                         SEQUENCE LISTING

<110>  Amgen Inc.
       McCaffery, Ian
       Lu, Jian-Feng
      
 
<120>  Methods and Compositions Relating to Inhibition of IGF-1R

<130>  A-1610-WO-PCT

<140>  To be assigned
<141>  2012-02-02

<150>  US 61/438,918
<151>  2011-02-02

<160>  279   

<170>  PatentIn version 3.2

<210>  1
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  1
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

agt gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Ser Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg atc acc ttc ggc caa ggg aca cga ctg gag att aaa      336
Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys         
            100                 105                 110                 


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  2

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(327)

<400>  3
atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga gag ccg gcc       48
Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala         
1               5                   10                  15              

tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt aat gga tac       96
Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr         
            20                  25                  30                  

aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct cca cag ctc      144
Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu         
        35                  40                  45                      

ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct gac agg ttc      192
Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe         
    50                  55                  60                          

agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc agc aga gtg      240
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val         
65                  70                  75                  80          

gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct cta caa act      288
Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr         
                85                  90                  95              

ccg atc acc ttc ggc caa ggg aca cga ctg gag att aaa                  327
Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                     
            100                 105                                     


<210>  4
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  4

Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr 
            20                  25                  30          


Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu 
        35                  40                  45              


Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  5
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  5
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cca ctc act ttc ggc ggc ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  6

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  7
gaa att gtg atg acg cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct cac act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  8

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  9
gaa att gtg ctg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa acc cct ctc act ttc ggc cct ggg acc aaa gtg gat atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys         
            100                 105                 110                 


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  11
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  11
gat gtt gtg atg act cag tct cca ctc tcc ctg gcc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  12

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  13
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  14

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  15
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gaa gat gtt ggg gtt tat tac tgt atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa acc ccc ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  16

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  17
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg ttc acc ttc ggc caa ggg aca cga ctg gag att aaa      336
Leu Gln Thr Pro Phe Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys         
            100                 105                 110                 


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  18

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Phe Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  19
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  19
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct ctg gcg ttc ggc caa ggg acc aag gtg gaa atc aaa      336
Leu Gln Thr Pro Leu Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  20

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  21
gaa att gtg ctg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg aat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt gcc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct atc acc ttc ggc caa ggg aca cga ctg gag att aaa      336
Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys         
            100                 105                 110                 


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(333)

<400>  23
aat ttt atg ctg act cag ccc cac tct gtg tcg gag tct ccg ggg aag       48
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys         
1               5                   10                  15              

acg gta acc atc tcc tgc acc cgc agc agt ggc agc att gcc agc aac       96
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn         
            20                  25                  30                  

tat gtg cag tgg tac cag cag cgc ccg ggc agt tcc ccc acc act gtg      144
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val         
        35                  40                  45                      

atc tat gag gat aac caa aga ccc tct ggg gtc cct gat cgg ttc tct      192
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc tcc atc gac agc tcc tcc aac tct gcc tcc ctc acc atc tct gga      240
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly         
65                  70                  75                  80          

ctg aag act gag gac gag gct gac tac tac tgt cag tct tat gat agc      288
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser         
                85                  90                  95              

agc aat cag aga gtg ttc ggc gga ggg acc aag ctg acc gtc cta          333
Ser Asn Gln Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu             
            100                 105                 110                 


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  24

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Gln Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  25
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  25
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa acc ccg ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  26
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  26

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  27
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  27
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct ctt act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  28

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  29
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg caa aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct tat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Tyr Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt gcc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg atc acc ttc ggc caa ggg aca cga ctg gag att aaa      336
Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys         
            100                 105                 110                 


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  30

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Tyr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  31
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc agg gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa ggt      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly         
                85                  90                  95              

aca cac tgg cct ctg acg ttc ggc caa ggg acc aag gtg gag atc aaa      336
Thr His Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  32
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  32

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  33
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(333)

<400>  33
gaa att gtg atg acg cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct ctc act ttc ggc gga ggg acc aag gtg gag atc aa       335
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile             
            100                 105                 110                 


<210>  34
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  34

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110     


<210>  35
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  35
gac atc cag ttg acc cag tct cca tct tcc gtg tct gcg tct gtc gga       48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgt cgg gcg agt cag ggt att agc agg tgg       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp         
            20                  25                  30                  

tta gcc tgg tat caa cag aaa cca ggg aaa gcc cct aga ctc ctg atc      144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile         
        35                  40                  45                      

tat gct gcg tcc ggt tta caa agt ggg gtc cca tca agg ttc agc ggc      192
Tyr Ala Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc act ctc acc atc agc aac ctg cag cct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro         
65                  70                  75                  80          

gaa gat ttt gca act tac tat tgt caa cag gct agc agt ttt cca atc      288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Ile         
                85                  90                  95              

acc ttc ggc caa ggg aca cga ctg gag act aaa                          321
Thr Phe Gly Gln Gly Thr Arg Leu Glu Thr Lys                             
            100                 105                                     


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  36

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Thr Lys 
            100                 105         


<210>  37
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  37
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt gga gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg tac act ttt ggc cag ggg acc aag ctg gag atc aaa      336
Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  38

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  39
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

aac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cca ttc act ttc ggc cct ggg acc aaa gtg gat atc aaa      336
Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys         
            100                 105                 110                 


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  40

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  41
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  41
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

cat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
His Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca caa ctt ctg atc tat ttg ggt tct tat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Tyr Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa tct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser         
                85                  90                  95              

cta gaa gtt ccg ttc act ttt ggc cag ggg acc aag ctg gag atc aaa      336
Leu Glu Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  42

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


His Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Tyr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Glu Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  43
tct tct gag ctg act cag gac cct gct gtg tct gtg gcc ttg gga cag       48
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln         
1               5                   10                  15              

aca gtc agg atc aca tgc caa gga gac agc ctc aga att tat tat aca       96
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ile Tyr Tyr Thr         
            20                  25                  30                  

ggc tgg tac caa cag aag cca gga cag gcc cct gtg ctt gtc ctc ttt      144
Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Phe         
        35                  40                  45                      

ggt aag aac aat cgg ccc tca ggg atc cca gac cga ttc tct ggc tcc      192
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser         
    50                  55                  60                          

cac tca ggg aac aca gct tcc ttg acc atc act ggg gct caa gcg gaa      240
His Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu         
65                  70                  75                  80          

gat gag gct gac tat tac tgt aac tcc cgg gac atc act ggt gtc cat      288
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ile Thr Gly Val His         
                85                  90                  95              

cga ttc ggc gga ggg acc aag ctg acc gtc cta                          321
Arg Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                             
            100                 105                                     


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  44

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ile Tyr Tyr Thr 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Phe 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


His Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ile Thr Gly Val His 
                85                  90                  95      


Arg Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  45
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  45
gaa att gtg ctg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  46
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  46

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  47
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  47
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct aac act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  48

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  49
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cca atc act ttc ggc cct ggg acc aaa gtg gat atc aaa      336
Leu Gln Thr Pro Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys         
            100                 105                 110                 


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  50

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  51
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  51
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac acc tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca caa ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agc ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag cct gag gat gtt ggg gtc tat tac tgc atg caa gct      288
Ser Arg Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta gaa atg ccc ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Glu Met Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  52

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Glu Met Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  53
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  53
gac atc cag ttg acc cag tct cca tcc ttc ctg tct gca tct gta gga       48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgc cgg gcc agt cag ggc att agc agt tat       96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr         
            20                  25                  30                  

tta gcc tgg tat cag caa aaa cca ggg aaa gcc cct aag ctc ctg atc      144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile         
        35                  40                  45                      

tat gct gca tcc act ttg caa agt ggg gtc cca tca agg ttc agc ggc      192
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gaa ttc act ctc aca atc agc agc ctg cag cct      240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gaa gat ttt gca act tat tac tgt caa cag ctt aat agt tac ccc ctc      288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu         
                85                  90                  95              

act ttc ggc gga ggg acc aag gtg gag atc aaa                          321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                             
            100                 105                                     


<210>  54
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  54

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  55
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(315)

<400>  55
tcc tat gtg ctg act cag cca ccc tca gtg tcc gtg tcc cca gga cag       48
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln         
1               5                   10                  15              

aca gcc agc atc acc tgc tct gga gat aaa ttg ggg gat aaa tat gtt       96
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val         
            20                  25                  30                  

ggc tgg tat cag caa aag gca ggc caa gcc cct gtt ttg gtc atc tat      144
Gly Trp Tyr Gln Gln Lys Ala Gly Gln Ala Pro Val Leu Val Ile Tyr         
        35                  40                  45                      

caa gac aac aag cga ccc tca ggg atc cct gag cga ttc tct ggc tcc      192
Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser         
    50                  55                  60                          

aac tct ggg aac aca gcc agt ctg acc atc agc ggg acc cag gct atg      240
Asn Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Thr Gln Ala Met         
65                  70                  75                  80          

gat gag gct gac tat tac tgt cag gcg tgg gac agc ggc acg gtg ttc      288
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Thr Val Phe         
                85                  90                  95              

ggc gga ggg acc aag ctg acc gtc cta                                  315
Gly Gly Gly Thr Lys Leu Thr Val Leu                                     
            100                 105                                     


<210>  56
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  56

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Ala Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Thr Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  57
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  57
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa acc ccc ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  58
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  58

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  59
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg gaa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glu Ala         
                85                  90                  95              

cta caa act cca ttc act ttc ggc cct ggg acc aag gtg gaa atc aaa      336
Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  60
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  60

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glu Ala 
                85                  90                  95      


Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  61
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  61
gac atc cag ttg acc cag tct cca tcc tcc ctg tct gcg tct gtg gga       48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly         
1               5                   10                  15              

gac aga gtc acc atc act tgc cgg tca agt caa ggc att ggt tac ttc       96
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Gly Ile Gly Tyr Phe         
            20                  25                  30                  

tta aat tgg tat cag cag gaa cca ggg aaa gcc cca aag atc ctg atc      144
Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Ile Leu Ile         
        35                  40                  45                      

tct gct gca tcc act ttg caa agt ggg gtc cca tca agg ttc agt ggc      192
Ser Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc aca ctc tcc atc aac aat ctg caa ccc      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Asn Leu Gln Pro         
65                  70                  75                  80          

gca gat ttt gcg aca tac tac tgt caa cag agt cac agt ccc ccg tac      288
Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Pro Pro Tyr         
                85                  90                  95              

act ttc ggc cag ggg acc aag gtg gag atc aaa                          321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                             
            100                 105                                     


