                              Sequence Listing

<110> GENENTECH, INC. et al.


<120> Fc Variants and Methods For Their Production

<130> P4587R1-WO


<150> US 61/439,750
<151> 2011-02-04

<160> 4

<210> 1
<211> 225
<212> PRT
<213> Homo sapiens

<400> 1
 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
   1               5                  10                  15

 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                  20                  25                  30

 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                  35                  40                  45

 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                  50                  55                  60

 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                  65                  70                  75

 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                  80                  85                  90

 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                  95                 100                 105

 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                 110                 115                 120

 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                 125                 130                 135

 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe
                 140                 145                 150

 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                 155                 160                 165

 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                 170                 175                 180

 Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                 185                 190                 195

 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
                 200                 205                 210

 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                 215                 220                 225

<210> 2
<211> 227
<212> PRT
<213> Homo sapiens

<400> 2
 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
   1               5                  10                  15

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                  20                  25                  30

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                  35                  40                  45

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                  50                  55                  60

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                  65                  70                  75

 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  80                  85                  90

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                  95                 100                 105

 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
                 110                 115                 120

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 125                 130                 135

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys
                 140                 145                 150

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 155                 160                 165

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 170                 175                 180

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 185                 190                 195

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 200                 205                 210

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 215                 220                 225

 Gly Lys
        

<210> 3
<211> 227
<212> PRT
<213> Homo sapiens

<400> 3
 Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu
   1               5                  10                  15

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                  20                  25                  30

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                  35                  40                  45

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                  50                  55                  60

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                  65                  70                  75

 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  80                  85                  90

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                  95                 100                 105

 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
                 110                 115                 120

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 125                 130                 135

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys
                 140                 145                 150

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 155                 160                 165

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 170                 175                 180

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 185                 190                 195

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 200                 205                 210

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 215                 220                 225

 Gly Lys
        

<210> 4
<211> 227
<212> PRT
<213> Homo sapiens

<400> 4
 Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu
   1               5                  10                  15

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                  20                  25                  30

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                  35                  40                  45

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                  50                  55                  60

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                  65                  70                  75

 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  80                  85                  90

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                  95                 100                 105

 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
                 110                 115                 120

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 125                 130                 135

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys
                 140                 145                 150

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 155                 160                 165

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 170                 175                 180

 Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser
                 185                 190                 195

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 200                 205                 210

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 215                 220                 225

 Gly Lys
        

