaactta caagagggtt tttttaaaat ttttttttct 3540
cttaatgaac acattttcta aatgaatttt ttttgtagtt actgtatatg taccaagaaa 3600
gatataacgt tagggtttgg ttgtttttgt ttttgtattt tttttctttt gaaagggttt 3660
gttaattttt ctaattttac caaagtttgc agcctatacc tcaataaaac agggatattt 3720
taaatcacat acctgcagac aaactggagc aatgttattt ttaaagggtt tttttcacct 3780
ccttattctt agattattaa tgtattaggg aagaatgaga caattttgtg taggcttttt 3840
ctaaagtcca gtactttgtc cagattttag attctcagaa taaatgtttt tcacagatag 3900
aaaaaaaaaa aaaaaaaaaa aa                                          3922

<210> 6
<211> 793
<212> PRT
<213> homo sapiens

<400> 6
Met Trp Ile Gln Val Arg Thr Met Asp Gly Arg Gln Thr His Thr Val
 1               5                  10                  15      
Asp Ser Leu Ser Arg Leu Thr Lys Val Glu Glu Leu Arg Arg Lys Ile
            20                  25                  30          
Gln Glu Leu Phe His Val Glu Pro Gly Leu Gln Arg Leu Phe Tyr Arg
        35                  40                  45              
Gly Lys Gln Met Glu Asp Gly His Thr Leu Phe Asp Tyr Glu Val Arg
    50                  55                  60                  
Leu Asn Asp Thr Ile Gln Leu Leu Val Arg Gln Ser Leu Val Leu Pro
65                  70                  75                  80  
His Ser Thr Lys Glu Arg Asp Ser Glu Leu Ser Asp Thr Asp Ser Gly
                85                  90                  95      
Cys Cys Leu Gly Gln Ser Glu Ser Asp Lys Ser Ser Thr His Gly Glu
            100                 105                 110         
Ala Ala Ala Glu Thr Asp Ser Arg Pro Ala Asp Glu Asp Met Trp Asp
        115                 120                 125             
Glu Thr Glu Leu Gly Leu Tyr Lys Val Asn Glu Tyr Val Asp Ala Arg
    130                 135                 140                 
Asp Thr Asn Met Gly Ala Trp Phe Glu Ala Gln Val Val Arg Val Thr
145                 150                 155                 160 
Arg Lys Ala Pro Ser Arg Asp Glu Pro Cys Ser Ser Thr Ser Arg Pro
                165                 170                 175     
Ala Leu Glu Glu Asp Val Ile Tyr His Val Lys Tyr Asp Asp Tyr Pro
            180                 185                 190         
Glu Asn Gly Val Val Gln Met Asn Ser Arg Asp Val Arg Ala Arg Ala
        195                 200                 205             
Arg Thr Ile Ile Lys Trp Gln Asp Leu Glu Val Gly Gln Val Val Met
    210                 215                 220                 
Leu Asn Tyr Asn Pro Asp Asn Pro Lys Glu Arg Gly Phe Trp Tyr Asp
225                 230                 235                 240 
Ala Glu Ile Ser Arg Lys Arg Glu Thr Arg Thr Ala Arg Glu Leu Tyr
                245                 250                 255     
Ala Asn Val Val Leu Gly Asp Asp Ser Leu Asn Asp Cys Arg Ile Ile
            260                 265                 270         
Phe Val Asp Glu Val Phe Lys Ile Glu Arg Pro Gly Glu Gly Ser Pro
        275                 280                 285             
Met Val Asp Asn Pro Met Arg Arg Lys Ser Gly Pro Ser Cys Lys His
    290                 295                 300                 
Cys Lys Asp Asp Val Asn Arg Leu Cys Arg Val Cys Ala Cys His Leu
305                 310                 315                 320 
Cys Gly Gly Arg Gln Asp Pro Asp Lys Gln Leu Met Cys Asp Glu Cys
                325                 330                 335     
Asp Met Ala Phe His Ile Tyr Cys Leu Asp Pro Pro Leu Ser Ser Val
            340                 345                 350         
Pro Ser Glu Asp Glu Trp Tyr Cys Pro Glu Cys Arg Asn Asp Ala Ser
        355                 360                 365             
Glu Val Val Leu Ala Gly Glu Arg Leu Arg Glu Ser Lys Lys Lys Ala
    370                 375                 380                 
Lys Met Ala Ser Ala Thr Ser Ser Ser Gln Arg Asp Trp Gly Lys Gly
385                 390                 395                 400 
Met Ala Cys Val Gly Arg Thr Lys Glu Cys Thr Ile Val Pro Ser Asn
                405                 410                 415     
His Tyr Gly Pro Ile Pro Gly Ile Pro Val Gly Thr Met Trp Arg Phe
            420                 425                 430         
Arg Val Gln Val Ser Glu Ser Gly Val His Arg Pro His Val Ala Gly
        435                 440                 445             
Ile His Gly Arg Ser Asn Asp Gly Ala Tyr Ser Leu Val Leu Ala Gly
    450                 455                 460                 
Gly Tyr Glu Asp Asp Val Asp His Gly Asn Phe Phe Thr Tyr Thr Gly
465                 470                 475                 480 
Ser Gly Gly Arg Asp Leu Ser Gly Asn Lys Arg Thr Ala Glu Gln Ser
                485                 490                 495     
Cys Asp Gln Lys Leu Thr Asn Thr Asn Arg Ala Leu Ala Leu Asn Cys
            500                 505                 510         
Phe Ala Pro Ile Asn Asp Gln Glu Gly Ala Glu Ala Lys Asp Trp Arg
        515                 520                 525             
Ser Gly Lys Pro Val Arg Val Val Arg Asn Val Lys Gly Gly Lys Asn
    530                 535                 540                 
Ser Lys Tyr Ala Pro Ala Glu Gly Asn Arg Tyr Asp Gly Ile Tyr Lys
545                 550                 555                 560 
Val Val Lys Tyr Trp Pro Glu Lys Gly Lys Ser Gly Phe Leu Val Trp
                565                 570                 575     
Arg Tyr Leu Leu Arg Arg Asp Asp Asp Glu Pro Gly Pro Trp Thr Lys
            580                 585                 590         
Glu Gly Lys Asp Arg Ile Lys Lys Leu Gly Leu Thr Met Gln Tyr Pro
        595                 600                 605             
Glu Gly Tyr Leu Glu Ala Leu Ala Asn Arg Glu Arg Glu Lys Glu Asn
    610                 615                 620                 
Ser Lys Arg Glu Glu Glu Glu Gln Gln Glu Gly Gly Phe Ala Ser Pro
625                 630                 635                 640 
Arg Thr Gly Lys Gly Lys Trp Lys Arg Lys Ser Ala Gly Gly Gly Pro
                645                 650                 655     
Ser Arg Ala Gly Ser Pro Arg Arg Thr Ser Lys Lys Thr Lys Val Glu
            660                 665                 670         
Pro Tyr Ser Leu Thr Ala Gln Gln Ser Ser Leu Ile Arg Glu Asp Lys
        675                 680                 685             
Ser Asn Ala Lys Leu Trp Asn Glu Val Leu Ala Ser Leu Lys Asp Arg
    690                 695                 700                 
Pro Ala Ser Gly Ser Pro Phe Gln Leu Phe Leu Ser Lys Val Glu Glu
705                 710                 715                 720 
Thr Phe Gln Cys Ile Cys Cys Gln Glu Leu Val Phe Arg Pro Ile Thr
                725                 730                 735     
Thr Val Cys Gln His Asn Val Cys Lys Asp Cys Leu Asp Arg Ser Phe
            740                 745                 750         
Arg Ala Gln Val Phe Ser Cys Pro Ala Cys Arg Tyr Asp Leu Gly Arg
        755                 760                 765             
Ser Tyr Ala Met Gln Val Asn Gln Pro Leu Gln Thr Val Leu Asn Gln
    770                 775                 780                 
Leu Phe Pro Gly Tyr Gly Asn Gly Arg
785                 790             