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  62

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Gly Ile Gly Tyr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Asn Leu Gln Pro 
65                  70                  75                  80  


Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  63
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  63
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  64
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  64

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  65
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  65
gaa att gtg ctg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atg tat ttg gtt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Met Tyr Leu Val Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gag agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa act      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr         
                85                  90                  95              

cta caa act cct ctc agt ttt ggc cag ggg acc aag ctg gag atc aaa      336
Leu Gln Thr Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 


<210>  66
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  66

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Met Tyr Leu Val Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr 
                85                  90                  95      


Leu Gln Thr Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  67
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  67
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  68
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  68

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  69
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(330)

<400>  69
aat ttt atg ctg act cag ccc cac tct gtg tcg gcg tct ccg ggg aag       48
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys         
1               5                   10                  15              

acg gtt acc atc tcc tgc acc cgc agc agt ggc gac att gac aac aac       96
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Asp Ile Asp Asn Asn         
            20                  25                  30                  

tat gtg cag tgg tac cag cag cgc ccg ggc aat tcc ccc acc aat gtg      144
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Asn Val         
        35                  40                  45                      

att tat gag gat aac cga aga ccc tct ggg gtc ccg gat cgc ttc tct      192
Ile Tyr Glu Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc tcc atc gac agc tcc tcc aac tct gcc tcc ctc acc atc tct gga      240
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly         
65                  70                  75                  80          

ctg cag cct gag gac gag gct gac tac tat tgt cag tct tat caa agc      288
Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Gln Ser         
                85                  90                  95              

gac aat tgg gtg ttc ggc gga ggg acc aag gtg acc gtc cta              330
Asp Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu                 
            100                 105                 110                 


<210>  70
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  70

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Asp Ile Asp Asn Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Asn Ser Pro Thr Asn Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Gln Ser 
                85                  90                  95      


Asp Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  71
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(330)

<400>  71
aat ttt atg ctg act cag ccc cac tct gtg tcg gag tct ccg ggg aag       48
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys         
1               5                   10                  15              

acg gta acc atc tcc tgc acc cgc agc agt ggc agc att gcc agc aac       96
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn         
            20                  25                  30                  

tat gtg cag tgg tac cag cag cgc ccg ggc agt tcc ccc acc act gtg      144
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val         
        35                  40                  45                      

atc tat gag gat aac caa aga ccc tct ggg gtc cct gat cga ttc tct      192
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc tcc atc gac agc tcc tcc aac tct gcc tcc ctc acc atc tct gga      240
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly         
65                  70                  75                  80          

ctg aag act gag gac gag gct gac tac tac tgt cag tct tat gat agc      288
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser         
                85                  90                  95              

agc aat gtg gtg ttc ggc gga ggg acc aag ctg acc gtc cta              330
Ser Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                 
            100                 105                 110                 


<210>  72
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  72

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  73
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  73
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct ggg       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aac cgg gac tct ggg gtc cca      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Asp Ser Gly Val Pro         
    50                  55                  60                          

gac aga ttc agc ggc agt ggg tca ggc act gat ttc aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc agg gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa ggt      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly         
                85                  90                  95              

aca cac tgg ccg tac act ttt ggc cag ggg acc agg ctg gag atc aaa      336
Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys         
            100                 105                 110                 


<210>  74
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  74

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  75
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  75
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag tcg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac ttt ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Phe Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  76
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  76

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Phe Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  77
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  77
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa acc ccc ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  78
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  78

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  79
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  79
gaa acg aca ctc acg cag tct cca gcc acc ctg tct ttg tct cca ggg       48
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly         
1               5                   10                  15              

caa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtc tac aac tac       96
Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Asn Tyr         
            20                  25                  30                  

tta gcc tgg tac caa cag aag cct ggc cag gct ccc agg ctc ctc atc      144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile         
        35                  40                  45                      

tat gat gca tcc aga agg gca act ggc atc cca gcc agg ttc agt ggc      192
Tyr Asp Ala Ser Arg Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly         
    50                  55                  60                          

agt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gag cct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro         
65                  70                  75                  80          

gaa gat ttt gca gtt tat tac tgt cag cag cgt aac aac tgg ccg ctc      288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Pro Leu         
                85                  90                  95              

act ttc ggt gga ggg acc aag gtg gag atc aaa                          321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                             
            100                 105                                     


<210>  80
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  80

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Arg Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  81
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  81
gac atc cag ttg acc cag tct cca tcc tcc ctg tct gct tct gtt gga       48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly         
1               5                   10                  15              

gac agc gtc acc atc tct tgc cgg gca agt cag agt cct ggc atc ttt       96
Asp Ser Val Thr Ile Ser Cys Arg Ala Ser Gln Ser Pro Gly Ile Phe         
            20                  25                  30                  

tta aat tgg tat cag cag ata cca ggg aaa gcc cct aaa ctc ctg atc      144
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile         
        35                  40                  45                      

tac gct aca tcc act ctg gaa agt ggg gtc ccc ccc agg ttc acc ggc      192
Tyr Ala Thr Ser Thr Leu Glu Ser Gly Val Pro Pro Arg Phe Thr Gly         
    50                  55                  60                          

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro         
65                  70                  75                  80          

gag gac ttt gca act tac tac tgt caa cag agt aac agt gtt ccg ctc      288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Val Pro Leu         
                85                  90                  95              

act ttc ggc ggc ggg acc aag gtg gag atc aaa                          321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                             
            100                 105                                     


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  82

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Ser Cys Arg Ala Ser Gln Ser Pro Gly Ile Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Glu Ser Gly Val Pro Pro Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  83
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  83
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca cta aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct cta acc ttc ggc caa ggg aca cga ctg gag att aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys         
            100                 105                 110                 


<210>  84
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  84

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  85
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  85
gaa att gtg atg acg cag tct cca gcc acc ctg tct gtg tct cca ggg       48
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly         
1               5                   10                  15              

gaa aga gcc acc ttc tcc tgt agg gcc agt cag agt gtt ggc agc aac       96
Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn         
            20                  25                  30                  

tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc atc      144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile         
        35                  40                  45                      

tat gat gca tcc aac agg gcc act ggc atc cca gcc agg ttc agt ggc      192
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly         
    50                  55                  60                          

agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag cct      240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro         
65                  70                  75                  80          

gaa gat ttt gca gtg tat tac tgt cag cag cgt agc aac tgg ccc ctc      288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu         
                85                  90                  95              

act ttc ggc gga ggg acc aag gtg gag atc aaa                          321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                             
            100                 105                                     


<210>  86
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  86

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  87
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  87
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccg ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  88
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  88

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  89
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  89
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tac ttg ggt tct act cgg gcc tcc ggc gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act cct tac act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  90
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  90

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  91
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  91
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

cta caa act ccc ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  92
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  92

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  93
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  93
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat act       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Thr         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cgg ctc ctg atc tat ttg ggt ttt aat cgg gcc tcc ggg gtc cct      192
Pro Arg Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgt atg caa ggt      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly         
                85                  90                  95              

cta caa act ccc ctc act ttc ggc gga ggg acc aag gtg gag atc aaa      336
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys         
            100                 105                 110                 


<210>  94
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  94

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  95
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  95
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser         
            20                  25                  30                  

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc agg gtg gag gct gag gat gtt ggg gtt tat tat tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

aca cac tgg ccg tac act ttt ggc cag ggg acc aag ctg gag atc aaa      336
Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 


<210>  96
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  96

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  97
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(330)

<400>  97
aat ttt atg ctg act cag ccc cac tct gtg tcg gag tct ccg ggg aag       48
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys         
1               5                   10                  15              

acg gta agc atc tcc tgc acc cgc aac agt ggc agc att gcc agc aac       96
Thr Val Ser Ile Ser Cys Thr Arg Asn Ser Gly Ser Ile Ala Ser Asn         
            20                  25                  30                  

ttt gtg cag tgg tac cag cag cgc ccg ggc agt gcc ccc acc att gta      144
Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Val         
        35                  40                  45                      

atc tat gag gat aac caa aga ccc tct gcg gtc cct act cgg ttc tct      192
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Ala Val Pro Thr Arg Phe Ser         
    50                  55                  60                          

ggc tcc atc gac agg tcc tcc aac tct gcc tcc ctc acc atc tct gga      240
Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly         
65                  70                  75                  80          

ctg acg act gag gac gag gct gac tac tac tgt cag tct tat gat agc      288
Leu Thr Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser         
                85                  90                  95              

gcc aat gtc att ttc ggc ggg ggg acc aag ctg acc gtc cta              330
Ala Asn Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                 
            100                 105                 110                 


<210>  98
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  98

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Ser Ile Ser Cys Thr Arg Asn Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Ala Val Pro Thr Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Thr Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ala Asn Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  99
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(324)

<400>  99
gaa acg aca ctc acg cag tct cca ggc acc ctg tct ttg tct cca ggg       48
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly         
1               5                   10                  15              

gag aga gcc acc ctc tcc tgc agg gcc agt cag act atc agc agc agc       96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Ser Ser         
            20                  25                  30                  

cac tta gcc tgg tac cag cag aaa cct ggc cag tct ccc agg ctc ctc      144
His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu         
        35                  40                  45                      

atc tat ggt gcg ggc tac agg gcc acc ggc att cca gac agg ttc agt      192
Ile Tyr Gly Ala Gly Tyr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc agt ggg tct ggc aca gac ttc act ctc acc atc agc aga ctg gag      240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu         
65                  70                  75                  80          

cct gaa gat ttt gca gtg tat tac tgt cag cac tat ggt agt tca ctc      288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Leu         
                85                  90                  95              

cgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa                      324
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                         
            100                 105                                     


<210>  100
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  100

Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Ser Ser 
            20                  25                  30          


His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Gly Tyr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Leu 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  101
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(330)

