                         SEQUENCE LISTING

<110>  The Government of the United States of America
 
<120>  HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN 
       (FC)

<130>  4239-86663-02

<150>  US 61/439,678
<151>  2011-02-04

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01/QL sequence of Heavy Chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  1
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

cag ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg ctg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  2
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  3
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 LS heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  3
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg ctg cat gag gct ctg cac agc cac tac acg cag aag agc ctc       1392
Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  4
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  5
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 A heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  5
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac gcc cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  6
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  7
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 AAA heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  7
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc gcc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Ala Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gcg tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Ala Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac gcc cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  8
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Ala Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Ala Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  9
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 YTE heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  9
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc tat atc acc cgg gag cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  10
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  11
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DE heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  11
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  12
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  13
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DLE heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  13
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

ctc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  14
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  15
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DE-QL heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  15
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

cag ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg ctg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  16
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  17
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DE-LS heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  17
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg ctg cat gag gct ctg cac agc cac tac acg cag aag agc ctc       1392
Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  18
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  19
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DE-A heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  19
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac gcc cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  20
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  21
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DE-AAA heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  21
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc gcc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Ala Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gcg tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Ala Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac gcc cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  22
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Ala Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Ala Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  23
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DE-YTE heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  23
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc tat atc acc cgg gag cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

gcc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  24
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  25
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DLE-AAA heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  25
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc gcc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Ala Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

ctc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gcg tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Ala Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac gcc cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  26
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Ala Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Ala Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  27
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DLE-YTE heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  27
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc tat atc acc cgg gag cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

ctc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  28
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  29
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DLE-QL heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  29
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

cag ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

ctc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg ctg cat gag gct ctg cac aac cac tac acg cag aag agc ctc       1392
Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  30
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  31
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DLE-LS heavy chain


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  31
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

ctc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg ctg cat gag gct ctg cac agc cac tac acg cag aag agc ctc       1392
Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  32
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  33
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 DLE-A


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  33
atg gga tgg tca tgt atc atc ctt ttt cta gta gca act gca acc ggt         48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly           
1               5                   10                  15                

gta cat tcc cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys           
            20                  25                  30                    

cct ggc gag tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt        144
Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe           
        35                  40                  45                        

att gat tgt acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct        192
Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro           
    50                  55                  60                            

gag tgg atg gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca        240
Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala           
65                  70                  75                  80            

cgt cca ctt cag ggc aga gtg acc atg act cga gac gtt tat tcc gac        288
Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp           
                85                  90                  95                

aca gcc ttt ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc        336
Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val           
            100                 105                 110                   

tac ttt tgt act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa        384
Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu           
        115                 120                 125                       

cac tgg ggc cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag        432
His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys           
    130                 135                 140                           

ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg        480
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly           
145                 150                 155                 160           

ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg        528
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro           
                165                 170                 175               

gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc        576
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr           
            180                 185                 190                   

ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg        624
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val           
        195                 200                 205                       

gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac        672
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn           
    210                 215                 220                           

gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc        720
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro           
225                 230                 235                 240           

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa        768
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu           
                245                 250                 255               

ctc ctg ggg gga ccg gat gtc ttc ctc ttc ccc cca aaa ccc aag gac        816
Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
            260                 265                 270                   

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        864
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
        275                 280                 285                       

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc        912
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
    290                 295                 300                           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac        960
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
305                 310                 315                 320           

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1008
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
                325                 330                 335               

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1056
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
            340                 345                 350                   

ctc ccc gag gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa       1104
Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu           
        355                 360                 365                       

cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac       1152
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn           
    370                 375                 380                           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc       1200
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
385                 390                 395                 400           

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc       1248
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
                405                 410                 415               

acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag       1296
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
            420                 425                 430                   

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc       1344
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
        435                 440                 445                       

tcc gtg atg cat gag gct ctg cac gcc cac tac acg cag aag agc ctc       1392
Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu           
    450                 455                 460                           

tcc ctg tct ccg ggt aaa tga                                           1413
Ser Leu Ser Pro Gly Lys                                                   
465                 470                                                   


<210>  34
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  35
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 light chain


<220>
<221>  CDS
<222>  (1)..(312)