<210> 7
<211> 4093
<212> DNA
<213> homo sapiens

<400> 7
gtgagagagt gagcgagaca gaaagagaga gaagtgcacc agcgagccgg ggcaggaaga 60
ggaggtttcg ccaccggagc ggcccggcga cgcgctgaca gcttcccctg cccttcccgt 120
cggtcgggcc gccagccgcc gcagccctcg gcctgcacgc agccaccggc cccgctcccg 180
gagcccagcg ccgccgaggc cgcagccgcc cggccagtaa ggcggcgccg ccgcccggcc 240
accgcgcgcc ctgcgcttcc ctccgcccgc gctgcggcca tggcgcggcg ctgactggcc 300
tggcccggcc ccgccgcgct cccgctcgcc ccgacccgca ctcgggcccg cccgggctcc 360
ggcctgccgc cgcctcttcc ttctccagcc ggcaggcccg cgccgcttag gagggagagc 420
ccacccgcgc caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg 480
atccatattt gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa 540
tatttaatcc agaagtattt caaccacaga tggcactgcc aacagcagat ggcccatacc 600
ttcaaatatt agagcaacct aaacagagag gatttcgttt ccgttatgta tgtgaaggcc 660
catcccatgg tggactacct ggtgcctcta gtgaaaagaa caagaagtct taccctcagg 720
tcaaaatctg caactatgtg ggaccagcaa aggttattgt tcagttggtc acaaatggaa 780
aaaatatcca cctgcatgcc cacagcctgg tgggaaaaca ctgtgaggat gggatctgca 840
ctgtaactgc tggacccaag gacatggtgg tcggcttcgc aaacctgggt atacttcatg 900
tgacaaagaa aaaagtattt gaaacactgg aagcacgaat gacagaggcg tgtataaggg 960
gctataatcc tggactcttg gtgcaccctg accttgccta tttgcaagca gaaggtggag 1020
gggaccggca gctgggagat cgggaaaaag agctaatccg ccaagcagct ctgcagcaga 1080
ccaaggagat ggacctcagc gtggtgcggc tcatgtttac agcttttctt ccggatagca 1140
ctggcagctt cacaaggcgc ctggaacccg tggtatcaga cgccatctat gacagtaaag 1200
cccccaatgc atccaacttg aaaattgtaa gaatggacag gacagctgga tgtgtgactg 1260
gaggggagga aatttatctt ctttgtgaca aagttcagaa agatgacatc cagattcgat 1320
tttatgaaga ggaagaaaat ggtggagtct gggaaggatt tggagatttt tcccccacag 1380
atgttcatag acaatttgcc attgtcttca aaactccaaa gtataaagat attaatatta 1440
caaaaccagc ctctgtgttt gtccagcttc ggaggaaatc tgacttggaa actagtgaac 1500
caaaaccttt cctctactat cctgaaatca aagataaaga agaagtgcag aggaaacgtc 1560
agaagctcat gcccaatttt tcggatagtt tcggcggtgg tagtggtgct ggagctggag 1620
gcggaggcat gtttggtagt ggcggtggag gagggggcac tggaagtaca ggtccagggt 1680
atagcttccc acactatgga tttcctactt atggtgggat tactttccat cctggaacta 1740
ctaaatctaa tgctgggatg aagcatggaa ccatggacac tgaatctaaa aaggaccctg 1800
aaggttgtga caaaagtgat gacaaaaaca ctgtaaacct ctttgggaaa gttattgaaa 1860
ccacagagca agatcaggag cccagcgagg ccaccgttgg gaatggtgag gtcactctaa 1920
cgtatgcaac aggaacaaaa gaagagagtg ctggagttca ggataacctc tttctagaga 1980
aggctatgca gcttgcaaag aggcatgcca atgccctttt cgactacgcg gtgacaggag 2040
acgtgaagat gctgctggcc gtccagcgcc atctcactgc tgtgcaggat gagaatgggg 2100
acagtgtctt acacttagca atcatccacc ttcattctca acttgtgagg gatctactag 2160
aagtcacatc tggtttgatt tctgatgaca ttatcaacat gagaaatgat ctgtaccaga 2220
cgcccttgca cttggcagtg atcactaagc aggaagatgt ggtggaggat ttgctgaggg 2280
ctggggccga cctgagcctt ctggaccgct tgggtaactc tgttttgcac ctagctgcca 2340
aagaaggaca tgataaagtt ctcagtatct tactcaagca caaaaaggca gcactacttc 2400
ttgaccaccc caacggggac ggtctgaatg ccattcatct agccatgatg agcaatagcc 2460
tgccatgttt gctgctgctg gtggccgctg gggctgacgt caatgctcag gagcagaagt 2520
ccgggcgcac agcactgcac ctggctgtgg agcacgacaa catctcattg gcaggctgcc 2580
tgctcctgga gggtgatgcc catgtggaca gtactaccta cgatggaacc acacccctgc 2640
atatagcagc tgggagaggg tccaccaggc tggcagctct tctcaaagca gcaggagcag 2700
atcccctggt ggagaacttt gagcctctct atgacctgga tgactcttgg gaaaatgcag 2760
gagaggatga aggagttgtg cctggaacca cgcctctaga tatggccacc agctggcagg 2820
tatttgacat attaaatggg aaaccatatg agccagagtt tacatctgat gatttactag 2880
cacaaggaga catgaaacag ctggctgaag atgtgaagct gcagctgtat aagttactag 2940
aaattcctga tccagacaaa aactgggcta ctctggcgca gaaattaggt ctggggatac 3000
ttaataatgc cttccggctg agtcctgctc cttccaaaac acttatggac aactatgagg 3060
tctctggggg tacagtcaga gagctggtgg aggccctgag acaaatgggc tacaccgaag 3120
caattgaagt gatccaggca gcctccagcc cagtgaagac cacctctcag gcccactcgc 3180
tgcctctctc gcctgcctcc acaaggcagc aaatagacga gctccgagac agtgacagtg 3240
tctgcgacag cggcgtggag acatccttcc gcaaactcag ctttaccgag tctctgacca 3300
gtggtgcctc actgctaact ctcaacaaaa tgccccatga ttatgggcag gaaggacctc 3360
tagaaggcaa aatttagcct gctgacaatt tcccacaccg tgtaaaccaa agccctaaaa 3420
ttccactgcg ttgtccacaa gacagaagct gaagtgcatc caaaggtgct cagagagccg 3480
gcccgcctga atcattctcg atttaactcg agaccttttc aacttggctt cctttcttgg 3540
ttcataaatg aattttagtt tggttcactt acagatagta tctagcaatc acaacactgg 3600
ctgagcggat gcatctgggg atgaggttgc ttactaagct ttgccagctg ctgctggatc 3660
acagctgctt tctgttgtca ttgctgttgt ccctctgcta cgttcctatt gtcattaaag 3720
gtatcacggt cgccacctgg cattccttct gaccacagca tcattttgca ttcaaattaa 3780
gggttaagaa aagagatatt ttaaaatgag agtcacttga tgtgccattt taaaaaaaaa 3840
ggcatattgc tttttctaat gtggttattt ctctgatttg caaaaaaaaa aaaaaaaaaa 3900
atacttgtca atatttaaac atggttacaa tcattgctga aaatggtatt ttcccccttt 3960
tctgcatttt gctattgtaa atatgttttt tagatcaaat actttaaagg aaaaaatgtt 4020
ggatttataa atgctatttt ttattttact tttataataa aaggaaaagc aaattgatga 4080
cctcaaaaaa aaa                                                    4093