<400>  101
aat ttt atg ctg act cag ccc cac tct gtg tcg gag tct ccg ggg aag       48
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys         
1               5                   10                  15              

acg gta acc atc tcc tgc acc ggc agc ggt ggc aac att gcc agc aat       96
Thr Val Thr Ile Ser Cys Thr Gly Ser Gly Gly Asn Ile Ala Ser Asn         
            20                  25                  30                  

tat gtg cag tgg tac cag cag cgc ccg ggc agg gcc ccc acc act gtg      144
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Arg Ala Pro Thr Thr Val         
        35                  40                  45                      

atc tat gag gat aat cga aga ccc tct ggg gtc cct gat cgg ttc tct      192
Ile Tyr Glu Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc tcc atc gac agc tcc tcc aac tct gcc tcc ctc acc atc tct gga      240
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly         
65                  70                  75                  80          

ctg aag act gaa gac gag gct gac tac tac tgt cag tct tat gat ccc      288
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Pro         
                85                  90                  95              

tac aat cga gtg ttc ggc gga ggg acc aag ctg acc gtc cta              330
Tyr Asn Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                 
            100                 105                 110                 


<210>  102
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  102

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Ser Gly Gly Asn Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Arg Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Pro 
                85                  90                  95      


Tyr Asn Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  103
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region


<220>
<221>  CDS
<222>  (1)..(336)

<400>  103
gaa att gtg atg acg cag tct cca ctc tcc ctg ccc gtc acc cct gga       48
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly         
1               5                   10                  15              

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat act       96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Thr         
            20                  25                  30                  

aat gga tac gac tat ttg gat tgg tac ctg cag aag cca ggg cag tct      144
Asn Gly Tyr Asp Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser         
        35                  40                  45                      

cca cag ctt ctg atc tat ttg ggt tct act cgg gcc tcc ggg gtc cct      192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc agt ggc agt gga tcg ggc aca gat ttt aca ctg aaa atc      240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa gct      288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala         
                85                  90                  95              

ttt caa act ccg ctc act ttc ggc gga ggg acc aag atg gag atc aaa      336
Phe Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys         
            100                 105                 110                 


<210>  104
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  104

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Tyr Asp Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Phe Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys 
            100                 105                 110         


<210>  105
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  105
gag gtg cag ctg gtg gag acc ggc cca gga ctg gtg aag cct tcg ggg       48
Glu Val Gln Leu Val Glu Thr Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ttt aat tac tat gat agt agt gtc tgg ggc cag gga acc ctg      336
Ala Arg Phe Asn Tyr Tyr Asp Ser Ser Val Trp Gly Gln Gly Thr Leu         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  106
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  106

Glu Val Gln Leu Val Glu Thr Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asn Tyr Tyr Asp Ser Ser Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  107
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(348)

<400>  107
gag gtg cag ctg gtg gag acc ggc cca gga ctg gtg aag cct tcg ggg       48
Glu Val Gln Leu Val Glu Thr Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ggg gtt gag cag att gac tac tgg ggc cag gga acc ctg gtc      336
Ala Arg Gly Val Glu Gln Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val         
            100                 105                 110                 

acc gtc tca agc                                                      348
Thr Val Ser Ser                                                         
        115                                                             


<210>  108
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  108

Glu Val Gln Leu Val Glu Thr Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Glu Gln Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  109
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  109
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg act gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aaa aat tta gca gca ggg gcg gtt gcc tac tgg ggc cag ggc acc      336
Ala Lys Asn Leu Ala Ala Gly Ala Val Ala Tyr Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tca agc                                              354
Leu Val Thr Val Ser Ser                                                 
        115                                                             


<210>  110
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Leu Ala Ala Gly Ala Val Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  111
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  111
cag gtg cag cta cag cag tgg ggc gca gga ctg ttg aag cct tcg gag       48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggg tcc ttc agt ggt tac       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Phe Ser Gly Tyr         
            20                  25                  30                  

tac tgg agc tgg atc cgt cag ccc cca ggg aag ggg ctg gag tgg att      144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg gaa atc aat cat agt gga agt acc aac tac aac cgg tcc ctc aag      192
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Arg Ser Leu Lys         
    50                  55                  60                          

agt cga gtc acc ata tca gta gac acg tcc aag aac cag ttc tcc ctg      240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg agc tct gtg acc gcc gcg gac acg gct gtg tat tac tgt gcg      288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

aga ctt tca tat ggt tcg ggc gtt gac tac tgg ggc cag ggc acc ctg      336
Arg Leu Ser Tyr Gly Ser Gly Val Asp Tyr Trp Gly Gln Gly Thr Leu         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  112
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  112

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Arg Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Ser Tyr Gly Ser Gly Val Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  113
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(360)

<400>  113
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tca cag       48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg agg tat agc agc agc cgc aat gat gct ttt gat atc tgg ggc caa      336
Ala Arg Tyr Ser Ser Ser Arg Asn Asp Ala Phe Asp Ile Trp Gly Gln         
            100                 105                 110                 

ggg aca atg gtc acc gtc tca agc                                      360
Gly Thr Met Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  114
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  114

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Ser Ser Arg Asn Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  115
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  115
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat ggg cag ctg gat gct ttt gat atc tgg ggc caa ggg aca      336
Ala Arg Asp Gly Gln Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr         
            100                 105                 110                 

atg gtc acc gtc tca agc                                              354
Met Val Thr Val Ser Ser                                                 
        115                                                             


<210>  116
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  116

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gln Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  117
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  117
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ttt tgg gac tac tac ggt atg gac gtc tgg ggc caa ggg acc      336
Ala Arg Phe Trp Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr         
            100                 105                 110                 

acg gtc acc gtc tca agc                                              354
Thr Val Thr Val Ser Ser                                                 
        115                                                             


<210>  118
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  118

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Trp Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  119
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  119
cag gtg cag cta cag cag tgg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Gln Trp Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

gag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Glu Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gca gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat cgg tac tac ggt atg gac gtc tgg ggc caa ggg acc acg      336
Ala Arg Asp Arg Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  120
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  120

Gln Val Gln Leu Gln Gln Trp Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Glu Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  121
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  121
gag gtg cag ctg gtc gag tct ggc cca gga ctg gtg aag cct tcg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg tac atc tat tat agt ggg agc acc tac tac aac ccg tcc ctc      192
Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc atg tca gta gac acg tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gca gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga tgg agc tac ttg gat gct ttt gat atc tgg ggc caa ggg aca      336
Ala Arg Trp Ser Tyr Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr         
            100                 105                 110                 

atg gtc acc gtc tca agc                                              354
Met Val Thr Val Ser Ser                                                 
        115                                                             


<210>  122
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  123
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  123
gag gtg cag ctg gtg gag tct ggc cca gga ctg gtg aag cct tcg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat tac gat att ttc ggt atg gac gtc tgg ggc caa ggg acc      336
Ala Arg Asp Tyr Asp Ile Phe Gly Met Asp Val Trp Gly Gln Gly Thr         
            100                 105                 110                 

acg gtc acc gtc tca agc                                              354
Thr Val Thr Val Ser Ser                                                 
        115                                                             


<210>  124
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Ile Phe Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  125
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  125
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag tcc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Ser Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gcc aac aga gat gat gct ttt gat atc tgg ggc caa ggg aca      336
Ala Arg Ala Asn Arg Asp Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr         
            100                 105                 110                 

atg gtc acc gtc tca agc                                              354
Met Val Thr Val Ser Ser                                                 
        115                                                             


<210>  126
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  126

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Ser Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asn Arg Asp Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  127
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  127
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag ccg ggg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc      144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg      192
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agt ctg agc gcc gac gac acg gcc gta tat ttc tgt      288
Leu Gln Met Asn Ser Leu Ser Ala Asp Asp Thr Ala Val Tyr Phe Cys         
                85                  90                  95              

gcg tcg ggt ggc tgg tac ggg gac tac ttt gac tac tgg ggc cag gga      336
Ala Ser Gly Gly Trp Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tca agc                                          357
Thr Leu Val Thr Val Ser Ser                                             
        115                                                             


<210>  128
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Gly Trp Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  129
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(363)

<400>  129
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gaa ggg aac cga acg gtg act agt gct ttt gat atc tgg ggc      336
Ala Arg Glu Gly Asn Arg Thr Val Thr Ser Ala Phe Asp Ile Trp Gly         
            100                 105                 110                 

caa ggg aca atg gtc acc gtc tca agc                                  363
Gln Gly Thr Met Val Thr Val Ser Ser                                     
        115                 120                                         


<210>  130
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  130

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Arg Thr Val Thr Ser Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  131
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  131
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tac tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ggg ctg ggg gat agt agt ggt tat atc ctt tgg ggc caa ggg      336
Ala Arg Gly Leu Gly Asp Ser Ser Gly Tyr Ile Leu Trp Gly Gln Gly         
            100                 105                 110                 

aca atg gtc acc gtc tca agc                                          357
Thr Met Val Thr Val Ser Ser                                             
        115                                                             


<210>  132
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  132

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Asp Ser Ser Gly Tyr Ile Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  133
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  133
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tac tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ggg ctg ggg gat agt agt ggt tat atc ctt tgg ggc caa ggg      336
Ala Arg Gly Leu Gly Asp Ser Ser Gly Tyr Ile Leu Trp Gly Gln Gly         
            100                 105                 110                 

aca atg gtc acc gtc tca agc                                          357
Thr Met Val Thr Val Ser Ser                                             
        115                                                             


<210>  134
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  134

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Asp Ser Ser Gly Tyr Ile Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  135
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  135
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga tgg acc ggg cgt act gat gct ttt gat atc tgg ggc caa ggg      336
Ala Arg Trp Thr Gly Arg Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly         
            100                 105                 110                 

aca atg gtc acc gtc tca agc                                          357
Thr Met Val Thr Val Ser Ser                                             
        115                                                             


<210>  136
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  136

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Thr Gly Arg Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  137
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  137
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga caa ggg gcg tta gat gct ttt gat atc tgg ggc caa ggg acc      336
Ala Arg Gln Gly Ala Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr         
            100                 105                 110                 

acg gtc acc gtc tca agc                                              354
Thr Val Thr Val Ser Ser                                                 
        115                                                             


<210>  138
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  138

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Ala Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  139
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(366)