<400>  35
gaa att gtg ttg aca cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aca gcc atc atc tct tgt cgg acc agt cag tat ggt tcc tta gcc         96
Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala           
            20                  25                  30                    

tgg tat caa cag agg ccc ggc cag gcc ccc agg ctc gtc atc tat tcg        144
Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser           
        35                  40                  45                        

ggc tct act cgg gcc gct ggc atc cca gac agg ttc agc ggc agt cgg        192
Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg           
    50                  55                  60                            

tgg ggg cca gac tac aat ctc acc atc agc aac ctg gag tcg gga gat        240
Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp           
65                  70                  75                  80            

ttt ggt gtt tat tat tgc cag cag tat gaa ttt ttt ggc cag ggg acc        288
Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr           
                85                  90                  95                

aag gtc cag gtc gac att aag cga                                        312
Lys Val Gln Val Asp Ile Lys Arg                                           
            100                                                           


<210>  36
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  37
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC02 heavy chain


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  37
cag gtg cag ctg gtg cag tct ggg ggc cag atg aag aag cct ggc gag         48
Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu           
1               5                   10                  15                

tcg atg aga att tct tgt cag gct tcc gga tat gaa ttt att gat tgt         96
Ser Met Arg Ile Ser Cys Gln Ala Ser Gly Tyr Glu Phe Ile Asp Cys           
            20                  25                  30                    

aca cta aat tgg gtt cgc ctg gcc ccc gga aga agg cct gaa tgg atg        144
Thr Leu Asn Trp Val Arg Leu Ala Pro Gly Arg Arg Pro Glu Trp Met           
        35                  40                  45                        

gga tgg ctg aag cct cga ggg ggg gcc gtc aac tac gca cgt cca ctt        192
Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu           
    50                  55                  60                            

caa ggc aga gtg acc atg act cga gac gtg tat tcc gac aca gcc ttt        240
Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe           
65                  70                  75                  80            

ttg gag ctg cgc tcc ttg aca gca gac gac acg gcc gtc tac tat tgt        288
Leu Glu Leu Arg Ser Leu Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

act agg gga aaa aat tgt gat tac aat tgg gac ttc gaa cac tgg ggc        336
Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly           
            100                 105                 110                   

cgg ggt acc ccg gtc acc gtc tca tca gcg tcg acc aag ggc cca tcg        384
Arg Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser           
        115                 120                 125                       

gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg        432
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala           
    130                 135                 140                           

gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg        480
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val           
145                 150                 155                 160           

tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct        528
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala           
                165                 170                 175               

gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg        576
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val           
            180                 185                 190                   

ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac        624
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His           
        195                 200                 205                       

aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt        672
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys           
    210                 215                 220                           

gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg        720
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly           
225                 230                 235                 240           

gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg        768
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met           
                245                 250                 255               

atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac        816
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His           
            260                 265                 270                   

gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg        864
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val           
        275                 280                 285                       

cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac        912
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr           
    290                 295                 300                           

cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc        960
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly           
305                 310                 315                 320           

aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc       1008
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile           
                325                 330                 335               

gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg       1056
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val           
            340                 345                 350                   

tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc       1104
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser           
        355                 360                 365                       

ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag       1152
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu           
    370                 375                 380                           

tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc       1200
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro           
385                 390                 395                 400           

gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg       1248
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val           
                405                 410                 415               

gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg       1296
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met           
            420                 425                 430                   

cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct       1344
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser           
        435                 440                 445                       

ccg ggt aaa tga                                                       1356
Pro Gly Lys                                                               
    450                                                                   


<210>  38
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Gln Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Val Arg Leu Ala Pro Gly Arg Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  39
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC02 light chain


<220>
<221>  CDS
<222>  (1)..(312)

<400>  39
gaa att gtg ttg aca cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aca gcc atc atc tct tgt cgg acc agt cag tat ggt tcc tta gcc         96
Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala           
            20                  25                  30                    

tgg tat caa cag agg ccc ggc cag gcc ccc cgg ctc gtc atc tat tcg        144
Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser           
        35                  40                  45                        

ggc tct act cgg gcc gca ggc atc cca gac agg ttc agc ggc agt cgg        192
Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg           
    50                  55                  60                            

tgg ggg cca gac tac aat ctc acc atc agg aac ctg gag tcg gga gat        240
Trp Gly Pro Asp Tyr Asn Leu Thr Ile Arg Asn Leu Glu Ser Gly Asp           
65                  70                  75                  80            

ttt ggt ctt tat tat tgc cag cag tat gaa ttt ttt ggc cag ggg acc        288
Phe Gly Leu Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr           
                85                  90                  95                

aag gtc cag gtc gac att aag cga                                        312
Lys Val Gln Val Asp Ile Lys Arg                                           
            100                                                           