<210> 8
<211> 969
<212> PRT
<213> homo sapiens

<400> 8
Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His
 1               5                  10                  15      
Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln
            20                  25                  30          
Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu
        35                  40                  45              
Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly
    50                  55                  60                  
Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys
65                  70                  75                  80  
Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val
                85                  90                  95      
Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His
            100                 105                 110         
Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala
        115                 120                 125             
Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His
    130                 135                 140                 
Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu
145                 150                 155                 160 
Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu
                165                 170                 175     
Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg
            180                 185                 190         
Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met
        195                 200                 205             
Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser
    210                 215                 220                 
Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile
225                 230                 235                 240 
Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met
                245                 250                 255     
Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu
            260                 265                 270         
Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu
        275                 280                 285             
Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr
    290                 295                 300                 
Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys
305                 310                 315                 320 
Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg
                325                 330                 335     
Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro
            340                 345                 350         
Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met
        355                 360                 365             
Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly
    370                 375                 380                 
Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser
385                 390                 395                 400 
Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly
                405                 410                 415     
Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys
            420                 425                 430         
His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp
        435                 440                 445             
Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu
    450                 455                 460                 
Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly
465                 470                 475                 480 
Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly
                485                 490                 495     
Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg
            500                 505                 510         
His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met
        515                 520                 525             
Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly
    530                 535                 540                 
Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val
545                 550                 555                 560 
Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile
                565                 570                 575     
Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile
            580                 585                 590         
Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp
        595                 600                 605             
Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala
    610                 615                 620                 
Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys
625                 630                 635                 640 
Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile
                645                 650                 655     
His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val
            660                 665                 670         
Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr
        675                 680                 685             
Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys
    690                 695                 700                 
Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly
705                 710                 715                 720 
Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala
                725                 730                 735     
Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu
            740                 745                 750         
Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu
        755                 760                 765             
Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln
    770                 775                 780                 
Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser
785                 790                 795                 800 
Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val
                805                 810                 815     
Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn
            820                 825                 830         
Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala
        835                 840                 845             
Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu
    850                 855                 860                 
Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met
865                 870                 875                 880 
Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val
                885                 890                 895     
Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr
            900                 905                 910         
Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser
        915                 920                 925             
Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr
    930                 935                 940                 
Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly
945                 950                 955                 960 
Gln Glu Gly Pro Leu Glu Gly Lys Ile
                965                 