<400>  139
cag gtg cag ctg gtg gag tcc ggg gga ggc gtg gtc cga cct ggg ggg       48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttt agc agc tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc      144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tca act att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg      192
Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg cag atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aaa gag cgt ggc agt ggc tgg tcc tta gac aat atg gac gtc tgg      336
Ala Lys Glu Arg Gly Ser Gly Trp Ser Leu Asp Asn Met Asp Val Trp         
            100                 105                 110                 

ggc caa ggg acc acg gtc acc gtc tca agc                              366
Gly Gln Gly Thr Thr Val Thr Val Ser Ser                                 
        115                 120                                         


<210>  140
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  140

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Arg Gly Ser Gly Trp Ser Leu Asp Asn Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  141
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  141
cag gtg cag ctg gtg gag tct ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat agc agt ggg ttc tac ggt atg gac gtc tgg ggc caa ggg      336
Ala Arg Asp Ser Ser Gly Phe Tyr Gly Met Asp Val Trp Gly Gln Gly         
            100                 105                 110                 

acc acg gtc acc gtc tca agc                                          357
Thr Thr Val Thr Val Ser Ser                                             
        115                                                             


<210>  142
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  142

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gly Phe Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  143
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(360)

<400>  143
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg act gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga agc agc agc tgg tac tgg aat gct ttt gat atc tgg ggc caa      336
Ala Arg Ser Ser Ser Trp Tyr Trp Asn Ala Phe Asp Ile Trp Gly Gln         
            100                 105                 110                 

ggg aca atg gtc acc gtc tca agc                                      360
Gly Thr Met Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  144
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  144

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Ser Trp Tyr Trp Asn Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  145
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  145
cag gtg cag cta cag cag tgg ggc cca gca ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Gln Trp Gly Pro Ala Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc tct gtc tct ggt gtc tcc atc acc agt aat       96
Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Val Ser Ile Thr Ser Asn         
            20                  25                  30                  

atc tgg tgg agt tgg gtc cgc cag tcc cca ggg aag ggg ctg gag tgg      144
Ile Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa gtc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Val Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gct gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg ggg tac cgt agc ttc ggg gag tcc tac tgg ggc cag gga acc ctg      336
Ala Gly Tyr Arg Ser Phe Gly Glu Ser Tyr Trp Gly Gln Gly Thr Leu         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  146
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  146

Gln Val Gln Leu Gln Gln Trp Gly Pro Ala Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Val Ser Ile Thr Ser Asn 
            20                  25                  30          


Ile Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Val Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Tyr Arg Ser Phe Gly Glu Ser Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  147
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(366)

<400>  147
cag gtg cag cta cag cag tgg ggc gca ggg ctg ttg aag cct tcg gag       48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tct ctc acc tgc gtt gtc tat ggt ggg tcc ttc agc gat ttc       96
Thr Leu Ser Leu Thr Cys Val Val Tyr Gly Gly Ser Phe Ser Asp Phe         
            20                  25                  30                  

tac tgg agc tgg atc cgc cag ccc cca ggg aag ggg cca gag tgg att      144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Ile         
        35                  40                  45                      

ggg gaa gtc aat cct aga gga agc acc aac tac aac ccg tcc ctc aag      192
Gly Glu Val Asn Pro Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys         
    50                  55                  60                          

agt cga gcc acc ata tca cta gac acg tcc aag aac cag ttc tcc ctg      240
Ser Arg Ala Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg agt tct gtg acc gcc gcg gac acg gct gtg tat ttc tgt gcg      288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala         
                85                  90                  95              

aga ggt cct cgg ccc ggg aga gat ggc tac aat tac ttt gac aac tgg      336
Arg Gly Pro Arg Pro Gly Arg Asp Gly Tyr Asn Tyr Phe Asp Asn Trp         
            100                 105                 110                 

ggc cag ggc acc ctg gtc acc gtc tca agc                              366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                 
        115                 120                                         


<210>  148
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  148

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Tyr Gly Gly Ser Phe Ser Asp Phe 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Asn Pro Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ala Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Pro Arg Pro Gly Arg Asp Gly Tyr Asn Tyr Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  149
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  149
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ggt ata gca gca gct ggt caa ggt gac tac tgg ggc cag gga      336
Ala Arg Gly Ile Ala Ala Ala Gly Gln Gly Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tca agc                                          357
Thr Leu Val Thr Val Ser Ser                                             
        115                                                             


<210>  150
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  150

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Ala Ala Ala Gly Gln Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  151
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(363)

<400>  151
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

agt tac tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag      144
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu         
        35                  40                  45                      

tgg att ggg agt atc tat tat agt ggg agc acc tac tac aac ccg tcc      192
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser         
    50                  55                  60                          

ctc aag agt cga gtc acc ata tcc gta gac acg tcc aag aac cag ttc      240
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe         
65                  70                  75                  80          

tcc ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac      288
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr         
                85                  90                  95              

tgt gcg aga gat ggg gga tac tac tac tac ggt atg gac gtc tgg ggc      336
Cys Ala Arg Asp Gly Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly         
            100                 105                 110                 

caa ggg acc acg gtc acc gtc tca agc                                  363
Gln Gly Thr Thr Val Thr Val Ser Ser                                     
        115                 120                                         


<210>  152
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  152

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  153
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  153
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg agt agt ggt tat gat gct ttt gat atc tgg ggc caa ggg acc acg      336
Ala Ser Ser Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  154
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  154

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  155
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  155
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aat tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca cga tac agc tat gga acg gta gga att gac tac tgg ggc cag gga      336
Ala Arg Tyr Ser Tyr Gly Thr Val Gly Ile Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tca agc                                          357
Thr Leu Val Thr Val Ser Ser                                             
        115                                                             


<210>  156
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  156

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Tyr Gly Thr Val Gly Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  157
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)
<223>  heavy chain variable region

<400>  157
gag gtg cag ctg gtg cag tct ggg gga ggc gtg gtc cag cct ggg acg       48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Thr         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc agc ttc aga agt cat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser His         
            20                  25                  30                  

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg      144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gca gtt ata tca tat gat gga agt aat aaa tac tat gca gac tcc gtg      192
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gct gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg act ata ggg ccg ggg gga ttt gac tac tgg ggc cag ggc acc ctg      336
Ala Thr Ile Gly Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  158
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  158

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ile Gly Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  159
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  159
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc att aga aat tac       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Arg Asn Tyr         
            20                  25                  30                  

tac tgg agt tgg atc cgg cag ccc cca ggg aag gga ctg gag tgg att      144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg tat att tct gac agt ggg aat acc aac tac aat ccc tcc ctc aag      192
Gly Tyr Ile Ser Asp Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys         
    50                  55                  60                          

agt cga gtc acc ata tca gta gac acg tcc aag aac cag ttc tcc cta      240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg acc tct gtg acc gcc aca gac acg gct gcg tat ttc tgt gcg      288
Lys Leu Thr Ser Val Thr Ala Thr Asp Thr Ala Ala Tyr Phe Cys Ala         
                85                  90                  95              

aga cat cga agc agc tgg gca tgg tac ttc gat ctc tgg ggc cgt ggc      336
Arg His Arg Ser Ser Trp Ala Trp Tyr Phe Asp Leu Trp Gly Arg Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tca agc                                          357
Thr Leu Val Thr Val Ser Ser                                             
        115                                                             


<210>  160
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  160

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Arg Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Thr Asp Thr Ala Ala Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Ser Ser Trp Ala Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  161
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  161
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gtg ggc agt ggc tgg tac gtt gac tac tgg ggc cag gga acc      336
Ala Arg Val Gly Ser Gly Trp Tyr Val Asp Tyr Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tca agc                                              354
Leu Val Thr Val Ser Ser                                                 
        115                                                             


<210>  162
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  162

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Ser Gly Trp Tyr Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  163
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(360)

<400>  163
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gtt tct ggc tac tac tac tac ggt atg gac gtc tgg ggc caa      336
Ala Arg Val Ser Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln         
            100                 105                 110                 

ggg acc acg gtc acc gtc tca agc                                      360
Gly Thr Thr Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  164
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  164

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ser Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  165
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(369)

<400>  165
gag gtc cag ctg gta cag tct ggg gga ggc gtg gtc cag cct ggg agg       48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg      144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

gca gtt ata tca tat gat gga agt aat aaa tac tat gca gac tcc gtg      192
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gct gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aaa gcg tat agc agt ggc tgg tac gac tac tac ggt atg gac gtc      336
Ala Lys Ala Tyr Ser Ser Gly Trp Tyr Asp Tyr Tyr Gly Met Asp Val         
            100                 105                 110                 

tgg ggc caa ggg acc acg gtc acc gtc tca agc                          369
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                             
        115                 120                                         


<210>  166
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  166

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Tyr Ser Ser Gly Trp Tyr Asp Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  167
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  167
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gcc agc gtt gat gct ttt gat atc tgg ggc caa ggg aca atg      336
Ala Arg Ala Ser Val Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  168
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  168

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  169
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  169
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tac tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ggg ctg ggg gat agt agt ggt tat atc ctt tgg ggc caa ggg      336
Ala Arg Gly Leu Gly Asp Ser Ser Gly Tyr Ile Leu Trp Gly Gln Gly         
            100                 105                 110                 

aca atg gtc acc gtc tca agc                                          357
Thr Met Val Thr Val Ser Ser                                             
        115                                                             


<210>  170
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  170

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Asp Ser Ser Gly Tyr Ile Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  171
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(348)

<400>  171
cag gta cag ctg cag cag tca ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg act ccc gag gac acg gct gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca aga gat cac ggc ccc ttt gac tac tgg ggc cgg gga acc ctg gtc      336
Ala Arg Asp His Gly Pro Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val         
            100                 105                 110                 

acc gtc tca agc                                                      348
Thr Val Ser Ser                                                         
        115                                                             


<210>  172
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  172

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Gly Pro Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  173
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(360)