<210>  40
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Arg Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Leu Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  41
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC03 heavy chain


<220>
<221>  CDS
<222>  (1)..(1383)

<400>  41
cag gtg cag ctg gtg cag tct ggg gct gtg att aag acg cct ggg tcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Val Ile Lys Thr Pro Gly Ser           
1               5                   10                  15                

tca gtg aag atc tca tgt cgg gct tct gga tac aac ttt cgt gat tat         96
Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Asn Phe Arg Asp Tyr           
            20                  25                  30                    

tcg atc cat tgg gtc cgc ctc att cct gac aag gga ttt gag tgg att        144
Ser Ile His Trp Val Arg Leu Ile Pro Asp Lys Gly Phe Glu Trp Ile           
        35                  40                  45                        

gga tgg att aaa cct ctg tgg ggt gcc gtc agt tat gcc cgg caa ctt        192
Gly Trp Ile Lys Pro Leu Trp Gly Ala Val Ser Tyr Ala Arg Gln Leu           
    50                  55                  60                            

cag ggc cga gtc tct atg act cga caa tta tct caa gac cca gac gac        240
Gln Gly Arg Val Ser Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp           
65                  70                  75                  80            

ccg gac tgg ggc gtt gcc tac atg gag ttc agt gga ctg acg ccc gcc        288
Pro Asp Trp Gly Val Ala Tyr Met Glu Phe Ser Gly Leu Thr Pro Ala           
                85                  90                  95                

gac acg gcc gaa tat ttt tgt gtc cgg aga ggg tcc tgt gat tat tgc        336
Asp Thr Ala Glu Tyr Phe Cys Val Arg Arg Gly Ser Cys Asp Tyr Cys           
            100                 105                 110                   

gga gac ttt ccc tgg caa tac tgg ggt cag ggc acc gtc gtc gtc gtc        384
Gly Asp Phe Pro Trp Gln Tyr Trp Gly Gln Gly Thr Val Val Val Val           
        115                 120                 125                       

tcg tca gcg tcg acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc        432
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser           
    130                 135                 140                           

tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag        480
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys           
145                 150                 155                 160           

gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg        528
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu           
                165                 170                 175               

acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc        576
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu           
            180                 185                 190                   

tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc        624
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr           
        195                 200                 205                       

cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg        672
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val           
    210                 215                 220                           

gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca        720
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro           
225                 230                 235                 240           

ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc        768
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe           
                245                 250                 255               

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc        816
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
            260                 265                 270                   

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc        864
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
        275                 280                 285                       

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg        912
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
    290                 295                 300                           

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc        960
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
305                 310                 315                 320           

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc       1008
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
                325                 330                 335               

tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc       1056
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala           
            340                 345                 350                   

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg       1104
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
        355                 360                 365                       

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc       1152
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
    370                 375                 380                           

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg       1200
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
385                 390                 395                 400           

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc       1248
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
                405                 410                 415               

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag       1296
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
            420                 425                 430                   

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac       1344
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
        435                 440                 445                       

tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa tga                   1383
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                           
    450                 455                 460                           


<210>  42
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Val Ile Lys Thr Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Asn Phe Arg Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Leu Ile Pro Asp Lys Gly Phe Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Trp Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Val Ala Tyr Met Glu Phe Ser Gly Leu Thr Pro Ala 
                85                  90                  95      


Asp Thr Ala Glu Tyr Phe Cys Val Arg Arg Gly Ser Cys Asp Tyr Cys 
            100                 105                 110         


Gly Asp Phe Pro Trp Gln Tyr Trp Gly Gln Gly Thr Val Val Val Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  43
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC03 light chain


<220>
<221>  CDS
<222>  (1)..(309)