<210> 9
<211> 2696
<212> DNA
<213> homo sapiens

<400> 9
agcttcgagg gaccgcccgg aaagacacaa cgcgcgtgga aggcgccggg cgtccagtct 60
cgggagagat tagaagtggc gctcctgccc agcgccggca atccagggga atccgcggcc 120
atcgcggatc caccaggggt gaggcggcac tgagcacaag tgtgaggctc tcgggagcta 180
cgcctccgct tccccagtgc cacccgtttt tacctcaggc ggttctgacc gccatcgttt 240
caacctggag aggtgagccc tcccctaccg acgcacttcc cttccccggc aggaaggagg 300
gcgctgaccc agcgggcgca cgcccctgac tgcgcatgcg ccgggtgcgc cgttcgtcag 360
cggcgagtgg cctcgcggcg ccggattcgt cgctccgcca agagtgcgcc tgcgcggtcg 420
ctggggctcg cacttcagct tcccctcccc cggcgccctc tggggctccg agcccggcgg 480
gaccatgttc accagcaccg gctccagtgg gctctacaag gcgcctctgt cgaagagcct 540
tctgctggtc cccagtgccc tctccctcct gctcgccctc ctcctgcctc actgccagaa 600
gctctttgtg tatgaccttc acgcagtcaa gaacgacttc cagatttgga ggttgatatg 660
tggaagaata atttgccttg atttgaaaga tactttctgc agtagtctgc ttatttataa 720
ttttaggata tttgaaagaa gatatggaag cagaaaattt gcatcctttt tgctgggttc 780
ctgggttttg tcagccttat ttgactttct cctcattgaa gctatgcagt atttctttgg 840
catcactgca gctagtaatt tgccttctgg attcctggca cctgtgtttg ctctgtttgt 900
accattttac tgctccatac caagagtcca agtggcacaa attctgggtc cgttgtccat 960
cacaaacaag acattgattt atatattggg actgcagctt ttcacctctg gttcctacat 1020
ctggattgta gccataagtg gacttatgtc cggtctgtgc tacgacagca aaatgttcca 1080
ggtgcatcag gtgctctgca tccccagctg gatggcaaaa ttcttttctt ggacacttga 1140
acccatcttc tcttcttcag aacccaccag cgaagccaga attgggatgg gagccacgct 1200
ggacatccag agacagcaga gaatggagct gctggaccgg cagctgatgt tctctcagtt 1260
tgcacaaggg aggcgacaga gacagcagca gggaggaatg atcaattgga atcgtctttt 1320
tcctccttta cgtcagcgac aaaacgtaaa ctatcagggc ggtcggcagt ctgagccagc 1380
agcgccccct ctagaagttt ctgaggaaca ggtcgcccgg ctcatggaga tgggattttc 1440
cagaggtgat gctttggaag ccctgagagc ttcaaacaat gacctcaatg tcgccaccaa 1500
cttcctgctg cagcactgat agtcccaggc caacactggg accggaccgg cagccgagtg 1560
acagtgcgtg gtccccacca tcagatcagc ccggggaccg agcatctctg gtgctgatgt 1620
tcttgtggga agagggaggt tccaccgcac ccctgccctc aaccgcaaga ctgttgccgt 1680
tttagtgtgg agataagttt gccattacat tagcatgtat tttctatcta tattttttat 1740
tgggcatttt ccctaggttg gagagtcagc actcgttttg aatgtgttta aaatgcatta 1800
aaatggaaga tttctgcagg cagttgaatg gcactccaga tggggaattg ctgtaaccct 1860
cttactgtaa catgtcatct cctgcgtcgt gatggggaga gggtaatgtt acttcacaaa 1920
ggacatgtca gatccttctt catggacttt tttagttact gttttttctc tcaaacttgt 1980
tttcgaatct cctgggagtg agggagaaac agggagctga atcctccccc aagctgttcc 2040
aggccagagg actctgcagt accttctcct acatctagta acaaagaatg gtgataacca 2100
tgcactggtt caaggttctg gagttctcca tgaaacttgg gttaattttg ctcagagtat 2160
ccagagttag ccactaggct gcgggtgaaa tgggatggag aagaacaaca gcaggcttcc 2220
tggagccaca tgggctgact agggcactct gtggctggcc tggcatgggc tcagcccagg 2280
aagaggagaa acgatccctt gcctgcccct ccctgtggca gggctaactg cctggccctc 2340
ctggctcgca gccagccagc cccctggcag caggttctcc tcagggcttg ggtcttcaac 2400
ctgtggcgac aggaggcagg gcagactgtg gaggacagga tgcaggtcag ggagagggaa 2460
ggcaggggtg gaccgccatg agcatgaaaa gacccgaagc aagttgactc ttgcaatgtg 2520
caactgttat gttctgcaaa atgagcaacg atgtatcaaa ttgatgcaaa tttagatgtt 2580
gatacttaca ataaagtttt taatgtgttt tactcttcag tatttttcta tcagacttgt 2640
acaaataaag ccttgttcca ggctatacat atttaccagt caaaaaaaaa aaaaaa     2696

<210> 10
<211> 344
<212> PRT
<213> homo sapiens

<400> 10
Met Phe Thr Ser Thr Gly Ser Ser Gly Leu Tyr Lys Ala Pro Leu Ser
 1               5                  10                  15      
Lys Ser Leu Leu Leu Val Pro Ser Ala Leu Ser Leu Leu Leu Ala Leu
            20                  25                  30          
Leu Leu Pro His Cys Gln Lys Leu Phe Val Tyr Asp Leu His Ala Val
        35                  40                  45              
Lys Asn Asp Phe Gln Ile Trp Arg Leu Ile Cys Gly Arg Ile Ile Cys
    50                  55                  60                  
Leu Asp Leu Lys Asp Thr Phe Cys Ser Ser Leu Leu Ile Tyr Asn Phe
65                  70                  75                  80  
Arg Ile Phe Glu Arg Arg Tyr Gly Ser Arg Lys Phe Ala Ser Phe Leu
                85                  90                  95      
Leu Gly Ser Trp Val Leu Ser Ala Leu Phe Asp Phe Leu Leu Ile Glu
            100                 105                 110         
Ala Met Gln Tyr Phe Phe Gly Ile Thr Ala Ala Ser Asn Leu Pro Ser
        115                 120                 125             
Gly Phe Leu Ala Pro Val Phe Ala Leu Phe Val Pro Phe Tyr Cys Ser
    130                 135                 140                 
Ile Pro Arg Val Gln Val Ala Gln Ile Leu Gly Pro Leu Ser Ile Thr
145                 150                 155                 160 
Asn Lys Thr Leu Ile Tyr Ile Leu Gly Leu Gln Leu Phe Thr Ser Gly
                165                 170                 175     
Ser Tyr Ile Trp Ile Val Ala Ile Ser Gly Leu Met Ser Gly Leu Cys
            180                 185                 190         
Tyr Asp Ser Lys Met Phe Gln Val His Gln Val Leu Cys Ile Pro Ser
        195                 200                 205             
Trp Met Ala Lys Phe Phe Ser Trp Thr Leu Glu Pro Ile Phe Ser Ser
    210                 215                 220                 
Ser Glu Pro Thr Ser Glu Ala Arg Ile Gly Met Gly Ala Thr Leu Asp
225                 230                 235                 240 
Ile Gln Arg Gln Gln Arg Met Glu Leu Leu Asp Arg Gln Leu Met Phe
                245                 250                 255     
Ser Gln Phe Ala Gln Gly Arg Arg Gln Arg Gln Gln Gln Gly Gly Met
            260                 265                 270         
Ile Asn Trp Asn Arg Leu Phe Pro Pro Leu Arg Gln Arg Gln Asn Val
        275                 280                 285             
Asn Tyr Gln Gly Gly Arg Gln Ser Glu Pro Ala Ala Pro Pro Leu Glu
    290                 295                 300                 
Val Ser Glu Glu Gln Val Ala Arg Leu Met Glu Met Gly Phe Ser Arg
305                 310                 315                 320 
Gly Asp Ala Leu Glu Ala Leu Arg Ala Ser Asn Asn Asp Leu Asn Val
                325                 330                 335     
Ala Thr Asn Phe Leu Leu Gln His
            340                 