<400>  173
cag gtg cag ctg gtg caa tct ggg gga ggc gtg gtc cag cct ggg agg       48
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc gcc ttc agt agc tat       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr         
            20                  25                  30                  

ggc atg cac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtt      144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tca tac att agt agt agt agt agt acc ata tac tac gca gac tct gtg      192
Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat cga ttt ggg tcg ggg cac ttg ccc gac tac tgg ggc cag      336
Ala Arg Asp Arg Phe Gly Ser Gly His Leu Pro Asp Tyr Trp Gly Gln         
            100                 105                 110                 

gga acc ctg gtc acc gtc tca agc                                      360
Gly Thr Leu Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  174
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Phe Gly Ser Gly His Leu Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  175
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  175
cag gtg cag cta cag cag tgg ggc gca gga ctg ttg aag cct tcg gag       48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tat ggt ggg tcc ttc agt ggt tac       96
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr         
            20                  25                  30                  

tac tgg agc tgg atc cgc cag ccc cca ggg aag ggg ctg gag tgg att      144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg gaa atc aat cat agt gga agc acc aac tac aac ccg tcc ctc aag      192
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys         
    50                  55                  60                          

agt cga gtc acc ata tca gta gac acg tcc aag aac cag ttc tcc ctg      240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg agc tct gtg acc gcc gcg gac acg gct gtg tat tac tgt gcg      288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

aga gtt ggg tat agc agt ggc cgt gac gtt gac tac tgg ggc cag ggc      336
Arg Val Gly Tyr Ser Ser Gly Arg Asp Val Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tca agc                                          357
Thr Leu Val Thr Val Ser Ser                                             
        115                                                             


<210>  176
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  176

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Tyr Ser Ser Gly Arg Asp Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  177
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(360)

<400>  177
gag gtc cag ctg gtg gag tct ggc cca gga ctg gtg aag cct tcg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg atc cgg cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat agc agc agc tgg tac tac ggt atg gac gtc tgg ggc caa      336
Ala Arg Asp Ser Ser Ser Trp Tyr Tyr Gly Met Asp Val Trp Gly Gln         
            100                 105                 110                 

ggg acc acg gtc acc gtc tca agc                                      360
Gly Thr Thr Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  178
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Trp Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  179
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(348)

<400>  179
gag gtc cag ctg gtg gag tcc ggc cca gga ctg gtg aag cct tcg gag       48
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gta tat tat tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga tcg acg tgg tcc ctt gac tac tgg ggc cag ggc acc ctg gtc      336
Ala Arg Ser Thr Trp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val         
            100                 105                 110                 

acc gtc tca agc                                                      348
Thr Val Ser Ser                                                         
        115                                                             


<210>  180
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Trp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  181
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  181
gag gtc cag ctg gtg gag tct ggc cca gga ctg gtg aag cct tcg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gta tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ctc tcg ttt gcc gat cct ttt gat atc tgg ggc caa ggg aca      336
Ala Arg Leu Ser Phe Ala Asp Pro Phe Asp Ile Trp Gly Gln Gly Thr         
            100                 105                 110                 

atg gtc acc gtc tca agc                                              354
Met Val Thr Val Ser Ser                                                 
        115                                                             


<210>  182
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Phe Ala Asp Pro Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  183
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(366)

<400>  183
cag gtc cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg tcc       48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser         
1               5                   10                  15              

tcg gtg aag gtc tcc tgc aag gct tct gga ggc acc ttc agc agc tat       96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr         
            20                  25                  30                  

gct atc agc tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg      144
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met         
        35                  40                  45                      

gga agg atc atc ccc atc ctt ggt ata gca aac tac gca cag aag ttc      192
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe         
    50                  55                  60                          

cag ggc aga gtc acg att acc gcg gac aaa tcc acg agc aca gcc tac      240
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctg agc agc ctg aga tct gag gac acg gcc gtg tat tac tgt      288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca tat ggt tcg ggg agt tat tac gac tac tac tac atg gac gtc tgg      336
Ala Tyr Gly Ser Gly Ser Tyr Tyr Asp Tyr Tyr Tyr Met Asp Val Trp         
            100                 105                 110                 

ggc aaa ggg acc acg gtc acc gtc tca agc                              366
Gly Lys Gly Thr Thr Val Thr Val Ser Ser                                 
        115                 120                                         


<210>  184
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  184

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Gly Ser Gly Ser Tyr Tyr Asp Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  185
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  185
gag gtc cag ctg gtg cag tct ggg gga ggc ttg gtc cag cct ggg ggg       48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tcc ctg aga ctc tcc tgt tca gcc tcc gga ttc acc ttc agt agc tat       96
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Tyr         
            20                  25                  30                  

gct atg cac tgg gtc cgc cag gct cca ggg aag gga ctg gaa tat gtt      144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val         
        35                  40                  45                      

tca act att agt agt aat ggg gat agc aca tac tac gca gac tcc gtg      192
Ser Thr Ile Ser Ser Asn Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val         
    50                  55                  60                          

aag ggc aga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ctg caa atg aac agc ctg aga gct gag gac acg gct gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aaa gaa gaa gta tgg cta cag gct ttt gat atc tgg ggc caa ggg      336
Ala Lys Glu Glu Val Trp Leu Gln Ala Phe Asp Ile Trp Gly Gln Gly         
            100                 105                 110                 

aca atg gtc acc gtc tca agc                                          357
Thr Met Val Thr Val Ser Ser                                             
        115                                                             


<210>  186
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  186

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Asn Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Val Trp Leu Gln Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  187
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(345)

<400>  187
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag       48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agt agt aac       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn         
            20                  25                  30                  

tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg att      144
Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg gaa atc tat cat agt ggg agc acc aac tac aac ccc tcc ctc aag      192
Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys         
    50                  55                  60                          

agt cga gtc acc atc tca gta gac acg tcc aag aac cag ttc tcc ctg      240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tat tac tgt gcg      288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

aga gat aag gga tac atg gac gtc tgg ggc aaa ggg acc acg gtc acc      336
Arg Asp Lys Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr         
            100                 105                 110                 

gtc tca agc                                                          345
Val Ser Ser                                                             
        115                                                             


<210>  188
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  188

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  189
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(363)

<400>  189
cag gta cag ctg cag cag tca ggg gct gag gtg aag aag cct ggg tcc       48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser         
1               5                   10                  15              

tcg gtg aag gtc tcc tgc aag gct tct gga ggc acc ttc agc agc tat       96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr         
            20                  25                  30                  

gct atc agc tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg      144
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met         
        35                  40                  45                      

gga agg atc atc cct atc ctt ggt ata gca aac tac gca cag aag ttc      192
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe         
    50                  55                  60                          

cag ggc aga gtc acg att acc gcg gac aaa tcc acg agc aca gcc tac      240
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctg agc agc ctg aga tct gag gac acg gcc gtg tat tac tgt      288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat cat agg ttc gac tac gcc tgg tac ttc gat ctc tgg ggc      336
Ala Arg Asp His Arg Phe Asp Tyr Ala Trp Tyr Phe Asp Leu Trp Gly         
            100                 105                 110                 

cgt ggc acc ctg gtc acc gtc tca agc                                  363
Arg Gly Thr Leu Val Thr Val Ser Ser                                     
        115                 120                                         


<210>  190
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  190

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Arg Phe Asp Tyr Ala Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  191
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  191
cag gtg cag ctg cag gag tcg ggc cca gga ctg ctg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agc       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg gag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Glu Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtc tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat cta acg ggg agt ctt gac tac tgg ggc cag gga acc ctg      336
Ala Arg Asp Leu Thr Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  192
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  192

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Glu Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Thr Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  193
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(351)

<400>  193
cag gtg cag ctg cag gag tcc ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga ata cgc tat gat gct ttt gat atc tgg ggc caa ggg aca atg      336
Ala Arg Ile Arg Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met         
            100                 105                 110                 

gtc acc gtc tca agc                                                  351
Val Thr Val Ser Ser                                                     
        115                                                             


<210>  194
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  194

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Arg Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  195
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  195
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcc gtg acg gca gcc cat gat gct ttt gat atc tgg ggc caa ggg aca      336
Ala Val Thr Ala Ala His Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr         
            100                 105                 110                 

atg gtc acc gtc tca agc                                              354
Met Val Thr Val Ser Ser                                                 
        115                                                             


<210>  196
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  196

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Thr Ala Ala His Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  197
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  197
cag gtg cag cta cag cag tgg ggc cca gga ctg gtg aag cct tcg ggg       48
Gln Val Gln Leu Gln Gln Trp Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gac agc agt ggc caa ggg tac ttt gac tac tgg ggc cag ggc      336
Ala Arg Asp Ser Ser Gly Gln Gly Tyr Phe Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tca agc                                          357
Thr Leu Val Thr Val Ser Ser                                             
        115                                                             


<210>  198
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  198

Gln Val Gln Leu Gln Gln Trp Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gly Gln Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  199
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  199
gag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc       48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala         
1               5                   10                  15              

tca gtg aag gtc tcc tgc aag gct tct gga tac acc ttc act agc tat       96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr         
            20                  25                  30                  

gct atg cat tgg gtg cgc cag gcc ccc gga caa agg ctt gag tgg atg      144
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met         
        35                  40                  45                      

gga tgg atc aac gct ggc aat ggt aac aca aaa tat tca cag aag ttc      192
Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe         
    50                  55                  60                          

cag ggc aga gtc acc atg acc agg gac acg tcc acg agc aca gtc tac      240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr         
65                  70                  75                  80          

atg gag ctg agc agc ctg aga tct gag gac acg gcc gtg tat tac tgt      288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gct aga cac tcg tac tac tac ggt atg gac gtc tgg ggc caa ggc acc      336
Ala Arg His Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tca agc                                              354
Leu Val Thr Val Ser Ser                                                 
        115                                                             


<210>  200
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  200

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  201
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(360)

<400>  201
cag gtg cag cta cag cag tgg ggc gca gga ctg ttg aag cct tcg gag       48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tat ggt ggg tcc ttc agt ggt tac       96
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr         
            20                  25                  30                  

tac tgg agc tgg atc cgc cag ccc cca ggg aag ggg ctg gag tgg att      144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg gaa atc aat cat agt gga agc acc aac tac aac ccg tcc ctc aag      192
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys         
    50                  55                  60                          

agt cga gtc acc ata tcg gta gac acg tcc aag aac cag ttc tcc ctg      240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu         
65                  70                  75                  80          

aag ctg agc tct gtg acc gcc gcg gac acg gct gtg tat tac tgt gcg      288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

aga gtc ggg tat agc cac ggc gaa gaa gtc ctg gac gtc tgg ggc aaa      336
Arg Val Gly Tyr Ser His Gly Glu Glu Val Leu Asp Val Trp Gly Lys         
            100                 105                 110                 

ggg acc acg gtc acc gtc tca agc                                      360
Gly Thr Thr Val Thr Val Ser Ser                                         
        115                 120                                         