<400>  43
gaa att gtg ttg acg cag tct ccc ggc atc ctg tct ctg tct cca gga         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gag aca gcc acc ctc ttt tgt aag gcc agt cag ggt ggc aat gct atg         96
Glu Thr Ala Thr Leu Phe Cys Lys Ala Ser Gln Gly Gly Asn Ala Met           
            20                  25                  30                    

acg tgg tat cag aag aga cgt ggc cag gtt ccc aga ctc ctg atc tac        144
Thr Trp Tyr Gln Lys Arg Arg Gly Gln Val Pro Arg Leu Leu Ile Tyr           
        35                  40                  45                        

gat aca tct cgc agg gcc tct ggc gtt cct gac aga ttt gtt ggc agt        192
Asp Thr Ser Arg Arg Ala Ser Gly Val Pro Asp Arg Phe Val Gly Ser           
    50                  55                  60                            

ggg tct ggg aca gac ttc ttt ctc acg atc aac aaa ttg gac cgg gaa        240
Gly Ser Gly Thr Asp Phe Phe Leu Thr Ile Asn Lys Leu Asp Arg Glu           
65                  70                  75                  80            

gat ttc gca gtc tat tat tgt caa caa ttt gaa ttt ttt ggc ctg ggg        288
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Glu Phe Phe Gly Leu Gly           
                85                  90                  95                

agc gag ctg gaa gtc cat cga                                            309
Ser Glu Leu Glu Val His Arg                                               
            100                                                           


<210>  44
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Phe Cys Lys Ala Ser Gln Gly Gly Asn Ala Met 
            20                  25                  30          


Thr Trp Tyr Gln Lys Arg Arg Gly Gln Val Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Arg Arg Ala Ser Gly Val Pro Asp Arg Phe Val Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Phe Leu Thr Ile Asn Lys Leu Asp Arg Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Glu Phe Phe Gly Leu Gly 
                85                  90                  95      


Ser Glu Leu Glu Val His Arg 
            100             


<210>  45
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 heavy chain


<220>
<221>  CDS
<222>  (1)..(1356)

<400>  45
cag gtg cag ctg gtg cag tct gga ggt cag atg aag aag cct ggc gag         48
Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu           
1               5                   10                  15                

tcg atg aga att tct tgt cgg gct tct gga tat gaa ttt att gat tgt         96
Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys           
            20                  25                  30                    

acg cta aat tgg att cgt ctg gcc ccc gga aaa agg cct gag tgg atg        144
Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met           
        35                  40                  45                        

gga tgg ctg aag cct cgg ggg ggg gcc gtc aac tac gca cgt cca ctt        192
Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu           
    50                  55                  60                            

cag ggc aga gtg acc atg act cga gac gtt tat tcc gac aca gcc ttt        240
Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe           
65                  70                  75                  80            

ttg gag ctg cgc tcg ttg aca gta gac gac acg gcc gtc tac ttt tgt        288
Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

act agg gga aaa aac tgt gat tac aat tgg gac ttc gaa cac tgg ggc        336
Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly           
            100                 105                 110                   

cgg ggc acc ccg gtc atc gtc tca tca ccg tcg acc aag ggc cca tcg        384
Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys Gly Pro Ser           
        115                 120                 125                       

gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg        432
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala           
    130                 135                 140                           

gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg        480
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val           
145                 150                 155                 160           

tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct        528
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala           
                165                 170                 175               

gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg        576
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val           
            180                 185                 190                   

ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac        624
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His           
        195                 200                 205                       

aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt        672
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys           
    210                 215                 220                           

gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg        720
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly           
225                 230                 235                 240           

gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg        768
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met           
                245                 250                 255               

atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac        816
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His           
            260                 265                 270                   

gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg        864
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val           
        275                 280                 285                       

cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac        912
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr           
    290                 295                 300                           

cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc        960
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly           
305                 310                 315                 320           

aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc       1008
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile           
                325                 330                 335               

gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg       1056
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val           
            340                 345                 350                   

tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc       1104
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser           
        355                 360                 365                       

ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag       1152
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu           
    370                 375                 380                           

tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc       1200
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro           
385                 390                 395                 400           

gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg       1248
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val           
                405                 410                 415               

gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg       1296
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met           
            420                 425                 430                   

cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct       1344
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser           
        435                 440                 445                       

ccg ggt aaa tga                                                       1356
Pro Gly Lys                                                               
    450                                                                   


<210>  46
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  47
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 consensus sequenc

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Val Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Asp Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly Arg 
            100                 105                 110         


Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