<210> 11
<211> 4139
<212> DNA
<213> homo sapiens

<400> 11
agtgctcgcg gggccgcggc ggagtgtacc gtgctgctct actcgctgcc attcgcccgc 60
aggtcggcgc gctcgcccac ctgagccgcg ccggggctgc gggaccgtgg gacagcgcgc 120
tcagcccagc ctaggaaaga ggcagcagtc tcagcgcgga gatggggagc gggcgaagtt 180
gacgagtctc ccgcccacgc tgcgcccctc ctgcccagag gggctgcagc cagcggtctg 240
tcgcgcgtgc ctgtgtgccc gaggagccgc cccggggaga agacccggcg cggagttgtt 300
cccccaggga ggatccgcag cccagccgag ggggtcgggc ggcctggcta cgcaggaccc 360
agccccgcag ccgcggactc ccagcggcgg cgaagtttgg ctgctgagcg gcgcggcgcc 420
ggaccactgg acagcgggag cgatgcccgt ggggggcctg ttgccgctct tcagcagccc 480
cgcgggcggc gtcctgggcg gggggctcgg cggcggcggt ggcaggaagg ggtcgggccc 540
cgccgccctc cgcctgacgg agaagttcgt gctgctgctg gtattcagcg ccttcatcac 600
gctctgcttc ggggcgatct tcttcctgcc agactcctcc aagctgctca gcggggtcct 660
gttccactcc agccccgcct tgcagccggc cgccgaccac aagcccgggc ccggggcgcg 720
cgccgaggac gcggccgagg ggcgagcccg gcgccgcgag gagggggcac ccggggaccc 780
ggaggccgcc ctggaggaca acttggccag gatccgcgaa aaccacgagc gggctctcag 840
ggaagccaag gagaccctgc agaagctgcc cgaggagatc caaagagaca tcctactgga 900
gaagaagaag gtggcccagg accagctgcg tgacaaggcg ccgttcagag gcctgccccc 960
ggtggacttc gtgcccccaa tcggggtgga gagccgggag cccgccgacg ccgccatccg 1020
cgagaaaagg gcaaagatca aagagatgat gaaacatgct tggaataatt ataaaggtta 1080
tgcctgggga ttaaatgaac tcaaacctat atcaaaagga ggccattcaa gcagtttgtt 1140
tggtaacatc aaaggagcaa ctatagtaga tgccctggat acacttttta ttatggaaat 1200
gaaacatgaa tttgaagaag caaaatcatg ggttgaagaa aatttagatt ttaatgtgaa 1260
tgctgaaatt tctgtctttg aagtaaatat acgctttgtt ggtggactac tctcagccta 1320
ctatctgtct ggagaagaga tttttcgaaa gaaagcagtg gaacttgggg taaaattgct 1380
acctgcattt catactccct ctggaatacc ttgggcattg ctgaatatga aaagtggtat 1440
tggaaggaac tggccctggg cctctggagg cagcagtatt ctggcagaat ttggaaccct 1500
gcatttggag tttatgcact tgagccactt atcaggaaac cccatctttg ctgaaaaggt 1560
aatgaatatt cgaacagtac tgaacaaact ggaaaaacca caaggccttt atcctaacta 1620
tctgaatccc agtagtggac agtggggtca acatcatgta tcagttggag gacttggaga 1680
cagcttctat gagtatttgc tgaaggcctg gttaatgtct gacaagacag atctggaagc 1740
taagaagatg tattttgatg ctgttcaggc tatcgagact catttgatcc gcaagtctag 1800
cagcggacta acttatatcg cagagtggaa agggggcctc ctggagcaca agatgggcca 1860
cctgacctgc ttcgcggggg gcatgttcgc actcggggct gatgcagctc ccgaaggcat 1920
ggcccaacac taccttgaac tcggggctga aattgcccgt acttgtcatg aatcatataa 1980
tcgaacattt atgaaactgg gaccagaagc tttcagattt gatggtggtg ttgaagccat 2040
cgctacaaga caaaatgaaa aatactacat cttacggcca gaagttatgg agacttacat 2100
gtatatgtgg agactgactc atgatccaaa gtacaggaaa tgggcctggg aagccgtaga 2160
ggccttggaa aaccattgca gagtgaatgg aggctattca ggcctaaggg atgtttacct 2220
tcttcatgag agttatgatg atgtgcagca gagtttcttc ctggcagaga cattgaaata 2280
tttgtaccta atattttctg acgacgatct tcttccactg gagcattgga tcttcaatag 2340
cgaggcacat cttctcccta tcctccctaa agataaaaag gaagttgaaa tcagagagga 2400
ataaaaagac attttatatt ttattctgct ccattccctt cactgtatac cttaataatt 2460
ccttttctgg taatcaggca catgatgaac tttgattagt aggtctgtga ttaagttctt 2520
aaattgtttt gcagtctttt atgtttatta tcataggtat aggtggacct aaattcctta 2580
tcatatcctt tattaattca gccagtgtat ccaccagttt tttgtttatg tttttaagta 2640
acctattatc tctggatttc atgaaggtgt aatatcgttt ttgttaaact gaatagaatt 2700
gtatagcgat gacctcttaa ttataatttg atttgactgc aaaacttttt cctcctctaa 2760
gaggagatga tgtctgcttt aagctgtaat gttttgccat gttgcaaaaa gccataataa 2820
taagtataaa aaagcttttt cctttacaat ttcatgttaa tctggtttgt ctgtccacca 2880
gagacagatc ttctgtgaca gcctccttat gcaggtctat cattatttga tagaatgtct 2940
tctaaaatac ttcactcaca ttgtaattca aattagaaag tcattccaaa aggatcatgt 3000
catgttgacc tcatttcatc ggaactgcag tatatttttg ttggttaatt atattagtgt 3060
tttctatttt gtaaatgtgt cctttaattt tactttaaat gccctgtgtc atttctggat 3120
tatatactag ttaatttctt ccattcccta ctacacagag aggtgagctt tcaaattttg 3180
cagagctctg ctatcactga attacattta tctgaagaaa atagtacaac ttaatggatt 3240
agcttttggg tttaactgaa tatatgaaga aattgggtct gtctaaagag agggtatttc 3300
atatggcttt tagttcactt gtttgtattt catcttgatt tttttctttg gaaaataaag 3360
cattctattt ggttcagatt tctcagattt gaaaaaggct ctatctcaga tgtagtaaat 3420
tatttccttt cagtttgtga aagcaggatt tgactctgaa agaagctttg ccaattttac 3480
ttattcgtga tcaatcaagg aaaatctaat aaattttagg ccaaataaga atatagcata 3540
tttagtatgg ttatagtcaa cacagagatc acaacttaga agaaatataa agaaatggcc 3600
actccccatc ccccacagtc ctggagtaaa tcaaaatcaa tatatgattc ttttaaacat 3660
taagtttgaa ataggaatgg ttttctcaag aatagatttg gtgtgatacc ttgtgtttgc 3720
ttacattggc ccactatata tacatatata tttatgtaga tatacttcca tgaaagggct 3780
aatacgatgc atatactgaa gggcaaggac tttgaccatg tcaattttca gccgagaatg 3840
gtcagaaaga tcagtacaac cccatggatt aggctgaaac atatgaaatt gctgcatttg 3900
tagtttaaaa actgtcagca gtttcatatg gttccaccta atattattga agacaattat 3960
tttcttagct atcaataggc ttaatagttt tagttatttt agcttttgaa agtgttttaa 4020
aagatttcct ttatcggaca ggaccatctt tatgacctgc tttctgtttt tcaatatcat 4080
acattggtgt atgtcaaaga ataaattagt aaaattagta aaaaaaaaaa aaaaaaaaa  4139