<210>  202
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  202

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Tyr Ser His Gly Glu Glu Val Leu Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  203
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(354)

<400>  203
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag       48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu         
1               5                   10                  15              

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc ggc aat tat       96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Gly Asn Tyr         
            20                  25                  30                  

gac tgg agt tgg atc cgg cag ccc cca ggg aag gga ctg gag tgg att      144
Asp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile         
        35                  40                  45                      

ggg act atc tac tct agt ggg agt acg tac tac agt ccg tcc ctc aag      192
Gly Thr Ile Tyr Ser Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu Lys         
    50                  55                  60                          

agt cga ctc acc ata tca gta gac aag tcc aag aac cgg ttc tcc ctg      240
Ser Arg Leu Thr Ile Ser Val Asp Lys Ser Lys Asn Arg Phe Ser Leu         
65                  70                  75                  80          

aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt gcg      288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala         
                85                  90                  95              

aga gca cga ggg tat agc agc ccc ttc gac ccc tgg ggc cag ggc acc      336
Arg Ala Arg Gly Tyr Ser Ser Pro Phe Asp Pro Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tca agc                                              354
Leu Val Thr Val Ser Ser                                                 
        115                                                             


<210>  204
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  204

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Gly Asn Tyr 
            20                  25                  30          


Asp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Ser Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Lys Ser Lys Asn Arg Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Arg Gly Tyr Ser Ser Pro Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  205
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(357)

<400>  205
cag gtc cag ctg gta cag tct ggg gct gag gtg aag aag cct ggg tcc       48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser         
1               5                   10                  15              

tcg gtg aag gtc tcc tgc aag gct tct gga ggc acc ttc agc agc tat       96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr         
            20                  25                  30                  

gct atc agc tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg      144
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met         
        35                  40                  45                      

gga ata atc aac cct agt ggt ggt agc aca agc tac gca cag aag ttc      192
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe         
    50                  55                  60                          

cag ggc aga gtc acc att acc agg gac aca tcc gcg agc aca gcc tac      240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctg agc agc ctg aga tct gaa gac acg gct gtg tat tac tgt      288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gat cgg tgg agg tac gat gct ttt gat atc tgg ggc caa ggg      336
Ala Arg Asp Arg Trp Arg Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly         
            100                 105                 110                 

aca atg gtc acc gtc tca agc                                          357
Thr Met Val Thr Val Ser Ser                                             
        115                                                             


<210>  206
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  206

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Trp Arg Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  207
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region


<220>
<221>  CDS
<222>  (1)..(348)

<400>  207
gag gtg cag ctg gtg gag tct ggc cca gga ctg gtg aag cct tcg ggg       48
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly         
1               5                   10                  15              

acc ctg tcc ctc acc tgc gct gtc tct ggt ggc tcc atc agc agt agt       96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser         
            20                  25                  30                  

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg      144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp         
        35                  40                  45                      

att ggg gaa atc tat cat agt ggg agc acc aac tac aac ccg tcc ctc      192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu         
    50                  55                  60                          

aag agt cga gtc acc ata tca gta gac aag tcc aag aac cag ttc tcc      240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser         
65                  70                  75                  80          

ctg aag ctg agc tct gtg acc gcc gcg gac acg gcc gtg tat tac tgt      288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gaa aaa tcg ggt atg gac gtc tgg ggc caa ggg acc acg gtc      336
Ala Arg Glu Lys Ser Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val         
            100                 105                 110                 

acc gtc tca agc                                                      348
Thr Val Ser Ser                                                         
        115                                                             


<210>  208
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Ser Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  209
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain constant region


<220>
<221>  CDS
<222>  (1)..(321)

<400>  209
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag       48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu         
1               5                   10                  15              

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc       96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe         
            20                  25                  30                  

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa      144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln         
        35                  40                  45                      

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc      192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser         
    50                  55                  60                          

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag      240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu         
65                  70                  75                  80          

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg      288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser         
                85                  90                  95              

ccc gtc aca aag agc ttc aac agg gga gag tgt                          321
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                             
            100                 105                                     


<210>  210
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain constant region

<400>  210

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  211
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region


<220>
<221>  CDS
<222>  (1)..(990)

<400>  211
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag       48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys         
1               5                   10                  15              

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac       96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr         
            20                  25                  30                  

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc      144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser         
        35                  40                  45                      

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc      192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser         
    50                  55                  60                          

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc      240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr         
65                  70                  75                  80          

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag      288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys         
                85                  90                  95              

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc      336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys         
            100                 105                 110                 

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca      384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro         
        115                 120                 125                     

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc      432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys         
    130                 135                 140                         

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg      480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp         
145                 150                 155                 160         

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag      528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu         
                165                 170                 175             

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg      576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu         
            180                 185                 190                 

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac      624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn         
        195                 200                 205                     

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg      672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly         
    210                 215                 220                         

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag      720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu         
225                 230                 235                 240         

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat      768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr         
                245                 250                 255             

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac      816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn         
            260                 265                 270                 

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc      864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe         
        275                 280                 285                     

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac      912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn         
    290                 295                 300                         

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg      960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr         
305                 310                 315                 320         

cag aag agc ctc tcc ctg tct ccg ggt aaa                              990
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                 
                325                 330                                 


<210>  212
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  212

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be any naturally occuring amino acid

<400>  213

Met Gln Ala Leu Gln Thr Pro Xaa Thr 
1               5                   


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is arginine or serine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is asparagine or serine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine or asparagine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is glycine, alanine, valine, leucine, isoleucine, proline, 
       phenylalinine, methionine, tryptophan or cysteine

<400>  214

Gln Gln Xaa Xaa Xaa Xaa Pro Leu Thr 
1               5                   


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Xaa is arginine, valine, or isoleucine or no amino acid

<400>  215

Gln Ser Tyr Asp Ser Ser Asn Xaa Xaa Val 
1               5                   10  


<210>  216
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3

<400>  216

Ser Arg Leu Asp Ala Phe Asp Ile 
1               5               


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  217

Ser Xaa Tyr Asp Tyr Tyr Gly Met Asp Val 
1               5                   10  


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  218

His Arg Xaa Asp Xaa Ala Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  219
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)

<400>  219

Asp Ser Ser Gly 
1               


<210>  220
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)

<400>  220

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  221
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is tyrosine or phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is alanine or asparagine

<400>  221

Arg Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Leu Xaa 
1               5                   10      


<210>  222
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is leucine or serine

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Xaa is independently any amino acid

<400>  222

Arg Ser Ser Gln Ser Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2

<400>  223

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  224
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2

<400>  224

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  225

Glu Asp Asn Xaa Arg Pro Ser 
1               5           


<210>  226
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1

<400>  226

Ser Ser Asn Trp Trp Ser 
1               5       


<210>  227
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  227

Xaa Tyr Tyr Trp Ser 
1               5   


<210>  228
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine or histidine

<400>  228

Ser Tyr Ala Met Xaa 
1               5   


<210>  229
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = glutamic acid or isoleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = tyrosine or asparagine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = histidine or tyrosine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = asparagine or tyrosine

<400>  229

Xaa Xaa Xaa Xaa Ser Gly Ser Thr Xaa Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  230
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = glycine or serine

<400>  230

Xaa Ile Ser Xaa Ser Gly Xaa Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  231
<211>  1162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIGF-1R:Fc


<220>
<221>  MISC_FEATURE
<222>  (1)..(1162)

<400>  231

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Asp Glu Val Asp Gly Cys Lys Pro 
    930                 935                 940                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
945                 950                 955                 960 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                965                 970                 975     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            980                 985                 990         


Phe Val Asp Asp Val Glu Val His  Thr Ala Gln Thr Gln  Pro Arg Glu 
        995                 1000                 1005             


Glu Gln  Phe Asn Ser Thr Phe  Arg Ser Val Ser Glu  Leu Pro Ile 
    1010                 1015                 1020             


Met His  Gln Asp Trp Leu Asn  Gly Lys Glu Phe Lys  Cys Arg Val 
    1025                 1030                 1035             


Asn Ser  Ala Ala Phe Pro Ala  Pro Ile Glu Lys Thr  Ile Ser Lys 
    1040                 1045                 1050             


Thr Lys  Gly Arg Pro Lys Ala  Pro Gln Val Tyr Thr  Ile Pro Pro 
    1055                 1060                 1065             


Pro Lys  Glu Gln Met Ala Lys  Asp Lys Val Ser Leu  Thr Cys Met 
    1070                 1075                 1080             


Ile Thr  Asp Phe Phe Pro Glu  Asp Ile Thr Val Glu  Trp Gln Trp 
    1085                 1090                 1095             


Asn Gly  Gln Pro Ala Glu Asn  Tyr Lys Asn Thr Gln  Pro Ile Met 
    1100                 1105                 1110             


Asp Thr  Asp Gly Ser Tyr Phe  Val Tyr Ser Lys Leu  Asn Val Gln 
    1115                 1120                 1125             


Lys Ser  Asn Trp Glu Ala Gly  Asn Thr Phe Thr Cys  Ser Val Leu 
    1130                 1135                 1140             


His Glu  Gly Leu His Asn His  His Thr Glu Lys Ser  Leu Ser His 
    1145                 1150                 1155             


Ser Pro  Gly Lys 
    1160         


<210>  232
<211>  1180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu INSR:fC


<220>
<221>  MISC_FEATURE
<222>  (1)..(1180)

<400>  232

Met Gly Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn His Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Thr 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Lys Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Val Asp Gly Cys 
945                 950                 955                 960 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                965                 970                 975     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            980                 985                 990         


Thr Cys Val Val Val Asp Ile Ser  Lys Asp Asp Pro Glu  Val Gln Phe 
        995                 1000                 1005             