<210> 12
<211> 653
<212> PRT
<213> homo sapiens

<400> 12
Met Pro Val Gly Gly Leu Leu Pro Leu Phe Ser Ser Pro Ala Gly Gly
 1               5                  10                  15      
Val Leu Gly Gly Gly Leu Gly Gly Gly Gly Gly Arg Lys Gly Ser Gly
            20                  25                  30          
Pro Ala Ala Leu Arg Leu Thr Glu Lys Phe Val Leu Leu Leu Val Phe
        35                  40                  45              
Ser Ala Phe Ile Thr Leu Cys Phe Gly Ala Ile Phe Phe Leu Pro Asp
    50                  55                  60                  
Ser Ser Lys Leu Leu Ser Gly Val Leu Phe His Ser Ser Pro Ala Leu
65                  70                  75                  80  
Gln Pro Ala Ala Asp His Lys Pro Gly Pro Gly Ala Arg Ala Glu Asp
                85                  90                  95      
Ala Ala Glu Gly Arg Ala Arg Arg Arg Glu Glu Gly Ala Pro Gly Asp
            100                 105                 110         
Pro Glu Ala Ala Leu Glu Asp Asn Leu Ala Arg Ile Arg Glu Asn His
        115                 120                 125             
Glu Arg Ala Leu Arg Glu Ala Lys Glu Thr Leu Gln Lys Leu Pro Glu
    130                 135                 140                 
Glu Ile Gln Arg Asp Ile Leu Leu Glu Lys Lys Lys Val Ala Gln Asp
145                 150                 155                 160 
Gln Leu Arg Asp Lys Ala Pro Phe Arg Gly Leu Pro Pro Val Asp Phe
                165                 170                 175     
Val Pro Pro Ile Gly Val Glu Ser Arg Glu Pro Ala Asp Ala Ala Ile
            180                 185                 190         
Arg Glu Lys Arg Ala Lys Ile Lys Glu Met Met Lys His Ala Trp Asn
        195                 200                 205             
Asn Tyr Lys Gly Tyr Ala Trp Gly Leu Asn Glu Leu Lys Pro Ile Ser
    210                 215                 220                 
Lys Gly Gly His Ser Ser Ser Leu Phe Gly Asn Ile Lys Gly Ala Thr
225                 230                 235                 240 
Ile Val Asp Ala Leu Asp Thr Leu Phe Ile Met Glu Met Lys His Glu
                245                 250                 255     
Phe Glu Glu Ala Lys Ser Trp Val Glu Glu Asn Leu Asp Phe Asn Val
            260                 265                 270         
Asn Ala Glu Ile Ser Val Phe Glu Val Asn Ile Arg Phe Val Gly Gly
        275                 280                 285             
Leu Leu Ser Ala Tyr Tyr Leu Ser Gly Glu Glu Ile Phe Arg Lys Lys
    290                 295                 300                 
Ala Val Glu Leu Gly Val Lys Leu Leu Pro Ala Phe His Thr Pro Ser
305                 310                 315                 320 
Gly Ile Pro Trp Ala Leu Leu Asn Met Lys Ser Gly Ile Gly Arg Asn
                325                 330                 335     
Trp Pro Trp Ala Ser Gly Gly Ser Ser Ile Leu Ala Glu Phe Gly Thr
            340                 345                 350         
Leu His Leu Glu Phe Met His Leu Ser His Leu Ser Gly Asn Pro Ile
        355                 360                 365             
Phe Ala Glu Lys Val Met Asn Ile Arg Thr Val Leu Asn Lys Leu Glu
    370                 375                 380                 
Lys Pro Gln Gly Leu Tyr Pro Asn Tyr Leu Asn Pro Ser Ser Gly Gln
385                 390                 395                 400 
Trp Gly Gln His His Val Ser Val Gly Gly Leu Gly Asp Ser Phe Tyr
                405                 410                 415     
Glu Tyr Leu Leu Lys Ala Trp Leu Met Ser Asp Lys Thr Asp Leu Glu
            420                 425                 430         
Ala Lys Lys Met Tyr Phe Asp Ala Val Gln Ala Ile Glu Thr His Leu
        435                 440                 445             
Ile Arg Lys Ser Ser Ser Gly Leu Thr Tyr Ile Ala Glu Trp Lys Gly
    450                 455                 460                 
Gly Leu Leu Glu His Lys Met Gly His Leu Thr Cys Phe Ala Gly Gly
465                 470                 475                 480 
Met Phe Ala Leu Gly Ala Asp Ala Ala Pro Glu Gly Met Ala Gln His
                485                 490                 495     
Tyr Leu Glu Leu Gly Ala Glu Ile Ala Arg Thr Cys His Glu Ser Tyr
            500                 505                 510         
Asn Arg Thr Phe Met Lys Leu Gly Pro Glu Ala Phe Arg Phe Asp Gly
        515                 520                 525             
Gly Val Glu Ala Ile Ala Thr Arg Gln Asn Glu Lys Tyr Tyr Ile Leu
    530                 535                 540                 
Arg Pro Glu Val Met Glu Thr Tyr Met Tyr Met Trp Arg Leu Thr His
545                 550                 555                 560 
Asp Pro Lys Tyr Arg Lys Trp Ala Trp Glu Ala Val Glu Ala Leu Glu
                565                 570                 575     
Asn His Cys Arg Val Asn Gly Gly Tyr Ser Gly Leu Arg Asp Val Tyr
            580                 585                 590         
Leu Leu His Glu Ser Tyr Asp Asp Val Gln Gln Ser Phe Phe Leu Ala
        595                 600                 605             
Glu Thr Leu Lys Tyr Leu Tyr Leu Ile Phe Ser Asp Asp Asp Leu Leu
    610                 615                 620                 
Pro Leu Glu His Trp Ile Phe Asn Ser Glu Ala His Leu Leu Pro Ile
625                 630                 635                 640 
Leu Pro Lys Asp Lys Lys Glu Val Glu Ile Arg Glu Glu
                645                 650             


<210> 13
<211> 5349
<212> DNA
<213> homo sapiens

<400> 13
ggggcgtggc cgtcgggcgg cgagccgcgc gctctcgccc cgggagggag tcacaggttc 60
gtacacgcga ggccgggcgc gcgcagccgg caggcgggtg aagtcttccc aggtgctgca 120
ggcggtgctg aggcacaggg tctgctgcag gagcagcggc ccgaacccgc tccagcggcc 180
cgccgccgcc agcggttccc gcgtcgcgtg tgtacccccg cgcactgaag gaggtccgcc 240
agccctcacc agcccccgcg gaccgtgcaa tggcccagcg taagaatgcc aagagcagcg 300
gcaacagcag cagcagcggc tccggcagcg gtagcacgag tgcgggcagc agcagccccg 360
gggcccggag agagacaaag catggaggac acaagaatgg gaggaaaggc ggactctcag 420
gaacttcatt cttcacgtgg tttatggtga ttgcattgct gggcgtctgg acatctgtag 480
ctgtcgtttg gtttgatctt gttgactatg aggaagttct aggaaaacta ggaatctatg 540
atgctgatgg tgatggagat tttgatgtgg atgatgccaa agttttatta ggacttaaag 600
agagatctac ttcagagcca gcagtcccgc cagaagaggc tgagccacac actgagcccg 660
aggagcaggt tcctgtggag gcagaacccc agaatatcga agatgaagca aaagaacaaa 720
ttcagtccct tctccatgaa atggtacacg cagaacatgt tgagggagaa gacttgcaac 780
aagaagatgg acccacagga gaaccacaac aagaggatga tgagtttctt atggcgactg 840
atgtagatga tagatttgag accctggaac ctgaagtatc tcatgaagaa accgagcata 900
gttaccacgt ggaagagaca gtttcacaag actgtaatca ggatatggaa gagatgatgt 960
ctgagcagga aaatccagat tccagtgaac cagtagtaga agatgaaaga ttgcaccatg 1020
atacagatga tgtaacatac caagtctatg aggaacaagc agtatatgaa cctctagaaa 1080
atgaagggat agaaatcaca gaagtaactg ctccccctga ggataatcct gtagaagatt 1140
cacaggtaat tgtagaagaa gtaagcattt ttcctgtgga agaacagcag gaagtaccac 1200
cagaaacaaa tagaaaaaca gatgatccag aacaaaaagc aaaagttaag aaaaagaagc 1260
ctaaactttt aaataaattt gataagacta ttaaagctga acttgatgct gcagaaaaac 1320
tccgtaaaag gggaaaaatt gaggaagcag tgaatgcatt taaagaacta gtacgcaaat 1380
accctcagag tccacgagca agatatggga aggcgcagtg tgaggatgat ttggctgaga 1440
agaggagaag taatgaggtg ctacgtggag ccatcgagac ctaccaagag gtggccagcc 1500
tacctgatgt ccctgcagac ctgctgaagc tgagtttgaa gcgtcgctca gacaggcaac 1560
aatttctagg tcatatgaga ggttccctgc ttaccctgca gagattagtt caactatttc 1620
ccaatgatac ttccttaaaa aatgaccttg gcgtgggata cctcttgata ggagataatg 1680
acaatgcaaa gaaagtttat gaagaggtgc tgagtgtgac acctaatgat ggctttgcta 1740
aagtccatta tggcttcatc ctgaaggcac agaacaaaat tgctgagagc atcccatatt 1800
taaaggaagg aatagaatcc ggagatcctg gcactgatga tgggagattt tatttccacc 1860
tgggggatgc catgcagagg gttgggaaca aagaggcata taagtggtat gagcttgggc 1920
acaagagagg acactttgca tctgtctggc aacgctcact ctacaatgtg aatggactga 1980
aagcacagcc ttggtggacc ccaaaagaaa cgggctacac agagttagta aagtctttag 2040
aaagaaactg gaagttaatc cgagatgaag gccttgcagt gatggataaa gccaaaggtc 2100
tcttcctgcc tgaggatgaa aacctgaggg aaaaagggga ctggagccag ttcacgctgt 2160
ggcagcaagg aagaagaaat gaaaatgcct gcaaaggagc tcctaaaacc tgtaccttac 2220
tagaaaagtt ccccgagaca acaggatgca gaagaggaca gatcaaatat tccatcatgc 2280
accccgggac tcacgtgtgg ccgcacacag ggcccacaaa ctgcaggctc cgaatgcacc 2340
tgggcttggt gattcccaag gaaggctgca agattcgatg tgccaacgag accaagacct 2400
gggaggaagg caaggtgctc atctttgatg actcctttga gcacgaggta tggcaggatg 2460
cctcatcttt ccggctgata ttcatcgtgg atgtgtggca tccggaactg acaccacagc 2520
agagacgcag ccttccagca atttagcatg aattcatgca agcttgggaa actctggaga 2580
gaggctgcct ttctggttcc atctccttgg gtgtgaggat agaatttcga acaccaagag 2640
tcaattccct tgacttgcag cccgagtaat tcaaagcctc ctcctagggt cagaagacac 2700
taaagggaat atttgcctcg ctgcaattca tttaggaaac accctgctgt gtgtcatctc 2760
atgacagcac tggtcttctg ccagtattta aggtgaacat ttgatagctt ctaccttacc 2820
agccaaagat attttttcca catagaatag gtctaattca atgtataatg agaacatatg 2880
tagaaactgt gaatggattg ctttagtttg taatttttct atgcagttat atttttctag 2940
tgtagctaga ctattttgtc atcatgtacc actacatttt tgtttatttt aatgacaagc 3000
tgtataaatg ctttacttct agctatttaa tggtagcatt actggggaac tcagacttcc 3060
ctcttttaat tcttcttagt aaaagatact catgaaaaaa gcagttttat tttcctaaca 3120
aaaaagaaag agctcattat gtcagtgtct atgaactgta cccatcccaa ctctcaaatc 3180
gtttggtttt ttttatcttg attgagatcc tcttctcact atgctagtgg tggagatatt 3240
gacaaaatcc tatttctttc aaagaggaac ttttcacacc gaaaaaagag catggaatta 3300
ttttatattg ttataaaaat cccagatgca aattttttta atgccaatta ttagagcttc 3360
tggggaaaaa gtatagttca cggaaataaa actatgttct ttcagggttg ggtggatagg 3420
tggctgctag ggtgtctggc tcctggcggc tttgccatcc atgaggcaag ggctgggaac 3480
acagtgtctt tgcctatggt agatccatgt gaatgtcagg aagccagctc ttcagtcttg 3540
gagatgattt ctgctacaat tctgtagaaa gattaaggat ggcagagtaa aaggttacca 3600
agaatgccag gatgtttttc ttgggcgtag gaggtccaga ttactttcct ttttgatgaa 3660
agagtttgga agactgtccc atctctctgg cttgagaaat ctctgccatt ttaaacatca 3720
ctgtgaaata gcaattatta tcatctgtat ttagttttaa cattacccac aacatagaaa 3780
taataggtaa aaatcgtctt gcctactcat tccaaagatg atcaagtcat taatctagca 3840
aagtattcat gtatcagatt ttgtatattt tgaatcaaag ctaactagga atgttagata 3900
taagaatgta atgatattca tgcactgaat tctaagccaa tatgaacaaa aatgctgcat 3960
gaatggcaca tataggtcac caaagttcat tcacaggtag aaaaaacttg tgctttcttt 4020
tccatctaaa aacaaaagga gactttcttt atctcattta aagaacagct ctttgaaatt 4080
gaaattgacc ctttttgctt gaccttaagg agattagctt ccagtagatg agtttgcaaa 4140
atacttttcc tgttcttttg ttttgctggt attgaaaaca tcccactaaa tcagatgaag 4200
aggcatggga ggaaaaatat ccaaattaat tactaaaatc gagaagagaa ggcaaactct 4260
tgaaaagtaa aaaggtgttt gtgaccttca gtatttattg aacagaggaa ataactgaca 4320
agggcaatac aattcaatgt tcatgtagta acattcatgt cacttgttga atttggttct 4380
catatgtata ttgcatacac ataaattcaa actataagtc gtcatttttg agccatcatc 4440
ttacattcat gtaatgaaat tatggaagag agtaaaaact agctcttaac ttagtaaata 4500
taatatggta tttaaaatca ggtcactaca gtaaggttct aagtattgcc aattgaaaag 4560
ctagaaatgg tattactgtt gcaaagtgtt gtcaataatt gactccaata gcattgtaaa 4620
tacttgtatc ccacaactat tttaaaccca agcaataaaa tggattttct aattcacttc 4680
aattctttat ttctcttacc tatctatgtc ttggtacata agaaaagtgt ttccatcact 4740
gcattggtag aattatttca gtgttattat ttttgtgatt tcgtatgtct acacaaaaat 4800
gaattagttt aatttatatt gtgatacagt tgtttgagaa atatttttaa ttctgtttca 4860
actttatttc tccaagtgta taatataaaa attacttctg ttattgttct ctaccaatag 4920
gggaaaaaat taaaacatta gatccattga gaaagagatg atgtaataaa taattaagat 4980
tagtaataat attatcaggg gtgattatga ccagttgaat aatctctttc ccttgaatta 5040
tttagctaac aaattaactc tcccaaatat ttaaaataat gtaaaatcat attttactgc 5100
ccattattaa ctaaaatatt tttgtttgac tttgagcacc aactggtaat actaataaat 5160
acccatgtca tgcagatggc tgggcgaata agagatgtct aaaaatatgc actggtcttg 5220
gaaaacatgg cacaagtaag gatatcatat atgatgtctg tttattttat gtctgatttc 5280
ttttgaatga gtagttgggg actccatttc taaggagact aggtaaataa aatgaccttt 5340
gacatttca                                                         5349