Ser Trp  Phe Val Asp Asp Val  Glu Val His Thr Ala  Gln Thr Gln 
    1010                 1015                 1020             


Pro Arg  Glu Glu Gln Phe Asn  Ser Thr Phe Arg Ser  Val Ser Glu 
    1025                 1030                 1035             


Leu Pro  Ile Met His Gln Asp  Trp Leu Asn Gly Lys  Glu Phe Lys 
    1040                 1045                 1050             


Cys Arg  Val Asn Ser Ala Ala  Phe Pro Ala Pro Ile  Glu Lys Thr 
    1055                 1060                 1065             


Ile Ser  Lys Thr Lys Gly Arg  Pro Lys Ala Pro Gln  Val Tyr Thr 
    1070                 1075                 1080             


Ile Pro  Pro Pro Lys Glu Gln  Met Ala Lys Asp Lys  Val Ser Leu 
    1085                 1090                 1095             


Thr Cys  Met Ile Thr Asp Phe  Phe Pro Glu Asp Ile  Thr Val Glu 
    1100                 1105                 1110             


Trp Gln  Trp Asn Gly Gln Pro  Ala Glu Asn Tyr Lys  Asn Thr Gln 
    1115                 1120                 1125             


Pro Ile  Met Asp Thr Asp Gly  Ser Tyr Phe Val Tyr  Ser Lys Leu 
    1130                 1135                 1140             


Asn Val  Gln Lys Ser Asn Trp  Glu Ala Gly Asn Thr  Phe Thr Cys 
    1145                 1150                 1155             


Ser Val  Leu His Glu Gly Leu  His Asn His His Thr  Glu Lys Ser 
    1160                 1165                 1170             


Leu Ser  His Ser Pro Gly Lys  
    1175                 1180 


<210>  233
<211>  1062
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu IGF-1R:avidin

<400>  233

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Ala Ala Ala Ala Arg Lys Cys Ser Leu Thr Gly Lys Trp 
    930                 935                 940                 


Thr Asn Asp Leu Gly Ser Asn Met Thr Ile Gly Ala Val Asn Ser Lys 
945                 950                 955                 960 


Gly Glu Phe Thr Gly Thr Tyr Thr Thr Ala Val Thr Ala Thr Ser Asn 
                965                 970                 975     


Glu Ile Lys Glu Ser Pro Leu His Gly Thr Gln Asn Thr Ile Asn Lys 
            980                 985                 990         


Arg Thr Gln Pro Thr Phe Gly Phe  Thr Val Asn Trp Lys  Phe Ser Glu 
        995                 1000                 1005             


Ser Thr  Thr Val Phe Thr Gly  Gln Cys Phe Ile Asp  Arg Asn Gly 
    1010                 1015                 1020             


Lys Glu  Val Leu Lys Thr Met  Trp Leu Leu Arg Ser  Ser Val Asn 
    1025                 1030                 1035             


Asp Ile  Gly Asp Asp Trp Lys  Ala Thr Arg Val Gly  Ile Asn Ile 
    1040                 1045                 1050             


Phe Thr  Arg Leu Arg Thr Gln  Lys Glu 
    1055                 1060         


<210>  234
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human kappa light chain constant region

<400>  234

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  235
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  235

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  236
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is serine or threonine residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is asparagine, serine or histidine residue

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is tyrosine or phenylalanine residue

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is aspartate or asparagine residue

<400>  236

Arg Ser Ser Gln Ser Leu Leu His Xaa Xaa Gly Tyr Asn Xaa Leu Xaa 
1               5                   10                  15      


<210>  237
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is serine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is alanine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is serine or asparagine residue

<400>  237

Thr Arg Ser Ser Gly Xaa Ile Xaa Xaa Asn Tyr Val Gln 
1               5                   10              


<210>  238
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is glycine or serine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is isoleucine, valine or proline residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is serine, glycine or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is phenylalanine, tyrosine, asparagine or tryptophan residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is alanine or asparagine residue

<400>  238

Arg Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Leu Xaa 
1               5                   10      


<210>  239
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is glycine or valine residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is serine or phenylalanine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is asparagine, tyrosine or threonine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is alanine or aspartate residue

<400>  239

Leu Xaa Xaa Xaa Arg Xaa Ser 
1               5           


<210>  240
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alanine or threonine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is threonine or glycine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is glutamine or glutamate residue

<400>  240

Ala Xaa Ser Xaa Leu Xaa Ser 
1               5           


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is glutamate, glutamine or glycine residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aspartate or lysine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid residue

<400>  241

Xaa Xaa Asn Xaa Arg Pro Ser 
1               5           


<210>  242
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is glutamine or glutamate residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is alanine, glycine, serine or threonine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is leucine or threonine residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is glutamine, glutamate or histidine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is threonine, tryptophan, methionine or valine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is nonpolar side chain

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is threonine, serine or alanine residue

<400>  242

Met Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa 
1               5                   


<210>  243
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is arginine, serine, leucine or alanine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is asparagine, serine or histidine residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine or asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is nonpolar side chain

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is leucine, isoleucine, tyrosine or tryptophan residue

<400>  243

Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  244
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartate or glutamine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is serine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is glutamine, valine or tryptophan residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is arginine residue or no residue

<400>  244

Gln Ser Tyr Xaa Ser Xaa Asn Xaa Xaa Val 
1               5                   10  


<210>  245
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is serine residue or no residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is serine or asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is asparagine and isoleucine residue

<400>  245

Xaa Xaa Xaa Trp Trp Ser 
1               5       


<210>  246
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is glycine, asparagine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is tyrosine or phenylalanine residue

<400>  246

Xaa Xaa Tyr Trp Ser 
1               5   


<210>  247
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is alanine or glycine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is methionine or isoleucine residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine or histidine residue

<400>  247

Ser Tyr Xaa Xaa Xaa 
1               5   


<210>  248
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is glutamate, tyrosine or serine residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is isoleucine or valine residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is tyrosine, asparagine or serine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is histidine, tyrosine, aspartate,or proline residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine or arginine residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is serine or arginine residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is asparagine or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is lysine or glutamate residue

<400>  248

Xaa Xaa Xaa Xaa Xaa Gly Xaa Thr Xaa Tyr Asn Pro Ser Leu Xaa Ser 
1               5                   10                  15      


<210>  249
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is threonine, alanine, valine or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glycine, serine or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine, asparagine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is glycine or serine residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is glycine, serine or aspartate residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is serine, threonine or asparagine residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is threonine, lysine or isoleucine residue

<400>  249

Xaa Ile Ser Xaa Xaa Xaa Xaa Xaa Xaa Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  250
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is glutamate or no residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is tyrosine, glycine or serine or no residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is serine, asparagine, tryptophan or glutamate or no residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is serine, aspartate, tryptophan, alanine, arginine, 
       threonine, glutamine, leucine or glutamate or no residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine, glycine, asparagine, threonine, tryptophan, 
       alanine, valine or isoleucine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is arginine, glutamine, tyrosine, valine, alanine, glycine, 
       serine, phenylalanine or tryptophan residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is leucine, asparagine, aspartate, threonine, tryptophan, 
       tyrosine, valine, alanine, or histidine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is aspartate, serine, asparagine or glutamine residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is alanine or proline residue

<400>  250

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Asp Ile 
1               5                   10          


<210>  251
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is alanine or no residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is glutamate, tryosine or glycine or no residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is serine, asparagine, tryptophan, glutamate or no residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartate, glycine, serine, or valine residue, or no 
       residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is serine, glycine, or aspartate residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is glycine, phenylalanine, aspartate, serine, tryptophan, or 
       tyrosine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is a tyrosine, tryptophan, serine, or aspartate residue, or 
       no residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is aspartate, arginine, serine, glycine, tyrosine, or 
       tryptophan residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is tyrosine, isoleucine, leucine, phenylalanine, or lysine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is tyrosine, phenylalanine, aspartate, or glycine residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is glycine, tyrosine, or asparagine residue

<400>  251

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Asp Val 
1               5                   10                  


<210>  252
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is aspartate or valine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is glycine, tyrosine, arginine, or aspartate residue, or no 
       residue,

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is asparagine, leucine, glycine, isoleucine, serine, valine, 
       phenylalanine, or tyrosine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is leucine, serine, tryptophan, alanine, tyrosine, 
       isoleucine, glycine, or aspartate residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is glycine, alanine, tyrosine, serine, aspartate, or leucine 
       residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is valine, alanine, glycine, threonine, proline, histidine, 
       or glutamine residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is glutamate, glycine, serine, aspartate, glycine, valine, 
       tryptophan, histidine, or arginine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is glutamine, alanine, glycine, tyrosine, proline, leucine, 
       aspartate, or serine residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is nonpolar side chain residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is aspartate or alanine residue

<400>  252

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr 
1               5                   10      


<210>  253
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is glycine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is proline residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is arginine or aspartate residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is histidine or proline residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is arginine or glycine residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is arginine, serine, or phenylalanine residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is aspartate or serine residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is glycine, tryptophan, or tyrosine residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is tyrosine or alanine residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is asparagine or tryptophan residue

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is asparagine or leucine residue

<400>  253

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Phe Asp Xaa 
1               5                   10                  


<210>  254
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is phenylalanine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is asparagine or glycine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is tyrosine or a leucine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is a tyrosine or glycine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is a glycine, serine, or valine residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is tyrosine, phenylalanine, tryptophan, or glutamine residue,
       or no residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is tyrosine, glycine, or isoleucine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is tyrosine, leucine, or glycine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is methionine,  glycine, or phenylalanine residue, or no 
       residue

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is  aspartate or methionine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is a valine, aspartate, or tyrosine residue, or no residue

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is a valine residue, or no residue

<400>  254

Xaa Xaa Xaa Xaa Asp Ser Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  255
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  255
dykddddk                                                               8


<210>  256
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  256
agcaagcttc caccatgaag tctggctccg gaggagg                              37


<210>  257
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  257
atttgtcgac ttcgtccaga tggatgaagt tttcat                               36


<210>  258
<211>  3486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  258
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc     60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc    120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac    180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc    240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc    300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc    360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc    420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc    480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac    540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag    600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg    660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc    720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt    780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac    840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac    900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac    960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc   1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg   1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc   1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc   1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc   1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc   1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac   1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg   1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg   1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc   1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg   1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag   1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac   1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag   1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca   1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac   1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac   1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt   2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc   2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa   2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga   2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca   2280

gacacctaca acatcactga cccggaagag ctggagacag agtacccttt ctttgagagc   2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc   2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc   2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg   2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga   2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg   2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac   2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg   2760

ttcttctatg tccaggccaa aacaggatat gaaaacttca tccatctgga cgaagtcgac   2820

ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca   2880

aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac   2940

atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac   3000

acagctcaga cgcaaccccg ggaggagcag ttcaacagca ctttccgctc agtcagtgaa   3060

cttcccatca tgcaccagga ctggctcaat ggcaaggagt tcaaatgcag ggtaaacagt   3120

gcagctttcc ctgcccccat cgagaaaacc atctccaaaa ccaaaggcag accgaaggct   3180

ccacaggtgt acaccattcc acctcccaag gagcagatgg ccaaggataa agtcagtctg   3240

acctgcatga taacagactt cttccctgaa gacattactg tggagtggca gtggaatggg   3300

cagccagcgg agaactacaa gaacactcag cccatcatgg acacagatgg ctcttacttc   3360

gtctacagca agctcaatgt gcagaagagc aactgggagg caggaaatac tttcacctgc   3420

tctgtgttac atgagggcct gcacaaccac catactgaga agagcctctc ccactctcct   3480

ggtaaa                                                              3486


<210>  259
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  259
agcaagcttc caccatgggc accgggggcc gg                                   32


<210>  260
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  260
atttgtcgac ttttgcaata tttgacggga cgtctaa                              37


<210>  261
<211>  3540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  261
atgggcaccg ggggccggcg gggggcggcg gccgcgccgc tgctggtggc ggtggccgcg     60

ctgctactgg gcgccgcggg ccacctgtac cccggagagg tgtgtcccgg catggatatc    120

cggaacaacc tcactaggtt gcatgagctg gagaattgct ctgtcatcga aggacacttg    180

cagatactct tgatgttcaa aacgaggccc gaagatttcc gagacctcag tttccccaaa    240

ctcatcatga tcactgatta cttgctgctc ttccgggtct atgggctcga gagcctgaag    300

gacctgttcc ccaacctcac ggtcatccgg ggatcacgac tgttctttaa ctacgcgctg    360

gtcatcttcg agatggttca cctcaaggaa ctcggcctct acaacctgat gaacatcacc    420

cggggttctg tccgcatcga gaagaacaat gagctctgtt acttggccac tatcgactgg    480

tcccgtatcc tggattccgt ggaggataat cacatcgtgt tgaacaaaga tgacaacgag    540

gagtgtggag acatctgtcc gggtaccgcg aagggcaaga ccaactgccc cgccaccgtc    600

atcaacgggc agtttgtcga acgatgttgg actcatagtc actgccagaa agtttgcccg    660

accatctgta agtcacacgg ctgcaccgcc gaaggcctct gttgccacag cgagtgcctg    720

ggcaactgtt ctcagcccga cgaccccacc aagtgcgtgg cctgccgcaa cttctacctg    780

gacggcaggt gtgtggagac ctgcccgccc ccgtactacc acttccagga ctggcgctgt    840

gtgaacttca gcttctgcca ggacctgcac cacaaatgca agaactcgcg gaggcagggc    900

tgccaccagt acgtcattca caacaacaag tgcatccctg agtgtccctc cgggtacacg    960

atgaattcca gcaacttgct gtgcacccca tgcctgggtc cctgtcccaa ggtgtgccac   1020

ctcctagaag gcgagaagac catcgactcg gtgacgtctg cccaggagct ccgaggatgc   1080

accgtcatca acgggagtct gatcatcaac attcgaggag gcaacaatct ggcagctgag   1140

ctagaagcca acctcggcct cattgaagaa atttcagggt atctaaaaat ccgccgatcc   1200

tacgctctgg tgtcactttc cttcttccgg aagttacgtc tgattcgagg agagaccttg   1260

gaaattggga actactcctt ctatgccttg gacaaccaga acctaaggca gctctgggac   1320

tggagcaaac acaacctcac caccactcag gggaaactct tcttccacta taaccccaaa   1380

ctctgcttgt cagaaatcca caagatggaa gaagtttcag gaaccaaggg gcgccaggag   1440

agaaacgaca ttgccctgaa gaccaatggg gacaaggcat cctgtgaaaa tgagttactt   1500

aaattttctt acattcggac atcttttgac aagatcttgc tgagatggga gccgtactgg   1560

ccccccgact tccgagacct cttggggttc atgctgttct acaaagaggc cccttatcag   1620

aatgtgacgg agttcgatgg gcaggatgcg tgtggttcca acagttggac ggtggtagac   1680

attgacccac ccctgaggtc caacgacccc aaatcacaga accacccagg gtggctgatg   1740

cggggtctca agccctggac ccagtatgcc atctttgtga agaccctggt caccttttcg   1800

gatgaacgcc ggacctatgg ggccaagagt gacatcattt atgtccagac agatgccacc   1860

aacccctctg tgcccctgga tccaatctca gtgtctaact catcatccca gattattctg   1920

aagtggaaac caccctccga ccccaatggc aacatcaccc actacctggt tttctgggag   1980

aggcaggcgg aagacagtga gctgttcgag ctggattatt gcctcaaagg gctgaagctg   2040

ccctcgagga cctggtctcc accattcgag tctgaagatt ctcagaagca caaccagagt   2100

gagtatgagg attcggccgg cgaatgctgc tcctgtccaa agacagactc tcagatcctg   2160

aaggagctgg aggagtcctc gtttaggaag acgtttgagg attacctgca caacgtggtt   2220

ttcgtcccca gaaaaacctc ttcaggcact ggtgccgagg accctaggcc atctcggaaa   2280

cgcaggtccc ttggcgatgt tgggaatgtg acggtggccg tgcccacggt ggcagctttc   2340

cccaacactt cctcgaccag cgtgcccacg agtccggagg agcacaggcc ttttgagaag   2400

gtggtgaaca aggagtcgct ggtcatctcc ggcttgcgac acttcacggg ctatcgcatc   2460

gagctgcagg cttgcaacca ggacacccct gaggaacggt gcagtgtggc agcctacgtc   2520

agtgcgagga ccatgcctga agccaaggct gatgacattg ttggccctgt gacgcatgaa   2580

atctttgaga acaacgtcgt ccacttgatg tggcaggagc cgaaggagcc caatggtctg   2640

atcgtgctgt atgaagtgag ttatcggcga tatggtgatg aggagctgca tctctgcgtc   2700

tcccgcaagc acttcgctct ggaacggggc tgcaggctgc gtgggctgtc accggggaac   2760

tacagcgtgc gaatccgggc cacctccctt gcgggcaacg gctcttggac ggaacccacc   2820

tatttctacg tgacagacta tttagacgtc ccgtcaaata ttgcaaaagt cgacggttgt   2880

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc   2940

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc   3000

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct   3060

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc   3120

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtaaa cagtgcagct   3180

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag   3240

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc   3300

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca   3360

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac   3420

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg   3480

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa   3540


<210>  262
<211>  1409
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  262
tctagaccac catggacatc aggctcagct tagttttcct tgtccttttc ataaaaggtg     60

tccagtgtga ggtagaactg gtggagtctg ggggcggctt agtacaacct ggaaggtcca    120

tgacactctc ctgtgcagcc tcgggattca ctttcagaac ctatggcatg gcctgggtcc    180

gccaggcccc aacgaagggt ctggagtggg tctcatcaat tactgctagt ggtggtacca    240

cctactatcg agactccgtg aagggccgct tcactatttt tagggataat gcaaaaagta    300

ccctatacct gcagatggac agtccgaggt ctgaggacac ggccacttat ttctgtacat    360

caatttcgga atactggggc cacggagtca tggtcaccgt ctctagtgcc tccaccaagg    420

gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc acagcggccc    480

tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg    540

ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga ctctactccc    600

tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac atctgcaacg    660

tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa tcttgtgaca    720

aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg tcagtcttcc    780

tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag gtcacatgcg    840

tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac gtggacggcg    900

tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc acgtaccgtg    960

tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag tacaagtgca   1020

aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa gccaaagggc   1080

agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg accaagaacc   1140

aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc gtggagtggg   1200

agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg gactccgacg   1260

gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag caggggaacg   1320

tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag aagagcctct   1380

ccctgtctcc gggtaaatga taagtcgac                                     1409


<210>  263
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein

<400>  263

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  264
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein

<400>  264

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  265
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  265
gcaagcttgg gagaaatctg cgggccag                                        28


<210>  266
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  266
attgcggccg cttcatatcc tgttttggcc tg                                   32


<210>  267
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  267
attgcggccg ccccacattc ctttgggggc                                      30


<210>  268
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  268
agcaagcttg gacctgtgtc cagggacc                                        28


<210>  269
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  269
attgcggccg cgcaaggacc ttcacaaggg                                      30


<210>  270
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  270
agcaagcttg ccgaaggtct gtgaggaag                                       29


<210>  271
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  271
attgcggccg cactttcaca ggaggctctc                                      30


<210>  272
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  272
agcaagcttg gacgtcctgc atttcacctc                                      30


<210>  273
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  273
attgcggccg cggtgcgaat gtacaagatc tc                                   32


<210>  274
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  274
agcaagcttg aatgcttcag ttccttccat tc                                   32


<210>  275
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  275
attgcggccg cagtccttgc aaagacgaag ttg                                  33


<210>  276
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  276
agcaagcttg atgcccgcag aaggagcag                                       29


<210>  277
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  277
attgcggccg ctttaatggc cactctggtt tc                                   32


<210>  278
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  278
agcaagcttg ggagaaatct gcgggccag                                       29


<210>  279
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid

<400>  279
agcaagcttg ggagaaatct gcgggccag                                       29