<210> 14
<211> 758
<212> PRT
<213> homo sapiens

<400> 14
Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser
 1               5                  10                  15      
Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala
            20                  25                  30          
Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly
        35                  40                  45              
Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu
    50                  55                  60                  
Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr
65                  70                  75                  80  
Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly
                85                  90                  95      
Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg
            100                 105                 110         
Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr
        115                 120                 125             
Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu
    130                 135                 140                 
Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His
145                 150                 155                 160 
Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr
                165                 170                 175     
Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val
            180                 185                 190         
Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr
        195                 200                 205             
Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln
    210                 215                 220                 
Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu
225                 230                 235                 240 
Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr
                245                 250                 255     
Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu
            260                 265                 270         
Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val
        275                 280                 285             
Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu
    290                 295                 300                 
Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro
305                 310                 315                 320 
Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys
                325                 330                 335     
Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg
            340                 345                 350         
Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val
        355                 360                 365             
Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys
    370                 375                 380                 
Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly
385                 390                 395                 400 
Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala
                405                 410                 415     
Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe
            420                 425                 430         
Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln
        435                 440                 445             
Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr
    450                 455                 460                 
Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val
465                 470                 475                 480 
Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe
                485                 490                 495     
Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys
            500                 505                 510         
Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr
        515                 520                 525             
Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr
    530                 535                 540                 
Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp
545                 550                 555                 560 
Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp
                565                 570                 575     
Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg
            580                 585                 590         
Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala
        595                 600                 605             
Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp
    610                 615                 620                 
Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala
625                 630                 635                 640 
Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu
                645                 650                 655     
Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro
            660                 665                 670         
Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg
        675                 680                 685             
Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys
    690                 695                 700                 
Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp
705                 710                 715                 720 
Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu
                725                 730                 735     
Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg
            740                 745                 750         
Arg Ser Leu Pro Ala Ile
        755             

